CN113017995A - Adult diaper with uric acid prompting function - Google Patents
Adult diaper with uric acid prompting function Download PDFInfo
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- CN113017995A CN113017995A CN202110233442.0A CN202110233442A CN113017995A CN 113017995 A CN113017995 A CN 113017995A CN 202110233442 A CN202110233442 A CN 202110233442A CN 113017995 A CN113017995 A CN 113017995A
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- uric acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/45—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the shape
- A61F13/49—Absorbent articles specially adapted to be worn around the waist, e.g. diapers
- A61F13/496—Absorbent articles specially adapted to be worn around the waist, e.g. diapers in the form of pants or briefs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/42—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators with wetness indicator or alarm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/42—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators with wetness indicator or alarm
- A61F2013/422—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators with wetness indicator or alarm the alarm being a colour change
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/42—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators with wetness indicator or alarm
- A61F2013/427—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators with wetness indicator or alarm pH indicator
Abstract
The invention relates to the field of adult diapers. The adult diaper with the uric acid prompting function is characterized in that hydrogel with a porous structure is arranged on a surface layer or a core body of the diaper body contacting urine, the hydrogel comprises ethylene glycol and a color developing agent with a ligand coated on the surface, and the molecular formula of the color developing agent material is as follows: BaF2@CuCl2. The adult diaper with the uric acid prompting function is particularly suitable for users with high uric acid.
Description
Technical Field
The invention relates to the field of adult diapers, in particular to an adult diaper with a uric acid prompting function.
Background
The adult paper diaper has high utilization rate in bed-ridden nursing, light incontinence nursing and rehabilitation nursing, and structurally comprises a leakage-proof bottom film, an absorption core body and a surface layer, wherein the absorption core body is positioned between the leakage-proof bottom film and the surface layer. The existing adult paper diaper does not have the function of uric acid detection.
The main components of human urine include water, inorganic salts, organic substances and the like, wherein the inorganic substances include uric acid components. The quality of uric acid newly generated in a normal human body is equivalent to that of excreted uric acid, the uric acid is in a dynamic balance state, if excessive uric acid is generated in the human body and cannot be excreted in time or the excretion mechanism of uric acid is degraded, the uric acid in the human body is excessively retained, when the concentration of uric acid is high, the body fluid of the human body is changed into acid, the normal function of human body cells is influenced, and gout is caused in severe cases. The method for measuring uric acid mainly comprises a phosphotungstic acid reduction method, a uricase-peroxidase coupling method, a uric acid sensor detection method, a voltammetry method and the like [1-4], and the methods all need to be matched with specific instruments for use and are difficult to realize real-time visual judgment.
The molecular formula of uric acid is C through literature research5H4N4O3The molecular structure of the color developing agent contains a plurality of-NH bonds, the color developing agent is a color change which is directly shown through the reaction with substances, and the common color developing agent can not directly react with uric acid, so that the novel color developing agent which can react with uric acid is researched and developed, the accuracy of uric acid detection can be improved, the detection method can be simplified, and the color developing agent has a good application prospect in the multifunctional development field of disposable nursing pads.
Reference to the literature
[1] L. B. Rubia, R. Gomez, Journal of Pharmaceutical Sciences, 1977, 66, 1656-1657.
[2] N. Ferronato, M. L. N. Pinedo, V. Torretta, Sustainability, 2020, 12, 5055.
[3] Y. Budyk, A. Fullana, Journal of Environmental Chmical Engineering, 2019, 7, 103341.
[4] S. C. Khoo, X. Y. Phang, C. M. Ng, K. L. Lim, S. S. Lam, N. L. Ma, Process Safety and Ennironmental Protection, 2019, 123, 116-129.
[5] A. B. Patil, C. B. Zheng, L. Y. Ma, R. H. Wu, S. K. Mengane, Y. F. Zhang, X. T. Liu, Z. H. Meng, W. L. Zhang, Z. J. Xu, C. F. Chen, J. N. Huang, X. Y. Liu, Nanotechnology, 2021, 32, 065502.
[6] C. Y. Huang, H. C. Hsiao, Sensors, 2020, 20.
[7] C. Borghi, C. Bentivenga, E. R. Cosentino, International Journal of Cardiology, 2020, 320, 23-24.
[8] H. Y. Zhang, S. Liu, Journal of Alloys and Compounds, 2020, 842, 155873。
Disclosure of Invention
In order to enrich the variety of adult diapers, the application aims to provide the adult diaper with the uric acid prompting function, urine is adsorbed by the hydrogel with the porous structure, after the color developing agent with the ligand coated on the surface in the hydrogel meets the urine, hydroxyl (-OH) on the surface of the compound and-NH in urine molecules form a bond through electrostatic attraction, and then copper chloride in the compound and uric acid in the urine react to form an organic-inorganic complex which is green and can be well applied to quantitative concentration detection of the uric acid.
In order to achieve the above object, the present application adopts the following technical solutions:
the adult diaper with the uric acid prompting function is characterized in that hydrogel with a porous structure is arranged on a surface layer or a core body of the diaper body contacting urine, the hydrogel comprises ethylene glycol and a color developing agent with a ligand coated on the surface, and the molecular formula of the color developing agent material is as follows: BaF2@CuCl2。
Preferably, the hydrogel absorbs 5-50 ml of urine, the hydrogel does not develop color when the concentration of uric acid in the urine is lower than a threshold value, the hydrogel displays green color when the concentration of uric acid in the urine is higher than the threshold value, and the concentration of uric acid is in direct proportion to the brightness degree of the color developing agent. BaF2@CuCl2The surface of the color developing agent is coated with salicylic acid and EDTA, and the molar ratio of the salicylic acid to the EDTA is 1: (0.3-0.5). The threshold value is that the uric acid concentration in urine is 420 mu mol/L. The hydrogel is prepared from deionized water, polyoxyethylene glycol diester, ethanol, and 2-methyl-2- (4-morpholinyl) -1- [4- (methylthio) phenyl]1-acetone and a color developing agent with the surface coated with ligand. The color developing agent coated with the ligand on the surface accounts for 10-20% of the whole hydrogel according to mass percentage.
Preferably, the method for preparing the hydrogel comprises the following steps: (1) dissolving 30 mg of prepared salicylic acid and Ethylene Diamine Tetraacetic Acid (EDTA) ligand modified barium fluoride-copper chloride compound color developing agent into 30-40 ml of deionized water, and then adding 20-25 ml of acrylic acid polyethylene glycol diester; (2) carrying out ultrasonic treatment in an ultrasonic instrument with the power more than 1KW for 3-6 hours, then adding 2-methyl-2- (4-morpholinyl) -1- [4- (methylthio) phenyl ] -1-acetone, and stirring for 60-80 minutes at room temperature; (3) irradiating the solution with a laser with power of 2-3W and wavelength of 907 nm for 30-50 min, and adding 50 microliter of ethanol every 3 min during irradiation to obtain the hydrogel with porous structure.
Preferably, the method of preparing the developer material comprises the steps of:
1) dissolving (1-2) millimole of barium acetate and (2-4) millimole of ammonium fluoride in (4-8) milliliter of deionized water, and stirring at room temperature for 30-60 minutes, wherein the molar ratio of the barium acetate to the ammonium fluoride is 1: 2;
2) adding (20-30) ml of oleic acid and (10-20) ml of octadecene into the mixture in the step 1), stirring the mixture at room temperature for (30-60) minutes, transferring the mixture into a hydrothermal kettle, and performing hydrothermal reaction at 160 DEGoC-200oC, preserving heat for 12-24 hours;
3) centrifugally washing the product obtained in the step 2) for 3-5 times by using a mixed solution of cyclohexane and ethanol (the volume ratio is 1: 3), and then dispersing the obtained nanocrystal in (4-8) ml of cyclohexane;
4) adding 1-2 ml of dilute hydrochloric acid (1.6 mol/L) into the solution obtained in the step 3), carrying out ultrasonic treatment in an ultrasonic cleaning instrument with the power of more than 1 kilowatt for 30-60 minutes, then carrying out centrifugal washing (1-2) times by using a mixed solution of ethanol and deionized water (the volume ratio is 1: 3), and dispersing the obtained nanocrystals in (2-4) ml of deionized water;
5) stirring (30-60) mmol of copper acetate (0.5-1), 5-20 ml of glacial acetic acid and 40-60 ml of deionized water at room temperature for 30-60 min;
6) adding the nanocrystalline solution obtained in the step (4) into the solution obtained in the step 5), and stirring at room temperature for 30-60 minutes;
7) adding 0.3-1 ml of dilute hydrochloric acid into the solution obtained in the step 6), and stirring at room temperature for 10-20 minutes;
8) adding salicylic acid and EDTA (with the molar ratio of 1: (0.3-0.5) the total molar amount of which is the same as that of copper acetate), stirring at room temperature for 2-5 minutes, and then placing in a temperature range of 30-40oAnd C, standing in an oven for 24-48 hours, and finally storing the obtained color developing agent in a black bottle.
This patent is applied to adult diaper with porous structure's aquogel, after aquogel adsorbed the urine, the aquogel dissolves, surface cladding has barium fluoride-copper chloride complex colour developing agent contact uric acid of ligand in the aquogel, the volume through detecting uric acid is that uric acid concentration decides whether barium fluoride-copper chloride complex colour developing agent shows promptly, the aquogel does not take place the colour when uric acid concentration is less than the threshold value in the urine promptly, the aquogel shows green when uric acid concentration is higher than the threshold value in the urine, and the bright degree of uric acid concentration and colour developing agent colour is directly proportional, its bright degree deepens gradually along with the increase of uric acid concentration. To sum up, the adult diaper with uric acid prompt function of this patent is particularly suitable for uric acid user to use to a bit high.
Drawings
FIG. 1 shows the result of inductively coupled plasma atomic emission spectroscopy analysis of a barium fluoride-copper chloride complex developer.
FIG. 2 is a transmission electron microscope image of a barium fluoride-copper chloride complex color developer.
FIG. 3 is a graph of green light intensity of barium fluoride-copper chloride complex color developing agent coated by salicylic acid and EDTA double ligand in relation to uric acid concentration.
FIG. 4 is a graph of green light intensity of color developing agent without surface ligand modification and uric acid concentration.
FIG. 5 is a graph of green light intensity of a salicylic acid ligand-modified color-developing agent alone as a function of uric acid concentration.
FIG. 6 is a graph of green light intensity of EDTA ligand modified color developing agent alone as a function of uric acid concentration.
FIG. 7 shows uric acid concentration detection performance of hydrogel.
Detailed Description
Experimental part
The main reagents are as follows: barium acetate (99.0%), ammonium fluoride (99.0%), copper acetate (99.9%), glacial acetic acid (100%), oleic acid, octadecene (90%), salicylic acid, EDTA and uric acid (99%) were purchased from Sigma-Aldrich, cyclohexane, ethanol, dilute hydrochloric acid and deionized water were purchased from national pharmaceutical group chemicals, ltd, and test urine was taken from adults.
Characterization apparatus and method
Inductively coupled plasma atomic emission spectroscopy (ZX-Z5000-WLD5000, powder sample, frequency 50/60 Hz), transmission electron microscopy (TEM, FEI Tecnai G2F 20), and spectroscopy (FLUROUB-B, HORIBA JOBIN YVON).
Preparation of atomic emission spectrometry test sample: freezing and drying the color developing agent to obtain a powdery sample;
preparation of transmission electron microscope samples: dissolving a little developer in 4 ml of ethanol solution, and dropping 3-6 drops of liquid on the ultrathin carbon film after ultrasonic treatment for 5 minutes.
The detection method of uric acid comprises the following steps: removing color developing agents with certain volume, dividing the color developing agents into a plurality of groups, adding different molar amounts of uric acid into each group, representing the change of the fluorescence intensity by a fluorescence spectrometer, and fitting a standard curve.
The concentration of uric acid refers to the content of uric acid per unit volume of aqueous solution.
BaF2@CuCl2Preparation of
1 mmol of barium acetate and 2 mmol of ammonium fluoride are dissolved in 4 ml of deionized water and stirred at room temperature for 30 minutes; then 20 ml oleic acid and 10 ml octadecene were added, stirred at room temperature for 60 minutes, then transferred to a hydrothermal kettle and heated at 180 deg.CoC, preserving the heat for 12 hours; mixing BaF2Centrifugally washing with a mixed solution of cyclohexane and ethanol (volume ratio of 1: 3) for 3 times, and then washing BaF2The nanocrystals were dispersed in 4 ml of cyclohexane; adding 1 ml of dilute hydrochloric acid into the solution, carrying out ultrasonic treatment in an ultrasonic cleaning instrument with the power of 1 kilowatt for 30 minutes, then carrying out centrifugal washing for 1 time by using a mixed solution (the volume ratio is 1: 3) of ethanol and deionized water, and carrying out BaF treatment2Dispersing the nanocrystals in 2 ml of deionized water; stirring 1 mmol of copper acetate, 10 ml of glacial acetic acid and 40 ml of deionized water at room temperature for 30 minutes to obtain a solution A; adding BaF into the solution A2Stirring the nanocrystalline solution at room temperature for 60 minutes; then adding 0.5 ml of dilute hydrochloric acid into the solution, and stirring for 10 minutes at room temperature; salicylic acid and EDTA (1: 0.4 molar ratio) were added, the total molar amount of which was 1 mmol, and the mixture was stirred at room temperature for 5 minutes and then placed at 30oC, standing in an oven for 24 hours, and finally storing the obtained color developing agent in blackAnd (4) color bottles.
Preparation of hydrogels
Dissolving 30 mg of prepared salicylic acid and Ethylene Diamine Tetraacetic Acid (EDTA) ligand modified barium fluoride-copper chloride compound color developing agent into 30-40 ml of deionized water, and then adding 20-25 ml of acrylic acid polyethylene glycol diester; carrying out ultrasonic treatment in an ultrasonic instrument with the power more than 1KW for 3-6 hours, then adding 2-methyl-2- (4-morpholinyl) -1- [4- (methylthio) phenyl ] -1-acetone, and stirring for 60-80 minutes at room temperature; irradiating the solution with a laser with power of 2-3W and wavelength of 907 nm for 30-50 min, and adding 50 microliter of ethanol every 3 min during irradiation to obtain the hydrogel with porous structure.
The color developing agent uniformly distributed in the hydrogel needs to react with a certain amount of uric acid to realize color development, when the concentration of the uric acid is lower than the critical value, the color developing agent cannot develop color, otherwise, when the concentration of the uric acid is higher than the critical value, the color developing agent can develop color, and the critical value is defined as the threshold value of the concentration of the uric acid.
The amount of the adult single urine is generally 200-.
The hydrogel obtained by the preparation method is suitable for absorbing 10 ml of urine, and can be realized by adjusting the mass of the color-developing agent in the hydrogel when the amount of the absorbed urine needs to be adjusted, for example, when the mass of the color-developing agent is 35 mg, the color-developing agent is suitable for absorbing 20 ml of urine.
The hydrogel is a gel with a three-dimensional network structure formed by the induction of a photoinitiator under the irradiation of an external light source, and the color developing agent is uniformly distributed in the three-dimensional network structure of the hydrogel.
And (3) converting the brightness of the color developing agent into a color rendering index through the numerical value of the fluorescence intensity, wherein the color rendering index card corresponds to the color rendering index of the hydrogel. When the concentration of uric acid in urine is in a normal range, namely less than 420 mu mol/L, the color developing agent does not develop color, the color developing index is less than 1, and when the concentration of uric acid in urine is out of the normal range, the color developing agent begins to develop color, and the color developing index is more than 1. The larger the color rendering index is, the larger the deviation of the uric acid concentration in the detected urine from the normal value is.
The method comprises the steps of representing the color development intensity of hydrogel under the conditions of different concentrations of uric acid, dividing the color development intensity value by a special value due to the fact that the value of the color development intensity is usually large, converting the color development intensity value into a color development index with a small value, manufacturing a color development index card by combining the significance of the concentration of the uric acid of a human body in the aspect of the biomedical science, and comparing the hydrogel after actual use with the color development index card so as to deduce the concentration of the uric acid in urine. The disposable nursing pad with uric acid prompt facility of this patent belongs to the nursing articles for use, because user's individual difference, the complete unity can not be accomplished to color rendering index and threshold value, and its precision that detects also is not 100% accuracy, and this product is particularly useful for mild uric acid user on the high side to use, through detecting daily color rendering index, through making the comparison with the color rendering index of oneself before promptly, judges recent uric acid concentration situation.
When the barium fluoride-copper chloride compound color developing agent material with the ligand coated on the surface is used for directly detecting uric acid, the amount of the color developing agent is large in order to improve the detection sensitivity, and a small amount of uric acid can cause color development. In order to realize the function of detecting the threshold value, the use amount of the color developing agent is reduced in the preparation process of the hydrogel, when the mass percentage of the color developing agent is lower than 10%, the color developing sensitivity of the hydrogel is too low, and the detection of low-concentration uric acid cannot be realized, and when the mass percentage of the color developing agent is higher than 20%, the color developing sensitivity of the hydrogel is too high, and the threshold function of detecting the concentration of uric acid cannot be realized.
As shown in FIG. 1, the result of atomic emission spectroscopy analysis of inductively coupled plasma shows that the barium fluoride-copper chloride product modified by salicylic acid and EDTA ligand contains Ba, Cu, F and Cl elements, and the molar percentages are 17.12%, 16.24%, 33.85% and 32.79%, which are substantially in accordance with the molar percentages added in the starting materials, indicating that the resulting product is CaF2@Li0.1K0.9BiI4. The analysis result of the transmission electron microscope shows that the product has irregular appearance. The preparation process of the product comprises the following steps: firstly, barium ions in raw materials are combined with fluorine ions to form oleic acid coated BaF2Removing surface ligand by hydrochloric acid treatment, and then treating with BaF2Copper chloride is formed on the surface, and salicylic acid and EDTA ligand are coated by further surface modification.
The salicylic acid and EDTA ligand modified barium fluoride-copper chloride product is light white, and the color of the product is changed into green after a small amount of uric acid is added into the color developing agent. The mechanism is explained as follows: carboxyl in the ligand and-NH bond in uric acid promote copper chloride and uric acid to form a complex through electrostatic attraction, the complex is finally green, the color of the solution is gradually deepened along with the continuous increase of the concentration of uric acid, and the change amplitude of the complex can be characterized through fluorescence spectrum. As shown in FIG. 3, the intensity of green light is gradually enhanced with the continuous increase of the concentration of uric acid, and a clear positive correlation is shown, so that the standard curve can be used for quantitative detection of uric acid.
The ligand coated on the surface of the color-developing agent is specially designed, and the barium fluoride-copper chloride color-developing agent without ligand modification is prepared in order to verify the importance of modifying barium fluoride-copper chloride by adopting salicylic acid and EDTA ligand. As shown in fig. 4, no color change occurred with the addition of uric acid to this developer, and even when the amount of uric acid was increased to 100. mu. mol/l, no color change occurred in the developer, indicating that the surface ligand helps to promote the binding of the developer and uric acid by surface action to form a complex.
To verify the effect of each ligand separately, barium fluoride-copper chloride complexes modified with salicylic acid or EDTA single ligands were prepared separately. As shown in fig. 5, when uric acid is added to the salicylic acid ligand modified barium fluoride-copper chloride color developing agent alone, the intensity of green light is increased by a very small amount, and no color change occurs. As shown in FIG. 6, for the EDTA single ligand modified barium fluoride-copper chloride color developing agent, the luminous intensity is hardly concentrated with uric acidChange in degree, when an excess of Na is added to the solution+After ionization, the developer turned to a blue-green color, indicating that the color change of the developer was due to too much Na being adsorbed by the EDTA ligand+Caused by ions.
The applicant of the patent researches a barium fluoride-copper chloride compound modified by polyacrylic acid, salicylic acid and EDTA (ethylene diamine tetraacetic acid) three ligands, and is mainly applied to urinary development.
FIG. 7 is the data of the hydrogel in the example for detecting uric acid, and it can be seen that the fluorescence intensity is not substantially changed when the uric acid concentration is lower than 420 micromole/liter, and the fluorescence intensity is obviously changed when the uric acid concentration exceeds 420 micromole/liter.
The barium fluoride nanocrystalline is prepared by a solvothermal method, a surface ligand is removed by hydrochloric acid treatment, then the barium fluoride-copper chloride compound color developing agent is prepared by taking the nanocrystalline as a core and adopting a room-temperature stirring method, and then the barium fluoride-copper chloride compound color developing agent coated by salicylic acid and an EDTA ligand is prepared by surface modification. When the color developing agent is added with uric acid, the solution is dark green, the brightness degree of the solution is in direct proportion to the concentration of the uric acid, and the quantitative detection of the uric acid can be well applied by fitting a relation curve of green light intensity and the concentration of the uric acid. The urine of normal person is added into the barium fluoride-copper chloride color developing agent, the green color can be obviously seen, the brightness degree of the urine is gradually deepened along with the increase of the concentration of uric acid, and after the concentration of the uric acid reaches a certain degree, the EDTA adsorbs excessive Na+Ions, resulting in the color developer turning to a blue-green color.
Claims (9)
1. The adult diaper with the uric acid prompting function is characterized in that hydrogel with a porous structure is arranged on a surface layer or a core body of the diaper body contacting urine, the hydrogel comprises ethylene glycol and a color developing agent with a ligand coated on the surface,the molecular formula of the developer material is as follows: BaF2@CuCl2。
2. The adult diaper with uric acid prompting function according to claim 1, wherein the hydrogel absorbs 5-50 ml of urine, the hydrogel does not develop color when the concentration of uric acid in the urine is lower than a threshold value, the hydrogel develops green when the concentration of uric acid in the urine is higher than the threshold value, and the concentration of uric acid is proportional to the brightness of the color developing agent.
3. The adult diaper with uric acid prompting function of claim 2, wherein BaF is2@CuCl2The surface of the color developing agent is coated with salicylic acid and EDTA.
4. The adult diaper with uric acid prompting function according to claim 2 or 3, wherein the threshold is that the uric acid concentration in urine is 420 μmol/L.
5. The adult diaper with uric acid prompting function according to claim 2, wherein the hydrogel is prepared from deionized water, acrylic acid polyethylene glycol diester, ethanol, 2-methyl-2- (4-morpholinyl) -1- [4- (methylthio) phenyl ] -1-acetone and a color developing agent with a ligand-coated surface.
6. The adult diaper with uric acid prompting function according to claim 2, wherein the color developing agent coated with the ligand on the surface accounts for 10-20% of the hydrogel in mass percent.
7. The adult diaper with uric acid prompting function according to claim 2, characterized in that the molar ratio of salicylic acid and EDTA is 1: (0.3-0.5).
8. The adult diaper with uric acid prompting function according to claim 7, wherein the preparation method of the hydrogel comprises the following steps: (1) dissolving 30 mg of prepared salicylic acid and Ethylene Diamine Tetraacetic Acid (EDTA) ligand modified barium fluoride-copper chloride compound color developing agent into 30-40 ml of deionized water, and then adding 20-25 ml of acrylic acid polyethylene glycol diester; (2) carrying out ultrasonic treatment in an ultrasonic instrument with the power more than 1KW for 3-6 hours, then adding 2-methyl-2- (4-morpholinyl) -1- [4- (methylthio) phenyl ] -1-acetone, and stirring for 60-80 minutes at room temperature; (3) irradiating the solution with a laser with power of 2-3W and wavelength of 907 nm for 30-50 min, and adding 50 microliter of ethanol every 3 min during irradiation to obtain the hydrogel with porous structure.
9. The adult diaper with uric acid prompting function according to claim 1, wherein the preparation method of the color developer material comprises the following steps:
1) dissolving (1-2) millimole of barium acetate and (2-4) millimole of ammonium fluoride in (4-8) milliliter of deionized water, and stirring at room temperature for 30-60 minutes, wherein the molar ratio of the barium acetate to the ammonium fluoride is 1: 2;
2) adding (20-30) ml of oleic acid and (10-20) ml of octadecene into the mixture in the step 1), stirring the mixture at room temperature for (30-60) minutes, transferring the mixture into a hydrothermal kettle, and performing hydrothermal reaction at 160 DEGoC-200oC, preserving heat for 12-24 hours;
3) centrifugally washing the product obtained in the step 2) for 3-5 times by using a mixed solution of cyclohexane and ethanol (the volume ratio is 1: 3), and then dispersing the obtained nanocrystal in (4-8) ml of cyclohexane;
4) adding 1-2 ml of dilute hydrochloric acid (1.6 mol/L) into the solution obtained in the step 3), carrying out ultrasonic treatment in an ultrasonic cleaning instrument with the power of more than 1 kilowatt for 30-60 minutes, then carrying out centrifugal washing (1-2) times by using a mixed solution of ethanol and deionized water (the volume ratio is 1: 3), and dispersing the obtained nanocrystals in (2-4) ml of deionized water;
5) stirring (30-60) mmol of copper acetate (0.5-1), 5-20 ml of glacial acetic acid and 40-60 ml of deionized water at room temperature for 30-60 min;
6) adding the nanocrystalline solution obtained in the step (4) into the solution obtained in the step 5), and stirring at room temperature for 30-60 minutes;
7) adding 0.3-1 ml of dilute hydrochloric acid into the solution obtained in the step 6), and stirring at room temperature for 10-20 minutes;
8) adding salicylic acid and EDTA (with the molar ratio of 1: (0.3-0.5) the total molar amount of which is the same as that of copper acetate), stirring at room temperature for 2-5 minutes, and then placing in a temperature range of 30-40oAnd C, standing in an oven for 24-48 hours, and finally storing the obtained color developing agent in a black bottle.
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| CN202110233442.0A CN113017995B (en) | 2021-03-03 | 2021-03-03 | Adult diaper with uric acid prompting function |
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