CN113106623A

CN113106623A - Anti-infection composite layer medical dressing, bed sheet and application

Info

Publication number: CN113106623A
Application number: CN202110369931.9A
Authority: CN
Inventors: 钱秋梅; 王敏
Original assignee: Ningbo Yintianzhixu Biotechnology Co ltd
Current assignee: Shenzhen Yiqiu Medical Textile Technology Co.,Ltd.
Priority date: 2021-04-07
Filing date: 2021-04-07
Publication date: 2021-07-13
Anticipated expiration: 2041-04-07
Also published as: CN113106623B

Abstract

The invention discloses an anti-infection composite layer medical dressing, a bed sheet and application; the anti-infection composite layer medical dressing takes the chitosan fiber layer as the outer layer of the dressing and takes the antibacterial fiber layer as the inner layer of the dressing to be in contact with the skin of a human body; the anti-infection composite layer medical bed sheet is characterized in that the chitosan fiber layer is the outer layer of the bed sheet, the antibacterial fiber layer is the inner layer of the bed sheet and is contacted with the skin of a human body or an animal; the antibacterial fiber layer is made of 1,3, 7-trihydroxy-2-isopentenyl xanthone modified cellulose non-woven fabric. The antibacterial fiber cloth has excellent antibacterial and anti-infection properties, and is used as the inner layer of the composite layer medical dressing, so that the dressing has excellent antibacterial and anti-infection properties and better moisture absorption rate and moisture retention rate, and meanwhile, the composite layer medical dressing has better air permeability; the composite medical bed sheet inner layer is used as a composite medical bed sheet inner layer, so that the bed sheet has excellent antibacterial and anti-infection performance, softness, better water washing resistance, long-acting performance and excellent deodorization performance.

Description

Anti-infection composite layer medical dressing, bed sheet and application

Technical Field

The invention belongs to the field of medical materials, and particularly relates to an anti-infection composite layer medical dressing, a bed sheet and application.

Background

In recent years, skin is frequently damaged due to wounds, abrasions, burns, surgical incisions, diabetic ulcers and other reasons, immunity of the damaged skin is reduced, the damaged skin is easily infected by germs, and at the moment, medical dressings are needed to protect the wounds, so that the wounds can be prevented from being infected by dehydration and external environments, a moist environment is provided for the skin repairing process, the growth of new tissues is accelerated, and the healing of the wounds is promoted. Traditional medical dressing that uses cotton gauze and cotton pad as representative, though there is certain liquid absorptivity, simultaneously can also keep apart skin and external world and then protect skin, but easily glue impaired tissue at the wound healing in-process, lead to the dressing induration, it is not good with the skin laminating, and cause the damage to impaired skin once more easily when changing the dressing, be unfavorable for the healing of wound, consequently, it is good to need to develop the moisture absorption gas permeability, can prevent that body fluid from oozing and bacterial infection, the non-adhesion wound, convenient to use's novel functional medical dressing. With the development of science and technology, particularly the adoption of new technology and new technology in the textile industry, a plurality of novel textile fabrics, knitted fabrics and non-woven fabrics appear in the market successively, and the novel textile fabrics, the knitted fabrics and the non-woven fabrics can be used as bed sheets, thermal clothes and the like, thereby creating conditions for improving the life quality of people.

Wujie (reference: Donghua university, 2014) prepares functional medical dressing by taking chitosan fiber, viscose fiber and polyester fiber as raw materials and adopting a spunlace reinforcement technology; the chitosan fiber has good hygroscopicity, but small crimpness, large initial modulus and rigidity, so that the prepared seven different chitosan multilayer spunlace composite functional medical dressings have physical properties such as good flexibility, liquid absorbability, moisture permeability, air permeability and the like, and chemical performance indexes such as the surface foam height of a sample, the amount of dissolved substances in water and the like all accord with medical industry standards, so that the chitosan multilayer spunlace composite functional medical dressings have high liquid absorption rate and air permeability, the surface foam height almost approaches to 0, and the amount of the dissolved substances in water is less than 0.5%. In the prior art, for example, application publication No. CN 1371669A discloses an anti-infection quick-healing composite layer medical dressing, a bed sheet and application thereof; the composite layer medical dressing and sheet is composed of an inner layer of the dressing or sheet, namely a layer contacting human body or animal skin, and an outer layer of the dressing or sheet, wherein the inner layer is composed of an antibacterial far infrared fabric or an antibacterial far infrared non-woven fabric, or the antibacterial deodorant fabric or the antibacterial deodorant non-woven fabric.

Disclosure of Invention

The invention aims to provide an antibacterial fiber cloth with excellent antibacterial and anti-infection properties.

The technical scheme adopted by the invention for realizing the purpose is as follows:

an antibacterial fiber cloth is prepared from 1,3, 7-trihydroxy-2-isopentenyl xanthone modified cellulose nonwoven fabric.

The 1,3, 7-trihydroxy-2-isopentenyl xanthone modified cellulose non-woven fabric is adopted to prepare the antibacterial fiber cloth, so that the antibacterial fiber cloth has better antibacterial and anti-infection performance and better moisture absorption rate and moisture retention rate, when the antibacterial fiber cloth is used in a medical dressing, the antibacterial fiber cloth can keep the wound surface moist when contacting the wound surface, and the mechanical damage caused again when the dressing is replaced is avoided; probably because the 1,3, 7-trihydroxy-2-isopentenyl xanthone is grafted to the surface of the non-woven fabric, the cellulose non-woven fabric has more active groups, and the cellulose non-woven fabric has excellent antibacterial property and better moisture absorption rate and moisture retention rate; in addition, the modified cellulose non-woven fabric has better air permeability and can accelerate the healing of the wound surface better; meanwhile, the cellulose non-woven fabric has better flexibility and better touch feeling when being contacted with a human body; the cellulose non-woven fabric is applied to a medical bed sheet, so that the bed sheet has excellent water washing resistance and long-acting property; therefore, the antibacterial fiber cloth has wide application in the field of medical materials.

Preferably, the preparation method of the antibacterial fiber cloth is as follows:

soaking the cellulose nonwoven fabric in acetone for 2-4 h, performing ultrasonic treatment for 30-50 min, and drying at 100-110 ℃ to obtain cleaned cellulose;

dissolving 0.1-0.2 weight part of ammonium ceric nitrate in 40-60 weight parts of deionized water, adding 0.5-1.5 weight parts of the cellulose non-woven fabric, and then adding 0.12-0.2 weight part of nitric acid as an auxiliary agent to form a system A;

dissolving 0.3-1.2 parts by weight of 1,3, 7-trihydroxy-2-isopentenyl xanthone in 45-60 parts by weight of absolute ethyl alcohol to form a mixed solution B;

adding the mixed solution B into the system A, stirring for 5-10 h at 25-35 ℃, washing and filtering for 3-5 times by using ethanol, washing and filtering for 3-5 times by using deionized water, and drying to constant weight at 70-80 ℃ to obtain the antibacterial fiber cloth.

Preferably, the concentration of the ammonium cerium nitrate is 5 to 6 x 10^-3mol/L, the concentration of nitric acid is 2-3 multiplied by 10^-2The concentration of the 1,3, 7-trihydroxy-2-isopentenyl xanthone is 2-3 × 10^-2mol/L。

The invention also discloses application of the antibacterial fiber cloth in anti-infection composite layer medical dressing and/or bed sheet.

The invention also aims to provide the composite layer medical dressing with excellent antibacterial and anti-infection performance, higher moisture absorption rate and moisture retention rate and better air permeability.

The invention also discloses an anti-infection composite layer medical dressing, which comprises a chitosan fiber layer and an antibacterial fiber layer;

the antibacterial fiber layer is antibacterial fiber cloth.

Preferably, the chitosan fiber layer is an outer layer of the composite layer medical dressing; the antibacterial fiber layer is an inner layer of the composite layer medical dressing and is in contact with the skin of a human body.

The invention adopts the antibacterial fiber cloth as the inner layer of the composite layer medical dressing, namely, the antibacterial fiber cloth is contacted with the skin of a human body, and the chitosan fiber layer is used as the outer layer of the composite layer medical dressing, so that the composite layer medical dressing is obtained; the composite layer medical dressing has excellent antibacterial and anti-infection performance and better moisture absorption rate and moisture retention rate, when the composite layer medical dressing is used in the medical dressing, the composite layer medical dressing can keep the wound surface moist when contacting with the wound surface, and avoids mechanical damage again when the dressing is replaced; meanwhile, the composite layer medical dressing has better air permeability and can accelerate the healing of the wound surface better.

Preferably, the inner layer and the outer layer of the composite medical dressing are fixed by adopting a binding wire.

Still another object of the present invention is to provide an infection-preventing composite bed medical sheet having excellent antibacterial and infection-preventing properties and superior softness, which has a better tactile sensation when being in contact with a human body or an animal, and also has superior wash-resistant properties.

The invention also discloses an anti-infection composite layer medical bed sheet, which comprises a chitosan fiber layer and an antibacterial fiber layer;

the antibacterial fiber layer is antibacterial fiber cloth.

Preferably, the chitosan fiber layer is an outer layer of the composite layer medical bed sheet; the antibacterial fiber layer is a composite layer medical bed sheet inner layer and is in contact with human or animal skin.

The invention adopts antibacterial fiber cloth as the inner layer of the composite layer medical bed sheet, namely, the antibacterial fiber cloth is contacted with the skin of a human body or an animal, and the chitosan fiber layer is used as the outer layer of the composite layer medical bed sheet, so that the composite layer medical bed sheet is obtained; the antibacterial fiber cloth has excellent antibacterial and anti-infection properties, so that the cross infection of the bed sheet can be better prevented; meanwhile, the medical bed sheet has better flexibility, is in contact with human bodies or animals, has better touch feeling and excellent water washing resistance, and can be widely applied to the field of medicine.

Preferably, the peripheries of the inner layer and the outer layer of the anti-infection composite layer medical bed sheet are fixed by adopting binding wires.

The invention also discloses application of the 1,3, 7-trihydroxy-2-isopentenyl xanthone in improving the air permeability of the cellulose non-woven fabric.

The invention also discloses application of the 1,3, 7-trihydroxy-2-isopentenyl xanthone in improving the water washing resistance of the cellulose non-woven fabric.

In order to further improve the antibacterial and anti-infection performance of the composite layer medical dressing, improve the moisture absorption rate and moisture retention rate of the composite layer medical dressing, and simultaneously enable the composite layer medical bed sheet to have excellent flexibility and deodorization performance, the preferable measures further comprise:

soaking the prepared antibacterial fiber cloth in an epicatechin 3-O- (3-O-methyl) gallate solution for reacting for 2-4 h, and drying to obtain a composite layer medical dressing and a bed sheet, so that the composite layer medical dressing and the bed sheet have better antibacterial and anti-infection performance and permeability, and the composite layer medical dressing and the bed sheet have excellent deodorization performance; the reason is probably that the epicatechin 3-O- (3-O-methyl) gallate and active groups in the cellulose non-woven fabric have chemical reaction and play a certain synergistic role to improve the physical and chemical properties of the cellulose non-woven fabric, further improve the antibacterial and anti-infection property of the composite layer medical dressing and the moisture absorption rate and moisture retention rate of the composite layer medical dressing, and simultaneously enable the composite layer medical bed sheet to have excellent softness and deodorization performance and be widely applied to the aspect of medical materials.

The invention adopts 1,3, 7-trihydroxy-2-isopentenyl xanthone modified cellulose non-woven fabric to prepare the antibacterial fiber cloth, thereby having the following beneficial effects: the antibacterial fiber cloth has good antibacterial and anti-infection properties and good moisture absorption rate and moisture retention rate, and when the antibacterial fiber cloth is used in medical dressing, the antibacterial fiber cloth can keep the wound surface moist when contacting with the wound surface, so that the mechanical damage caused by dressing replacement is avoided; probably because the 1,3, 7-trihydroxy-2-isopentenyl xanthone is grafted to the surface of the non-woven fabric, the cellulose non-woven fabric has more active groups, and the cellulose non-woven fabric has excellent antibacterial property and lower permeability; in addition, the modified cellulose non-woven fabric has better air permeability resistance and can accelerate the healing of the wound surface better; meanwhile, the cellulose non-woven fabric has better flexibility and better touch feeling when being contacted with a human body; the cellulose non-woven fabric is applied to a medical bed sheet, so that the bed sheet has excellent water washing resistance and long-acting property; therefore, the antibacterial fiber cloth has wide application in the field of medical materials.

The chitosan fiber layer is used as the outer layer of the composite layer medical dressing, the antibacterial fiber layer is used as the inner layer of the composite layer medical dressing and is contacted with the skin of a human body, so that the composite layer medical dressing is prepared, and the composite layer medical dressing has the following beneficial effects: the composite layer medical dressing has excellent antibacterial and anti-infection properties and better moisture absorption rate and moisture retention rate, and when the composite layer medical dressing is used in the medical dressing, the composite layer medical dressing can keep the wound surface moist when contacting with the wound surface, so that the mechanical damage caused again when the dressing is replaced is avoided; meanwhile, the composite layer medical dressing has better air permeability and can accelerate the healing of the wound surface better.

The invention takes the chitosan fiber layer as the outer layer of the composite layer medical bed sheet, and the antibacterial fiber layer as the inner layer of the composite layer medical bed sheet, which is contacted with the skin of human body or animal, thereby preparing the composite layer medical bed sheet, and the invention has the following beneficial effects: the antibacterial fiber cloth has excellent antibacterial and anti-infection properties, so that the cross infection of the composite layer medical bed sheet can be better prevented; meanwhile, the medical bed sheet has better flexibility, is in contact with human bodies or animals, has better touch feeling, has excellent water washing resistance and long-acting property, and can be widely applied to the field of medicine.

Therefore, the antibacterial fiber cloth with excellent antibacterial and anti-infection properties is used as the inner layer of the composite layer medical dressing, so that the composite layer medical dressing has excellent antibacterial and anti-infection properties and better moisture absorption rate and moisture retention rate, and meanwhile, the composite layer medical dressing has better air permeability; in addition, the composite bed sheet is used as the inner layer of the composite bed sheet, so that the composite bed sheet has excellent antibacterial and anti-infection performance, flexibility, better water washing resistance and long-acting performance, and excellent deodorization performance.

Drawings

FIG. 1 is an infrared spectrum of a cellulose nonwoven fabric in example 2 before and after modification;

FIG. 2 shows the bacteriostatic rate of the infection-preventing composite layer medical dressing;

FIG. 3 shows the fluid absorption rate and the fluid retention rate of the infection-preventing composite layer medical dressing;

FIG. 4 is the air permeability of the infection-preventing composite layer medical dressing;

fig. 5 shows the bending length of the infection-preventing composite bed sheet.

Detailed Description

The technical solution of the present invention is further described in detail below with reference to the following detailed description and the accompanying drawings:

example 1

A preparation method of antibacterial fiber cloth comprises the following steps:

soaking cellulose in acetone for 3h, performing ultrasonic treatment for 35min, and drying at 105 deg.C to obtain cleaned cellulose;

0.13 part by weight of a catalyst with a concentration of 5.2X 10^-3mol/L ammonium ceric nitrate was dissolved in 55 parts by weight of deionized water, 0.9 part by weight of the above cellulose nonwoven fabric was added, and 0.17 part by weight of a 2.5X 10-concentrated solution was added^-2Forming a system A by using mol/L nitric acid as an auxiliary agent;

0.8 part by weight of a catalyst with a concentration of 2.2X 10^-2Dissolving 1,3, 7-trihydroxy-2-isopentenyl xanthone in 50 parts by weight of absolute ethyl alcohol to form a mixed solution B;

adding the mixed solution B into the system A, stirring for 8h at 30 ℃, washing and filtering for 3 times by using ethanol, washing and filtering for 3 times by using deionized water, and drying to constant weight at 75 ℃ to obtain the antibacterial fiber cloth.

Example 2

soaking the cellulose nonwoven fabric in acetone for 4h, performing ultrasonic treatment for 30min, and drying at 110 deg.C to obtain cleaned cellulose;

0.2 part by weight of a catalyst with a concentration of 5.6X 10^-3mol/L ammonium ceric nitrate was dissolved in 60 parts by weight of deionized water, 1.5 parts by weight of the above cellulose nonwoven fabric was added, and 0.2 part by weight of a 2.5X 10 solution having a concentration of^-2Forming a system A by using mol/L nitric acid as an auxiliary agent;

1.2 parts by weight of a catalyst with a concentration of 3X 10^-2Dissolving 1,3, 7-trihydroxy-2-isopentenyl xanthone in 50 parts by weight of absolute ethyl alcohol to form a mixed solution B;

adding the mixed solution B into the system A, stirring for 8h at 30 ℃, washing and filtering for 3 times by using ethanol, washing and filtering for 5 times by using deionized water, and drying to constant weight at 75 ℃ to obtain the antibacterial fiber cloth.

Example 3

the antibacterial fiber cloth prepared in the example 1 is soaked in epicatechin 3-O- (3-O-methyl) gallate solution for reaction for 3 hours, and is dried at the temperature of 75 ℃ to constant weight, so that the antibacterial fiber cloth is obtained.

Example 4

An anti-infection composite layer medical dressing takes a chitosan fiber layer as an outer layer of the medical dressing, and takes the antibacterial fiber cloth in example 1 as an inner layer of the dressing, and the antibacterial fiber cloth is in contact with a human body; and cutting the outer layer and the inner layer of the dressing into the same size, and fixing by adopting a binding wire to obtain the composite layer medical dressing.

Example 5

An anti-infection composite layer medical dressing takes a chitosan fiber layer as an outer layer of the medical dressing, and takes the antibacterial fiber cloth in example 2 as an inner layer of the dressing, and the antibacterial fiber cloth is in contact with a human body; cutting the outer layer and the inner layer of the dressing into the same size, and fixing by adopting a binding wire to obtain the composite layer medical dressing.

Example 6

An anti-infection composite layer medical dressing takes a chitosan fiber layer as an outer layer of the medical dressing, and takes the antibacterial fiber cloth in example 3 as an inner layer of the dressing, and the antibacterial fiber cloth is in contact with a human body; and cutting the outer layer and the inner layer of the dressing into the same size, and fixing by adopting a binding wire to obtain the composite layer medical dressing.

Example 7

An anti-infection composite layer medical bed sheet, which takes a chitosan fiber layer as an outer layer of the medical bed sheet, takes the antibacterial fiber cloth in example 1 as an inner layer of the bed sheet, and is contacted with the skin of a human body or an animal; cutting the outer layer and the inner layer of the bed sheet into the same size, and fixing the peripheries of the inner layer and the outer layer of the medical bed sheet by adopting binding wires to obtain the composite layer medical bed sheet.

Example 8

An anti-infection composite layer medical bed sheet, which takes a chitosan fiber layer as an outer layer of the medical bed sheet, takes the antibacterial fiber cloth in example 2 as an inner layer of the bed sheet, and is contacted with the skin of a human body or an animal; cutting the outer layer and the inner layer of the bed sheet into the same size, and fixing the peripheries of the inner layer and the outer layer of the medical bed sheet by adopting binding wires to obtain the composite layer medical bed sheet.

Example 9

An anti-infection composite layer medical bed sheet, which takes a chitosan fiber layer as an outer layer of the medical bed sheet, takes the antibacterial fiber cloth in example 3 as an inner layer of the bed sheet, and is contacted with the skin of a human body or an animal; cutting the outer layer and the inner layer of the bed sheet into the same size, and fixing the peripheries of the inner layer and the outer layer of the medical bed sheet by adopting binding wires to obtain the composite layer medical bed sheet.

Comparative example 1

A method for preparing an antibacterial fiber cloth, the other steps are the same as the example 1, except that the 1,3, 7-trihydroxy-2-isopentenyl xanthone is replaced by 2-methacrylamide in the mixed solution B, which is different from the example 1.

Comparative example 2

An anti-infection composite layer medical dressing takes a chitosan fiber layer as an outer layer of the medical dressing, takes an antibacterial fiber cloth in a comparative example 1 as an inner layer of the dressing, and is contacted with a human body; cutting the outer layer and the inner layer of the dressing into the same size, and fixing by adopting a binding wire to obtain the composite layer medical dressing.

Comparative example 3

An anti-infection composite layer medical bed sheet, which takes a chitosan fiber layer as the outer layer of the medical bed sheet and takes the antibacterial fiber cloth in the comparative example 1 as the inner layer of the bed sheet, and is contacted with the skin of a human body or an animal; cutting the outer layer and the inner layer of the bed sheet into the same size, and fixing the peripheries of the inner layer and the outer layer of the medical bed sheet by adopting binding wires to obtain the composite layer medical bed sheet.

Test example 1

1. Determination of antibacterial fiber cloth infrared spectrogram

Structural analysis of the cellulose nonwoven fabric before and after modification was carried out by Fourier transform infrared spectrometer (Nicolet-6700, Thermo Fisher Scientific Co., Ltd., the Netherlands) with scanning range of 4000-^-1。

FIG. 1 shows the IR spectra before and after modification of the nonwoven cellulose fabric in example 2. As can be seen from fig. 1, the cellulose nonwoven fabric before modification is different from the cellulose nonwoven fabric after modification in that: the infrared spectrum of the modified cellulose non-woven fabric, namely the infrared spectrum of the antibacterial fiber cloth, is 3647.7cm^-1、1386.2cm^-1Wide and strong characteristic absorption peaks appear nearby and are respectively stretching vibration of phenolic hydroxyl and benzene rings; at 2889.4cm^-1、1147.6cm^-1The characteristic absorption peaks appearing nearby are respectively the stretching vibration of C-H and C-C in methyl and methylene; 1693.8cm^-1The strong characteristic absorption peak appearing nearby is the stretching vibration of the aromatic ketone; at 1242.5cm^-1、1036.3cm^-1Stretching vibration of aromatic ether bonds at characteristic absorption peaks appearing nearby; from this, it was found that the antibacterial fiber cloth was obtained by modifying the cellulose nonwoven fabric with 1,3, 7-trihydroxy-2-isopentenyl xanthone.

Test example 2

1. Determination of antibacterial and anti-infection property of anti-infection composite layer medical dressing

The test tests the antibacterial rate of the dressing sample on escherichia coli and staphylococcus aureus according to GB/T209443 'evaluation of textile antibacterial performance'.

Fig. 2 shows the bacteriostasis rate of the infection-preventing composite layer medical dressing. As can be seen from fig. 2, the bacteriostatic rates of the traditional Chinese medical dressings in examples 4-5 for staphylococcus aureus are higher than 99%, the bacteriostatic rate for escherichia coli is higher than 98.5%, the bacteriostatic rates for staphylococcus aureus and escherichia coli in comparative examples 4 and 2 are higher than that in comparative example 2, which shows that the antibacterial fiber cloth is obtained by modifying the cellulose non-woven fabric with 1,3, 7-trihydroxy-2-isopentenyl xanthone, and the bacteriostatic rates of the composite layer medical dressing for escherichia coli and staphylococcus aureus are improved, i.e. the composite layer medical dressing has excellent anti-infection performance; comparing example 4 with example 6, the bacteriostatic rates of staphylococcus aureus and escherichia coli in example 6 are higher than those in example 4, which shows that the antibacterial fiber cloth is modified by epicatechin 3-O- (3-O-methyl) gallate, so that the bacteriostatic rate of the infection-preventing composite layer medical dressing on staphylococcus aureus and escherichia coli is further improved, and the composite layer medical dressing has better anti-infection performance.

2. Determination of hygroscopicity and moisture retention of anti-infection composite layer medical dressing

In the test, a test sample is cut into a size of 20mm multiplied by 20mm, alginate non-woven fabric is used as a control group, the test sample is placed in a centrifuge tube filled with test solution to be soaked for 5-10 min, the test sample is taken out and weighed, the test sample is placed in the centrifuge tube filled with a stainless steel net and is placed in a centrifuge 800r/min for spin-drying, the test sample is taken out and weighed for 5min, and the calculation formula is as follows:

liquid absorption rate (%) - (weight after liquid absorption (g) -weight before liquid absorption (g))/weight before liquid absorption (g) × 100%

Retention rate (%) - (weight after centrifugation (g) -weight before liquid absorption (g))/weight before liquid absorption (g) × 100%

Fig. 3 shows the liquid absorption rate and the liquid retention rate of the infection-preventing composite layer medical dressing. As can be seen from fig. 3, the liquid absorption rate and the liquid retention rate of examples 4 to 5 are higher than 2105% and 881%, compared example 4 and comparative example 2, and the liquid absorption rate and the liquid retention rate of example 4 are much higher than comparative example 2, which shows that the antibacterial fiber cloth is obtained by modifying the cellulose non-woven fabric with 1,3, 7-trihydroxy-2-isopentenyl xanthone, and the liquid absorption rate and the liquid retention rate of the infection-preventing composite layer medical dressing are significantly improved; comparing example 4 with example 6, the liquid absorption rate and the liquid retention rate of example 6 are higher than those of example 4, which shows that the liquid absorption rate and the liquid retention rate of the infection-preventing composite layer medical dressing are improved by further modifying the antibacterial fiber cloth with epicatechin 3-O- (3-O-methyl) gallate; comparing examples 4-6, comparative example 2 and a control group, the liquid absorption rate and the liquid retention rate of examples 4-6 and comparative example 2 are higher than those of the control group, which shows that the infection-preventing composite layer medical dressing prepared by the technical scheme is obviously superior to a commercial dressing.

3. Determination of air permeability of anti-infection composite layer medical dressing

The determination of the air permeability of the test sample refers to GB/T5453-1997, and the air permeability test is carried out on different sample medical dressings. The sample specification was 5cm × 5cm, and the nozzle size was selected

The breathability of the dressing was tested using a YG461E computer breathability tester.

Fig. 4 is the air permeability of the infection-preventing composite layer medical dressing. As can be seen from FIG. 4, the air permeability of examples 4-5 is higher than 2155mm/s, the air permeability of comparative example 4 and comparative example 2 is higher than that of comparative example 2, which shows that the air permeability of the infection-preventing composite layer medical dressing is improved by modifying the cellulose non-woven fabric with 1,3, 7-trihydroxy-2-isopentenyl xanthone to obtain the antibacterial fiber cloth which is used as the inner layer of the infection-preventing composite layer medical dressing; comparing example 4 with example 6, there was little difference and a slight increase in the air permeability of example 6 with example 4, which shows that the use of epicatechin 3-O- (3-O-methyl) gallate for modifying the antibacterial fiber cloth has no significant effect on the air permeability of the infection-preventing composite layer medical dressing.

Test example 3

1. Determination of softness of anti-infection composite layer medical bed sheet

The test is carried out by adopting an LLY type electronic stiffness instrument according to GB/T18318-2001; the specification of the sample is 3cm multiplied by 3cm, and the warp direction and the weft direction of the square sample are respectively three; the narrow sample is placed on a measuring plane of an instrument, a sliding plate covers the upper portion of the sample, the sliding plate with a rubber layer attached to the lower plane drives the sample to move leftwards, one end of the sample is gradually separated from the plane and supported into a cantilever shape, when the sample bends downwards to 41.5 degrees under the action of self weight, a light path is cut off, and the length of the sample extending out of a supporting surface is the sliding-out length L. The bending length is L/2, the greater the bending length, the stiffer the fabric. Therefore, the bending strength is also called stiffness, which is expressed in cm, and the general medical bed sheet is used as a control group.

Fig. 5 shows the bending length of the infection-preventing composite bed sheet. As can be seen from FIG. 5, the bending length of examples 7-8 is not higher than 2.5cm, the bending length of comparative example 7 and comparative example 3 is lower than that of comparative example 3, which shows that the bending length of the medical bed sheet is reduced by modifying the cellulose non-woven fabric with 1,3, 7-trihydroxy-2-isopentenyl xanthone to obtain the antibacterial fiber cloth, i.e., the flexibility of the anti-infection composite bed sheet is improved, so that the anti-infection composite bed sheet has better touch feeling; comparing example 7 with example 9, the bending length of example 9 is lower than that of example 7, which shows that the bending length of the anti-infection composite layer medical bed sheet is further reduced by modifying the antibacterial fiber cloth with epicatechin 3-O- (3-O-methyl) gallate, so that the anti-infection composite layer medical bed sheet has better softness.

2. Determination of water washing resistance of anti-infection composite layer medical bed sheet

Placing 1g of sample in a funnel padded with three layers of microfiltration membranes, adding 300mL of deionized water, stirring for 1min by using a glass rod, then slowly performing suction filtration by using a vacuum pump, performing suction filtration for the next time after no water drops, performing suction filtration for about 8min each time, and repeating for 50 times; reference "test example 2: the determination of the antibacterial and anti-infection performance of the anti-infection composite layer medical dressing tests the antibacterial rate of the anti-infection composite layer medical bed sheet.

TABLE 1 determination of Water resistance of infection-preventing composite layer medical bed sheet

As can be seen from table 1, after 50 times of water washing, the bacteriostatic rate of the infection-preventing composite layer medical bed sheet of examples 7 to 8 on staphylococcus aureus is still higher than 99.5%, and the bacteriostatic rate of escherichia coli is still higher than 99%, and before and after water washing, the bacteriostatic rate of the infection-preventing composite layer medical bed sheet on staphylococcus aureus and escherichia coli is almost not reduced; the bacteriostasis rates of staphylococcus aureus and escherichia coli in the comparative example 2 are reduced to a certain extent; comparing example 7 with comparative example 3, it can be seen that the water washing resistance of example 7 is better than that of comparative example 3, which shows that 1,3, 7-trihydroxy-2-isopentenyl xanthone is adopted to modify the cellulose non-woven fabric to obtain the antibacterial fiber cloth, so that the water washing resistance of the infection-preventing composite layer medical bed sheet is improved, and the infection-preventing composite layer medical bed sheet has long-acting antibacterial performance; comparing example 7 with example 9, after 50 times of water washing, the bacteriostasis rates of staphylococcus aureus and escherichia coli in example 9 are not obviously reduced, which shows that the water resistance of the infection-preventing composite layer medical bed sheet is hardly influenced negatively by further modifying the antibacterial fiber cloth with the epicatechin 3-O- (3-O-methyl) gallate.

3. Determination of deodorization performance of anti-infection composite layer medical bed sheet

The test tests the effect of the medical bedsheet on eliminating ammonia gas according to the standard SEK mark fiber product certification standard of applying deodorization processing identification certification to textile products by the Japan fiber evaluation technology Association; the bed sheet obtained from the common viscose fiber was used as a control group.

TABLE 2 Elimination test results of single pair of ammonia gas of anti-infection composite layer medical bed

Test group	Initial concentration/(mg/L)	Final concentration/(mg/L)	Elimination rate/%)
				Control group	93	85	8.6
Example 7	93	1.9	98
				Example 8	93	2.3	97.5
Example 9	93	1.5	98.3
				Comparative example 3	93	57	38.7

As can be seen from table 2, the ammonia gas elimination rate of examples 7 to 8 is not lower than 97.5%, the ammonia gas elimination rate of the composite layer medical bed sheet in comparative example 7 and the control group and comparative example 3 is much higher than that of the composite layer medical bed sheet in comparative example 7 and comparative example 2, which shows that the antibacterial fiber cloth is obtained by modifying the cellulose non-woven fabric with 1,3, 7-trihydroxy-2-isopentenyl xanthone, the composite layer medical bed sheet is prepared, the ammonia gas elimination effect of the medical bed sheet is remarkably improved, and the composite layer medical bed sheet has an excellent deodorization effect; comparing example 7 with example 9, the ammonia gas elimination rate of the composite layer medical sheet in example 9 is slightly higher than that of example 7, which shows that the elimination effect of the composite layer medical sheet on ammonia gas is further improved by modifying the antibacterial fiber cloth with epicatechin 3-O- (3-O-methyl) gallate.

Conventional operations in the operation steps of the present invention are well known to those skilled in the art and will not be described herein.

The above embodiments are merely illustrative, and not restrictive, and those skilled in the art can make various changes and modifications without departing from the spirit and scope of the invention. Therefore, all equivalent technical solutions also belong to the scope of the present invention, and the protection scope of the present invention should be defined by the claims.

Claims

1. An antibacterial fiber cloth is characterized in that: the antibacterial fiber cloth is prepared from 1,3, 7-trihydroxy-2-isopentenyl xanthone modified cellulose non-woven fabric.

2. Use of an antibacterial fiber cloth according to claim 1 in an anti-infection composite layer medical dressing and/or a bed sheet.

3. An anti-infection composite layer medical dressing is characterized in that: the medical dressing of the anti-infection composite layer comprises a chitosan fiber layer and an antibacterial fiber layer;

the antibacterial fiber layer is the antibacterial fiber cloth of claim 1.

4. The infection-preventing composite medical dressing of claim 3, wherein: the chitosan fiber layer is an outer layer of the composite layer medical dressing; the antibacterial fiber layer is an inner layer of the composite layer medical dressing and is in contact with the skin of a human body.

5. The infection-preventing composite medical dressing of claim 4, wherein: the inner layer and the outer layer of the composite layer medical dressing are fixed by adopting a binding wire.

6. An anti-infection composite layer medical bed sheet is characterized in that: the anti-infection composite layer medical bed sheet comprises a chitosan fiber layer and an antibacterial fiber layer;

the antibacterial fiber layer is the antibacterial fiber cloth of claim 1.

7. The anti-infection composite layer medical bed sheet as claimed in claim 6, wherein: the chitosan fiber layer is an outer layer of the composite layer medical bed sheet; the antibacterial fiber layer is a composite layer medical bed sheet inner layer and is in contact with human or animal skin.

8. The anti-infection composite layer medical bed sheet as claimed in claim 7, wherein: the peripheries of the inner layer and the outer layer of the anti-infection composite layer medical bed sheet are fixed by adopting binding wires.

Use of 1,3, 7-trihydroxy-2-isopentenyl xanthone in improving air permeability of cellulose nonwoven fabric is provided.

Use of 1,3, 7-trihydroxy-2-isopentenyl xanthone in improving water washing resistance of cellulose nonwoven fabric.