CN112936855A - General quick micro mixer based on surface curing 3D printing - Google Patents

General quick micro mixer based on surface curing 3D printing Download PDF

Info

Publication number
CN112936855A
CN112936855A CN202110134537.7A CN202110134537A CN112936855A CN 112936855 A CN112936855 A CN 112936855A CN 202110134537 A CN202110134537 A CN 202110134537A CN 112936855 A CN112936855 A CN 112936855A
Authority
CN
China
Prior art keywords
micro
channel
module
liquid inlet
straight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN202110134537.7A
Other languages
Chinese (zh)
Other versions
CN112936855B (en
Inventor
陈云飞
陈凯
张艳
江源
田云
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Southeast University
Original Assignee
Southeast University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southeast University filed Critical Southeast University
Priority to CN202110134537.7A priority Critical patent/CN112936855B/en
Publication of CN112936855A publication Critical patent/CN112936855A/en
Application granted granted Critical
Publication of CN112936855B publication Critical patent/CN112936855B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/20—Apparatus for additive manufacturing; Details thereof or accessories therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/30—Auxiliary operations or equipment
    • B29C64/307—Handling of material to be used in additive manufacturing
    • B29C64/314—Preparation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y40/00—Auxiliary operations or equipment, e.g. for material handling
    • B33Y40/10—Pre-treatment

Abstract

The invention relates to a general rapid micro-mixer based on surface curing 3D printing, which comprises a shell, wherein a liquid inlet module, a straight micro-channel module, a double-helix micro-channel module and a mixed liquid outlet module are integrated in the shell; the liquid inlet module comprises at least two inlets for inputting liquids with different concentrations; the inlet and the outlet of the straight micro-channel module are respectively connected with the outlet of the liquid inlet module and the inlet of the double-helix micro-channel module to form a passage, and the outlet of the double-helix micro-channel module is connected with the inlet of the mixed liquid outlet module to form a passage; the straight micro-channel module is provided with a straight micro-channel cavity, and a plurality of first obstacles are distributed in the straight micro-channel cavity; the double-spiral micro-channel module comprises an inflow spiral section and an outflow spiral section, each spiral section is composed of a plurality of expansion and contraction flow channels with periodically changed sectional areas, and a plurality of second obstacles are distributed in each spiral section. The invention increases the contact area and mixing length of the liquid with different concentrations, and has good mixing effect for the fluids with different Reynolds numbers.

Description

General quick micro mixer based on surface curing 3D printing
Technical Field
The invention relates to the technical field of microfluidics, in particular to a general rapid micro-mixer based on surface curing 3D printing.
Background
Microfluidics plays an increasingly important role in biochips and lab-on-a-chip applications, and efficient mixing of fluids is required to be addressed when two or more fluids undergo chemical reactions, so micromixers are an important component of microfluidic systems. Since the size of the flow channel structure of the micro mixer is small, usually in micron order, the reynolds number (reynolds number, which is the ratio between the inertial force and the viscous force when the fluid flows, and is usually the standard for determining the fluid flow state) added to the fluid is very small, and the micro mixer is in a laminar state, and molecules between adjacent flow channels are mixed in a diffusion manner.
In the prior art, most of micro mixers can achieve the mixing purpose within a single reynolds number range, for example, a straight flow channel has a good mixing effect in a low reynolds number state, and a spiral flow has a good mixing effect in a high reynolds number state, so that the universality of the micro mixer is limited. Moreover, for a single micro-channel structure, such as a straight channel, the mixing process is slow, and external power is required to be supplied continuously to overcome the huge loss of system pressure, so that the advantage of high micro-fluidic analysis speed is weakened or even disappears.
Along with the rapid development of 3D printing technology, the printing precision is higher and higher, especially based on face solidification 3D prints, and the processing breadth is big, and the precision can reach 5 microns, not only can once print traditional individual layer rectangle cross-section miniflow channel, also can realize the runner structure processing of multilayer complicated cross-section, helps realizing the design that becomes more meticulous of miniflow channel size structure, still lacks the quick mixing performance of relevant product in order to satisfy fluid under the microscale at present.
Disclosure of Invention
The invention provides a general rapid micro mixer based on surface curing 3D printing, which has universality for mixing different Rayleigh number fluids and meets the rapid mixing requirement of the fluids under a microscale.
The technical scheme adopted by the invention is as follows:
a general rapid micro-mixer based on surface curing 3D printing comprises a shell, wherein a liquid inlet module, a straight micro-channel module, a double-helix micro-channel module and a mixed liquid outlet module are integrated in the shell; the liquid inlet module comprises at least two inlets for inputting liquids with different concentrations; the inlet and the outlet of the straight micro-channel module are respectively connected with the outlet of the liquid inlet module and the inlet of the double-helix micro-channel module to form a passage, and the outlet of the double-helix micro-channel module is connected with the inlet of the mixed liquid outlet module to form a passage;
the straight micro-channel module is provided with a straight micro-channel cavity, and a plurality of first obstacles are distributed in the straight micro-channel cavity; the double-spiral micro-channel module comprises an inflow spiral section and an outflow spiral section, each spiral section is composed of a plurality of expansion and contraction flow channels with periodically changed sectional areas, and a plurality of second obstacles are distributed in each spiral section.
The further technical scheme is as follows:
each expansion and contraction flow passage is formed by connecting an expansion part and a contraction part with different section widths end to end.
The expansion part is narrow at two ends and wide in the middle to form a flow channel with the width of the cross section being changed, the radius of the expansion part is designed according to the expansion rate alpha of the flow channel, and the radius R of the inner wall of the expansion part1Outer wall radius R2The calculation formula of (a) is as follows:
R1＝Rinner+αRinner
R2＝Router-αRouter
wherein R isinner、RouterRespectively, an inner wall reference radius and an outer wall reference radius.
Each expansion and contraction flow passage is bent into a semicircle, and a plurality of expansion and contraction flow passages are connected into a spiral shape; the semi-circular radiuses are sequentially reduced from outside to inside, the two quarter circles forming a single semi-circular shape are the same in size, and the two quarter circles are symmetrical by taking the contraction part as a central axis.
The outflow spiral section has the same shape and size as the inflow spiral section.
The second barrier is of a columnar structure, and particles in the liquid can be ensured to smoothly pass through gaps between the second barrier and gaps between the second barrier and the expansion and contraction flow channel wall.
The section width range of an expansion part of the expansion and contraction flow channel is 60-100 mu m, the section width of the contraction part is 50 mu m, and the width of the second barrier is 1/20-1/12 of the section width of the expansion part.
The cross section of the straight micro-channel cavity is rectangular, trapezoidal or triangular; the first barrier is of a columnar structure, and particles in the liquid can smoothly pass through gaps between the first barrier and gaps between the first barrier and the cavity wall of the straight micro-channel.
The cross section width range of the straight micro-channel cavity is 20-50 mu m, the height of the straight micro-channel cavity is 40 mu m, the first obstacles are distributed along the length direction of the straight micro-channel cavity, and the height of the first obstacles is less than 40 mu m and more than 10 mu m.
The liquid inlet module comprises a first liquid inlet and a second liquid inlet, and the first liquid inlet, the second liquid inlet and the straight micro-channel cavity are in a T-shaped or Y-shaped cross structure; or the liquid inlet module comprises a liquid inlet 1A, a liquid inlet 1B and a liquid inlet II, and the liquid inlet 1A, the liquid inlet 1B, the liquid inlet II and the straight micro-channel cavity are in a cross structure.
The invention has the following beneficial effects:
the invention is suitable for mixing different Rayleigh number fluids, meets the requirement of quickly mixing the fluids under the microscale, and has strong universality, high mixing efficiency and good effect.
The invention combines the straight micro-channel module and the double-spiral micro-channel module, prolongs the fluid residence time and meets the mixing requirements of fluids with different Reynolds numbers.
The invention arranges the barriers in the flow channel, increases the disturbance in the flow process, and increases the contact area between the flow layers, thereby enhancing the mixing effect.
The expansion and contraction flow channel of the double-helix micro-channel module enhances the jet effect through the expansion and contraction structure, effectively reduces the pressure drop of the system, does not need external pump equipment, realizes the rapid mixing of fluids with different concentrations, and has the advantages of simple structure, convenient operation and cost reduction.
The invention adopts 3D printing and manufacturing, the modular structure is integrally formed, and the thin round tube is communicated and matched with other microfluidic devices, so that the invention can be used as a general module and a platform for chemical reaction, for example, the polymerization reaction between monomers can be realized in a mixer, and the application range is wide. The printing manufacturing precision is high, so that the micro-size and the micro-structure design are conveniently realized, meanwhile, the manufacturing time is short, the cost is low, and the large-scale production is convenient.
Drawings
Fig. 1 is a schematic perspective view of a liquid inlet module according to a first embodiment of the present invention.
Fig. 2 is a top view of fig. 1.
FIG. 3a is a partially enlarged top view of a straight microchannel module of the present invention.
FIG. 3b is an enlarged partial isometric view of a straight microchannel module of the present invention.
FIG. 4 is an enlarged, isometric view of the double helix microchannel module of FIG. 1.
FIG. 5 is a graph of the radius dimensions of a double helix microchannel module of the invention.
Fig. 6 is a schematic perspective view of a liquid inlet module according to a second embodiment of the present invention.
Fig. 7 is a front sectional view of fig. 6.
FIG. 8 is an enlarged, isometric view of the double helix microchannel module of FIG. 6.
Fig. 9 is a schematic perspective view of a liquid inlet module according to a third embodiment of the present invention.
Fig. 10 is a front sectional view of fig. 9.
FIG. 11 is an enlarged, isometric view of the double helix microchannel module of FIG. 9.
Fig. 12 is a sectional view taken along line a-a of fig. 2.
FIG. 13 is a schematic of the flow lines within a straight microchannel module of the present invention.
In the figure: 1. a housing; 2. a liquid inlet module; 3. a straight microchannel module; 4. a double helix microchannel module; 5. a mixed liquid outlet module; 21. a first liquid inlet; 22. a second liquid inlet; 211. a liquid inlet 1A; 212. a liquid inlet 1B; 31. a straight microchannel cavity; 32. a first obstacle; 41. an expansion and contraction flow channel; 42. a second obstacle; 411. an expansion part; 412. a constriction; 421. a cylindrical barrier; 422. a hexagonal prism-shaped obstacle.
Detailed Description
The following describes embodiments of the present invention with reference to the drawings.
As shown in fig. 1, the general rapid micro-mixer based on surface curing 3D printing of the present embodiment includes a housing 1, into which a liquid inlet module 2, a straight micro-channel module 3, a double helix micro-channel module 4, and a mixed liquid outlet module 5 are integrated;
the liquid inlet module 2 comprises at least two inlets for inputting liquids of different concentrations; the inlet and the outlet of the straight micro-channel module 3 are respectively connected with the outlet of the liquid inlet module 2 and the inlet of the double-helix micro-channel module 4 to form a passage, and the outlet of the double-helix micro-channel module 4 is connected with the inlet of the mixed liquid outlet module 5 to form a passage;
as shown in fig. 3a/3b, the straight micro-channel module 3 has a straight micro-channel cavity 31 in which a number of first obstacles 32 are arranged;
the cross section of the straight micro-channel cavity 31 is rectangular, trapezoidal or triangular, the first barrier 32 is a columnar structure, and particles in the liquid can be ensured to smoothly pass through gaps between the first barrier 32 and between the first barrier 32 and the wall of the straight micro-channel cavity 31.
The cross-sectional width of the straight micro-channel cavity 31 is in the range of 20-50 μm, the height is 40 μm, the first barriers 32 are distributed along the length direction of the straight micro-channel cavity 31, the height of the first barriers 32 is less than 40 μm and greater than 10 μm, and the cross-sectional dimension of the first barriers 32 can be set as low as 5 μm.
Specifically, the first barrier 32 has a cylindrical structure such as a cylinder, a triangular prism, a hexagonal prism, or a random combination of any of these structures.
As shown in fig. 3a, the first barriers 32 are triangular prism structures, distributed along the length direction of the straight micro-channel cavity 31, and arranged in two staggered rows. Parameters such as specific distribution form, number, and distance between adjacent obstacles can be debugged according to actual requirements.
As shown in fig. 4 and 8, the double spiral microchannel module 4 includes an inflow spiral section and an outflow spiral section, each of which has a plurality of expansion and contraction flow channels 41 with periodically changing cross-sectional areas, and a plurality of second obstacles 42 are disposed therein.
As shown in fig. 7 and 10, each expansion/contraction flow passage 41 is formed by connecting an expansion portion 411 and a contraction portion 412 having different sectional areas end to end.
The inflow spiral section, the expansion and contraction flow channel 41 spirals from outside to inside, the radius is gradually reduced, the outflow spiral section spirals from inside to outside, the radius is gradually increased, and the outlet of the outflow spiral section is communicated with the inlet of the inflow spiral section.
The expansion and contraction flow channel 41 is formed by connecting an expansion part 411 and a contraction part 412 with different sectional areas end to end, so that a plurality of expansion and contraction structures with wide middle parts and narrow two ends are formed, and two adjacent expansion and contraction structures are communicated at the contraction part 412.
Specifically, as shown in fig. 2, the cross section a-a is taken as a central plane, the inflow spiral section is composed of four semicircular expansion and contraction flow channels 41, the sizes of the semicircles are sequentially reduced from outside to inside, and the sizes of the microchannels of two quarter circles of each semicircle are the same and are distributed in axial symmetry with the center of the contraction part 412. In contrast, the outflow spiral section is composed of four semicircular expansion and contraction flow channels 41, and the shape and the size of the outflow spiral micro-channel are the same as those of the inflow micro-channel.
As shown in fig. 12, which is a cross-sectional view taken along section a-a of fig. 2.
As shown in fig. 5, the width of the expansion part 411 of the expansion/contraction flow path 41 is narrow at both ends and wide at the middle, the radius of the expansion part 411 is designed according to the expansion ratio α, and the radius R of the inner wall of the expansion part 411 is designed1Outer wall radius R2The calculation formula of (a) is as follows:
R1＝Rinner+αRinner
R2＝Router-αRouter
wherein R isimer、RouterRespectively, an inner wall reference radius and an outer wall reference radius.
For example, when the expansion rate α is 10%, the radius R of the inner wall of the expansion part 411 is1Is the reference radius R of the inner wallinner1.1 times of the outer wall radius R of the expansion part 4112Is the reference radius R of the outer wallouter0.9 times of the total weight of the product, and the calculation formula is as follows:
R1＝Rinner+0.1Rinner
R2＝Router-0.1Router
the meaning of the expansion ratio α can be defined in two ways:
the first method comprises the following steps:
the ratio of the difference between the outer diameter of the spiral micro-channel with the constant channel width and the outer diameter of the spiral micro-channel with the variable channel width to the outer diameter of the spiral micro-channel with the constant channel cross-sectional width. Namely:
alpha is (outer diameter of spiral micro-channel with constant cross-section width-outer diameter of spiral micro-channel with variable cross-section width)/outer diameter of spiral micro-channel with constant cross-section width multiplied by 100%
And the second method comprises the following steps:
the ratio of the difference between the inner diameter of the spiral micro-channel with the variable cross-sectional width of the flow channel and the inner diameter of the spiral micro-channel with the constant cross-sectional width to the inner diameter of the spiral micro-channel with the constant cross-sectional width. Namely:
alpha is (inner diameter of spiral micro-channel with variable cross-section width of flow channel-inner diameter of spiral micro-channel with constant cross-section width of flow channel)/inner diameter of spiral micro-channel with constant cross-section width of flow channel x 100%
Reference radius of inner wall RinnerThe physical meaning of (1): the geometric dimension of the simple annular spiral flow channel is shown, and the geometric dimension represents the inner radius (the radius of the inner wall side) of the spiral micro-flow channel with the constant flow channel section width;
outer wall reference radius RouterThe physical meaning of (1): representing the geometry of a simple toroidal helical flow channelThe cross-sectional width of the flow channel does not change near the outer radius (radius on the outer wall side) of the spiral microchannel.
The spiral micro-channel with the constant width of the cross section of the channel refers to the spiral micro-channel with a certain loop number, and the width of the channel is constant.
The spiral micro-channel with the variable cross-section width of the channel refers to a spiral micro-channel with a certain number of turns, and the width of the channel is variable.
The width of the flow passage section is widened from narrow to wide, and then the flow passage section is in a wide and narrow structure, namely an expansion and contraction structure.
Specifically, the cross-sectional width of the expansion part 411 is in the range of 60-100 μm, the cross-sectional width of the contraction part 412 is 50 μm, the width of the second obstacle 42 is 1/20-1/12 of the width of the expansion part 411, and the cross-sectional dimension of the second obstacle 42 can be set as low as 5 μm.
A certain number of second barriers 42 are randomly arranged in the inflow and outflow spiral microchannels, as shown in fig. 4, the width of the expansion and contraction flow channel 41 is small, and the distances between the second barriers 42 and between the second barriers 42 and the walls of the microchannels can be ensured to smoothly pass through particles in the liquid.
The second barrier 42 has a columnar structure such as a cylindrical shape, a triangular prism shape, a hexagonal prism shape, or the like, and may have a random combination of any of the columnar structures.
As shown in fig. 11, the second obstacle 42 of the expansion/contraction flow path 41 is a combination of a cylindrical obstacle 421 and a hexagonal prism-shaped obstacle 422.
As shown in fig. 4, the second barriers 42 of the expansion/contraction flow channel 41 have a hexagonal prism structure, and are distributed at intervals along the spiral flow channel direction, and the specific distance and number are set in an adjustable manner according to actual needs.
As shown in fig. 1, 6 and 9, there are three embodiments of the liquid inlet module 2:
as shown in fig. 2 and 12, the liquid inlet module 2 includes a first liquid inlet 21 and a second liquid inlet 22, the first liquid inlet 21 and the second liquid inlet 22 are vertically intersected, the intersection point is communicated with the straight micro-channel cavity 31, and the first liquid inlet 21, the second liquid inlet 22 and the straight micro-channel cavity 31 form a T-shaped cross structure;
as shown in fig. 7, the liquid inlet module 2 includes a first liquid inlet 21 and a second liquid inlet 22, the first liquid inlet 21 and the second liquid inlet 22 are vertically intersected, an intersection point is communicated with the straight micro-channel cavity 31, and the first liquid inlet 21, the second liquid inlet 22 and the straight micro-channel cavity 31 are in a Y-shaped intersection structure;
as shown in fig. 10, the liquid inlet module 2 includes a first liquid inlet 21 and a second liquid inlet 22, the first liquid inlet 21 includes a first liquid inlet 1a 211 and a second liquid inlet 1B 212, the first liquid inlet 1a 211 and the second liquid inlet 1B 212 are disposed opposite to each other and are disposed with the second liquid inlet 22, and the first liquid inlet 1a 211, the second liquid inlet 1B 212, the second liquid inlet 22 and the straight micro-channel cavity 31 are in a cross structure.
The mixed liquid outlet module 5 is a rectangular cross-section straight micro-channel for the mixed liquid to flow out smoothly.
The first barrier 31 and the second barrier 42 are respectively arranged in the flow channel in the embodiment, so that chaotic convection is more easily induced when fluid impacts the barriers at high speed, and the eddy current is helpful for breaking a laminar flow state, increasing the contact area and accelerating the mixing of molecules between different flow layers.
As shown in fig. 13, a schematic view of the flow lines within the straight microchannel cavity 31. As can be seen, the straight microchannel cavity 31 is divided into A, B, C, D, E five segments, wherein the flow lines indicate the specific flow direction of the fluid at different positions. When the first barrier 32 is a triangular prism, that is, a cross section is a triangle, the barrier region (ABCD) and the region without the barrier (E) have significantly different flow lines. In regions a-D, clearly curved streamlines are visible, whereas in region E only straight streamlines are visible. The barriers enable the fluid to flow in a split-polymerization-split-polymerization mode, so that the contact area and the mixing effect between the fluids are greatly improved.
At the same time, the obstructions also increase the fluid residence time. In the conventional mixer, the straight flow channel bears considerable pressure drop, when fluid flows in the straight flow channel without obstacles, the resistance is small, the system pressure drop is large, the flow speed is high, and the retention time of the fluid is short, so that molecules between flow layers cannot be sufficiently mixed in the micro flow channel with limited length. In the embodiment, the obstacles are arranged in the straight micro-channel cavity 31, so that the fluid retention time can be effectively prolonged, and the sufficient mixing is facilitated.
In addition, conventional mixers often employ a pump to continuously supply pressure to overcome pressure drop and maintain flow within a desired reynolds number range, which increases equipment cost and inconvenience operation.
Based on the above problems, the structure of the expansion portion 411 and the contraction portion 412 of the expansion and contraction flow channel 41 of the present embodiment, which are connected end to end, not only improves the mixing quality, but also reduces the pressure drop in the system, and the pressure drop is reduced by more than 60%. The expansion and contraction flow channel 41 of the double-helix micro-channel module 4 has variable width and the flow direction of each section is changed, and the structural characteristic can cause continuous disturbance of the fluid. If the flow velocity reaches the minimum when the width of the flow channel is the widest, and the flow velocity reaches the maximum when the width of the flow channel is the narrowest, the fluid flows out of the narrow slit unit at a higher speed, the jet effect is enhanced, and the pressure drop is reduced. This fluctuation may be repeated 8 to 16 times depending on the type of mixer.
At the same time, the end-to-end configuration of the expansion 411 and contraction 412 attenuates the effects of the inertial and viscous terms, with the flow in the mixer with the expanded portion covering a longer distance as the number of loops increases, e.g., to 3 loops to increase the total mixing length, as compared to a flow path without expansion. Thereby facilitating thorough mixing of the low reynolds number fluid. The straight micro-channel cavity 31 enhances the effects of the inertial and viscous terms compared to the expansion and contraction flow channel 41, thereby facilitating the thorough mixing of the high Reynolds number fluid.
In the general rapid micro-mixer based on surface curing 3D printing of the embodiment, each module is printed and formed at one time based on the surface curing 3D printing technology, the forming time is short, the precision is high, and the micro-size structural design completely different from the conventional micro-fluidic mixer structure can be realized through 3D printing.
The mixer of the embodiment is based on a surface curing 3D printing technology, so that the arrangement of a spiral flow channel structure, a micro-size flow channel, various columnar shapes and micro-size barriers becomes possible, and the mixed flowing performance and the mixing efficiency of the fluid in the mixer are greatly improved. The printing method specifically comprises the following steps: importing a mixer STL format file model into system software, and cutting the model into a certain number of two-dimensional plane models by the software at a distance of one layer thickness; by setting parameters such as exposure time and the like, the light source emits ultraviolet light, the liquid resin is projected on the surface of the liquid resin in a model slice shape by utilizing the principle of light curing of photosensitive resin, and the liquid resin is cured at the position irradiated by the light, so that the model printing with one layer thickness is realized, and the cycle is repeated until the whole model is printed; if liquid resin remains in the printed micro-channel, cleaning the micro-channel by using alcohol; if the model is fully cured, ultraviolet light is needed for secondary light curing.
The general rapid micro-mixer based on surface curing 3D printing of the embodiment has the following working procedures:
as shown in fig. 2, two different liquids flow in from the first liquid inlet 21 and the second liquid inlet 22 at a given flow rate, and flow into the straight micro-channel cavity 31 after being mixed at a T-shaped intersection, particles in the two different liquids are accelerated to be diffused and mixed under the collision of the first obstacle 32 in the straight micro-channel cavity 31, and then enter the inflow spiral section of the double-spiral micro-channel module 4, and under the asymmetric flow and collision of the expansion and contraction flow channel 41 and the collision of the second obstacle 42, the liquids are continuously and sufficiently mixed, and flow out through the outflow spiral section, and finally, the uniformly mixed liquid flows out from the outlet of the mixed liquid outlet module 5.
Similarly, as shown in fig. 10, two liquid inlets are included, one of which flows in from the liquid inlet 1a 211 and the liquid inlet 1B 212, and the other of which flows in from the liquid inlet two 22, the two liquids intersect vertically and are in a cross shape, and then flow into the straight microchannel cavity 31 from the cross-shaped intersection, and the subsequent flow process and principle are the same.
The embodiment adopts the technical scheme that the straight flow channel, the spiral flow channel with the expansion and contraction structure and the barriers in the flow channel are combined, the collision and the flow distribution of the barriers to the fluid of each flow layer are integrated, the inertia and the viscosity of the fluid of each flow layer are weakened by the spiral flow channel, the influence of the increase of the number of spiral loops on the increase of the mixing length is realized, the contact area and the mixing length of the liquids with different concentrations are increased, and the good mixing effect is realized on the fluids with different Reynolds numbers.

Claims (10)

1. A general rapid micro-mixer based on surface curing 3D printing is characterized by comprising a shell (1), wherein a liquid inlet module (2), a straight micro-channel module (3), a double-helix micro-channel module (4) and a mixed liquid outlet module (5) are integrated in the shell; the liquid inlet module (2) comprises at least two inlets for inputting liquids of different concentrations; the inlet and the outlet of the straight micro-channel module (3) are respectively connected with the outlet of the liquid inlet module (2) and the inlet of the double-helix micro-channel module (4) to form a passage, and the outlet of the double-helix micro-channel module (4) is connected with the inlet of the mixed liquid outlet module (5) to form a passage;
the straight micro-channel module (3) is provided with a straight micro-channel cavity (31) in which a plurality of first obstacles (32) are distributed; the double-spiral micro-channel module (4) comprises an inflow spiral section and an outflow spiral section, each spiral section is composed of a plurality of expansion and contraction flow channels (41) with periodically changed sectional areas, and a plurality of second obstacles (42) are distributed in each spiral section.
2. The universal rapid micromixer based on surface-curing 3D printing according to claim 1, characterized in that each expansion-contraction flow channel (41) is formed by connecting end-to-end expansion sections (411) and contraction sections (412) of different cross-sectional widths.
3. The general rapid micromixer based on surface curing 3D printing according to claim 2, characterized in that said bulge (411) has narrow ends and wide middle to form a flow channel with variable cross-sectional width, the radius of said bulge (411) is designed according to the expansion rate α of the flow channel, and the radius R of the inner wall of said bulge (411) is1Outer wall radius R2The calculation formula of (a) is as follows:
R1＝Rinner+αRinner
R2＝Router-αRouter
wherein R isinner、RouterRespectively, an inner wall reference radius and an outer wall reference radius.
4. The universal rapid micromixer based on surface-curing 3D printing according to claim 3, characterized in that each expansion-contraction flow channel (41) is curved in a semicircular shape, and a plurality of expansion-contraction flow channels (41) are connected in a spiral shape; the semi-circle radius decreases from outside to inside in turn, the two quarter circles forming a single semi-circle have the same size, and are symmetrical by taking the contraction part (412) as a central axis.
5. The face cure 3D printing based universal rapid micromixer according to claim 3, wherein the shape and size of said outflow spiral segment is the same as that of said inflow spiral segment.
6. The universal rapid micromixer based on surface curing 3D printing according to claim 3, characterized in that the second obstacles (42) are columnar structures, ensuring the smooth passage of particles in the liquid from the gaps between the second obstacles (42) and between the second obstacles (42) and the walls of the expansion and contraction flow channel (41).
7. The universal rapid micromixer based on surface curing 3D printing according to claim 6, characterized in that the cross-sectional width of the expansion part (411) of said expansion-contraction flow channel (41) is in the range of 60-100 μm, the cross-sectional width of said contraction part (412) is 50 μm, and the width of said second obstacle (42) is 1/20-1/12 of the cross-sectional width of said expansion part (411).
8. The universal fast micromixer based on area curing 3D printing according to claim 2, characterized in that said straight microchannel cavities (31) are rectangular, trapezoidal or triangular in cross-sectional shape; the first barrier (32) is of a columnar structure, and particles in the liquid can be ensured to smoothly pass through gaps between the first barrier (32) and gaps between the first barrier (32) and the walls of the straight micro-channel cavity (31).
9. The universal fast micromixer based on area curing 3D printing according to claim 7, characterized in that said straight microchannel cavity (31) has a cross-sectional width in the range of 20-50 μ ι η and a height of 40 μ ι η, first obstacles (32) are distributed along the length direction of said straight microchannel cavity (31), and the height of first obstacles (32) is less than 40 μ ι η and greater than 10 μ ι η.
10. The universal rapid micromixer based on surface curing 3D printing according to claim 2, characterized in that the liquid inlet module (2) comprises a first liquid inlet (21) and a second liquid inlet (22), the first liquid inlet (21), the second liquid inlet (22) and the straight microchannel cavity (31) are in a T-shaped or Y-shaped cross structure; or the liquid inlet module (2) comprises a liquid inlet 1A (211), a liquid inlet 1B (212) and a liquid inlet II (22), and the liquid inlet 1A (211), the liquid inlet 1B (212), the liquid inlet II (22) and the straight micro-channel cavity (31) are in a cross structure.
CN202110134537.7A 2021-01-29 2021-01-29 General quick micro mixer based on surface curing 3D prints Active CN112936855B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110134537.7A CN112936855B (en) 2021-01-29 2021-01-29 General quick micro mixer based on surface curing 3D prints

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202110134537.7A CN112936855B (en) 2021-01-29 2021-01-29 General quick micro mixer based on surface curing 3D prints

Publications (2)

Publication Number Publication Date
CN112936855A true CN112936855A (en) 2021-06-11
CN112936855B CN112936855B (en) 2022-05-24

Family

ID=76240418

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202110134537.7A Active CN112936855B (en) 2021-01-29 2021-01-29 General quick micro mixer based on surface curing 3D prints

Country Status (1)

Country Link
CN (1) CN112936855B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112611991A (en) * 2020-12-21 2021-04-06 浙江大学 double-D type optical fiber weak magnetic field sensor with double-helix structure and manufacturing method thereof
CN112611990A (en) * 2020-12-14 2021-04-06 浙江大学 Disc-shaped microstructure magnetic field sensor based on multi-material 3D printing technology
CN112763944A (en) * 2020-12-14 2021-05-07 浙江大学 Disc-shaped probe type magnetic field sensor based on 3D printing technology and manufacturing method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200600185A (en) * 2004-06-28 2006-01-01 Jing-Tang Yang The micromixer with saddle point modulation
CN103638853A (en) * 2013-11-11 2014-03-19 江苏大学 S-type passive micro-mixer
CN104797340A (en) * 2012-09-21 2015-07-22 麻省理工学院 Micro-fluidic device and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200600185A (en) * 2004-06-28 2006-01-01 Jing-Tang Yang The micromixer with saddle point modulation
CN104797340A (en) * 2012-09-21 2015-07-22 麻省理工学院 Micro-fluidic device and uses thereof
CN103638853A (en) * 2013-11-11 2014-03-19 江苏大学 S-type passive micro-mixer

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112611990A (en) * 2020-12-14 2021-04-06 浙江大学 Disc-shaped microstructure magnetic field sensor based on multi-material 3D printing technology
CN112763944A (en) * 2020-12-14 2021-05-07 浙江大学 Disc-shaped probe type magnetic field sensor based on 3D printing technology and manufacturing method thereof
CN112611990B (en) * 2020-12-14 2022-04-08 浙江大学 Disc-shaped microstructure magnetic field sensor based on multi-material 3D printing technology
CN112611991A (en) * 2020-12-21 2021-04-06 浙江大学 double-D type optical fiber weak magnetic field sensor with double-helix structure and manufacturing method thereof
CN112611991B (en) * 2020-12-21 2022-04-22 浙江大学 double-D type optical fiber weak magnetic field sensor with double-helix structure and manufacturing method thereof

Also Published As

Publication number Publication date
CN112936855B (en) 2022-05-24

Similar Documents

Publication Publication Date Title
CN112936855B (en) General quick micro mixer based on surface curing 3D prints
JP6674933B2 (en) Process-enhanced microfluidic device
Sudarsan et al. Fluid mixing in planar spiral microchannels
US7753580B2 (en) Microstructure designs for optimizing mixing and pressure drop
US7794136B2 (en) Twin-vortex micromixer for enforced mass exchange
Yang et al. Design and fabrication of a three dimensional spiral micromixer
AU2013220890B2 (en) Centrifugal microfluidic mixing apparatus and method
CN210906104U (en) Micro-reaction channel and micro-reactor
KR20100060476A (en) Passive micromixer
TWI230683B (en) The micromixer with overlapping-crisscross entrance
KR102014601B1 (en) Three-dimensional flow structure microfluidic mixer
KR101432729B1 (en) Micromixer with circular chambers and crossing constriction channels
CN109985543B (en) Spindle-shaped passive micro mixer
Vijayanandh et al. Design and simulation of passive micromixers with ridges for enhanced efficiency
CN110975776B (en) Microfluid mixing channel, microfluid control device and microreactor
JP2008246283A (en) Collision type micromixer
CN110947329A (en) Sawtooth type passive micro mixer
CN108325483B (en) Microporous vortex sleeve reactor and application thereof
Shin et al. Design and evaluation of a 3D multi-manifold micromixer realized by a double-Archimedes-screw for rapid mixing within a short distance
TWI450852B (en) Micromixer
KR100880005B1 (en) Split and recombine micro-mixer with chaotic mixing
CN217042339U (en) Quick micro-mixer with variable cross section
CN105148781B (en) A kind of cross micro-mixer of axial symmetry log spiral
KR102324465B1 (en) Microfluidic mixer and method of mixing fluid using the same
TWI268804B (en) The impinging micromixer with swirling inlet ports

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant