CN102363016A - Traditional Chinese medicine composite dripping core pills and preparation method thereof - Google Patents
Traditional Chinese medicine composite dripping core pills and preparation method thereof Download PDFInfo
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- CN102363016A CN102363016A CN2011103301331A CN201110330133A CN102363016A CN 102363016 A CN102363016 A CN 102363016A CN 2011103301331 A CN2011103301331 A CN 2011103301331A CN 201110330133 A CN201110330133 A CN 201110330133A CN 102363016 A CN102363016 A CN 102363016A
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Abstract
The invention discloses traditional Chinese medicine composite dripping core pills and a preparation method thereof. According to the invention, the dripping core pills are prepared from forest musk, wenchow turmeric root tuber, borneol, common gardenia fruit, and the like. Liposoluble or volatile substances are prepared into dripping pills; the dripping pills are adopted as mother cores; and a water-soluble substance is coated on the mother cores, such that the dripping core pills are formed. With the dripping core pills, advantages of dripping pills and watered pills are combined; defects of dripping pills and watered pills are overcome; usage amount is reduced; dissolution time is shortened; and the preparation form is optimized.
Description
Technical field
The present invention relates generally to medical technical field, is specifically related to a kind of Chinese medicine compound drop pill preparation and preparation method thereof.
Technical background
Drop pill is that fat-soluble or volatile material are processed drop pill, makes parent nucleus with drop pill, is wrapped in the outer bag heart pill that forms to water-soluble substances.Drop pill has been drawn the advantage of the drop pill and the watered pill, has overcome deficiency separately, has reduced consumption, has shortened to dissolve the time of loosing, and dosage form is more optimized.
At present more to the investigative technique of drop pill in the medical research field, but use on the drop pill of compound Chinese medicinal preparation of volatile oil component in many lessly containing, the applicant passes through experimental exploring, finds a kind of new Chinese medicine compound drop pill preparation and preparation method thereof.
Chinese medicine " cow-bezoar bolus for resurrection ", its main component has Moschus, and Borneolum Syntheticum and Radix Curcumae, Fructus Gardeniae have the refreshment relieving convulsion, clearing away heat and cooling blood, promoting flow of QI and blood, the effect of detoxifcation analgesic.Clinically be used to treat cerebrovascular accident, encephalitis B, central nervous system infection, angina pectoris, the disturbance of consciousness that alcohol or drug poisoning etc. cause etc.The main curative effect composition of cow-bezoar bolus for resurrection is that raw material is distilled volatile quintessence oil that the back obtains, and claims volatile oil again, volatile oil be come out with vapor distillation in the Chinese medicine and with the general name of the not miscible volatility oily composition of water.Volatile oil is mixture, and its component is comparatively complicated, is oil-based liquid.
The tradition cow-bezoar bolus for resurrection is a kind of honeyed pill, because dosage form is very large, causes and takes inconvenience; For finding a kind of taking convenience, the cow-bezoar bolus for resurrection novel formulation that curative effect is superior, the present invention is applied to cow-bezoar bolus for resurrection with the drop pill technology; Found preparation of a kind of new cow-bezoar bolus for resurrection and preparation method thereof unexpectedly; And find that unexpectedly it has more superior curative effect, dissolution, stability and adaptability.
Summary of the invention
The present invention mainly overcomes the limitation of prior art, and a kind of preparation and preparation thereof of the Chinese medicine compound drop pill preparation that multiple volatile oil and solid drugs are formed are provided.
Chinese medicine compound drop pill preparation of the present invention is prepared from following Chinese medicine raw materials by weight proportion medicine: 30 parts of Fructus Gardeniaes, 30 parts of Radix Curcumaes, 7.5 parts in Moschus, 1 part of Borneolum Syntheticum.
Chinese medicine compound drop pill preparation of the present invention; It is made up of medicine nuclear and integument, and medicine nuclear is wrapped in the integument, wherein: medicine nuclear is to be processed by volatile oil, Borneolum Syntheticum and the substrate extracted with Fructus Gardeniae, Radix Curcumae, Moschus; Its diameter is the 3-4 millimeter; Integument is to obtain medicinal residues behind Fructus Gardeniae, Radix Curcumae, the extraction volatile oil, processes through extracting the extract and the adjuvant that obtain again, and integument thickness is the 0.5-1 millimeter; Medicine nuclear is pale brown color, and integument is that sepia, preparation are spherosome, diameter is the 5-6 millimeter.
Wherein, The substrate that preparation medicine nuclear uses is water-soluble base or water-insoluble substrate, comprising: polyethylene glycols, polyoxyethylene monostearate class, glycerin gelatine, sodium stearate carbamide, the pool water-insoluble substrate such as water-soluble base, stearic acid, glyceryl monostearate, insect wax, hydrogenated vegetable oil, octadecanol, hexadecanol such as Sha Mu that fall.
The extract of integument can be that Fructus Gardeniae, Radix Curcumae, Moschus are extracted the water extract that the medicinal residues that obtain behind the volatile oil obtain with water extraction, also can be that Fructus Gardeniae, Radix Curcumae, Moschus are extracted the medicinal residues that obtain behind the volatile oil and extract the ethanol extract that obtains with alcohols solvent.
Water extract and ethanol extract are worn into fine powder, are generally the 80-120 order.
Wherein, The adjuvant that uses in the integument comprises starch, dextrin, Icing Sugar, lactose, mannitol, microcrystalline Cellulose, micropowder silica gel, pregelatinized Starch, calcium sulfate, calcium carbonate, calcium hydrogen phosphate, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone, chitin element.
The weight portion ratio of extract and adjuvant is 50-95: 5-50.
The present invention also comprises the method for preparing of Chinese medicine compound drop pill preparation of the present invention, may further comprise the steps:
Step 1 with Fructus Gardeniae, Radix Curcumae, coarse pulverization respectively, is extracted volatile oil, Moschus soaking and extracting volatile oil, and volatile oil mixes, and blended volatile oil and Borneolum Syntheticum mixed dissolution is subsequent use;
Step 2, Fructus Gardeniae, Radix Curcumae, Moschus medicinal residues are used ethanol extraction, and extracting solution reclaims ethanol, gets the ethanol extract thick paste, the decoction of medicinal residues water, decocting liquid is concentrated into thick paste, merges with the ethanol extract thick paste, and the dry extract powder that gets adds the adjuvant mixing, gets mixed powder, and is subsequent use;
Step 3, volatile oil adds the substrate fusion, splashes in the coolant, drips and processes ball, promptly gets drop pill, and drop pill wraps up with mixed powder, promptly gets.
Wherein, the finished product that obtains in the step 3 is used the coating solution coating in case of necessity, gets coating solution.
The method for preparing of preferred Chinese medicine compound drop pill preparation of the present invention may further comprise the steps:
Step 1 becomes fine powder with Fructus Gardeniae, Radix Curcumae, pulverize separately, extracts volatile oil, Moschus soaking and extracting volatile oil, and volatile oil mixes, and blended volatile oil and Borneolum Syntheticum mixed dissolution is subsequent use,
Step 2, Fructus Gardeniae, Radix Curcumae, Moschus medicinal residues be with soak with ethanol 12 hours, the reflux secondary, and each 2 hours, merge reflux extracting liquid, filter; Medicinal residues are subsequent use, and decompression filtrate recycling ethanol to there not being the ethanol flavor, gets the alcohol extraction thick paste, and medicinal residues heating evaporation ethanol makes medicinal residues not have the ethanol flavor; The back decocts twice, and each 1 hour, collecting decoction left standstill, and filters; Filtrate decompression is concentrated into thick paste, merges with the alcohol extraction thick paste, and drying under reduced pressure is ground into 120 order fine powders, gets extract powder; Add low-substituted hydroxypropyl cellulose, addition is an extract powder and low-substituted hydroxypropyl cellulose mixes 7% of the mixed powder gross weight that obtains, and mix homogeneously must mixed powder, and is subsequent use:
Step 3, the polyethylene glycol 6000 that takes by weighing the volatile oil doubling dose of mixed dissolution fully stirs 60～100 ℃ of water-baths, to there not being bubble; Fusion fully places 49～60 ℃ of water-baths then, will extract blended volatile oil and add; Fully stir, finish full-fusing to depletion of QI, splash into temperature and be in 0～5 ℃ the liquid paraffin; Drip and process ball, promptly get drop pill, diameter 4mm; Wipe drop pill surface liquid paraffin, place in the coating pan, the coating kettle temperature is controlled to be 50～60 ℃; The alcoholic solution of sprinkling 85% is sprinkled into the mixed powder that step 2 obtains as wetting agent, and pill is increased; Powder to be mixed is finished using, and the about 6mm of diameter sprays Opadry solution; Coating promptly gets product.
Wherein blended volatile oil is meant the mixture of Fructus Gardeniae volatile oil, Radix Curcumae volatile oil, Moschus volatile oil; Essential oil extraction method also can adopt following method: take by weighing 300 parts of Fructus Gardeniaes, 300 parts of Radix Curcumaes, 75 parts in Moschus; Obtain the mixture of multiple volatile oil through supercritical extraction, the control extracting pressure is 20-45MP, 40 ℃-60 ℃ of extraction temperature; Resolve pressure 10-30MP, 10 ℃-20 ℃ of resolution temperatures;
Above-mentioned Borneolum Syntheticum uses and need meet the pharmacopeia regulation, and mixture of volatile oil and Borneolum Syntheticum weight ratio are preferably 3: 1, dissolve jointly with mixture of volatile oil and substrate.
A kind of Chinese medicine compound drop pill preparation that the present invention is prepared at field of medicaments important advantage and wide prospect are arranged, mainly show the following aspects:
1. raw material is through modern extraction technique, and extraction efficiency is faster, and active constituents of medicine purity is higher, saves material cost.
2. extracts active ingredients is complete, and the adjuvant amount is few, and unit volume drug effective ingredient is many, and volatile ingredient is not volatile, and medicine stability is good.
3. drop pill is molten rapidly diffusing, is prone to absorb, acts on soon, and bioavailability is high.
4. the present invention prepares drop pill technology simply, rationally, and is low for equipment requirements, can reduce production costs greatly, alleviates environmental pollution, is suitable for large-scale industrial production.
In order to confirm Chinese medicine compound drop pill preparation effectiveness, we have carried out relevant experiment, prove the effectiveness of Chinese medicine compound drop pill preparation simultaneously.
(1). two kinds of pill preparations
Getting Fructus Gardeniae is 600g, Radix Curcumae 600g, Moschus 150g, Borneolum Syntheticum 20g, gets the multiple volatile oil device collection in addition of Fructus Gardeniae, Radix Curcumae, Moschus extraction, and blended volatile oil and Borneolum Syntheticum mixed dissolution is subsequent use, and it is subsequent use that medicinal residues prepare extract powder according to method for preparing among the embodiment 1,
1. drop pill preparation
Get above-mentioned volatile oil and extract powder, prepare drop pill according to the method for preparing of embodiment 1.
2. drop pill preparation
Get the volatile oil of mixed dissolution and the polyethylene glycol 6000 of 3 times of amounts of extract powder and fully stir 60～100 ℃ of water-baths, to there not being bubble, fusion fully places 49～60 ℃ of water-baths then, splashes into temperature and is in 0～5 ℃ the liquid paraffin, drips and processes ball, promptly gets drop pill.
(2) two kinds of dosage forms are dissolved the time experiment of loosing relatively
1. dissolve scattered time limit is measured: the dissolve scattered time limit method inspection technique according to Pharmacopoeia of the People's Republic of China appendix XII A is carried out.Get each 6 of above-mentioned two kinds of pill test samples, check according to method.
The dissolve scattered time limit experimental data
Experiment shows: drop pill is all dissolvings in 20 minutes, and drop pill surpasses 50 minutes at whole dissolution times, explain drop pill dissolve loose fast, be prone to absorb, rapid-action, effect is by force.
The comparison of (two) two kinds of pill dissolutions
Dissolution determination: get each 6 of above-mentioned two kinds of pills; According to Pharmacopoeia of the People's Republic of China appendix XC first method; Be dissolution medium with 900mL distilled water, pH6.8 buffer and 0.1mol/L hydrochloric acid respectively; Rotating speed 100r/min, and use Self-control method respectively at 5,10,15,20,30,40,60, calculate the muscone dissolution of two kinds of pills.(seeing the comparison diagram of two kinds of pill dissolutions)
Experimental result shows: drop pill dissolution in the time of 15 minutes can reach 90%, and drop pill is dissolution less than 70% in 40 minutes, and the dissolution that drop pill is described is apparently higher than drop pill.
Description of drawings
The comparison diagram of Fig. 1 drop pill of the present invention and two kinds of pill dissolutions of drop pill, wherein upper curve is a drop pill dissolution curve of the present invention, lower curve is a drop pill dissolution curve.
The specific embodiment
Embodiment 1
Prescription: 300 parts of Radix Curcumaes, 300 parts of Fructus Gardeniaes, 75 parts in Moschus, 10 parts of Borneolum Syntheticums
With Fructus Gardeniae, Radix Curcumae, coarse pulverization respectively, extract volatile oil, Moschus soaking and extracting volatile oil, multiple volatile oil device are in addition collected mixing, and blended volatile oil and Borneolum Syntheticum mixed dissolution is subsequent use, and medicinal residues are subsequent use; Medicinal residues adopted soak with ethanol 12 hours, the reflux secondary, and each 2 hours, merge reflux extracting liquid, filter; Medicinal residues are subsequent use, and decompression filtrate recycling ethanol to there not being the ethanol flavor, gets the alcohol extraction thick paste, medicinal residues heating evaporation ethanol; Make medicinal residues not have the ethanol flavor, the back decocts twice, and each 1 hour, collecting decoction left standstill; Filter, filtrate decompression is concentrated into thick paste, merges with the alcohol extraction thick paste, and drying under reduced pressure is ground into 120 order fine powders; Get extract powder, add low-substituted hydroxypropyl cellulose 7g, mix homogeneously gets mixed powder, and subsequent use: the polyethylene glycol 6000 that takes by weighing the volatile oil doubling dose of mixed dissolution fully stirs 60～100 ℃ of water-baths; To there not being bubble, fusion fully places 49～60 ℃ of water-baths then, will extract blended volatile oil and add, and fully stirs; Finish full-fusing to depletion of QI, splash into temperature and be in 0～5 ℃ the liquid paraffin, drip and process ball, promptly get about 2000 of drop pill, diameter 3mm; Wipe drop pill surface liquid paraffin, place in the coating pan, the coating kettle temperature is controlled to be 50～60 ℃, and the alcoholic solution of sprinkling 85% is as wetting agent; Be sprinkled into mixed powder, pill is increased, powder to be mixed is finished using, the about 6mm of diameter; Spray Opadry solution, coating promptly gets product.
Embodiment 2
Prescription: 300 parts of Radix Curcumaes, 300 parts of Fructus Gardeniaes, 75 parts in Moschus, 10 parts of Borneolum Syntheticums
With Fructus Gardeniae, Radix Curcumae, coarse pulverization respectively, extract volatile oil, Moschus soaking and extracting volatile oil, multiple volatile oil device are in addition collected mixing, and blended volatile oil and Borneolum Syntheticum mixed dissolution is subsequent use, and medicinal residues are subsequent use; Medicinal residues adopted soak with ethanol 12 hours, the reflux secondary, and each 2 hours, merge reflux extracting liquid, filter; Medicinal residues are subsequent use, and decompression filtrate recycling ethanol to there not being the ethanol flavor, gets the alcohol extraction thick paste, medicinal residues heating evaporation ethanol; Make medicinal residues not have the ethanol flavor, the back decocts twice, and each 1 hour, collecting decoction left standstill; Filter, filtrate decompression is concentrated into thick paste, merges with the alcohol extraction thick paste, and drying under reduced pressure is ground into 120 order fine powders; Get extract powder, add carboxymethyl starch sodium 7g, mix homogeneously gets mixed powder, and subsequent use: the polyethylene glycol 6000 that takes by weighing 5.0 times of amounts of volatile oil of mixed dissolution fully stirs 60～100 ℃ of water-baths; To there not being bubble, fusion fully places 49～60 ℃ of water-baths then, will extract blended volatile oil and add, and fully stirs; Finish full-fusing to depletion of QI, splash into temperature and be in 0～5 ℃ the liquid paraffin, collect drop pill, promptly get drop pill, diameter 4mm with dimethicone; Wipe the drop pill dimethicone, place in the coating pan, the coating kettle temperature is controlled to be 50～60 ℃; Spray 3% Eudragit E solution,, be sprinkled into mixed powder as wetting agent; Pill is increased, and powder to be mixed is finished using, the about 6mm of diameter; Spray 3% Eudragit E solution, coating promptly gets product.
Embodiment 3
Prescription: 300 parts of Radix Curcumaes, 300 parts of Fructus Gardeniaes, 75 parts in Moschus, 10 parts of Borneolum Syntheticums
With Fructus Gardeniae, Radix Curcumae, coarse pulverization respectively, extract volatile oil, Moschus soaking and extracting volatile oil, multiple volatile oil device are in addition collected mixing, and blended volatile oil and Borneolum Syntheticum mixed dissolution is subsequent use, and medicinal residues are subsequent use; Medicinal residues adopted soak with ethanol 12 hours, the reflux secondary, and each 2 hours, merge reflux extracting liquid, filter; Medicinal residues are subsequent use, and decompression filtrate recycling ethanol to there not being the ethanol flavor, gets the alcohol extraction thick paste, medicinal residues heating evaporation ethanol; Make medicinal residues not have the ethanol flavor, the back decocts twice, and each 1 hour, collecting decoction left standstill; Filter, filtrate decompression is concentrated into thick paste, merges with the alcohol extraction thick paste, and drying under reduced pressure is ground into 120 order fine powders; Get extract powder, add carboxymethyl cellulose sodium 7g, mix homogeneously gets mixed powder, and subsequent use: the polyethylene glycol 6000 that takes by weighing 5.0 times of amounts of volatile oil of mixed dissolution fully stirs 60～100 ℃ of water-baths; To there not being bubble, fusion fully places 49～60 ℃ of water-baths then, will extract blended volatile oil and add, and fully stirs; Finish full-fusing to depletion of QI, splash into temperature and be in 0～5 ℃ the liquid paraffin, collect drop pill, promptly get drop pill, diameter 4mm with dimethicone; Wipe the drop pill dimethicone, place in the coating pan, the coating kettle temperature is controlled to be 50～60 ℃, sprays ethanol, and pill is increased, and powder to be mixed is finished using, and the about 6mm of diameter sprays 3% Eudragit E solution, and coating promptly gets product.
Claims (10)
1. Chinese medicine compound drop pill preparation, be prepared from following Chinese medicine raw materials by weight proportion medicine: 30 parts of Fructus Gardeniaes, 30 parts of Radix Curcumaes, 7.5 parts in Moschus, 1 part of Borneolum Syntheticum is characterized in that; Wherein said Chinese medicine compound drop pill preparation, it is made up of medicine nuclear and integument, and medicine nuclear is wrapped in the integument; Wherein: medicine nuclear is to be processed by volatile oil, Borneolum Syntheticum and the substrate extracted with Fructus Gardeniae, Radix Curcumae, Moschus; Integument is to obtain medicinal residues behind Fructus Gardeniae, Radix Curcumae, the Moschus extraction volatile oil, processes through extracting the extract and the adjuvant that obtain again, and integument thickness is 0.5 millimeter; Medicine nuclear is pale brown color, and integument is that sepia, preparation are spherosome, diameter is the 5-6 millimeter.
2. according to the preparation of claim 1; It is characterized in that; The substrate that wherein said preparation medicine nuclear uses is water-soluble base or water-insoluble substrate; Comprise: polyethylene glycols, polyoxyethylene monostearate class, glycerin gelatine, sodium stearate carbamide, the pool water-insoluble substrate such as water-soluble base, stearic acid, glyceryl monostearate, insect wax, hydrogenated vegetable oil, octadecanol, hexadecanol such as Sha Mu that fall, the weight portion ratio of extract and adjuvant is 50-95: 5-50.
3. according to the preparation of claim 1; It is characterized in that; The adjuvant that uses in the wherein said integument comprises starch, dextrin, Icing Sugar, lactose, mannitol, microcrystalline Cellulose, micropowder silica gel, pregelatinized Starch, calcium sulfate, calcium carbonate, calcium hydrogen phosphate, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone, chitin element.
4. according to the preparation of claim 1; It is characterized in that; The extract of wherein said integument can be that Fructus Gardeniae, Radix Curcumae, Moschus are extracted the water extract that the medicinal residues that obtain behind the volatile oil obtain with water extraction; Also can be that the medicinal residues that obtain behind Fructus Gardeniae, Radix Curcumae, the Moschus extraction volatile oil extract the ethanol extract that obtains with alcohols solvent, wherein said water extract and ethanol extract be worn into fine powder, are generally the 80-120 order.
5. the method for preparing of preparation according to claim 1 is characterized in that, may further comprise the steps:
Step 1 with Fructus Gardeniae, Radix Curcumae, coarse pulverization respectively, is extracted volatile oil, Moschus soaking and extracting volatile oil, and volatile oil mixes, and blended volatile oil and Borneolum Syntheticum mixed dissolution is subsequent use;
Step 2, Fructus Gardeniae, Radix Curcumae, Moschus medicinal residues are used ethanol extraction, and extracting solution reclaims ethanol, gets the ethanol extract thick paste, the decoction of medicinal residues water, decocting liquid is concentrated into thick paste, merges with the ethanol extract thick paste, and the dry extract powder that gets adds the adjuvant mixing, gets mixed powder, and is subsequent use;
Step 3, volatile oil adds the substrate fusion, splashes in the coolant, drips and processes ball, promptly gets drop pill, and drop pill wraps up with mixed powder, promptly gets.
6. method for preparing according to claim 5 is characterized in that, wherein, the finished product that obtains in the step 3 is used the coating solution coating in case of necessity, gets coating solution.
7. method for preparing according to claim 5 is characterized in that, may further comprise the steps:
Step 1 with Fructus Gardeniae, Radix Curcumae, coarse pulverization respectively, is extracted volatile oil, Moschus soaking and extracting volatile oil, and volatile oil mixes, and blended volatile oil and Borneolum Syntheticum mixed dissolution is subsequent use,
Step 2, Fructus Gardeniae, Radix Curcumae, Moschus medicinal residues be with soak with ethanol 12 hours, the reflux secondary, and each 2 hours, merge reflux extracting liquid, filter; Medicinal residues are subsequent use, and decompression filtrate recycling ethanol to there not being the ethanol flavor, gets the alcohol extraction thick paste, and medicinal residues heating evaporation ethanol makes medicinal residues not have the ethanol flavor; The back decocts twice, and each 1 hour, collecting decoction left standstill, and filters; Filtrate decompression is concentrated into thick paste, merges with the alcohol extraction thick paste, and drying under reduced pressure is ground into 120 order fine powders, gets extract powder; Add low-substituted hydroxypropyl cellulose, addition is an extract powder and low-substituted hydroxypropyl cellulose mixes 7% of the mixed powder gross weight that obtains, and mix homogeneously must mixed powder, and is subsequent use:
Step 3, the polyethylene glycol 6000 that takes by weighing the volatile oil doubling dose of mixed dissolution fully stirs 60～100 ℃ of water-baths, to there not being bubble; Fusion fully places 49～60 ℃ of water-baths then, will extract blended volatile oil and add; Fully stir, finish full-fusing to depletion of QI, splash into temperature and be in 0～5 ℃ the liquid paraffin; Drip and process ball, promptly get drop pill, diameter 2mm; Wipe drop pill surface liquid paraffin, place in the coating pan, the coating kettle temperature is controlled to be 50～60 ℃; The alcoholic solution of sprinkling 85% is sprinkled into the mixed powder that step 2 obtains as wetting agent, and pill is increased; Powder to be mixed is finished using, and the about 10mm of diameter sprays Opadry solution; Coating promptly gets product.
8. method for preparing according to claim 5 is characterized in that, wherein blended volatile oil is meant the mixture of Fructus Gardeniae volatile oil, Radix Curcumae volatile oil, Moschus volatile oil; Essential oil extraction method also can adopt following method: take by weighing 300 parts of Fructus Gardeniaes, 300 parts of Radix Curcumaes, 75 parts in Moschus; Obtain the mixture of multiple volatile oil through supercritical extraction, the control extracting pressure is 20-45MP, 40 ℃-60 ℃ of extraction temperature; Resolve pressure 10-30MP, 10 ℃-20 ℃ of resolution temperatures.
9. method for preparing according to claim 5 is characterized in that, above-mentioned Borneolum Syntheticum uses and need meet the pharmacopeia regulation, and mixture of volatile oil and Borneolum Syntheticum weight ratio are preferably 3: 1, dissolve jointly with mixture of volatile oil and substrate.
10. method for preparing according to claim 5 is characterized in that, prescription: 300 parts of Radix Curcumaes; 300 parts of Fructus Gardeniaes, 75 parts in Moschus, 10 parts of Borneolum Syntheticums are with Fructus Gardeniae, Radix Curcumae, coarse pulverization respectively; Extract volatile oil, Moschus soaking and extracting volatile oil, multiple volatile oil device are in addition collected mixing; Blended volatile oil and Borneolum Syntheticum mixed dissolution is subsequent use, and medicinal residues are subsequent use; Medicinal residues adopted soak with ethanol 12 hours, the reflux secondary, and each 2 hours, merge reflux extracting liquid, filter, medicinal residues are subsequent use; Decompression filtrate recycling ethanol to there not being the ethanol flavor, gets the alcohol extraction thick paste, and medicinal residues heating evaporation ethanol makes medicinal residues not have the ethanol flavor; The back decocts twice, and each 1 hour, collecting decoction left standstill, and filters; Filtrate decompression is concentrated into thick paste, merges with the alcohol extraction thick paste, and drying under reduced pressure is ground into 120 order fine powders, gets extract powder; Add low-substituted hydroxypropyl cellulose, addition is an extract powder and low-substituted hydroxypropyl cellulose mixes 7% of the mixed powder gross weight that obtains, and mix homogeneously must mixed powder, and subsequent use: the polyethylene glycol 6000 that takes by weighing the volatile oil doubling dose of mixed dissolution fully stirs 60～100 ℃ of water-baths; To there not being bubble, fusion fully places 49～60 ℃ of water-baths then, will extract blended volatile oil and add, and fully stirs; Finish full-fusing to depletion of QI, splash into temperature and be in 0～5 ℃ the liquid paraffin, drip and process ball, promptly get drop pill, diameter 3mm; Wipe drop pill surface liquid paraffin, place in the coating pan, the coating kettle temperature is controlled to be 50～60 ℃, and the alcoholic solution of sprinkling 85% is as wetting agent; Be sprinkled into mixed powder, pill is increased, powder to be mixed is finished using, the about 6mm of diameter; Spray Opadry solution, coating promptly gets product.
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| CN113069473B (en) * | 2021-04-24 | 2023-08-11 | 无锡济煜山禾药业股份有限公司 | Plaster prepared from medicinal residues for refreshment |
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Address after: 214028 Changjiang South Road, new Wu District, Wuxi, Jiangsu Province, No. 12 Patentee after: Wuxi Jiyu Shanhe Pharmaceutical Co., Ltd Address before: 214028 No. 12 Changjiang South Road, New District, Jiangsu, Wuxi Patentee before: WUXI JIMIN KEXIN SHANHE PHARMACEUTICAL Co.,Ltd. |