CN112933205A - 一种治疗骨性关节炎的药物组合物及其制备方法 - Google Patents
一种治疗骨性关节炎的药物组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗骨性关节炎的药物组合物及其制备方法,该药物组合物由以下重量份数的原料组分制备而成:栀子10‑20份、当归10‑30份、大黄10‑20份、丹参10‑40份、川芎10‑30份、龙血竭10‑20份、甘草10‑30份、白芷10‑25份、麻黄10‑30份、桂枝10‑30份、防风10‑20份、鸡血藤10‑30份、白芍5‑20份、红花15‑40份、没药5‑20份、乳香10‑20份、八角茴香10‑25份、透骨草5‑15份、伸筋草5‑20份、黄芪10‑30份、苍耳子10‑30份、川断10‑20份、生姜10‑20份、三七10‑30份、桃仁10‑30份、两面针10‑25,该药物组合物遵循君臣佐使配伍原则,精选药物组方,具有活血调气、强筋健骨、散瘀活血、通经活络等疗效,且该药物组合物对人体无损伤、配制简便、药源广泛、成本低、疗效显著且无毒副作用,能够有效治疗骨性关节炎疾病。
Description
技术领域
本发明属于中药技术领域,具体涉及一种治疗骨关节病的药物组合物及其制备方法。
背景技术
骨性关节炎(osteoarthritis,OA)是一种常见的慢性关节疾病,其主要病变是关节软骨的退行性变和继发性骨质增生。退行性骨关节病是指人体出现的一系列退行性病变,如关节疼痛、僵硬及活动受限等,是一种综合性疾病。其在50岁以上的人群中,发病率仅次于心脏病,在65岁以上人群中的发病率高达60-90%,特别是给中老年人的生活带来了极大的痛苦及不便。
目前治疗膝关节骨性关节炎的方法多种多样,可分为非手术疗法和手术疗法。中医认为:肝主筋,肾主骨,肝肾充盈则筋劲强,关节滑利,在中年以年,肝肾逐渐亏虚,肾气不足,筋骨失其所养,筋软骨萎,或兼遭风寒湿邪内侵,易发本病。若膝部外伤、劳损,气血运行不畅,经脉受阻,致使筋骨失养而发病。
本病发病率很高,现代医学可以进行关节置换手术,但大多数人不欲接受而且无法承担手术的巨额花费,中西药目前也无特效根治的方法,且治疗药物多为内服药,刺激胃、肠道的同时并对肝肾造成损害,毒副作用较大。
发明内容
本发明的目的在于:针对以上现有技术所述现有治疗骨性关节炎的方法所存在的技术问题,以及为了进一步丰富治疗骨性关节炎的中药药物,本发明提供一种治疗骨性关节炎的药物组合物及其制备方法,该药物组合物遵循君臣佐使配伍原则,精选药物组方,具有活血调气、强筋健骨、散瘀活血、通经活络等疗效,且该药物组合物对人体无损伤、配制简便、药源广泛、成本低、疗效显著且无毒副作用,能够有效治疗骨性关节炎疾病。
本发明采用的技术方案如下:一种治疗骨性关节炎的药物组合物,以重量份数计,该药物组合物由以下重量份数的原料组分制备而成:栀子10-20份、当归10-30份、大黄10-20份、丹参10-40份、川芎10-30份、龙血竭10-20份、甘草10-30份、白芷10-25份、麻黄10-30份、桂枝10-30份、防风10-20份、鸡血藤10-30份、白芍5-20份、红花15-40份、没药5-20份、乳香10-20份、八角茴香10-25份、透骨草5-15份、伸筋草5-20份、黄芪10-30份、苍耳子10-30份、川断10-20份、生姜10-20份、三七10-30份、桃仁10-30份、两面针10-25份。
优选地,以上所述药物组合物由以下重量份数的原料组分制备而成:栀子15-20份、当归20-30份、大黄15-20份、丹参20-30份、川芎15-25份、龙血竭15-20份、甘草15-25份、白芷15-20份、麻黄15-25份、桂枝15-25份、防风15-20份、鸡血藤20-26份、白芍15-20份、红花20-30份、没药15-20份、乳香15-18份、八角茴香15-20份、透骨草10-15份、伸筋草15-20份、黄芪20-30份、苍耳子10-20份、川断10-15份、生姜10-15份、三七15-20份、桃仁10-15份、两面针10-20份。
优选地,以上所述药物组合物由以下重量份数的原料组分制备而成:栀子16份、当归25份、大黄18份、丹参25份、川芎20份、龙血竭20份、甘草20份、白芷15份、麻黄20份、桂枝20份、防风20份、鸡血藤25份、白芍20份、红花25份、没药20份、乳香15份、八角茴香20份、透骨草15份、伸筋草20份、黄芪25份、苍耳子15份、川断14份、生姜15份、三七20份、桃仁15份、两面针15份。
以上所述药物组合物,具体药理如下:
所述栀子:苦,寒;归心、肺、三焦经,具有泻火除烦,清热利湿,凉血解毒的功效,外用消肿止痛;所述当归:味甘、辛、性温,归肝、心、脾经,具有补血活血,调经止痛,润肠通便的功效,用于血虚萎黄,眩晕心悸,月经不调,经闭痛经,虚寒腹痛,风湿痹痛,跌扑损伤,痈疽疮疡,肠燥便秘,活血通经,用于经闭痛经,风湿痹痛,跌扑损伤;所述大黄:《本经》:味苦,寒;功能主治:泻热毒,破积滞,行瘀血。治实热便秘,谵语发托,食积痞满,痢疾初起,里急后重,瘀停经闭,症瘕积聚,时行热疫,暴眼赤痛,吐血,衄血,阳黄,水肿,淋浊,溲亦,痈疡肿毒,疔疮,汤火伤,泻热通肠,凉血解毒,逐瘀通经,用于实热便秘、积滞腹痛、泻痢不爽、湿热黄疸;
所述丹参:味苦,微寒;归心、肝经;功效:活血祛瘀,通经止痛,清心除烦,凉血消痈;主治:用于胸痹心痛,脘腹胁痛,症瘕积聚,热痹疼痛,心烦不眠,月经不调,痛经经闭,疮疡肿痛;所述川芎:辛,温;入肝、胆经;功能主治:行气开郁,祛除风燥湿,活血止痛。治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。用于月经不调,经闭痛经,瘕腹痛,胸胁刺痛,跌扑肿痛,头痛,风湿痹痛;所述龙血竭:甘、辛、咸、平;归肺、脾、肾经;具有活血散瘀,定痛止血,敛疮生肌的功效;
所述甘草:甘草具有补脾益气、清热解毒、祛痰止咳、调和诸药的功效;所述白芷:辛,温;入肺、脾、胃经;具有祛风,燥湿,消肿,止痛之功效,治头痛,眉棱骨痛,齿痛,鼻渊,寒湿腹痛;所述麻黄辛,微苦,温;归肺、膀胱经;具有发汗散寒,宣肺平喘,利水消肿的功效;所述桂枝、防风:具有辛温发散,能祛风寒湿邪,温通经络,缓解疼痛;
所述鸡血藤:具有祛风活血、舒筋活络之功效,主治:腰膝酸痛、麻木瘫痪;所述白芍:味辛、苦、性温;有小毒;具有温阳祛湿、补体虚、健脾胃等功效;所述红花:辛、温,入心、肝经,具有活血化瘀,散湿去肿的功效;所述没药:味辛、苦、性平,归心、肝、脾经,具有散瘀定痛,消肿生肌之功效;治各种瘀血阻滞之痛症,如跌打损伤,症见伤处疼痛,伤筋动骨或麻木酸胀,或内伤瘀血,心腹疼痛,肢臂疼痛等症,一般与没药、乳香、丹参、当归等配伍使用;
所述乳香:辛、苦、温,归心、肝、脾经,具有活血行气止痛,消肿生肌的功效;所述八角茴香:性温、味辛,归肝、肾、脾、胃经,具有温阳、散寒、理气、寒疝腹痛,肾虚腰痛的功效;所述透骨草:甘、辛、温,入肺、肝二经,具有活血化瘀、舒筋活络、活血止痛、通经透骨之功效;所述伸筋草:味苦、微辛、性温,有祛风除湿,舒筋活络的功效;
所述黄芪:味甘、性微温,具有益正气,壮脾胃,排脓止痛,活血医危的功效;所述苍耳子:味苦、甘、辛、性温,具有发散风寒,通鼻窍,祛风湿,止痛的功效;所述川断:补肝肾,续筋骨,调血脉,具有治疗腰背酸痛、足膝无力、崩漏、跌打损伤、痈疽疮肿的功效所述三七:以其根部入药,其性温,味辛,具有显著的活血化瘀、消肿定痛功效,有“金不换”、“南国神草”之美誉;所述桃仁:苦、甘、平,归心、肝、大肠经,具有活血祛瘀,润肠通便,止咳平喘的功效;所述两面针:味苦、辛、性平,归肝、胃经,具有活血化瘀、行气止痛、祛风通络解毒消肿的功效。
以上所述药物组合物组方合理,具有活血祛瘀,通络止痛,祛风除湿之功效,还可治疗肝肾亏虚,肾气不足等。
以上所述药物组合物可以制备的药物剂型为:熏蒸药汤、软膏剂、酊剂或洗剂。
为更好的实现本发明目的,本发明还提供一种治疗骨性关节炎的药物组合物的制备方法,具体包括步骤:
将所述药物组合物制备为熏蒸药汤的制备方法:按照相应重量份原料组分的配方,称取所述重量份配比的各原料组分,将称取的各原料组分投入到煎煮容器中,向煎煮容器中添加水浸泡45分钟-60分钟,加水量为各原料组分总重量的7-10倍,然后大火煎煮至水沸15-30分钟,接着加入陈醋,陈醋加入量为:1kg原料组分总重量添加500ml醋,即添加量为500ml/kg,为再度烧开煮沸后制得本发明药汤,用本发明药汤的蒸汽熏蒸患处10-15分钟,熏蒸后,用本发明药汤淋浇患处或将患处浸泡于药汤内即可。
将所述药物组合物制备为软膏剂的制备方法:按照相应重量份原料组分的配方,称取所述重量份配比的各原料组分,加水提取2-3次,每次加水量相当于药材总重量的8-10倍,每次提取时间为1.5-2.5小时,合并三次提取液,过滤,将滤液浓缩至80℃下相对密度为1.10-1.30kg/m3的浸膏,加入乙醇,使其含醇量为40-70%,静置12-24小时,滤过,滤液浓缩至80℃时相对密度为1.10-1.25kg/m3的浸膏,干燥,粉碎,与适量的水溶性基质配合,搅拌均匀,即得本发明药物组合物的软膏剂。
将所述药物组合物制备为酊剂的制备方法:照相应重量份原料组分的配方,称取所述重量份配比的各原料组分,对称取的各原料组分进行浸渍提取3-4次,每次加入药材总重量3-5倍的50-90%的乙醇浸渍15-60小时,倾取上清液,压榨药渣,合并三次上清液和压榨液,过滤,浓缩至相当于药材总重量4~6倍,过滤,分装,密封,即得本发药物组合物的酊剂。
将所述药物组合物制备为洗剂的制备方法:照相应重量份原料组分的配方,称取所述重量份配比的各原料组分,加入相当于各原料组分总重量1~2倍的40%~60%的乙醇浸渍12~48小时,然后用40%~60%的乙醇以每分钟约占原料总重量0.2%~0.6%的速度进行渗漉,收集相当于各原料组分总重量5-10倍量的渗漉液,回收乙醇,减压浓缩至相当于各原料组分总重量的1~2倍,过滤,得到药液,该药液即为活性成分,在活性成分中加入甘油,即制成本发明药物组合物的洗剂。
相较于现有技术,本发明的有益效果是:本发明精选药物组方,其药物组分经辩证配伍,在作用上相互佐助,共同起到补肝健脾、温经散寒、祛湿化瘀、补血活血、舒筋通络的功效,对骨性关节炎的治疗达到标本兼治的效果,且该药物组合物为外用药,对人体无损伤、配制简便、药源广泛、成本低、疗效显著且无毒副作用,能够有效治疗骨性关节炎疾病,能创造较好的社会价值及经济利益。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白,对本发明进行进一步详细说明。应当理解,此处所描述的具体实施例仅用以解释本发明,并不用于限定本发明,即所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。
实施例1
一种治疗骨性关节炎的药物组合物,以重量份数计,该药物组合物由以下重量份数的原料组分制备而成:栀子16份、当归25份、大黄18份、丹参25份、川芎20份、龙血竭20份、甘草20份、白芷15份、麻黄20份、桂枝20份、防风20份、鸡血藤25份、白芍20份、红花25份、没药20份、乳香15份、八角茴香20份、透骨草15份、伸筋草20份、黄芪25份、苍耳子15份、川断14份、生姜15份、三七20份、桃仁15份、两面针15份。
以一份为1kg为计,一种治疗骨性关节炎的药物组合物,该药物组合物由以下重量的原料组分制备而成:栀子16kg、当归25kg、大黄18kg、丹参25kg、川芎20kg、龙血竭20kg、甘草20kg、白芷15kg、麻黄20kg、桂枝20kg、防风20kg、鸡血藤25kg、白芍20kg、红花25kg、没药20kg、乳香15kg、八角茴香20kg、透骨草15kg、伸筋草20kg、黄芪25kg、苍耳子15kg、川断14kg、生姜15kg、三七20kg、桃仁15kg、两面针15kg。
将以上配方的药物组合物制备为熏蒸药汤的制备方法:将称取的各原料组分投入到煎煮容器中,向煎煮容器中添加水浸泡45分钟-60分钟,加水量为各原料组分总重量的7-10倍,然后大火煎煮至水沸15-30分钟,接着加入陈醋,陈醋加入量为:1kg原料组分总重量添加500ml醋,即添加量为500ml/kg,为再度烧开煮沸后制得本发明药汤,用本发明药汤的蒸汽熏蒸患处10-15分钟,熏蒸后,用本发明药汤淋浇患处或将患处浸泡于药汤内即可。
将以上配方的药物组合物制备为软膏剂的制备方法:称取所述重量份配比的各原料组分,加水提取2-3次,每次加水量相当于药材总重量的8-10倍,每次提取时间为1.5-2.5小时,合并三次提取液,过滤,将滤液浓缩至80℃下相对密度为1.10-1.30kg/m3的浸膏,加入乙醇,使其含醇量为40-70%,静置12-24小时,滤过,滤液浓缩至80℃时相对密度为1.10-1.25kg/m3的浸膏,干燥,粉碎,与适量的水溶性基质配合,搅拌均匀,即得本发明药物组合物的软膏剂。
将以上配方的药物组合物制备为酊剂的制备方法:对称取的各原料组分进行浸渍提取3-4次,每次加入药材总重量3-5倍的50-90%的乙醇浸渍15-60小时,倾取上清液,压榨药渣,合并三次上清液和压榨液,过滤,浓缩至相当于药材总重量4~6倍,过滤,分装,密封,即得本发药物组合物的酊剂。
将以上配方的药物组合物制备为洗剂的制备方法:称取所述重量份配比的各原料组分,向其加入相当于各原料组分总重量1~2倍的40%~60%的乙醇浸渍12~48小时,然后用40%~60%的乙醇以每分钟约占原料总重量0.2%~0.6%的速度进行渗漉,收集相当于各原料组分总重量5-10倍量的渗漉液,回收乙醇,减压浓缩至相当于各原料组分总重量的1~2倍,过滤,得到药液,该药液即为活性成分,在活性成分中加入甘油,即制成本发明药物组合物的洗剂。
实施例2
一种治疗骨性关节炎的药物组合物,以重量份数计,该药物组合物由以下重量份数的原料组分制备而成:栀子20份、当归30份、大黄20份、丹参40份、川芎30份、龙血竭20份、甘草30份、白芷25份、麻黄30份、桂枝30份、防风20份、鸡血藤30份、白芍20份、红花40份、没药20份、乳香20份、八角茴香25份、透骨草15份、伸筋草20份、黄芪30份、苍耳子30份、川断20份、生姜20份、三七30份、桃仁30份、两面针25份
以一份为1kg计,一种治疗骨性关节炎的药物组合物,该药物组合物由以下重量的原料组分制备而成:栀子20kg、当归30kg、大黄20kg、丹参40kg、川芎30kg、龙血竭20kg、甘草30kg、白芷25kg、麻黄30kg、桂枝30kg、防风20kg、鸡血藤30kg、白芍20kg、红花40kg、没药20kg、乳香20kg、八角茴香25kg、透骨草15kg、伸筋草20kg、黄芪30kg、苍耳子30kg、川断20kg、生姜20kg、三七30kg、桃仁30kg、两面针25kg。
将以上配方的药物组合物制备为熏蒸药汤的制备方法:同实施例1;
将以上配方的药物组合物制备为软膏剂的制备方法:同实施例1;
将以上配方的药物组合物制备为酊剂的制备方法:同实施例1;
将以上配方的药物组合物制备为洗剂的制备方法:同实施例1。
实施例3
一种治疗骨性关节炎的药物组合物,以重量份数计,该药物组合物由以下重量份数的原料组分制备而成:栀子10份、当归10份、大黄10份、丹参10份、川芎10份、龙血竭10份、甘草10份、白芷10份、麻黄10份、桂枝10份、防风10份、鸡血藤10份、白芍5份、红花15份、没药5份、乳香10份、八角茴香10份、透骨草5份、伸筋草5份、黄芪10份、苍耳子10份、川断10份、生姜10份、三七10份、桃仁10份、两面针10份。
以一份为1kg计,一种治疗骨性关节炎的药物组合物,该药物组合物由以下重量的原料组分制备而成:栀子10份kg、当归10kg、大黄10kg、丹参10kg、川芎10kg、龙血竭10kg、甘草10kg、白芷10kg、麻黄10kg、桂枝10kg、防风10kg、鸡血藤10kg、白芍5kg、红花15kg、没药5kg、乳香10kg、八角茴香10kg、透骨草5kg、伸筋草5kg、黄芪10kg、苍耳子10kg、川断10kg、生姜10kg、三七10kg、桃仁10kg、两面针10kg。
将以上配方的药物组合物制备为熏蒸药汤的制备方法:同实施例1;
将以上配方的药物组合物制备为软膏剂的制备方法:同实施例1;
将以上配方的药物组合物制备为酊剂的制备方法:同实施例1;
将以上配方的药物组合物制备为洗剂的制备方法:同实施例1。
实施例4
一种治疗骨性关节炎的药物组合物,以重量份数计,该药物组合物由以下重量份数的原料组分制备而成:栀子15份、当归20份、大黄15份、丹参20份、川芎15份、龙血竭15份、甘草15份、白芷20份、麻黄15份、桂枝15份、防风15份、鸡血藤20份、白芍15份、红花20份、没药15份、乳香18份、八角茴香15份、透骨草10份、伸筋草15份、黄芪20份、苍耳子20份、川断15份、生姜10份、三七15份、桃仁10份、两面针20份。
一种治疗骨性关节炎的药物组合物,该药物组合物由以下重量的原料组分制备而成:栀子15kg、当归20kg、大黄15kg、丹参20kg、川芎15kg、龙血竭15kg、甘草15kg、白芷20kg、麻黄15kg、桂枝15kg、防风15kg、鸡血藤20kg、白芍15kg、红花20kg、没药15kg、乳香18kg、八角茴香15kg、透骨草10kg、伸筋草15kg、黄芪20kg、苍耳子20kg、川断15kg、生姜10kg、三七15kg、桃仁10kg、两面针20kg。
将以上配方的药物组合物制备为熏蒸药汤的制备方法:同实施例1;
将以上配方的药物组合物制备为软膏剂的制备方法:同实施例1;
将以上配方的药物组合物制备为酊剂的制备方法:同实施例1;
将以上配方的药物组合物制备为洗剂的制备方法:同实施例1。
临床治疗总结
该实施例以实施例1所给出的一种治疗骨性关节炎的药物组合物,做临床疗效总结如下:
1、一般性资料:本药物组合物应用与临床观察病理60例,男30例,女30例,年龄40-70岁。
2、诊断依据:参照1994年国家中医药管理局《中医病证诊断疗效标准》制定的骨性关节炎诊断标准:(1)多为中老年人;(2)反复发作的关节周围疼痛,关节负重时疼痛加重,时有肿胀;(3)屈伸关节时多有粗糙的关节摩擦音;(4)X线示关节边缘骨赘,关节间隙明显变窄;(5)除外类风湿性关节炎。
3、疗效标准:参照1994年国家中医药管理局《中医病证诊断疗效标准》制定的骨性关节炎疗效评定标准:(1)治愈:疼痛消失,关节活动功能恢复正常;(2)显效:疼痛明显减轻,关节活动功能改;(3)有效:疼痛有所减轻,关节活动有所改善;(4)无效:关节疼痛及活动范围无改善。
4、用法用量:临床应用时,药物组合物的用量根据患者的体重和年龄酌情增减,取实施例制备得到的药物组合物(包括熏蒸药汤、软膏剂、酊剂或洗剂),一日4-5次,分早、晚两次对病例病发处进行外用熏洗或擦拭,根据药物的不同剂型,根据临床常规用法对病例的患处进行处理治疗,六天为一疗程。
5、治疗效果:对临床观察病例进行为期半年的治疗,痊愈者40例,随访未见复发,显效者6例,有效3例,无效1例,治疗期间未发生毒副作用,总有效率为98%。
典型病例
病例1:张某,女,45岁。2年前出现双膝关节疼痛,活动受限,拍X线片报告显示:髁间出现骨刺,关节间隙变窄,确诊为:骨性关节炎。曾口服美洛昔康、对乙酰氨基酚等药物治疗,但效果不佳。近一年来双膝关节疼痛加重,通过本发明提供的技术方案制备得到的药物组合物进行治疗,治疗疗程3个月,自觉双膝关节疼痛较前明显减轻,继续坚持治疗至6个月,疼痛消失,关节活动功能恢复正常,治愈。
病例2:汤某,女,50岁。双膝肿胀、乏力、疼痛,下蹲受限,后期出现双膝关节的肿胀、疼痛症状加剧,X线示关节边缘骨赘,关节间隙明显变窄,确诊为:骨性关节炎,通过本发明提供的技术方案制备得到的药物组合物进行治疗4个月,双膝关节疼痛、肿胀大大减轻,下蹲功能明显改善;继续坚持治疗至6个月,双膝肿胀、乏力、疼痛已消失,下蹲及其他活动功能恢复正常,随访半年未复发。
以上所述实施例仅表达了本申请的具体实施方式,其描述较为具体和详细,但并不能因此而理解为对本申请保护范围的限制。应当指出的是,对于本领域的普通技术人员来说,在不脱离本申请技术方案构思的前提下,还可以做出若干变形和改进,这些都属于本申请的保护范围。
Claims (8)
1.一种治疗骨性关节炎的药物组合物,其特征在于,所述药物组合物由以下重量份数的原料组分制备而成:栀子10-20份、当归10-30份、大黄10-20份、丹参10-40份、川芎10-30份、龙血竭10-20份、甘草10-30份、白芷10-25份、麻黄10-30份、桂枝10-30份、防风10-20份、鸡血藤10-30份、白芍5-20份、红花15-40份、没药5-20份、乳香10-20份、八角茴香10-25份、透骨草5-15份、伸筋草5-20份、黄芪10-30份、苍耳子10-30份、川断10-20份、生姜10-20份、三七10-30份、桃仁10-30份、两面针10-25份。
2.根据权利要求1所述的一种治疗骨性关节炎的药物组合物,其特征在于,所述药物组合物由以下重量份数的原料组分制备而成:栀子15-20份、当归20-30份、大黄15-20份、丹参20-30份、川芎15-25份、龙血竭15-20份、甘草15-25份、白芷15-20份、麻黄15-25份、桂枝15-25份、防风15-20份、鸡血藤20-26份、白芍15-20份、红花20-30份、没药15-20份、乳香15-18份、八角茴香15-20份、透骨草10-15份、伸筋草15-20份、黄芪20-30份、苍耳子10-20份、川断10-15份、生姜10-15份、三七15-20份、桃仁10-15份、两面针10-20份。
3.根据权利要求1所述的一种治疗骨性关节炎的药物组合物,其特征在于,所述药物组合物由以下重量份数的原料组分制备而成:栀子16份、当归25份、大黄18份、丹参25份、川芎20份、龙血竭20份、甘草20份、白芷15份、麻黄20份、桂枝20份、防风20份、鸡血藤25份、白芍20份、红花25份、没药20份、乳香15份、八角茴香20份、透骨草15份、伸筋草20份、黄芪25份、苍耳子15份、川断14份、生姜15份、三七20份、桃仁15份、两面针15份。
4.根据权利要求1所述的一种治疗骨性关节炎的药物组合物,其特征在于,所述药物组合物可以制备的药物剂型为:熏蒸药汤、软膏剂、酊剂或洗剂。
5.基于权利要求1-4所述的任意一种治疗骨性关节炎的药物组合物的制备方法,其特征在于,将所述药物组合物制备为熏蒸药汤的制备方法包括如下步骤:称取所述重量份配比的各原料组分,将称取的各原料组分投入到煎煮容器中,向煎煮容器中添加水进行浸泡,然后大火煎煮至水沸保持一段时间,接着加入陈醋,为再度烧开煮沸后制得本发明熏蒸药汤。
6.基于权利要求1-4所述的任意一种治疗骨性关节炎的药物组合物的制备方法,其特征在于,将所述药物组合物制备为软膏剂的制备方法如下:按照相应重量份原料组分的配方,称取所述重量份配比的各原料组分,加水提取多次,合并三次提取液,过滤,将滤液浓缩至80℃下相对密度为1.10-1.30kg/m3的浸膏,加入乙醇,使其含醇量为40-70%,静置12-24小时,滤过,滤液浓缩至80℃时相对密度为1.10-1.25kg/m3的浸膏,干燥,粉碎,与适量的水溶性基质配合,搅拌均匀,即得本发明药物组合物的软膏剂。
7.基于权利要求1-4所述的任意一种治疗骨性关节炎的药物组合物的制备方法,其特征在于,将所述药物组合物制备为酊剂的制备方法如下:照相应重量份原料组分的配方,称取所述重量份配比的各原料组分,对称取的各原料组分进行浸渍提取多次,倾取上清液,压榨药渣,合并三次上清液和压榨液,过滤,浓缩至相当于药材总重量4~6倍,过滤,分装,密封,即得本发药物组合物的酊剂。
8.基于权利要求1-4所述的任意一种治疗骨性关节炎的药物组合物的制备方法,其特征在于,将所述药物组合物制备为洗剂的制备方法:照相应重量份原料组分的配方,称取所述重量份配比的各原料组分,加入相当于各原料组分总重量1~2倍的40%~60%的乙醇浸渍12~48小时,然后用40%~60%的乙醇以每分钟约占原料总重量0.2%~0.6%的速度进行渗漉,收集相当于各原料组分总重量5-10倍量的渗漉液,回收乙醇,减压浓缩至相当于各原料组分总重量的1~2倍,过滤,得到药液,该药液即为活性成分,在活性成分中加入甘油,即制成本发明药物组合物的洗剂。
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102579634A (zh) * | 2012-02-23 | 2012-07-18 | 熊桂华 | 治疗膝关节骨性关节炎的外用中药组合物 |
CN103230576A (zh) * | 2013-04-12 | 2013-08-07 | 李月权 | 一种治疗骨关节疾病的中药组方及其制备方法 |
CN103405582A (zh) * | 2013-08-07 | 2013-11-27 | 柳州市中医院 | 改善类风湿关节炎关节肿痛的中药组合物 |
CN106038723A (zh) * | 2016-06-28 | 2016-10-26 | 郑胜 | 一种治疗骨性膝关节炎的中药凝胶膏及其制备方法 |
-
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102579634A (zh) * | 2012-02-23 | 2012-07-18 | 熊桂华 | 治疗膝关节骨性关节炎的外用中药组合物 |
CN103230576A (zh) * | 2013-04-12 | 2013-08-07 | 李月权 | 一种治疗骨关节疾病的中药组方及其制备方法 |
CN103405582A (zh) * | 2013-08-07 | 2013-11-27 | 柳州市中医院 | 改善类风湿关节炎关节肿痛的中药组合物 |
CN106038723A (zh) * | 2016-06-28 | 2016-10-26 | 郑胜 | 一种治疗骨性膝关节炎的中药凝胶膏及其制备方法 |
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