CN112998168A - Hyaluronic acid composite polypeptide beverage and preparation method thereof - Google Patents
Hyaluronic acid composite polypeptide beverage and preparation method thereof Download PDFInfo
- Publication number
- CN112998168A CN112998168A CN202110440914.XA CN202110440914A CN112998168A CN 112998168 A CN112998168 A CN 112998168A CN 202110440914 A CN202110440914 A CN 202110440914A CN 112998168 A CN112998168 A CN 112998168A
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- CN
- China
- Prior art keywords
- powder
- chitosan
- beverage
- solution
- hyaluronic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 25
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Images
Classifications
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
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Abstract
The invention relates to the field of preparation of health-care drinks and discloses a hyaluronic acid composite polypeptide drink and a preparation method thereof, wherein the hyaluronic acid composite polypeptide drink comprises the following components in percentage by weight: 0.01-0.05% of fish collagen peptide, 5-10% of litchi concentrated juice, 5-15% of high fructose corn syrup, 0.1-0.2% of plant extract, 0.1-0.3% of fruit juice powder, 0.01-0.05% of olive powder, 0.01-0.05% of inulin and the balance of liquid solvent, wherein the liquid solvent is a mixed solution of sodium hyaluronate and chitosan, and the liquid solvent contains 0.2-0.5% of sodium hyaluronate and 0.1-1.0% of chitosan.
Description
Technical Field
The invention relates to the field of preparation of health-care drinks, in particular to a hyaluronic acid composite polypeptide drink and a preparation method thereof.
Background
With the age, the functions of the body begin to decline, and the most intuitive phenomenon of skin aging occurs. Scientific studies have shown that the causes of these skin aging are mainly the following: (1) because of self metabolism generation and excessive ultraviolet rays or even ionizing radiation exposure, a large amount of free radicals are accumulated in the organism, and the self clearing speed is difficult to match; (2) unsmooth circulation in the body and insufficient qi and blood caused by disordered work and rest, overlarge pressure, low immunity and the like; (3) with aging, a large amount of skin structural substances such as collagen in the body are lost.
With the increased awareness of health care, many people have begun to choose to take nutritional supplements to condition and improve this condition. However, the existing nutritional supplements have single efficacy and unobvious effect, and in addition, most of the existing nutritional supplements select bioactive products such as proteins, polypeptides and the like, so that the stability is poor, and the nutritional supplements have great limitation in the transportation, storage and selling processes, thereby limiting the further development of the nutritional supplements.
Disclosure of Invention
Therefore, the hyaluronic acid compound polypeptide beverage and the preparation method thereof are needed to be provided, and the problem that the skin improvement effect of the existing nutritional beverage is not obvious is solved.
In order to achieve the purpose, the invention provides a hyaluronic acid composite polypeptide beverage which comprises the following components in percentage by weight: 0.01-0.05% of fish collagen peptide, 5-10% of litchi concentrated juice, 5-15% of high fructose corn syrup, 0.1-0.2% of plant extract, 0.1-0.3% of fruit juice powder, 0.01-0.05% of olive powder, 0.01-0.05% of inulin and the balance of liquid solvent;
the liquid solvent is a mixed solution of sodium hyaluronate and chitosan, and contains 0.2-0.5% of sodium hyaluronate and 0.1-1.0% of chitosan.
Furthermore, the molecular weight of the chitosan is 5-10KDa, and the molecular weight of the sodium hyaluronate is 5-10 KDa.
Further, the ratio of the sodium hyaluronate to the chitosan is controlled to be 1: 1-2.
Further, the plant extract comprises grape seed extract and field thistle powder, and the ratio of the grape seed extract to the field thistle powder is 1: 0.1.
Further, the extraction steps of the grape seed extract are as follows:
(1) weighing grape seeds, crushing by a crusher, and sieving by a sieve of 20-40 meshes to obtain grape seed powder;
(2) adding 5-10 times of ethanol into grape seed powder, and performing ultrasonic extraction to obtain grape seed extractive solution, wherein the ultrasonic frequency is controlled at 20-40kHz and the ultrasonic time is 1-3 h;
(3) and carrying out vacuum drying on the grape seed extracting solution to obtain the grape seed extract.
Further, the particle size of the herba cephalanoploris powder is 80-100 meshes.
Further, the fruit juice powder comprises wild cherry concentrated powder, blackcurrant concentrated powder and blood orange concentrated powder, and the ratio of the wild cherry concentrated powder, the blackcurrant concentrated powder and the blood orange concentrated powder is 1:1: 1.
Further comprises 0.01 to 0.03 percent of L-cysteine, 0.01 to 0.03 percent of vitamin C, 0.001 to 0.005 percent of vitamin E, 0.055 to 0.10 percent of xanthan gum, 0.05 to 0.06 percent of citric acid and 0.1 to 0.3 percent of potassium sorbate according to weight percentage.
The preparation method of any one of the hyaluronic acid composite polypeptide drinks comprises the following steps:
(1) adding chitosan into water to prepare a chitosan solution;
(2) weighing sodium hyaluronate, adding the sodium hyaluronate into a chitosan solution under stirring to obtain a liquid solvent;
(3) weighing fish collagen peptide, adding the fish collagen peptide into a liquid solvent, and uniformly stirring to obtain a mixed solution A;
(4) weighing plant extract, adding 2-5 times of water to form plant extract solution, weighing fruit juice powder, and adding 2-5 times of water to form fruit juice solution;
(5) adding the litchi concentrated juice, the plant extract solution and the fruit juice solution into the mixed solution A, uniformly stirring, continuously adding the high fructose corn syrup, the olive powder, the inulin and the rest water, and heating and boiling to obtain a beverage liquid;
(6) the finished product beverage is obtained by filtering, filling and sterilizing the beverage liquid.
Further, in the step (5), the heating temperature is 90-100 ℃, and the heating time is 3-8 min.
The effects of the components of the invention are as follows:
sodium hyaluronate: effectively replenishing water and locking water, improving fine lines and wrinkles, strongly resisting oxidation, enhancing SOD activity of cells, lubricating bone joints and increasing flexibility of bone tissues and ligaments.
Chitosan oligosaccharide: supplementing essential vital elements, reducing blood lipid, blood sugar and blood pressure, regulating immunity, regulating pH, regulating endocrine, inhibiting cancer cell growth, inhibiting cancer cell metastasis, inhibiting cancer toxin, enhancing liver function, scavenging free radicals, proliferating beneficial bacteria in intestinal tract, eliminating excessive harmful cholesterol and chloride ions, eliminating heavy metal harmful ions, and eliminating vivotoxin.
Wild cherry: rich in high-concentration polyphenol, has strong antioxidation, and has good effects in preventing and improving thrombosis, atherosclerosis and coronary heart disease in pathological state.
Grape seed extract: a polyphenol extracted and separated from grape seeds mainly comprises polyphenols such as procyanidine, catechin, epicatechin, gallic acid, epicatechin gallate and the like. The grape seed extract is a pure natural substance and is one of the most efficient antioxidants from plant sources found so far, and tests show that the antioxidant effect of the grape seed extract is 30-50 times that of vitamin C and vitamin E.
Herba Cirsii powder: the herba Cephalanoploris powder is a Chinese medicinal powder, and is prepared by grinding dried herba Cephalanoploris as raw material. The herba Cephalanoploris powder retains most of the nutritional and medicinal components of herba Cephalanoploris.
The technical scheme has the following beneficial effects:
1. the composition provided by the invention mainly comprises fish collagen peptide, sodium hyaluronate, plant extract and chitosan oligosaccharide, wherein the sodium hyaluronate has the effects of strongly supplementing water, strongly resisting oxidation and enhancing the SOD activity of cells, the fish collagen peptide can promote the synthesis of skin collagen, and the components in the formula are combined according to a certain proportion, so that each substance can generate a remarkable coordination and synergism effect, the skin water content can be improved, the skin elasticity and glossiness can be increased, the skin color can be improved, the effect display period is short, and the skin aging can be effectively delayed.
2. According to the invention, a mixed solution of a sodium hyaluronate solution and a chitosan solution is used as a liquid solvent, and simultaneously, as the sodium hyaluronate and the chitosan have more hydroxyl groups, after the sodium hyaluronate and the chitosan are prepared into a solution with water, the hydroxyl groups among the sodium hyaluronate, the chitosan and the water form hydrogen bonds, so that the solution has certain stability, and simultaneously, subsequently added fish collagen peptide polypeptide molecules have stronger intermolecular forces with the hydroxyl groups and the hydrogen bonds, and the sodium hyaluronate has higher biocompatibility, has the function of stabilizing the polypeptide molecules, and prevents the denaturation of proteins or the polypeptide molecules, so that the drink disclosed by the invention can play roles of supplementing individual nutrition, improving skin moisture and delaying skin aging.
Drawings
Fig. 1 shows the result of measuring the moisture content of skin according to the embodiment.
FIG. 2 is a graph showing the effect of the beverage of the present invention on the malondialdehyde content according to the embodiment.
FIG. 3 is a graph showing the effect of the beverage of the present invention on the content of superoxide dismutase.
FIG. 4 shows the effect of the beverage according to the present invention on the content of glutathione peroxidase.
Detailed Description
To explain technical contents, structural features, and objects and effects of the technical solutions in detail, the following detailed description is given with reference to the accompanying drawings in conjunction with the embodiments.
Example 1
The hyaluronic acid composite polypeptide drink comprises the following components in percentage by weight: 0.04% fish collagen peptide, 10% litchi concentrated juice, 10% fructose syrup, 0.04% grape seed extract, 0.004% common cephalanoplos herb powder, 0.04% wild cherry concentrated powder, 0.04% blackcurrant concentrated powder, 0.04% blood orange concentrated powder, 0.04% olive powder, 0.04% inulin, 0.01% to 0.03% L-cysteine, 0.01% to 0.03% vitamin C, 0.001% to 0.005% vitamin E, 0.055% to 0.10% xanthan gum, 0.05% to 0.06% citric acid and 0.1% to 0.3% potassium sorbate, and the balance of liquid solvent, wherein the liquid solvent is a mixed solution of sodium hyaluronate and chitosan, and the liquid solvent contains 0.32% sodium hyaluronate solution and 0.64% chitosan solution. The molecular weight of the chitosan is 5KDa, and the molecular weight of the sodium hyaluronate is 5 KDa.
The extraction steps of the grape seed extract are as follows:
(1) weighing grape seeds, crushing by a crusher, and sieving by a sieve of 20-40 meshes to obtain grape seed powder;
(2) adding 5-10 times of ethanol into grape seed powder, and performing ultrasonic extraction to obtain grape seed extractive solution, wherein the ultrasonic frequency is controlled at 20-40kHz and the ultrasonic time is 1-3 h;
(3) and carrying out vacuum drying on the grape seed extracting solution to obtain the grape seed extract.
The herba Cephalanoploris powder is prepared by grinding dried traditional Chinese medicine herba Cephalanoploris, and sieving with 80-100 mesh sieve.
The preparation method of the hyaluronic acid composite polypeptide drink comprises the following steps:
(1) adding chitosan into water to prepare a chitosan solution;
(2) weighing sodium hyaluronate, adding the sodium hyaluronate into a chitosan solution under stirring to obtain a liquid solvent;
(3) weighing fish collagen peptide, adding the fish collagen peptide into a liquid solvent, and uniformly stirring to obtain a mixed solution A;
(4) weighing plant extract, adding 5 times of water to form plant extract solution, weighing fruit juice powder, and adding 5 times of water to form fruit juice solution;
(5) adding concentrated litchi juice, plant extract solution, and fruit juice solution into the mixed solution A, stirring, adding fructose-glucose syrup, olive powder, inulin and the rest water, heating and boiling to obtain beverage liquid at 90-100 deg.C for 3-8 min.
(6) The finished product beverage is obtained by filtering, filling and sterilizing the beverage liquid.
In the embodiment, the chitosan and the sodium hyaluronate are firstly mixed to form the liquid solvent, the molecular weights of the chitosan and the sodium hyaluronate are in the same level, so that the chitosan and the sodium hyaluronate are more easily dissolved, meanwhile, the chitosan and the sodium hyaluronate can form hydrogen bonds with the fish collagen peptide, the stability of the structure of the fish collagen peptide is favorably ensured, and the fish collagen peptide still has higher biological nutritive value after being heated, boiled or placed for a long time.
In the present invention, the solubility of chitosan and hyaluronic acid cannot be too high, otherwise the chitosan and hyaluronic acid solution is liable to form colloid or form floc insoluble in water.
Example 2
Different from the embodiment 1, the hyaluronic acid composite polypeptide beverage comprises the following components in parts by weight: 0.01% of fish collagen peptide, 5% of litchi concentrated juice, 5% of high fructose corn syrup, 0.1% of plant extract, 0.1% of fruit juice powder, 0.01% of olive powder, 0.01% of inulin and the balance of liquid solvent; the molecular weight of the chitosan is 5KDa, the molecular weight of the sodium hyaluronate is 5KDa, and the liquid solvent contains 0.2% of sodium hyaluronate and 0.1% of chitosan.
Example 3
Different from the embodiment 1, the hyaluronic acid composite polypeptide beverage comprises the following components in percentage by weight: 0.05% of fish collagen peptide, 10% of litchi concentrated juice, 15% of high fructose corn syrup, 0.2% of plant extract, 0.3% of fruit juice powder, 0.05% of olive powder, 0.05% of inulin and the balance of liquid solvent; the liquid solvent contained 0.5% sodium hyaluronate and 1.0% chitosan.
Study on skin function improvement of the finished beverages of examples 1-3
1. Material
Male SPF-grade mice of Kunming species, 40, were randomly divided into 4 groups of 10 mice each, of which 3 groups were experimental groups and 1 group was blank control group.
2. Experiment of
The breeding temperature is 21-25 deg.C, humidity is 50-70%, and day and night intermittent illumination is 12h/12 h. During the experiment the animals had free access to water. The 3 experimental groups correspond to the finished product drinks of the examples 1-3, the blank control group corresponds to normal saline, and the mice are gavaged with 0.5ml of the normal saline every time, 1 time every day and 7 days continuously.
3. Result detection
(1) After the mice are sacrificed, the skin of the same exposed area of the mice is taken, cut into pieces and evenly placed in a weighing bottle, and the water content of the skin of the mice is measured by adopting a drying method.
(2) Skin activity index determination: changes in superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity and Malondialdehyde (MDA) content were detected using ELISA.
4. Analysis of results
Superoxide dismutase is an antioxidant metalloenzyme existing in organisms, glutathione peroxidase is an important peroxide catabolic enzyme widely existing in organisms, Malondialdehyde (MDA) is a final decomposition product of membrane lipid peroxidation in the organisms, and the accumulation of MDA can cause certain damage to membranes and cells.
The detection results are shown in the attached figures 1-4, and the detection results show that the drink can greatly increase the moisture of the skin, simultaneously can improve the serum content level of the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in mice, and reduces the content level of Malondialdehyde (MDA), so that the drink has strong water replenishing effect and strong oxidation resistance and can effectively slow down the skin aging.
Example 4
A hyaluronic acid complex polypeptide beverage is different from the beverage prepared in the embodiment 1, and the preparation method comprises the following steps:
(1) adding chitosan into water to prepare a chitosan solution;
(2) weighing sodium hyaluronate, adding the sodium hyaluronate into a chitosan solution under stirring to obtain a liquid solvent;
(3) weighing fish collagen peptide, adding the fish collagen peptide into a liquid solvent, and uniformly stirring to obtain a mixed solution A;
(4) weighing plant extract, adding 2 times of water to form plant extract solution, weighing fruit juice powder, and adding 2 times of water to form fruit juice solution;
(5) adding concentrated litchi juice, plant extract solution, and fruit juice solution into the mixed solution A, stirring, adding fructose-glucose syrup, olive powder, inulin and the rest water, heating and boiling to obtain beverage liquid at 90-100 deg.C for 3-8 min.
Comparative example 1
A hyaluronic acid polypeptide complex beverage, which is different from the beverage prepared in example 1 in that a liquid solvent does not contain chitosan, and the liquid solvent is 0.32% sodium hyaluronate solution.
Comparative example 2
A composite polypeptide beverage, which differs from example 1 in that the liquid solvent does not contain sodium hyaluronate, and is prepared as a 0.64% chitosan solution.
Comparative example 3
A composite polypeptide beverage, which is different from the beverage prepared in the embodiment 1 in that the liquid solvent is purified water.
Stability experiments were conducted on the beverages prepared in example 1, comparative example 1 and comparative example 2.
1. Centrifugal sedimentation rate
1.1 taking 10ml of each sample and weighing M1;
1.2 centrifuging at 50000rpm for 10min, and recording the sediment amount M2 after centrifugation;
1.3 calculation of the centrifugal precipitation Rate
The centrifugation yield (SR) was (M2/M1) × 100%.
The results of the test calculations are shown in table 1.
TABLE 1 centrifuge sedimentation rates of the drinks prepared in example 1, comparative example 1 and comparative example 2.
2. Observation of stability
The drinks prepared in example 1, comparative example 1 and comparative example 2 were stored at 4 ℃ and 25 ℃ respectively, and the precipitation was observed for 1 day, 3 days, 14 days, 21 days and 28 days respectively, and the centrifugal precipitation rate was measured, and the results are shown in table 2.
TABLE 2 stability observations of example 1, comparative example 1 and comparative example 2
Note: stipulating: micro-precipitation: SR is more than 0 and less than 0.50 percent; a small amount of precipitate: SR is more than or equal to 0.50% and less than 1.50%;
and (3) precipitation: SR is more than or equal to 1.50% and less than 3.50%, and a large amount of precipitates are: SR is more than or equal to 3.50%.
As can be seen from tables 1 and 2, the use of hyaluronic acid and chitosan can stabilize the whole solution system, and meanwhile, hyaluronic acid and chitosan have a synergistic effect in the solution system, so that the stability of the beverage can be enhanced.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or terminal that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or terminal. Without further limitation, an element defined by the phrases "comprising … …" or "comprising … …" does not exclude the presence of additional elements in a process, method, article, or terminal that comprises the element. Further, herein, "greater than," "less than," "more than," and the like are understood to exclude the present numbers; the terms "above", "below", "within" and the like are to be understood as including the number.
Although the embodiments have been described, once the basic inventive concept is obtained, other variations and modifications of these embodiments can be made by those skilled in the art, so that the above embodiments are only examples of the present invention, and not intended to limit the scope of the present invention, and all equivalent structures or equivalent processes using the contents of the present specification and drawings, or any other related technical fields, which are directly or indirectly applied thereto, are included in the scope of the present invention.
Claims (10)
1. The hyaluronic acid composite polypeptide drink is characterized by comprising the following components in percentage by weight: 0.01-0.05% of fish collagen peptide, 5-10% of litchi concentrated juice, 5-15% of high fructose corn syrup, 0.1-0.2% of plant extract, 0.1-0.3% of fruit juice powder, 0.01-0.05% of olive powder, 0.01-0.05% of inulin and the balance of liquid solvent;
the liquid solvent is a mixed solution of sodium hyaluronate and chitosan, and contains 0.2-0.5% of sodium hyaluronate and 0.1-1.0% of chitosan.
2. The beverage of claim 1, wherein the chitosan has a molecular weight of 5-10KDa, and the sodium hyaluronate has a molecular weight of 5-10 KDa.
3. The hyaluronic acid complex polypeptide beverage of claim 2, wherein the ratio of the amount of the sodium hyaluronate to the amount of the chitosan is controlled to be 1: 2.
4. The beverage of claim 1, wherein the plant extract comprises grape seed extract and herba Cirsii powder, and the ratio of grape seed extract to herba Cirsii powder is 1: 0.1.
5. The hyaluronic acid complex polypeptide beverage of claim 4, wherein the extraction step of the grape seed extract is as follows:
(1) weighing grape seeds, crushing by a crusher, and sieving by a sieve of 20-40 meshes to obtain grape seed powder;
(2) adding 5-10 times of ethanol into grape seed powder, and performing ultrasonic extraction to obtain grape seed extractive solution, wherein the ultrasonic frequency is controlled at 20-40kHz and the ultrasonic time is 1-3 h;
(3) and carrying out vacuum drying on the grape seed extracting solution to obtain the grape seed extract.
6. The hyaluronic acid complex polypeptide beverage of claim 4, wherein the particle size of the Cirsium setosum powder is 80-100 mesh.
7. The hyaluronic acid complex polypeptide beverage of claim 1, wherein the fruit juice powder comprises cerasus serrulata concentrate powder, blackcurrant concentrate powder and blood orange concentrate powder, and the proportion of the cerasus serrulata concentrate powder, the blackcurrant concentrate powder and the blood orange concentrate powder is 1:1: 1.
8. The hyaluronic acid complex polypeptide beverage of claim 1, further comprising, by weight, 0.01% -0.03% L-cysteine, 0.01% -0.03% vitamin C, 0.001% -0.005% vitamin E, 0.055-0.10% xanthan gum, 0.05% -0.06% citric acid, and 0.1% -0.3% potassium sorbate.
9. The preparation method of the hyaluronic acid composite polypeptide beverage as described in any one of claims 1-8, comprising the following steps:
(1) adding chitosan into water to prepare a chitosan solution;
(2) weighing sodium hyaluronate, adding the sodium hyaluronate into a chitosan solution under stirring to obtain a liquid solvent;
(3) weighing fish collagen peptide, adding the fish collagen peptide into a liquid solvent, and uniformly stirring to obtain a mixed solution A;
(4) weighing plant extract, adding 2-5 times of water to form plant extract solution, weighing fruit juice powder, and adding 2-5 times of water to form fruit juice solution;
(5) adding the litchi concentrated juice, the plant extract solution and the fruit juice solution into the mixed solution A, uniformly stirring, continuously adding the high fructose corn syrup, the olive powder, the inulin and the rest water, and heating and boiling to obtain a beverage liquid;
(6) the finished product beverage is obtained by filtering, filling and sterilizing the beverage liquid.
10. The method according to claim 9, wherein in the step (5), the heating temperature is 90 to 100 ℃ and the heating time is 3 to 8 min.
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| CN113287695A (en) * | 2021-06-30 | 2021-08-24 | 山东东阿东方阿胶股份有限公司 | Sodium hyaluronate collagen beverage and preparation method thereof |
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