CN113075013A

CN113075013A - Solution preparation device and preparation method thereof and in-vitro diagnosis and analysis equipment

Info

Publication number: CN113075013A
Application number: CN202110347440.4A
Authority: CN
Inventors: 向裕; 柳邦源; 萧嘉浩; 贺旭林; 黄权敏
Original assignee: Zhuhai Livzon Diagnostics Inc
Current assignee: Zhuhai Livzon Diagnostics Inc
Priority date: 2021-03-31
Filing date: 2021-03-31
Publication date: 2021-07-06
Anticipated expiration: 2041-03-31
Also published as: CN113075013B

Abstract

A solution preparation device, a preparation method thereof and in-vitro diagnosis and analysis equipment relate to the field of medical equipment. The solution preparation device comprises a first liquid storage container, a second liquid storage container, a first blending container and a second blending container; the second mixing container is arranged at the top of the first mixing container and is communicated with the first mixing container through a connecting pipe; the connecting pipe is provided with a second sensor for detecting the height of the liquid level in the connecting pipe; a first infusion pump is arranged between the first liquid storage container and the first blending container; the top pipe is provided with a first sensor for detecting the height of the liquid level in the top pipe; a second infusion pump is arranged between the second liquid storage container and the first blending container. The solution preparation method is suitable for the solution preparation device. The in vitro diagnostic and analytical device comprises a solution preparation device. The invention provides a solution preparation device, a preparation method thereof and in-vitro diagnosis and analysis equipment, which can reduce the concentration deviation of a solution prepared from a washing solution to a certain extent, and have the advantages of simple structure and low cost.

Description

Solution preparation device and preparation method thereof and in-vitro diagnosis and analysis equipment

Technical Field

The invention relates to the field of medical equipment, in particular to a solution preparation device, a preparation method thereof and in-vitro diagnosis and analysis equipment.

Background

Currently, in vitro diagnosis is a widely used diagnostic method in the medical field, and judges human pathological changes by collecting body fluids, excretions and secretions of a human body to perform chemical composition or chemical reaction analysis. In vitro diagnostic methods include chemiluminescence assays, molecular diagnostics, immunodiagnosis, and the like. In a period like sudden and large-infectious diseases such as new coronavirus, hospitals need to detect a large number of samples every day, the detection amount of medical staff is increased, and therefore an in-vitro diagnosis device is required to have high working efficiency. The multiple immunity technology can realize the purpose of simultaneously detecting a plurality of markers in a reaction system by identifying chip patterns, and has the characteristics of high flux, full automation, high speed, random sample introduction and the like. Patent application CN201811115598.3 has disclosed a multiple immunoassay analyzer, which is widely used in hospitals.

The detection accuracy of the multiple immunization equipment depends on the recognition of chip patterns, and if the chips are stacked, superposed, stacked and the like in the recognition process, the final detection result is influenced. The multiple immunity analyzer reduces the occurrence probability of chip stacking, overlapping and stacking conditions by cleaning the chip by using the washing solution prepared by the solution preparation device. The concentration deviation of the washing liquid can interfere the chip washing effect, so that the precision of the detection result is influenced, and the detection accuracy is reduced. At present, the solution preparation device in a common multiple immunoassay analyzer has the problems of complex structure, high cost and large concentration deviation of the prepared solution.

Disclosure of Invention

The invention aims to provide a solution preparation device, a preparation method thereof and in-vitro diagnosis and analysis equipment, which can solve the technical problems of complex structure, high cost and large concentration deviation of prepared solution in the prior art to a certain extent.

In order to achieve the purpose, the invention provides the following technical scheme:

a solution preparation device comprises a first liquid storage container, a second liquid storage container, a first blending container and a second blending container;

the top of the second blending container is communicated with a top pipe, and the cross sectional area of the top pipe is smaller than that of the second blending container along the horizontal direction;

the second blending container is arranged at the top of the first blending container and is communicated with the first blending container through a connecting pipe; the cross section area of the second blending container in the horizontal direction and the cross section area of the first blending container are both larger than the cross section area of the connecting pipe;

the connecting pipe is provided with a second sensor for detecting the height of the liquid level in the connecting pipe; a first infusion pump is arranged between the first liquid storage container and the first blending container; the first infusion pump is used for conveying the first liquid in the first liquid storage container to the first blending container; the first infusion pump is electrically connected with the second sensor, when the second sensor monitors that the liquid level in the connecting pipe reaches a preset height, the second sensor outputs a corresponding signal to the control unit, and the control unit controls the first infusion pump to stop working;

the top pipe is provided with a first sensor for detecting the height of the liquid level in the top pipe; a second infusion pump is arranged between the second liquid storage container and the first blending container; the second infusion pump is used for conveying the second liquid in the second liquid storage container to the first blending container and enabling the liquid in the first blending container to reach the second blending container through the connecting pipe; the second infusion pump is electrically connected with the first sensor, when the first sensor monitors that the liquid level in the top pipe reaches a preset height, the first sensor outputs a corresponding signal to the control unit, and the control unit controls the second infusion pump to stop working;

the bottom of the first blending container is at least provided with a first liquid inflow channel A, a second liquid inflow channel B1, a second liquid inflow channel B2 and a liquid drainage channel C;

the first infusion pump is communicated with the first liquid inflow channel A, and the second infusion pump is respectively communicated with the second liquid inflow channel B1 and the second liquid inflow channel B2;

the projections of the axial direction of the second liquid inflow passage B1, the axial direction of the second liquid inflow passage B2, and the axial direction of the first kneading container on any spatial plane are not parallel to each other.

Optionally, a three-way structure is arranged between the second infusion pump and the first mixing container; the first end of the three-way structure is communicated with the second infusion pump, the second end of the three-way structure is communicated with the second liquid inflow channel B1 through a second one-way mechanism, and the third end of the three-way structure is communicated with the second liquid inflow channel B2 through a third one-way mechanism; the second one-way mechanism and the third one-way mechanism are respectively used for preventing the liquid in the first blending container from flowing out;

the solution preparation device further comprises a third liquid storage container which is communicated with the liquid drainage channel C;

the third liquid storage container is provided with a third sensor for monitoring the liquid level in the third liquid storage container;

a third infusion pump is arranged between the third liquid storage container and the first blending container; the third infusion pump is used for conveying the liquid in the first blending container to the third liquid storage container; the third transfer pump respectively with first sensor the second sensor with the third sensor electricity is connected, works as the monitoring of first sensor liquid level in the overhead pipe reaches and predetermines the height, the monitoring of second sensor liquid level in the connecting pipe reaches and predetermines the height and the monitoring of third sensor output corresponding signal to the control unit when liquid level in the third liquid storage container is not higher than and predetermines minimum height, is controlled by the control unit the third transfer pump begins work.

Optionally, a first one-way mechanism for preventing the liquid in the first blending container from flowing out is arranged on a pipeline between the first infusion pump and the first blending container;

a fourth one-way mechanism for enabling the liquid in the first blending container to flow out in one way is arranged on a pipeline between the third infusion pump and the first blending container;

the first one-way mechanism, the second one-way mechanism, the third one-way mechanism and the fourth one-way mechanism are all one-way solenoid valves;

the first one-way mechanism is electrically connected with the second sensor;

the second one-way mechanism and the third one-way mechanism are electrically connected with the first sensor respectively;

the fourth one-way mechanism is electrically connected with the first sensor, the second sensor and the third sensor respectively;

the bottom of the inner surface of the first blending container is in a conical surface shape; the liquid discharge channel C is arranged at the lowest part of the bottom of the inner surface of the first blending container;

the first liquid inflow channel A is provided with a pointed one-way structure for preventing the liquid in the first mixing container from flowing out;

the second liquid inflow passage B1, the second liquid inflow passage B2 and the liquid discharge passage C are all groove structures;

a first flow sensor for monitoring bubbles in the pipe is arranged between the first liquid storage container and the first blending container; the first flow sensor is electrically connected with the first infusion pump and is used for correspondingly controlling the first infusion pump to stop working when monitoring bubbles;

a second flow sensor for monitoring bubbles in the pipe is arranged between the second liquid storage container and the first blending container; the second flow sensor is electrically connected with the second infusion pump and is used for correspondingly controlling the second infusion pump to stop working when monitoring bubbles;

a third flow sensor for monitoring bubbles in the tube is arranged between the first mixing container and the third infusion pump; the third flow sensor is electrically connected with the third infusion pump and is used for correspondingly controlling the third infusion pump to stop working when monitoring bubbles;

the first blending container comprises a first container top, a first container body and a first container bottom which are sequentially connected from top to bottom; the cross-sectional area of the first container body is greater than the cross-sectional areas of the top of the first container and the bottom of the first container, respectively;

the second blending container comprises a second container top, a second container body and a second container bottom which are sequentially connected from top to bottom, and the cross sectional area of the second container body is respectively larger than that of the second container top and that of the second container bottom;

the top of the first container is communicated with the bottom of the second container through the connecting pipe;

the top pipe is arranged on the top of the second container;

a first magnetic stirrer is arranged at the bottom of the first blending container, and at least one first stirrer is arranged in the first blending container;

a second magnetic stirrer is arranged at the bottom of the second blending container, and at least one second stirrer is arranged in the second blending container;

and the top of the jacking pipe is provided with an exhaust one-way mechanism for preventing liquid from rushing out.

A pipeline between a third infusion pump and a first blending container is provided with a fourth one-way mechanism for enabling liquid in the first blending container to flow out in a one-way mode; the method comprises the following steps:

s1: starting a solution preparation device;

s2: the first liquid in the first liquid storage container is conveyed into the first mixing container by the first liquid conveying pump through the first one-way mechanism, meanwhile, the first one-way mechanism is in a communicated state, and the second one-way mechanism and the third one-way mechanism are in a closed state;

when the second sensor monitors that the liquid level reaches a preset height, the second sensor outputs a signal to the control unit, the control unit controls the first infusion pump to stop working, and meanwhile, the first one-way mechanism, the second one-way mechanism, the third one-way mechanism and the fourth one-way mechanism are in a closed state; otherwise, the first infusion pump continues to convey the first liquid in the first liquid storage container to the first blending container;

s3, the control unit controls the first infusion pump to stop working, and at the same time, the control unit controls the second infusion pump to convey the second liquid in the second liquid storage container to the first mixing container through the second one-way mechanism and the third one-way mechanism respectively through the three-way structure, and meanwhile, the second one-way mechanism and the third one-way mechanism are in a communicated state, and the first one-way mechanism is in a closed state;

the second liquid enters the first mixing container through a second liquid inflow channel B1 and a second liquid inflow channel B2 respectively and forms a counterclockwise or clockwise vortex with the original liquid in the first mixing container, so that the liquid in the first mixing container is mixed with the liquid in the second mixing container, and at the moment, the second sensor can detect a liquid level signal;

when the first sensor monitors that the liquid level reaches a preset height, the first sensor outputs a signal to the control unit, the control unit controls the second infusion pump to stop working, and meanwhile, the first one-way mechanism, the second one-way mechanism, the third one-way mechanism and the fourth one-way mechanism are in a closed state; otherwise, the second liquid pump continues to convey the second liquid in the second liquid storage container to the first mixing container;

s4: the control unit controls the second infusion pump to stop working, simultaneously outputs signals to the control unit from the first sensor and the second sensor, controls the third infusion pump and the fourth one-way mechanism to be sequentially started, and discharges liquid in the solution preparation device into a third liquid storage container;

after the liquid in the solution preparation device is completely discharged, the control unit controls the third infusion pump to stop working, and at the moment, the first one-way mechanism, the second one-way mechanism, the third one-way mechanism and the fourth one-way mechanism are in a closed state.

Optionally, in step S3, before the "control unit controls the first infusion pump to stop working", the control unit controls the first infusion pump to stop working until the liquid level in the first blending container is unchanged, specifically including:

after the control unit controls the first infusion pump to pause for a certain time, the second sensor can still monitor that the liquid level reaches the preset height, and the first infusion pump is not started; otherwise, starting the first infusion pump again until the second sensor monitors that the liquid level reaches the preset height; when the first infusion pump is started again, the first one-way mechanism is in a communicated state, and the second one-way mechanism, the third one-way mechanism and the fourth one-way mechanism are in a closed state;

and/or the presence of a gas in the gas,

in step S4, before the "control unit controls the second infusion pump to stop working", the control unit controls the second infusion pump to stop working until the liquid level in the second blending container is unchanged, which specifically includes:

after the control unit controls the second infusion pump to pause for a certain time, the first sensor can still monitor that the liquid level reaches the preset height, and the second infusion pump is not started; otherwise, the second infusion pump is started again until the first sensor monitors that the liquid level reaches the preset height; when the second infusion pump is started again, the second one-way mechanism and the third one-way mechanism are in a communicated state, and the first one-way mechanism and the fourth one-way mechanism are in a closed state.

Optionally, a first magnetic stirrer is arranged at the bottom of the first blending container, and at least one first stirrer is arranged in the first blending container; a second magnetic stirrer is arranged at the bottom of the second blending container, and at least one second stirrer is arranged in the second blending container;

the conveying speed for restarting the first infusion pump is less than the conveying speed for starting the first infusion pump for the first time;

the conveying speed for restarting the second infusion pump is less than the conveying speed for starting the second infusion pump for the first time;

and when the control unit controls the second infusion pump to stop working, the control unit simultaneously starts a first magnetic stirrer arranged in the first blending container and a second magnetic stirrer arranged in the second blending container, and the solution in the blending solution preparation device is prepared.

Optionally, the solution preparation method further comprises:

s5: repeating the steps S1-S3 to prepare a new round of liquid;

the first one-way mechanism, the second one-way mechanism and the third one-way mechanism are in a closed state, and the fourth one-way mechanism is in an open state; meanwhile, the third liquid storage container, the first blending container and the second blending container are all filled with prepared liquid, and the solution preparation in the solution preparation device and the liquid supplement in the third liquid storage container are completed;

alternatively, in step S3, the liquid enters the second mixing container 15, and the gas in the solution preparation apparatus is discharged through the top pipe 26.

Alternatively, in step S4, the "draining of liquid in the solution preparation apparatus" includes: the liquid level in the solution preparation device is lower than the second sensor so as to interrupt the signal of the second sensor, and then no induction liquid flows through the third flow sensor within a fixed time; the third flow sensor is arranged between the first blending container and the third infusion pump; or the liquid level in the solution preparation device is lower than the second sensor, so that the signal of the second sensor is interrupted, then the closing time of the third infusion pump is delayed, and the fourth one-way mechanism and the third infusion pump are closed when the specified time is reached;

optionally, step S1 includes, when the liquid level in the third liquid storage container monitored by the third sensor is lower than the preset minimum height, starting the liquid preparation by the solution preparation device, otherwise, not starting the liquid preparation by the solution preparation device; when the liquid level in the third liquid storage container monitored by the third sensor is not lower than the preset liquid height, the solution preparation device does not start liquid preparation, otherwise, the solution preparation device starts liquid preparation; wherein the preset liquid height is higher than the preset lowest height.

Optionally, when the solution preparation process is terminated suddenly, the first one-way mechanism, the second one-way mechanism and the third one-way mechanism are closed, and the first infusion pump and the second infusion pump are closed;

then, opening a fourth one-way mechanism, communicating the N end and the C end of the waste washing three-way mechanism, enabling a third infusion pump to work, conveying the liquid in the first mixing container and the second mixing container into a waste liquid container through the waste washing three-way mechanism until the liquid level in the solution preparation device is lower than that of the second sensor, and enabling no induction liquid to flow through the third flow sensor within a fixed time; the third flow sensor is arranged between the first mixing container and the third infusion pump, and the waste washing three-way mechanism 275 comprises an N end communicated with the third infusion pump, a C end communicated with the waste liquid container and an O end communicated with the third liquid storage container;

and then the control unit controls the third infusion pump to stop working, closes the fourth one-way mechanism, communicates the N end and the O end of the waste washing three-way mechanism, and then starts the solution preparation device.

An in vitro diagnostic and analytical device comprising a solution preparation means or using a solution preparation method, further comprising a control unit and a detection means; a third liquid storage container of the solution preparation device provides washing liquid for the detection device; the solution preparation device is electrically connected with the control unit.

The invention has the following beneficial effects:

the invention provides a solution preparation device, a preparation method thereof and in-vitro diagnostic and analytical equipment, wherein a second blending container is arranged at the top of a first blending container, the second blending container is communicated with the first blending container through a connecting pipe, a first liquid in a first liquid storage container is conveyed to the first blending container by a first liquid conveying pump, the liquid level in the first blending container rises and overflows to the connecting pipe, a second sensor outputs a corresponding signal to a control unit when monitoring that the liquid level in the connecting pipe reaches a preset height, and the control unit controls the first liquid conveying pump to stop working so as to finish the injection work of the first liquid. Then, the second liquid pump enables the second liquid in the second liquid storage container to be conveyed to the first mixing container and mixed with the first liquid in the first mixing container, and the mixed liquid reaches the second mixing container through the connecting pipe; the liquid level in the second mixing container rises and overflows to the top pipe, the first sensor outputs a corresponding signal to the control unit when monitoring that the liquid level in the top pipe reaches a preset height, and the control unit controls the second infusion pump to stop working, so that the injection work of the second liquid and the mixing work of the first liquid and the second liquid are completed. The second sensor is arranged on the connecting pipe with a relatively small cross section area, and the first sensor is arranged on the top pipe, so that the control precision of the injection amount of the first liquid and the second liquid is respectively improved, and the concentration error caused by the detection error of the sensors can be reduced. Through the axial of second liquid inflow passageway B1, the axial of second liquid inflow passageway B2 and the axial of first mixing container in the arbitrary plane in space projection all is not parallel to each other, with when pouring into the second liquid into first mixing container, second liquid from second liquid inflow passageway B1 injection first mixing container in with pour into the second liquid formation vortex in the first mixing container into from second liquid inflow passageway B2, and mix with original liquid in the first mixing container, the mixing degree of first liquid and second liquid has greatly been improved, can effectively reduce the solution concentration deviation after the configuration liquid is prepared. Compare in prior art solution preparation device in the conventional use need electric drive's agitator etc. play the device of mixing effect, solution preparation device accomplishes the solution mixing through physical structure, its simple structure, the cost is lower.

In order to make the aforementioned and other objects, features and advantages of the present application more comprehensible, preferred embodiments accompanied with figures are described in detail below.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.

FIG. 1 is a schematic structural diagram of a solution preparing apparatus according to an embodiment of the present invention;

FIG. 2 is an enlarged view of a portion of the solution dispensing apparatus shown in FIG. 1;

FIG. 3 is a perspective view of a solution dispensing apparatus provided in accordance with an embodiment of the present invention;

FIG. 4 is a schematic structural diagram of a solution preparing apparatus according to an embodiment of the present invention;

FIG. 5 is a sectional view taken along line A-A of the solution preparing apparatus shown in FIG. 4;

FIG. 6 is a sectional view taken along line B-B of the solution preparing apparatus shown in FIG. 5;

FIG. 7 is a cross-sectional view taken along line C-C of the solution preparing apparatus shown in FIG. 5;

FIG. 8 is a cross-sectional view taken along line D-D of the solution preparing apparatus shown in FIG. 5;

fig. 9 is a flowchart of a solution configuration method according to an embodiment of the present invention.

Icon: 11-a first liquid storage container; 12-a second liquid storage container; 13-a third liquid storage container; 14-a first blending container; 141-first container top; 142-a first container body; 143-first container bottom; 15-a second mixing container; 151-second container top; 152-a second container body; 153-second container bottom; 154-a second drainage channel; 16-a connecting tube; 17-a first infusion pump; 18-a second infusion pump; 19-a third infusion pump; 20-a first sensor; 21-a second sensor; 22-a first magnetic stirrer; 23-a second magnetic stirrer; 24-a first stirrer; 25-a second stirrer; 26-jacking pipes; 27-a third flow sensor; 28-a second flow sensor; 29-a first flow sensor; 30-a third sensor; a 32-tee configuration; 33-a waste liquid container; 271-a first one-way mechanism; 272-a second one-way mechanism; 273-a third one-way mechanism; 274-a fourth one-way mechanism; 275-waste washing tee mechanism; 276-exhaust one-way mechanism.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or the orientations or positional relationships that the products of the present invention are conventionally placed in use, and are only used for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the devices or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," "third," and the like are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance.

Furthermore, the terms "horizontal", "vertical", "overhang" and the like do not imply that the components are required to be absolutely horizontal or overhang, but may be slightly inclined. For example, "horizontal" merely means that the direction is more horizontal than "vertical" and does not mean that the structure must be perfectly horizontal, but may be slightly inclined.

In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

Some embodiments of the invention are described in detail below with reference to the accompanying drawings. The embodiments described below and the features of the embodiments can be combined with each other without conflict.

Examples

Referring to fig. 1 to 9, a solution preparing apparatus, a preparing method thereof and an in vitro diagnostic and analysis apparatus are provided in the present embodiment, and fig. 1 is a schematic structural diagram of the solution preparing apparatus provided in the present embodiment; FIG. 2 is an enlarged view of a portion of the solution dispensing apparatus shown in FIG. 1; fig. 3 is a perspective view of the solution preparing apparatus provided in this embodiment; fig. 4 is a schematic structural view of a solution preparation apparatus according to this embodiment, fig. 5 is a sectional view taken along a direction a-a of the solution preparation apparatus shown in fig. 4, and fig. 6 to 8 are sectional views taken along a direction B-B to a direction D-D of the solution preparation apparatus shown in fig. 5. Fig. 9 is a flowchart of a solution configuration method provided in this embodiment.

The solution preparation device provided by the embodiment is used for instruments and equipment such as a multiple immunoassay analyzer which have high requirements on the accuracy of solution concentration.

Referring to fig. 1 to 8, the solution preparation apparatus includes a first liquid storage container 11, a second liquid storage container 12, a first blending container 14, and a second blending container 15; a first liquid storage container 11 for storing a first liquid, and a second liquid storage container 12 for storing a second liquid; optionally, the first liquid and the second liquid are any liquids that are miscible; in this embodiment, the first liquid is, for example, a washing stock solution, and the second liquid is, for example, purified water.

The top of the second mixing container 15 is communicated with a top pipe 26, and the cross sectional area of the top pipe 26 is smaller than that of the second mixing container 15 along the horizontal direction; optionally, the top of the top pipe 26 is used to vent the gas in the second mixing vessel 15.

The second blending container 15 is arranged at the top of the first blending container 14, and the second blending container 15 is communicated with the first blending container 14 through a connecting pipe 16; the cross-sectional area of the second mixing vessel 15 in the horizontal direction and the cross-sectional area of the first mixing vessel 14 are both larger than the cross-sectional area of the connecting pipe 16; when the cross-sectional areas of the first mixing vessel 14, the second mixing vessel 15, and the connecting pipe 16 are circular, the diameter of the connecting pipe 16 is smaller than the diameter of the first mixing vessel 14 and the diameter of the second mixing vessel 15. Optionally, a connecting tube 16 communicates with the top of the first blending vessel 14 and the connecting tube 16 communicates with the bottom of the second blending vessel 15.

The connecting pipe 16 is provided with a second sensor 21 for detecting the height of the liquid level in the connecting pipe 16; a first infusion pump 17 is arranged between the first liquid storage container 11 and the first blending container 14; the first infusion pump 17 is used for delivering the first liquid in the first liquid storage container 11 to the first blending container 14; the first infusion pump 17 is electrically connected with the second sensor 21, when the second sensor 21 monitors that the liquid level in the connecting pipe 16 reaches a preset height, the second sensor 21 outputs a corresponding signal to the control unit, and the control unit controls the first infusion pump 17 to stop working, so that the injection work of the first liquid is completed. The cross-sectional area of the second mixing container 15 in the horizontal direction and the cross-sectional area of the first mixing container 14 are both larger than the cross-sectional area of the connecting pipe 16, that is, the diameter of the position where the second sensor 21 is located is smaller, so that the control precision of the injection amount of the first liquid is improved, and the concentration error caused by the detection error of the sensor can be reduced.

The top pipe 26 is provided with a first sensor 20 for detecting the liquid level in the top pipe 26; a second infusion pump 18 is arranged between the second liquid storage container 12 and the first blending container 14; the second infusion pump 18 is used for delivering the second liquid in the second liquid storage container 12 to the first blending container 14, and enabling the liquid in the first blending container 14 to reach the second blending container 15 through the connecting pipe 16; the second infusion pump 18 is electrically connected with the first sensor 20, when the first sensor 20 monitors that the liquid level in the top pipe 26 reaches a preset height, the first sensor 20 outputs a corresponding signal to the control unit, and the control unit controls the second infusion pump 18 to stop working, so that the injection work of the second liquid and the mixing work of the first liquid and the second liquid are completed. The cross-sectional area of the top pipe 26 is smaller than that of the second mixing container 15 along the horizontal direction, that is, the diameter of the position of the first sensor 20 is smaller, so that the control precision of the injection amount of the second liquid is improved, and the concentration error caused by the detection error of the sensor can be reduced.

Optionally, the bottom of the first mixing container 14 is provided with at least a first liquid inflow passage a, a second liquid inflow passage B1, a second liquid inflow passage B2, and a drainage passage C.

The first infusion pump 17 is in communication with the first fluid inflow channel a, that is, the first infusion pump 17 is configured to deliver the first fluid in the first fluid storage container 11 to the first mixing container 14 through the first fluid inflow channel a.

The second infusion pump 18 is communicated with the second liquid inflow passage B1 and the second liquid inflow passage B2, respectively; that is, the second infusion pump 18 is used to transfer the second liquid in the second liquid storage container 12 to the first mixing container 14 through the second liquid inflow passage B1 and the second liquid inflow passage B2, respectively.

Optionally, the projections of the axial direction of the second liquid inflow passage B1, the axial direction of the second liquid inflow passage B2, and the axial direction of the first mixing container 14 in any spatial plane are not parallel to each other. That is, the projections of the axial direction of the second liquid inflow passage B1, the axial direction of the second liquid inflow passage B2, and the axial direction of the first kneading container 14 on any spatial plane are not parallel to each other. Adopt this design to make the second liquid from second liquid inflow channel B1 injection in first mixing container 14, form the vortex with the second liquid from second liquid inflow channel B2 injection in first mixing container 14, and mix with original liquid in first mixing container 14, greatly improved the mixing degree of first liquid with the second liquid, can effectively reduce the solution concentration deviation after the preparation of configuration liquid, and then reduced because of the problem that configuration liquid concentration fluctuates and influences final detection data. The mixing mode can replace the mode of mixing liquid by adopting a motor mode by adopting a fluid mechanics principle, or can reduce the time, power and the like of mixing liquid by adopting the motor mode, saves energy to a certain extent, and has simple structure and lower cost.

Alternatively, as shown in fig. 6 and 8, the angle between the axial direction of the second liquid inflow passage B1 and the cross section of the first mixing container 14 is the same as the angle between the axial direction of the second liquid inflow passage B2 and the cross section of the first mixing container 14. Optionally, an included angle between the axial direction of the second liquid inflow passage B1 and the cross section of the first mixing container 14 is greater than 0 ° and less than 90 °, so as to enhance the mixing effect.

In the solution preparation device in this embodiment, the second blending container 15 is disposed at the top of the first blending container 14, the second blending container 15 is communicated with the first blending container 14 through the connecting pipe 16, the first infusion pump 17 delivers the first liquid in the first liquid storage container 11 to the first blending container 14, the liquid level in the first blending container 14 rises and overflows to the connecting pipe 16, the second sensor 21 outputs a corresponding signal to the control unit when monitoring that the liquid level in the connecting pipe 16 reaches a preset height, and the control unit controls the first infusion pump 17 to stop working, thereby completing the injection work of the first liquid. Then, the second liquid pump 18 conveys the second liquid in the second liquid storage container 12 to the first kneading container 14, and mixes the second liquid with the first liquid in the first kneading container 14, and the mixed liquid reaches the second kneading container 15 through the connecting pipe 16; the liquid level in the second mixing container 15 rises and overflows to the top pipe 26, the first sensor 20 outputs a corresponding signal to the control unit when monitoring that the liquid level in the top pipe 26 reaches a preset height, and the control unit controls the second infusion pump 18 to stop working, so that the injection work of the second liquid and the mixing work of the first liquid and the second liquid are completed. The second sensor 21 is provided in the connection pipe 16 having a relatively small cross-sectional area, and the first sensor 20 is provided in the top pipe 26, so that the accuracy of controlling the injection amounts of the first liquid and the second liquid, respectively, is improved, and the concentration error caused by the sensor detection error can be reduced. The axial direction of the second liquid inflow channel B1, the axial direction of the second liquid inflow channel B2 and the axial direction of the first mixing container 14 are not parallel to each other in the projection of any spatial plane, so that when the second liquid is injected into the first mixing container 14, the second liquid injected into the first mixing container 14 from the second liquid inflow channel B1 and the second liquid injected into the first mixing container 14 from the second liquid inflow channel B2 form a vortex, and are mixed with the original liquid in the first mixing container 14, the mixing degree of the first liquid and the second liquid is greatly improved, and the concentration deviation of the solution prepared from the configured liquid can be effectively reduced. The solution preparation device in the embodiment has a simple structure and low cost.

The solution preparation device in this embodiment can determine the volumes of the first mixing container 14 and the second mixing container 15 according to the volume ratio of the required first liquid to the second liquid and the volume of the mixed solution, so as to automatically prepare the solution, and the first liquid and the second liquid are injected from the bottom of the first mixing container 14, so that the generation of bubbles during the injection of the liquid into the containers can be reduced.

Referring to fig. 1-8, in an alternative embodiment, a three-way structure 32 is provided between the second infusion pump 18 and the first blending container 14; a first end of the three-way structure 32 is communicated with the second infusion pump 18, a second end of the three-way structure 32 is communicated with the second liquid inflow channel B1 through the second one-way mechanism 272, and a third end of the three-way structure 32 is communicated with the second liquid inflow channel B2 through the third one-way mechanism 273; the second check mechanism 272 and the third check mechanism 273 are each configured to prevent the liquid in the first kneading container 14 from flowing out. The second one-way mechanism 272 and the third one-way mechanism 273 prevent the liquid in the first mixing container 14 from flowing to the second liquid storage container 12, which affects the overall solution preparation concentration.

The solution preparation device also comprises a third liquid storage container 13, and the third liquid storage container 13 is communicated with the liquid drainage channel C; for example, the third liquid storage container 13 is a washing liquid tank for storing the liquid after the preparation is completed. It will be understood by those skilled in the art that the third fluid storage container 13 may not be provided, and that the output of the third infusion pump 19 may be connected to a device requiring use of the washing preparation fluid.

The third liquid storage container 13 is provided with a third sensor 30 for monitoring the liquid level in the third liquid storage container 13; when the liquid level is lower than the monitoring height of the third sensor 30, the liquid level in the third liquid storage container 13 is too low, and liquid needs to be supplemented into the third liquid storage container 13; when the liquid level is not lower than the monitored level of the third sensor 30, it indicates that the liquid in the third liquid storage container 13 is sufficient and that the liquid in the third liquid storage container 13 does not need to be replenished.

Optionally, a third infusion pump 19 is arranged between the third liquid storage container 13 and the first blending container 14; the third infusion pump 19 is used for delivering the liquid in the first blending container 14 to the third liquid storage container 13; the third infusion pump 19 is electrically connected with the first sensor 20, the second sensor 21 and the third sensor 30 respectively, when the first sensor 20 monitors that the liquid level in the top pipe 26 reaches the preset height, the second sensor 21 monitors that the liquid level in the connecting pipe 16 reaches the preset height, and the third sensor 30 monitors that the liquid level in the third liquid storage container 13 is not higher than the preset minimum height, a corresponding signal is output to the control unit, and the control unit controls the third infusion pump 19 to start working.

For example, when the liquid level of the third liquid storage container 13 is lower than the lowest detection line of the third sensor 30 and the second sensor 21 and the first sensor 20 detect signals, the third sensor 30 outputs signals to control the three-way washing mechanism 275, the fourth one-way mechanism 274 and the third infusion pump 19 to open, so as to completely discharge the liquids in the first mixing container 14 and the second mixing container 15 into the third liquid storage container 13. A third flow sensor 27 is arranged between the fourth one-way mechanism 274 and the third infusion pump 19, and after the heights of the prepared solutions in the second blending container 15 and the first blending container 14 are sequentially lower than the lowest detection lines of the first sensor 20 and the second sensor 21, the signals are interrupted until the third flow sensor 27 does not sense the flow of liquid, and then the fourth one-way mechanism 274 is sequentially controlled to be closed and the third infusion pump 19 is stopped. At this time, the liquids in the first kneading vessel 14 and the second kneading vessel 15 have entered the third liquid storage vessel 13. With this arrangement, the amount of liquid in the third liquid storage container 13 can be ensured to be sufficient, and the deviation of the solution preparation concentration caused by incomplete discharge of the liquid when the solution preparation is repeated in the solution preparation device can be reduced.

Optionally, the number of the first infusion pump 17 and the second infusion pump 18 is one or more; optionally, the number of the first infusion pump 17 and the second infusion pump 18 is one for cost saving.

Optionally, the number of the third infusion pumps 19 is one or more; optionally, the number of the third infusion pumps 19 is one to save costs.

Referring to fig. 1 and 2, in an alternative of the present embodiment, a first one-way mechanism 271 for preventing the liquid in the first kneading container 14 from flowing out is provided on a pipeline between the first infusion pump 17 and the first kneading container 14; that is, the first infusion pump 17 communicates with the first fluid inflow passage a through the first check mechanism 271. The first one-way mechanism 271 prevents the liquid in the first mixing container 14 from flowing to the first liquid storage container 11, which affects the overall solution preparation concentration.

Optionally, a fourth one-way mechanism 274 for making the liquid in the first blending container 14 flow out in one way is arranged on a pipeline between the third infusion pump 19 and the first blending container 14; that is, the discharge passage C communicates with the third infusion pump 19 through the fourth check mechanism 274. The liquid in the first kneading vessel 14 is made to flow in one direction to the third liquid storage vessel 13 by the fourth one-way mechanism 274.

Optionally, a waste washing tee mechanism 275 is arranged between the third infusion pump 19 and the third liquid storage container 13; optionally, the waste three-way mechanism 275 includes an N-port in communication with the third infusion pump 19, a C-port in communication with the waste liquid container 33, and an O-port in communication with the third liquid storage container 13. Optionally, the waste washing tee-joint mechanism 275 is a structure that realizes one-way control by electromagnetism.

Alternatively, the first one-way mechanism 271, the second one-way mechanism 272, the third one-way mechanism 273 and the fourth one-way mechanism 274 may be respectively one-way solenoid valves, may also be respectively leather cup structures that implement one-way control through physical structures, or may be other mechanisms that implement one-way liquid flow. Alternatively, the first one-way mechanism 271, the second one-way mechanism 272, the third one-way mechanism 273, and the fourth one-way mechanism 274 are all one-way solenoid valves; by adopting the one-way solenoid valve, the interference of the liquid siphoning phenomenon when the leather cup is used on the liquid in the first liquid storage container 11 and the second liquid storage container 12 can be avoided.

Optionally, the first one-way mechanism 271 is electrically connected with the second sensor 21; the output signal of the second sensor 21 and the activation signal are used to control the first one-way mechanism 271.

Alternatively, the second one-way mechanism 272 and the third one-way mechanism 273 are electrically connected to the first sensor 20, respectively; the output signal of the first sensor 20 and the activation signal are used to control the second one-way mechanism 272 and the third one-way mechanism 273.

Alternatively, the fourth one-way mechanism 274 is electrically connected to the first sensor 20, the second sensor 21, and the third sensor 30, respectively; the output signals of the first sensor 20, the second sensor 21, and the third sensor 30 are used to control the fourth one-way mechanism 274. Alternatively, the first sensor 20, the second sensor 21, and the third sensor 30 may be selected from, but not limited to, a capacitive sensor, an ultrasonic sensor, an infrared sensor, and the like.

Optionally, the bottom of the inner surface of the first blending container 14 is conical; the drainage passage C is provided at the lowest portion of the bottom of the inner surface of the first kneading container 14 to reduce the residual amount of the liquid in the first kneading container 14 at the time of drainage. Optionally, the drainage channel C is located at the very center of the bottom of the first mixing container 14.

Optionally, the first liquid inflow channel a is provided with a pointed one-way structure for preventing the liquid in the first mixing container 14 from flowing out; by adopting the pointed one-way structure, the filler or the like in the first kneading vessel 14 cannot obstruct the inflow of the first liquid. The filler may be a stirrer, or may be an object of any shape that can occupy a space volume and does not affect the solution distribution, and that is placed to adjust the volumes of the first kneading vessel 14 and the second kneading vessel 15.

Optionally, the second liquid inflow passage B1, the second liquid inflow passage B2 and the liquid discharge passage C are all groove structures; in order to generate the vortex flow, the second liquid inflow passage B1 and the second liquid inflow passage B2 cannot adopt a pointed one-way structure, and therefore the second liquid inflow passage B1 and the second liquid inflow passage B2 adopt a drain valve provided with a groove structure. Be groove structure through second liquid inflow channel B1, second liquid inflow channel B2 and flowing back passageway C to reduce liquid and remain, prepare out the precision of solution concentration when improving the liquid of joining in marriage next time, and hinder the second liquid outflow when avoiding the filler to roll.

Optionally, a first flow sensor 29 for monitoring bubbles in the tube is arranged between the first liquid storage container 11 and the first blending container 14; the first flow sensor 29 is electrically connected with the first infusion pump 17, and the first flow sensor 29 is used for correspondingly controlling the first infusion pump 17 to stop working when monitoring bubbles; whether or not air bubbles are generated is detected by the first flow sensor 29 to avoid the first infusion pump 17 from entering a dead cycle of operation due to insufficient liquid in the first liquid storage container 11.

Optionally, a second flow sensor 28 for monitoring bubbles in the tube is provided between the second liquid storage container 12 and the first blending container 14; the second flow sensor 28 is electrically connected with the second infusion pump 18, and the second flow sensor 28 is used for correspondingly controlling the second infusion pump 18 to stop working when the bubbles are detected; the second flow sensor 28 detects the occurrence of air bubbles to avoid the second infusion pump 18 entering a dead cycle of operation due to insufficient liquid in the second liquid storage container 12.

Optionally, a third flow sensor 27 for monitoring bubbles in the tube is arranged between the first mixing container 14 and the third infusion pump 19; the third flow sensor 27 is electrically connected to the third infusion pump 19, and the third flow sensor 27 is used for controlling the third infusion pump 19 to stop working correspondingly when the bubbles are detected. The third flow sensor 27 detects the generation of air bubbles to prevent the third infusion pump 19 from entering a dead cycle of operation when the solution preparation apparatus is completely filled with the liquid.

Referring to fig. 1, 2, 6-8, optionally, the first blending container 14 comprises a first container top 141, a first container body 142 and a first container bottom 143 connected in sequence from top to bottom; first container body 142 is between first container top 141 and first container bottom 143; alternatively, the cross-sectional area of the first container body 142 is greater than the cross-sectional area of the first container top 141 and the first container bottom 143, respectively. By providing a larger cross-sectional area of the first container body 142 than the first container top 141, the amount of liquid remaining on the walls of the container is reduced and the mixing of the upper layer of liquid in the first mixing container 14 is facilitated. Under the same volume, when the radial distance of the container in the liquid flowing direction is gradually reduced, compared with the radial distance when the radial distance is increased or unchanged, the uniform mixing of the upper layer solution is more facilitated under the same vortex uniform mixing action.

Optionally, the second blending container 15 includes a second container top 151, a second container body 152, and a second container bottom 153 connected in sequence from top to bottom, and the second container body 152 is between the second container top 151 and the second container bottom 153. Optionally, the cross-sectional area of the second container body 152 is greater than the cross-sectional area of the second container top 151 and second container bottom 153, respectively. The cross-sectional area of the second container body 152 is larger than that of the top 151 of the second container, so that the residue of the liquid on the wall of the container can be reduced, and the uniform mixing of the upper layer liquid in the second uniform mixing container 15 is facilitated. Under the same volume, when the radial distance of the container in the liquid flowing direction is gradually reduced, compared with the radial distance when the radial distance is increased or unchanged, the uniform mixing of the upper layer solution is more facilitated under the same vortex uniform mixing action.

Optionally, the first container top 141 communicates with the second container bottom 153 via a connecting tube 16.

Optionally, the top tube 26 is disposed on the second vessel top 151; the top pipe 26 communicates with the second top 151 and is used for discharging the gas in the second kneading vessel 15.

Optionally, a second drainage channel 154 is provided on the second container bottom 153; a connecting pipe 16 for communicating the first blending container 14 with the second blending container 15 is arranged between the top 141 of the first container and the bottom 153 of the second container.

Optionally, at least one filler is disposed within the first blending container 14; by providing at least one filling in the first mixing vessel 14, the influence of deviations due to the vessel processing on the solution concentration can be reduced. Optionally, the filler is a plurality of bulbs.

Optionally, at least one filler is arranged in the second mixing container 15; by providing at least one filling in the second mixing vessel 15, the influence of deviations due to the vessel processing on the solution concentration can be reduced. Optionally, the filler is a plurality of bulbs.

Referring to fig. 1, optionally, a first magnetic stirrer 22 is disposed at the bottom of the first blending container 14, and at least one filler is disposed in the first blending container 14, where the filler is a first stirrer 24; the concentration deviation between the upper solution and the lower solution in the first kneading vessel 14 can be reduced by the first stirrer 24.

Referring to fig. 1, optionally, a second magnetic stirrer 23 is arranged at the bottom of the second blending container 15, and at least one filler is arranged in the second blending container 15, wherein the filler is a second stirrer 25; the concentration deviation between the upper layer solution and the lower layer solution in the second kneading vessel 15 can be reduced by the second stirrer 25.

Optionally, the top of top tube 26 is provided with a vent check 276 to prevent liquid from rushing out. The exhaust one-way mechanism 276 consists of a pressure sensor arranged above the position of the first sensor 20 and an electromagnetic valve, when the liquid level in the top pipe 26 is higher than the pressure sensor, the electromagnetic valve is closed, and the exhaust one-way mechanism 276 is closed; when the liquid level in the top pipe 26 is lower than the pressure sensor, the electromagnetic valve is opened, and the exhaust check mechanism 276 is opened. When the time for which the second infusion pump 18 injects the liquid into the liquid dispensing device exceeds the set time, it is described that the second liquid injection amount is too large and the air release check mechanism 276 is closed, and in addition, the air release check mechanism 276 is kept in an open state so that the liquid can be smoothly injected into the first kneading container 14 and the second kneading container 15. With this arrangement, the liquid in the solution preparation apparatus can be prevented from being ejected from the top pipe 26 due to the failure of the first sensor 20.

The embodiment further provides a solution preparation method suitable for the solution preparation device, which is used for further reducing the concentration deviation of the solution after the preparation of the washing solution, solving the problem of concentration accumulated error after the current washing solution is prepared for multiple times, and improving the precision of automatic liquid preparation of the washing solution of the existing multiple immunoassay analyzer. Referring to fig. 9, the solution preparing method includes:

s1: starting a solution preparation device; proceed to S2.

S2: the first infusion pump 17 delivers the first liquid in the first liquid storage container 11 to the first mixing container 14 through the first one-way mechanism 271, while the first one-way mechanism 271 is in a connected state, and the second one-way mechanism 272 and the third one-way mechanism 273 are in a closed state.

When the second sensor 21 monitors that the liquid level reaches the preset height and outputs a signal to the control unit, the control unit controls the first infusion pump 17 to stop working, and meanwhile, the first one-way mechanism 271, the second one-way mechanism 272, the third one-way mechanism 273 and the fourth one-way mechanism 274 are in a closed state; proceeding to S3; otherwise, the first infusion pump 17 continues to deliver the first fluid in the first fluid storage container 11 to the first mixing container 14. When the second sensor 21 detects that the liquid level exceeds the preset level, the control unit controls the fourth one-way mechanism 274 to open, communicates the N end and the C end of the waste washing three-way mechanism 275, and enables the third infusion pump 19 to work, so as to convey the first liquid into the waste liquid container 33 through the waste washing three-way mechanism 275 until the liquid level detected by the second sensor 21 reaches the preset level.

S3, the control unit controls the first infusion pump 17 to stop working, and at the same time, the control unit controls the second infusion pump 18 to convey the second liquid in the second liquid storage container 12 to the first blending container 14 through the second one-way mechanism 272 and the third one-way mechanism 273 respectively through the three-way structure 32, and meanwhile, the second one-way mechanism 272 and the third one-way mechanism 273 are in a communicated state, and the first one-way mechanism 271 is in a closed state;

the second liquid respectively through second liquid inflow channel B1 and second liquid inflow channel B2 get into first mixing container 14 in to form anticlockwise or clockwise vortex with original liquid in first mixing container 14, also be that original liquid forms anticlockwise or clockwise vortex under the traction of two strands of second liquid that inject in first mixing container 14, thereby make the inside liquid mixing of first mixing container 14 and the inside liquid mixing of second mixing container 15, at this moment, second sensor 21 can detect the liquid level signal.

When the first sensor 20 monitors that the liquid level reaches the preset height and outputs a signal to the control unit, the control unit controls the second infusion pump 18 to stop working, and meanwhile, the first one-way mechanism 271, the second one-way mechanism 272, the third one-way mechanism 273 and the fourth one-way mechanism 274 are in a closed state; proceeding to S4; otherwise, the second infusion pump 18 continues to deliver the second liquid from the second liquid reservoir 12 to the first blending container 14.

S4: the control unit controls the second infusion pump 18 to stop working, simultaneously outputs signals to the control unit through the first sensor 20 and the second sensor 21, controls the third infusion pump 19 and the fourth one-way mechanism 274 to be started in sequence, and discharges liquid in the solution preparation device into the third liquid storage container 13; at this time, the N terminal and the O terminal of the waste three-way mechanism 275 are also in an open state.

After the liquid in the solution preparation device is completely discharged, that is, after the liquid in the first blending container 14 and the second blending container 15 is completely discharged, the control unit controls the third infusion pump 19 to stop working, and at this time, the first one-way mechanism 271, the second one-way mechanism 272, the third one-way mechanism 273 and the fourth one-way mechanism 274 are in a closed state. Proceed to S5.

Referring to fig. 9, in an alternative of this embodiment, the solution preparing method further includes:

s5: repeating the steps S1-S3 to prepare a new round of liquid;

at this time, the first one-way mechanism 271, the second one-way mechanism 272, and the third one-way mechanism 273 are in the closed state, and the fourth one-way mechanism 274 is in the open state; meanwhile, the third liquid storage container 13, the first kneading container 14, and the second kneading container 15 each contain a liquid having been prepared, and the solution preparation in the solution preparation apparatus and the liquid replenishment in the third liquid storage container 13 are completed.

The solution preparation method adopts the steps S1-S5, and has the following advantages:

1. the solution can be automatically prepared;

2. the interference of bubbles on the injection amount of the first liquid can be reduced;

3. the interference of bubbles on the injection amount of the second liquid can be reduced;

4. the concentration difference of upper liquid and lower floor's liquid in reducible first mixing container 14, the concentration difference of upper liquid and the 15 lower floor's liquid of second mixing container in reducible first mixing container 14, and prevent to pollute the second liquid, and then can reduce the concentration difference of upper liquid and lower floor's liquid in the solution preparation device, can effectively reduce the solution concentration deviation after the preparation of configuration liquid.

Optionally, in step S3, the liquid enters the second mixing container 15, and the gas in the solution preparation device is exhausted through the top pipe 26.

Referring to fig. 9, in an alternative embodiment, before the "control unit controls the first infusion pump 17 to stop operating" in step S3, the control unit controls the first infusion pump 17 to pause operating until the liquid level in the first blending container 14 is not changed, so as to reduce the error of the injection amount of the first liquid; the method specifically comprises the following steps:

after the control unit controls the first infusion pump 17 to pause for a certain time, the second sensor 21 can still monitor that the liquid level reaches the preset height, and then the first infusion pump 17 is not started; otherwise, the first infusion pump 17 is started again until the second sensor 21 monitors that the liquid level reaches the preset height; for example, if the second sensor 21 fails to detect the liquid level signal after 20 seconds, the first infusion pump 17 is started again; when the first infusion pump 17 is restarted, the first check mechanism 271 is in a connected state, and the second check mechanism 272, the third check mechanism 273, and the fourth check mechanism 274 are in a closed state.

In an alternative of this embodiment, the delivery rate at which the first infusion pump 17 is restarted is less than the delivery rate at which the first infusion pump 17 is started for the first time to further reduce the error in the first liquid injection amount.

Referring to fig. 9, in an alternative embodiment, before the "control unit controls the second infusion pump 18 to stop operating" in step S4, the control unit controls the second infusion pump 18 to stop operating until the liquid level in the second blending container 15 is not changed, so as to reduce the error of the second liquid injection amount; the method specifically comprises the following steps:

after the control unit controls the second infusion pump 18 to pause for a certain time, the first sensor 20 can still monitor that the liquid level reaches the preset height, and then the second infusion pump 18 is not started; otherwise, the second infusion pump 18 is started again until the first sensor 20 detects that the liquid level reaches the preset height; for example, after 20 seconds, the first sensor 20 fails to detect the level signal, and the second infusion pump 18 is restarted; when the second infusion pump 18 is started again, the second check mechanism 272 and the third check mechanism 273 are in a communication state, and the first check mechanism 271 and the fourth check mechanism 274 are in a closed state.

In an alternative of this embodiment, the delivery rate at which the second infusion pump 18 is restarted is less than the delivery rate at which the second infusion pump 18 was first started to further reduce errors in the second liquid injection amount.

In an alternative embodiment of the present invention, when the control unit controls the second infusion pump 18 to stop working, the first one-way mechanism 271, the second one-way mechanism 272, the third one-way mechanism 273, and the fourth one-way mechanism 274 are in the closed state, and the first magnetic stirrer 22 disposed in the first blending container 14 and the second magnetic stirrer 23 disposed in the second blending container 15 are simultaneously started to blend the solution in the solution preparation apparatus.

Optionally, a first flow sensor 29 for monitoring bubbles in the tube is arranged between the first liquid storage container 11 and the first blending container 14; the first flow sensor 29 is electrically connected with the first infusion pump 17, and the first flow sensor 29 is used for correspondingly controlling the first infusion pump 17 to stop working when monitoring bubbles; whether or not air bubbles are generated is detected by the first flow sensor 29 to avoid the first infusion pump 17 from entering a dead cycle of operation due to insufficient liquid in the first liquid storage container 11. The air bubbles referred to herein are air bubbles generated due to insufficient liquid level in the corresponding line due to insufficient amount of liquid in the first liquid storage container 11, the second liquid storage container 12, or the first kneading container 14.

In an alternative embodiment of the present invention, in step S4, the "draining of the liquid in the solution preparation apparatus" includes: the liquid level in the solution preparation device is lower than the second sensor 21, so that the signal of the second sensor 21 is interrupted, and then no induction liquid flows through the third flow sensor 27 for a fixed time; wherein the third flow sensor 27 is disposed between the first kneading container 14 and the third infusion pump 19; alternatively, the third flow sensor 27 should be free of inductive fluid flow for 8s-20s, e.g., 10s, 15s, etc.

In an alternative embodiment, in step S4, the "solution preparing apparatus is drained" may be as follows: the solution preparation device is stopped by the second sensor 21 when the liquid level is lower than the second sensor 21, and then the third infusion pump 19 is stopped, and the fourth one-way mechanism 274 and the third infusion pump 19 are stopped when the specified time elapses, and the cycle is ended.

In an alternative embodiment, step S1 includes, when the liquid level in the third liquid storage container 13 monitored by the third sensor 30 is lower than the preset minimum height, starting the solution preparation device to prepare the liquid according to the above steps; otherwise, the solution preparation device does not start the solution preparation.

When the liquid level in the third liquid storage container 13 monitored by the third sensor 30 is not lower than the preset liquid height, the solution preparation device does not start liquid preparation; otherwise, the solution preparation device starts to prepare the solution. Wherein the preset liquid height is higher than the preset lowest height. For example, when the liquid level in the third liquid storage container 13, which is monitored by the third sensor 30, reaches the preset liquid level, the third sensor 30 sends a signal to the control unit, and the control unit does not start the solution preparation device; if the liquid level in the third liquid storage container 13 monitored by the third sensor 30 does not reach the preset liquid level, the third sensor 30 sends a signal to the control unit, and the control unit starts the solution preparation device.

In an alternative of this embodiment, when a sudden termination, such as a power failure, occurs during the solution preparation process, the first one-way mechanism 271, the second one-way mechanism 272 and the third one-way mechanism 273 are turned off, and the first infusion pump 17 and the second infusion pump 18 are turned off;

then, the fourth one-way mechanism 274 is opened, the N end and the C end of the waste washing three-way mechanism 275 are communicated, the third infusion pump 19 is enabled to work, the liquid in the first mixing container 14 and the second mixing container 15 is conveyed into the waste liquid container 33 through the waste washing three-way mechanism 275 until the liquid level in the solution preparation device is lower than that of the second sensor 21, and no induction liquid flows through the third flow sensor 27 within a fixed time; the third flow sensor 27 is arranged between the first mixing container 14 and the third infusion pump 19, and the waste washing three-way mechanism 275 comprises an N end communicated with the third infusion pump 19, a C end communicated with the waste liquid container 33 and an O end communicated with the third liquid storage container 13; alternatively, the third flow sensor 27 should be free of inductive fluid flow for 8s-20s, e.g., 10s, 15s, etc.

Then, the control unit controls the third infusion pump 19 to stop working, closes the fourth one-way mechanism 274, communicates the N end and the O end of the waste washing three-way mechanism 275, and then starts the solution preparing device.

In the solution preparation method of this embodiment, a corresponding control method of "sudden termination occurs in the solution preparation process" is provided, so that the solution preparation concentration deviation caused by unknown injection amounts of the first liquid, the second liquid and the liquid or other situations (for example, ununiform mixing) during the solution preparation in the solution preparation device in a sudden situation can be reduced. After an emergency occurs, the liquid in the first mixing container 14 and the second mixing container 15 is conveyed into the waste liquid container, and then the liquid in the first mixing container 14 and the second mixing container 15 is prepared again, so that the automatic liquid preparation process is realized.

The solution preparing method provided by the embodiment is suitable for the solution preparing device, and the technical features of the solution preparing device disclosed above are also suitable for the solution preparing method, and the technical features of the solution preparing device disclosed above are not described repeatedly. The solution preparation method in the present embodiment has the advantages of the solution preparation device, and the advantages of the solution preparation device disclosed above are not described repeatedly herein.

The embodiment also provides an in vitro diagnostic and analytical device, which comprises the solution preparation device or the solution preparation method; the in-vitro diagnostic and analytical device further comprises a control unit and a detection device. A third liquid storage container 13 of the solution preparation device provides washing liquid for the detection device; the solution preparation device is electrically connected with the control unit. The detection device can realize the processes of sample moving, sample reaction, sample detection and sample discarding; the control unit can control the operation of the whole in-vitro diagnosis and analysis equipment; the third liquid storage container 13 provides washing liquid for the sample reaction and/or the sample detection process; the third liquid storage container can send a signal to the control unit, and the control unit controls the solution preparation device to prepare the washing solution, so that the process of preparing the washing solution in the solution preparation device is influenced by the washing solution used by the equipment.

The in-vitro diagnostic and analysis apparatus provided by this embodiment includes the solution preparation device, adopts the solution preparation method disclosed above, and the technical features of the solution preparation device and the solution preparation method disclosed above are also applicable to the in-vitro diagnostic and analysis apparatus, and the technical features of the solution preparation device and the solution preparation method disclosed above are not described repeatedly. The in vitro diagnostic and analytical apparatus of the present embodiment has the advantages of the solution preparing apparatus and the solution preparing method, and the advantages of the solution preparing apparatus and the solution preparing method disclosed above are not repeated herein.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The solution preparation device is characterized by comprising a first liquid storage container (11), a second liquid storage container (12), a first blending container (14) and a second blending container (15);

the top of the second blending container (15) is communicated with a top pipe (26), and the cross sectional area of the top pipe (26) is smaller than that of the second blending container (15) along the horizontal direction;

the second blending container (15) is arranged at the top of the first blending container (14), and the second blending container (15) is communicated with the first blending container (14) through a connecting pipe (16); the cross-sectional area of the second mixing container (15) in the horizontal direction and the cross-sectional area of the first mixing container (14) are both larger than the cross-sectional area of the connecting pipe (16);

a second sensor (21) for detecting the liquid level in the connecting pipe (16) is arranged on the connecting pipe (16); a first infusion pump (17) is arranged between the first liquid storage container (11) and the first blending container (14); the first infusion pump (17) is used for conveying the first liquid in the first liquid storage container (11) to the first blending container (14); the first infusion pump (17) is electrically connected with the second sensor (21), when the second sensor (21) monitors that the liquid level in the connecting pipe (16) reaches a preset height, the second sensor (21) outputs a corresponding signal to the control unit, and the control unit controls the first infusion pump (17) to stop working;

the top pipe (26) is provided with a first sensor (20) for detecting the liquid level in the top pipe (26); a second infusion pump (18) is arranged between the second liquid storage container (12) and the first blending container (14); the second infusion pump (18) is used for conveying the second liquid in the second liquid storage container (12) to the first blending container (14) and enabling the liquid in the first blending container (14) to reach the second blending container (15) through the connecting pipe (16); the second infusion pump (18) is electrically connected with the first sensor (20), when the first sensor (20) monitors that the liquid level in the top pipe (26) reaches a preset height, the first sensor (20) outputs a corresponding signal to the control unit, and the control unit controls the second infusion pump (18) to stop working;

the bottom of the first blending container (14) is at least provided with a first liquid inflow channel A, a second liquid inflow channel B1, a second liquid inflow channel B2 and a liquid drainage channel C;

the first infusion pump (17) is communicated with the first liquid inflow channel A, and the second infusion pump (18) is respectively communicated with the second liquid inflow channel B1 and the second liquid inflow channel B2;

the projections of the axial direction of the second liquid inflow passage B1, the axial direction of the second liquid inflow passage B2 and the axial direction of the first kneading container (14) on any spatial plane are not parallel to each other.

2. The solution preparation device according to claim 1, wherein a three-way structure (32) is arranged between the second infusion pump (18) and the first mixing container (14); a first end of the three-way structure (32) is communicated with the second infusion pump (18), a second end of the three-way structure (32) is communicated with the second liquid inflow channel B1 through a second one-way mechanism (272), and a third end of the three-way structure (32) is communicated with the second liquid inflow channel B2 through a third one-way mechanism (273); the second one-way mechanism (272) and the third one-way mechanism (273) are respectively used for preventing the liquid in the first blending container (14) from flowing out;

the solution preparation device also comprises a third liquid storage container (13), and the third liquid storage container (13) is communicated with the liquid drainage channel C;

the third liquid storage container (13) is provided with a third sensor (30) for monitoring the liquid level in the third liquid storage container (13);

a third infusion pump (19) is arranged between the third liquid storage container (13) and the first blending container (14); the third infusion pump (19) is used for conveying the liquid in the first blending container (14) to the third liquid storage container (13); the third transfer pump (19) respectively with first sensor (20), second sensor (21) and third sensor (30) electricity is connected, works as first sensor (20) monitoring liquid level in push pipe (26) reaches and predetermines the height, second sensor (21) monitoring liquid level in connecting pipe (16) reaches and predetermines the height and third sensor (30) monitoring liquid level in third liquid storage container (13) is not higher than when predetermineeing minimum height output corresponding signal to the control unit, by the control unit control third transfer pump (19) begin work.

3. The solution preparation apparatus according to claim 2, wherein a first one-way mechanism (271) for preventing the liquid in the first kneading container (14) from flowing out is provided in a pipeline between the first infusion pump (17) and the first kneading container (14);

a fourth one-way mechanism (274) for enabling the liquid in the first blending container (14) to flow out in one way is arranged on a pipeline between the third infusion pump (19) and the first blending container (14);

the first one-way mechanism (271), the second one-way mechanism (272), the third one-way mechanism (273) and the fourth one-way mechanism (274) are all one-way solenoid valves;

the first one-way mechanism (271) is electrically connected with the second sensor (21);

the second one-way mechanism (272) and the third one-way mechanism (273) are electrically connected to the first sensor (20), respectively;

the fourth one-way mechanism (274) is electrically connected with the first sensor (20), the second sensor (21) and the third sensor (30), respectively;

the bottom of the inner surface of the first blending container (14) is in a conical surface shape; the liquid discharge channel C is arranged at the lowest part of the bottom of the inner surface of the first blending container (14);

the first liquid inflow channel A is provided with a pointed one-way structure for preventing the liquid in the first blending container (14) from flowing out;

a first flow sensor (29) for monitoring bubbles in the pipe is arranged between the first liquid storage container (11) and the first blending container (14); the first flow sensor (29) is electrically connected with the first infusion pump (17), and the first flow sensor (29) is used for correspondingly controlling the first infusion pump (17) to stop working when monitoring bubbles;

a second flow sensor (28) for monitoring bubbles in the pipe is arranged between the second liquid storage container (12) and the first blending container (14); the second flow sensor (28) is electrically connected with the second infusion pump (18), and the second flow sensor (28) is used for correspondingly controlling the second infusion pump (18) to stop working when monitoring air bubbles;

a third flow sensor (27) for monitoring bubbles in the tube is arranged between the first mixing container (14) and the third infusion pump (19); the third flow sensor (27) is electrically connected with the third infusion pump (19), and the third flow sensor (27) is used for correspondingly controlling the third infusion pump (19) to stop working when monitoring bubbles;

the first blending container (14) comprises a first container top part (141), a first container body (142) and a first container bottom part (143) which are sequentially connected from top to bottom; the first container body (142) has a cross-sectional area that is greater than the cross-sectional areas of the first container top (141) and the first container bottom (143), respectively;

the second blending container (15) comprises a second container top (151), a second container body (152) and a second container bottom (153) which are sequentially connected from top to bottom, and the cross sectional area of the second container body (152) is respectively larger than that of the second container top (151) and that of the second container bottom (153);

the first container top (141) and the second container bottom (153) are communicated through the connecting pipe (16);

the top pipe (26) is arranged on the top part (151) of the second container;

a first magnetic stirrer (22) is arranged at the bottom of the first blending container (14), and at least one first stirrer (24) is arranged in the first blending container (14);

a second magnetic stirrer (23) is arranged at the bottom of the second blending container (15), and at least one second stirrer (25) is arranged in the second blending container (15);

the top of the top pipe (26) is provided with an exhaust one-way mechanism (276) for preventing liquid from rushing out.

4. A solution preparing method suitable for the solution preparing apparatus according to claim 2, wherein a fourth one-way mechanism (274) for causing the liquid in the first kneading container (14) to flow out in one way is provided on a pipeline between the third infusion pump (19) and the first kneading container (14); the method comprises the following steps:

s1: starting a solution preparation device;

s2: the first liquid in the first liquid storage container (11) is conveyed into the first blending container (14) through the first one-way mechanism (271) by the first liquid conveying pump (17), meanwhile, the first one-way mechanism (271) is in a communicated state, and the second one-way mechanism (272) and the third one-way mechanism (273) are in a closed state;

when the second sensor (21) monitors that the liquid level reaches a preset height, the second sensor outputs a signal to the control unit, the control unit controls the first infusion pump (17) to stop working, and meanwhile, the first one-way mechanism (271), the second one-way mechanism (272), the third one-way mechanism (273) and the fourth one-way mechanism (274) are in a closed state; otherwise, the first infusion pump (17) continues to convey the first liquid in the first liquid storage container (11) to the first blending container (14);

s3, the control unit controls the first infusion pump (17) to stop working, and at the same time, the control unit controls the second infusion pump (18) to convey the second liquid in the second liquid storage container (12) into the first blending container (14) through the second one-way mechanism (272) and the third one-way mechanism (273) respectively through the three-way structure (32), and meanwhile, the second one-way mechanism (272) and the third one-way mechanism (273) are in a communicated state, and the first one-way mechanism (271) is in a closed state;

the second liquid enters the first blending container (14) through a second liquid inflow channel B1 and a second liquid inflow channel B2 respectively and forms a counterclockwise or clockwise vortex with the original liquid in the first blending container (14), so that the liquid in the first blending container (14) is mixed with the liquid in the second blending container (15), and at the moment, the second sensor (21) can detect a liquid level signal;

when the first sensor (20) monitors that the liquid level reaches a preset height, the first sensor outputs a signal to the control unit, the control unit controls the second infusion pump (18) to stop working, and meanwhile, the first one-way mechanism (271), the second one-way mechanism (272), the third one-way mechanism (273) and the fourth one-way mechanism (274) are in a closed state; otherwise, the second infusion pump (18) continues to convey the second liquid in the second liquid storage container (12) to the first blending container (14);

s4: the control unit controls the second infusion pump (18) to stop working, simultaneously outputs signals to the control unit through the first sensor (20) and the second sensor (21), controls the third infusion pump (19) and the fourth one-way mechanism (274) to be started in sequence, and discharges liquid in the solution preparation device into the third liquid storage container (13);

after the liquid in the solution preparation device is completely discharged, the control unit controls the third infusion pump (19) to stop working, and at the moment, the first one-way mechanism (271), the second one-way mechanism (272), the third one-way mechanism (273) and the fourth one-way mechanism (274) are in a closed state.

5. The solution preparing method according to claim 4, wherein the step S3, before the step of controlling the first infusion pump (17) to stop operating, the step of controlling the first infusion pump (17) to stop operating until the liquid level in the first mixing container (14) is not changed by the control unit, comprises:

after the control unit controls the first infusion pump (17) to pause for a certain time, the second sensor (21) can still monitor that the liquid level reaches the preset height, and then the first infusion pump (17) is not started; otherwise, the first infusion pump (17) is started again until the second sensor (21) monitors that the liquid level reaches the preset height; when the first infusion pump (17) is started again, the first one-way mechanism (271) is in a communication state, and the second one-way mechanism (272), the third one-way mechanism (273) and the fourth one-way mechanism (274) are in a closing state;

and/or the presence of a gas in the gas,

in the step S4, before the control unit controls the second infusion pump (18) to stop working, the control unit controls the second infusion pump (18) to pause working until the liquid level in the second blending container (15) is unchanged, and the method specifically includes:

after the control unit controls the second infusion pump (18) to pause for a certain time, the first sensor (20) can still monitor that the liquid level reaches the preset height, and then the second infusion pump (18) is not started; otherwise, the second infusion pump (18) is started again until the first sensor (20) detects that the liquid level reaches the preset height; when the second infusion pump (18) is restarted, the second one-way mechanism (272) and the third one-way mechanism (273) are in a connected state, and the first one-way mechanism (271) and the fourth one-way mechanism (274) are in a closed state.

6. The solution preparation method according to claim 5, wherein a first magnetic stirrer (22) is arranged at the bottom of the first mixing container (14), and at least one first stirrer (24) is arranged in the first mixing container (14); a second magnetic stirrer (23) is arranged at the bottom of the second blending container (15), and at least one second stirrer (25) is arranged in the second blending container (15);

the delivery speed for restarting the first infusion pump (17) is less than the delivery speed for starting the first infusion pump (17) for the first time;

the delivery rate at which the second infusion pump (18) is restarted is less than the delivery rate at which the second infusion pump (18) was first started;

when the second infusion pump (18) is controlled by the control unit to stop working, a first magnetic stirrer (22) arranged in the first blending container (14) and a second magnetic stirrer (23) arranged in the second blending container (15) are started at the same time, and the solution in the blending solution preparation device is mixed.

7. The solution preparation method according to claim 4, further comprising:

s5: repeating the steps S1-S3 to prepare a new round of liquid;

the first one-way mechanism (271), the second one-way mechanism (272) and the third one-way mechanism (273) are in a closed state, and the fourth one-way mechanism (274) is in an open state; meanwhile, the third liquid storage container (13), the first blending container (14) and the second blending container (15) are filled with prepared liquid, and the solution preparation in the solution preparation device and the liquid supplement in the third liquid storage container (13) are completed;

preferably, in step S3, the liquid is introduced into the second kneading vessel (15), and the gas in the solution preparation apparatus is discharged through the top pipe (26).

8. The solution preparing method according to claim 4, wherein the step S4 of discharging the liquid in the solution preparing apparatus includes: the liquid level in the solution preparation device is lower than the second sensor (21) so as to interrupt the signal of the second sensor (21), and then no induction liquid flows through the third flow sensor (27) within a fixed time; wherein a third flow sensor (27) is arranged between the first mixing container (14) and the third infusion pump (19); or, the liquid level in the solution preparation device is lower than the second sensor (21) to interrupt the signal of the second sensor (21), then the closing time of the third infusion pump (19) is delayed, and when the specified time is up, the fourth one-way mechanism (274) and the third infusion pump (19) are closed;

and/or the presence of a gas in the gas,

step S1 includes that when the liquid level in the third liquid storage container (13) monitored by the third sensor (30) is lower than the preset lowest height, the solution preparation device starts to prepare the liquid, otherwise, the solution preparation device does not start to prepare the liquid; when the liquid level in the third liquid storage container (13) monitored by the third sensor (30) is not lower than the preset liquid height, the solution preparation device does not start liquid preparation, otherwise, the solution preparation device starts liquid preparation; wherein the preset liquid height is higher than the preset lowest height.

9. The solution preparing method according to any one of claims 4 to 8, wherein when a sudden termination occurs during the solution preparing process, the first one-way mechanism (271), the second one-way mechanism (272) and the third one-way mechanism (273) are turned off, and the first infusion pump (17) and the second infusion pump (18) are turned off;

then, a fourth one-way mechanism (274) is opened, the N end and the C end of the waste washing three-way mechanism (275) are communicated, a third infusion pump (19) is enabled to work, liquid in the first mixing container (14) and the second mixing container (15) is conveyed into a waste liquid container (33) through the waste washing three-way mechanism (275), and no induction liquid flows through the third flow sensor (27) within a fixed time until the liquid level in the solution preparation device is lower than that of the second sensor (21); the third flow sensor (27) is arranged between the first blending container (14) and the third infusion pump (19), and the waste washing three-way mechanism (275) comprises an N end communicated with the third infusion pump (19), a C end communicated with the waste liquid container (33) and an O end communicated with the third liquid storage container (13);

and then, the control unit controls the third infusion pump (19) to stop working, closes the fourth one-way mechanism (274), communicates the N end and the O end of the waste washing three-way mechanism (275), and then starts the solution preparation device.

10. An in vitro diagnostic assay device comprising the solution formulating device according to any one of claims 1 to 3 or using the solution formulating method according to any one of claims 4 to 9, further comprising a control unit and a detection device;

a third liquid storage container (13) of the solution preparation device provides washing liquid for the detection device; the solution preparation device is electrically connected with the control unit.