CN113142456A - Lutein effervescent tablet for protecting eyes and relieving visual fatigue and preparation method thereof - Google Patents
Lutein effervescent tablet for protecting eyes and relieving visual fatigue and preparation method thereof Download PDFInfo
- Publication number
- CN113142456A CN113142456A CN202110493675.4A CN202110493675A CN113142456A CN 113142456 A CN113142456 A CN 113142456A CN 202110493675 A CN202110493675 A CN 202110493675A CN 113142456 A CN113142456 A CN 113142456A
- Authority
- CN
- China
- Prior art keywords
- percent
- lutein
- acid
- vitamin
- effervescent tablet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000001656 lutein Substances 0.000 title claims abstract description 43
- 235000012680 lutein Nutrition 0.000 title claims abstract description 43
- 229960005375 lutein Drugs 0.000 title claims abstract description 43
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 title claims abstract description 43
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 title claims abstract description 43
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 title claims abstract description 43
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 title claims abstract description 43
- 210000001508 eye Anatomy 0.000 title claims abstract description 27
- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 26
- 208000003464 asthenopia Diseases 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 67
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 55
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 54
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims abstract description 49
- 239000000843 powder Substances 0.000 claims abstract description 31
- 229960003080 taurine Drugs 0.000 claims abstract description 27
- 235000003095 Vaccinium corymbosum Nutrition 0.000 claims abstract description 26
- 235000017537 Vaccinium myrtillus Nutrition 0.000 claims abstract description 26
- 235000021014 blueberries Nutrition 0.000 claims abstract description 26
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 25
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 25
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 25
- 239000011718 vitamin C Substances 0.000 claims abstract description 25
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims abstract description 24
- 235000013734 beta-carotene Nutrition 0.000 claims abstract description 24
- 239000011648 beta-carotene Substances 0.000 claims abstract description 24
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims abstract description 24
- 229960002747 betacarotene Drugs 0.000 claims abstract description 24
- 229910000029 sodium carbonate Inorganic materials 0.000 claims abstract description 24
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims abstract description 24
- 239000004376 Sucralose Substances 0.000 claims abstract description 23
- 240000000851 Vaccinium corymbosum Species 0.000 claims abstract description 23
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims abstract description 23
- 235000019408 sucralose Nutrition 0.000 claims abstract description 23
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims abstract description 23
- 235000011478 zinc gluconate Nutrition 0.000 claims abstract description 23
- 239000011670 zinc gluconate Substances 0.000 claims abstract description 23
- 229960000306 zinc gluconate Drugs 0.000 claims abstract description 23
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 22
- 239000008101 lactose Substances 0.000 claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 20
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 19
- 239000000600 sorbitol Substances 0.000 claims abstract description 19
- 239000003826 tablet Substances 0.000 claims abstract description 16
- 229930003316 Vitamin D Natural products 0.000 claims abstract description 13
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 13
- 235000019166 vitamin D Nutrition 0.000 claims abstract description 13
- 239000011710 vitamin D Substances 0.000 claims abstract description 13
- 150000003710 vitamin D derivatives Chemical class 0.000 claims abstract description 13
- 229940046008 vitamin d Drugs 0.000 claims abstract description 13
- 235000005979 Citrus limon Nutrition 0.000 claims abstract description 11
- 244000131522 Citrus pyriformis Species 0.000 claims abstract description 11
- 239000004480 active ingredient Substances 0.000 claims abstract description 6
- 239000003337 fertilizer Substances 0.000 claims abstract 2
- 239000002245 particle Substances 0.000 claims description 27
- 235000017550 sodium carbonate Nutrition 0.000 claims description 23
- 239000000686 essence Substances 0.000 claims description 19
- 238000002156 mixing Methods 0.000 claims description 18
- 235000010356 sorbitol Nutrition 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 16
- 239000003513 alkali Substances 0.000 claims description 15
- 238000005303 weighing Methods 0.000 claims description 15
- 229960004543 anhydrous citric acid Drugs 0.000 claims description 14
- 238000001035 drying Methods 0.000 claims description 14
- 239000002253 acid Substances 0.000 claims description 12
- 229960004106 citric acid Drugs 0.000 claims description 12
- 238000007873 sieving Methods 0.000 claims description 12
- 235000013399 edible fruits Nutrition 0.000 claims description 11
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 8
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 235000005976 Citrus sinensis Nutrition 0.000 claims description 6
- 240000002319 Citrus sinensis Species 0.000 claims description 6
- 239000000853 adhesive Substances 0.000 claims description 6
- 230000001070 adhesive effect Effects 0.000 claims description 6
- 239000007779 soft material Substances 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 4
- 239000002585 base Substances 0.000 claims description 4
- 239000004067 bulking agent Substances 0.000 claims description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 4
- 238000003113 dilution method Methods 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 238000007689 inspection Methods 0.000 claims description 3
- 239000013067 intermediate product Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- 229930091371 Fructose Natural products 0.000 claims description 2
- 239000005715 Fructose Substances 0.000 claims description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- 239000001744 Sodium fumarate Substances 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims description 2
- 239000001361 adipic acid Substances 0.000 claims description 2
- 235000011037 adipic acid Nutrition 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 235000010323 ascorbic acid Nutrition 0.000 claims description 2
- 239000011668 ascorbic acid Substances 0.000 claims description 2
- 229960005070 ascorbic acid Drugs 0.000 claims description 2
- 235000003704 aspartic acid Nutrition 0.000 claims description 2
- -1 aspartic acid acidic compounds Chemical class 0.000 claims description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 2
- 239000004327 boric acid Substances 0.000 claims description 2
- 235000010338 boric acid Nutrition 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 235000010216 calcium carbonate Nutrition 0.000 claims description 2
- MSJMDZAOKORVFC-SEPHDYHBSA-L disodium fumarate Chemical compound [Na+].[Na+].[O-]C(=O)\C=C\C([O-])=O MSJMDZAOKORVFC-SEPHDYHBSA-L 0.000 claims description 2
- RRPFCKLVOUENJB-UHFFFAOYSA-L disodium;2-aminoacetic acid;carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O.NCC(O)=O RRPFCKLVOUENJB-UHFFFAOYSA-L 0.000 claims description 2
- 239000004220 glutamic acid Substances 0.000 claims description 2
- 235000013922 glutamic acid Nutrition 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- 235000016337 monopotassium tartrate Nutrition 0.000 claims description 2
- 239000011736 potassium bicarbonate Substances 0.000 claims description 2
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 2
- KYKNRZGSIGMXFH-ZVGUSBNCSA-M potassium bitartrate Chemical compound [K+].OC(=O)[C@H](O)[C@@H](O)C([O-])=O KYKNRZGSIGMXFH-ZVGUSBNCSA-M 0.000 claims description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 2
- 235000011181 potassium carbonates Nutrition 0.000 claims description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 2
- 229940086065 potassium hydrogentartrate Drugs 0.000 claims description 2
- 235000019294 sodium fumarate Nutrition 0.000 claims description 2
- 229940005573 sodium fumarate Drugs 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 235000002906 tartaric acid Nutrition 0.000 claims description 2
- 239000011975 tartaric acid Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 9
- 230000036541 health Effects 0.000 abstract description 7
- 239000007788 liquid Substances 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 abstract description 2
- 230000009977 dual effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 230000006872 improvement Effects 0.000 description 5
- 238000005457 optimization Methods 0.000 description 5
- 208000030533 eye disease Diseases 0.000 description 4
- 230000004438 eyesight Effects 0.000 description 4
- 244000077233 Vaccinium uliginosum Species 0.000 description 3
- 210000004958 brain cell Anatomy 0.000 description 3
- 239000003651 drinking water Substances 0.000 description 3
- 235000020188 drinking water Nutrition 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 208000002780 macular degeneration Diseases 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 208000002177 Cataract Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 206010064930 age-related macular degeneration Diseases 0.000 description 2
- 235000010208 anthocyanin Nutrition 0.000 description 2
- 239000004410 anthocyanin Substances 0.000 description 2
- 229930002877 anthocyanin Natural products 0.000 description 2
- 150000004636 anthocyanins Chemical class 0.000 description 2
- 230000004397 blinking Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 239000000543 intermediate Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000004379 myopia Effects 0.000 description 2
- 208000001491 myopia Diseases 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000001525 retina Anatomy 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- NCYCYZXNIZJOKI-IOUUIBBYSA-N 11-cis-retinal Chemical compound O=C/C=C(\C)/C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-IOUUIBBYSA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 108010016626 Dipeptides Proteins 0.000 description 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 1
- 206010013774 Dry eye Diseases 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000004330 Rhodopsin Human genes 0.000 description 1
- 108090000820 Rhodopsin Proteins 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000000971 hippocampal effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000036630 mental development Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 230000008832 photodamage Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/40—Effervescence-generating compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Botany (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to a health product, and in particular relates to a lutein effervescent tablet for protecting eyes and relieving visual fatigue and a preparation method thereof. The fertilizer consists of active ingredients, acid-base pairs and auxiliary materials: the active ingredients consist of the following components in parts by weight: blueberry powder: 1.5-5%, lutein: 1.3% -3%, vitamin C: 0.05-0.3%, taurine: 0.03% -0.2%, zinc gluconate: 0.03% -0.11%, beta-carotene: 0.01% -0.08% of vitamin D: 0.0002% -0.0009%, wherein the acid-base pair consists of the following components in parts by weight: citric acid: 25% -45%, sodium carbonate: 15% -35%; the auxiliary materials comprise the following components in parts by weight: sorbitol: 10% -30%, lactose: 10% -30%, edible essence: 1.0% -5%, sucralose: 0.1% -2%, lemon yellow: 0.015 to 0.06 percent. The invention adopts the form of tablets, is convenient for people to take and carry, and has the effects of safety, effectiveness and health care; the test results show that the eye-protection liquid has the dual functions of protecting eyes and relieving eye fatigue.
Description
Technical Field
The invention relates to a health product, and in particular relates to a lutein effervescent tablet for protecting eyes and relieving visual fatigue and a preparation method thereof.
Background
The effervescent tablet is a novel tablet developed and applied abroad in recent years. The effervescent tablet is different from the common tablet in that the effervescent tablet also contains an effervescent disintegrant, and a large amount of bubbles are generated immediately under the action of the effervescent disintegrant after the effervescent tablet is placed in drinking water, so that the tablet is rapidly disintegrated and melted, and sometimes the bubbles generated by disintegration can also cause the tablet to roll up and down in the water, thereby accelerating the disintegration and melting of the tablet. The gas generated during the disintegration of the tablet is partially dissolved in the drinking water, so that the drinking water has the aesthetic feeling like soda water when being drunk in the mouth. The effervescent tablet has the following advantages: is convenient for storage and carrying; the disintegration is fast, the taking is convenient, and the effect is fast; the bioavailability is high, and the clinical curative effect can be improved; is especially suitable for children, the elderly and patients with difficulty in swallowing pills; the flavored effervescent tablets have better taste, and good medicines are not bitter any more, so that patients are more willing to accept the flavored effervescent tablets.
Science and technology make our lives become rich, when we see that science and technology is advanced day by day, science and technology also brings many side effects to our people, especially our eyes, with the use of computers, the internet popularity rate reaches 25.5%, the current nationwide myopia ill population reaches 4.7 hundred million, children and teenagers are a huge population, the population still expands, the number of netizens in China reaches 4.7 hundred million, the radiation of computers to eyes causes more and more patients with eye diseases, the rate of disease of teenagers reading books at positive values reaches 50% -60% due to overuse of eyes, with the increase of age, the rate of disease of cataract of middle and old aged people and glaucoma and the like breaks through 6100 ten thousand, the rate of disease of AMD (age-related macular degeneration) above 50 years increases to nearly 2 hundred million people, and the middle-aged and old people with various eye diseases increase at the speed of 12% per year.
Accompanying with it, asthenopia (also called asthenopia), which is a common ophthalmic disease, causes dry eyes, sour eyes, blurred vision and even vision deterioration, and directly affects the work and life of people. The eyestrain is mainly caused by that when people concentrate on watching screens of electronic products such as televisions, computers or mobile phones and the like at ordinary times, the blinking frequency of eyes is reduced, the secretion of tears is correspondingly reduced, and meanwhile, a blinking screen strongly stimulates eyes. Eye fatigue can also cause and aggravate various eye diseases. Compared with the active medical treatment means, people pay more and more attention to daily eye nourishing and protecting.
Disclosure of Invention
The invention aims to provide a lutein effervescent tablet which can protect eyes and relieve eye fatigue, and also provides a preparation method of the lutein effervescent tablet.
The technical scheme provided by the invention is as follows: a lutein effervescent tablet for protecting eyes and relieving visual fatigue comprises active ingredients, acid-base pairs and auxiliary materials:
the active ingredients consist of the following components in parts by weight:
blueberry powder: 1.5 to 5 percent
Lutein: 1.3 to 3 percent
Vitamin C: 0.05 to 0.3 percent
Taurine: 0.03 to 0.2 percent
Zinc gluconate: 0.03 to 0.11 percent
Beta-carotene: 0.01 to 0.08 percent
Vitamin D: 0.0002 to 0.0009 percent
The acid-base pair comprises the following components in parts by weight:
citric acid: 25 to 45 percent
Sodium carbonate: 15 to 35 percent
The auxiliary materials comprise the following components in parts by weight:
sorbitol: 10 to 30 percent
Lactose: 10 to 30 percent
Edible essence: 1.0 to 5 percent
Sucralose: 0.1 to 2 percent
Lemon yellow: 0.015 to 0.06 percent
Further optimization and improvement of the scheme are as follows: the composition is as follows in parts by weight:
blueberry powder: 1.5 to 2.5 percent
Lutein: 1.5 to 2 percent
Vitamin C: 0.1 to 0.3 percent
Taurine: 0.08 to 0.15 percent
Zinc gluconate: 0.05 to 0.1 percent
Beta-carotene: 0.01 to 0.08 percent
Vitamin D: 0.0005 to 0.0008 percent
Citric acid: 30 to 40 percent
Sodium carbonate: 15 to 30 percent
Sorbitol: 15 to 25 percent
Lactose: 10 to 20 percent
Edible essence: 1.0 to 5 percent
Sucralose: 0.1 to 2 percent
Lemon yellow: 0.015 to 0.06 percent
Further optimization and improvement of the scheme are as follows: the composition is as follows in parts by weight:
blueberry powder: 2 percent of
Lutein: 1.5 percent
Vitamin C: 0.2 percent of
Taurine: 0.138 percent
Zinc gluconate: 0.082%
Beta-carotene: 0.05 percent
Vitamin D: 0.000758 percent
Citric acid: 36 percent
Sodium carbonate: 25 percent of
Sorbitol: 18 percent of
Lactose: 14 percent of
Edible essence: 2.5 percent
Sucralose: 0.5 percent
Lemon yellow: 0.03 percent
Further optimization and improvement of the scheme are as follows: the citric acid is an acidic compound, and can be replaced by one or more of tartaric acid, potassium hydrogen tartrate, sodium fumarate, adipic acid, malic acid, ascorbic acid, boric acid, glutamic acid or aspartic acid acidic compounds.
Further optimization and improvement of the scheme are as follows: the sodium carbonate is an alkaline compound and can be replaced by one or more of sodium bicarbonate, potassium carbonate, potassium bicarbonate, calcium carbonate or glycine sodium carbonate alkaline compounds.
Further optimization and improvement of the scheme are as follows: the sorbitol and lactose are both bulking agents, and can be replaced by one or more of sucrose, mannitol, maltose, fructose or natural fruit powder bulking agents.
A preparation method of lutein effervescent tablets for protecting eyes and relieving visual fatigue comprises the following steps:
(1) material picking: anhydrous citric acid, sodium carbonate, lactose, sorbitol, blueberry fruit powder, sweet orange powder essence, lutein, sucralose, vitamin C, taurine, zinc gluconate and beta-carotene which meet the standards and are qualified through inspection are taken; all raw and auxiliary materials enter a production clean area through an air lock chamber according to the Material in and out clean area operating regulations.
(2) Pretreatment: the anhydrous citric acid and the sodium carbonate are operated according to the operating regulations of material crushing and sieving, and the anhydrous citric acid and the sodium carbonate are crushed and respectively sieved by a sieve with 80 meshes for later use.
(3) Granulating with an acid source: respectively weighing anhydrous citric acid, lactose, blueberry fruit powder, lutein, sucralose, taurine, zinc gluconate and beta-carotene according to the formula amount, adding the anhydrous citric acid, the lactose, the blueberry fruit powder, the lutein, the sucralose, the taurine, the zinc gluconate and the beta-carotene into a high-speed wet granulator, rotating at 1200 r/min, mixing for 10 min, adding a proper amount of adhesive to prepare a mass-contact instant soft material, granulating by using a 20-mesh screen, controlling the drying temperature in an oven at 60-65 ℃, drying for 60 min, drying until the water content is less than 1%, sieving by using an 18-mesh screen, bagging the obtained acid particles, and weighing for later use.
(4) And (3) granulating by using an alkali source: respectively weighing sodium carbonate, sorbitol, lutein, sucralose, taurine, zinc gluconate and beta-carotene according to the formula amount, adding the mixture into a high-speed wet granulator at the rotating speed of 1200 r/min, mixing for 10 min, adding a proper amount of adhesive to prepare a kneaded mass-contact instant soft material, granulating by using a 20-mesh screen, controlling the drying temperature in an oven at 60-65 ℃, drying for 60 min until the water content is less than 1%, sieving by using an 18-mesh screen, bagging the obtained alkali particles, and weighing for later use.
(5) Total mixing: and (3) calculating the weight ratio of the obtained acid particles to the alkali particles to the feeding amount, multiplying the feeding amount of the formula by the ratio, weighing the sweet orange powder essence and the vitamin C according to the calculated value, uniformly mixing the blueberry powder essence and the vitamin C, sieving the mixture by a 60-mesh sieve, mixing the mixture with the dried alkali particles by an equal ratio dilution method to 5kg, mixing the mixture with the rest alkali particles and the obtained acid particles in a total mixer for 30min (18 revolutions per minute) to obtain total mixed particles, and filling the particles into a double-layer plastic bag for later use.
(6) Intermediate product detection: the detection is carried out according to the quality standard of effervescent tablet intermediates.
(7) Tabletting: tabletting the qualified total mixed granules at the room temperature of less than or equal to 25 ℃ and the relative humidity of less than or equal to 30 percent to obtain plain tablets (specification: 4 g/tablet), wherein the disintegration time is less than or equal to 5 minutes, and the hardness is more than or equal to 15N.
(8) Inner packaging: the tablets were tubulated.
Lutein and blueberry anthocyanin are visual nutrient elements which are found in the medical field at present and can directly reach the eyeground, the lutein is an indispensable important nutrient in a macular area of the retina of the eye and cannot be synthesized in a human body, the oxidation resistance and the blue light and ultraviolet ray absorption function of the lutein can prevent and treat eye diseases such as macular degeneration and the like, the lutein can increase the density of macular pigment, resist blue light damage, nourish visual cells and promote the generation of rhodopsin, so that the lutein can help to protect the eyesight and is particularly important for myopia; the blueberry anthocyanin is extracted from natural blueberries, has strong oxidation resistance, can eliminate free radicals, activate retinas and improve the visual acuity of human eyes; the elasticity of the micro blood vessels of the eyes is strengthened, the blood circulation is promoted, the normal pressure of the eyeballs is maintained, the effects of strengthening the eyesight and relieving the eye fatigue are achieved, and the two components have irreplaceable effects on the eyes. The invention combines the two, can well relieve eye fatigue while protecting eyesight.
Taurine (Taurine), also known as beta-aminoethanesulfonic acid, is chemically stable, exists in free form in the animal body, is the highest content of free amino acids in the body, and exists in the central nervous system in the form of small molecule dipeptides or tripeptides. Taurine can promote the synthesis of DNA and RNA of brain cells, increase the content of phosphatidylethanolamine of membranes and the utilization rate of the brain cells to protein, thereby promoting the development of the brain cells, especially the structure and function of hippocampal cells. Taurine can promote growth and mental development by increasing the availability of protein.
Beta-carotene is an antioxidant, has the function of detoxification, is an indispensable nutrient for maintaining human health, has obvious functions of resisting cancers, preventing cardiovascular diseases, cataract and oxidation, and further prevents various degenerative diseases caused by aging and senility.
The mixture of the vitamin C and the derivatives thereof can improve the physiological saturation level value of the vitamin C of a human body, improve the concentration and the reserve of blood and intracellular vitamin C of the human body, and is beneficial to meeting the physiological requirements of the human body on the absorption, utilization, metabolic balance and the like of the vitamin C; the single or compound vitamin C preparation is a clinical basic medicine or a daily health care nutrition enhancer and is widely applied to daily health care or prevention and treatment of various diseases.
Vitamin D drops is a medicine for preventing and treating rickets in children. Through a large number of evidence-based medical researches and basic researches, the vitamin D drops have certain curative effects on the treatment of cancer, hypertension, diabetes, tuberculosis and immunologic dysfunction.
The invention has the advantages of
The invention adopts the form of tablets, is convenient for people to take and carry, and has the effects of safety, effectiveness and health care; the test results show that the eye-protection liquid has double effects of protecting eyes and relieving eye fatigue, and has wide market prospect.
Detailed Description
The invention will be further illustrated with reference to specific embodiments. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Further, it should be understood that various changes or modifications of the present invention may be made by those skilled in the art after reading the teaching of the present invention, and such equivalents may fall within the scope of the present invention as defined in the appended claims.
Example 1:
blueberry powder: 2 percent of
Lutein: 1.5 percent
Vitamin C: 0.1 percent of
Taurine: 0.05 percent
Zinc gluconate: 0.05 percent
Beta-carotene: 0.04 percent
Vitamin D: 0.0005 percent
Citric acid: 30 percent of
Sodium carbonate: 25 percent of
Sorbitol: 18 percent of
Lactose: 20 percent of
Edible essence: 2.4 percent of
Sucralose: 0.82 percent
Lemon yellow: 0.0395 percent
The preparation method of the effervescent tablet comprises the following steps: (1) material picking: anhydrous citric acid, sodium carbonate, lactose, sorbitol, blueberry fruit powder, sweet orange powder essence, lutein, sucralose, vitamin C, taurine, zinc gluconate and beta-carotene which meet the standards and are qualified through inspection are taken; all raw and auxiliary materials enter a production clean area through an air lock chamber according to the Material in and out clean area operating regulations.
(2) Pretreatment: the anhydrous citric acid and the sodium carbonate are operated according to the operating regulations of material crushing and sieving, and the anhydrous citric acid and the sodium carbonate are crushed and respectively sieved by a sieve with 80 meshes for later use.
(3) Granulating with an acid source: respectively weighing anhydrous citric acid, lactose, blueberry fruit powder, lutein, sucralose, taurine, zinc gluconate and beta-carotene according to the formula amount, adding the anhydrous citric acid, the lactose, the blueberry fruit powder, the lutein, the sucralose, the taurine, the zinc gluconate and the beta-carotene into a high-speed wet granulator, rotating at 1200 r/min, mixing for 10 min, adding a proper amount of adhesive to prepare a mass-contact instant soft material, granulating by using a 20-mesh screen, controlling the drying temperature in an oven at 60-65 ℃, drying for 60 min, drying until the water content is less than 1%, sieving by using an 18-mesh screen, bagging the obtained acid particles, and weighing for later use.
(4) And (3) granulating by using an alkali source: respectively weighing sodium carbonate, sorbitol, lutein, sucralose, taurine, zinc gluconate and beta-carotene according to the formula amount, adding the mixture into a high-speed wet granulator at the rotating speed of 1200 r/min, mixing for 10 min, adding a proper amount of adhesive to prepare a kneaded mass-contact instant soft material, granulating by using a 20-mesh screen, controlling the drying temperature in an oven at 60-65 ℃, drying for 60 min until the water content is less than 1%, sieving by using an 18-mesh screen, bagging the obtained alkali particles, and weighing for later use.
(5) Total mixing: and (3) calculating the weight ratio of the obtained acid particles to the alkali particles to the feeding amount, multiplying the feeding amount of the formula by the ratio, weighing the sweet orange powder essence and the vitamin C according to the calculated value, uniformly mixing the blueberry powder essence and the vitamin C, sieving the mixture by a 60-mesh sieve, mixing the mixture with the dried alkali particles by an equal ratio dilution method to 5kg, mixing the mixture with the rest alkali particles and the obtained acid particles in a total mixer for 30min (18 revolutions per minute) to obtain total mixed particles, and filling the particles into a double-layer plastic bag for later use.
(6) Intermediate product detection: the detection is carried out according to the quality standard of effervescent tablet intermediates.
(7) Tabletting: tabletting the qualified total mixed granules at the room temperature of less than or equal to 25 ℃ and the relative humidity of less than or equal to 30 percent to obtain plain tablets (specification: 4 g/tablet), wherein the disintegration time is less than or equal to 5 minutes, and the hardness is more than or equal to 15N.
(8) Inner packaging: the tablets were tubulated.
Example 2
Blueberry powder: 3 percent of
Lutein: 2 percent of
Vitamin C: 0.2 percent of
Taurine: 0.1 percent of
Zinc gluconate: 0.06 percent
Beta-carotene: 0.05 percent
Vitamin D: 0.0005 percent
Citric acid: 30 percent of
Sodium carbonate: 27 percent of
Sorbitol: 24 percent of
Lactose: 10.3 percent of
Edible essence: 3 percent of
Sucralose: 0.15 percent
Lemon yellow: 0.05 percent
The process flow is the same as in example 1.
Example 3
Blueberry powder: 2 percent of
Lutein: 1.7 percent
Vitamin C: 0.3 percent of
Taurine: 0.15 percent
Zinc gluconate: 0.088%
Beta-carotene: 0.0609 percent
Vitamin D: 0.0006 percent
Citric acid: 35 percent of
Sodium carbonate: 20 percent of
Sorbitol: 20 percent of
Lactose: 16 percent of
Edible essence: 4.55 percent
Sucralose: 0.15 percent
Lemon yellow: 0.0005 percent
The process flow is the same as in example 1.
Example 4
Blueberry powder: 2 percent of
Lutein: 1.5 percent
Vitamin C: 0.2 percent of
Taurine: 0.138 percent
Zinc gluconate: 0.082%
Beta-carotene: 0.05 percent
Vitamin D: 0.000758 percent
Citric acid: 36 percent
Sodium carbonate: 25 percent of
Sorbitol: 18 percent of
Lactose: 14 percent of
Edible essence: 2.5 percent
Sucralose: 0.5 percent
Lemon yellow: 0.03 percent
The process flow is the same as in example 1.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, and other variations and modifications may be made without departing from the spirit of the invention as set forth in the claims.
Claims (7)
1. A lutein effervescent tablet for protecting eyes and relieving visual fatigue is characterized in that: the fertilizer consists of active ingredients, acid-base pairs and auxiliary materials:
the active ingredients consist of the following components in parts by weight:
blueberry powder: 1.5 to 5 percent
Lutein: 1.3 to 3 percent
Vitamin C: 0.05 to 0.3 percent
Taurine: 0.03 to 0.2 percent
Zinc gluconate: 0.03 to 0.11 percent
Beta-carotene: 0.01 to 0.08 percent
Vitamin D: 0.0002 to 0.0009 percent
The acid-base pair comprises the following components in parts by weight:
citric acid: 25 to 45 percent
Sodium carbonate: 15 to 35 percent
The auxiliary materials comprise the following components in parts by weight:
sorbitol: 10 to 30 percent
Lactose: 10 to 30 percent
Edible essence: 1.0 to 5 percent
Sucralose: 0.1 to 2 percent
Lemon yellow: 0.015 to 0.06 percent.
2. The lutein effervescent tablet for protecting eyes and relieving asthenopia according to claim 1, wherein: the composition is as follows in parts by weight:
blueberry powder: 1.5 to 2.5 percent
Lutein: 1.5 to 2 percent
Vitamin C: 0.1 to 0.3 percent
Taurine: 0.08 to 0.15 percent
Zinc gluconate: 0.05 to 0.1 percent
Beta-carotene: 0.01 to 0.08 percent
Vitamin D: 0.0005 to 0.0008 percent
Citric acid: 30 to 40 percent
Sodium carbonate: 15 to 30 percent
Sorbitol: 15 to 25 percent
Lactose: 10 to 20 percent
Edible essence: 1.0 to 5 percent
Sucralose: 0.1 to 2 percent
Lemon yellow: 0.015 to 0.06 percent.
3. The lutein effervescent tablet for protecting eyes and relieving asthenopia according to claim 1, wherein: the composition is as follows in parts by weight:
blueberry powder: 2 percent of
Lutein: 1.5 percent
Vitamin C: 0.2 percent of
Taurine: 0.138 percent
Zinc gluconate: 0.082%
Beta-carotene: 0.05 percent
Vitamin D: 0.000758 percent
Citric acid: 36 percent
Sodium carbonate: 25 percent of
Sorbitol: 18 percent of
Lactose: 14 percent of
Edible essence: 2.5 percent
Sucralose: 0.5 percent
Lemon yellow: 0.03 percent.
4. The lutein effervescent tablet for protecting eyes and relieving asthenopia according to any one of claims 1 to 3, wherein: the citric acid is an acidic compound, and can be replaced by one or more of tartaric acid, potassium hydrogen tartrate, sodium fumarate, adipic acid, malic acid, ascorbic acid, boric acid, glutamic acid or aspartic acid acidic compounds.
5. The lutein effervescent tablet for protecting eyes and relieving asthenopia according to any one of claims 1 to 3, wherein: the sodium carbonate is an alkaline compound and can be replaced by one or more of sodium bicarbonate, potassium carbonate, potassium bicarbonate, calcium carbonate or glycine sodium carbonate alkaline compounds.
6. The lutein effervescent tablet for protecting eyes and relieving asthenopia according to any one of claims 1 to 3, wherein: the sorbitol and lactose are both bulking agents, and can be replaced by one or more of sucrose, mannitol, maltose, fructose or natural fruit powder bulking agents.
7. A method for preparing lutein effervescent tablet for eye protection and asthenopia relief according to any one of claims 1 to 3, wherein the preparation method comprises the following steps: the method comprises the following steps:
(1) material picking: anhydrous citric acid, sodium carbonate, lactose, sorbitol, blueberry fruit powder, sweet orange powder essence, lutein, sucralose, vitamin C, taurine, zinc gluconate and beta-carotene which meet the standards and are qualified through inspection are taken; all raw and auxiliary materials enter a production clean area through an air lock chamber according to the Material in and out clean area operating regulations;
(2) pretreatment: the anhydrous citric acid and the sodium carbonate are operated according to the operating regulations of material crushing and sieving, and are respectively sieved by a 80-mesh sieve for later use after being crushed;
(3) granulating with an acid source: respectively weighing anhydrous citric acid, lactose, blueberry fruit powder, lutein, sucralose, taurine, zinc gluconate and beta-carotene according to the formula amount, adding the anhydrous citric acid, the lactose, the blueberry fruit powder, the lutein, the sucralose, the taurine, the zinc gluconate and the beta-carotene into a high-speed wet granulator, adding a proper amount of adhesive after mixing for 10 minutes to prepare a mass-contact instant soft material, granulating by using a 20-mesh screen, controlling the drying temperature in an oven at 60-65 ℃, drying for 60 minutes until the water content is less than 1%, sieving by using an 18-mesh screen, bagging the obtained acid particles, and weighing for later use;
(4) and (3) granulating by using an alkali source: respectively weighing sodium carbonate, sorbitol, lutein, sucralose, taurine, zinc gluconate and beta-carotene according to the formula amount, adding the mixture into a high-speed wet granulator at the rotation speed of 1200 r/min, mixing for 10 min, adding a proper amount of adhesive to prepare a kneaded mass-contact instant soft material, granulating by using a 20-mesh screen, controlling the drying temperature in an oven at 60-65 ℃, drying for 60 min until the water content is less than 1%, sieving by using an 18-mesh sieve, bagging the obtained alkali particles, and weighing for later use;
(5) total mixing: calculating the weight of the obtained acid particles and alkali particles and the proportion of the material amount, multiplying the material amount of the formula by the proportion, weighing the sweet orange powder essence and the vitamin C according to the calculated value, uniformly mixing the blueberry powder essence and the vitamin C, sieving the mixture by a 60-mesh sieve, mixing the mixture with the dried alkali particles by an equal ratio dilution method to 5kg, putting the rest alkali particles and the obtained acid particles into a total mixer together, mixing for 30min (18 revolutions per minute) to obtain total mixed particles, and filling the particles into a double-layer plastic bag for later use;
(6) intermediate product detection: detecting according to 'quality standard of effervescent tablet intermediate';
(7) tabletting: tabletting the qualified total mixed granules at room temperature of less than or equal to 25 ℃ and relative humidity of less than or equal to 30% to obtain plain tablets, wherein the disintegration time is less than or equal to 5 minutes, and the hardness is more than or equal to 15N;
(8) inner packaging: the tablets were tubulated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110493675.4A CN113142456A (en) | 2021-05-07 | 2021-05-07 | Lutein effervescent tablet for protecting eyes and relieving visual fatigue and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110493675.4A CN113142456A (en) | 2021-05-07 | 2021-05-07 | Lutein effervescent tablet for protecting eyes and relieving visual fatigue and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113142456A true CN113142456A (en) | 2021-07-23 |
Family
ID=76873753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110493675.4A Pending CN113142456A (en) | 2021-05-07 | 2021-05-07 | Lutein effervescent tablet for protecting eyes and relieving visual fatigue and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113142456A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114766580A (en) * | 2022-03-29 | 2022-07-22 | 四川一只老鹰集团股份有限公司 | Nutritional soft sweet for protecting eyesight health of children and preparation method thereof |
| CN115779024A (en) * | 2022-12-01 | 2023-03-14 | 成都爱佳眼科技有限公司 | Blueberry lutein ester effervescent tablet and preparation method thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102210474A (en) * | 2011-03-31 | 2011-10-12 | 无锡健特药业有限公司 | Eye-protecting brain-strengthening effervescent tablets |
| CN105011153A (en) * | 2015-06-19 | 2015-11-04 | 北京元莱健康管理有限公司 | Composition capable of promoting development of eyes and brains of children and alleviating asthenopia and preparation method of composition |
| CN105011154A (en) * | 2015-06-19 | 2015-11-04 | 北京元莱健康管理有限公司 | Composition for relieving asthenopia of the adolescent and promoting memory and preparation method of the composition for relieving asthenopia of the adolescent and promoting memory |
| CN108969503A (en) * | 2017-05-31 | 2018-12-11 | 江苏汉典生物科技股份有限公司 | Multivitamin effervescent tablet and preparation method thereof |
| CN109805400A (en) * | 2017-11-20 | 2019-05-28 | 威海紫光科技园有限公司 | A kind of cowberry lutein health food for alleviating visual fatigue |
| CN110771687A (en) * | 2019-08-22 | 2020-02-11 | 杭州娃哈哈科技有限公司 | Blueberry goat milk micro-effervescent tablet and preparation method thereof |
| CN110810838A (en) * | 2018-08-10 | 2020-02-21 | 洋县朱鹮有机产品技术协会 | Blueberry extract effervescent tablet |
| CN110897158A (en) * | 2019-12-09 | 2020-03-24 | 山东国和堂制药有限公司 | Edible blueberry lutein ester tablet |
-
2021
- 2021-05-07 CN CN202110493675.4A patent/CN113142456A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102210474A (en) * | 2011-03-31 | 2011-10-12 | 无锡健特药业有限公司 | Eye-protecting brain-strengthening effervescent tablets |
| CN105011153A (en) * | 2015-06-19 | 2015-11-04 | 北京元莱健康管理有限公司 | Composition capable of promoting development of eyes and brains of children and alleviating asthenopia and preparation method of composition |
| CN105011154A (en) * | 2015-06-19 | 2015-11-04 | 北京元莱健康管理有限公司 | Composition for relieving asthenopia of the adolescent and promoting memory and preparation method of the composition for relieving asthenopia of the adolescent and promoting memory |
| CN108969503A (en) * | 2017-05-31 | 2018-12-11 | 江苏汉典生物科技股份有限公司 | Multivitamin effervescent tablet and preparation method thereof |
| CN109805400A (en) * | 2017-11-20 | 2019-05-28 | 威海紫光科技园有限公司 | A kind of cowberry lutein health food for alleviating visual fatigue |
| CN110810838A (en) * | 2018-08-10 | 2020-02-21 | 洋县朱鹮有机产品技术协会 | Blueberry extract effervescent tablet |
| CN110771687A (en) * | 2019-08-22 | 2020-02-11 | 杭州娃哈哈科技有限公司 | Blueberry goat milk micro-effervescent tablet and preparation method thereof |
| CN110897158A (en) * | 2019-12-09 | 2020-03-24 | 山东国和堂制药有限公司 | Edible blueberry lutein ester tablet |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114766580A (en) * | 2022-03-29 | 2022-07-22 | 四川一只老鹰集团股份有限公司 | Nutritional soft sweet for protecting eyesight health of children and preparation method thereof |
| CN115779024A (en) * | 2022-12-01 | 2023-03-14 | 成都爱佳眼科技有限公司 | Blueberry lutein ester effervescent tablet and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102210474B (en) | Eye-protecting brain-strengthening effervescent tablets | |
| CN102150724B (en) | Functional mixture for refreshing and remitting physical fatigue and visual fatigue and application thereof | |
| CN103432161B (en) | Multivitamin mineral effervescent tablet and preparation method thereof | |
| EP3868367A1 (en) | Micro-effervescent buccal tablet and preparation method thereof | |
| CN113142456A (en) | Lutein effervescent tablet for protecting eyes and relieving visual fatigue and preparation method thereof | |
| US10647669B2 (en) | Composition containing lutein/lutein ester and applications thereof | |
| CN107252109A (en) | Function nutrition hardening agent composition and preparation method thereof | |
| KR20080101407A (en) | Method for development of processing product using corn and corn silk | |
| CN106387585A (en) | Taurine electrolyte sports solid beverage and production technology thereof | |
| CN105011154A (en) | Composition for relieving asthenopia of the adolescent and promoting memory and preparation method of the composition for relieving asthenopia of the adolescent and promoting memory | |
| WO2018077311A1 (en) | Composition for relieving eye strain and preparation method therefor | |
| CN104382004A (en) | Acerola cherry VC effervescent tablet | |
| CN110897158A (en) | Edible blueberry lutein ester tablet | |
| CN102823874A (en) | Pomegranate effervescent tablets and preparation method thereof | |
| US20190008914A1 (en) | Black chinese wolfberry effervescent tablet and preparation method thereof | |
| CN111838500A (en) | Ginseng pine needle effervescent tablet and preparation method thereof | |
| CN108041609B (en) | Food composition with functions of relieving visual fatigue and preventing myopia and preparation method thereof | |
| CN109527325A (en) | A kind of sports type effervescent tablet and preparation method thereof | |
| CN106387596A (en) | Effervescent tablets capable of refreshing mind and restoring consciousness and preparation method of effervescent tablets | |
| CN107373273B (en) | Adult type multivitamin mineral effervescent tablet and preparation method thereof | |
| CA2865209A1 (en) | Methods and compositions for enhancement of vision performance | |
| CN102210453A (en) | Effervescent chewing gum and preparation method thereof | |
| CN109043279A (en) | Ginseng effervescent tablet and preparation method thereof | |
| CN113995143A (en) | Micromolecular bird nest bubble water with effects of maintaining beauty and keeping young and preparation method thereof | |
| CN104667254A (en) | Fish oligopeptide effervescent tablet and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210723 |
|
| RJ01 | Rejection of invention patent application after publication |