CN113069473A

CN113069473A - Plaster prepared from brain-refreshing decoction dregs

Info

Publication number: CN113069473A
Application number: CN202110447157.9A
Authority: CN
Inventors: 毛菊红; 朱音; 王晓霞; 过晓磊
Original assignee: Wuxi Jiyu Shanhe Pharmaceutical Co Ltd
Current assignee: Wuxi Jiyu Shanhe Pharmaceutical Co Ltd
Priority date: 2021-04-24
Filing date: 2021-04-24
Publication date: 2021-07-06
Anticipated expiration: 2041-04-24
Also published as: CN113069473B

Abstract

The invention relates to a plaster prepared from refreshing decoction dregs, wherein the refreshing decoction dregs are fine musk dregs powder obtained by drying, grinding and sieving extracted musk after refreshing decoction is prepared, and the fine musk dregs powder is mixed with other medicines by the inventor to prepare an external preparation for treating skin diseases, joint diseases and the like; the traditional Chinese medicine external preparation is prepared from musk residue fine powder and traditional Chinese medicine raw materials such as pawpaw, large-leaved gentian, radix stephaniae tetrandrae, lycopodium clavatum, angelica dahurica, radix puerariae and Plumbum preparatium powder.

Description

Plaster prepared from brain-refreshing decoction dregs

Technical Field

The invention relates to the field of medicines, relates to application of refreshing decoction dregs, and particularly relates to application of musk decoction dregs.

Background

The injection for refreshment is a Chinese medicinal injection prepared by distilling, extracting and refining musk, borneol, radix curcumae and gardenia by steam, and has the effects of clearing heat and detoxicating, cooling blood and activating blood circulation, and inducing resuscitation and refreshment. The product is prepared by cutting famous traditional Chinese medicine Angong bezoar into pills, wherein the dosage of Moschus is 7.5g, Moschus is distilled and extracted during preparation of injection for refreshing brain, and the detection shows that the final product contains 50% muscone (effective component).

The musk is a dry secretion in mature male sachets of deer-family animals such as forest musk deer, horse musk deer or original musk deer, is a rare traditional Chinese medicinal material, has the effects of inducing resuscitation and refreshing mind, activating blood and stimulating menstrual flow, and relieving swelling and pain, and is clinically used for fever coma, stroke with phlegm syncope, traumatic injury pain, arthralgia, numbness, carbuncle swelling and scrofula and the like.

The Xingnaojing injection is prepared by extracting and processing traditional Chinese medicine components, wherein musk is independently extracted and processed, and the extraction and processing method comprises the following steps: adding Moschus into the distillate of fructus Gardeniae and radix Curcumae, soaking for 1 hr, and distilling. The residue obtained after extraction is usually disposed of as solid waste.

The inventor detects musk dregs, takes musk ketone as a main index, and compares the total amount of the musk ketone after musk distillation extraction with the total amount of the original medicinal material musk ketone through determination to calculate that the transfer rate is about 50 percent, namely about 50 percent of effective components still remain in the dregs. Because musk is precious, the medicine dregs for extracting musk can be reused, which is beneficial to human beings.

After being prepared to restore consciousness and calm, the musk extracted by the inventor is dried, ground and sieved by a 100-mesh sieve to obtain fine powder (yellow brown, powdery) of musk dregs. The inventor mixes the musk decoction dreg fine powder with other medicines to prepare an external preparation for treating skin diseases, joint diseases and the like, and obtains unexpected technical effects.

The external preparation which can be prepared by the invention comprises: musk pain-dispelling aerosol, musk pain-dispelling liniment, musk traumatic injury rheumatism plaster, musk activating liniment and the like.

Preferably, the external preparation of the invention is used for rheumatism, rheumatoid arthritis and other arthralgia diseases, and the clinical manifestations of the diseases are pain, aching and heavy in limbs, bones, joints, muscles and other parts, and even unfavorable flexion and extension of joints, swelling and deformation. The pathogenic factors include wind, cold, dampness, heat, etc. which block the meridians and collaterals, affecting the circulation of qi and blood. Musk has the effects of promoting blood circulation, dredging channels, and relieving swelling and pain. According to the invention, the extracted musk residues are treated to prepare the musk residue fine powder, so that resources are recycled, the maximum development and utilization of the resources are realized, the solid waste treatment cost of enterprises is reduced, and the environmental pollution hazard is reduced.

Disclosure of Invention

The invention provides application of dregs (named as musk dregs fine powder) after musk extraction.

The invention preferably provides a traditional Chinese medicine preparation taking fine musk decoction dregs powder as a raw material.

More preferably, the present invention is characterized in that a residue after extraction of musk (referred to as musk residue fine powder) is used as a raw material of the external preparation of traditional Chinese medicine of the present invention.

The traditional Chinese medicine external preparation is prepared from musk residue fine powder and traditional Chinese medicine raw materials such as pawpaw, large-leaved gentian, radix stephaniae tetrandrae, lycopodium clavatum, angelica dahurica, radix puerariae and Plumbum preparatium powder.

The weight ratio of each component is as follows:

the most preferable weight ratio of each component is as follows:

the invention further provides a preparation method of the traditional Chinese medicine external preparation, which comprises the following steps:

(1) drying Moschus residue at low temperature, and grinding into powder.

(2) Heating vegetable oil or animal oil in a pot, adding 5-10 g of fructus Chaenomelis, 5-10 g of radix Gentianae Macrophyllae, 4-8 g of radix Stephaniae Tetrandrae, 4-8 g of herba Lycopodii, 4-8 g of radix Angelicae Dahuricae, and 4-8 g of radix Puerariae into the hot oil, heating and stirring until the medicinal materials are fried to dark brown surface and brown inside. After frying, hot filtering to obtain medicinal oil for later use.

(3) Decocting the medicinal oil until the medicinal oil can be dripped into bead (dripping medicinal oil into water into bead);

(4) after the medicinal oil is refined, the lead powder (traditional Chinese medicine lead powder, also called yellow lead powder, lead can directly kill bacteria and parasites and has the function of stopping mucus secretion) is added under stirring until the paste is viscous, clear water is sprayed to make the paste into lumps, and the lumps are soaked in the clear water.

(5) Taking out the plaster, placing the plaster in a pot, heating and melting the plaster by small fire, scattering 0.1 to 0.5 g of musk slag powder into the plaster, and uniformly stirring the mixture.

(6) Coating the plaster on a cloth, cutting, and packaging.

The method is obtained by screening, and the screening process is as follows:

selection of first and second mixture ratio

The plaster prepared according to each proportion has good plaster forming effect, moderate viscosity and softening point of 43-55 ℃.

Second, the plaster is tried

After the plaster preparation was completed, a total of 42 people were used for 4 formulations. People who use the medicine for a long time suffer from rheumatism and rheumatoid diseases, and the ache of the affected part is aggravated in rainy days. The plaster is applied to the affected part for about 2 weeks.

Sample (I)	Number of users	Is effective	Wherein the effect is shown	Invalidation	Adverse reaction
						Ratio 1	10 times per human	7 times per man	3 times of a human body	3 times of a human body	Skin rash on the skin of 1 case
Ratio 2	9 times of human being	7 times per man	5 times per man	2 times of a person	Is free of
						Ratio 3	11 times of a human being	11 times of a human being	7 times per man	0 person times	Is free of
Ratio 4	For 12 persons	11 times of a human being	6 times of a human body	1 man times	Itching on the affected part in 2 cases

The product is used for 42 people, the effect is more than 85%, some patients have allergy phenomena such as rash, pruritus and other adverse reactions, and the product is improved after the medicine is stopped.

The plaster prescription belongs to the invention for the first time. In the formula, the musk has the effects of promoting blood circulation, dredging channels, reducing swelling and relieving pain; the pawpaw, the large-leaved gentian, the lycopodium clavatum, the radix stephaniae tetrandrae and the pawpaw are all wind-damp-dispelling medicines and have the effects of relaxing tendons, activating collaterals, dispelling wind and eliminating dampness, wherein the lycopodium clavatum also has the effects of promoting blood circulation, relieving swelling and relieving pain and inducing diuresis. Radix Angelicae Dahuricae and radix Puerariae belong to the channel-guiding drugs of Yangming channel, and radix Puerariae also has effects of relieving muscles and reducing fever. The eight medicinal materials together have the effects of dispelling wind and removing dampness, and relieving dysmenorrhea and pain.

The inventive work of the present invention lies in:

(1) the musk waste residue is recycled in the production process of the Xingnaojing injection preparation for the first time, so that musk resources are saved, the solid waste treatment cost of enterprises is reduced, and energy conservation and environmental protection are realized.

(2) The self-made plaster has simple process operation and good clinical effect.

Detailed Description

The invention is further illustrated, but not limited, by the following specific examples.

Example 1:

(1) drying Moschus residue at low temperature, and grinding into powder.

(2) Heating 500 g of lard in a pot, putting 50 g of pawpaw, 40 g of gentiana macrophylla, 40 g of radix stephaniae tetrandrae, 40 g of lycopodium clavatum, 40 g of angelica dahurica and 40 g of radix puerariae into the hot oil, heating and continuously stirring until the medicine materials are fried to the degree that the surface is dark brown and the inside is scorched. After frying, hot filtering to obtain medicinal oil for later use.

(3) Decocting the above medicinal oil until the medicinal oil can be dripped into bead.

(4) After the medicine oil is refined, 215 g of lead powder is added while stirring until the paste is viscous, clear water is sprayed to form lumps of the paste, and the paste is soaked in the clear water.

(5) Taking out the plaster, placing the plaster in a pot, heating and melting the plaster by soft fire, scattering 1 g of musk slag powder into the plaster, and uniformly stirring the mixture.

(6) 20 g of plaster is evenly coated on plaster cloth (12cm x 10cm) for use.

Example 2:

(1) drying Moschus residue at low temperature, and grinding into powder.

(2) Heating 500 g of lard in a pot, putting 90 g of pawpaw, 90 g of gentiana macrophylla, 60 g of radix stephaniae tetrandrae, 60 g of lycopodium clavatum, 60 g of angelica dahurica and 60 g of radix puerariae into the hot oil, heating and continuously stirring until the medicine materials are fried to the degree that the surface is dark brown and the inside is scorched. After frying, hot filtering to obtain medicinal oil for later use.

(4) After the medicine oil is refined, 240 g of lead powder is added while stirring until the paste is viscous, clear water is sprayed to form lumps of the paste, and the paste is soaked in the clear water.

(5) Taking out the plaster, placing the plaster in a pot, heating and melting the plaster by soft fire, scattering 5g of musk slag powder into the plaster, and uniformly stirring the mixture.

(6) 20 g of plaster is evenly coated on plaster cloth (12cm x 10cm) for use.

Example 3:

(1) drying Moschus residue at low temperature, and grinding into powder.

(2) Heating peanut oil 500 in a pot, adding pawpaw 90 g, large-leaved gentian 90 g, tetrandra root 60 g, buck grass 60 g, dahurian angelica root 60 g and kudzuvine root 60 g into hot oil, heating and stirring continuously until the medicine materials are fried to the degree that the surface is dark brown and the inside is scorched. After frying, hot filtering to obtain medicinal oil for later use.

(4) After the medicine oil is refined, 235 g of lead powder is added while stirring until the paste is viscous, clear water is sprayed to form lumps, and the paste is soaked in clear water.

(6) 20 g of plaster is evenly coated on plaster cloth (12cm x 10cm) for use.

Claims

1. A Chinese medicinal preparation is prepared from fine powder of Moschus residue.

2. The Chinese medicinal preparation according to claim 1, which is an external preparation for treating arthralgia syndrome such as rheumatism and rheumatoid arthritis, and the clinical manifestations of these diseases are pain, soreness and heaviness in limbs, bones, joints and muscles, even difficulty in flexion and extension, swelling and deformation of joints. The pathogenic factors include wind, cold, dampness, heat, etc. which block the meridians and collaterals, affecting the circulation of qi and blood. Musk has the effects of promoting blood circulation, dredging channels, and relieving swelling and pain.

3. The traditional Chinese medicine preparation according to claim 1, comprising: musk pain-dispelling aerosol, musk pain-dispelling liniment, musk traumatic injury rheumatism paste and musk activating liniment.

4. The traditional Chinese medicine preparation of claim 1, wherein the fine musk residue powder is prepared by processing musk residue obtained after extraction of Xingnaojing.

5. The Chinese medicinal preparation of claim 1, which is prepared from fine powders of Moschus residues, and Chinese medicinal materials including fructus Chaenomelis, radix Gentianae Macrophyllae, radix Stephaniae Tetrandrae, herba Lycopodii, radix Angelicae Dahuricae, radix Puerariae, Plumbum Preparatium powder, etc.

6. The traditional Chinese medicine preparation according to claim 1, which comprises the following components in parts by weight:

7. the traditional Chinese medicine preparation according to claim 1, which comprises the following components in parts by weight:

8. the method for preparing the Chinese medicinal preparation of claim 1, which comprises the following steps:

(1) drying Moschus residues at low temperature, and grinding into powder;

(2) heating vegetable oil or animal oil in a pot, adding 5-10 g of fructus Chaenomelis, 5-10 g of radix Gentianae Macrophyllae, 4-8 g of radix Stephaniae Tetrandrae, 4-8 g of herba Lycopodii, 4-8 g of radix Angelicae Dahuricae, and 4-8 g of radix Puerariae into the hot oil, heating and stirring until the medicinal materials are fried to dark brown surface and brown inside. After frying, hot filtering to obtain medicinal oil for later use;

(3) decocting the medicinal oil until the medicinal oil can be dripped into bead;

(4) after the medicinal oil is refined, adding the Plumbum Preparatium powder under stirring until the paste is viscous, spraying clear water, making the paste into lumps, and soaking in clear water;

(5) taking out the plaster, placing the plaster in a pot, heating and melting the plaster by soft fire, scattering 0.1 to 0.5 g of musk slag powder into the plaster, and uniformly stirring the mixture;

(6) coating the plaster on a cloth, cutting, and packaging.