CN1129137A - Chinese ready-made medicine for external use for prevention and treatment of venereal disease - Google Patents

Abstract

The Chinese propretary is prepared from golden cypress, Huang cen, rheum officinale, scorpio and talcum etc. by using advanced technology to be made into spray or lotion. It has the functions of relieving internal heat of fever, anti-bacterial, diminishing inflammation, and diuresis etc. It is indicated effectively for treatment and prevention of various venereal disease, trichomoniasis vaginal trichomoniasis, urethritis and vaginitis, otherwise it can be used for the sterilizing of humanbody and external environment.

Description

A kind of external Chinese patent medicine of preventing and treating sexually transmitted disease (STD)

The present invention relates to a sharp external medical health care drug, particularly prevent and treat a kind of external medicinal herb spray or the washing liquid of sexually transmitted disease (STD).

At present, be on the rise based on the harm of the sexually transmitted disease (STD) of gonorrhea in open coastal city.In the infectious disease of 24 kinds of statutory reports, the incidence of Gonorrhea in Guangzhou, Shenzhen, Zhuhai has been occupied the 2nd, and Guangdong Province's incidence of Gonorrhea has occupied the 3rd, and Guizhou Province's incidence of Gonorrhea in 1991 has been listed as the 6th, and epidemic situation 30 provinces, cities and autonomous regions that affected the whole country.The sickness rate that it is worth noting child's gonorrhea is also rising, and this causes owing to the gonococcal external environment media of infant contact stain infects.Effectively prevent and treat the propagation of gonorrhea, strengthen self health care, strict sterilization management public place facility is imperative.Although, medicine such as epirubicin, norfloxacin, cephalosporin and other import drugs of existing at present treatment sexually transmitted disease (STD), because of it not only costs an arm and a leg, and to part patient weak curative effect and the big side effect of existence.

The present invention is exactly a kind of external used medicine of preventing and treating gonorrhea that has no side effect and have efficient sterilizing of exploitation, and not only be used for human body and can effectively prevent and treat gonorrhea, trichomonas vaginitis, vaginitis, urethritis, but and to be used for the external environment disinfection pollution-free.

The present invention also provides a kind of preparation method of preventing and treating sexually transmitted disease (STD) external Chinese patent medicine.

External used medicine of the present invention is to have selected for use natural Chinese medicine to make raw material, extracts dosage forms such as making advanced spray or lotion through the processing of science.

Is the dialectical of main sexually transmitted disease according to traditional traditional Chinese medical science to gonorrhea, thinks that this disease shows as that damp-heat in lower-JIAO is sick waits more, pents up the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels so urethral orifice redness, pyorrhea, purulent secretion and leucorrhoea grow in quantity occur because of pyretic toxicity, cervix uteri redness, the rotten to the corn tenderness; The humidity hysteresis bladder, stranguria with turbid discharge takes place in the gasification imbalance, disturbance in water passage, thus urine causalgia, urgent micturition appear, frequent micturition, even hematuria appears.Thereby take heat-clearing and toxic substances removing, the method for treatment of relieving stranguria by diuresis is selected the specially clear damp-heat in lower-JIAO of Cortex Phellodendri for use, the removing water retention by purgation detoxifcation, ginseng is with Radix Scutellariae, and it is principal agent that Radix Et Rhizoma Rhei is strengthened the heat clearing and damp drying effect, is aided with Herba Artemisiae Scopariae, Herba Hedyotidis Diffusae, the Fructus Kochiae, Talcum, Herba Scutellariae Barbatae, the pain relieving of Medulla Tetrapanacis clearing away heat-damp and promoting diuresis inducing diuresis for treating stranguria syndrome, control the inferior burnt as power, turbid heavy not heavy, Gu Zuo is with Radix Bupleuri, Radix Isatidis, Fructus Gardeniae, the Radix Arnebiae (Radix Lithospermi) heat-clearing and toxic substances removing is separated the pus detumescence, Herba Houttuyniae, Fructus Forsythiae, the Scorpio detoxicating and resolving stagnation of pathogens is because of the easy dryness-transformation impairment of YIN of the product of bitter cold, so with the Radix Rehmanniae, Rhizoma Anemarrhenae clearing away heat and promoting production of body fluid hemostasis, with Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription relieving spasm to stop pain for making.

The above-mentioned natural Chinese medicine village that selects for use must meet that " quality standard of contained relative medicine in the Chinese pharmacopoeia nineteen ninety version (an one) is (referring to this book the 277th, 273,15,172,203,306,86,215,22,48,118,190,193,257,143,270,99,312,100,184,71 pages).

The raw material consumption of external medicinal drug of the present invention is (by weight):

7 parts of 8 parts of Radix Et Rhizoma Rhei of 10 parts of Radix Scutellariaes of Cortex Phellodendri

4 parts of Radix Isatidis 6 portions of Radix Arnebiae (Radix Lithospermi)s of 2 portions of Fructus Gardeniaes (root)

2 parts of 8 portions of Scorpios of 8 portions of Herba Artemisiae Scopariaes of Herba Scutellariae Barbatae

6 parts of 4 parts of Fructus Forsythiaes of 8 parts of Radix Bupleuri of Flos Lonicerae

6 parts in 3 parts of Talcums of 8 portions of Medulla Tetrapanaciss of Herba Houttuyniae

4 parts in 8 portions of Radix Glycyrrhizaes of 4 parts of Rhizoma Anemarrhenaes of the Fructus Kochiae

10 parts of 10 parts of Herba Hedyotidis Diffusaes of Radix Rehmanniae

External used medicine of the present invention is mainly prepared by the following step:

A, choose Chinese crude drug by above-mentioned raw materials and consumption thereof;

B, be ground into coarse powder, 80% concentration that adds raw material weight is 60% ethanol, ultrasonic extraction 2-4 hours;

C, the ethanol extract of gained in the step (B) packed into left standstill 2 days in the hermetic container, precipitation is separated out, filter;

D, 20% concentration that adds raw material weight in resulting filtrate are 60% ethanol.

External used medicine of the present invention can be made into various dosage forms, as spray, washing liquid etc.When the preparation spray, add essence after in above-mentioned steps (C), staticly settling, propellant canned resulting ethanol extract in the step (D) and that filling is commonly used gets final product.When making washing liquid, add Fructus Gleditsia liquid and essence after in above-mentioned steps (C), staticly settling, ethanol extract is canned gets final product resultant in the step (D) at last.

According to the modern pharmacology analysis, the selected most of flavour of a drug of external used medicine of the present invention have the broad-spectrum antiseptic function, and are especially obvious to the Gram-negative coccus effect, and collaborative compatibility removing damp-heat of many medicines and antiphlogistic antibacterial effect are more outstanding.Clinical laboratory of the attached institute of honor justice medical college Bacteriology Room is measured with the sensitivity of external used medicine subtend kind antibacterial of the present invention, and method and result are as follows:

Sample: 30 milliliters of external used medicines of the present invention (water decoction).

Bacterial strain: strain separated from clinical samples

Method: adopt the borehole method to carry out, 50 milliliters in the former grain of Chinese herbs decoction is injected in every hole, 36 ℃ of 24 hours measurement inhibition zone diameters.(gonorrhea adopts the chocolate candle jar method to carry out with coccus).

The result is as shown in table 1, and external used medicine of the present invention is especially to gonorrhea diplococcus, and the colon bacillus inhibitory action is stronger.

Table 1:

Bacterial strain	Inferior number of experiment	Inhibition zone diameter (millimeter)
						?(1)	(2)	?(3)	??(4)
		Pseudomonas aeruginosa salmonella typhi shigella dysenteriae ETEC staphylococcus aureus diplococcus Candida albicans	(1)(2) (1)(2) (1) (1)(2)(3) (1)(2) (1)(2)(3)(4) (1)	Do not have 25 21 16 and do not have 22 nothings	20 22 do not have 15					?18 ?18	??20

In addition, medicine of the present invention has also been carried out acute toxicity testing, skin irritation test, and skin hypersensitive test, the result shows external used medicine of the present invention non-stimulated and anaphylaxis to skin, the reaction of acute toxicity testing no abnormality seen, dosis tolerata is 65g/kg.From 1988 with cause Zunyi Medical College, Zun Yi national folk institute of Pharmaceutical Research and Army Hospital are used for clinical, in 304 routine gonorrhea patients' clinical observation treatment, average cure rate is 89.80%, total effective rate reaches 100%.(seeing the report of scientific research office of Zunyi Medical College).

The preparation of embodiment 1 aerosol for external use

(A) raw material and consumption thereof are chosen Chinese crude drug:

Cortex Phellodendri 50 gram Radix Scutellariaes 40 gram Radix Et Rhizoma Rhei 35 gram Radix Isatidiss 10 grams

Fructus Gardeniae 30 gram Radix Arnebiae (Radix Lithospermi)s (root) 20 gram Herba Scutellariae Barbataes 40 gram Herba Artemisiae Scopariaes 40 grams

Radix Bupleuri 20 gram Scorpios 10 gram Medulla Tetrapanaciss 15 gram Flos Loniceraes 40 grams

The Talcum 30 gram Fructus Forsythiaes 30 gram Rhizoma Anemarrhenaes 40 gram Herba Houttuyniae 40 grams

The Radix Glycyrrhizae 20 gram Radix Rehmanniae 50 gram Herba Hedyotidis Diffusaes 50 gram Fructus Kochiae 20 grams

Add up to: 630 grams

(B) pulverizing is coarse powder, adds 60% ethanol, 506 grams, ultrasonic extraction 3 hours

(C) the resulting extracting solution of step (B) is packed into left standstill 2 days under the hermetic container room temperature, precipitation is separated out, add essence, filter;

(D) in resulting filtrate, add 60% ethanol, 126 grams;

(E) canned resulting extracting solution in the step (D), fill propellant.

Claims (2)

1, a kind of external Chinese patent medicine of preventing and treating sexually transmitted disease (STD) is characterized in that it has selected for use the following traditional Chinese medicines material to form as feedstock production: (by weight)

7 parts of 8 parts of Radix Et Rhizoma Rhei of 10 parts of Radix Scutellariaes of Cortex Phellodendri

4 parts of Radix Isatidis 6 portions of Radix Arnebiae (Radix Lithospermi)s of 2 portions of Fructus Gardeniaes (root)

2 parts of 8 portions of Scorpios of 8 portions of Herba Artemisiae Scopariaes of Herba Scutellariae Barbatae

6 parts of 4 parts of Fructus Forsythiaes of 8 parts of Radix Bupleuri of Flos Lonicerae

6 parts in 3 parts of Talcums of 8 portions of Medulla Tetrapanaciss of Herba Houttuyniae

4 parts in 8 portions of Radix Glycyrrhizaes of 4 parts of Rhizoma Anemarrhenaes of the Fructus Kochiae

10 parts of 10 parts of Herba Hedyotidis Diffusaes of Radix Rehmanniae

2, a kind of preparation method of preventing and treating the external medicinal liquid of sexually transmitted disease (STD) is characterized in that it contains the following step:

A, choose Chinese crude drug by raw material described in the claim 1 and consumption thereof;

B, be ground into coarse powder, and 80% concentration that adds raw material weight is 60% ethanol, ultrasonic extraction 2-4 hour;

C, the ethanol extract of gained in the step (B) packed into left standstill 2 days in the hermetic container, precipitation is separated out, filter;

D, 20% concentration that adds raw material weight in resulting filtrate are 60% ethanol.