CN112903078B - Laboratory mouse data acquisition device and acquisition method - Google Patents
Laboratory mouse data acquisition device and acquisition method Download PDFInfo
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- CN112903078B CN112903078B CN202110078919.2A CN202110078919A CN112903078B CN 112903078 B CN112903078 B CN 112903078B CN 202110078919 A CN202110078919 A CN 202110078919A CN 112903078 B CN112903078 B CN 112903078B
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- 238000000034 method Methods 0.000 title claims abstract description 21
- 238000005303 weighing Methods 0.000 claims abstract description 147
- 230000007246 mechanism Effects 0.000 claims abstract description 43
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 230000035622 drinking Effects 0.000 claims abstract description 25
- 239000003651 drinking water Substances 0.000 claims abstract description 15
- 235000020188 drinking water Nutrition 0.000 claims abstract description 15
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 64
- 230000037213 diet Effects 0.000 claims description 10
- 235000005911 diet Nutrition 0.000 claims description 10
- 241000699670 Mus sp. Species 0.000 claims description 8
- 238000013480 data collection Methods 0.000 claims description 6
- 230000005611 electricity Effects 0.000 claims description 2
- 235000012631 food intake Nutrition 0.000 abstract description 13
- 238000002474 experimental method Methods 0.000 abstract description 10
- 241001465754 Metazoa Species 0.000 description 7
- 241000282414 Homo sapiens Species 0.000 description 6
- 238000010171 animal model Methods 0.000 description 6
- 238000011161 development Methods 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 241000700159 Rattus Species 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 230000004584 weight gain Effects 0.000 description 3
- 235000019786 weight gain Nutrition 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 208000031873 Animal Disease Models Diseases 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 101100460719 Mus musculus Noto gene Proteins 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000011558 animal model by disease Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01G—WEIGHING
- G01G19/00—Weighing apparatus or methods adapted for special purposes not provided for in the preceding groups
- G01G19/52—Weighing apparatus combined with other objects, e.g. furniture
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K29/00—Other apparatus for animal husbandry
- A01K29/005—Monitoring or measuring activity, e.g. detecting heat or mating
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/04—Programme control other than numerical control, i.e. in sequence controllers or logic controllers
- G05B19/042—Programme control other than numerical control, i.e. in sequence controllers or logic controllers using digital processors
- G05B19/0428—Safety, monitoring
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
- G06K7/00—Methods or arrangements for sensing record carriers, e.g. for reading patterns
- G06K7/10—Methods or arrangements for sensing record carriers, e.g. for reading patterns by electromagnetic radiation, e.g. optical sensing; by corpuscular radiation
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B2219/00—Program-control systems
- G05B2219/20—Pc systems
- G05B2219/26—Pc applications
- G05B2219/2612—Data acquisition interface
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Abstract
The invention belongs to the technical field of biological experiments, and particularly relates to a laboratory mouse data acquisition device and a laboratory mouse data acquisition method. The acquisition device comprises a data acquisition box, wherein an opening is formed in the data acquisition box, and a door lock mechanism is arranged at the opening; a non-weighing platform, a weighing platform and a data acquisition platform are arranged on the bottom surface in the data acquisition box, the non-weighing platform is arranged close to the door lock mechanism, the data acquisition platform is arranged far away from the door lock mechanism, and the weighing platform is arranged between the non-weighing platform and the data acquisition platform; the bottom of the weighing platform is provided with a first weighing sensor, the bottom of the data acquisition platform is provided with a second weighing sensor, and one side of the data acquisition box, which is opposite to the door lock mechanism, is provided with an RFID sensor; the MCU master controller is electrically connected with the first weighing sensor and the door lock mechanism. The collecting device can realize the automatic accurate collection of the weight, the food consumption, the times of eating, the water drinking amount and the times of drinking water of a single experimental mouse.
Description
Technical Field
The invention belongs to the technical field of biological experiments, and particularly relates to a laboratory mouse data acquisition device and a laboratory mouse data acquisition method.
Background
Animal experiments refer to scientific research using animals in laboratories to gain new knowledge about biology, medicine, etc. or to solve specific problems. Animal experiments must be carried out by trained personnel with academic or professional skills or under the guidance of the personnel, and the final aim of scientific development of experimental animals is to develop and guide human beings by researching the life phenomena of the animals, explore the mystery of human life, control human diseases and aging and prolong the life of the human beings. With the rapid development of medical science and bioscience, it is recognized that the public hazard problem not only becomes a serious social problem of food, population, the elderly, etc., but also relates to the survival problem of animals living on the earth, such as industrial hazard, food hazard, drug toxicity, etc., which directly affect human health, and the research on the problems is finally inevitably solved through animal experiments (including the development of animal disease models, etc.). Therefore, the importance of experimental animal science, particularly experimental animals, is more and more recognized and has been considered as the pillar for human beings to pursue happy life, so experimental animal science is also called life science; therefore, advanced countries pay high attention to the development of experimental animal science, the input economic materials and technical force can be almost compatible with the development of atomic energy science, and the important significance of the experimental animal science can be known.
In biological research, various experiments are often required for small animals, and in some experiments, the food consumption, the frequency of eating, the water drinking and the frequency of drinking of laboratory mice are required to be measured. In the prior art, the measurement method adopted when measuring the food intake and the water intake of the laboratory mouse is as follows: the feed and water weighed by an electronic scale and a measuring cylinder in advance are put into a cage with a laboratory mouse, and after a certain time interval, the feed and the rest water are taken out for weighing and measuring.
When the method is used for collecting the data of the food consumption, the food frequency, the water drinking amount and the water drinking frequency of a single experimental mouse, the experimental mouse needs to be taken out for measurement after eating to obtain the food consumption and the food frequency, and the experimental mouse needs to be taken out for measurement after drinking to obtain the food consumption and the water drinking frequency, so that repeated experiments are needed; moreover, data of a plurality of experimental mice are required to be collected, and the experiment frequency is increased.
When the method is used for collecting the data of the food consumption, the food frequency, the water drinking amount and the water drinking frequency of a plurality of experimental rats, because the experimental rats have different food and water drinking frequencies and different eating amounts, the experimental data collection is very complicated and the data is not accurate.
In conclusion, the existing method for collecting the data of the food consumption, the food frequency, the water drinking amount and the water drinking frequency of the laboratory mouse not only needs manual operation, but also needs a great deal of time, so that the problem of low accuracy exists in the data which is difficult and laborious to collect.
Disclosure of Invention
The invention provides a laboratory mouse data acquisition device and a laboratory mouse data acquisition method. The collecting device can realize the automatic accurate collection of the weight, the food consumption, the times of eating, the water drinking amount and the time of drinking of a single experimental mouse.
The invention is realized by the following technical scheme:
the invention provides a laboratory mouse data acquisition device which comprises a data acquisition box, a non-weighing platform, a first weighing sensor, a second data acquisition platform, a second weighing sensor, an MCU master controller, a door lock mechanism and an RFID sensor, wherein the data acquisition box is connected with the non-weighing platform through a first cable;
the data acquisition box is provided with an opening, and the opening is provided with a door lock mechanism; a non-weighing platform, a weighing platform and a data acquisition platform are arranged on the bottom surface in the data acquisition box, the non-weighing platform is arranged close to the door lock mechanism, the data acquisition platform is arranged far away from the door lock mechanism, and the weighing platform is arranged between the non-weighing platform and the data acquisition platform;
the first weighing sensor is arranged at the bottom of the weighing platform and used for measuring the weight of the weighing platform and the weight of the laboratory mouse on the weighing platform and transmitting the weight to the MCU master controller; the bottom of the data acquisition platform is provided with a second weighing sensor, and the second weighing sensor is used for measuring the weight of the laboratory mouse on the data acquisition platform and transmitting the weight to the MCU main controller;
an RFID sensor is arranged on one side, opposite to the door lock mechanism, in the data acquisition box;
and the MCU master controller is electrically connected with the first weighing sensor and the door lock mechanism.
Further, the elevations of the non-weighing platform, the weighing platform and the data acquisition platform are the same.
Further, the sum of the surface area of the non-weighing platform, the surface area of the weighing platform and the surface area of the data acquisition platform is equal to the surface area of the bottom surface of the data acquisition box.
Furthermore, the weighing platform is connected with the data acquisition box through support columns, the number of the support columns is two, and the first weighing sensor is connected between the two support columns.
Furthermore, the data acquisition platform is connected with the data acquisition box through two support columns, and the two support columns are connected with the second weighing sensor.
Furthermore, the number of the data acquisition stations is two, and the two data acquisition stations are respectively a drinking water data acquisition station and a diet data acquisition station.
Further, door lock mechanism includes one-way revolving door and telescopic switch, telescopic switch and one-way revolving door set up respectively at the relative both ends of opening, one-way revolving door and telescopic switch cooperation work, the MCU master controller is connected to telescopic switch electricity.
The invention also provides a laboratory mouse data acquisition method, which comprises the data acquisition device, and comprises the following steps:
a: attaching RFID electronic tags to all the experimental mice;
b: a single experimental mouse enters the weighing platform through an opening of the data acquisition box, the first weighing sensor transmits weight information to the MCU main controller, and the MCU main controller controls the door lock mechanism to be closed;
c: the RFID sensor identifies an RFID electronic tag carried by the laboratory mouse entering the data acquisition box and transmits the RFID electronic tag to the computer;
d: the laboratory mouse enters a data acquisition table, and the weighing sensor II obtains weight information of the laboratory mouse before eating or drinking and transmits the weight information to the computer;
e: the weight of the experimental mouse on the data acquisition table changes after eating or drinking water, and the weighing sensor II transmits weight information to the computer;
f: after eating or drinking water of the laboratory mouse is finished, the laboratory mouse enters the weighing platform, the first weighing sensor transmits weight information to the MCU main controller, and the MCU main controller controls the door lock mechanism to be opened;
g: the experimental mouse in the data acquisition device is discharged out of the data acquisition box;
h: the above B to G were repeated.
The MCU master controller controls the conditions that the opening and closing of the door lock mechanism meet to be as follows:
closing the door lock mechanism: the average weight of the weighing platform in the first 3 seconds is within the range of [ M +0.5K, M +1.5K ], and the average weight of the weighing platform in the current 1 second is also within the range of [ M +0.5K, M +1.5K ];
the door lock mechanism is opened: the average weight of the weighing platform in the first 3 seconds is in the range of [ M-0.1K, M +0.1K ];
or the average weight of the weighing platform in the first 3 seconds is in the range of [ M-0.1K, M +0.1K ], and the average weight of the weighing platform in the current 1 second is also in the range of [ M-0.1K, M +0.1K ];
wherein M is the weight of the weighing platform;
k is the average weight K of the experimental rats.
By adopting the technical scheme, the invention has the following advantages:
1. the collecting device can realize the automatic accurate collection of the weight, the food consumption, the times of eating, the water drinking amount and the time of drinking of a single experimental mouse.
2. The acquisition device can control a single experimental mouse to enter the data acquisition box, realizes the acquisition of the food consumption, the food frequency, the water intake and the water drinking frequency of the single experimental mouse, does not need manual control, and has high accuracy of acquired data.
3. According to the invention, the experimental mice are identified through the RFID sensor, the data of the food consumption, the food frequency, the water drinking amount and the water drinking frequency of each experimental mouse can be accurately collected, and the data of each experimental mouse can be accurately collected. The invention can collect the food consumption, the times of eating, the water drinking and the times of drinking of the laboratory mice and can also collect the weight of each laboratory mouse.
4. The invention transmits the weight information to the MCU master controller through the weighing sensor connected with the weighing platform, and the MCU master controller controls the opening and closing of the door lock mechanism to realize the entrance and exit of a single experimental mouse.
5. The invention can realize all-weather 24-hour automatic acquisition.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments of the present invention or in the description of the prior art will be briefly described below, and it is obvious that the drawings described below are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic view of the structure of the present invention;
FIG. 2 is a connection diagram of the weighing platform, the support and the first weighing sensor of the invention;
FIG. 3 is a connection diagram of a data acquisition platform, a support column and a second weighing sensor;
in the drawings: 1. the device comprises a data acquisition box, 2, a non-weighing platform, 3, a weighing platform, 4, weighing sensors I and 5, a data acquisition platform, 51, a drinking water data acquisition platform, 52 and a diet data acquisition platform; 6. weighing sensor two, 7, MCU master controller, 8, lock mechanism, 81, one-way revolving door, 811, rotatory mouth, 82, telescopic switch, 9, RFID inductor, 10, support column, 11, laboratory mouse, 12, RFID electronic tags.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the drawings are illustrative and intended to be illustrative of the invention and are not to be construed as limiting the invention.
In the description of the present invention, it should be noted that when an element is referred to as being "fixed" or "disposed" to another element, it can be directly on the other element or be indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or be indirectly connected to the other element.
It will be understood that the terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like, as used herein, refer to an orientation or positional relationship indicated in the drawings that is solely for the purpose of facilitating the description and simplifying the description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and is therefore not to be construed as limiting the invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or to implicitly indicate the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
The specific meanings of the above terms in the present invention can be understood according to specific situations by those of ordinary skill in the art.
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to the accompanying drawings and embodiments.
As shown in FIG. 1, the invention provides a laboratory mouse data acquisition device on one hand, which comprises a data acquisition box 1, a non-weighing platform 2, a weighing platform 3, a first weighing sensor 4, a data acquisition platform 5, a second weighing sensor 6, an MCU master controller 7, a door lock mechanism 8 and an RFID sensor 9;
an opening is formed in the data acquisition box 1, and a door lock mechanism 8 is arranged at the opening; a non-weighing platform 2, a weighing platform 3 and a data acquisition platform 5 are arranged on the bottom surface in the data acquisition box 1, the non-weighing platform 2 is arranged close to a door lock mechanism 8, the data acquisition platform 5 is arranged far away from the door lock mechanism 8, and the weighing platform 3 is arranged between the non-weighing platform 2 and the data acquisition platform 5;
the bottom of the weighing platform 3 is provided with a first weighing sensor 4, and the first weighing sensor 4 is used for measuring the weights of the weighing platform 3 and the laboratory mouse 11 on the weighing platform 3 and transmitting the weights to the MCU master controller 7; the bottom of the data acquisition platform 5 is provided with a second weighing sensor 6, and the second weighing sensor 6 is used for measuring the weight of the laboratory mouse 11 on the data acquisition platform 5 and transmitting the weight to the MCU master controller 7;
an RFID sensor 9 is arranged on one side, opposite to the door lock mechanism 8, in the data acquisition box 1;
and the MCU main controller 7 is electrically connected with the first weighing sensor 4 and the door lock mechanism 8.
It should be noted that the MCU master 7, the RFID sensor, the first load cell 4, and the second load cell 6 are all existing products, and those skilled in the art can directly select and use the existing products.
Further, the non-weighing station 2, the weighing station 3 and the data acquisition station 5 have the same elevation. The non-weighing platform 2, the weighing platform 3 and the data acquisition platform 5 form a platform together, and the non-weighing platform 2, the weighing platform 3 and the data acquisition platform 5 are not connected; the non-weighing platform 2, the weighing platform 3 and the data acquisition platform 5 are not affected by each other and act independently; that is, when the laboratory mouse was on non-weighing platform 2, weighing platform 3 and data acquisition platform 5 can not have weight gain, and when the laboratory mouse was on weighing platform 3, only weighing platform 3's weight gain, and when the laboratory mouse was on data acquisition platform 5, only data acquisition platform 5's weight gain. The non-weighing platform 2, the weighing platform 3 and the data acquisition platform 5 with the same elevation are convenient for the laboratory mouse 11 to move.
Of course, the non-weighing station 2, the weighing station 3 and the data collecting station 5 may also be arranged at different elevations, for example, the data collecting station 5 is arranged above the weighing station 3.
Further, the sum of the surface area of the non-weighing table 2, the surface area of the weighing table 3 and the surface area of the data collection table 5 is equal to the surface area of the bottom surface of the data collection box 1.
The sum of the surface area of the non-weighing platform 2, the surface area of the weighing platform 3 and the surface area of the data acquisition platform 5 is equal to the surface area of the bottom surface of the data acquisition box 1. The non-weighing platform 2, the weighing platform 3 and the data acquisition platform 5 can be prevented from being matched with the platform edge formed to form a gap with the data acquisition box, and the transverse space of the data acquisition box can be utilized to the maximum extent.
Furthermore, the weighing platform 3 is connected with the data acquisition box 1 through two support columns 10, and the weighing sensors 4 are connected between the two support columns 10.
Further, the data acquisition platform 5 is connected with the data acquisition box 1 through support columns 10, two support columns 10 are arranged, and the two weighing sensors 6 are connected between the two support columns 10.
It should be noted that, as shown in fig. 2 and 3, the connection structures of the data collection platform 5 and the weighing platform 3 and the data collection box 1 are similar, and the working principle is the same, that is, the weight is sensed and transmitted by the weighing sensor.
Further, two data acquisition stations 5 are provided, and the two data acquisition stations 5 are a drinking water data acquisition station 51 and a diet data acquisition station 52 respectively. Enabling more accurate data to be collected.
In the experiment, food and water are suspended in the data acquisition box, and the food is positioned above the diet data acquisition table 52, so that the laboratory mouse can realize diet when on the diet data acquisition table 52; the water level is above the water drinking data acquisition platform 51, so that the laboratory mouse can drink water only when on the water drinking data acquisition platform 51.
Further, the door lock mechanism 8 comprises a one-way rotating door 81 and a telescopic switch 82, the telescopic switch 82 and the one-way rotating door 81 are respectively arranged at two opposite ends of the opening, the one-way rotating door 81 and the telescopic switch 82 work in a matching mode, and the telescopic switch 82 is electrically connected with the MCU master controller 7.
It should be noted that, the structure of the unidirectional rotation door 81 is shown in fig. 1, only the structure of the unidirectional rotation door 81 is the prior art, and the present invention can be manufactured according to the specific size; the one-way rotary door 81 can accommodate only one laboratory mouse per one rotary port 811. The telescopic switch 82 may be provided as a telescopic device, and those skilled in the art may select a telescopic device from many available devices, and select a device to use according to actual conditions. The specific working principle is as follows: the retractable switch 82 extends into the rotation opening 811 of the unidirectional rotation door 81 and is locked so that the unidirectional rotation door 81 cannot rotate to achieve locking.
The invention also provides a laboratory mouse data acquisition method, which comprises the data acquisition device, and comprises the following steps:
a: attaching RFID electronic tags 12 to all the experimental mice 11;
b: a single experimental mouse 11 enters the weighing platform 3 through an opening of the data acquisition box 1, the weighing inductor I4 transmits weight information to the MCU main controller 7, and the MCU main controller 7 controls the door lock mechanism 8 to be closed;
c: the RFID sensor 9 identifies an RFID electronic tag 12 carried by a laboratory mouse 11 entering the data acquisition box 1 and transmits the RFID electronic tag to a computer;
d: the laboratory mouse 11 enters the data acquisition platform 5, and the second weighing sensor 6 obtains weight information of the laboratory mouse 11 before eating or drinking water and transmits the weight information to the computer;
e: the weight of the experimental mouse 11 on the data acquisition platform 5 changes after eating or drinking water, and the second weighing sensor 6 transmits weight information to the computer;
f: after eating or drinking water of the laboratory mouse 11 is finished, the laboratory mouse enters the weighing platform 3, the weighing sensor I4 transmits weight information to the MCU main controller 7, and the MCU main controller 7 controls the door lock mechanism 8 to be opened;
g: the laboratory mouse 11 in the data acquisition device is discharged out of the data acquisition box 1;
h: the above B to G were repeated.
The MCU master controller 7 controls the conditions met by the opening and closing of the door lock mechanism 8 to be as follows:
the door lock mechanism 8 is closed: the average weight of the weighing station 3 in the first 3 seconds is in the range of [ M +0.5K, M +1.5K ], and the average weight of the weighing station 3 in the current 1 second is also in the range of [ M +0.5K, M +1.5K ]
The door lock mechanism 8 is opened: the average weight of the weighing platform 3 in the first 3 seconds is in the range of [ M-0.1K, M +0.1K ];
or the average weight of the weighing platform 3 in the first 3 seconds is in the range of [ M-0.1K, M +0.1K ], and the average weight of the weighing platform 3 in the current 1 second is also in the range of [ M-0.1K, M +0.1K ];
wherein M is the weight of the weighing station 3;
k is the average weight K of the laboratory mice 11.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (8)
1. A laboratory mouse data acquisition method is characterized in that: the system comprises a data acquisition box (1), a non-weighing platform (2), a weighing platform (3), a first weighing sensor (4), a data acquisition platform (5), a second weighing sensor (6), an MCU master controller (7), a door lock mechanism (8) and an RFID sensor (9); an opening is formed in the data acquisition box (1), and a door lock mechanism (8) is arranged at the opening; a non-weighing platform (2), a weighing platform (3) and a data acquisition platform (5) are arranged on the bottom surface in the data acquisition box (1), the non-weighing platform (2) is arranged close to the door lock mechanism (8), the data acquisition platform (5) is arranged far away from the door lock mechanism (8), and the weighing platform (3) is arranged between the non-weighing platform (2) and the data acquisition platform (5); the bottom of the weighing platform (3) is provided with a first weighing sensor (4), and the first weighing sensor (4) is used for measuring the weights of the weighing platform (3) and the laboratory mouse (11) on the weighing platform (3) and transmitting the weights to the MCU master controller (7); the bottom of the data acquisition platform (5) is provided with a second weighing sensor (6), and the second weighing sensor (6) is used for measuring the weight of the laboratory mouse (11) on the data acquisition platform (5) and transmitting the weight to the MCU master controller (7); two data acquisition platforms (5) are arranged, and the two data acquisition platforms (5) are respectively a drinking water data acquisition platform (51) and a diet data acquisition platform (52); food and water are suspended in the data acquisition box, and the food is positioned above the diet data acquisition platform (52), so that the laboratory mouse can eat on the diet data acquisition platform (52); the water level is above the drinking water data acquisition platform (51), so that the laboratory mouse can drink water only when on the drinking water data acquisition platform (51); an RFID sensor (9) is arranged on one side, opposite to the door lock mechanism (8), in the data acquisition box (1); the MCU main controller (7) is electrically connected with the first weighing sensor (4) and the door lock mechanism (8);
the acquisition method comprises the following steps:
a: attaching RFID electronic tags (12) to all the experimental mice (11);
b: a single experimental mouse (11) enters the weighing platform (3) through an opening of the data acquisition box (1), the weighing sensor I (4) transmits weight information to the MCU master controller (7), and the MCU master controller (7) controls the door lock mechanism (8) to be closed;
c: the RFID sensor (9) identifies an RFID electronic tag (12) carried by a laboratory mouse (11) entering the data acquisition box (1) and transmits the RFID electronic tag to the computer;
d: the laboratory mouse (11) enters the data acquisition platform (5), and the second weighing sensor (6) obtains weight information of the laboratory mouse (11) before eating or drinking water and transmits the weight information to the computer;
e: the weight of the laboratory mouse (11) on the data acquisition platform (5) changes after eating or drinking water, and the second weighing sensor (6) transmits weight information to the computer;
f: after eating or drinking of the laboratory mouse (11) is finished, the laboratory mouse enters the weighing platform (3), the first weighing sensor (4) transmits weight information to the MCU master controller (7), and the MCU master controller (7) controls the door lock mechanism (8) to be opened;
g: the laboratory mouse (11) in the data acquisition device is discharged out of the data acquisition box (1);
h: the above B to G were repeated.
2. The method of claim 1, wherein the data acquisition is performed by: the elevations of the non-weighing platform (2), the weighing platform (3) and the data acquisition platform (5) are the same.
3. A method as claimed in claim 1 or 2, wherein: the sum of the surface area of the non-weighing platform (2), the surface area of the weighing platform (3) and the surface area of the data acquisition platform (5) is equal to the surface area of the bottom surface of the data acquisition box (1).
4. A method as claimed in claim 3, wherein the data acquisition method comprises: the weighing platform (3) is connected with the data acquisition box (1) through support columns (10), the number of the support columns (10) is two, and the two support columns (10) are connected with the weighing sensor I (4).
5. A method as claimed in claim 3, wherein the data acquisition method comprises: the data acquisition platform (5) is connected with the data acquisition box (1) through support columns (10), the two support columns (10) are arranged, and the two weighing sensors (6) are connected between the two support columns (10).
6. The method of claim 5, wherein the data collection system comprises: the number of the data acquisition platforms (5) is two, and the two data acquisition platforms (5) are respectively a drinking water data acquisition platform (51) and a diet data acquisition platform (52).
7. The method of claim 1, wherein the data acquisition is performed by: door lock mechanism (8) are including one-way revolving door (81) and telescopic switch (82), telescopic switch (82) and one-way revolving door (81) set up respectively at the relative both ends of opening, one-way revolving door (81) and telescopic switch (82) cooperation work, MCU master controller (7) is connected to telescopic switch (82) electricity.
8. A method as claimed in claim 1, comprising the steps of: the MCU master controller (7) controls the conditions met by the opening and closing of the door lock mechanism (8) to be as follows: closing the door lock mechanism (8): the average weight of the weighing platform (3) in the first 3 seconds is in the range of [ M +0.5K, M +1.5K ], and the average weight of the weighing platform (3) in the current 1 second is also in the range of [ M +0.5K, M +1.5K ] and the door lock mechanism (8) is opened: the average weight of the weighing platform (3) in the first 3 seconds is within the range of [ M-0.1K, M +0.1K ]; or the average weight of the weighing platform (3) in the first 3 seconds is within the range of [ M-0.1K, M +0.1K ], and the average weight of the weighing platform (3) in the current 1 second is also within the range of [ M-0.1K, M +0.1K ]; wherein M is the weight of the weighing platform (3); k is the average weight K of the test mouse (11).
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