CN113018356A - Compound essence and preparation method thereof - Google Patents

Compound essence and preparation method thereof Download PDF

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CN113018356A
CN113018356A CN202110327633.3A CN202110327633A CN113018356A CN 113018356 A CN113018356 A CN 113018356A CN 202110327633 A CN202110327633 A CN 202110327633A CN 113018356 A CN113018356 A CN 113018356A
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essential oil
parts
oil
compound essence
traditional chinese
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邱志国
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Hangzhou Hongguo Technology Co ltd
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Hangzhou Hongguo Technology Co ltd
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to compound essence and a preparation method thereof. The compound essence comprises base oil and Chinese medicinal essential oil, wherein the base oil is one of olive oil, aloe oil and apricot kernel oil; the Chinese medicinal essential oil comprises Carthami flos essential oil, Olibanum essential oil, dens Draconis essential oil, Succinum essential oil, Ginseng radix essential oil, radix Angelicae sinensis essential oil, fructus Lycii essential oil, semen Ziziphi Spinosae essential oil, semen Strychni essential oil, and radix Cyathulae essential oil; the invention also provides a preparation method of the compound essence, which comprises the steps of precooling and freeze-drying the traditional Chinese medicine raw materials, then crushing the traditional Chinese medicine raw materials, and respectively carrying out supercritical extraction after crushing; collecting the obtained essential oil, mixing to obtain Chinese medicinal essential oil, and mixing the base oil and the Chinese medicinal essential oil. The compound essence can be used for treating various diseases such as rheumatism, insomnia and the like, and has various efficacies of promoting blood circulation, removing obstruction in channels, enriching blood, promoting qi circulation, benefiting blood, promoting the production of body fluid, calming nerves, benefiting intelligence and the like, and has obvious effect.

Description

Compound essence and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to compound essence and a preparation method thereof.
Background
The Chinese medicinal essential oil is a high-concentration concentrated extract of plants, and is used for extracting pure plant extract essence of Chinese medicinal herbs from the world, such as flowers, grass leaves, roots, stems, seeds and the like. The pure natural Chinese herbal medicine plant essential oil has high components, quick drug effect, strong permeability, and the active components have the effect of multiple times of the aromatic essential oil, and the extracted and refined Chinese herbal medicine plant essential oil has thousands of Chinese herbal medicines, so that the breadth of China is broad, the natural condition is superior, and the variety is extremely rich; the essential oil of the traditional Chinese medicine formula based on the classical ancient prescription compatibility has strong pertinence and obvious effect; the focus is on the efficacy of the drug property, which can directly enter the meridian product, directly enter the meridian and nourish the viscera through the skin, and the effective ingredients can be absorbed by small molecules.
Many kinds of essential oil products exist in the prior art, such as artemisia leaf essential oil, ligusticum wallichii essential oil, sandalwood essential oil, ginger essential oil, mint essential oil, eucommia ulmoides essential oil and the like. Patent CN201810705477.8, patent CN201210170671.3, patent CN201510120332.8 and patent CN201910327551.1 all also describe essential oil products with different functions. These kinds of essential oils have good therapeutic effects, and have the advantages of rapid absorption and convenient use. Although the prior art has a relatively comprehensive function of essential oil, the essential oil has a single function. For example, the essential oil of chuanxiong rhizome only has good improvement effect on the conditioning of constitutions such as overstrain; the ginger essential oil can only be used for hair care, and has better effects of brightening and moistening. And if consumers want essential oils with different functions, they must buy essential oil products with different functions. This not only consumes a lot of money, but also is very cumbersome to use, requiring the simultaneous use of different kinds of products. However, the prior art does not report how to provide a compound essential oil with multiple functions or multiple curative effects.
Therefore, how to provide a compound essence with multiple efficacies and a preparation method thereof is a problem which needs to be solved urgently by the technical personnel in the field.
Disclosure of Invention
The invention aims to provide a compound essence and a preparation method thereof, and aims to solve the problem that an essential oil product in the prior art is single in curative effect. The compound essence can be used for treating various diseases such as rheumatism, insomnia and the like, and has various effects of promoting blood circulation, removing obstruction in channels, enriching blood, promoting qi circulation, benefiting blood, promoting the production of body fluid, calming nerves, benefiting intelligence and the like.
In order to achieve the above object, the present invention provides the following technical solutions:
the compound essence is prepared from the following raw materials in parts by mass: 100-200 parts of base oil and 10-20 parts of traditional Chinese medicine essential oil.
Preferably, the base oil is one of olive oil, aloe oil and apricot kernel oil.
Preferably, the traditional Chinese medicine essential oil is prepared from the following raw materials in parts by mass: 5-10 parts of safflower essential oil, 6-12 parts of frankincense essential oil, 18-24 parts of dens draconis essential oil, 12-16 parts of amber essential oil, 8-12 parts of ginseng essential oil, 8-12 parts of angelica essential oil, 18-20 parts of wolfberry essential oil, 12-16 parts of spina date seed essential oil, 8-12 parts of nux vomica essential oil and 4-6 parts of medicinal cyathula root essential oil.
Preferably, the traditional Chinese medicine essential oil is prepared from the following raw materials in parts by mass: 8 parts of safflower essential oil, 9 parts of frankincense essential oil, 21 parts of dens draconis essential oil, 14 parts of amber essential oil, 10 parts of ginseng essential oil, 10 parts of angelica essential oil, 19 parts of medlar essential oil, 14 parts of spina date seed essential oil, 10 parts of nux vomica essential oil and 5 parts of medicinal cyathula root essential oil.
The invention also provides a preparation method of the compound essence, which comprises the following steps:
(1) pre-cooling Carthami flos, Olibanum, dens Draconis, Succinum, Ginseng radix, radix Angelicae sinensis, fructus Lycii, semen Ziziphi Spinosae, semen Strychni, and radix Cyathulae;
(2) freeze-drying the traditional Chinese medicine raw material obtained in the step (1);
(3) crushing the traditional Chinese medicine raw materials obtained in the step (2) and respectively carrying out supercritical extraction;
(4) respectively collecting the essential oils obtained in the step (3), and mixing the essential oils into the traditional Chinese medicine essential oil according to a proportion;
(5) mixing the base oil and the Chinese medicinal essential oil in proportion.
Preferably, the precooling in the step (1) is carried out for 4-6 h at-8 to-12 ℃.
Preferably, the freeze-drying temperature in the step (2) is-50 to-70 ℃, the pressure is 10 to 20Pa, and the time is 12 to 14 hours.
Preferably, the powder in the step (3) is crushed to 100-150 meshes.
Preferably, the supercritical extraction parameters in the step (3) are set to be extraction pressure of 8-18 MPa, extraction temperature of 35-55 ℃, carbon dioxide fluid flow of 20-30L/h, and extraction time of 2-3 h.
Preferably, the separation parameters are set to be that the pressure in the separator I is 8-12 Mpa, and the temperature is 25-35 ℃; the pressure in the separator II is 6-8 Mpa, and the temperature is 20-30 ℃.
The invention takes dens draconis, amber, spina date seed and medlar as monarch drugs, wherein the amber: has effects in relieving convulsion, tranquilizing mind, removing blood stasis, and stopping bleeding, and can be used for treating traumatic injury. The spina date seed has the effects of tonifying heart and spleen, calming heart and soothing nerves, can relieve physical and mental pressure and effectively promote sleep. The dens draconis not only has the effects of tranquilizing and allaying excitement, clearing heat and relieving restlessness, but also has the effect of removing dysphoria, and has good effect of adjusting mood for dizziness, dysphoria and irritability. The dens Draconis can also be used for treating restlessness, dreaminess during sleep, epilepsy and the like, and has good tranquilizing effect on central nerve. Wolfberry fruit, fructus Lycii, which is a yin-tonifying medicine classified under deficiency-tonifying medicines, has the effects of nourishing liver and kidney, replenishing vital essence and improving eyesight.
The invention takes ginseng, angelica and nux vomica as ministerial drugs. The ginseng can greatly tonify primordial qi, benefit blood and promote the production of body fluid, calm the mind and promote intelligence, promote heart, brain and lung, the angelica can strengthen the heart and promote blood circulation, and the nux vomica clears away the lung-heat and relieves sore throat and stops bleeding, belonging to the blood-activating and trauma-treating drugs classified under the drugs for activating blood and dissolving stasis. The three medicines can supplement original qi for patients, thereby improving the treatment effect of the main medicines.
The invention takes safflower and frankincense as adjuvant drugs. Safflower promotes blood circulation, clears the channels, removes blood stasis and relieves pain. Olibanum has effects of regulating qi, promoting blood circulation, relieving pain, eliminating swelling, and promoting granulation. Belongs to the blood-activating pain-relieving herbs classified under the blood-activating stasis-resolving herbs. The safflower and the frankincense can be added to promote blood circulation to remove meridian obstruction, enrich the blood and promote qi circulation, warm meridians and relieve pain, and accelerate the recovery time and recovery effect of patients.
The invention uses medicinal cyathula root as a guiding drug. Cyathula root, radix Cyathulae enters liver and kidney meridians. Dispel stasis, dredge meridians, dredge joints, induce diuresis and treat stranguria. It can be used for treating amenorrhea, abdominal mass, retention of exocytosis, arthralgia, flaccidity of feet, spasm of tendons, hematuria, stranguria with blood, traumatic injury, and radix Cyathulae can be added for nourishing liver and kidney, and strengthening tendons and bones.
Compared with the prior art, the invention has the following beneficial effects:
the compound essence disclosed by the invention not only has the effect of treating blood stasis inflammation, but also can be used for treating insomnia symptoms, and has a remarkable effect. Moreover, the invention also has the functions of tonifying spleen and lung, promoting the production of body fluid and soothing the nerves. Has the effects of replenishing vital essence and improving eyesight, and has good treatment effects on diseases such as cold womb, dysmenorrhea, irregular menstruation, cervical vertebra pain, arthralgia and the like, for example, various diseases such as rheumatic arthritis, general pain caused by postpartum wind exposure of women and the like. Can effectively eliminate clinical symptoms, and has reliable curative effect, good long-term curative effect and low recurrence rate. Except for pregnant women, the medicine should be used with cautions, and has no toxic and side effects.
Detailed Description
The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
The invention provides a compound essence which is prepared from the following raw materials in parts by mass: 100-200 parts of base oil and 10-20 parts of traditional Chinese medicine essential oil; preferably 120-180 parts of base oil and 12-18 parts of traditional Chinese medicine essential oil; further preferably 130-160 parts of base oil and 14-16 parts of traditional Chinese medicine essential oil; more preferably 150 parts of base oil and 15 parts of Chinese medicinal essential oil.
In the invention, the base oil is one of olive oil, aloe oil and apricot kernel oil; preferably olive oil.
In the invention, the traditional Chinese medicine essential oil is prepared from the following raw materials in parts by mass: 5-10 parts of safflower essential oil, 6-12 parts of frankincense essential oil, 18-24 parts of dens draconis essential oil, 12-16 parts of amber essential oil, 8-12 parts of ginseng essential oil, 8-12 parts of angelica essential oil, 18-20 parts of wolfberry essential oil, 12-16 parts of spina date seed essential oil, 8-12 parts of nux vomica essential oil and 4-6 parts of medicinal cyathula root essential oil;
preferably: 6-9 parts of safflower essential oil, 7-11 parts of frankincense essential oil, 19-23 parts of dens draconis essential oil, 13-15 parts of amber essential oil, 9-11 parts of ginseng essential oil, 9-11 parts of angelica essential oil, 18-19 parts of medlar essential oil, 13-15 parts of spina date seed essential oil, 9-11 parts of nux vomica essential oil and 4-5 parts of radix cyathulae essential oil;
more preferably: 8 parts of safflower essential oil, 9 parts of frankincense essential oil, 21 parts of dens draconis essential oil, 14 parts of amber essential oil, 10 parts of ginseng essential oil, 10 parts of angelica essential oil, 19 parts of medlar essential oil, 14 parts of spina date seed essential oil, 10 parts of nux vomica essential oil and 5 parts of medicinal cyathula root essential oil.
The invention also provides a preparation method of the compound essence, which comprises the following steps:
(1) pre-cooling Carthami flos, Olibanum, dens Draconis, Succinum, Ginseng radix, radix Angelicae sinensis, fructus Lycii, semen Ziziphi Spinosae, semen Strychni, and radix Cyathulae;
(2) freeze-drying the traditional Chinese medicine raw material obtained in the step (1);
(3) crushing the traditional Chinese medicine raw materials obtained in the step (2) and respectively carrying out supercritical extraction;
(4) respectively collecting the essential oils obtained in the step (3), and mixing the essential oils into the traditional Chinese medicine essential oil according to a proportion;
(5) mixing the base oil and the Chinese medicinal essential oil in proportion.
In the invention, the traditional Chinese medicine raw materials of safflower, frankincense, dens draconis, amber, ginseng, angelica, medlar, spina date seed, nux vomica and medicinal cyathula root are precooled for 4-6 h at-8-12 ℃ in the step (1); preferably precooling for 4-5 h at-9-11 ℃; further preferably at-10 ℃ and precooled for 5 h.
In the invention, the traditional Chinese medicine raw material obtained in the step (1) is subjected to freeze drying at the temperature of-50 to-70 ℃, under the pressure of 10 to 20Pa and for 12 to 14 hours in the step (2);
preferably, freeze drying is carried out at-55 to-65 ℃, the pressure is 12 to 18Pa and the time is 12 to 13 hours;
further preferably, the freeze-drying is carried out at-60 ℃ under a pressure of 15Pa for 13 hours.
In the invention, the traditional Chinese medicine raw materials obtained in the step (2) are crushed to 100-150 meshes in the step (3) and are subjected to supercritical extraction respectively; preferably 120 to 140 meshes, more preferably 125 to 135 meshes, and even more preferably 130 meshes.
In the invention, in the step (3), the supercritical extraction pressure is 8-18 MPa, the extraction temperature is 35-55 ℃, the flow rate of the carbon dioxide fluid is 20-30L/h, and the extraction time is 2-3 h;
preferably: the extraction pressure is 10-16 MPa, the extraction temperature is 38-52 ℃, the flow rate of carbon dioxide fluid is 22-28L/h, and the extraction time is 2-2.5 h;
further preferably, the extraction pressure is 13MPa, the extraction temperature is 45 ℃, the flow rate of the carbon dioxide fluid is 25L/h, and the extraction time is 2.5 h;
in the invention, the separation parameters in the step (3) are set to be 8-12 Mpa in the separator I and 25-35 ℃ in temperature; the pressure in the separator II is 6-8 Mpa, and the temperature is 20-30 ℃;
preferably, the pressure in the separator I is 9-11 Mpa, and the temperature is 27-33 ℃; the pressure in the separator II is 6-7 Mpa, and the temperature is 22-28 ℃;
further preferably, the pressure in the separator I is 10Mpa, and the temperature is 30 ℃; the pressure in separator II was 7MPa and the temperature was 25 ℃.
Example 1
The invention provides a preparation method of compound essence, which comprises the following steps:
(1) pre-cooling Carthami flos, Olibanum, dens Draconis, Succinum, Ginseng radix, radix Angelicae sinensis, fructus Lycii, semen Ziziphi Spinosae, semen Strychni, and radix Cyathulae at-8 deg.C for 4 hr;
(2) freeze-drying the traditional Chinese medicine raw material obtained in the step (1) at-50 ℃, under the pressure of 10Pa and for 12 hours;
(3) crushing the traditional Chinese medicine raw materials obtained in the step (2) to 100 meshes, and respectively performing supercritical extraction; the extraction pressure is 8MPa, the extraction temperature is 35 ℃, the flow rate of the carbon dioxide fluid is 20L/h, and the extraction time is 2 h; the separation parameters are set to 8Mpa in the separator I and 25 ℃ at the temperature; the pressure in the separator II is 6Mpa, and the temperature is 20 ℃;
(4) respectively collecting the essential oil obtained in the step (3), and mixing 5 parts of safflower essential oil, 6 parts of frankincense essential oil, 18 parts of dens draconis essential oil, 12 parts of amber essential oil, 8 parts of ginseng essential oil, 8 parts of angelica essential oil, 18 parts of medlar essential oil, 12 parts of spina date seed essential oil, 8 parts of nux vomica essential oil and 4 parts of medicinal cyathula root essential oil into traditional Chinese medicine essential oil;
(5) mixing the base oil and the Chinese medicinal essential oil according to the proportion of 100 parts of olive oil and 10 parts of Chinese medicinal essential oil.
Example 2
The invention provides a preparation method of compound essence, which comprises the following steps:
(1) pre-cooling Carthami flos, Olibanum, dens Draconis, Succinum, Ginseng radix, radix Angelicae sinensis, fructus Lycii, semen Ziziphi Spinosae, semen Strychni, and radix Cyathulae at-12 deg.C for 6 hr;
(2) freeze-drying the traditional Chinese medicine raw material obtained in the step (1) at-70 ℃, under the pressure of 20Pa and for 14 h;
(3) crushing the traditional Chinese medicine raw materials obtained in the step (2) to 150 meshes, and respectively performing supercritical extraction; the extraction pressure is 18MPa, the extraction temperature is 55 ℃, the flow of the carbon dioxide fluid is 30L/h, and the extraction time is 3 h; the separation parameters are set to 12Mpa in the separator I and 35 ℃; the pressure in the separator II is 8Mpa, and the temperature is 30 ℃;
(4) respectively collecting the essential oil obtained in the step (3), and mixing 10 parts of safflower essential oil, 12 parts of frankincense essential oil, 24 parts of dens draconis essential oil, 16 parts of amber essential oil, 12 parts of ginseng essential oil, 12 parts of angelica essential oil, 20 parts of medlar essential oil, 16 parts of spina date seed essential oil, 12 parts of nux vomica essential oil and 6 parts of radix cyathulae essential oil into traditional Chinese medicine essential oil;
(5) mixing the base oil and the Chinese medicinal essential oil according to the proportion of 200 parts of aloe oil and 20 parts of Chinese medicinal essential oil.
Example 3
The invention provides a preparation method of compound essence, which comprises the following steps:
(1) pre-cooling Carthami flos, Olibanum, dens Draconis, Succinum, Ginseng radix, radix Angelicae sinensis, fructus Lycii, semen Ziziphi Spinosae, semen Strychni, and radix Cyathulae at-10 deg.C for 5 hr;
(2) freeze-drying the traditional Chinese medicine raw material obtained in the step (1) at-60 ℃, under the pressure of 15Pa and for 13 h;
(3) crushing the traditional Chinese medicine raw materials obtained in the step (2) to 125 meshes, and respectively performing supercritical extraction; the extraction pressure is 13MPa, the extraction temperature is 45 ℃, the flow of the carbon dioxide fluid is 25L/h, and the extraction time is 2.5 h; setting the separation parameters as 10Mpa of pressure and 30 ℃ in the separator I; the pressure in the separator II is 7Mpa, and the temperature is 25 ℃;
(4) respectively collecting the essential oil obtained in the step (3), and mixing 8 parts of safflower essential oil, 9 parts of frankincense essential oil, 21 parts of dens draconis essential oil, 14 parts of amber essential oil, 10 parts of ginseng essential oil, 10 parts of angelica essential oil, 19 parts of medlar essential oil, 14 parts of spina date seed essential oil, 10 parts of nux vomica essential oil and 5 parts of medicinal cyathula root essential oil into traditional Chinese medicine essential oil;
(5) mixing the base oil and the Chinese medicinal essential oil according to the proportion of 150 parts of the apricot kernel oil and 15 parts of the Chinese medicinal essential oil.
Example 4
The effect of the compound essence is verified by a comparative experiment. 50 male patients and 50 female experimental patients with traumatic blood stasis and inflammation caused by various reasons are selected, 25 male patients and 25 female patients are randomly selected, and the compound essence obtained in the example 3 is applied to the 25 female patients. The rest 25 male patients, 25 female patients were smeared with common essential oil with blood stasis and inflammation treatment function on the market as a control group. The period of the experiment is 14 days, the change of the disease condition of the patient is observed and recorded on the 7 th day and the 14 th day of the experiment, and the result is shown in the table 1:
TABLE 1
Figure BDA0002995216160000071
As can be seen from Table 1, the cure rate of the invention in 14 days can reach 92%, the total effective rate can reach 100%, which is obviously higher than that of the control group. The compound essence has excellent effect of treating blood stasis inflammation.
Example 5
The effect of the compound essence is proved by comparative experiments. 75 male and 75 female test patients with insomnia (difficulty in falling asleep and difficulty in falling asleep after awakening) were selected. The experimental group randomly selected 25 male patients, and 25 female patients applied the compound essence obtained in example 3. 25 male patients and 25 female patients were randomly selected and smeared with the common essential oil with insomnia treatment function on the market as a control group. The remaining 25 male patients, 25 female patients were set as placebo group and applied with apricot kernel oil. Subjects were asked to sleep on days 7 and 14 of the experiment and the results are shown in table 2:
TABLE 2
Figure BDA0002995216160000081
As can be seen from the data in Table 2, the compound essence disclosed by the invention has excellent effect of treating insomnia, and the treatment effect of the compound essence is obviously superior to that of the essential oil products purchased on the market. On the next day of the experiment, the number of people falling asleep in half an hour was significantly greater in the test group than in the control group and the placebo group (wherein the number of people falling asleep in 1 hour included the number of people falling asleep in half an hour). And the number of people with midway wakefulness and people with more wakefulness in the morning in the test group is obviously more than that in the other two groups. The test data effect of the test group on the 14 th day of the test is also obviously superior to that of the placebo group and the control group, which shows that the compound essence has excellent effect of treating insomnia.
Example 6
Typical case 1
Jinzhi, male, 48 years old, suffered from hypertension for 5 years, had taken the hypotensive drug propranolol all the time, later, we visited the doctor, and the patient took propranolol and used the compound essence of the present invention. Applied to corresponding acupuncture points twice a day for 14 days as a treatment course. After 2 treatment courses, the blood viscosity of the patient is reduced, and the whole blood viscosity of the patient is reduced from 12.245 +/-1.874 before treatment to 9.917 +/-0.874 after treatment. After 10 treatment courses of the compound essence, the blood pressure is reduced to a normal value.
Typical case 2
Zhangiao, female, age 30, had difficulty sleeping every night and was easy to wake up. Can wake up 4 and 5 times at night, and is difficult to fall asleep after waking up, and the total sleep time at night is not more than 6 hours every day. The user still feels sleepy and sleeps when waking up every morning, and further the user cannot concentrate on working in the daytime. Various medications and treatments have been tried, but none of them is useful. Through introduction of friends, the doctor visits with the compound essence. The traditional Chinese medicine composition is applied to temple once every day before sleep, the sleep time is obviously reduced after one treatment course, and the sleep quality is obviously improved. After two treatment courses, people can sleep normally at night and are full of energy after waking in the morning, so that good sleep habits are formed.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims (10)

1. The compound essence is characterized by being prepared from the following raw materials in parts by mass: 100-200 parts of base oil and 10-20 parts of traditional Chinese medicine essential oil.
2. The compound essence of claim 1, wherein the base oil is one of olive oil, aloe oil, and apricot kernel oil.
3. The compound essence of claim 1, wherein the traditional Chinese medicine essential oil is prepared from the following raw materials in parts by mass: 5-10 parts of safflower essential oil, 6-12 parts of frankincense essential oil, 18-24 parts of dens draconis essential oil, 12-16 parts of amber essential oil, 8-12 parts of ginseng essential oil, 8-12 parts of angelica essential oil, 18-20 parts of wolfberry essential oil, 12-16 parts of spina date seed essential oil, 8-12 parts of nux vomica essential oil and 4-6 parts of medicinal cyathula root essential oil.
4. The compound essence of claim 3, wherein the traditional Chinese medicine essential oil is prepared from the following raw materials in parts by mass: 8 parts of safflower essential oil, 9 parts of frankincense essential oil, 21 parts of dens draconis essential oil, 14 parts of amber essential oil, 10 parts of ginseng essential oil, 10 parts of angelica essential oil, 19 parts of medlar essential oil, 14 parts of spina date seed essential oil, 10 parts of nux vomica essential oil and 5 parts of medicinal cyathula root essential oil.
5. The preparation method of the compound essence as claimed in any one of claims 1 to 4, comprising the following steps:
(1) pre-cooling Carthami flos, Olibanum, dens Draconis, Succinum, Ginseng radix, radix Angelicae sinensis, fructus Lycii, semen Ziziphi Spinosae, semen Strychni, and radix Cyathulae;
(2) freeze-drying the traditional Chinese medicine raw material obtained in the step (1);
(3) crushing the traditional Chinese medicine raw materials obtained in the step (2), and respectively carrying out supercritical extraction;
(4) respectively collecting the essential oils obtained in the step (3), and mixing the essential oils into the traditional Chinese medicine essential oil according to a proportion;
(5) mixing the base oil and the Chinese medicinal essential oil in proportion.
6. The preparation method of the compound essence according to claim 5, wherein the pre-cooling in the step (1) is carried out at-8 to-12 ℃ for 4 to 6 hours.
7. The preparation method of the compound essence according to claim 5 or 6, wherein the freeze-drying temperature in the step (2) is-50 to-70 ℃, the pressure is 10 to 20Pa, and the time is 12 to 14 hours.
8. The preparation method of the compound essence according to claim 5, wherein the step (3) is carried out by grinding to 100-150 meshes.
9. The preparation method of the compound essence according to claim 5, wherein the supercritical extraction parameters in the step (3) are set to extraction pressure of 8-18 MPa, extraction temperature of 35-55 ℃, carbon dioxide fluid flow of 20-30L/h, and extraction time of 2-3 h.
10. The preparation method of the compound essence according to claim 9, wherein the separation parameters are set to 8-12 Mpa pressure and 25-35 ℃ temperature in a separator I; the pressure in the separator II is 6-8 Mpa, and the temperature is 20-30 ℃.
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107233412A (en) * 2017-05-27 2017-10-10 江西中医药大学 It is a kind of to promote compound essential oil composition of sleep and its production and use
CN108686009A (en) * 2018-08-10 2018-10-23 江西中医药大学 Prevent and/or treat essential oil composition, preparation method, application and the preparation of rhinitis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107233412A (en) * 2017-05-27 2017-10-10 江西中医药大学 It is a kind of to promote compound essential oil composition of sleep and its production and use
CN108686009A (en) * 2018-08-10 2018-10-23 江西中医药大学 Prevent and/or treat essential oil composition, preparation method, application and the preparation of rhinitis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
张凤翔: "《现代实用美容学》", 31 July 2004, 中国科学技术出版社 *
彭成: "《中药药理学》", 31 August 2018, 中国医药科技出版社 *
董振飞: "《现代中药药理与方剂学》", 31 July 2018, 吉林科学技术出版社 *

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Application publication date: 20210625