CN113069542A - 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展 - Google Patents

使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展 Download PDF

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Publication number
CN113069542A
CN113069542A CN202110368292.4A CN202110368292A CN113069542A CN 113069542 A CN113069542 A CN 113069542A CN 202110368292 A CN202110368292 A CN 202110368292A CN 113069542 A CN113069542 A CN 113069542A
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China
Prior art keywords
seq
patient
secukinumab
antibody
antagonist
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Pending
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CN202110368292.4A
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English (en)
Chinese (zh)
Inventor
S·姆珀福
H·理查德斯
G·里戈兹奥
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Novartis AG
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Novartis AG
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54186247&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN113069542(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN113069542A publication Critical patent/CN113069542A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Oncology (AREA)
CN202110368292.4A 2014-09-10 2015-09-08 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展 Pending CN113069542A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462048512P 2014-09-10 2014-09-10
US62/048,512 2014-09-10
CN201580047920.1A CN107073110A (zh) 2014-09-10 2015-09-08 使用il‑17拮抗剂抑制银屑病关节炎患者的结构损伤进展

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201580047920.1A Division CN107073110A (zh) 2014-09-10 2015-09-08 使用il‑17拮抗剂抑制银屑病关节炎患者的结构损伤进展

Publications (1)

Publication Number Publication Date
CN113069542A true CN113069542A (zh) 2021-07-06

Family

ID=54186247

Family Applications (4)

Application Number Title Priority Date Filing Date
CN202110368292.4A Pending CN113069542A (zh) 2014-09-10 2015-09-08 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展
CN202210788000.7A Pending CN115957326A (zh) 2014-09-10 2015-09-08 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展
CN202210786909.9A Pending CN115944734A (zh) 2014-09-10 2015-09-08 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展
CN201580047920.1A Pending CN107073110A (zh) 2014-09-10 2015-09-08 使用il‑17拮抗剂抑制银屑病关节炎患者的结构损伤进展

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN202210788000.7A Pending CN115957326A (zh) 2014-09-10 2015-09-08 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展
CN202210786909.9A Pending CN115944734A (zh) 2014-09-10 2015-09-08 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展
CN201580047920.1A Pending CN107073110A (zh) 2014-09-10 2015-09-08 使用il‑17拮抗剂抑制银屑病关节炎患者的结构损伤进展

Country Status (22)

Country Link
US (2) US11278618B2 (https=)
EP (2) EP3191120B1 (https=)
JP (4) JP2017528465A (https=)
KR (2) KR20230170796A (https=)
CN (4) CN113069542A (https=)
AU (2) AU2015313827C1 (https=)
BR (1) BR112017003332A2 (https=)
CA (1) CA2960754A1 (https=)
DK (1) DK3191120T3 (https=)
ES (1) ES2981697T3 (https=)
FI (1) FI3191120T3 (https=)
HR (1) HRP20240921T1 (https=)
HU (1) HUE067081T2 (https=)
LT (1) LT3191120T (https=)
MX (1) MX2017003216A (https=)
PL (1) PL3191120T3 (https=)
PT (1) PT3191120T (https=)
RS (1) RS65851B1 (https=)
RU (1) RU2697383C2 (https=)
SI (1) SI3191120T1 (https=)
SM (1) SMT202400285T1 (https=)
WO (1) WO2016038538A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2017003216A (es) 2014-09-10 2017-05-23 Novartis Ag Uso de antagonistas de il-17 para inhibir la progresion del daño estructural en pacientes con artritis psoriasica.
MY206805A (en) 2015-10-27 2025-01-08 UCB Biopharma SRL Methods of treatment using anti-il-17a/f antibodies
US10676522B2 (en) * 2017-05-05 2020-06-09 Novartis Ag Methods of selectively treating asthma using IL-17 antagonists
EP3672988A1 (en) * 2017-08-23 2020-07-01 Eli Lilly and Company Treatment of genital psoriasis
WO2019087133A1 (en) * 2017-11-02 2019-05-09 Novartis Ag Method of treating tendinopathy using interleukin-17 (il-17)
MX2021014953A (es) * 2019-06-04 2022-01-24 Janssen Biotech Inc Metodo seguro y eficaz para tratar la artritis psoriasica con el anticuerpo especifico anti-il23.
KR102576258B1 (ko) 2019-12-05 2023-09-11 아주대학교산학협력단 펩타이드 또는 이의 혼합물을 유효성분으로 함유하는 조성물 및 이의 의학적 용도
KR102394378B1 (ko) 2020-10-14 2022-05-03 한림대학교 산학협력단 피부 각질세포에서의 아릴탄화수소 수용체 억제자(AhRR) 과발현 방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0417487D0 (en) * 2004-08-05 2004-09-08 Novartis Ag Organic compound
GB0425569D0 (en) 2004-11-19 2004-12-22 Celltech R&D Ltd Biological products
CN101326195B9 (zh) 2005-12-13 2022-11-11 伊莱利利公司 抗il-17抗体
JP5068270B2 (ja) 2006-01-31 2012-11-07 ノバルティス アーゲー 癌を処置するためのｉｌ−１７アンタゴニスト抗体
GB0612928D0 (en) 2006-06-29 2006-08-09 Ucb Sa Biological products
US7833527B2 (en) 2006-10-02 2010-11-16 Amgen Inc. Methods of treating psoriasis using IL-17 Receptor A antibodies
CA2690568A1 (en) 2007-06-20 2008-12-24 Schering Corporation Joint destruction biomarkers for anti-il-17a therapy of inflammatory joint disease
US7856118B2 (en) 2007-07-20 2010-12-21 The Procter & Gamble Company Methods for recommending a personal care product and tools therefor
JP5581323B2 (ja) 2008-09-29 2014-08-27 ロシュ グリクアート アクチェンゲゼルシャフト ヒトｉｌ１７に対する抗体およびその使用
PH12013500660B1 (en) * 2010-10-08 2017-10-27 Novartis Ag Methods of treating psoriasis using il-17 antagonists
MX362591B (es) * 2010-11-05 2019-01-25 Novartis Ag Uso de antagonistas de il-17.
TW201307845A (zh) 2010-12-13 2013-02-16 Novartis Ag 預測方法及利用ｉｌ－１７拮抗劑治療關節炎的方法
CA2856252A1 (en) * 2011-11-21 2013-05-30 Novartis Ag Methods of treating psoriatic arthritis (psa) using il-17 antagonists and psa response or non-response alleles
CN103936854B (zh) * 2014-04-30 2016-08-17 北京精益泰翔技术发展有限公司 抗il-17a单克隆抗体及其制备与应用
MX2017003216A (es) 2014-09-10 2017-05-23 Novartis Ag Uso de antagonistas de il-17 para inhibir la progresion del daño estructural en pacientes con artritis psoriasica.

Also Published As

Publication number Publication date
US11278618B2 (en) 2022-03-22
HUE067081T2 (hu) 2024-09-28
WO2016038538A1 (en) 2016-03-17
JP7288927B2 (ja) 2023-06-08
FI3191120T3 (fi) 2024-07-10
KR20170045240A (ko) 2017-04-26
JP7591092B2 (ja) 2024-11-27
EP3191120A1 (en) 2017-07-19
CN115957326A (zh) 2023-04-14
SI3191120T1 (sl) 2024-10-30
US20170281762A1 (en) 2017-10-05
LT3191120T (lt) 2024-07-25
HRP20240921T1 (hr) 2024-10-11
SMT202400285T1 (it) 2024-09-16
JP2021152021A (ja) 2021-09-30
AU2015313827B2 (en) 2018-02-15
ES2981697T3 (es) 2024-10-10
AU2018201410A1 (en) 2018-03-22
EP4406969A2 (en) 2024-07-31
US20220313818A1 (en) 2022-10-06
DK3191120T3 (da) 2024-07-15
JP2023109973A (ja) 2023-08-08
JP2025024104A (ja) 2025-02-19
JP2017528465A (ja) 2017-09-28
PT3191120T (pt) 2024-07-16
BR112017003332A2 (pt) 2017-11-28
RU2697383C2 (ru) 2019-08-13
RU2017107501A (ru) 2018-10-10
RU2017107501A3 (https=) 2019-03-12
AU2015313827A1 (en) 2017-02-16
MX2017003216A (es) 2017-05-23
EP3191120B1 (en) 2024-04-10
CN107073110A (zh) 2017-08-18
KR20230170796A (ko) 2023-12-19
AU2015313827C1 (en) 2018-08-30
EP4406969A3 (en) 2024-11-27
PL3191120T3 (pl) 2024-08-26
RS65851B1 (sr) 2024-09-30
CN115944734A (zh) 2023-04-11
CA2960754A1 (en) 2016-03-17

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