CN113070006A - Avermectin micro-droplet preparation device and method based on flow focusing technology - Google Patents
Avermectin micro-droplet preparation device and method based on flow focusing technology Download PDFInfo
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- CN113070006A CN113070006A CN202110389399.7A CN202110389399A CN113070006A CN 113070006 A CN113070006 A CN 113070006A CN 202110389399 A CN202110389399 A CN 202110389399A CN 113070006 A CN113070006 A CN 113070006A
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- 239000005660 Abamectin Substances 0.000 title claims abstract description 57
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- 238000005516 engineering process Methods 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims abstract description 22
- 239000007788 liquid Substances 0.000 claims abstract description 25
- 238000002347 injection Methods 0.000 claims abstract description 17
- 239000007924 injection Substances 0.000 claims abstract description 17
- 238000004321 preservation Methods 0.000 claims abstract description 6
- 238000009833 condensation Methods 0.000 claims abstract description 5
- 230000005494 condensation Effects 0.000 claims abstract description 5
- 239000000243 solution Substances 0.000 claims description 34
- 230000002572 peristaltic effect Effects 0.000 claims description 27
- 238000010438 heat treatment Methods 0.000 claims description 24
- 108010010803 Gelatin Proteins 0.000 claims description 19
- 239000008273 gelatin Substances 0.000 claims description 19
- 229920000159 gelatin Polymers 0.000 claims description 19
- 235000019322 gelatine Nutrition 0.000 claims description 19
- 235000011852 gelatine desserts Nutrition 0.000 claims description 19
- 229950008167 abamectin Drugs 0.000 claims description 13
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 claims description 12
- 238000009413 insulation Methods 0.000 claims description 8
- 239000000284 extract Substances 0.000 claims description 5
- VTNQPKFIQCLBDU-UHFFFAOYSA-N Acetochlor Chemical compound CCOCN(C(=O)CCl)C1=C(C)C=CC=C1CC VTNQPKFIQCLBDU-UHFFFAOYSA-N 0.000 claims description 3
- 239000005730 Azoxystrobin Substances 0.000 claims description 3
- 229920001661 Chitosan Polymers 0.000 claims description 3
- 239000005562 Glyphosate Substances 0.000 claims description 3
- WFDXOXNFNRHQEC-GHRIWEEISA-N azoxystrobin Chemical compound CO\C=C(\C(=O)OC)C1=CC=CC=C1OC1=CC(OC=2C(=CC=CC=2)C#N)=NC=N1 WFDXOXNFNRHQEC-GHRIWEEISA-N 0.000 claims description 3
- XDDAORKBJWWYJS-UHFFFAOYSA-N glyphosate Chemical compound OC(=O)CNCP(O)(O)=O XDDAORKBJWWYJS-UHFFFAOYSA-N 0.000 claims description 3
- 229940097068 glyphosate Drugs 0.000 claims description 3
- 238000010030 laminating Methods 0.000 claims description 3
- 229940057995 liquid paraffin Drugs 0.000 claims description 3
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 3
- 229920002401 polyacrylamide Polymers 0.000 claims description 3
- 238000005189 flocculation Methods 0.000 claims description 2
- 230000016615 flocculation Effects 0.000 claims description 2
- 239000003292 glue Substances 0.000 claims 1
- 239000003094 microcapsule Substances 0.000 abstract description 22
- 239000002689 soil Substances 0.000 abstract description 7
- 238000009776 industrial production Methods 0.000 abstract description 5
- 230000000361 pesticidal effect Effects 0.000 abstract description 2
- 239000002245 particle Substances 0.000 description 8
- 230000000857 drug effect Effects 0.000 description 5
- 239000000575 pesticide Substances 0.000 description 5
- 238000012695 Interfacial polymerization Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- -1 hexadecane cyclic lactone Chemical class 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 238000002161 passivation Methods 0.000 description 3
- 241000238631 Hexapoda Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000005354 coacervation Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000004495 emulsifiable concentrate Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- 239000004563 wettable powder Substances 0.000 description 2
- 241001468227 Streptomyces avermitilis Species 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 230000000895 acaricidal effect Effects 0.000 description 1
- 239000000642 acaricide Substances 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- DCAYPVUWAIABOU-UHFFFAOYSA-N alpha-n-hexadecene Natural products CCCCCCCCCCCCCCCC DCAYPVUWAIABOU-UHFFFAOYSA-N 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000003311 flocculating effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000003578 releasing effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
- A01N25/28—Microcapsules or nanocapsules
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Environmental Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Agronomy & Crop Science (AREA)
- Dispersion Chemistry (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
The invention discloses an avermectin micro-droplet preparation device and method based on a flow focusing technology, and the device comprises a heat preservation box, a feeding tank, an outer needle head, an inner needle head, a cavity chamber, an injection pump and a condensation pipe, wherein the feeding tank is arranged in the heat preservation box, the inner needle head is embedded into the outer needle head, a driving liquid is filled in the cavity chamber, a driving phase inlet is arranged on the side surface of the cavity chamber, a driving phase outlet is arranged at the central position of the bottom of the cavity chamber, the feeding tank is connected with the outer needle head through a pipeline, the liquid outlet end of the injection pump is communicated and connected with the upper end of the inner needle head through a pipeline, the flow focusing technology is applied to the preparation of avermectin microcapsules, the problem that the avermectin meets soil and is passivated quickly to reduce the pesticide effect and the stability is solved, the prepared avermectin microcapsules have good slow-; simple structure, convenient operation, obviously reduces the preparation cost of the microcapsule and is suitable for industrial production.
Description
Technical Field
The invention belongs to the technical field of pesticide microcapsule preparation, and particularly relates to an avermectin micro-droplet preparation device and method based on a flow focusing technology.
Background
The avermectin is a hexadecane cyclic lactone biological medicine extracted from the metabolite fermented by streptomyces avermitilis. The abamectin has direct contact killing effect on predatory insects and parasitic natural enemies, but has little damage to beneficial insects because of little residue on the surface of the plant; the soil is absorbed by soil, cannot move and is decomposed by microorganisms, so that the soil has no accumulation effect in the environment; the abamectin compound is widely applied to control of parasites and about 80 crop pests, is an excellent broad-spectrum insecticide and acaricide, is one of the most potential biological pesticides at present, but abamectin is unstable in water and is easy to decompose under ultraviolet light.
Nowadays, abamectin has been presented in the forms of suspending agent, wettable powder, microcapsule, emulsifiable concentrate, etc., but considering the cost and industrial production, the emulsifiable concentrate is still the main stream of the market. However, most of the formulations of the emulsifiable solutions are surfactants, so that the content of active ingredients is low and the drug effect is poor; although the use amount of the organic solvent can be greatly reduced by the suspending agent and the wettable powder, the problem of abamectin stability cannot be solved. Therefore, the microcapsule is an effective way for improving the use efficiency of the abamectin.
At present, the abamectin microcapsules are prepared by an interfacial polymerization method, a complex coacervation method, an emulsification-solvent volatilization method and the like. Statistically, about 90% of the current commercial pesticide microcapsule formulations use the interfacial polymerization method.
The interfacial polymerization method has the advantages of simple process, high microencapsulation efficiency and low equipment cost. It has the advantages of commercial production without considering material adaptability and fine production, but the method is not suitable for preparing pesticides containing amino, hydroxyl and acid sensitivity, which are more abundant, for example: the avermectin contains primary and secondary hydroxyl groups. If the interfacial polymerization method is still used, other reactive monomers need to be added, the controlled variable factors are increased, and the preparation cost is increased.
For preparing pesticides containing amino, hydroxyl and acid sensitivity, a complex coacervation method is used, so that the production cost is high, the wrapping efficiency is low, and the method is not suitable for commercial production.
Emulsion-solvent evaporation, which requires consumption of a large amount of organic solvent, has adverse effects on both environment and human body, requires a stirring or ultrasonic method for reducing the particle size, and cannot precisely control the particle size.
Disclosure of Invention
The invention provides an avermectin micro-droplet preparation device and method based on a flow focusing technology, and aims to solve the problems in the background technology.
In order to achieve the purpose, the invention adopts the technical scheme that: an avermectin micro-droplet preparation device based on a flow focusing technology comprises an insulation can, a feeding tank, an outer needle, an inner needle, a cavity, an injection pump and a condensation pipe, wherein the feeding tank is arranged in the insulation can, the inner needle is embedded in the outer needle, the outer needle head is fixed in the cavity chamber through the rubber plug, the cavity chamber is filled with driving liquid, the side surface of the cavity chamber is provided with a driving phase inlet, the central position of the bottom of the cavity chamber is provided with a driving phase outlet, the feeding tank and the outer needle head are connected through a pipeline, a peristaltic pump I and a buffer bottle I are sequentially arranged on a pipeline from the feeding tank to the outer needle head direction, the liquid outlet end of the injection pump is communicated and connected with the upper end of the inner needle head through the pipeline, the condenser pipe is arranged right below the driving phase outlet, the condenser pipe is connected with the driving phase inlet through a pipeline, and a peristaltic pump II and a buffer bottle II are sequentially arranged on the pipeline from the condensation pipe to the driving phase inlet direction.
Preferably, the first peristaltic pump and the first buffer bottle are arranged in the incubator.
Preferably, the inner needle is embedded into the outer needle, the inner needle and the outer needle are coaxially arranged, and the lower end of the inner needle exceeds the lower end of the outer needle by 0.2 mm.
Preferably, the charging tank includes outer cavity, interior chamber, temperature sensor, heating plate one, heating plate two and fixed disc, interior chamber embedding exocoel is indoor, temperature sensor and interior chamber upper end center fastening connection, and insert the intracavity, heating plate one and the laminating of outer cavity outer wall, heating plate two locates outer cavity bottom, and by fixed disc fastening connection, the indoor gelatin solution of packing into of intracavity.
Preferably, the heating sheet is coiled into a cylindrical barrel type to cover the outer wall of the outer cavity.
Preferably, the gelatin solution is flocculating, for example: PLGA, gelatin, chitosan, or polyacrylamide.
Preferably, the driving liquid adopts liquid paraffin; an oily core solution is provided in the syringe pump, for example: abamectin, azoxystrobin, acetochlor or glyphosate.
A method for preparing avermectin micro-droplets based on a flow focusing technology specifically comprises the following steps,
step S1: the first heating sheet and the second heating sheet are electrically heated and are kept at a constant temperature by the heat insulation box;
step S2: when the temperature sensor reaches the calibration temperature, the injection pump, the peristaltic pump I and the peristaltic pump II are started simultaneously, the injection pump injects the oily core solution into the inner needle head, and then the oily core solution flows out from the bottom; the peristaltic pump I extracts the gelatin solution from the inner chamber, injects the gelatin solution into the buffer bottle I, enters an annular cavity formed between the outer needle head and the inner needle head, and then flows out from the bottom; the peristaltic pump II extracts the driving liquid condensed by the condensing tube from the condensing tube, injects the driving liquid into the buffer bottle II, enters the driving phase inlet and then flows to the driving phase outlet;
step S3: the driving liquid flowing to the driving phase outlet provides constraint force for micro-liquid drop phases formed by oily inner core solution flowing out from the bottom of the inner needle head and gelatin solution flowing out from an annular cavity formed between the outer needle head and the inner needle head to form a stable cone, the micro-liquid drop phases further penetrate through the driving phase outlet to form a jet flow column, and the jet flow column is finally broken into micro-liquid drops in an external environment due to unbalanced disturbance of surface propagation.
The beneficial effect of adopting above technical scheme is:
1. this avermectin micro-droplet preparation facilities based on flow focusing technique applies the flow focusing technique to the preparation of avermectin microcapsule, has solved avermectin and has met quick passivation of soil and reduce the drug effect problem and the stability problem, and the avermectin microcapsule who prepares has good slowly-releasing effect and high embedding rate, has improved the utilization ratio of avermectin.
2. The avermectin micro-droplet preparation device based on the flow focusing technology is simple in structure and convenient to operate, obviously reduces the preparation cost of the microcapsule, and is suitable for industrial production.
3. The avermectin microcapsule prepared by the avermectin micro-droplet preparation method based on the flow focusing technology has good product dispersibility, and solves the problem of non-uniform drug action.
The prepared avermectin microcapsule has the advantages that the particle size of the product is accurate and controllable, the flow rates of an avermectin solution, a gelatin solution and a driving liquid are indirectly controlled by controlling an injection pump, a peristaltic pump I and a peristaltic pump II, and the stability of a cone-jet flow mode is controlled, so that the particle size of micro-droplets formed by jet flow crushing caused by unstable propagation along disturbance of the jet flow surface is controlled, the microcapsule product with proper particle size is controlled, and the full play of drug effect is facilitated.
Drawings
FIG. 1 is a schematic structural diagram of an avermectin micro-droplet preparation device based on a flow focusing technology;
FIG. 2 is an enlarged view of a portion of FIG. 1 at position A;
wherein:
1. a heat preservation box; 2. a charging tank; 3. an outer needle; 4. an inner needle head; 5. a hollow chamber; 6. an injection pump; 7. a condenser tube;
2-3, a peristaltic pump I; 2-4, a buffer bottle I;
20. an outer chamber; 21. an inner chamber; 22. a temperature sensor; 23. heating a first heating plate; 24. a second heating plate; 25. fixing the disc;
50. a drive phase inlet; 51. a drive phase outlet;
7-1, a peristaltic pump II; 7-2 and a second buffer bottle.
Detailed Description
The following detailed description of the embodiments of the present invention will be given with reference to the accompanying drawings for a purpose of helping those skilled in the art to more fully, accurately and deeply understand the concept and technical solution of the present invention and to facilitate its implementation.
As shown in fig. 1 to 2, the invention is an avermectin micro-droplet preparation device and method based on a flow focusing technology, the flow focusing technology is applied to the preparation of avermectin microcapsules, the problems of reduction of drug effect and stability caused by rapid passivation of avermectin in soil are solved, and the prepared avermectin microcapsules have good slow release effect and high embedding rate, so that the utilization rate of the avermectin is improved; simple structure, convenient operation, obviously reduces the preparation cost of the microcapsule and is suitable for industrial production.
Specifically speaking, as shown in fig. 1 to 2, an avermectin micro-droplet preparation device based on flow focusing technology comprises an insulation can 1, a feeding tank 2, an outer needle 3, an inner needle 4, a cavity 5, an injection pump 6 and a condensation pipe 7, wherein the feeding tank 2 is arranged in the insulation can 1, the inner needle 4 is embedded into the outer needle 3, the outer needle 3 is fixed in the cavity 5 through a rubber plug, the cavity 5 is filled with a driving liquid, a driving phase inlet 50 is arranged on the side surface of the cavity 5, a driving phase outlet 51 is arranged at the central position of the bottom of the cavity 5, the feeding tank 2 is connected with the outer needle 3 through a pipeline, a peristaltic pump 2-3 and a buffer bottle 2-4 are sequentially arranged on the pipeline from the feeding tank 2 to the outer needle 3, the liquid outlet end of the injection pump 6 is communicated and connected with the upper end of the inner needle 4 through a pipeline, the condenser pipe 7 is arranged right below the driving phase outlet 51, the condenser pipe 7 is connected with the driving phase inlet 50 through a pipeline, and a peristaltic pump II 7-1 and a buffer bottle II 7-2 are sequentially arranged on the pipeline from the condenser pipe 7 to the driving phase inlet 50.
The peristaltic pump I2-3 and the buffer bottle I2-4 are arranged in the heat preservation box 1.
Interior syringe needle 4 imbeds in the outer syringe needle 3, and interior syringe needle 4 and the coaxial setting of outer syringe needle 3, the lower extreme of interior syringe needle 4 exceeds the lower extreme 0.2mm of outer syringe needle 3.
Add feed tank 2 and include outer cavity 20, interior cavity 21, temperature sensor 22, heating plate 23, two 24 of heating plate and fixed disc 25, in interior cavity 21 imbeds outer cavity 20, temperature sensor 22 and interior cavity 21 upper end center fastening connection, and insert in interior cavity 21, a 23 of heating plate and the laminating of outer cavity 20 outer wall, 20 bottoms of outer cavity are located to two 24 of heating plate, and by fixed disc 25 fastening connection, interior cavity 21 is built-in to go into gelatin solution.
The first heating sheet 23 is coiled into a cylindrical shape and covers the outer wall of the outer cavity 20.
The gelatin solution has flocculation properties, such as: PLGA, gelatin, chitosan, or polyacrylamide.
The driving liquid adopts liquid paraffin; the syringe pump 6 is provided with an oily core solution, such as: abamectin, azoxystrobin, acetochlor or glyphosate.
A method for preparing avermectin micro-droplets based on a flow focusing technology specifically comprises the following steps,
step S1: the first heating sheet 23 and the second heating sheet 24 are electrified and heated, and are kept at a constant temperature by the heat insulation box 1;
step S2: when the temperature sensor 22 reaches the calibration temperature, the injection pump 6, the peristaltic pump I2-3 and the peristaltic pump II 7-1 are started simultaneously, the injection pump 6 injects the oily core solution into the inner needle 4, and then the oily core solution flows out from the bottom; the peristaltic pump I2-3 extracts the gelatin solution from the inner chamber 21, injects the gelatin solution into the buffer bottle I2-4, enters an annular cavity formed between the outer needle head 3 and the inner needle head 4, and then flows out from the bottom; the peristaltic pump II 7-1 extracts the driving liquid condensed by the condenser pipe 7 from the condenser pipe 7, injects the driving liquid into the buffer bottle II 7-2, enters the driving phase inlet 50 and then flows to the driving phase outlet 51;
step S3: the driving liquid flowing to the driving phase outlet 51 provides a constraining force for the micro-droplet phase consisting of the oily inner core solution flowing out from the bottom of the inner needle 4 and the gelatin solution flowing out from the annular cavity formed between the outer needle 3 and the inner needle 4 to form a stable cone, the micro-droplet phase further passes through the driving phase outlet 51 to form a jet flow column, and the jet flow column is finally broken into micro-droplets due to unbalanced disturbance of surface propagation in the external environment.
The avermectin micro-droplet preparation device based on the flow focusing technology applies the flow focusing technology to the preparation of avermectin microcapsules, solves the problems of reduction of pesticide effect and stability caused by rapid passivation of avermectin in soil, and has good slow release effect and high embedding rate, thereby improving the utilization rate of the avermectin.
The avermectin micro-droplet preparation device based on the flow focusing technology has the advantages of simple structure and convenience in operation, obviously reduces the preparation cost of the microcapsule, and is suitable for industrial production.
The avermectin microcapsule prepared by the avermectin micro-droplet preparation method based on the flow focusing technology has good product dispersibility, and solves the problem of non-uniform drug action.
The prepared abamectin microcapsule has the advantages that the particle size of the product is accurate and controllable, the flow of abamectin solution, gelatin solution and driving liquid is indirectly controlled by controlling the injection pump 6, the peristaltic pump I2-3 and the peristaltic pump II 7-1, and the stability of a cone-jet flow mode is controlled, so that the particle size of micro-droplets formed by jet flow crushing caused by unstable propagation along disturbance of the jet flow surface is controlled, the microcapsule product with proper particle size is prepared, and the full play of drug effect is facilitated.
The present invention has been described in connection with the accompanying drawings, and it is to be understood that the invention is not limited to the specific embodiments described above, but is intended to cover various insubstantial modifications of the invention based on the principles and technical solutions of the invention; the present invention is not limited to the above embodiments, and can be modified in various ways.
Claims (8)
1. An avermectin micro-droplet preparation device based on flow focusing technology is characterized in that: comprises an insulation can (1), a feeding can (2), an outer needle (3), an inner needle (4), a cavity chamber (5), an injection pump (6) and a condensation pipe (7), wherein the feeding can (2) is arranged in the insulation can (1), the inner needle (4) is embedded into the outer needle (3), the outer needle (3) is fixed in the cavity chamber (5) through a rubber plug, the cavity chamber (5) is filled with a driving liquid, the side surface of the cavity chamber (5) is provided with a driving phase inlet (50), the central position of the bottom of the cavity chamber (5) is provided with a driving phase outlet (51), the feeding can (2) and the outer needle (3) are connected through a pipeline, and a peristaltic pump I (2-3) and a buffer bottle I (2-4) are sequentially arranged on the pipeline along the direction of the outer needle (3) of the feeding can (2), the liquid outlet end of the injection pump (6) is communicated with the upper end of the inner needle (4) through a pipeline, the condenser pipe (7) is arranged right below the driving phase outlet (51), the condenser pipe (7) is connected with the driving phase inlet (50) through a pipeline, and a peristaltic pump II (7-1) and a buffer bottle II (7-2) are sequentially arranged on the pipeline from the condenser pipe (7) to the driving phase inlet (50).
2. The avermectin micro-droplet preparation device based on the flow focusing technology as claimed in claim 1, wherein: the peristaltic pump I (2-3) and the buffer bottle I (2-4) are arranged in the heat preservation box (1).
3. The avermectin micro-droplet preparation device based on the flow focusing technology as claimed in claim 1, wherein: interior syringe needle (4) imbed in outer syringe needle (3), and interior syringe needle (4) and outer syringe needle (3) coaxial setting, the lower extreme of interior syringe needle (4) surpasss the lower extreme 0.2mm of outer syringe needle (3).
4. The avermectin micro-droplet preparation device based on the flow focusing technology as claimed in claim 1, wherein: add feed tank (2) and include outer chamber (20), interior chamber (21), temperature sensor (22), heating plate (23), heating plate two (24) and fixed disc (25), in outer chamber (20) of interior chamber (21) embedding, temperature sensor (22) and interior chamber (21) upper end center fastening connection, and insert in interior chamber (21), heating plate (23) and outer chamber (20) outer wall laminating, outer chamber (20) bottom is located in heating plate two (24), and by fixed disc (25) fastening connection, interior chamber (21) is built-in to glue solution.
5. The avermectin micro-droplet preparation device based on the flow focusing technology as claimed in claim 4, wherein: the first heating sheet (23) is coiled into a cylindrical shape and covers the outer wall of the outer cavity (20).
6. The avermectin micro-droplet preparation device based on the flow focusing technology as claimed in claim 4, wherein: the gelatin solution has flocculation properties, such as: PLGA, gelatin, chitosan, or polyacrylamide.
7. The avermectin micro-droplet preparation device based on the flow focusing technology as claimed in claim 1, wherein: the driving liquid adopts liquid paraffin; the syringe pump (6) is internally provided with an oily core solution, such as: abamectin, azoxystrobin, acetochlor or glyphosate.
8. A preparation method of abamectin micro-droplets based on a flow focusing technology is characterized by comprising the following steps: the method specifically comprises the following steps of,
step S1: the first heating sheet (23) and the second heating sheet (24) are electrified and heated, and are kept at a constant temperature by the heat preservation box (1);
step S2: when the temperature sensor (22) reaches a calibration temperature, the injection pump (6), the peristaltic pump I (2-3) and the peristaltic pump II (7-1) are started simultaneously, the injection pump (6) injects the oily core solution into the inner needle head (4), and then the oily core solution flows out from the bottom; the peristaltic pump I (2-3) extracts the gelatin solution from the inner chamber (21), injects the gelatin solution into the buffer bottle I (2-4), enters an annular cavity formed between the outer needle head (3) and the inner needle head (4), and then flows out from the bottom; the peristaltic pump II (7-1) pumps the driving liquid condensed by the condensing tube (7) out of the condensing tube (7), and the driving liquid is injected into the buffer bottle II (7-2), enters the driving phase inlet (50) and then flows to the driving phase outlet (51);
step S3: the driving liquid flowing to the driving phase outlet (51) provides constraint force for a micro-droplet phase consisting of an oily inner core solution flowing out from the bottom of the inner needle (4) and a gelatin solution flowing out from an annular cavity formed between the outer needle (3) and the inner needle (4) to form a stable cone, the micro-droplet phase further passes through the driving phase outlet (51) to form a jet flow column, and the jet flow column is finally broken into micro-droplets due to unbalanced disturbance of surface propagation in an external environment.
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