CN111346255B - Wound dressing with antibacterial and bacteria-carrying warning functions and preparation method thereof - Google Patents
Wound dressing with antibacterial and bacteria-carrying warning functions and preparation method thereof Download PDFInfo
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- CN111346255B CN111346255B CN202010321217.8A CN202010321217A CN111346255B CN 111346255 B CN111346255 B CN 111346255B CN 202010321217 A CN202010321217 A CN 202010321217A CN 111346255 B CN111346255 B CN 111346255B
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- polyvinyl alcohol
- moisture absorption
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- 229960000907 methylthioninium chloride Drugs 0.000 claims abstract description 24
- 239000011241 protective layer Substances 0.000 claims abstract description 24
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 21
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- 238000001035 drying Methods 0.000 claims abstract description 6
- 150000004714 phosphonium salts Chemical group 0.000 claims abstract description 6
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- ZTQSAGDEMFDKMZ-UHFFFAOYSA-N Butyraldehyde Chemical compound CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 claims description 36
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- 229910021641 deionized water Inorganic materials 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
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- 238000000034 method Methods 0.000 claims description 9
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- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 16
- 239000000243 solution Substances 0.000 description 14
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- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical group [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- NSIFOGPAKNSGNW-UHFFFAOYSA-M dodecyl(triphenyl)phosphonium bromide Chemical group [Br-].C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(CCCCCCCCCCCC)C1=CC=CC=C1 NSIFOGPAKNSGNW-UHFFFAOYSA-M 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 3
- 206010072170 Skin wound Diseases 0.000 description 3
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- 239000000661 sodium alginate Substances 0.000 description 3
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- SXPWTBGAZSPLHA-UHFFFAOYSA-M cetalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SXPWTBGAZSPLHA-UHFFFAOYSA-M 0.000 description 1
- 229960000228 cetalkonium chloride Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
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- 238000003113 dilution method Methods 0.000 description 1
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- UXMZNEHSMYESLH-UHFFFAOYSA-M hexadecyl(triphenyl)phosphanium;bromide Chemical compound [Br-].C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(CCCCCCCCCCCCCCCC)C1=CC=CC=C1 UXMZNEHSMYESLH-UHFFFAOYSA-M 0.000 description 1
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- 238000011068 loading method Methods 0.000 description 1
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- FUMBGFNGBMYHGH-UHFFFAOYSA-M triphenyl(tetradecyl)phosphanium;bromide Chemical compound [Br-].C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(CCCCCCCCCCCCCC)C1=CC=CC=C1 FUMBGFNGBMYHGH-UHFFFAOYSA-M 0.000 description 1
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Images
Classifications
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- A61L15/42—Use of materials characterised by their function or physical properties
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Abstract
The wound dressing with the antibacterial and bacteria warning functions comprises a wound contact layer, an intermediate moisture absorption layer and an external protective layer, wherein the wound contact layer is a fiber film with a blood coagulation function, the intermediate moisture absorption layer is polyvinyl alcohol porous foam containing methylene blue and an antibacterial agent, the external protective layer is polyvinyl alcohol dense foam containing methylene blue and the antibacterial agent, the intermediate moisture absorption layer and the external protective layer are of an integrated structure, the wound contact layer and the intermediate moisture absorption layer are combined together, and the antibacterial agent is quaternary ammonium salt or quaternary phosphonium salt. When the dressing of the invention is not germ-carrying, the middle moisture absorption layer and the outer protective layer are blue, and if bacteria grow, the color of the middle moisture absorption layer and the outer protective layer gradually changes from blue to white. The preparation method of the dressing comprises the following steps: (1) preparing a polyvinyl alcohol foam body with a compact top surface and a porous structure at the lower part, (2) soaking and drying, (3) preparing a fiber film with a blood coagulation function, and (4) cutting, combining, packaging and sterilizing.
Description
Technical Field
The invention belongs to the field of wound dressings, and relates to a wound dressing with antibacterial and bacteria warning functions and a preparation method thereof.
Background
Skin wounds are a common type of injury, and the dressing is a medical material for treating and protecting the skin wounds. There are a number of wound dressings available on the market today, but mainly two types. One type is a dressing with the functions of blood coagulation, moisture absorption and wound healing promotion, and the other type is a dressing with an antibacterial function added on the basis of the functions, but the dressing with the antibacterial function mainly endows the dressing with good antibacterial performance by adding silver ions (such as Aquacel Ag dressing produced by Convatec), the silver ions have certain cytotoxicity and can cause adverse effects on a wounded person, and the preparation cost of the dressing can be increased by adding the silver ions.
Because the recovery of skin wound needs a certain time, therefore dressing need change in the use, the purpose of change is the needs of medicine application, prevents to lead to the wound infection because of dressing area fungus. If the dressing is sterile, the dressing should be replaced, even if administration is not required, or the time for wound healing may be extended, and other complications may even arise from bacterial infection. Therefore, it is an important issue to determine whether the dressing is sterile. Bahram Mirani et al discloses a wound dressing with antibacterial and bacteria-carrying warning functions and a preparation method thereof (Bahram Mirani et al. adv. healthcare mater.2017,6,1700718.) the dressing contains pH-sensitive dye mesoporous resin beads by utilizing the mechanism that bacteria are propagated to enable the environment to present acidity, whether the dressing carries bacteria is judged through the change of the color of the dressing, and the dressing has the antibacterial function through adding silver ions. Although the dressing is convenient to judge whether the dressing carries bacteria or not, the dressing is prepared by taking hydrogel as a matrix and covering a layer of porous sensor array prepared by a 3D printing technology on the surface of the hydrogel, the porous sensor array is composed of color-changing alginate fibers, the dressing is changed in color by the pH sensitive dye mesoporous resin beads doped in the color-changing alginate fibers, and silver ions are used as an antibacterial agent, so that the preparation process is complex, the production cost is high, and side effects generated by the silver ions exist.
Disclosure of Invention
The invention aims to overcome the defects of the prior art, provides a novel wound dressing with antibacterial and bacteria-carrying warning functions and a preparation method thereof, simplifies the preparation process, reduces the production cost and avoids the side effect of silver ions on the premise of ensuring the blood coagulation, moisture absorption, antibacterial and bacteria-carrying warning effects.
The wound dressing with the antibacterial and bacteria warning functions comprises a wound contact layer, an intermediate moisture absorption layer and an outer protective layer, wherein the wound contact layer is a fiber film with a blood coagulation function, the intermediate moisture absorption layer is polyvinyl alcohol porous foam containing methylene blue and an antibacterial agent, the outer protective layer is polyvinyl alcohol dense foam containing methylene blue and the antibacterial agent, the intermediate moisture absorption layer and the outer protective layer are of an integrated structure, and the wound contact layer and the intermediate moisture absorption layer are combined together.
The wound dressing with the antibacterial and bacteria warning functions is characterized in that the antibacterial agent is quaternary ammonium salt or quaternary phosphonium salt.
According to the wound dressing with the antibacterial and bacteria warning functions, the intermediate moisture absorption layer and the outer protective layer contain methylene blue which is a bacterial tissue coloring agent, when the dressing does not contain bacteria, the intermediate moisture absorption layer and the outer protective layer are blue, and if bacteria grow, the color of the intermediate moisture absorption layer and the outer protective layer is gradually changed from blue to the natural color (white) of polyvinyl alcohol foam.
The invention relates to a preparation method of a wound dressing with antibacterial and bacteria warning functions, which comprises the following steps:
(1) preparing the polyvinyl alcohol foam with compact top surface and porous lower part
Dissolving polyvinyl alcohol in deionized water at 85-120 ℃, cooling to room temperature, adding formaldehyde or butyraldehyde and a catalyst concentrated sulfuric acid, uniformly mixing to form a reaction liquid, heating the reaction liquid to 80-90 ℃, and preserving heat for 1-2 hours to obtain a polyvinyl alcohol foam body with a compact top surface and a porous structure at the lower part;
(2) soaking and drying
Washing the polyvinyl alcohol foam obtained in the step (1) with deionized water to remove unreacted formaldehyde or butyraldehyde and a catalyst concentrated sulfuric acid, then placing the polyvinyl alcohol foam into a soaking solution composed of methylene blue, an antibacterial agent and deionized water, soaking at room temperature for at least 1 hour, taking out the polyvinyl alcohol foam from the soaking solution after soaking is finished, and carrying out freeze vacuum drying to obtain an intermediate moisture absorption layer and an external protective layer which are of an integrated structure and contain the methylene blue and the antibacterial agent;
(3) preparation of fibrous membrane with blood coagulation function
Preparing a fiber film with a blood coagulation function by adopting an electrostatic spinning method, wherein the electrostatic spinning raw material is one of alginate, chitosan and collagen, or sodium carboxymethylcellulose and polyvinyl alcohol;
(4) cutting, combining, packaging and sterilizing
And (3) cutting the integrated middle moisture absorption layer and the external protective layer obtained in the step (2) and the fiber film obtained in the step (3) into required sizes according to specification requirements, coating ethanol on the fiber film and the middle moisture absorption layer, attaching, packaging and sterilizing to obtain the wound dressing with antibacterial and antibacterial warning functions.
The preparation method of the wound dressing with the antibacterial and bacteria warning functions comprises the following steps of (1) enabling the concentration of polyvinyl alcohol in a reaction solution to be 50-100 g/L; the ratio of the mass of the polyvinyl alcohol to the volume of the formaldehyde or the butyraldehyde is 1 (0.5-1), wherein the mass unit of the polyvinyl alcohol is g, the volume unit of the formaldehyde or the butyraldehyde is mL, or the mass unit of the polyvinyl alcohol is kg, and the volume unit of the formaldehyde or the butyraldehyde is L; the ratio of the mass of the polyvinyl alcohol to the volume of the concentrated sulfuric acid catalyst is 1: (0.04-0.15), wherein the mass unit of the polyvinyl alcohol is g, and the volume unit of the concentrated sulfuric acid is mL, or the mass unit of the polyvinyl alcohol is kg, and the volume unit of the concentrated sulfuric acid is L.
According to the preparation method of the wound dressing with the antibacterial and bacteria warning functions, in the soak solution in the step (2), the concentration of methylene blue is 0.5-5 g/L, and the concentration of an antibacterial agent is 0.04-0.10 g/L.
The preparation method of the wound dressing with the antibacterial and antibacterial warning functions comprises the steps of (3) preparing electrostatic spinning slurry from electrostatic spinning raw materials and deionized water, wherein the concentration of the electrostatic spinning raw materials in the slurry is 50-150 g/L; when the electrostatic spinning raw materials are sodium carboxymethyl cellulose and polyvinyl alcohol, the mass ratio of the sodium carboxymethyl cellulose to the polyvinyl alcohol is 1: (2-3).
According to the preparation method of the wound dressing with the antibacterial and bacteria warning functions, the antibacterial agent in the soaking solution in the step (2) is quaternary ammonium salt or quaternary phosphonium salt. The quaternary ammonium salt is preferably octadecyl trimethyl ammonium chloride, hexadecyl trimethyl ammonium bromide or hexadecyl dimethyl benzyl ammonium chloride, and the quaternary phosphonium salt is preferably dodecyl triphenyl phosphonium bromide, tetradecyl triphenyl phosphonium bromide or hexadecyl triphenyl phosphonium bromide.
Compared with the prior art, the invention has the following beneficial effects: cetyl trimethyl ammonium Bromide
1. The wound contact layer of the wound dressing is a fiber film with a blood coagulation function, the middle moisture absorption layer is polyvinyl alcohol porous foam containing methylene blue and an antibacterial agent, the outer protection layer is polyvinyl alcohol compact foam containing methylene blue and an antibacterial agent, so that the wound dressing has excellent blood coagulation and moisture absorption performances, and has antibacterial and bacteria-carrying warning functions, and a wounded and medical personnel can judge whether the wound dressing carries bacteria and the bacteria-carrying degree through the color changes of the outer protection layer and the middle moisture absorption layer of the dressing and replace the wound dressing in time.
2. Because the antibacterial agent in the wound dressing is quaternary ammonium salt or quaternary phosphonium salt, the antibacterial agent has the characteristics of high efficiency, low toxicity, difficult influence from pH value change, convenient use, stronger stripping effect on a mucus layer, stable chemical property, better dispersion and corrosion inhibition effect and the like, thereby not only endowing the dressing with excellent bactericidal performance, but also overcoming the adverse effect of silver ions on a wounded person.
3. The raw materials and equipment of the method can be purchased in the market, and the method has simple process steps and low energy consumption, thereby being easy to popularize and carrying out industrial mass production.
Drawings
FIG. 1 is a schematic view of the wound dressing with antibacterial and bacteria warning functions, in which the middle moisture absorption layer and the outer protective layer are separated from the wound contact layer;
FIG. 2 is a schematic view of the combination of an intermediate moisture-absorbing layer and an outer protective layer with a wound contact layer in an integrated structure in the wound dressing with antibacterial and bacteria warning functions according to the present invention;
fig. 3 is a scanning electron micrograph of the wound contact layer prepared in example 1.
In the figure, 1 is an outer protective layer, 2 is an intermediate moisture-absorbing layer, and 3 is a wound contact layer.
Detailed Description
The wound dressing with antibacterial and bacteria warning functions and the preparation method thereof are further described by the following embodiments and the accompanying drawings.
In the following examples, the model of the electrospinning apparatus was SS-2535 (Beijing Yongkang Leye science and technology development Co., Ltd.), and the plasma sterilizer was a Diener Electronic plasma sterilizer in Germany. All the raw materials are purchased from the market.
Example 1
The steps of this example are as follows:
(1) preparing the polyvinyl alcohol foam with compact top surface and porous lower part
Dissolving polyvinyl alcohol in deionized water at 90 ℃, cooling to room temperature, adding formaldehyde and concentrated sulfuric acid, uniformly mixing to form a reaction liquid, heating the reaction liquid in an oven to 80 ℃, and keeping the temperature for 2 hours to obtain a polyvinyl alcohol foam body with a compact top surface and a porous structure at the lower part, wherein in the reaction liquid, the concentration of the polyvinyl alcohol is 80g/L, the ratio of the mass of the polyvinyl alcohol to the volume of the formaldehyde is 1:0.6, the ratio of the mass of the polyvinyl alcohol to the volume of the concentrated sulfuric acid is 1:0.13, the mass unit of the polyvinyl alcohol is g, and the volume units of the formaldehyde and the concentrated sulfuric acid are mL;
(2) soaking and drying
Repeatedly cleaning the polyvinyl alcohol foam obtained in the step (1) with deionized water, removing unreacted formaldehyde and concentrated sulfuric acid, then placing the cleaned polyvinyl alcohol foam into a soaking solution composed of methylene blue, octadecyl trimethyl ammonium chloride and deionized water, soaking at room temperature for 1.2h, taking out the polyvinyl alcohol foam from the soaking solution after soaking, and carrying out freeze vacuum drying at-20 ℃ to remove the contained deionized water, thus obtaining an intermediate moisture absorption layer and an external protective layer which contain the methylene blue and octadecyl trimethyl ammonium chloride and have an integrated structure, wherein in the soaking solution, the concentration of the methylene blue is 0.5g/L, and the concentration of the octadecyl trimethyl ammonium chloride is 0.1 g/L;
(3) preparation of fibrous membrane with blood coagulation function
Preparing a fiber film with a blood coagulation function by adopting an electrostatic spinning method, wherein the electrostatic spinning raw materials comprise sodium carboxymethylcellulose and polyvinyl alcohol, the mass ratio of the sodium carboxymethylcellulose to the polyvinyl alcohol is 1:2, the sodium carboxymethylcellulose and the polyvinyl alcohol are dissolved in deionized water to prepare electrostatic spinning slurry, the concentration of the sodium carboxymethylcellulose and the polyvinyl alcohol in the slurry is 150g/L, the slurry is filled into an injector of electrostatic spinning equipment, the distance between the needle point of the injector and a receiver of the electrostatic spinning equipment is controlled to be 10cm, and the electrostatic spinning equipment is started to work to prepare the fiber film with the blood coagulation function (the scanning electron microscope picture of the fiber film is shown in figure 3);
(4) cutting, combining, packaging and sterilizing
And (3) cutting the integrated middle moisture absorption layer and the external protective layer obtained in the step (2) and the fiber film obtained in the step (3) into required sizes according to specification requirements, coating ethanol on the fiber film and the middle moisture absorption layer, then attaching the fiber film and the middle moisture absorption layer, packaging the fiber film and the middle moisture absorption layer, and sterilizing the fiber film and the middle moisture absorption layer in a plasma sterilizer to obtain the wound dressing with antibacterial and bacteria warning functions.
The wound dressing prepared in this example was subjected to a moisture absorption test, which was carried out by the following specific procedures: the sterilized wound dressing was weighed and its weight (g) recorded, and then the wound dressing was completely soaked in deionized water until its weight did not change and its weight was recorded.
And (3) test results: the weight of the wound dressing after absorbing the deionized water is 7-9 times of the original weight of the wound dressing.
The wound dressing prepared by the embodiment is subjected to antibacterial and bacteria-carrying warning tests, the bacteria used in the tests are respectively staphylococcus aureus and escherichia coli, and the specific operation is as follows: aiming at an antibacterial test, a traditional ten-fold dilution method is adopted, bacteria are dropped on a wound dressing to contact for 2 hours, then the wound dressing is repeatedly washed by normal saline, the washed bacteria are coated on an agar plate, the colony number is counted after 1-day culture, and the bacteriostasis rate is calculated; for the bacteria-carrying warning test, the bacterial liquid with low concentration (OD 600 is 0.8) and high concentration (OD 600 is 2.2) was dropped on the wound dressing, and the color was observed and recorded at 0h, 6h and 48 h.
And (3) test results: the wound dressing prepared by the embodiment has good inhibition effect on bacteria, and the inhibition rates on staphylococcus aureus and escherichia coli are 99% and 75% respectively. The wound dressing prepared in the embodiment can realize the indication of bacterial infection through visual color change, and when the concentration of the bacterial liquid is OD600 ═ 0.8, the wound dressing can maintain the blue color after 6 hours or even 48 hours because the wound dressing has antibacterial activity due to the addition of the octadecyl trimethyl ammonium chloride; when the concentration of the bacterial liquid is 2.2 at OD600, the wound dressing is blue at 0h, the wound dressing is faded to a certain extent (from blue to white) at 6h, and the whole wound dressing is white at 48 h.
Example 2
The steps of this example are as follows:
(1) preparing the polyvinyl alcohol foam with compact top surface and porous lower part
Dissolving polyvinyl alcohol in deionized water at 100 ℃, cooling to room temperature, adding butyraldehyde and concentrated sulfuric acid, uniformly mixing to form a reaction liquid, heating the reaction liquid in an oven to 90 ℃, and keeping the temperature for 1h to obtain a polyvinyl alcohol foam body with a compact top surface and a porous structure at the lower part, wherein in the reaction liquid, the concentration of the polyvinyl alcohol is 100g/L, the ratio of the mass of the polyvinyl alcohol to the volume of the butyraldehyde is 1:0.5, the ratio of the mass of the polyvinyl alcohol to the volume of the concentrated sulfuric acid is 1:0.05, the mass unit of the polyvinyl alcohol is g, and the volume units of the butyraldehyde and the concentrated sulfuric acid are mL;
(2) soaking and drying
Repeatedly cleaning the polyvinyl alcohol foam obtained in the step (1) with deionized water, removing unreacted butyraldehyde and concentrated sulfuric acid, then placing the cleaned polyvinyl alcohol foam into a soaking solution composed of methylene blue, dodecyl triphenyl phosphonium bromide and deionized water, soaking for 1h at room temperature, taking out the polyvinyl alcohol foam from the soaking solution after soaking is finished, and carrying out freeze vacuum drying at-20 ℃ to remove the contained deionized water, thus obtaining an intermediate moisture absorption layer and an external protective layer which contain an integrated structure of the methylene blue and the dodecyl triphenyl phosphonium bromide, wherein the concentration of the methylene blue in the soaking solution is 1g/L, and the concentration of the dodecyl triphenyl phosphonium bromide is 0.06 g/L;
(3) preparation of fibrous membrane with blood coagulation function
Preparing a fiber film with a blood coagulation function by adopting an electrostatic spinning method, wherein chitosan is used as an electrostatic spinning raw material, the chitosan is dissolved in deionized water to prepare electrostatic spinning slurry, the concentration of the chitosan in the slurry is 50g/L, the slurry is filled into an injector of electrostatic spinning equipment, the distance between the needle point of the injector and a receiver of the electrostatic spinning equipment is controlled to be 10cm, and the electrostatic spinning equipment is started to work to prepare the fiber film with the blood coagulation function;
(4) cutting, combining, packaging and sterilizing
And (3) cutting the integrated middle moisture absorption layer and the external protective layer obtained in the step (2) and the fiber film obtained in the step (3) into required sizes according to specification requirements, coating ethanol on the fiber film and the middle moisture absorption layer, then attaching the fiber film and the middle moisture absorption layer, packaging the fiber film and the middle moisture absorption layer, and sterilizing the fiber film and the middle moisture absorption layer in a plasma sterilizer to obtain the wound dressing with antibacterial and bacteria warning functions.
Example 3
The steps of this example are as follows:
(1) preparing the polyvinyl alcohol foam with compact top surface and porous lower part
Dissolving polyvinyl alcohol in deionized water at 120 ℃, cooling to room temperature, adding butyraldehyde and concentrated sulfuric acid, uniformly mixing to form a reaction liquid, heating the reaction liquid in an oven to 80 ℃, and keeping the temperature for 2 hours to obtain a polyvinyl alcohol foam body with a compact top surface and a porous structure at the lower part, wherein in the reaction liquid, the concentration of the polyvinyl alcohol is 50g/L, the ratio of the mass of the polyvinyl alcohol to the volume of the butyraldehyde is 1:1, the ratio of the mass of the polyvinyl alcohol to the volume of the concentrated sulfuric acid is 1:0.04, the mass unit of the polyvinyl alcohol is g, and the volume unit of the butyraldehyde and the concentrated sulfuric acid is mL;
(2) soaking and drying
Repeatedly cleaning the polyvinyl alcohol foam obtained in the step (1) with deionized water, removing unreacted butyraldehyde and concentrated sulfuric acid, then placing the cleaned polyvinyl alcohol foam into a soaking solution composed of methylene blue, hexadecyl trimethyl ammonium bromide and deionized water, soaking for 1h at room temperature, taking out the polyvinyl alcohol foam from the soaking solution after soaking is finished, and carrying out freeze vacuum drying at-20 ℃ to remove the contained deionized water, thus obtaining an intermediate moisture absorption layer and an external protective layer which have an integrated structure and contain the methylene blue and the hexadecyl trimethyl ammonium bromide, wherein in the soaking solution, the concentration of the methylene blue is 5g/L, and the concentration of the hexadecyl trimethyl ammonium bromide is 0.04 g/L;
(3) preparation of fibrous membrane with blood coagulation function
Preparing a fiber film with a blood coagulation function by adopting an electrostatic spinning method, wherein the raw material of the electrostatic spinning is sodium alginate, dissolving the sodium alginate in deionized water to prepare electrostatic spinning slurry, the concentration of the sodium alginate in the slurry is 100g/L, loading the slurry into an injector of electrostatic spinning equipment, controlling the distance between the needle point of the injector and a receiver of the electrostatic spinning equipment to be 10cm, and starting the electrostatic spinning equipment to work to prepare the fiber film with the blood coagulation function;
(4) cutting, combining, packaging and sterilizing
And (3) cutting the integrated middle moisture absorption layer and the external protective layer obtained in the step (2) and the fiber film obtained in the step (3) into required sizes according to specification requirements, coating ethanol on the fiber film and the middle moisture absorption layer, then attaching the fiber film and the middle moisture absorption layer, packaging the fiber film and the middle moisture absorption layer, and sterilizing the fiber film and the middle moisture absorption layer in a plasma sterilizer to obtain the wound dressing with antibacterial and bacteria warning functions.
Claims (5)
1. The wound dressing with both antibacterial and antibacterial warning functions consists of wound contact layer, middle moisture absorption layer and outer protecting layer
The wound contact layer is a fiber film with a blood coagulation function, the middle moisture absorption layer is polyvinyl alcohol porous foam containing methylene blue and an antibacterial agent, the outer protection layer is polyvinyl alcohol dense foam containing methylene blue and an antibacterial agent, the middle moisture absorption layer and the outer protection layer are of an integrated structure, and the wound contact layer and the middle moisture absorption layer are combined together; the antibacterial agent is quaternary ammonium salt or quaternary phosphonium salt;
the preparation method of the middle moisture absorption layer and the outer protective layer of the integrated structure comprises the following steps:
(1) preparing the polyvinyl alcohol foam with compact top surface and porous lower part
Dissolving polyvinyl alcohol in deionized water at 85-120 ℃, cooling to room temperature, adding formaldehyde or butyraldehyde and a catalyst concentrated sulfuric acid, uniformly mixing to form a reaction liquid, heating the reaction liquid to 80-90 ℃, and preserving heat for 1-2 hours to obtain a polyvinyl alcohol foam body with a compact top surface and a porous structure at the lower part;
(2) soaking and drying
Washing the polyvinyl alcohol foam obtained in the step (1) with deionized water to remove unreacted formaldehyde or butyraldehyde and a catalyst concentrated sulfuric acid, then placing the polyvinyl alcohol foam into a soaking solution composed of methylene blue, an antibacterial agent and deionized water, soaking at room temperature for at least 1 hour, taking out the polyvinyl alcohol foam from the soaking solution after soaking is finished, and carrying out freeze vacuum drying to obtain an intermediate moisture absorption layer and an external protective layer which are of an integrated structure and contain the methylene blue and the antibacterial agent;
the preparation method of the fiber film with the blood coagulation function comprises the following steps:
the fiber film with the blood coagulation function is prepared by adopting an electrostatic spinning method, wherein the electrostatic spinning raw material is one of alginate, chitosan and collagen, or sodium carboxymethylcellulose and polyvinyl alcohol.
2. The wound dressing with antibacterial and bacteria warning functions as claimed in claim 1, wherein in the reaction solution in the step (1), the concentration of polyvinyl alcohol is 50-100 g/L; the ratio of the mass of the polyvinyl alcohol to the volume of the formaldehyde or the butyraldehyde is 1 (0.5-1), wherein the mass unit of the polyvinyl alcohol is g, the volume unit of the formaldehyde or the butyraldehyde is mL, or the mass unit of the polyvinyl alcohol is kg, and the volume unit of the formaldehyde or the butyraldehyde is L; the ratio of the mass of the polyvinyl alcohol to the volume of the concentrated sulfuric acid serving as the catalyst is 1 (0.04-0.15), wherein the mass unit of the polyvinyl alcohol is g, and the volume unit of the concentrated sulfuric acid is mL, or the mass unit of the polyvinyl alcohol is kg, and the volume unit of the concentrated sulfuric acid is L.
3. The wound dressing with antibacterial and bacteria warning functions as claimed in claim 1 or 2, wherein the concentration of methylene blue in the soaking solution in step (2) is 0.5-5 g/L, and the concentration of the antibacterial agent is 0.04-0.10 g/L.
4. The wound dressing with the antibacterial and bacteria warning functions as claimed in claim 1 or 2, wherein the slurry for electrostatic spinning is prepared from an electrostatic spinning raw material and deionized water, and the concentration of the electrostatic spinning raw material in the slurry is 50-150 g/L; when the electrostatic spinning raw materials are sodium carboxymethyl cellulose and polyvinyl alcohol, the mass ratio of the sodium carboxymethyl cellulose to the polyvinyl alcohol is 1 (2-3).
5. The wound dressing with the antibacterial and bacteria-carrying warning functions as claimed in claim 3, wherein the slurry for electrostatic spinning is prepared from an electrostatic spinning raw material and deionized water, and the concentration of the electrostatic spinning raw material in the slurry is 50-150 g/L; when the electrostatic spinning raw materials are sodium carboxymethyl cellulose and polyvinyl alcohol, the mass ratio of the sodium carboxymethyl cellulose to the polyvinyl alcohol is 1 (2-3).
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