CN113143890A - Electricity-synergetic hydrolysis oxygen supply wound repair patch and preparation method thereof - Google Patents
Electricity-synergetic hydrolysis oxygen supply wound repair patch and preparation method thereof Download PDFInfo
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- CN113143890A CN113143890A CN202110376447.9A CN202110376447A CN113143890A CN 113143890 A CN113143890 A CN 113143890A CN 202110376447 A CN202110376447 A CN 202110376447A CN 113143890 A CN113143890 A CN 113143890A
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- substrate
- wound repair
- repair patch
- electrically
- oxygen
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- 239000001301 oxygen Substances 0.000 title claims abstract description 71
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 71
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims abstract description 70
- 230000037314 wound repair Effects 0.000 title claims abstract description 47
- 230000007062 hydrolysis Effects 0.000 title claims abstract description 33
- 238000006460 hydrolysis reaction Methods 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title abstract description 9
- 239000000758 substrate Substances 0.000 claims abstract description 73
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- 239000000463 material Substances 0.000 claims abstract description 20
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- 238000010438 heat treatment Methods 0.000 claims description 12
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 6
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- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 3
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- OOIBFPKQHULHSQ-UHFFFAOYSA-N (3-hydroxy-1-adamantyl) 2-methylprop-2-enoate Chemical compound C1C(C2)CC3CC2(O)CC1(OC(=O)C(=C)C)C3 OOIBFPKQHULHSQ-UHFFFAOYSA-N 0.000 claims description 2
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- DQJJMWZRDSGUJP-UHFFFAOYSA-N ethenoxyethene;furan-2,5-dione Chemical compound C=COC=C.O=C1OC(=O)C=C1 DQJJMWZRDSGUJP-UHFFFAOYSA-N 0.000 description 1
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Images
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
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- C25B1/00—Electrolytic production of inorganic compounds or non-metals
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/30—Hydrogen technology
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- Health & Medical Sciences (AREA)
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Abstract
The invention discloses an electric synergetic hydrolysis oxygen supply wound repair patch and a preparation method thereof, wherein the electric synergetic hydrolysis oxygen supply wound repair patch comprises a substrate, a positive electrode, a negative electrode and a microneedle, wherein the substrate is provided with a first surface; the anode and the cathode are both arranged on the substrate and are respectively used for being electrically connected with a power supply; the microneedles are located on the first surface; wherein the material of the substrate is a hydrogel. According to the technical scheme, after the power supply is applied to the positive electrode and the negative electrode, the electrodes are hydrolyzed in the substrate material to generate oxygen, the oxygen is released to the wound surface, and the wound repair is promoted, so that the oxygen is provided for the wound surface, and the wound healing is promoted.
Description
Technical Field
The invention relates to the technical field of wound repair, in particular to an electrically-synergistic hydrolysis oxygen supply wound repair patch and a preparation method thereof.
Background
Wound surfaces frequently occur in daily life, surgical operations and the like, and wound surface repair is a problem of great concern in the medical and health field all over the world. The wound surface is not healed due to various reasons, such as circulation factors, nutritional factors, neurohumoral factors and the like, and the wound surface is anoxic, so that the wound surface becomes a good culture medium for bacteria if the wound surface is anoxic for a long time, and the wound surface is infected.
Oxygen is an essential substance for life, can promote cell proliferation, tissue generation and tissue remodeling, and sufficient oxygen is one of the prerequisites for successful healing of the wound surface.
Disclosure of Invention
The invention mainly aims to provide an electrically-synergistic hydrolysis oxygen supply wound repair patch and a preparation method thereof, and aims to provide oxygen for a wound and promote the wound to heal.
In order to achieve the purpose, the electrically-synergetic hydrolysis oxygen supply wound repair patch provided by the invention comprises a substrate, a positive electrode, a negative electrode and a microneedle, wherein the substrate is provided with a first surface; the anode and the cathode are both arranged on the substrate and are respectively used for being electrically connected with a power supply; the microneedles are located on the first surface; wherein the material of the substrate is hydrogel.
In one embodiment, the material of the microneedles is a hydrogel, a saccharide, or a polymer.
In one embodiment, the hydrogel of the substrate is a polyvinyl alcohol hydrogel; and/or the hydrogel of the microneedle is one or more of methacrylated gelatin, methacrylated hyaluronic acid and methacrylated chitosan; alternatively, the saccharide of the microneedle comprises one or more of maltose, mannitol, trehalose, sucrose, xylitol, galactose and polysaccharide; alternatively, the polymer of the microneedle comprises one or more of Polymethylmethacrylate (PMMA), polylactic acid (PLA), polylactic-co-glycolic acid (PLGA), polyglycolic acid (PGA), polycarbonate, cyclic olefin copolymer, polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), Polystyrene (PS), polymethylvinylether-maleic anhydride.
In one embodiment, the microneedles are hard hydrogels and the substrate is a soft hydrogel.
In an embodiment, the positive electrode and/or the negative electrode are located within the substrate.
In one embodiment, the positive electrode and the negative electrode are arranged at intervals in the extending direction of the substrate; alternatively, the positive electrode and the negative electrode are disposed at an interval in a thickness direction of the substrate.
In an embodiment, the electrically-collaborative hydrolysis oxygen supply wound repair patch further includes a power supply, and the power supply is electrically connected with the positive electrode and the negative electrode respectively.
In one embodiment, the microneedles are less than 1 millimeter in height.
In an embodiment, an adhesive layer is further disposed on the first surface, and the adhesive layer is used for attaching the substrate to the skin.
The invention also provides a preparation method of the electrically-synergetic hydrolysis oxygen-supply wound repair patch, which is used for preparing the electrically-synergetic hydrolysis oxygen-supply wound repair patch and comprises the following steps:
filling a microneedle raw material solution in a mold cavity of the microneedle template;
removing bubbles at room temperature under negative pressure or centrifuging to remove bubbles, wherein the centrifuging speed is 2000rpm to 4000 rpm;
heating and concentrating at 30-45 deg.C for 5-6 hr;
curing by adopting ultraviolet light to obtain the micro-needle attached to the micro-needle template;
adding a base raw material solution, a positive electrode and a negative electrode on the microneedles;
and heating and drying for more than 12 hours, and demolding to obtain the electrically-synergistic hydrolysis oxygen supply wound repair patch.
According to the technical scheme, the positive electrode and the negative electrode are arranged on the substrate, the substrate is made of the hydrogel material and is electrically connected with the positive electrode and the negative electrode through the power supply, and the positive electrode and the negative electrode carry out electrolytic water reaction on water of the substrate to generate oxygen, so that oxygen is actively provided for a wound surface, and healing of the wound surface is accelerated. Meanwhile, the microneedle is arranged on the substrate, when the electrically-synergetic hydrolysis oxygen supply wound repair patch is pasted on the skin of a user, the microneedle can pierce the skin to reach the dermis layer, so that generated oxygen can enter the skin, the permeability and the absorbability of the skin to the oxygen are further enhanced, the repair and healing of the wound are further promoted, and the microneedle does not contact with the capillary vessels and nerve endings in the skin, so that the user acceptance is high.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.
FIG. 1 is a schematic structural diagram of an embodiment of an electrically-assisted hydrolysis oxygen-supplying wound repair patch of the present invention;
fig. 2 is a schematic diagram of the preparation process of the electrically-synergistic hydrolysis oxygen-supply wound repair patch of the invention.
The reference numbers illustrate:
the implementation, functional features and advantages of the objects of the present invention will be further explained with reference to the accompanying drawings.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that, if directional indications (such as up, down, left, right, front, and back … …) are involved in the embodiment of the present invention, the directional indications are only used to explain the relative positional relationship between the components, the movement situation, and the like in a specific posture (as shown in the drawing), and if the specific posture is changed, the directional indications are changed accordingly.
In addition, if there is a description of "first", "second", etc. in an embodiment of the present invention, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, if appearing throughout the text, "and/or" is meant to include three juxtaposed aspects, taking "A and/or B" as an example, including either the A aspect, or the B aspect, or both A and B satisfied aspects. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention.
Oxygen is an essential substance for life, can promote cell proliferation, tissue generation and tissue remodeling, and sufficient oxygen is one of the prerequisites for successful healing of the wound surface. In the related technology, the oxygen supply of the wound surface is insufficient (the oxygen carrying amount is small and the release is not easy), even oxygen deficiency, so that the wound surface is infected, and the repair and the healing of the wound surface are seriously hindered.
The invention provides an electrically-synergistic hydrolysis oxygen supply wound repair patch and a preparation method thereof.
In an embodiment of the present invention, referring to fig. 1, the electrically-collaborative hydrolytic oxygen supply wound repair patch 10 includes a substrate 100, an anode 210, a cathode 220, and a microneedle 300, where the substrate 100 has a first surface 101; the positive electrode 210 and the negative electrode 220 are both mounted on the substrate 100, and the positive electrode 210 and the negative electrode 220 are respectively used for being electrically connected with a power supply 400. With continued reference to fig. 1, the micropins 300 are located on the first surface 101; wherein the material of the substrate 100 is hydrogel.
Specifically, the substrate 100 may be a rectangular parallelepiped or a cube, and may be specifically set according to the size of the wound of the user. The substrate 100 has a first surface 101 and a second surface 102 opposite, the first surface 101 being opposite the skin of the user and the second surface 102 facing away from the skin of the user. Referring to fig. 1, a microneedle 300 is disposed on a first surface 101, the microneedle 300 is used for piercing the skin of a user, so as to facilitate oxygen permeation into the skin, when the electrically-assisted hydrolysis and oxygen supply wound repair patch 10 is not used, the first surface 101 may be provided with a protection frame, the protection frame may be in an annular structure, the height of the protection frame is greater than that of the microneedle 300, and the protection frame surrounds the periphery of the microneedle 300, so as to protect the microneedle 300. When the electrically-synergistic hydrolysis oxygen supply wound repair patch 10 needs to be used, the protection frame can be removed, so that the micro-needle 300 is exposed.
The second surface 102 may be provided with an adhesive tape, so that when the substrate 100 is attached to the skin of a user, the substrate 100 can be fixed on the skin to prevent the electrically-assisted hydrolysis oxygen-supplying wound repair patch 10 from falling off the skin. The second surface 102 may also be provided with a gauze, which may be adhesively bonded to the substrate 100 to secure the substrate 100 to the gauze, and the user may, in use, align the substrate 100 with the wound surface and then wrap the gauze around the user.
In order to perform the function of electrolyzing water to generate oxygen for the electrode, the material of the substrate 100 is hydrogel. The hydrogel contains a large amount of water, thereby supplying water to the electrolysis of the electrodes. In addition, as the hydrogel is of a porous structure, oxygen generated by water electrolysis of the electrode can be conveyed to the wound surface through the porous structure, so that more oxygen can be obtained from the wound surface, and the healing and the repair of the wound surface are facilitated.
Referring to fig. 1, the electrodes include a positive electrode 210 and a negative electrode 220, the positive electrode 210 and the negative electrode 220 are respectively used for being electrically connected with a power supply 400, that is, the positive electrode 210 is used for being connected with a positive terminal of the power supply 400, and the negative electrode 220 is used for being electrically connected with a negative terminal of the motor, so that the positive electrode 210 and the negative electrode 220 are electrified. Sufficient oxygen is provided through the electrolytic water reaction of the electrodes, the oxygen supply amount is large, the problem of insufficient oxygen supply in the related technology is solved, the oxygen of the electrically-synergetic hydrolysis oxygen supply wound repair patch 10 is produced at present, and the problem of low oxygen carrying efficiency by utilizing a carrier does not exist.
It can be understood that the positive electrode 210 and the negative electrode 220 can be electrode plates, so that the volume of the electrically synergistic hydrolysis oxygen supply wound repair patch 10 is reduced, the use by a user is facilitated, and the practicability of the electrically synergistic hydrolysis oxygen supply wound repair patch 10 is improved. The positive electrode 210 and the negative electrode 220 are mounted on the substrate 100, either within the substrate 100 or on the second surface 102.
The oxygen permeation efficiency is low due to the natural barrier action of the stratum corneum of the skin, in order to promote the permeability and absorption of oxygen to the skin. Referring to fig. 1, the microneedles 300 are mounted on the first surface 101 of the substrate 100, and the microneedles 300 have micron-sized tips with sharp tips, and may be arranged in an array. Because the microneedle 300 has a small size, the microneedle 300 only pierces the surface layer of the skin, and hardly generates pain, and meanwhile, a micropore formed by the microneedle 300 can automatically heal within hours, so that bleeding and wound are not caused, and painless minimally invasive operation can be realized.
It should be noted that the microneedle 300 may be made of a porous structure, so that oxygen generated by the positive electrode 210 and the negative electrode 220 permeates into the skin, and further promotes the repair of the wound surface. The micro needle 300 may be made of a material that can be absorbed and metabolized by the human body, such as a saccharide, and can be absorbed and metabolized by itself without being taken out by an operation even if the micro needle 300 is broken off in the body. The microneedles 300 may be integrally formed with the substrate 100, or may be separately provided.
According to the technical scheme, the anode 210 and the cathode 220 are arranged on the substrate 100, the substrate 100 is made of hydrogel materials and is electrically connected with the anode 210 and the cathode 220 through the power supply 400, and the anode 210 and the cathode 220 carry out electrolytic water reaction on water in the substrate 100 to generate oxygen, so that oxygen is actively provided for wound surfaces, and healing of the wound surfaces is accelerated. Meanwhile, the micro-needle 300 is arranged on the substrate 100, when the electrically-synergetic hydrolysis oxygen supply wound repair patch 10 is attached to the skin of a user, the micro-needle 300 can pierce the skin to reach the dermis layer, so that generated oxygen can enter the skin, the permeability and absorbability of the skin to the oxygen are further enhanced, the repair and healing of the wound are further promoted, and the micro-needle 300 is not in contact with the capillary vessels and nerve endings in the skin, so that the user acceptance is strong.
In order to provide more moisture to the electrodes, in one embodiment, the material of the microneedles 300 is hydrogel, saccharide, or polymer. The micro-needle 300 can be made of hydrogel materials, on one hand, more moisture is provided for the electrode, and the need of wound surface repair is met; on the other hand, oxygen generated by the electrodes on the substrate 100 can also permeate into the micro-needles 300, permeate into the skin through the micro-needles 300, cross the stratum corneum of the skin, and smoothly deliver the oxygen to the interior of the skin, so that the permeability and the absorbability of the skin to the oxygen are enhanced, and the wound repair is further promoted; in another aspect, the hydrogel has good biocompatibility and avoids potential damage to the skin caused by needle point breakage.
The micro-needle 300 may also be made of a saccharide material, so as to improve the biocompatibility of the electrically synergistic hydrolysis oxygen supply wound repair patch 10, and facilitate acceptance by a human body. In one embodiment, the carbohydrate material may include one or more of maltose, mannitol, trehalose, sucrose, xylitol, galactose, and polysaccharides. In addition, the micro-needle 300 may also be made of a polymer material, and in one embodiment, the polymer material may include one or more of polymethyl methacrylate (PMMA), polylactic acid (PLA), polylactic-co-glycolic acid (PLGA), polyglycolic acid (PGA), polycarbonate, cyclic olefin copolymer, polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), Polystyrene (PS), polymethyl vinyl ether-maleic anhydride, SU-8 photoresist.
The microneedles 300 may be all made of one material, or a hydrogel material may be used for a portion of the microneedles 300, a saccharide material may be used for a portion of the microneedles 300, a polymer material may be used for a portion of the microneedles 300, or a hydrogel, saccharide, or polymer material may be used for the microneedles 300.
Specifically, in one embodiment, the hydrogel of the substrate is a polyvinyl alcohol hydrogel; and/or the hydrogel of the microneedle is one or more of methacrylated gelatin, methacrylated hyaluronic acid and methacrylated chitosan.
The polyvinyl alcohol hydrogel (PVA) as the substrate material has good biocompatibility, micropores, strong shock absorption capacity, large elasticity and good fitting property. Methacrylated gelatin (GelMA) has uniform porosity, good structural stability, and can provide customizable mechanical properties. The methacryloylated hyaluronic acid (HAMA) and the methacryloylated Chitosan (CSMA) have good biocompatibility, can carry a medicine for administration, and improve the permeability of the medicine. The hydrogel can also be methacryloylated dextran, methacryloylated silk fibroin, water-soluble silk fibroin, methacryloylated carboxymethyl chitosan, etc.
Further, referring to fig. 1, in an embodiment, the microneedles 300 are hard hydrogels, and the substrate 100 is a soft hydrogel. Since the microneedles 300 are used to penetrate the skin, the microneedles 300 are hard hydrogels with respect to the substrate 100, and thus have certain hardness. It should be noted that the substrate 100 may also be a rigid hydrogel. It is understood that the shape of the microneedle 300 is various and may be a conical shape, a triangular pyramid shape or a quadrangular pyramid shape.
The micro needle may contain nano silver or antibacterial polypeptide such as dopamine branched polylysine (EPL-DA), so as to have antibacterial property, avoid breeding of bacteria or fungi, and further promote healing of wound surface wounds. The micro-needle can also contain growth factors for promoting cell growth or antibacterial drugs for further promoting wound repair.
The electrodes are arranged on the substrate 100 in various ways, and either the positive electrode 210 and the negative electrode 220 are located on the surface of the substrate 100 or neither is located on the surface of the substrate 100. Referring to fig. 1, in an embodiment, the positive electrode 210 and/or the negative electrode 220 are located in the substrate 100.
By positioning the positive electrode 210 and/or the negative electrode 220 in the substrate 100, the contact area between the substrate 100 and the positive electrode 210 or the negative electrode 220 is increased, the electrolytic water reaction of the positive electrode 210 and the negative electrode 220 is facilitated, the generation amount of oxygen is increased, and the supply of oxygen is further increased.
There are many arrangements of the electrodes in the substrate 100, and the positive electrode 210 and the negative electrode 220 may be both located on one side of the substrate 100 or located on two opposite sides of the substrate 100. With reference to fig. 1, in an embodiment, the positive electrode 210 and the negative electrode 220 are spaced in the thickness direction of the substrate 100, so as to further reduce the volume of the electrically-assisted hydrolysis oxygen-supplying wound repair patch 10, and facilitate the use of a user.
In another embodiment, the positive electrode 210 and the negative electrode 220 are spaced in the extending direction of the substrate 100, so as to reduce the thickness of the repair patch. Note that the positive electrode 210 and the negative electrode 220 may be provided at intervals in both the thickness and the extending direction.
Referring to fig. 1, in an embodiment, the electrically-assisted hydrolysis oxygen-supplying wound repair patch 10 further includes a power supply 400, and the power supply 400 is electrically connected to the positive electrode 210 and the negative electrode 220, respectively. The power supply 400 is used to supply electrical energy to the electrodes to perform the electrolytic water reaction to produce oxygen. The power supply 400 may be mounted on the substrate 100 or may be attached to the skin of the user by an adhesive. It can be understood that the electrically-assisted hydrolysis oxygen-supplying wound repair patch 10 may not provide the power supply 400, and the user may add the power supply 400 additionally when using the patch, and then electrically connect the positive electrode 210 and the negative electrode 220 with the power supply 400.
In one embodiment, the height of the microneedle 300 is less than 1 mm, so as to bring oxygen into the skin and not contact with the capillary vessels and nerve endings inside the skin, thereby reducing the pain of the user, and facilitating the acceptance of the user and the popularization of the product. In one embodiment, the height of the microneedle 300 may be 400 μm to 700 μm. The diameter of the bottom of the microneedle 300 may be 250 μm to 320 μm, thereby increasing a contact area of the microneedle 300 with the skin to facilitate permeation of oxygen.
There are various angles of the micropins 300, and referring to fig. 1, in one embodiment, the micropins 300 are perpendicular to the first surface 101 of the substrate 100, so as to facilitate piercing the skin of the user. In another embodiment, the top ends of the microneedles 300 at the two opposite sides can be arranged oppositely, that is, the top parts of the microneedles 300 at the left and right sides are arranged oppositely, and the microneedles 300 can be pressed inwards and clamped at the two sides of the wound surface, so that the wound can be shrunk and fixed, and the wound can be prevented from cracking again.
In an embodiment, an adhesive layer is further disposed on the first surface 101, and the adhesive layer is used for attaching the substrate 100 to the skin. This adhesive linkage can connect two micropins 300, also can be that the adhesive linkage is the loop configuration, and annular adhesive linkage ring is established in the micropin 300 periphery of in bank, and then fixes basement 100 on user's skin, avoids this electricity in coordination to hydrolyze oxygen suppliment surface of a wound restoration paster 10 and drops.
Referring to fig. 2, the present invention further provides a method for preparing an electrically synergistic hydrolysis oxygen supply wound repair patch 10, for preparing the electrically synergistic hydrolysis oxygen supply wound repair patch 10, including the following steps:
filling a microneedle 300 raw material solution in a mold cavity of a microneedle 300 template;
removing bubbles at room temperature under negative pressure or centrifuging to remove bubbles, wherein the centrifuging speed is 2000rpm to 4000 rpm;
heating and concentrating at 30-45 deg.C for 5-6 hr;
curing by ultraviolet light to obtain the microneedle 300 attached to the microneedle 300 template;
adding a substrate 100 raw material solution, a positive electrode 210 and a negative electrode 220 on the microneedle 300;
and (3) heating and drying for more than 12 hours, and demolding to obtain the electrically-synergistic hydrolysis oxygen supply wound repair patch 10.
Specifically, the microneedle 300 raw material solution and the substrate 100 raw material solution may be one or more of methacrylated gelatin, polyvinyl alcohol hydrogel, methacrylated hyaluronic acid, and methacrylated chitosan. The microneedle 300 raw material solution and the substrate 100 raw material solution may be the same or different. In order to increase the hardness of the microneedles 300, the content of the components of the hydrogel thereof may be increased. In one embodiment, the microneedle 300 raw material solution is a methacrylated hyaluronic acid solution (2% w/v), a methacrylated gelatin (5% w/v), and the substrate 100 raw material solution is a polyvinyl alcohol hydrogel (20% w/v).
The microneedle 300 template may be a PDMS (Polydimethylsiloxane) template, and the microneedle 300 raw material solution is dropped into the PDMS template, so that the microneedle 300 raw material solution is filled in the cavity of the PDMS template. In order to remove bubbles in the PDMS template, the bubbles are removed by vacuum at room temperature or by centrifugation, wherein the removal of bubbles at room temperature may be vacuum removal.
In the process of preparing the microneedles 300, the raw material solution of the microneedles 300 may be secondarily dropped after the heating concentration step, and secondarily heated and concentrated, so that the materials of the microneedles 300 are uniformly maintained. The specific heating time and heating temperature of the second heating concentration step may refer to the first heating concentration step. In order to accelerate the curing of the micro-needle 300, an ultraviolet curing mode is adopted, wherein the wavelength range of ultraviolet light is 300-420nm, and the illumination intensity of the ultraviolet light is 10-40nW/cm2Illumination time 100-.
After the preparation of the microneedle 300 is completed, the base 100 raw material solution may be dropped on the microneedle 300 to embed the positive electrode 210 and the negative electrode 220, and one end of the positive electrode 210 and the negative electrode 220 protrudes from the base 100 raw material solution to be connected by a power supply line. Further, heating and drying are carried out, the substrate 100 is solidified, and finally demoulding is carried out, so that the electrically-synergetic hydrolysis oxygen-supply wound repair patch 10 is obtained.
The above description is only an alternative embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications and equivalents of the present invention, which are made by the contents of the present specification and the accompanying drawings, or directly/indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (10)
1. An electrically-synergistic hydrolysis oxygen supply wound repair patch is characterized by comprising:
a substrate having a first surface;
the anode and the cathode are both arranged on the substrate and are respectively used for being electrically connected with a power supply;
microneedles located on the first surface;
wherein the material of the substrate is hydrogel.
2. An electrically synergistic hydrolytic oxygen supply wound repair patch as claimed in claim 1, wherein the material of the microneedles is hydrogel, saccharide or polymer.
3. An electrically synergistic hydrolytic oxygen supply wound repair patch as claimed in claim 2, wherein the hydrogel of the substrate is a polyvinyl alcohol hydrogel; and/or the presence of a gas in the gas,
the hydrogel of the microneedle is one or more of methacrylated gelatin (GelMA), methacrylated hyaluronic acid (HAMA) and methacrylated Chitosan (CSMA); alternatively, the saccharide of the microneedle comprises one or more of maltose, mannitol, trehalose, sucrose, xylitol, galactose and polysaccharide; alternatively, the polymer of the microneedle comprises one or more of Polymethylmethacrylate (PMMA), polylactic acid (PLA), polylactic-co-glycolic acid (PLGA), polyglycolic acid (PGA), polycarbonate, cyclic olefin copolymer, polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), Polystyrene (PS), polymethylvinylether-maleic anhydride.
4. An electrically synergistic hydrolytic oxygen supply wound repair patch as claimed in claim 3 wherein the microneedles are a rigid hydrogel and the substrate is a flexible hydrogel.
5. An electrically synergistic hydrolytic oxygen supply wound repair patch as claimed in claim 4, wherein the positive and/or negative electrode is/are located within the substrate.
6. The electrically-synergistic hydrolytic oxygen-supply wound repair patch as claimed in claim 5, wherein the positive electrode and the negative electrode are arranged at intervals in the extending direction of the substrate; alternatively, the first and second electrodes may be,
the positive electrode and the negative electrode are disposed at an interval in a thickness direction of the substrate.
7. The electrically synergistic hydrolysis oxygen supply wound repair patch according to any one of claims 1 to 6, further comprising a power supply, wherein the power supply is electrically connected with the positive electrode and the negative electrode respectively.
8. An electrically synergistic hydrolytic-oxygen supplying wound repair patch as claimed in claim 7, wherein the microneedles are less than 1 mm in height.
9. The electrically-assisted hydrolyzed oxygen-supplying wound repair patch as claimed in claim 7, wherein an adhesive layer is further disposed on the first surface, and the adhesive layer is used for attaching the substrate to skin.
10. A method for preparing an electric synergetic hydrolytic oxygen supply wound repair patch, which is used for preparing the electric synergetic hydrolytic oxygen supply wound repair patch as claimed in any one of claims 1 to 9, and is characterized by comprising the following steps:
filling a microneedle raw material solution in a mold cavity of the microneedle template;
removing bubbles at room temperature under negative pressure or centrifuging to remove bubbles, wherein the centrifuging speed is 2000rpm to 4000 rpm;
heating and concentrating at 30-45 deg.C for 5-6 hr;
curing by adopting ultraviolet light to obtain the micro-needle attached to the micro-needle template;
adding a base raw material solution, a positive electrode and a negative electrode on the microneedles;
and heating and drying for more than 12 hours, and demolding to obtain the electrically-synergistic hydrolysis oxygen supply wound repair patch.
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Application publication date: 20210723 |