CN113116957A - Michelia figo extract for removing acne and preparation method and application thereof - Google Patents
Michelia figo extract for removing acne and preparation method and application thereof Download PDFInfo
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- CN113116957A CN113116957A CN201911405883.3A CN201911405883A CN113116957A CN 113116957 A CN113116957 A CN 113116957A CN 201911405883 A CN201911405883 A CN 201911405883A CN 113116957 A CN113116957 A CN 113116957A
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Images
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A01D91/00—Methods for harvesting agricultural products
- A01D91/04—Products growing above the soil
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- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
- A21D13/00—Finished or partly finished bakery products
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- A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
- A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
- A21D2/36—Vegetable material
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61P17/10—Anti-acne agents
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
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- A—HUMAN NECESSITIES
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- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention provides a michelia figo extract for removing acne, a preparation method and application thereof. The michelia figo extract comprises an extract obtained by extracting and purifying michelia figo. The preparation method comprises placing Michelia figo in shade place, and naturally drying; extracting and purifying the naturally dried michelia figo to obtain a michelia figo extract; wherein the michelia figo comprises michelia figo in the remote mountain which is picked in 4-15 days after blooming. The application of the michelia figo extract comprises the application in preparing perfumed soap or bath foam, the application in preparing antifungal agents, anti-inflammatory agents, aromatic agents and the like, and the application in foods, masks and the like. The beneficial effects of the invention can include: the preparation method is simple and convenient and has low cost; the michelia figo extract has quick curative effect on acne, small side effect and low recurrence rate, and can effectively solve the problems that the acne is placed on a large face for a long time, and unsightly traces are left after large-area outbreak and scabbing.
Description
Technical Field
The invention relates to the field of medical and cosmetics, in particular to a michelia figo extract for removing acne and a preparation method and application thereof.
Background
Acne is a chronic inflammation of hair follicles and sebaceous glands, and mainly occurs in the greasy areas of the face, chest and back, etc. Self-limiting, skin lesions with multiple shapes, such as acne, papule, pustule, and nodule. Acne is caused by increased sebum secretion caused by endocrine dysfunction and abnormal sebaceous gland activity of human bodies, and excessive keratinization of hair follicle mouths, so that sebum outflow is not smooth, and abnormal flora is bred to cause diseases.
With the pursuit of beauty, acne removing products on the market are more and more, but most of the products contain chemical substances and even hormone components, so that the products have certain irritation to the skin, and the acne is repeatedly aggravated and even has anaphylactic reaction after being used for a long time.
Disclosure of Invention
In view of the deficiencies in the prior art, it is an object of the present invention to address one or more of the problems in the prior art as set forth above. For example, one of the objects of the present invention is to provide a safe and effective michelia figo extract for removing acne, a preparation method and applications thereof.
In order to achieve the above objects, the present invention provides, in one aspect, a michelia figo extract for removing acne. The michelia figo extract comprises an extract obtained by extracting and purifying michelia figo in the mountainous region.
In an exemplary embodiment of the michelia figo extract for removing acne of the present invention, the michelia figo in the deep mountains may include flowers picked within 4 to 15 days of blooming, i.e., within 4 to 15 days counted from when a bud opens into a petal.
In one exemplary embodiment of the michelia figo extract for removing acne of the present invention, the michelia profundus can include michelia profundus having no water attached to the surface, such as michelia profundus dried in the shade. Further, the michelia profunda may include fresh michelia profunda with no water attached to the surface.
In an exemplary embodiment of the michelia figo extract for removing acne of the present invention, the extracting and purifying may comprise: soaking michelia figo in an organic extracting solution to obtain a first extracting solution; removing solid substances from the first extract; and distilling and purifying the first extracting solution after the solid substances are removed to obtain the michelia figo extract.
In an exemplary embodiment of the michelia figo extract for removing acne of the present invention, the extracting and purifying may comprise: steaming Michelia figo with water vapor, and collecting the liquid after the water vapor to obtain a second extracting solution; and distilling and purifying the second extracting solution to obtain the michelia figo extract.
In an exemplary embodiment of the michelia figo extract for removing acne of the present invention, the extracting and purifying may comprise: placing the michelia figo in distilled water, and performing microwave treatment for 12-18 min to obtain a third extracting solution; removing solid substances from the third extractive solution; and distilling and purifying the third extracting solution after the solid matters are removed to obtain the michelia figo extract.
The invention also provides a preparation method of the michelia figo extract for removing the acne. The method may comprise the steps of: removing water attached to the surface of the michelia figo; extracting and purifying the michelia figo after removing the water attached to the surface to obtain a michelia figo extract; wherein the michelia figo can comprise michelia figo in the mountainous region.
In yet another aspect, the present invention provides a method for removing acne from a michelia figo extract. For example, the use of an extract of michelia figo in the preparation of soap and/or body wash; use in the preparation of at least one of an antifungal agent, an anti-inflammatory agent, a fragrance, an antioxidant, and a medicament; application in facial mask or food, etc.
Compared with the prior art, the beneficial effects of the invention can include: the preparation method is simple and convenient and has low cost; after the patient uses the michelia figo extract, the large area of acne can be avoided, the maturation of the acne can be accelerated, and the problems of scar retention on the face and the like can be reduced.
Drawings
The above and other objects and features of the present invention will become more apparent from the following description taken in conjunction with the accompanying drawings, in which:
FIG. 1 shows visual evaluation of the efficacy of four Michelia figo extracts in an example of the present invention on acne treatment;
FIG. 2 shows the statistics of no more abscesses in groups A-D in an example of the invention;
FIG. 3 shows the statistical result of the reduction of the individual acne cure time by at least two thirds in groups A-D of the present invention;
FIG. 4 shows the statistics of groups A-D of the present invention for finding that acne may not ulcerate immediately after treatment;
FIG. 5 shows the statistics of groups A-D of long term use of the article in an example of the present invention without substantial long term acne;
FIG. 6 shows the statistics of the groups A-D articles of use of the present invention after healing with no or substantially no scar;
fig. 7 shows the cases of group a-D neonatal acne in the present example.
Detailed Description
Hereinafter, the michelia figo extract for removing acne, the preparation method and the application thereof according to the present invention will be described in detail with reference to the accompanying drawings and exemplary embodiments.
In one aspect, the invention provides a preparation method of a michelia figo extract for removing acne.
In one exemplary embodiment of the present invention, the preparation method may include: extracting and purifying the michelia figo to obtain the michelia figo extract.
Wherein the variety of the michelia figo is michelia figo in the mountainous region. The blooming time of the michelia figo on the mountains can be 30-40 days, and further, the picking flowering period of the michelia figo on the mountains can be 4-15 days, so that the effect of corresponding products is better, for example, 7 +/-2 days.
In this embodiment, before the extracting and purifying, the method further includes: the water attached to the surface of the michelia figo can be removed, for example, by placing the michelia figo in a cool place and naturally drying the michelia figo, so that the water attached to the flower can be removed.
If the flowers are dried in the sun or the like, the effective components in the flowers are destroyed to some extent.
In this embodiment, the method may further comprise the step of washing the michelia figo to remove impurities from the michelia figo. In this embodiment, the extraction of michelia figo during the preparation process may include any one of the following three ways.
(1) Soaking and purifying.
Soaking Michelia figo with organic extractive solution to obtain first extractive solution with dark yellow color. Wherein the organic solvent may comprise at least one of alcohol, methanol, and diethyl ether. The soaking time can be 24-72 h, the soaking time is set in the time range, the extraction effect is best, less effective components can be extracted below 24h, and the flow period is long and the effective extraction amount is not increased obviously any more above 72 h. Wherein, the concentration of the alcohol can be 45-75%.
Removing solid substances from the first extractive solution to avoid influence of solid impurities. This may be achieved, for example, by filtering.
And distilling and purifying the first extracting solution after the solid substances are removed to obtain the michelia figo extract.
(2) Cooking and purification
Steaming Michelia figo with water vapor, and collecting the liquid after water evaporation to obtain a second extract. For example, a michelia may be placed in a perforated vessel provided with a steam inlet and a liquid outlet, the liquid outlet being located at the bottom of the vessel; water vapor is poured into the vessel through the vapor inlet port and the effluent liquid is collected from the liquid outlet port.
And distilling and purifying the second extracting solution to obtain the michelia figo extract.
(3) Microwave extraction and purification
Soaking Michelia figo in distilled water, and performing microwave treatment for 12-18 min, such as 15 min; the solids are removed and then purified by distillation.
In another aspect, the invention also provides a michelia figo extract for removing acne. The michelia figo extract comprises the extract prepared by the preparation method. The Michelia figo extract may be in a viscous state. The Michelia figo extract can be used directly for preventing or treating acne, or can be mixed with organic solvent (such as alcohol) for later use.
The michelia figo extract of the present invention has excellent effects on treating or preventing acne.
In yet another aspect, the present invention provides the use of an extract of michelia figo for the removal of acne.
For example, the michelia figo extract of the present invention can be applied to soap, bath foam, etc., which can increase the fragrance of the skin, prevent bacterial and viral infection, reduce the probability of acne, and has mild effect and no harm to human body. For example, it may be used in the preparation of toilet soaps.
The michelia figo extract of the present invention can also be applied to antifungal agents, anti-inflammatory agents, fragrances, antioxidants, medicaments, and the like. For example, the use in the preparation of the above-mentioned medicament is possible.
The michelia figo extract can also be applied to a mask, so that acne can be prevented, the existing acne can be well treated, and the michelia figo extract has good moistening and smoothing effects on skin.
The michelia figo extract can also be directly used for foods, including edible products and drinks, such as cakes or biscuits, can increase the aroma of the foods and improve the mood, and has obvious mood improvement and more relaxed mood for most patients with depression tendency.
In order that the above-described exemplary embodiments of the invention may be better understood, further description thereof with reference to specific examples is provided below.
The experiment uses four types of michelia figo extracts, namely a michelia figo fresh flower product (product A) in the mountainous region for removing water attached to the surface of a flower, a michelia figo dried flower product (product B) in the mountainous region, a michelia figo fresh flower product (product C) in the Lechang region and a michelia figo dried flower product (product D) in the Yunnan region, wherein the water content of the michelia figo dried flower in the mountainous region and the michelia figo dried flower in the Yunnan region can be below 20%. Wherein, the michelia figo in the remote mountains adopted in the preparation of A and B are picked within 4-15 days of blooming.
The preparation method of the four products comprises the following steps: firstly, respectively taking 20-300 g of fresh flowers corresponding to the four products for later use; secondly, airing the fresh flowers corresponding to the product A in the shade, and airing the fresh flowers corresponding to the products B and D in the sun; step three, respectively placing the four flowers into a container, soaking the four flowers for 72 hours by using alcohol with certain concentration, then removing solid substances, and purifying the rest soaking solution to obtain an extract for later use; fourthly, sterilizing the respective extracts; and step five, mixing the obtained extracts with 45% alcohol according to the mass ratio of 2:99 to obtain products A-D for later use.
Searching 54 test volunteers with acne on the face, and dividing the test volunteers into four groups, wherein the A group comprises 30, the B group comprises 8, the C group comprises 8 and the D group comprises 8; the prepared extract products A, B, C, D are respectively corresponding to A, B, C, D four groups, and are observed and recorded during the use process. The use and observation period was 2 months.
Recording observations included:
(1) recording and observing a visual evaluation of the four michelia figo extracts after use, namely: three modes of basic ineffectiveness, basic effectiveness and good effect are adopted, the statistical conditions are shown in table 1 and figure 1, and as can be seen from table 1 and figure 1, the product A has the best effect, the michelia in the mountains is second to the best effect after drying, and the michelia in the Lechang and the michelia in the Yunnan are almost ineffective on acne.
Wherein, the above-mentioned basic ineffectiveness means: through objective comparison before and after use, the evolution speed, color change, evolution process and number of newly-generated acnes are not changed or almost not changed; substantially effective means: the evolution speed, the color change, the evolution process and the number of newly-generated acnes are changed before and after use, but the problems are not fundamentally solved and the requirements of testers are not met; the effect is good, namely the evolution speed, the color change, the evolution process and the number of newly generated acnes are greatly changed before and after use, the problems are basically solved, and the requirements of users are met.
In table 1, "michelia profunda (30)" corresponds to group a, "michelia profunda (8)" corresponds to group B, "michelia chapensis (8)" corresponds to group C, "michelia profunda (8)" corresponds to group D.
(2) After the application, if the treatment effect is better, the situation of abscess caused by acne is greatly changed: under the natural condition without medicine, the acne is firstly red spots, then the red spots are enlarged, then the red spots are whitened to be abscesses, then the scabs are formed, and finally the pruritus is cured.
After use, statistics on the abscess effect are shown in fig. 2 and table 1, and the number of people in A, B, C, D group who no longer had abscesses was 29, 1, and 2, respectively, and the percentages were: 96.7%, 12.5% and 25%. The statistical results show that product A has the best effect on abscess treatment.
(3) Without any other medicine, the time from occurrence to recovery of acne takes 7 to 15 days at the shortest. The time period during which acne healed in A, B, C, D groups was strictly recorded. According to the observation and test process, the group A can complete the whole healing process within almost 2 days, if the healing time is reduced by 6 days, the healing time of the group A is shortened by at least two thirds, and the statistical results can be seen in table 1 and fig. 3. It should be noted that the particularly important changes after using the product A are that the individual area of acne is obviously reduced and the red and swollen degree is greatly reduced.
(4) Table 1 and fig. 4 show the efficacy of products A, B, C and D immediately after treatment for acne found early. If the product has good curative effect, the acne is discovered as soon as possible and treated immediately, the natural development process of the acne can be stopped, and most of acne grains can not be festered any more, and the red spots naturally disappear. According to the statistical data of the testers, the product A has the best curative effect after the immediate treatment of the acne which is discovered early.
(5) When products A, B, C and D are used for a long time, the incidence rate of acne and acne grains is greatly reduced and even basically does not occur any more if the treatment effect is good. Table 1 and fig. 5 show the effect after prolonged use, with the best therapeutic effect of product a after prolonged use.
(6) After the acne is cured by using the medicine, if the treatment effect is excellent, the color of scars is greatly reduced, or the scars are basically free of scars after the acne is cured. But under the condition of generally no medicine or poor medicine effect, the acne is generally a dark scar. According to the effectiveness, A, B, C and D statistics shown in Table 1 and FIG. 6, product A gave the best treatment results, with approximately 63.3% of the patients having substantially no marks on their faces after use.
(7) Table 1 and fig. 7 show the new acne counted over 2 months on trial. If the treatment effect is good, the newly added data of the acne is greatly reduced compared with the data before the product is used, for the reason, four calibers are statistically adopted, namely more than 4, more than 3, less than 2 and less than 1 (1 and 0) are newly added every day, and the treatment effect of the product A is best according to the statistical data of testers.
TABLE 1
In summary, the michelia figo extract for removing acne, the preparation method and the application thereof have the advantages that:
(1) the invention uses natural plants and adopts effective extraction and purification methods to obtain products which are truly green to human and environment.
(2) The michelia figo extract can really and effectively solve the two problems of unsightly marks left after acne is placed on a face for a long time and scabs, and can also be timely found and timely treated to provide a beautiful smiling face for young people.
(3) The michelia figo extract can prevent the occurrence of acne and has the advantages of quick curative effect, small side effect, low recurrence rate and the like on the generated acne.
(4) The preparation method is simple and convenient and has low cost.
(5) The michelia figo extract has excellent curative effect, can greatly improve the confidence of a demanding party on treatment effectiveness, and can obviously enhance the expected reliability after use.
(6) The michelia figo extract has fundamental control function for controlling the large-area development of patients, and can thoroughly change the original situation of stranded hands.
Although the present invention has been described above in connection with exemplary embodiments, it will be apparent to those skilled in the art that various modifications and changes may be made to the exemplary embodiments of the present invention without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (10)
1. A michelia figo extract for removing acne is characterized in that the michelia figo extract comprises an extract obtained by extracting and purifying michelia figo in the mountainous region.
2. The michelia figo extract for removing acne as claimed in claim 1, wherein said michelia figo in the mountains comprises flowers picked within 4-15 days of blooming.
3. The michelia figo extract for removing acne as claimed in claim 1, wherein said michelia figo makino comprises michelia figo makino without water attached to the surface.
4. The michelia figo extract for removing acne as claimed in claim 1, wherein said extracting and purifying comprises:
soaking michelia figo in an organic extracting solution to obtain a first extracting solution;
removing solid substances from the first extract;
and distilling and purifying the first extracting solution after the solid matters are removed to obtain the michelia figo extract.
5. The michelia figo extract for removing acne as claimed in claim 1, wherein said extracting and purifying comprises:
steaming Michelia figo with water vapor, and collecting the liquid after the water vapor to obtain a second extracting solution;
and distilling and purifying the second extracting solution to obtain the michelia figo extract.
6. The michelia figo extract for removing acne as claimed in claim 1, wherein said extracting and purifying comprises:
placing the michelia figo in distilled water, and performing microwave treatment for 12-18 min to obtain a third extracting solution;
removing solid substances from the third extractive solution;
and distilling and purifying the third extracting solution after the solid matters are removed to obtain the michelia figo extract.
7. A method for preparing a michelia figo extract for removing acne, the method comprising the steps of:
removing water attached to the surface of the michelia figo;
extracting and purifying the michelia figo after removing the water attached to the surface to obtain a michelia figo extract; wherein the content of the first and second substances,
the Michelia figo comprises Michelia figo in the mountainous region.
8. Use of the michelia figo extract for removing acne according to any one of claims 1 to 6 in the preparation of soap and/or bath foam.
9. Use of the michelia figo extract for removing acne according to any one of claims 1 to 6 in the preparation of at least one of antifungal agents, anti-inflammatory agents, fragrances, antioxidants and medicaments.
10. Use of the michelia figo extract for removing acne as claimed in claim 7 in food or facial mask.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080260869A1 (en) * | 2007-04-19 | 2008-10-23 | Mary Kay Inc. | Magnolia extract containing compositions |
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2019
- 2019-12-30 CN CN201911405883.3A patent/CN113116957A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080260869A1 (en) * | 2007-04-19 | 2008-10-23 | Mary Kay Inc. | Magnolia extract containing compositions |
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| S. LUANGNARUMITCHAI: "Antimicrobial Activity of Essential Oils Against Five Strains of Propionibacterium acnes", 《MAHIDOL UNIVERSITY JOURNAL OF PHARMACEUTICAL SCIENCES》 * |
| 方小平: "不同提取方法对深山含笑挥发性成分的影响", 《贵州农业科学》 * |
| 杨波华: "含笑花精油的抑菌活性及其化学成分分析", 《湖南农业大学学报（自然科学版）》 * |
| 沈文彤: "植物成分对痤疮杆菌抑菌作用研究进展", 《辽宁中医药大学》 * |
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