CN112955470A - 抗tnfr2抗体及其用途 - Google Patents

抗tnfr2抗体及其用途 Download PDF

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Publication number
CN112955470A
CN112955470A CN202080005657.0A CN202080005657A CN112955470A CN 112955470 A CN112955470 A CN 112955470A CN 202080005657 A CN202080005657 A CN 202080005657A CN 112955470 A CN112955470 A CN 112955470A
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antibody
sequences
cells
variable region
seq
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Inventor
赵新燕
赵晓峰
卢士强
庞然
李鑫鑫
任晋生
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Shandong Simcere Bio Pharmaceutical Co ltd
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Simcere Biological Medicine Technology Co ltd
Jiangsu Simcere Pharmaceutical Co Ltd
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/715Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
    • G01N2333/7151Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF]; for lymphotoxin [LT]

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  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
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  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

一种能够特异性地结合TNFR2的抗体或其抗原结合片段,所述抗体或其抗原结合片段能够调节免疫细胞的功能,可作为药物治疗与免疫异常有关的疾病,例如肿瘤。

Description

PCT国内申请,说明书已公开。

Claims (22)

  1. PCT国内申请,权利要求书已公开。
CN202080005657.0A 2019-08-02 2020-07-31 抗tnfr2抗体及其用途 Pending CN112955470A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910713742 2019-08-02
CN2019107137421 2019-08-02
PCT/CN2020/106057 WO2021023098A1 (zh) 2019-08-02 2020-07-31 抗tnfr2抗体及其用途

Publications (1)

Publication Number Publication Date
CN112955470A true CN112955470A (zh) 2021-06-11

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CN202080005657.0A Pending CN112955470A (zh) 2019-08-02 2020-07-31 抗tnfr2抗体及其用途

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US (1) US20220017630A1 (zh)
EP (1) EP3907240A4 (zh)
JP (1) JP7378509B2 (zh)
KR (1) KR20220038766A (zh)
CN (1) CN112955470A (zh)
AU (1) AU2020324183A1 (zh)
CA (1) CA3148881A1 (zh)
WO (1) WO2021023098A1 (zh)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023273503A1 (zh) * 2021-06-30 2023-01-05 盛禾(中国)生物制药有限公司 一种抗tnfr2单域抗体及其制备方法和应用
WO2023045606A1 (zh) * 2021-09-22 2023-03-30 上海赛金生物医药有限公司 抗tnfr2单克隆抗体及其应用
WO2023109785A1 (zh) * 2021-12-14 2023-06-22 山东先声生物制药有限公司 一种用于检测血清中sTNFR2的抗体及试剂盒
WO2024037628A1 (zh) * 2022-08-19 2024-02-22 盛禾(中国)生物制药有限公司 一种双特异性抗体及其应用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117836325A (zh) * 2021-06-22 2024-04-05 盛禾(中国)生物制药有限公司 一种抗tnfr2抗体及其制备方法和应用
TW202309096A (zh) * 2021-07-07 2023-03-01 香港商高誠生物醫藥(香港)有限公司 抗tnfr2抗體及其用途
CN116333123A (zh) * 2021-12-22 2023-06-27 宝船生物医药科技(上海)有限公司 抗tnfr2抗体及其用途
TW202333788A (zh) * 2021-12-28 2023-09-01 大陸商江蘇先聲藥業有限公司 一種抗tnfr2抗體藥物組合物
WO2023154799A1 (en) 2022-02-14 2023-08-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Combination immunotherapy for treating cancer
WO2024030888A2 (en) * 2022-08-01 2024-02-08 Yale University Tnfr2 antibodies and methods of using the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109476745A (zh) * 2016-05-13 2019-03-15 综合医院公司 拮抗性抗肿瘤坏死因子受体超家族抗体

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Publication number Priority date Publication date Assignee Title
SG10202001779UA (en) 2015-01-20 2020-04-29 Igm Biosciences Inc Tumor necrosis factor (tnf) superfamily receptor binding molecules and uses thereof
AU2016263198C1 (en) * 2015-05-15 2023-10-05 The General Hospital Corporation Antagonistic anti-tumor necrosis factor receptor superfamily antibodies
WO2017083525A1 (en) 2015-11-11 2017-05-18 Opi Vi- Ip Holdco Llc Composition and methods for anti-tnfr2 antibodies
WO2017220711A1 (en) * 2016-06-22 2017-12-28 Universite Paris Est Creteil Val De Marne Prevention or treatment of hematologic malignancy relapse using a tnfr2 antagonist
WO2019094559A2 (en) * 2017-11-09 2019-05-16 The General Hospital Corporation Antagonistic anti-tumor necrosis factor receptor superfamily polypeptides
JP2022513434A (ja) 2018-11-15 2022-02-08 ザ ジェネラル ホスピタル コーポレイション アゴニスト性腫瘍壊死因子受容体スーパーファミリーポリペプチド

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109476745A (zh) * 2016-05-13 2019-03-15 综合医院公司 拮抗性抗肿瘤坏死因子受体超家族抗体

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023273503A1 (zh) * 2021-06-30 2023-01-05 盛禾(中国)生物制药有限公司 一种抗tnfr2单域抗体及其制备方法和应用
WO2023045606A1 (zh) * 2021-09-22 2023-03-30 上海赛金生物医药有限公司 抗tnfr2单克隆抗体及其应用
WO2023109785A1 (zh) * 2021-12-14 2023-06-22 山东先声生物制药有限公司 一种用于检测血清中sTNFR2的抗体及试剂盒
WO2024037628A1 (zh) * 2022-08-19 2024-02-22 盛禾(中国)生物制药有限公司 一种双特异性抗体及其应用

Also Published As

Publication number Publication date
CA3148881A1 (en) 2021-02-11
KR20220038766A (ko) 2022-03-29
EP3907240A4 (en) 2023-02-22
AU2020324183A1 (en) 2022-03-10
WO2021023098A1 (zh) 2021-02-11
JP7378509B2 (ja) 2023-11-13
JP2022546905A (ja) 2022-11-10
EP3907240A1 (en) 2021-11-10
US20220017630A1 (en) 2022-01-20

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Address after: 264000, No.1 Heilongjiang Road, Yantai Economic and Technological Development Zone, Yantai City, Shandong Province

Applicant after: SHANDONG SIMCERE BIO-PHARMACEUTICAL Co.,Ltd.

Address before: No. 699-18 Xuanwu Avenue, Xuanwu District, Nanjing City, Jiangsu Province

Applicant before: JIANGSU SIMCERE PHARMACEUTICAL Co.,Ltd.

Applicant before: SIMCERE BIOLOGICAL MEDICINE TECHNOLOGY Co.,Ltd.