CN112957280A - 一种干性牙齿美白增白贴膜 - Google Patents
一种干性牙齿美白增白贴膜 Download PDFInfo
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- CN112957280A CN112957280A CN202110151000.1A CN202110151000A CN112957280A CN 112957280 A CN112957280 A CN 112957280A CN 202110151000 A CN202110151000 A CN 202110151000A CN 112957280 A CN112957280 A CN 112957280A
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- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
本发明公开了一种干性牙齿美白增白贴膜,包括四层结构,第一层是载体薄膜层,第二层是干性疏水高分子层,第三层干性亲水高分子层,第四层是薄膜剥离背衬层,由以上四层顺次堆叠连接而成。本发明的干性美白牙贴方便使用及携带,对于牙齿的粘附力大能,其美白效果好,并且能够长时间黏附在牙齿上且能够长时间缓释美白成分的浓度实现持续给药,同时干性干性疏水高分子层遇水后粘度降低,使用几分钟后载体薄膜层可取下,减少长期使用过程带来的不适,同时能够防止干性亲水高分子层中的过氧化物对口腔皮肤接触带来的灼伤等。由于不含水,能够大幅度的提高牙贴活性组分的稳定性,从而提高牙贴的有效时间。
Description
技术领域
本发明属于人体牙齿护理技术领域,涉及一种使用于人体牙齿的干性牙齿美白增白贴膜。
背景技术
洁白漂亮的牙齿一直是人们追求的一种时尚。我国吸烟、喝茶、喝咖啡的人数以亿计, 由于长期作用, 牙齿表面都不同程度地粘有微黄色、黄色或黄褐色的色素斑, 严重地影响牙齿的美观。对牙齿增白美容的要求与日俱增,对牙齿增白美容的方式方法和效果要求越来越高,既要求在牙齿增白美容过程中不损害牙质,又要求省时方便,简单实用而效果显著。
在家庭牙齿美白过程中,牙贴美白则将美白剂涂布在贴片材料上,贴片材料覆盖需要美白的牙齿,达到牙齿美白的目的。牙贴美白相对较牙托美白价格低、操作简单,是目前最常用的家庭美白方法目前的牙齿增白贴膜,虽然具有用简单、方便和实用的优点和一定效果,但还存在着所述的某些、甚至是突出的主要缺点。
目前,美白牙贴主要以凝胶湿贴为主,即将美白剂、高分子凝胶剂、保湿剂、水等组分制成凝胶后,涂附在高分子薄膜表面制成美白牙贴,这种美白牙贴的水、保湿剂含量高呈湿润状态,导致其对于牙齿的粘附力不足导致不能再牙齿表面进行长时间的给药。
另一方面,湿贴贴在牙齿上以后其中含有的过氧化物等美白剂将在30分钟内迅速降低,无法达到控释缓释的目的,使得部分美白剂并无法达到美白效果,需提高美白剂浓度来达到较好的美白效果,但提高美白剂浓度后易造成牙齿敏感。
发明内容
为解决上述问题,本发明提供一种高稳定性牙齿增白贴膜,本发明的干性美白牙贴方便使用及携带,对于牙齿的粘附力大能,其美白效果好,并且能够长时间黏附在牙齿上且干性美白牙贴对过氧化物等美白剂的扩散速度较慢,只有贴在牙齿上以后,经过湿润的部分才具有较好的美白剂的扩散速度,这样就能够长时间缓释美白成分的浓度实现持续给药。同时干性疏水高分子层遇水后粘度降低使用10分钟后载体薄膜层可取下,减少长期使用过程带来的不适,同时能够防止干性亲水高分子层中的过氧化物对口腔皮肤接触带来的灼伤等。且由于不含水量低,能够大幅度的提高牙贴活性组分的稳定性,从而提高牙贴的有效时间;加入抑菌和抗过敏组分,对口腔的刺激性小,且能够起到抑制口腔细菌生长的作用。
为实现上述发明目的,本发明采用如下技术方案。
一种干性牙齿美白增白贴膜,其特征在于:包括四层结构,第一层是载体薄膜层,第二层是干性疏水高分子层,第三层干性亲水高分子层,第四层是薄膜剥离背衬层,由以上四层顺次堆叠连接而成。
所述的干性疏水高分子层在涂布在载体薄膜层的一个面上,为乙醇与高分子凝胶混合后经过溶剂脱除制成的疏水凝胶体系,其厚度0.02-0.1毫米,所述高分子凝胶包括高分子增稠剂和保湿剂;所述高分子增稠剂由丙烯酸脂共聚物、聚乙烯吡咯烷酮、丙烯酸酯/辛基丙烯酰胺共聚物、卡波姆树脂、聚乙烯醇树脂中的一种或多种组成,保湿剂由甘油、乙醇、丙二醇、山梨醇、水中的一种或多种混合而成;由于在口腔中遇水后干性疏水高分子层的粘度迅速降低,在使用5-10分钟后载体薄膜层可剥离,提高长时间使用的舒适度,同时能够防止干性亲水高分子层中的过氧化物对口腔皮肤接触带来的灼伤等问题。
所述的干性亲水高分子层涂布在干性疏水高分子层的一个面上,另一个面上贴有薄膜剥离背衬层;由美白剂、高分子增稠剂、保湿剂、稳定剂、抑菌剂、PH调节剂、增溶剂、抗过敏剂及香精醇等,经过脱水脱溶剂处理后得到,其厚度0.05-0.2毫米;其中,美白剂为过氧化脲、过氧化氢、次氯酸钠、过氯酸钠、高氯酸钠、碱性过硼酸盐、过碳酸盐、碳酸氢钠、邻苯二甲酰亚胺过氧己酸、过氧乙酸中的一种或多种;高分子增稠剂为卡波姆树脂、羟甲基纤维素钠、羟乙基纤维素、聚乙烯吡咯烷酮、聚乙烯醇树脂、黄原胶、天然树胶、丙烯酸脂共聚物中的一种或多种;保湿剂为甘油、乙醇、丙二醇、山梨醇、木糖醇、水中的一种或多种;稳定剂为N-羟乙基乙二胺三乙酸、乙二胺四乙酸二钠、多乙烯多胺多亚烷基膦酸盐(DTPMP-NaPA), 柠檬酸钠、金属螯合离子中的一种或多种;PH调节剂为磷酸、柠檬酸、三乙醇胺、氢氧化钠溶液中的一种或多种组成;增溶剂为聚氧乙烯醚氢化蓖麻油、Tween-20、聚乙二醇、聚丙二醇中的一种或两种组成;抑菌剂包括邻苯二甲酸及其盐、双氯苯双肌己烷、阿来西定、血根碱、苯扎氯按、度米芬、对苯二甲酞氯中的一种或多种;抗过敏剂由硝酸钾、羟基磷灰石、二氧化硅、碳酸氢钙、碳酸钙中的一种或多种组成。并且干性亲水高分子层由于没有水和溶剂的存在,美白组分在其中的扩散速度很慢,能够保证美白成分缓释给药从而能够延长作用时间。
进一步地,所述的薄膜剥离背衬层的制作材料为透明的料薄膜、箔或纸。
进一步地,所述的干性亲水高分子层中,按照重量百分比,组分含量为:美白剂1%-20%、高分子增稠剂1%-80%、保湿剂0-20%、稳定剂0.1%-1%、抑菌剂0.1-0.5%、PH调节剂0.2-3%、增溶剂1%-10%、抗过敏剂0.1-8%。
进一步地,在美白剂配方中含有过氧化物的情况下,为保证过氧化物的稳定性,所述的干性亲水高分子层中水和乙醇的总含量低于10%。
进一步地,当美白剂配方中含有过氧化物的情况下,所述干性亲水高分子层中加金属络合物稳定剂或聚乙烯吡咯烷酮形成共轭过氧键来提高过氧化物的稳定性。
进一步地,所述金属络合物稳定剂的质量含量为稳定剂的0.1%-1%,聚乙烯吡咯烷酮的质量含量为稳定剂的1%-10%;金属络合物为Na-EDTA或无钠EDTA。
进一步地,所述的干性疏水高分子层中,按质量份数计,高分子增稠剂1%-80%,保湿剂0-50%。
进一步地,所述的载体薄膜层由聚乙烯制成,厚度为0.05毫米。
进一步地,为了达到载体薄膜层更快剥离速度,所述的干性疏水高分子层中高分子增稠剂由丙烯酸脂共聚物、聚乙烯吡咯烷酮、丙烯酸酯/辛基丙烯酰胺共聚物组成。
本发明的有益效果是:
1.该牙贴方便使用及携带,对于牙齿的粘附力大能,其美白效果好,并且能够长时间黏附在牙齿上且干性美白牙贴对过氧化物等美白剂的扩散速度较慢,只有贴在牙齿上以后,经过湿润的部分才具有较好的美白剂的扩散速度,这样就能够长时间缓释美白成分的浓度实现持续给药。
2.干性疏水高分子层使用过程中遇水后粘度迅速降低,可以保证使用十分钟后载体薄膜层可剥离,提高长时间使用的舒适度,同时能够防止干性亲水高分子层中的过氧化物对口腔皮肤接触带来的灼伤等,其厚度0.02-0.1毫米。
3.由于不含水或含水量低,能够大幅度的提高牙贴活性组分的稳定性,从而提高牙贴的有效时间;加入抑菌和抗过敏组分,对口腔的刺激性小,且能够起到抑制口腔细菌生长的作用。
4.可根据使用的时限,美白的要求调节不同的干性亲水高分子层和干性疏水高分子层的厚度,来实现不同的美白效果。
附图说明
图1 是本发明的主视示意图;
在图中,1、载体薄膜层,2、干性疏水高分子层,3、干性亲水高分子层,4、薄膜剥离背衬层。
具体实施方式
下面结合实施例对本发明的干性牙齿美白增白贴膜进一步说明,但本发明的发明范围不限于以下实施例。
实施例1:如图1所示,一种干性牙齿美白增白贴膜,包括四层结构,第一层是载体薄膜层1,第二层是干性疏水高分子层2,第三层干性亲水高分子层3,第四层是薄膜剥离背衬层4,由以上四层顺次堆叠连接而成。
第一层载体薄膜层1的厚度为0.05毫米,原料为聚乙烯。
第二层干性疏水高分子层2,厚度为0.05毫米。结构成分的比例按重量百分比计,丙烯酸脂共聚物10%,丙烯酸酯/辛基丙烯酰胺共聚物10%,聚乙烯吡咯烷酮30%,保湿剂:甘油 10%,聚乙二醇18%, EDTA 二钠 1%,柠檬酸钠 2%,三乙醇胺2%,薄荷醇 2%,聚氧乙烯醚氢化蓖麻油5%。在口腔中遇水后,干性疏水高分子层2的粘度迅速降低,载体薄膜层剥离时间为5分钟左右。
第三层干性亲水高分子层3,厚度为0.05毫米。结构成分的比例按重量百分比计,活性组分:过氧化脲 20%;高分子羟甲基纤维素钠10%,卡波树脂 10%,聚乙烯吡咯烷酮30%,保湿剂:甘油10%,EDTA 二钠2%,柠檬酸钠2%,三乙醇胺2%,薄荷醇1%,聚氧乙烯醚氢化蓖麻油3%;水 5%,邻苯二甲酸1%,硝酸钾3%,羟基磷灰石1%。
干性牙齿美白增白贴膜的使用时间为1小时左右。
实施例2:
如图1所示,一种干性牙齿美白增白贴膜,包括四层结构,第一层是载体薄膜层1,第二层是干性疏水高分子层2,第三层干性亲水高分子层3,第四层是薄膜剥离背衬层4,由以上四层顺次堆叠连接而成。
第一层载体薄膜层1的厚度为0.05毫米,原料为聚乙烯。
第二层干性疏水高分子层2,脱除溶剂后,厚度为0.05毫米。结构成分的比例按重量百分比计,丙烯酸酯/辛基丙烯酰胺共聚物50%,聚乙烯吡咯烷酮10%,甘油10%,EDTA二钠1%,柠檬酸钠 1%,三乙醇胺3%,薄荷醇 2%,聚氧乙烯醚氢化蓖麻油3%。在口腔中遇水后,干性疏水高分子层2的粘度迅速降低,载体薄膜层1的剥离时间为7分钟左右。
第三层干性亲水高分子层3,脱除溶剂后,厚度为0.1毫米。结构成分的比例按重量百分比计,活性组分:过氧化氢5%;高分子羟甲基纤维素钠5%,卡波树脂5%,聚乙烯吡咯烷酮40%,保湿剂:甘油 10%,丙二醇20%, EDTA 二钠 1%,柠檬酸钠 1%,三乙醇胺1%,薄荷醇 2%,聚氧乙烯醚氢化蓖麻油3%;水 2%,邻苯二甲酸1%,硝酸钾4%。
干性牙齿美白增白贴膜的使用时间为2小时左右。
实施例3:
如图1所示,一种干性牙齿美白增白贴膜,包括四层结构,第一层是载体薄膜层1,第二层是干性疏水高分子层2,第三层干性亲水高分子层3,第四层是薄膜剥离背衬层4,由以上四层顺次堆叠连接而成。
第一层载体薄膜层1的厚度为0.05毫米,原料为聚乙烯。
第二层干性疏水高分子层2,经溶剂蒸发后,厚度为0.05毫米。结构成分的比例按重量百分比计,聚乙烯醇树脂30%,卡波树脂 10%,聚乙烯吡咯烷酮30%,保湿剂:丙二醇20%,EDTA二钠1%,柠檬酸钠 2%,三乙醇胺2%,薄荷醇2%,表面活性剂:聚氧乙烯醚氢化蓖麻油3%。在口腔中遇水后,干性疏水高分子层2的粘度迅速降低,载体薄膜层1的剥离时间为10分钟左右。
第三层干性亲水高分子层3,经溶剂蒸发后,厚度为0.05毫米。结构成分的比例按重量百分比计,活性组分:邻苯二甲酰亚胺过氧己酸20%;高分子羟甲基纤维素钠10%,卡波树脂10 %,聚乙烯吡咯烷酮23%,保湿剂:甘油 5%,聚乙二醇20%, EDTA 二钠 0.5%,柠檬酸钠 0.5%,三乙醇胺2%,薄荷醇 1%,聚氧乙烯醚氢化蓖麻油2 %;水 5%,邻苯二甲酸1%。
干性牙齿美白增白贴膜的使用时间为0.5小时左右。
实施例4:
如图1所示,一种干性牙齿美白增白贴膜,包括四层结构,第一层是载体薄膜层1,第二层是干性疏水高分子层2,第三层干性亲水高分子层3,第四层是薄膜剥离背衬层4,由以上四层顺次堆叠连接而成。
第一层载体薄膜层1的厚度为0.05毫米,原料为聚乙烯。
第二层干性疏水高分子层2,经溶剂蒸发后,厚度为0.1毫米。结构成分的比例按重量百分比计,丙烯酸酯/辛基丙烯酰胺共聚物10%,聚乙烯吡咯烷酮50%,聚丙二醇20%, EDTA二钠 2%,柠檬酸钠 3%,三乙醇胺2,薄荷醇 1%,聚氧乙烯醚氢化蓖麻油4%。在口腔中遇水后,干性疏水高分子层2的粘度迅速降低,载体薄膜层1可剥离时间为5分钟左右。
第三层干性亲水高分子层3,经溶剂蒸发后,厚度为0.2毫米。结构成分的比例按重量百分比计,活性组分:次氯酸钠5%;高分子羟甲基纤维素钠20%,卡波树脂 5%,聚乙烯吡咯烷酮30%,保湿剂:甘油 5%,丙二醇21 %, EDTA 二钠 0.5%,柠檬酸钠 0.5%,三乙醇胺0.5%,薄荷醇 1%,表面活性剂:聚氧乙烯醚氢化蓖麻油3%;水 5%,邻苯二甲酸0.5%,羟基磷灰石3%。
干性牙齿美白增白贴膜的使用时间为8小时左右。
实施例5:
实施例1:如图1所示,一种干性牙齿美白增白贴膜,包括四层结构,第一层是载体薄膜层1,第二层是干性疏水高分子层2,第三层干性亲水高分子层3,第四层是薄膜剥离背衬层4,由以上四层顺次堆叠连接而成。
第一层载体薄膜层1的厚度为0.05毫米,原料为聚乙烯。
第二层干性疏水高分子层2,厚度为0.05毫米。结构成分的比例按重量百分比计,聚乙烯醇20%,卡波树脂15%,聚乙烯吡咯烷酮45%,保湿剂:甘油 10%, EDTA 二钠 2%,柠檬酸钠 2%,三乙醇胺2%,薄荷醇 2%,聚氧乙烯醚氢化蓖麻油4%。在口腔中遇水后,干性疏水高分子层2的粘度迅速降低,载体薄膜层1可剥离时间为10分钟左右。
第三层干性亲水高分子层3,厚度为0.15毫米。结构成分的比例按重量百分比计,活性组分:过氧化脲10%;高分子羟甲基纤维素钠5%,卡波树脂 5%,聚乙烯吡咯烷酮50%,保湿剂:甘油 15%, EDTA 二钠 0.5%,柠檬酸钠 0.5%,三乙醇胺0.5%,薄荷醇 0.5%,表面活性剂:聚氧乙烯醚氢化蓖麻油3%;水 5%,邻苯二甲酸1%,硝酸钾4%。
干性牙齿美白增白贴膜的使用时间为4小时左右。
以上所述是本发明的优选实施例,应当指出,对于本技术领域的普通技术人员来说,在不脱离本发明原理的前提下,还可以做出若干改进和润饰,这些改进和润饰也视为本发明的保护范围。
Claims (9)
1.一种干性牙齿美白增白贴膜,其特征在于:包括四层结构,第一层是载体薄膜层,第二层是干性疏水高分子层,第三层干性亲水高分子层,第四层是薄膜剥离背衬层,由以上四层顺次堆叠连接而成;
所述的干性疏水高分子层涂布在载体薄膜层的一个面上,为乙醇与高分子凝胶混合后经过溶剂脱除制成的疏水凝胶体系,其厚度0.02-0.1毫米,所述高分子凝胶包括高分子增稠剂和保湿剂;所述高分子增稠剂由丙烯酸脂共聚物、聚乙烯吡咯烷酮、丙烯酸酯或辛基丙烯酰胺共聚物、卡波姆树脂、聚乙烯醇树脂中的一种或多种组成,保湿剂由甘油、乙醇、丙二醇、山梨醇、水中的一种或多种混合而成;
所述的干性亲水高分子层涂布在干性疏水高分子层的一个面上,另一个面上贴有薄膜剥离背衬层;由美白剂、高分子增稠剂、保湿剂、稳定剂、抑菌剂、PH调节剂、增溶剂、抗过敏剂及香精醇,经过脱水脱溶剂处理后得到,其厚度0.05-0.2毫米;其中,美白剂为过氧化脲、过氧化氢、次氯酸钠、过氯酸钠、高氯酸钠、碱性过硼酸盐、过碳酸盐、碳酸氢钠、邻苯二甲酰亚胺过氧己酸、过氧乙酸中的一种或多种;高分子增稠剂为卡波姆树脂、羟甲基纤维素钠、羟乙基纤维素、聚乙烯吡咯烷酮、聚乙烯醇树脂、黄原胶、天然树胶、丙烯酸脂共聚物中的一种或多种;保湿剂为甘油、乙醇、丙二醇、山梨醇、木糖醇、水中的一种或多种;稳定剂为N-羟乙基乙二胺三乙酸、乙二胺四乙酸二钠、多乙烯多胺多亚烷基膦酸盐、柠檬酸钠、金属螯合离子中的一种或多种;PH调节剂为磷酸、柠檬酸、三乙醇胺、氢氧化钠溶液中的一种或多种组成;增溶剂为聚氧乙烯醚氢化蓖麻油、Tween-20、聚乙二醇、聚丙二醇中的一种或两种组成;抑菌剂包括邻苯二甲酸及其盐、双氯苯双肌己烷、阿来西定、血根碱、苯扎氯按、度米芬、对苯二甲酞氯中的一种或多种;抗过敏剂由硝酸钾、羟基磷灰石、二氧化硅、碳酸氢钙、碳酸钙中的一种或多种组成。
2.根据权利要求1所述的干性牙齿美白增白贴膜,其特征在于:所述的薄膜剥离背衬层的制作材料为透明的料薄膜、箔或纸。
3.根据权利要求1所述的干性牙齿美白增白贴膜,其特征在于:所述的干性亲水高分子层中,按照重量百分比,组分含量为:美白剂1%-20%、高分子增稠剂1%-80%、保湿剂0-20%、稳定剂0.1%-1%、抑菌剂0.1-0.5%、PH调节剂0.2-3%、增溶剂1%-10%、抗过敏剂0.1-8%。
4.根据权利要求1所述的干性牙齿美白增白贴膜,其特征在于:在美白剂配方中含有过氧化物的情况下,为保证过氧化物的稳定性,所述的干性亲水高分子层中水和乙醇的总含量低于10%。
5.根据权利要求1所述的干性牙齿美白增白贴膜,其特征在于:当美白剂配方中含有过氧化物的情况下,所述干性亲水高分子层中加金属络合物稳定剂或聚乙烯吡咯烷酮形成共轭过氧键来提高过氧化物的稳定性。
6.根据权利要求5所述的干性牙齿美白增白贴膜,其特征在于:所述金属络合物稳定剂的质量含量为稳定剂的0.1%-1%,聚乙烯吡咯烷酮的质量含量为稳定剂的1%-10%;金属络合物为Na-EDTA或无钠EDTA。
7.根据权利要求1所述的干性牙齿美白增白贴膜,其特征在于:所述的干性疏水高分子层中,按质量份数计,高分子增稠剂1%-80%,保湿剂0-50%。
8.根据权利要求1所述的干性牙齿美白增白贴膜,其特征在于:所述的载体薄膜层由聚乙烯制成,厚度为0.05毫米。
9.根据权利要求1所述的干性牙齿美白增白贴膜,其特征在于:所述的干性疏水高分子层中高分子增稠剂由丙烯酸脂共聚物、聚乙烯吡咯烷酮、丙烯酸酯或辛基丙烯酰胺共聚物组成。
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