CN110524769B - Gel tube preparation device and micron-sized gel tube prepared by same and used for glaucoma drainage - Google Patents
Gel tube preparation device and micron-sized gel tube prepared by same and used for glaucoma drainage Download PDFInfo
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Abstract
The invention provides a gel tube preparation device and a micron-sized gel tube prepared by the gel tube preparation device and used for glaucoma drainage, and relates to the technical field of new medical materials, wherein the gel tube preparation device comprises a gel cavity, a metal wire and a wire drawing device; the gel cavity mainly comprises a gel inner cavity and a heat-preservation outer cavity which are coated inside and outside; meanwhile, the gel cavity is provided with a metal wire inlet and a metal wire outlet, the metal wire enters the gel cavity from the metal wire inlet through a wire drawing device, adheres to gel in the gel cavity and then penetrates out of the center of the metal wire outlet to obtain a metal wire with an outer layer coated with the gel, and the metal wire is drawn out after solidification and forming to prepare a gel tube; in addition, the ratio of the inner diameter of the metal wire outlet to the diameter of the metal wire is 4-2: 1. Compared with the hose prepared by the existing solution adsorption solidification method, the micron-sized gel tube for glaucoma drainage prepared by the preparation device has the advantages of smooth surface and uniform thickness.
Description
Technical Field
The invention relates to the technical field of medical new materials, in particular to a gel tube preparation device and a micron-sized gel tube prepared by the same and used for glaucoma drainage.
Background
Glaucoma is one of three major cases of blindness in humans, with a total incidence of 1% and 2% after age 45. Glaucoma causes abnormally high pressure in the eye, resulting in optic nerve damage. As the patient ages, the intraocular pressure will continue to rise causing continued damage to the optic nerve. The current main treatment method focuses on reducing intraocular pressure, keeping the intraocular pressure within a normal range and ensuring that a patient can keep certain eyesight.
Traditional treatment methods include the use of pharmacological agents to reduce intraocular pressure. However, drug therapy causes many adverse reactions and fails to accurately control intraocular pressure. Moreover, patients often have no semen in the course of drug therapy, which affects the normal life of patients. In addition to drug therapy, glaucoma drainage valve devices are surgically implanted and achieve the effect of lowering intraocular pressure by draining the aqueous humor from the anterior chamber. However, the existing glaucoma drainage valve device has large volume and heavy wound, is easy to cause infection after operation, leaves scar tissues and seriously and even needs secondary operation. Besides the drainage valve device, the metal drainage nail is also a more recent method, however, the metal drainage nail is hard in texture, strong in foreign body sensation and poor in use feeling of patients.
In recent years, some treatment schemes for guiding aqueous humor into a trabecular meshwork by using a micron-sized hose as a glaucoma drainage tube to reduce intraocular pressure have appeared, however, the existing micron-sized hoses are all prepared by using a solution adsorption solidification method, for example, CN107811752A discloses a scheme for preparing a micron-sized hose by adding a tubular template into a chitosan solution and then using a chitosan adsorption solidification method, but the hoses prepared by the scheme have obvious problems of uneven surface and uneven thickness of the hose, and the scheme has complex preparation process, time and labor consumption and poor economy.
Therefore, research and development of a micron-sized gel tube for glaucoma drainage and a preparation device thereof, which have the advantages of simple preparation process, easily controlled flow, smooth surface and uniform thickness, are necessary and urgent for relieving the problems of complicated preparation process, uneven surface and non-uniform thickness of a hose prepared by the conventional coating solidification method.
In view of the above, the present invention is particularly proposed.
Disclosure of Invention
The first purpose of the invention is to provide a gel tube preparation device, and the gel tube prepared by the gel tube preparation device has the advantages of smooth surface and uniform thickness compared with a hose prepared by the existing solution adsorption solidification method.
It is a second object of the present invention to provide a gel tube which is mainly manufactured by the above gel tube manufacturing apparatus.
The third objective of the present invention is to provide a method for preparing a gel tube, which has the advantages of simple preparation process and easily controllable process compared to the existing solution adsorption solidification method.
The fourth purpose of the invention is to provide a micron-sized gel tube for glaucoma drainage, which has the advantages of flat surface and uniform inner and outer diameter, and has inner and outer diameters suitable for the drainage of aqueous humor of glaucoma.
A fifth object of the present invention is to provide a method for preparing a micro-sized gel tube for glaucoma drainage.
The invention provides a gel tube preparation device, which comprises a gel cavity, a metal wire and a wire drawing device, wherein the gel cavity is provided with a plurality of gel holes;
the gel cavity mainly comprises a gel inner cavity and a heat-preservation outer cavity which are coated inside and outside;
the gel tube is characterized in that the gel cavity is provided with a metal wire inlet and a metal wire outlet, the metal wire enters the gel cavity from the metal wire inlet through a wire drawing device, adheres to gel in the gel cavity and then penetrates out of the center of the metal wire outlet to obtain a metal wire with an outer layer coated with the gel, and the metal wire is drawn out after solidification and forming to prepare the gel tube;
the ratio of the inner diameter of the metal wire outlet to the diameter of the metal wire is 4-2: 1.
Further, a gel solution is injected into the gel inner cavity; the heat preservation outer cavity is filled with heat preservation liquid.
Furthermore, the heat-preservation outer cavity is provided with a heat-preservation liquid inlet and a heat-preservation liquid outlet for the flow of the heat-preservation liquid.
Furthermore, the metal wire outlet is communicated with a cooler, the metal wire which penetrates out of the metal wire outlet and is coated with gel on the outer layer extends into the cooler, and the gel adhered to the outer layer of the metal wire is cooled and solidified.
Further, the wire drawing device comprises a wire inlet roller and a guide roller;
the wire feeding roller is used for controlling the direction of the metal wire entering the gel cavity; the guide roller is used for controlling the direction of the metal wire passing out of the cooler;
preferably, the wire drawing device further comprises a winding roller shaft for pulling the metal wire and winding the metal wire which is drawn out by the guide roller and coated with the solidified gel on the outer layer.
The gel tube provided by the invention is mainly prepared by the gel tube preparation device.
Furthermore, the gel tube is mainly made of a high-molecular hydrogel material;
preferably, the gel tube is made primarily of a biocompatible hydrogel material;
more preferably, the gel tube is made mainly of gelatin.
The invention provides a preparation method of the gel tube, which comprises the following steps:
and (2) enabling the metal wire to enter the gel cavity from the metal wire inlet through the wire drawing device, adhering the gel solution of the high-molecular hydrogel material in the gel cavity, then penetrating out of the center of the metal wire outlet to enable the gel solution to be adhered to the surface of the metal wire, then solidifying the metal wire with the gel solution adhered to the surface, and finally drawing out the metal wire to obtain the gel tube.
The invention provides a micron-sized gel tube for glaucoma drainage, which is mainly prepared by the gel tube preparation device;
wherein the inner diameter of a metal wire outlet in the preparation device is 300-1000 μm, and the diameter of the metal wire is 100-500 μm;
the micron-sized gel tube for glaucoma drainage is mainly made of gelatin;
preferably, the inner diameter of the wire outlet in the preparation device is 400 μm and the diameter of the wire is 100 μm.
The invention provides a preparation method of the micron-sized gel tube for glaucoma drainage, which comprises the following steps:
the metal wire enters a gel cavity from a metal wire inlet through a wire drawing device, gelatin solution is adhered to the inner cavity of the gel cavity, and then the metal wire penetrates out of the center of a metal wire outlet, so that the gelatin solution is adhered to the surface of the metal wire, and then the metal wire with the gelatin solution adhered to the surface is sequentially cured, crosslinked and dried; finally, drawing out the metal wire to obtain a micron-sized gel tube for glaucoma drainage;
preferably, the method comprises in particular the steps of:
(a) adding gelatin solution into the gel inner cavity, and injecting heat preservation solution into the heat preservation outer cavity;
(b) enabling the metal wire to enter the gel cavity from the metal wire inlet through the wire drawing device, adhering gelatin solution in the gel cavity, and then penetrating out from the center of the metal wire outlet to obtain the metal wire with the gelatin solution adhered to the surface;
(c) sequentially curing, crosslinking and drying the metal wire with the gelatin solution adhered to the surface in the step (b); finally, drawing out the metal wire to obtain a micron-sized gel tube for glaucoma drainage;
preferably, the concentration of the gelatin is 0.25-0.70 g/ml;
preferably, the heat preservation liquid is water with the temperature of 45-70 ℃;
preferably, the crosslinking agent for crosslinking is a polyaldehyde solution;
more preferably, the cross-linking agent is glutaraldehyde solution with volume mass fraction of 0.5-1%;
preferably, the crosslinking time is 2-24 h;
more preferably, the time of crosslinking is 24 h;
preferably, the drying time is 12-48 h;
more preferably, the drying time is 24 h.
Compared with the prior art, the invention has the beneficial effects that:
the invention provides a gel tube preparation device, which comprises a gel cavity, a metal wire and a wire drawing device; the gel cavity mainly comprises a gel inner cavity and a heat-preservation outer cavity which are coated inside and outside, wherein the gel inner cavity is used for storing gel, and the heat-preservation outer cavity is used for preserving heat so as to prevent the gel from being solidified in the process of preparing the gel tube; meanwhile, the gel cavity is provided with a metal wire inlet and a metal wire outlet, the metal wire enters the gel cavity from the metal wire inlet through a wire drawing device, adheres to gel in the gel cavity and then penetrates out of the center of the metal wire outlet to obtain a metal wire with an outer layer coated with the gel, and the metal wire is drawn out after solidification and forming to prepare a gel tube; in addition, the ratio of the inner diameter of the metal wire outlet to the diameter of the metal wire is 4-2: 1. Through the specific proportion setting of the internal diameter of above-mentioned wire export and wire diameter, can be so that wear out the periphery gel of wire from the wire export and scrape and attach very evenly, the periphery of gel is also comparatively level simultaneously. Therefore, compared with the hose prepared by the existing solution adsorption solidification method, the gel tube prepared by the preparation device has the advantages of smooth surface and uniform thickness.
The gel tube provided by the invention is mainly prepared by the gel tube preparation device. Compared with the hose prepared by the existing solution adsorption solidification method, the gel tube has the advantages of smooth surface and uniform inner and outer diameter.
According to the preparation method of the gel tube, a metal wire enters a gel cavity from a metal wire inlet through a wire drawing device, a gel solution of a high-molecular hydrogel material is adhered in a gel cavity, then the metal wire penetrates out of the center of a metal wire outlet, the gel solution is adhered to the surface of the metal wire, then the metal wire with the gel solution adhered to the surface is solidified, and finally the metal wire is drawn out to obtain the gel tube. Compared with the existing solution adsorption solidification method, the preparation method of the gel tube has the advantages of simple preparation process and easily-controlled flow, and is very suitable for large-scale industrial rapid production.
The micron-sized gel tube for glaucoma drainage provided by the invention is mainly prepared by the gel tube preparation device; wherein the inner diameter of the metal wire outlet in the preparation device is 300-1000 μm, and the diameter of the metal wire is 100-500 μm; the micron-sized gel tube for glaucoma drainage is mainly made of gelatin. The micron-sized gel tube for glaucoma drainage is prepared from the device and the materials, has the advantages of smooth surface and uniform thickness of the inner diameter and the outer diameter, and also has the inner diameter and the outer diameter which are suitable for glaucoma aqueous humor drainage.
According to the preparation method of the micron-sized gel tube for glaucoma drainage, metal wires enter a gel cavity from a metal wire inlet through a wire drawing device, gelatin solution is adhered to the inner cavity of the gel cavity, and then the metal wires penetrate out from the center of a metal wire outlet, so that the gelatin solution is adhered to the surfaces of the metal wires, and then the metal wires with the gelatin solution adhered to the surfaces are sequentially cured, crosslinked and dried; finally, drawing out the metal wire to obtain a micron-sized gel tube for glaucoma drainage; compared with the existing method for preparing glaucoma drainage by using a solution adsorption solidification method, the preparation method has the advantages of simple preparation process and easily controlled flow.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a schematic structural view of a gel tube preparation apparatus provided in embodiment 1 of the present invention.
Icon: 1-gel chamber; 2-a metal wire; 11-wire inlet; 12-wire outlet; 13-gel lumen; 14-a heat-insulating outer cavity; 141-insulation liquid inlet; 142-a heat preservation liquid outlet; 4-a cooler; 3-a wire drawing device; 31-a wire feeding roller; 32-guide rollers; 33-winding roll shaft.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
According to an aspect of the present invention, a gel tube manufacturing apparatus includes a gel chamber 1, a wire 2, and a wire drawing device 3;
the gel cavity 1 mainly comprises a gel inner cavity 13 and a heat-preservation outer cavity 14 which are coated inside and outside;
the gel tube is characterized in that the gel cavity 1 is provided with a metal wire inlet 11 and a metal wire outlet 12, the metal wire 2 enters the gel cavity 1 from the metal wire inlet 11 through the wire drawing device 3, the gel adheres to the gel in the gel inner cavity 13 and then penetrates out of the center of the metal wire outlet 12 to obtain the metal wire 2 coated with the gel on the outer layer, and the metal wire 2 is drawn out after solidification forming to prepare the gel tube;
the ratio of the inner diameter of the metal wire outlet 12 to the diameter of the metal wire 2 is 4-2: 1.
the invention provides a gel tube preparation device, which comprises a gel cavity 1, a metal wire 2 and a wire drawing device 3; the gel cavity 1 mainly comprises a gel inner cavity 13 and a heat-preservation outer cavity 14, wherein the gel inner cavity 13 is used for storing gel, and the heat-preservation outer cavity 14 is used for preserving heat so as to prevent the gel from being solidified in the process of preparing the gel tube; meanwhile, the gel cavity 1 is provided with a metal wire inlet 11 and a metal wire outlet 12, the metal wire 2 enters the gel cavity 1 from the metal wire inlet 11 through the wire drawing device 3, the gel adheres to the gel in the gel inner cavity 13 and then penetrates out of the center of the metal wire outlet 12 to obtain the metal wire 2 coated with the gel on the outer layer, and the metal wire 2 is drawn out after curing and forming to prepare the gel tube; in addition, the ratio of the inner diameter of the metal wire outlet 12 to the diameter of the metal wire 2 is 4-2: 1. through the specific proportion setting of the internal diameter of the metal wire outlet 12 and the diameter of the metal wire 2, the gel at the periphery penetrating out of the metal wire 2 from the metal wire outlet 12 can be scraped evenly, and the periphery of the gel is relatively flat. Therefore, compared with the hose prepared by the existing solution adsorption solidification method, the gel tube prepared by the preparation device has the advantages of smooth surface and uniform thickness.
In a preferred embodiment of the present invention, the gel cavity 13 is filled with a gel solution of a polymer hydrogel material; the heat-preservation outer cavity 14 is filled with heat-preservation liquid.
In a preferred embodiment, the gel cavity 13 is filled with a gel solution of a polymer hydrogel material, and the gel solution is used for further preparing a gel tube; the heat-insulating outer cavity 14 is filled with heat-insulating liquid for heat insulation of gel so as to prevent the gel from solidifying in the process of preparing the gel tube.
In a preferred embodiment of the present invention, the insulating outer chamber 14 is provided with an insulating liquid inlet 141 and an insulating liquid outlet 142 for flowing an insulating liquid.
In a preferred embodiment, the heat-preserving outer chamber 14 is provided with a heat-preserving fluid inlet 141 and a heat-preserving fluid outlet 142 for flowing a heat-preserving fluid to achieve a constant temperature of the heat-preserving fluid and avoid the gel from cooling and solidifying during the preparation of the gel tube.
In a preferred embodiment of the present invention, the wire outlet 12 is connected to a cooler 4, and the wire 2, which is extended out of the wire outlet 12 and coated with gel on the outer layer, is extended into the cooler 4 to cool and solidify the gel adhered to the outer layer of the wire 2.
As a preferred embodiment, the cooler 4 may be a cooling pipe.
In a preferred embodiment of the present invention, the drawing device 3 comprises a wire feeding roller 31 and a guide roller 32;
the wire feeding roller 31 is used for controlling the direction of the metal wire 2 entering the gel cavity 1; the guide roller 32 is used for controlling the direction of the metal wire 2 coming out of the cooler 4;
preferably, the wire feeding roller 31 and the guide roller 32 are on the same horizontal line, so that the wire 2 is in a horizontal state in the gel chamber 1.
In a preferred embodiment of the present invention, the drawing device 3 further includes a winding roller 33 for pulling the wire 2 and winding the wire 2 coated with the solidified gel on the outer layer drawn by the guide roller 32.
According to an aspect of the present invention, a gel tube, which is mainly manufactured by the above gel tube manufacturing apparatus.
The gel tube provided by the invention is mainly prepared by the gel tube preparation device. Compared with the hose prepared by the existing solution adsorption solidification method, the gel tube has the advantages of smooth surface and uniform inner and outer diameter.
In a preferred embodiment of the present invention, the gel tube is made mainly of a polymeric hydrogel material;
as a preferred embodiment, the gel tube is made primarily of gelatin, selected from gelatin derived from pig skin having a gel strength of 170-. The optimal dissolving temperature of the gelatin in the method is 45-60 ℃ hot water for dissolving. Dissolving in hot water, and cooling to obtain gel. The dried gel tube is obtained after drying, the gel tube can absorb water to swell in water, the volume is increased, the self-fixing effect can be achieved, and the gelatin hydrogel has better flexibility.
According to an aspect of the present invention, a method for preparing the above gel tube, the method comprising the steps of:
and (2) enabling the metal wire 2 to enter the gel cavity 1 from the metal wire inlet 11 through the wire drawing device 3, adhering gel solution in the gel cavity 13, then penetrating out of the center of the metal wire outlet 12 to enable the gel solution to adhere to the surface of the metal wire 2, solidifying the metal wire 2 with the gel solution adhering to the surface, and finally drawing out the metal wire 2 to obtain the gel tube.
According to the preparation method of the gel tube, the metal wire 2 enters the gel cavity 1 from the metal wire inlet 11 through the wire drawing device 3, the gel solution of the high-molecular hydrogel material is adhered in the gel inner cavity 13, then the metal wire penetrates out from the center of the metal wire outlet 12, the gel solution is adhered to the surface of the metal wire 2, then the metal wire 2 with the gel solution adhered to the surface is solidified, and finally the metal wire 2 is drawn out to obtain the gel tube. Compared with the existing solution adsorption solidification method, the preparation method of the gel tube has the advantages of simple preparation process and easily-controlled flow, and is very suitable for large-scale industrial rapid production.
According to an aspect of the present invention, a micro-sized gel tube for glaucoma drainage, which is mainly manufactured by the above gel tube manufacturing apparatus;
wherein the inner diameter of a metal wire outlet 12 in the preparation device is 300-1000 μm, and the diameter of a metal wire 2 is 100-500 μm;
the micron-sized gel tube for glaucoma drainage is mainly made of gelatin;
the micron-sized gel tube for glaucoma drainage provided by the invention is mainly prepared by the gel tube preparation device; wherein, the inner diameter of the metal wire outlet 12 in the preparation device is 300-1000 μm, and the diameter of the metal wire 2 is 100-500 μm; the micron-sized gel tube for glaucoma drainage is mainly made of gelatin. The micron-sized gel tube for glaucoma drainage is prepared from the device and the materials, has the advantages of smooth surface and uniform thickness of the inner diameter and the outer diameter, and also has the inner diameter and the outer diameter which are suitable for glaucoma aqueous humor drainage.
In a preferred embodiment of the present invention, when the inner diameter of the wire outlet 12 of the preparation device is 400 μm and the diameter of the wire 2 is 100 μm, the prepared micron-sized gel tube for glaucoma drainage has the best drainage effect.
According to an aspect of the present invention, a method for preparing the above micron-sized gel tube for glaucoma drainage, the method comprising the steps of:
the metal wire 2 enters the gel cavity 1 from the metal wire inlet 11 through the wire drawing device 3, gelatin solution is adhered in the gel cavity 13, then the metal wire penetrates out of the center of the metal wire outlet 12, the gelatin solution is adhered to the surface of the metal wire 2, and then the metal wire 2 with the gelatin solution adhered to the surface is sequentially solidified, crosslinked and dried; finally, drawing out the metal wire 2 to obtain a micron-sized gel tube for glaucoma drainage;
according to the preparation method of the micron-sized gel tube for glaucoma drainage, the metal wire 2 enters the gel cavity 1 from the metal wire inlet 11 through the wire drawing device 3, the gelatin solution is adhered to the inner cavity 13 of the gel, and then the metal wire penetrates out from the center of the metal wire outlet 12, so that the gelatin solution is adhered to the surface of the metal wire 2, and then the metal wire 2 with the gel solution adhered to the surface is sequentially cured, crosslinked and dried; finally, drawing out the metal wire 2 to obtain a micron-sized gel tube for glaucoma drainage; compared with the existing method for preparing glaucoma drainage by using a solution adsorption solidification method, the preparation method has the advantages of simple preparation process and easily controlled flow.
In a preferred embodiment of the present invention, the method specifically comprises the steps of:
(a) adding gelatin solution into the gel inner cavity 13, and injecting heat preservation solution into the heat preservation outer cavity 14;
(b) enabling the metal wire 2 to enter the gel cavity 1 from the metal wire inlet 11 through the wire drawing device 3, adhering gelatin solution in the gel cavity 13, and then penetrating out from the center of the metal wire outlet 12 to obtain the metal wire 2 with the gelatin solution adhered to the surface;
(c) sequentially curing, crosslinking and drying the metal wire 2 with the gelatin solution adhered to the surface in the step (b); finally, drawing out the metal wire 2 to obtain a micron-sized gel tube for glaucoma drainage;
in the above preferred embodiment, the gelatin is used in a concentration of 0.25 to 0.70 g/ml;
in the preferred embodiment, the heat-insulating liquid is water at 45-70 ℃;
in the preferred embodiment, the cross-linking agent is glutaraldehyde solution with volume mass fraction of 0.5-1%;
in the preferred embodiment, the crosslinking time is 2 to 24 hours;
preferably, the time for crosslinking is 24 h.
In the above preferred embodiment, the drying time is 12 to 48 hours.
Preferably, the drying time is 24 h.
The technical solution of the present invention will be further described with reference to the following embodiments and the accompanying drawings.
Example 1
As shown in fig. 1, a gel tube manufacturing apparatus includes a gel chamber 1, a wire 2, and a wire drawing device 3;
the gel cavity 1 mainly comprises a gel inner cavity 13 and a heat-preservation outer cavity 14 which are coated inside and outside;
the gel tube is characterized in that the gel cavity 1 is provided with a metal wire inlet 11 and a metal wire outlet 12, the metal wire 2 enters the gel cavity 1 from the metal wire inlet 11 through the wire drawing device 3, the gel adheres to the gel in the gel inner cavity 13 and then penetrates out of the center of the metal wire outlet 12 to obtain the metal wire 2 coated with the gel on the outer layer, and the metal wire 2 is drawn out after solidification forming to prepare the gel tube;
the ratio of the inner diameter of the metal wire outlet 12 to the diameter of the metal wire 2 is 4-2: 1.
The gel tube preparation device provided by the embodiment comprises a gel cavity 1, a metal wire 2 and a wire drawing device 3; the gel cavity 1 mainly comprises a gel inner cavity 13 and a heat-preservation outer cavity 14, wherein the gel inner cavity 13 is used for storing gel, and the heat-preservation outer cavity 14 is used for preserving heat so as to prevent the gel from being solidified in the process of preparing the gel tube; meanwhile, the gel cavity 1 is provided with a metal wire inlet 11 and a metal wire outlet 12, the metal wire 2 enters the gel cavity 1 from the metal wire inlet 11 through the wire drawing device 3, the gel adheres to the gel in the gel inner cavity 13 and then penetrates out of the center of the metal wire outlet 12 to obtain the metal wire 2 coated with the gel on the outer layer, and the metal wire 2 is drawn out after curing and forming to prepare the gel tube; in addition, the ratio of the inner diameter of the metal wire outlet 12 to the diameter of the metal wire 2 is 4-2: 1. Through the specific proportion setting of the internal diameter of the metal wire outlet 12 and the diameter of the metal wire 2, the gel at the periphery penetrating out of the metal wire 2 from the metal wire outlet 12 can be scraped evenly, and the periphery of the gel is relatively flat. Therefore, compared with the hose prepared by the existing solution adsorption solidification method, the gel tube prepared by the preparation device has the advantages of smooth surface and uniform thickness.
In a preferred embodiment of the present invention, the gel cavity 13 is filled with a gel solution of a polymer hydrogel material, and the gel solution is used for further preparing a gel tube; the heat-insulating outer cavity 14 is filled with heat-insulating liquid for heat insulation of gel so as to prevent the gel from solidifying in the process of preparing the gel tube.
Referring to fig. 1, in a preferred embodiment of the present invention, the insulating outer chamber 14 is provided with an insulating liquid inlet 141 and an insulating liquid outlet 142 for flowing an insulating liquid to achieve a constant temperature of the insulating liquid and avoid cooling and solidification of the gel during the preparation of the gel tube.
Referring to fig. 1, in a preferred embodiment of the present invention, the wire outlet 12 is connected to a cooler 4, and the wire 2, which is coated with gel on the outer layer and extends out of the wire outlet 12, extends into the cooler 4 to cool and solidify the gel adhered to the outer layer of the wire 2.
Preferably, the cooler 4 may be a cooling pipe.
With continued reference to fig. 1, in a preferred embodiment of the invention, the drawing device 3 comprises a wire feeding roller 31 and a guide roller 32; the wire feeding roller 31 is used for controlling the direction of the metal wire 2 entering the gel cavity 1; the guide roller 32 is used for controlling the direction of the metal wire 2 coming out of the cooler 4;
the wire feeding roller 31 and the guide roller 32 are on the same horizontal line, so that the wire 2 is in a horizontal state in the gel chamber 1.
With continued reference to fig. 1, in a preferred embodiment of the present invention, the drawing device 3 further comprises a winding roller 33 for pulling the wire 2 and winding the wire 2 coated with the solidified gel drawn by the guide roller 32.
The concrete working process of the gel tube preparation device of the embodiment is as follows: firstly, adding a gelatin solution into the gel inner cavity 13, and injecting a heat preservation solution into the heat preservation outer cavity 14; and then, the metal wire 2 enters the gel cavity 1 from the metal wire inlet 11 through the wire drawing device 3, a gel solution of a high-molecular hydrogel material is adhered in the gel cavity 13, and then the metal wire passes out of the center of the metal wire outlet 12, so that the gel solution is adhered on the surface of the metal wire 2, then the metal wire 2 with the gel solution adhered on the surface is solidified, and finally the metal wire 2 is drawn out to obtain the gel tube.
Example 2
A micro-sized gel tube for glaucoma drainage, which is manufactured by the gel tube manufacturing apparatus of the above example 1;
wherein the inner diameter of the wire outlet 12 in the preparation device is 400 μm and the diameter of the wire 2 is 100 μm.
The specific preparation steps of the micron-sized gel tube for glaucoma drainage are as follows:
(1) 20g of the gelatin solution was dissolved in 40ml of water and heated to 50 ℃ to dissolve overnight. Adding the dissolved gelatin solution into the gel cavity 1 after ultrasonic defoaming;
(2) before the preparation starts, hot water enters from the heat preservation liquid inlet 141, the temperature of the gelatin solution is kept at about 50 ℃ through the heat preservation outer cavity 14, the gelatin solution is not solidified in the process of preparing the gel tube, and meanwhile, the hot water flows out from the heat preservation liquid outlet 142 to complete the whole hot water circulation;
(3) in the gel tube forming stage, the metal wire 2 passes through the gel cavity 1 through a wire feeding roller 31, passes through a guide roller 32 and is finally wound by a winding roller shaft 33;
the metal wire 2 is adhered with gelatin solution through the surface of the gel inner cavity 13, the outer diameter of the gelatin tube can be controlled through the opening size of the metal wire outlet 12, the inner diameter of the metal wire outlet 12 in the embodiment is 400 micrometers, the diameter of the metal wire 2 adsorbing the gelatin solution determines the inner diameter of the finally molded gelatin tube, the diameter of the metal wire 2 in the embodiment is 100 micrometers, and the metal wire 2 adsorbing the gelatin solution is wound and collected by a winding roller shaft 33 after passing through a guide roller 32 after being solidified through the gel of the cooler 4;
(4) cutting the collected metal wire 2 with the gelatin gel wrapped on the outer layer into 6mm, adding 0.5% of glutaraldehyde by volume mass fraction for crosslinking for 24h, drying for 24h, drawing out the metal wire 2 at the core part after drying is completed, and preparing the micron-sized gel tube with the outer diameter of 400 microns and the inner diameter of 100 microns and used for glaucoma drainage.
Example 3
A micron-sized gel tube for glaucoma drainage is the same as that of example 2 except that the inner diameter of the wire outlet 12 is 300 μm and the diameter of the wire 2 is 100 μm.
Example 4
A micron-sized gel tube for glaucoma drainage is the same as that of example 2 except that the inner diameter of the wire outlet 12 is 500 μm and the diameter of the wire 2 is 100 μm.
Example 5
A micro-sized gel tube for glaucoma drainage, which is manufactured by the gel tube manufacturing apparatus of the above example 1;
wherein the inner diameter of the wire outlet 12 in the preparation device is 400 μm and the diameter of the wire 2 is 100 μm.
The specific preparation steps of the micron-sized gel tube for glaucoma drainage are as follows:
1. dissolving 10g of GelMA solution in 50ml of PBS solution for 24 hours, and adding the dissolved GelMA solution into the gel inner cavity 13 after ultrasonic defoaming.
2. In the gel tube forming stage, the metal wire 2 passes through the gel cavity 1 through the wire inlet roller 31, passes through the guide roller 32 and is finally wound by the winding roller shaft 33. The wire 2 passes through the gel inner cavity 13, the surface is adhered with GelMA solution, the outer diameter of the gel tube can be controlled by the opening size of the wire outlet 12, the inner diameter of the narrowest part of the wire outlet 12 is 400 μm in the embodiment, the wire 2 adsorbing the gelatin solution determines the inner diameter of the finally formed gel tube, and the diameter of the wire 2 is selected to be 100 μm in the embodiment. The wire 2 absorbed with the GelMA solution passes through the gel cavity 1, then passes through the guide roller 32, and then is wound and collected by the winding roller shaft 33.
3. Cutting the collected metal wire 2 with gelatin gel wrapped on the outer layer to 6mm length, and cutting with wavelength of 365nm and light intensity of 10mW/cm2After the ultraviolet light source is cured for 12 hours, the GelMA gel tube with the outer diameter of 400 mu m and the inner diameter of 100 mu m is prepared.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (5)
1. The micron-sized gel tube for glaucoma drainage is characterized in that a preparation device of the gel tube comprises a gel cavity, a cooler, a metal wire and a wire drawing device;
the gel cavity mainly comprises a gel inner cavity and a heat-preservation outer cavity which are coated inside and outside;
the gel tube is characterized in that the gel cavity is provided with a metal wire inlet and a metal wire outlet, the metal wire enters the gel cavity from the metal wire inlet through a wire drawing device, adheres to gel in the gel cavity and then penetrates out of the center of the metal wire outlet to obtain a metal wire with an outer layer coated with the gel, and the metal wire is drawn out after solidification and forming to prepare the gel tube;
the metal wire outlet is communicated with a cooler, the metal wire which penetrates out of the metal wire outlet and is coated with gel on the outer layer extends into the cooler, and the gel adhered to the outer layer of the metal wire is cooled and solidified;
the ratio of the inner diameter of the metal wire outlet to the diameter of the metal wire is 4-2: 1;
the micron-sized gel tube for glaucoma drainage is mainly made of gelatin;
the preparation method of the micron-sized gel tube for glaucoma drainage comprises the following steps:
(a) adding gelatin solution into the gel inner cavity, and injecting heat preservation solution into the heat preservation outer cavity;
the concentration of the gelatin is 0.25-0.70 g/ml; the heat preservation liquid is water with the temperature of 45-70 ℃;
(b) enabling the metal wire to enter the gel cavity from the metal wire inlet through the wire drawing device, adhering gelatin solution in the gel cavity, and then penetrating out from the center of the metal wire outlet to obtain the metal wire with the gelatin solution adhered to the surface;
(c) sequentially curing, crosslinking and drying the metal wire with the gelatin solution adhered to the surface in the step (b); finally, drawing out the metal wire to obtain a micron-sized gel tube for glaucoma drainage;
the cross-linking agent is a glutaraldehyde solution with the volume mass fraction of 0.5-1%;
the crosslinking time is 24 hours; the drying time is 24 h.
2. The micron-sized gel tube for glaucoma drainage according to claim 1, wherein a gel solution of a high molecular hydrogel material is injected into a gel lumen of the preparation device of the gel tube; the heat-insulating liquid is injected into the heat-insulating outer cavity of the preparation device of the gel tube.
3. The micron-sized gel tube for glaucoma drainage according to claim 1 or 2, wherein the insulating outer cavity of the gel tube preparation apparatus is provided with an insulating liquid inlet and an insulating liquid outlet for the flow of an insulating liquid.
4. The micron-sized gel tube for glaucoma drainage according to claim 1, wherein the drawing means of the gel tube preparation apparatus comprises a wire feeding roller and a guide roller;
the wire feeding roller is used for controlling the direction of the metal wire entering the gel cavity; the guide rollers are used to control the direction of the wire passing out of the cooler.
5. The micron-sized gel tube for glaucoma drainage according to claim 4, wherein the drawing means of the gel tube manufacturing apparatus further comprises a winding roller for drawing the wire and winding the wire drawn by the guide roller and coated with the solidified gel.
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| CN113070006A (en) * | 2021-04-12 | 2021-07-06 | 安徽农业大学 | Avermectin micro-droplet preparation device and method based on flow focusing technology |
| CN113769176B (en) * | 2021-08-26 | 2022-07-05 | 海思盖德(苏州)生物医学科技有限公司 | Heparin coating drainage tube for reducing intraocular pressure and preparation method thereof |
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