CN110524769A - Gel tube preparation facilities and its micron order gel tube obtained for Glaucoma Drainage - Google Patents
Gel tube preparation facilities and its micron order gel tube obtained for Glaucoma Drainage Download PDFInfo
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- CN110524769A CN110524769A CN201910951966.6A CN201910951966A CN110524769A CN 110524769 A CN110524769 A CN 110524769A CN 201910951966 A CN201910951966 A CN 201910951966A CN 110524769 A CN110524769 A CN 110524769A
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- wire
- gel
- gel tube
- cavity
- tube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/24—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of indefinite length
- B29C41/30—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of indefinite length incorporating preformed parts or layers, e.g. moulding around inserts or for coating articles
Abstract
The present invention provides a kind of gel tube preparation facilities and its micron order gel tubes obtained for Glaucoma Drainage, are related to medicine new material technology field, which includes gel cavity, wire and wire-drawing frame；The gel inner cavity and heat preservation exocoel that the gel cavity is mainly arranged by interior outer cladding form；Simultaneously, gel cavity is provided with wire import and wire outlet, the wire enters gel cavity by wire import by wire-drawing frame, and it is pierced by after adhesive gel from the center that wire exports in gel inner cavity, obtain the wire that external sheath has gel, wire is extracted out after cured molding, and gel tube is prepared；In addition, the internal diameter of the wire outlet and the ratio of wire diameter are 4~2:1.There is for the micron order gel tube of Glaucoma Drainage relative to the hose that existing solution absorption freezing method is prepared the advantage of surfacing, even thickness as made from above-mentioned preparation facilities.
Description
Technical field
The present invention relates to medical new material technology fields, more particularly, to a kind of gel tube preparation facilities and its use obtained
In the micron order gel tube of Glaucoma Drainage.
Background technique
Glaucoma is one of three big diseases causing blindnesses of the mankind, and total crowd's disease incidence is 1%, and 45 years old is 2% later.Green light
Eye can cause the unusual high pressure in eyes, so as to cause optic nerve injury.With the growth of patient age, intraocular pressure will be increased persistently
Lasting damage is caused to optic nerve.Current primary treatments concentrate on reducing intraocular pressure, keep intraocular pressure in normal range
Within, guarantee that patient is able to maintain certain eyesight.
Traditional treatment method includes being led to using drug to reduce intraocular pressure.However, drug therapy can cause much not
Good reaction can not accurately control intraocular pressure.Moreover, patient is often listless in drug treatment, patient is influenced
Normal life.In addition to drug therapy, Glaucoma Drainage valve gear is implanted by surgical operation, the drainage valve gear is by by anterior chamber
In aqueous humor discharge, thus reach reduce intraocular pressure curative effect.However present Glaucoma Drainage valve gear volume is larger, wound compared with
Weight, it is postoperative to be easy to cause infection, leave cicatricial tissue, it is serious or even need second operation.In addition to draining valve gear, metal draws
Stream nail is also method more commonly used recently, however metal drainage nail quality is harder, and foreign body sensation is strong, and patient's use feeling is poor.
In recent years, also occur some exporting to aqueous humor in trabecular network using micron order hose as Glaucoma Drainage pipe
To reduce the therapeutic scheme of intraocular pressure, however existing micron order hose is prepared using the method for solution absorption solidification,
Such as disclose one in CN107811752A and tubular form is added in chitosan solution, it is adsorbed followed by chitosan solidifying
Solid method prepare the scheme of micron order hose, but hose made from this kind of scheme there is a problem of one it is obvious be exactly soft
Pipe surface out-of-flatness, thickness are also uneven, while this kind of scheme preparation process is complicated, time and effort consuming, and economy is also poor.
Therefore, it researchs and develops that a kind of preparation process is simple, process is easily-controllable, while there is surfacing, even thickness is excellent
The micron order gel tube and its preparation facilities for Glaucoma Drainage of point, are prepared hose to alleviate existing cladding freezing method
Preparation process is complicated, surface irregularity, and thickness also non-uniform problem becomes very necessary and urgent.
In view of this, the present invention is specifically proposed.
Summary of the invention
The first object of the present invention is to provide a kind of gel tube preparation facilities, gel made from the gel tube preparation facilities
Pipe has the advantage of surfacing, even thickness relative to the hose that existing solution absorption freezing method is prepared.
The second object of the present invention is to provide a kind of gel tube, and the gel tube is mainly by above-mentioned gel tube preparation facilities
It is made.
The third object of the present invention is to provide a kind of preparation method of gel tube, and the preparation method is relative to existing molten
Liquid, which adsorbs freezing method, has preparation process simple, the easily-controllable advantage of process.
The fourth object of the present invention is to provide a kind of micron order gel tube for Glaucoma Drainage, this is used for glaucoma
The micron order gel tube of drainage has the advantage of surfacing, internal-and external diameter even thickness, while also having more is suitable for glaucoma
Aqueous humor drainage internal-and external diameter.
The fifth object of the present invention is to provide a kind of preparation method of micron order gel tube for Glaucoma Drainage.
A kind of gel tube preparation facilities provided by the invention, the preparation facilities include gel cavity, wire and wire drawing
Device；
The gel inner cavity and heat preservation exocoel that the gel cavity is mainly arranged by interior outer cladding form；
The gel cavity is provided with wire import and wire outlet, and the wire is by wire-drawing frame by metal
Silk import enters gel cavity, and is pierced by after adhesive gel from the center that wire exports in gel inner cavity, obtains outer layer packet
It is covered with the wire of gel, wire is extracted out after cured molding, gel tube is prepared；
The internal diameter of the wire outlet and the ratio of wire diameter are 4~2:1.
Further, gel solution is injected in the gel inner cavity；Heat preservation liquid is injected in the heat preservation exocoel.
Further, the heat preservation exocoel is provided with heat preservation liquid entrance and the outlet of heat preservation liquid, for keeping the temperature the flowing of liquid.
Further, the wire outlet is provided with cooler, and the external sheath being pierced by from wire outlet has
The wire of gel protrudes into cooler, and the gel adhered to wire outer layer cools and solidifies.
Further, the wire-drawing frame includes into idler wheel and guide roller；
Wherein, it is described enter an idler wheel for controlling the direction that wire enters gel cavity；The guide roller is for controlling
The direction that wire processed is pierced by from cooler；
Preferably, the wire-drawing frame further includes wind-up roll shaft, for pulling wire and pulling out to guide roller outer
The wire that layer is coated with curing gel is wound.
A kind of gel tube provided by the invention, the gel tube are mainly made by above-mentioned gel tube preparation facilities.
Further, the gel tube is mainly made by macromolecule hydrogel material；
Preferably, the gel tube is mainly made by biocompatible hydrogel material；
It is highly preferred that the gel tube is mainly made by gelatin.
A kind of preparation method of above-mentioned gel tube provided by the invention, the described method comprises the following steps:
Wire is entered into gel cavity by wire import by wire-drawing frame, and adheres to macromolecule in gel inner cavity
The gel solution of hydrogel material is then pierced by from the center that wire exports, so that wire surface is stained with gel solution, so
There is the wire of gel solution to solidify surface adhesion afterwards, finally extract wire out, obtains gel tube.
A kind of micron order gel tube for Glaucoma Drainage provided by the invention, the gel tube is mainly by above-mentioned gel
Pipe preparation facilities is made；
Wherein, the internal diameter that wire exports in the preparation facilities is 300~1000 μm, the diameter of wire is 100~
500μm；
The micron order gel tube for Glaucoma Drainage is mainly made by gelatin；
Preferably, the internal diameter that wire exports in the preparation facilities is 400 μm, and the diameter of wire is 100 μm.
The preparation method of the above-mentioned micron order gel tube for Glaucoma Drainage of one kind provided by the invention, the method packet
Include following steps:
Wire is entered into gel cavity by wire import by wire-drawing frame, and adherency gelatin is molten in gel inner cavity
Liquid is then pierced by from the center that wire exports, so that wire surface is stained with gelatin solution, surface adhesion is then had gelatin
The wire of solution is successively solidified, is crosslinked, is dried；It finally extracts wire out, obtains the micron order for Glaucoma Drainage
Gel tube；
Preferably, the method specifically includes the following steps:
(a), gelatin solution is added in gel inner cavity, and the injection heat preservation liquid in heat preservation exocoel；
(b), wire is entered into gel cavity by wire import by wire-drawing frame, and adhered in gel inner cavity bright
Sol solution is then pierced by from the center that wire exports, obtains the wire that surface adhesion has gelatin solution；
(c), there is the wire of gelatin solution successively to be solidified step (b) surface adhesion, be crosslinked, dry；Finally take out
Wire out obtains the micron order gel tube for Glaucoma Drainage；
Preferably, the concentration of the gelatin is 0.25~0.70g/ml；
Preferably, the water that the heat preservation liquid is 45~70 DEG C；
Preferably, the crosslinking agent of the crosslinking is polynary aldehydes solution；
It is highly preferred that the crosslinking agent of the crosslinking is the glutaraldehyde solution of volume mass score 0.5~1%；
Preferably, the time of the crosslinking be 2~for 24 hours；
It is highly preferred that the time of the crosslinking is for 24 hours；
Preferably, the time of the drying is 12~48h；
It is highly preferred that the time of the drying is for 24 hours.
Compared with prior art, the invention has the benefit that
Gel tube preparation facilities provided by the invention, the preparation facilities include gel cavity, wire and wire-drawing frame；Institute
It states the gel inner cavity that gel cavity is mainly arranged by interior outer cladding to form with heat preservation exocoel, wherein gel inner cavity is solidifying for storing
Glue, heat preservation exocoel for keeping the temperature, to avoid during preparing gel tube gel be cured；Meanwhile gel cavity is arranged
There are wire import and wire outlet, the wire enters gel cavity by wire import by wire-drawing frame, and
It is pierced by after adhesive gel from the center that wire exports in gel inner cavity, obtains the wire that external sheath has gel, it is cured
It extracts wire after molding out, gel tube is prepared；In addition, the internal diameter of the wire outlet and the ratio of wire diameter are
4~2:1.The special ratios of the internal diameter and wire diameter that are exported by above-mentioned wire are arranged, and can to go out from wire
The periphery gel that wire is pierced by mouthful is scraped attached visibly homogeneous, while the periphery of gel is also more smooth.Therefore, by above-mentioned system
Gel tube made from standby device has surfacing, thickness equal relative to the hose that existing solution absorption freezing method is prepared
Even advantage.
Gel tube provided by the invention, the gel tube are mainly made by above-mentioned gel tube preparation facilities.The gel tube is opposite
Have the advantages that surfacing, internal-and external diameter even thickness in the hose that existing solution absorption freezing method is prepared.
The preparation method of gel tube provided by the invention, this method by wire by wire-drawing frame by wire import into
Enter gel cavity, and adhere to the gel solution of macromolecule hydrogel material in gel inner cavity, then from wire outlet
The heart is pierced by, and wire surface is made to be stained with gel solution, then has the wire of gel solution to solidify surface adhesion, most
After extract wire out, obtain gel tube.The preparation method of above-mentioned gel tube has system relative to existing solution absorption freezing method
Standby simple process, the easily-controllable advantage of process are fully compatible for heavy industrialization and quickly produce.
Provided by the present invention for the micron order gel tube of Glaucoma Drainage, which is mainly prepared by above-mentioned gel tube
Device is made；Wherein, the internal diameter that wire exports in above-mentioned preparation facilities is 300~1000 μm, and the diameter of wire is 100
~500 μm；The micron order gel tube for Glaucoma Drainage is mainly made by gelatin.This is used for the micron of Glaucoma Drainage
Grade gel tube is prepared by above-mentioned apparatus and material, the advantage with surfacing, internal-and external diameter even thickness, while also being had
There is the internal-and external diameter of the aqueous humor drainage of more suitable glaucoma.
Provided by the present invention for the preparation method of the micron order gel tube of Glaucoma Drainage, this method passes through wire
Wire-drawing frame enters gel cavity by wire import, and gelatin solution is adhered in gel inner cavity, then exports from wire
Center be pierced by, so that wire surface is stained with gelatin solution, then by surface adhesion have the wire of gel solution successively into
Row solidification, crosslinking, drying；It finally extracts wire out, obtains the micron order gel tube for Glaucoma Drainage；Above-mentioned preparation method
Relative to the existing method for preparing Glaucoma Drainage using solution absorption freezing method, have preparation process simple, process is easily-controllable
Advantage.
Detailed description of the invention
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art
Embodiment or attached drawing needed to be used in the description of the prior art be briefly described, it should be apparent that, it is described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, is also possible to obtain other drawings based on these drawings.
Fig. 1 is the gel tube preparation facilities structural schematic diagram that the embodiment of the present invention 1 provides.
Icon: 1- gel cavity；2- wire；11- wire import；The outlet of 12- wire；13- gel inner cavity；14-
Keep the temperature exocoel；141- keeps the temperature liquid entrance；142- keeps the temperature liquid outlet；4- cooler；3- wire-drawing frame；31- enters an idler wheel；32- draws
Guide roll wheel；33- wind-up roll shaft.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation
Example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill
Personnel's every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
According to an aspect of the present invention, a kind of gel tube preparation facilities, the preparation facilities include gel cavity 1, gold
Belong to silk 2 and wire-drawing frame 3；
The gel inner cavity 13 and heat preservation exocoel 14 that the gel cavity 1 is mainly arranged by interior outer cladding form；
The gel cavity 1 is provided with wire import 11 and wire outlet 12, and the wire 2 is filled by wire drawing
Set 3 by wire import 11 enter gel cavity 1, and in gel inner cavity 13 after adhesive gel from wire outlet 12 center
It is pierced by, obtains the wire 2 that external sheath has gel, extract wire 2 after cured molding out, gel tube is prepared；
The ratio of 2 diameter of internal diameter and wire of the wire outlet 12 is 4~2:1.
Gel tube preparation facilities provided by the invention, the preparation facilities include gel cavity 1, wire 2 and wire-drawing frame
3；The gel inner cavity 13 and heat preservation exocoel 14 that the gel cavity 1 is mainly arranged by interior outer cladding form, wherein gel inner cavity 13
For storing gel, heat preservation exocoel 14 for keeping the temperature, to avoid during preparing gel tube gel be cured；Meanwhile
Gel cavity 1 be provided with wire import 11 and wire outlet 12, the wire 2 by wire-drawing frame 3 by wire into
Mouth 11 enters gel cavity 1, and is pierced by after adhesive gel from the center of wire outlet 12 in gel inner cavity 13, obtains outer
Layer is coated with the wire 2 of gel, extracts wire 2 after cured molding out, gel tube is prepared；In addition, the wire
The ratio of 2 diameter of internal diameter and wire of outlet 12 is 4~2:1.Pass through the internal diameter and wire 2 of above-mentioned wire outlet 12
The special ratios of diameter are arranged, and the periphery gel for being pierced by wire 2 from wire outlet 12 can be made to scrape very attached
It is even, while the periphery of gel is also more smooth.Therefore, the gel tube as made from above-mentioned preparation facilities is inhaled relative to existing solution
The hose that attached freezing method is prepared has the advantage of surfacing, even thickness.
In the preferred embodiment of the present invention, macromolecule hydrogel material is injected in the gel inner cavity 13
Gel solution；Heat preservation liquid is injected in the heat preservation exocoel 14.
As a preferred embodiment, the gel for being injected with macromolecule hydrogel material in above-mentioned gel inner cavity 13 is molten
Liquid, the gel solution is further to prepare gel tube；It is injected with heat preservation liquid in above-mentioned heat preservation exocoel 14, the guarantor for gel
Temperature, to avoid during preparing gel tube gel be cured.
In the preferred embodiment of the present invention, the heat preservation exocoel 14 is provided with heat preservation liquid entrance 141 and heat preservation
Liquid outlet 142, for keeping the temperature the flowing of liquid.
As a preferred embodiment, above-mentioned heat preservation exocoel 14 is provided with heat preservation liquid entrance 141 and the outlet of heat preservation liquid
142, for keeping the temperature the flowing of liquid, the temperature to realize heat preservation liquid is constant, and gel during preparing gel tube is avoided to cool down
Solidification.
In the preferred embodiment of the present invention, the wire outlet 12 is provided with and communicated with cooler 4, from metal
The external sheath that silk outlet 12 is pierced by has the wire 2 of gel to protrude into cooler 4, the gel adhered to 2 outer layer of wire
It is cooled and solidified.
As a preferred embodiment, the cooler 4 can be cooling pipe.
In the preferred embodiment of the present invention, the wire-drawing frame 3 includes into idler wheel 31 and guide roller 32；
Wherein, it is described enter an idler wheel 31 be used for control wire 2 enter gel cavity 1 direction；The guide roller 32
The direction being pierced by from cooler 4 for controlling wire 2；
Preferably, it is described enter an idler wheel 31 and guide roller 32 be in same horizontal line so that wire 2 is in gel chamber
Horizontality is in body 1.
In the preferred embodiment of the present invention, the wire-drawing frame 3 further includes wind-up roll shaft 33, for pulling gold
Belong to silk 2 and the external sheath pulled out to guide roller 32 has the wire 2 of curing gel to wind.
According to an aspect of the present invention, a kind of gel tube, the gel tube is mainly by above-mentioned gel tube preparation facilities system
.
Gel tube provided by the invention, the gel tube are mainly made by above-mentioned gel tube preparation facilities.The gel tube is opposite
Have the advantages that surfacing, internal-and external diameter even thickness in the hose that existing solution absorption freezing method is prepared.
In the preferred embodiment of the present invention, the gel tube is mainly made by macromolecule hydrogel material；
As a preferred embodiment, the gel tube is mainly made by gelatin, pigskin source gelatin, gelatin are selected
Glue intensity be 170-195g Bloom.It is dissolved in the hot water that the optimal solution temperature of gelatin is 45 DEG C~60 DEG C in this method.
After being dissolved in hot water, gelled after cooling.Dry state gel tube is obtained after drying, in water can water absorption and swelling, volume increase, can rise
To the effect of self-retaining, gelatin hydrogel has preferable flexibility.
According to an aspect of the present invention, a kind of preparation method of above-mentioned gel tube, the described method comprises the following steps:
Wire 2 is entered into gel cavity 1 by wire import 11 by wire-drawing frame 3, and is glued in gel inner cavity 13
Attached gel solution is then pierced by from the center of wire outlet 12, so that 2 surface adhesion of wire is had gel solution, then by table
The wire 2 that face is stained with gel solution is solidified, and is finally extracted wire 2 out, is obtained gel tube.
The preparation method of gel tube provided by the invention, this method by wire 2 by wire-drawing frame 3 by wire into
Mouth 11 enters gel cavity 1, and the gel solution of macromolecule hydrogel material is adhered in gel inner cavity 13, then from wire
The center of outlet 12 is pierced by, and so that 2 surface adhesion of wire is had gel solution, then surface adhesion is had to the wire of gel solution
2 are solidified, and are finally extracted wire 2 out, are obtained gel tube.The preparation method of above-mentioned gel tube is adsorbed relative to existing solution
Freezing method has preparation process simple, and the easily-controllable advantage of process is fully compatible for heavy industrialization and quickly produces.
According to an aspect of the present invention, a kind of micron order gel tube for Glaucoma Drainage, the gel tube are main
It is made by above-mentioned gel tube preparation facilities；
Wherein, the internal diameter of wire outlet 12 is 300~1000 μm in the preparation facilities, and the diameter of wire 2 is
100~500 μm；
The micron order gel tube for Glaucoma Drainage is mainly made by gelatin；
Provided by the present invention for the micron order gel tube of Glaucoma Drainage, which is mainly prepared by above-mentioned gel tube
Device is made；Wherein, the internal diameter of wire outlet 12 is 300~1000 μm in above-mentioned preparation facilities, and the diameter of wire 2 is
100~500 μm；The micron order gel tube for Glaucoma Drainage is mainly made by gelatin.This is for Glaucoma Drainage
Micron order gel tube is prepared by above-mentioned apparatus and material, the advantage with surfacing, internal-and external diameter even thickness, simultaneously
Also there is the internal-and external diameter of the aqueous humor drainage of more suitable glaucoma.
In the preferred embodiment of the present invention, the internal diameter of wire outlet 12 is 400 μm in the preparation facilities,
When the diameter of wire 2 is 100 μm, the micron order gel tube drainage effect obtained for Glaucoma Drainage is optimal.
According to an aspect of the present invention, a kind of preparation method of the above-mentioned micron order gel tube for Glaucoma Drainage,
It the described method comprises the following steps:
Wire 2 is entered into gel cavity 1 by wire import 11 by wire-drawing frame 3, and is glued in gel inner cavity 13
Attached gelatin solution is then pierced by from the center of wire outlet 12, so that 2 surface adhesion of wire is had gelatin solution, then by table
The wire 2 that face is stained with gel solution is successively solidified, is crosslinked, is dried；It finally extracts wire 2 out, obtains for green light
The micron order gel tube of eye drainage；
Provided by the present invention for the preparation method of the micron order gel tube of Glaucoma Drainage, this method leads to wire 2
It crosses wire-drawing frame 3 and gel cavity 1 is entered by wire import 11, and adhere to gelatin solution in gel inner cavity 13, then from gold
The center for belonging to silk outlet 12 is pierced by, and so that 2 surface adhesion of wire is had gelatin solution, then surface adhesion is had to the gold of gel solution
Belong to silk 2 successively to be solidified, be crosslinked, dried；It finally extracts wire 2 out, obtains the micron order gel tube for Glaucoma Drainage；
Above-mentioned preparation method has preparation process letter relative to the existing method for preparing Glaucoma Drainage using solution absorption freezing method
It is single, the easily-controllable advantage of process.
In the preferred embodiment of the present invention, the method specifically includes the following steps:
(a), gelatin solution is added in gel inner cavity 13, and the injection heat preservation liquid in heat preservation exocoel 14；
(b), wire 2 is entered into gel cavity 1 by wire import 11 by wire-drawing frame 3, and in gel inner cavity 13
Middle adherency gelatin solution is then pierced by from the center of wire outlet 12, obtains the wire 2 that surface adhesion has gelatin solution；
(c), there is the wire 2 of gelatin solution successively to be solidified step (b) surface adhesion, be crosslinked, dry；Finally take out
Wire 2 out obtain the micron order gel tube for Glaucoma Drainage；
In above-mentioned preferred embodiment, the concentration that the gelatin is is 0.25~0.70g/ml；
In above-mentioned preferred embodiment, the water for keeping the temperature liquid and being 45~70 DEG C；
In above-mentioned preferred embodiment, the crosslinking agent of the crosslinking is the glutaraldehyde of volume mass score 0.5~1%
Solution；
In above-mentioned preferred embodiment, time of the crosslinking is 2~for 24 hours；
Preferably, the time of the crosslinking is for 24 hours.
In above-mentioned preferred embodiment, the time of the drying is 12~48h.
Preferably, the time of the drying is for 24 hours.
Technical solution of the present invention is described further below in conjunction with embodiment and attached drawing.
Embodiment 1
As shown in Figure 1, a kind of gel tube preparation facilities, the preparation facilities includes gel cavity 1, wire 2 and wire drawing
Device 3；
The gel inner cavity 13 and heat preservation exocoel 14 that the gel cavity 1 is mainly arranged by interior outer cladding form；
The gel cavity 1 is provided with wire import 11 and wire outlet 12, and the wire 2 is filled by wire drawing
Set 3 by wire import 11 enter gel cavity 1, and in gel inner cavity 13 after adhesive gel from wire outlet 12 center
It is pierced by, obtains the wire 2 that external sheath has gel, extract wire 2 after cured molding out, gel tube is prepared；
The ratio of 2 diameter of internal diameter and wire of the wire outlet 12 is 4~2:1.
Gel tube preparation facilities provided in this embodiment, the preparation facilities include gel cavity 1, wire 2 and wire drawing dress
Set 3；The gel inner cavity 13 and heat preservation exocoel 14 that the gel cavity 1 is mainly arranged by interior outer cladding form, wherein gel inner cavity
13 for storing gel, heat preservation exocoel 14 for keeping the temperature, to avoid during preparing gel tube gel be cured；Together
When, gel cavity 1 is provided with wire import 11 and wire outlet 12, and the wire 2 is by wire-drawing frame 3 by wire
Import 11 enters gel cavity 1, and is pierced by after adhesive gel from the center of wire outlet 12 in gel inner cavity 13, obtains
External sheath has the wire 2 of gel, extracts wire 2 after cured molding out, gel tube is prepared；In addition, the metal
The ratio of 2 diameter of internal diameter and wire of silk outlet 12 is 4~2:1.Pass through the internal diameter and wire of above-mentioned wire outlet 12
The special ratios of 2 diameters are arranged, and the periphery gel for being pierced by wire 2 from wire outlet 12 can be made to scrape very attached
It is even, while the periphery of gel is also more smooth.Therefore, the gel tube as made from above-mentioned preparation facilities is inhaled relative to existing solution
The hose that attached freezing method is prepared has the advantage of surfacing, even thickness.
In the preferred embodiment of the present invention, macromolecule hydrogel material is injected in above-mentioned gel inner cavity 13
Gel solution, the gel solution is further to prepare gel tube；It is injected with heat preservation liquid in above-mentioned heat preservation exocoel 14, for coagulating
The heat preservation of glue, to avoid during preparing gel tube gel be cured.
Referring to Fig. 1, in the preferred embodiment of the present invention, the heat preservation exocoel 14 is provided with heat preservation liquid entrance
141, to realize that the temperature for keeping the temperature liquid is constant, avoid preparing gel tube with heat preservation liquid outlet 142 for keeping the temperature the flowing of liquid
Gel cooling solidification in the process.
Referring to Fig. 1, in the preferred embodiment of the present invention, the wire outlet 12 is provided with and communicated with cooler
4, the external sheath being pierced by from wire outlet 12 has the wire 2 of gel to protrude into cooler 4, glues to 2 outer layer of wire
Attached gel is cooled and solidified.
Preferably, the cooler 4 can be cooling pipe.
With continued reference to Fig. 1, in the preferred embodiment of the present invention, the wire-drawing frame 3 includes into idler wheel 31
With guide roller 32；Wherein, it is described enter an idler wheel 31 be used for control wire 2 enter gel cavity 1 direction；The guidance rolling
Wheel 32 is for controlling the direction that wire 2 is pierced by from cooler 4；
It is described enter an idler wheel 31 and guide roller 32 be in same horizontal line so that wire 2 is in gel cavity 1
In horizontality.
With continued reference to Fig. 1, in the preferred embodiment of the present invention, the wire-drawing frame 3 further includes wind-up roll shaft
33, for pulling wire 2 and thering is the wire 2 of curing gel to wind the external sheath of the pull-out of guide roller 32.
The specific work process of the present embodiment gel tube preparation facilities are as follows: gel inner cavity 13 is added in gelatin solution first
In, and the injection heat preservation liquid in heat preservation exocoel 14；Then wire 2 is entered by wire-drawing frame 3 by wire import 11 solidifying
Glue chamer body 1, and in gel inner cavity 13 adhere to macromolecule hydrogel material gel solution, then from wire outlet 12 in
The heart is pierced by, and 2 surface adhesion of wire is made to have gel solution, then has the wire 2 of gel solution to solidify surface adhesion,
It finally extracts wire 2 out, obtains gel tube.
Embodiment 2
A kind of micron order gel tube for Glaucoma Drainage, the gel tube are prepared by the gel tube of above-described embodiment 1
Device is made；
Wherein, the internal diameter of wire outlet 12 is 400 μm in the preparation facilities, and the diameter of wire 2 is 100 μm.
Specific preparation process is as follows for the above-mentioned micron order gel tube for Glaucoma Drainage:
(1), 20g gelatin solution is dissolved in 40ml water, is heated to 50 DEG C of dissolutions overnight.The gelatin solution dissolved is surpassed
It is added in gel cavity 1 after sound deaeration；
(2), before preparation starts, hot water enters from heat preservation liquid entrance 141, guarantees the temperature of gelatin solution by heat preservation exocoel 14
Degree is maintained at 50 DEG C or so, is unlikely to solidify during preparing gel tube, while hot water has been flowed out from heat preservation liquid outlet 142
At entire hot water circuit；
(3), wire 2 is passed through and passes through gel cavity 1, guided idler wheel into idler wheel 31 by the formative stage of gel tube
32, finally wound by wind-up roll shaft 33；
Wire 2 will stick gelatin solution by 13 surface of gel inner cavity, can by the openings of sizes of wire outlet 12
To control the outer diameter of gelatin tube, the internal diameter of wire outlet 12 is 400 μm in the present embodiment, adsorbs the wire 2 of gelatin solution
Diameter determine final gelatin tube internal diameter after molding, in the present embodiment the diameter of wire 2 be 100 μm, adsorbed gelatin
The wire 2 of solution winds collection by wind-up roll shaft 33 after guide roller 32 after passing through 4 gel solidification of cooler；
(4), the length for 6mm is truncated in the wire 2 that the outer layer gathered is wrapped with gelatin gel, is then added 0.5%
After being crosslinked for 24 hours in the glutaraldehyde of volume mass score, completion to be dried for 24 hours is dried, the wire 2 of core is extracted out, has been prepared
At obtaining 400 μm of outer diameter, 100 μm of internal diameter of the micron order gel tube for Glaucoma Drainage.
Embodiment 3
A kind of micron order gel tube for Glaucoma Drainage, the present embodiment are 300 μm except the internal diameter of wire outlet 12,
The diameter of wire 2 is 100 μm outer, remaining is the same as embodiment 2.
Embodiment 4
A kind of micron order gel tube for Glaucoma Drainage, the present embodiment are 500 μm except the internal diameter of wire outlet 12,
The diameter of wire 2 is 100 μm outer, remaining is the same as embodiment 2.
Embodiment 5
A kind of micron order gel tube for Glaucoma Drainage, the gel tube are prepared by the gel tube of above-described embodiment 1
Device is made；
Wherein, the internal diameter of wire outlet 12 is 400 μm in the preparation facilities, and the diameter of wire 2 is 100 μm.
Specific preparation process is as follows for the above-mentioned micron order gel tube for Glaucoma Drainage:
1,10gGelMA solution is dissolved in 50ml PBS solution, for 24 hours, the GelMA solution ultrasound dissolved is taken off for dissolution
It is added in gel inner cavity 13 after bubble.
2, the formative stage of gel tube, by wire 2 pass through into idler wheel 31 pass through gel cavity 1, guided idler wheel 32,
Finally wound by wind-up roll shaft 33.Wire 2 passes through gel inner cavity 13, and surface will stick GelMA solution, and be exported by wire
12 openings of sizes can control the outer diameter of gel tube, and it is 400 μm that wire, which exports the internal diameter at 12 most narrow places, in the present embodiment, inhale
The wire 2 of attached gelatin solution determines final gel tube internal diameter after molding, we select wire 2 in the present embodiment
Diameter is 100 μm.Adsorbed the wire 2 of GelMA solution by after gel cavity 1 by after guide roller 32 by wind-up roll shaft
33 windings are collected.
3, the length for 6mm is truncated in the wire 2 that the outer layer gathered is wrapped with gelatin gel, with wavelength 365nm, light intensity
10mW/cm2Ultraviolet source solidification 12h after, preparation complete obtain 400 μm of outer diameter, 100 μm of internal diameter of GelMA gel tube.
Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Pipe present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: its according to
So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into
Row equivalent replacement；And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (10)
1. a kind of gel tube preparation facilities, which is characterized in that the preparation facilities includes gel cavity, wire and wire drawing dress
It sets；
The gel inner cavity and heat preservation exocoel that the gel cavity is mainly arranged by interior outer cladding form；
The gel cavity be provided with wire import and wire outlet, the wire by wire-drawing frame by wire into
Mouth enters gel cavity, and is pierced by after adhesive gel from the center that wire exports in gel inner cavity, and obtaining external sheath has
The wire of gel extracts wire out after cured molding, gel tube is prepared；
The internal diameter of the wire outlet and the ratio of wire diameter are 4~2:1.
2. gel tube preparation facilities according to claim 1, which is characterized in that be injected with macromolecule in the gel inner cavity
The gel solution of hydrogel material；Heat preservation liquid is injected in the heat preservation exocoel.
3. gel tube preparation facilities according to claim 1 or 2, which is characterized in that the heat preservation exocoel is provided with heat preservation
Liquid entrance and the outlet of heat preservation liquid, for keeping the temperature the flowing of liquid.
4. gel tube preparation facilities according to claim 1, which is characterized in that the wire outlet is provided with cold
But device, the external sheath being pierced by from wire outlet have the wire of gel to protrude into cooler, are adhered to wire outer layer
Gel cooled and solidified.
5. gel tube preparation facilities according to claim 4, which is characterized in that the wire-drawing frame include into idler wheel and
Guide roller；
Wherein, it is described enter an idler wheel for controlling the direction that wire enters gel cavity；The guide roller is for controlling gold
Belong to the direction that silk is pierced by from cooler；
Preferably, the wire-drawing frame further includes wind-up roll shaft, the outer layer packet for pulling wire and pulling out to guide roller
The wire for being covered with curing gel is wound.
6. a kind of gel tube, which is characterized in that the gel tube is mainly by the described in any item gel control of Claims 1 to 5
Standby device is made.
7. gel tube according to claim 6, which is characterized in that the gel tube is mainly by macromolecule hydrogel material system
；
Preferably, the gel tube is mainly made by biocompatible hydrogel material；
It is highly preferred that the gel tube is mainly made by gelatin.
8. a kind of preparation method of gel tube according to claim 6 or 7, which is characterized in that the method includes following
Step:
Wire is entered into gel cavity by wire import by wire-drawing frame, and adheres to macromolecule water-setting in gel inner cavity
The gel solution of glue material is then pierced by from the center that wire exports, wire surface is made to be stained with gel solution, then will
Surface adhesion has the wire of gel solution to be solidified, and finally extracts wire out, obtains gel tube.
9. a kind of micron order gel tube for Glaucoma Drainage, which is characterized in that the gel tube mainly by claim 1~
5 described in any item gel tube preparation facilities are made；
The micron order gel tube for Glaucoma Drainage is mainly made by gelatin；
Preferably, the internal diameter that wire exports in the preparation facilities is 400 μm, and the diameter of wire is 100 μm.
10. a kind of preparation method of the micron order gel tube according to claim 9 for Glaucoma Drainage, feature exist
In the described method comprises the following steps:
Wire is entered into gel cavity by wire import by wire-drawing frame, and adheres to gelatin solution in gel inner cavity,
It is then pierced by from the center that wire exports, so that wire surface is stained with gelatin solution, then have gelatin molten surface adhesion
The wire of liquid is successively solidified, is crosslinked, is dried；It finally extracts wire out, obtains solidifying for the micron order of Glaucoma Drainage
Sebific duct；
Preferably, the method specifically includes the following steps:
(a), gelatin solution is added in gel inner cavity, and the injection heat preservation liquid in heat preservation exocoel；
(c), there is the wire of gelatin solution successively to be solidified step (b) surface adhesion, be crosslinked, dry；Finally extraction gold
Belong to silk, obtains the micron order gel tube for Glaucoma Drainage；
Preferably, the concentration of the gelatin is 0.25~0.70g/ml；
Preferably, the water that the heat preservation liquid is 45~70 DEG C；
Preferably, the crosslinking agent of the crosslinking is polyalcohols solution；
It is highly preferred that the crosslinking agent of the crosslinking is the glutaraldehyde solution of volume mass score 0.5~1%；
Preferably, the time of the crosslinking be 2~for 24 hours；
It is highly preferred that the time of the crosslinking is for 24 hours；
Preferably, the time of the drying is 12~48h；
It is highly preferred that the time of the drying is for 24 hours.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113070006A (en) * | 2021-04-12 | 2021-07-06 | 安徽农业大学 | Avermectin micro-droplet preparation device and method based on flow focusing technology |
| CN113769176A (en) * | 2021-08-26 | 2021-12-10 | 海思盖德(苏州)生物医学科技有限公司 | Heparin coating drainage tube for reducing intraocular pressure and preparation method thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7181287B2 (en) * | 2001-02-13 | 2007-02-20 | Second Sight Medical Products, Inc. | Implantable drug delivery device |
| CN101139689A (en) * | 2007-08-16 | 2008-03-12 | 北京科技大学 | Continuous preparation equipment and process for metal glass clad metal wire composite material |
| US20120073859A1 (en) * | 2010-09-24 | 2012-03-29 | Freescale Semiconductor, Inc | Polymer core wire |
| CN103168099A (en) * | 2010-08-25 | 2013-06-19 | 独立行政法人农业生物资源研究所 | Dried hydrogel, dried vitrigel film, and processes for producing these |
| CN104610494A (en) * | 2015-02-05 | 2015-05-13 | 中国科学院兰州化学物理研究所 | Preparation method of artificial tube |
| US20150148729A1 (en) * | 2013-11-25 | 2015-05-28 | Innfocus, Inc. | Methods, Systems and Devices for Treating Glaucoma |
| CN109071942A (en) * | 2016-03-03 | 2018-12-21 | 新加坡国立大学 | Multi-functional, flexible and biocompatible elastomer micro-pipe |
| CN109922760A (en) * | 2016-11-10 | 2019-06-21 | 美敦力瓦斯科尔勒公司 | Drug filling bracket and its manufacturing method for anti-hemostatic tube micro-damage |
| CN111361072A (en) * | 2020-03-04 | 2020-07-03 | 上海交通大学 | Non-contact heating type device and method for preparing micron-sized inner-diameter flexible polymer pipe |
-
2019
- 2019-10-08 CN CN201910951966.6A patent/CN110524769B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7181287B2 (en) * | 2001-02-13 | 2007-02-20 | Second Sight Medical Products, Inc. | Implantable drug delivery device |
| CN101139689A (en) * | 2007-08-16 | 2008-03-12 | 北京科技大学 | Continuous preparation equipment and process for metal glass clad metal wire composite material |
| CN103168099A (en) * | 2010-08-25 | 2013-06-19 | 独立行政法人农业生物资源研究所 | Dried hydrogel, dried vitrigel film, and processes for producing these |
| US20120073859A1 (en) * | 2010-09-24 | 2012-03-29 | Freescale Semiconductor, Inc | Polymer core wire |
| US20150148729A1 (en) * | 2013-11-25 | 2015-05-28 | Innfocus, Inc. | Methods, Systems and Devices for Treating Glaucoma |
| CN104610494A (en) * | 2015-02-05 | 2015-05-13 | 中国科学院兰州化学物理研究所 | Preparation method of artificial tube |
| CN109071942A (en) * | 2016-03-03 | 2018-12-21 | 新加坡国立大学 | Multi-functional, flexible and biocompatible elastomer micro-pipe |
| CN109922760A (en) * | 2016-11-10 | 2019-06-21 | 美敦力瓦斯科尔勒公司 | Drug filling bracket and its manufacturing method for anti-hemostatic tube micro-damage |
| CN111361072A (en) * | 2020-03-04 | 2020-07-03 | 上海交通大学 | Non-contact heating type device and method for preparing micron-sized inner-diameter flexible polymer pipe |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113070006A (en) * | 2021-04-12 | 2021-07-06 | 安徽农业大学 | Avermectin micro-droplet preparation device and method based on flow focusing technology |
| CN113769176A (en) * | 2021-08-26 | 2021-12-10 | 海思盖德(苏州)生物医学科技有限公司 | Heparin coating drainage tube for reducing intraocular pressure and preparation method thereof |
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|---|---|
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