CN113056675A - 用于对具有感染性疾病症状的患者的需要住院的医学状况的风险进行预后的pro-ADM - Google Patents
用于对具有感染性疾病症状的患者的需要住院的医学状况的风险进行预后的pro-ADM Download PDFInfo
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
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- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
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- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
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- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18188098.0 | 2018-08-08 | ||
| EP18188098 | 2018-08-08 | ||
| EP18200907.6A EP3608673A1 (en) | 2018-08-08 | 2018-10-17 | Pro-adm for prognosing the risk of a medical condition requiring hospitalization in patients with symptoms of infectious disease |
| EP18200907.6 | 2018-10-17 | ||
| PCT/EP2019/071334 WO2020030745A1 (en) | 2018-08-08 | 2019-08-08 | Pro-adm for prognosing the risk of a medical condition requiring hospitalization in patients with symptoms of infectious disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113056675A true CN113056675A (zh) | 2021-06-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201980052326.XA Pending CN113056675A (zh) | 2018-08-08 | 2019-08-08 | 用于对具有感染性疾病症状的患者的需要住院的医学状况的风险进行预后的pro-ADM |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20210293830A1 (https=) |
| EP (2) | EP3608673A1 (https=) |
| JP (2) | JP7402858B2 (https=) |
| CN (1) | CN113056675A (https=) |
| BR (1) | BR112021002281A2 (https=) |
| CA (1) | CA3108835A1 (https=) |
| WO (1) | WO2020030745A1 (https=) |
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| US20210285949A1 (en) * | 2020-03-16 | 2021-09-16 | Sphingotec Gmbh | Pro-adrenomedullin or fragment thereof in patients infected with corona virus and treatments with binder against adrenomedullin |
| EP4133274A1 (en) * | 2020-04-06 | 2023-02-15 | B.R.A.H.M.S GmbH | Pro-adrenomedullin for prognosing disease progression in severe acute respiratory syndrome (sars) |
| CN116525105B (zh) * | 2023-06-29 | 2023-10-03 | 中国人民解放军总医院 | 一种心源性休克预后预测预警系统、设备及可存储介质 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104067130A (zh) * | 2011-11-16 | 2014-09-24 | 斯弗因高泰克有限公司 | 肾上腺髓质素测定与用于确定成熟肾上腺髓质素的方法 |
| WO2017089474A1 (en) * | 2015-11-27 | 2017-06-01 | Brahms Gmbh | MR-proADM AS MARKER FOR THE EXTRACELLULAR VOLUME STATUS OF A SUBJECT |
| CN107085114A (zh) * | 2008-10-07 | 2017-08-22 | B.R.A.H.M.S有限公司 | 用于预测初次不利事件的生物标志物 |
| CA3033102A1 (en) * | 2016-08-09 | 2018-02-15 | B.R.A.H.M.S Gmbh | Histones and/or proadm as markers indicating organ dysfunction |
| WO2018029214A1 (en) * | 2016-08-09 | 2018-02-15 | B.R.A.H.M.S Gmbh | Histones and/or proadm as markers indicating an adverse event |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2570703B1 (fr) | 1984-09-26 | 1988-07-08 | Commissariat Energie Atomique | Complexes macropolycycliques de terres rares et application a titre de marqueurs fluorescents |
| US4882733A (en) | 1987-03-13 | 1989-11-21 | Ford Aerospace Corporation | Method and apparatus for combining encoding and modulation |
| FR2664699B1 (fr) | 1990-07-13 | 1995-08-18 | Cis Bio Int | Procede d'amplification du signal d'emission d'un compose luminescent. |
| DE10316583A1 (de) * | 2003-04-10 | 2004-10-28 | B.R.A.H.M.S Aktiengesellschaft | Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung |
| ES2300681T3 (es) * | 2004-07-22 | 2008-06-16 | Brahms Aktiengesellschaft | Procedimiento para el diagnostico y tratamiento de pacientes criticos con endotelina, agonistas de endotelina y antagonistas de adrenomedulina. |
| EP2438447B1 (en) * | 2009-06-05 | 2015-02-18 | B.R.A.H.M.S GmbH | Detection of bacterial infections in subjects suffering from dyspnea. |
| WO2012059477A1 (en) * | 2010-11-01 | 2012-05-10 | B.R.A.H.M.S Gmbh | Prognosis and risk assessment of patients with non-specific complaints |
| EP4231018A3 (en) * | 2016-07-08 | 2023-11-15 | SphingoTec GmbH | Adrenomedullin for assessing congestion in a subject with acute heart failure |
-
2018
- 2018-10-17 EP EP18200907.6A patent/EP3608673A1/en not_active Withdrawn
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2019
- 2019-08-08 CA CA3108835A patent/CA3108835A1/en active Pending
- 2019-08-08 JP JP2021506950A patent/JP7402858B2/ja active Active
- 2019-08-08 WO PCT/EP2019/071334 patent/WO2020030745A1/en not_active Ceased
- 2019-08-08 CN CN201980052326.XA patent/CN113056675A/zh active Pending
- 2019-08-08 BR BR112021002281-3A patent/BR112021002281A2/pt unknown
- 2019-08-08 EP EP19749736.5A patent/EP3833979A1/en active Pending
- 2019-08-08 US US17/266,243 patent/US20210293830A1/en active Pending
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2023
- 2023-12-11 JP JP2023208353A patent/JP2024023615A/ja not_active Abandoned
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107085114A (zh) * | 2008-10-07 | 2017-08-22 | B.R.A.H.M.S有限公司 | 用于预测初次不利事件的生物标志物 |
| CN104067130A (zh) * | 2011-11-16 | 2014-09-24 | 斯弗因高泰克有限公司 | 肾上腺髓质素测定与用于确定成熟肾上腺髓质素的方法 |
| WO2017089474A1 (en) * | 2015-11-27 | 2017-06-01 | Brahms Gmbh | MR-proADM AS MARKER FOR THE EXTRACELLULAR VOLUME STATUS OF A SUBJECT |
| CN108291918A (zh) * | 2015-11-27 | 2018-07-17 | B.R.A.H.M.S 有限公司 | 作为对象的细胞外容量状态的标志物的MR-proADM |
| CA3033102A1 (en) * | 2016-08-09 | 2018-02-15 | B.R.A.H.M.S Gmbh | Histones and/or proadm as markers indicating organ dysfunction |
| WO2018029214A1 (en) * | 2016-08-09 | 2018-02-15 | B.R.A.H.M.S Gmbh | Histones and/or proadm as markers indicating an adverse event |
Non-Patent Citations (2)
| Title |
|---|
| ALBRICH等: "Enhancement of CURB65 score with proadrenomedullin (CURB65-A) for outcome prediction in lower respiratory tract infections: Derivation of a clinical algorithm", BMC INFECTIOUS DISEASES, vol. 11, no. 112, pages 1 - 12, XP021099852, DOI: 10.1186/1471-2334-11-112 * |
| SPOTO等: "Procalcitonin and MR-Proadrenomedullin Combination with SOFA and qSOFA Scores for Sepsis Diagnosis and Prognosis: A Diagnostic Algorithm", SHOCK, vol. 50, no. 1, pages 44 - 52 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021534385A (ja) | 2021-12-09 |
| JP7402858B2 (ja) | 2023-12-21 |
| US20210293830A1 (en) | 2021-09-23 |
| JP2024023615A (ja) | 2024-02-21 |
| EP3608673A1 (en) | 2020-02-12 |
| EP3833979A1 (en) | 2021-06-16 |
| BR112021002281A2 (pt) | 2021-05-04 |
| CA3108835A1 (en) | 2020-02-13 |
| WO2020030745A1 (en) | 2020-02-13 |
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