CN112891485B - 一种用于新冠肺炎治疗的中药组合物 - Google Patents
一种用于新冠肺炎治疗的中药组合物 Download PDFInfo
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Abstract
本发明公开了一种用于新冠肺炎治疗的中药组合物,包含以下重量份的组分:肉苁蓉10~30份,桂枝3~15份,党参9~30份,炙黄芪9~30份,炒白术6~30份,茯苓9~15份,焦神曲6~20份,焦麦芽9~20份,焦山楂9~20份,甘草1.5~9份,香橼6~18份,佛手6~18份。本发明的基础处方用药,取肉苁蓉、桂枝,辛润甘温,润燥助阳,温阳化气;党参、黄芪、甘草,甘温不燥,两补脾肺之气;白术、茯苓,甘淡平正,化除内湿;神曲、麦芽、山楂,消食开胃;香橼皮、佛手疏肝解郁;上述药物配伍起到了益气通阳、健脾和中的功效。
Description
技术领域
本发明涉及一种中药组合物,具体涉及一种用于新冠肺炎治疗的中药组合物。属于中药技术领域。
背景技术
在新冠肺炎的治疗过程中,新疆医科大学第六附属医院,第八附属医院按照国内多版抗疫指南进行临床诊治,但效果迟滞。因新疆地区地势气候及居民体质与内地存在明显差异,故患者多发焦虑且临床特征有所不同。在遵循三因制宜的原则上,结合新冠患者发病后偏阳虚阴盛、肝郁气滞的临床症状,我们遂拟定了温阳润燥、健脾和中的治法依据,开发了一种用于新冠肺炎治疗的中药组合物。在治疗新冠肺炎患者及复阳的新冠患者过程中,疗效显著,实现了快速转阴、抑制复阳、有效治愈的成果。
发明内容
本发明的目的是为克服上述现有技术的不足,提供一种用于新冠肺炎治疗的中药组合物。
为实现上述目的,本发明采用下述技术方案:
一种用于新冠肺炎治疗的中药组合物,包含以下重量份的组分:肉苁蓉10~30份,桂枝3~15份,党参9~30份,炙黄芪9~30份,炒白术6~30份,茯苓9~15份,焦神曲6~20份,焦麦芽9~20份,焦山楂9~20份,甘草1.5~9份,香橼6~18份,佛手6~ 18份。
优选的,包含以下重量份的组分:肉苁蓉10~20份,桂枝5~12份,党参9~20份,炙黄芪9~30份,炒白术6~30份,茯苓9~15份,焦神曲6~20份,焦麦芽9~20份,焦山楂9~20份,甘草1.5~9份,香橼6~18份,佛手6~18份。
优选的,还包含以下重量份的组分:藿香3~18份,佩兰3~18份,厚朴3~18份,草豆蔻3~18份,炒薏苡仁9~35份。
优选的,还包含以下重量份的组分:柴胡3~12份,郁金3~18份。
优选的,还包含以下重量份的组分:炒酸枣仁9~30份,磁石9~30份,龙骨15~45份,牡蛎9~45份。
优选的,还包含以下重量份的组分:柴胡3~12份,法半夏3~12份,黄芩3~18份,干姜3~9份。
一种用于新冠肺炎治疗的制剂,其有效成分为前述的中药组合物。
优选的,所述制剂形式为按照常规方法制备的汤剂、颗粒、胶囊或丸剂。
前述的中药组合物在制备新冠肺炎治疗药物中的应用。
本发明的有益效果:本发明以温阳润燥、健脾和中为据,将特定配方组成的肉苁蓉、桂枝、党参、炙黄芪、炒白术、茯苓、焦神曲、焦麦芽、焦山楂、甘草、香橼皮、佛手混合形成中药组合物,用于新冠肺炎治疗。本发明的基础处方用药,取肉苁蓉、桂枝,辛润甘温,润燥助阳,温阳化气;党参、黄芪、甘草,甘温不燥,两补脾肺之气;白术、茯苓,甘淡平正,化除内湿;神曲、麦芽、山楂,消食开胃;香橼皮、佛手疏肝解郁。上述药物配伍,起到了益气通阳、健脾和中的功效。
附图说明
图1是各组患者病毒核酸转阴时间的比较;
图2是各组患者治疗7天后病毒核酸转阴率的比较;
图3是治疗期间各组患者病毒核酸复阳率;
图4是各组间CT炎症缓解率的比较。
具体实施方式
下面结合附图和实施例对本发明进行进一步的阐述,应该说明的是,下述说明仅是为了解释本发明,并不对其内容进行限定。
本申请实施例提供了一种用于新冠肺炎治疗的中药组合物,包含以下重量份的组分:肉苁蓉10~30份,桂枝3~15份,党参9~30份,炙黄芪9~30份,炒白术6~30份,茯苓9~15份,焦神曲6~20份,焦麦芽9~20份,焦山楂9~20份,甘草1.5~9份,香橼6~18份,佛手6~18份。
本发明以温阳润燥、健脾和中为据,将特定配方组成的肉苁蓉、桂枝、党参、炙黄芪、炒白术、茯苓、焦神曲、焦麦芽、焦山楂、甘草、香橼皮、佛手混合形成中药组合物,用于新冠肺炎治疗。本发明的基础处方用药,取肉苁蓉、桂枝,辛润甘温,润燥助阳,温阳化气;党参、黄芪、甘草,甘温不燥,两补脾肺之气;白术、茯苓,甘淡平正,化除内湿;神曲、麦芽、山楂,消食开胃;香橼皮、佛手疏肝解郁。上述药物配伍,起到了益气通阳、健脾和中的功效。
本申请实施例的各组分的用量可以在合理范围内进行调整。
一些实施例中,肉苁蓉的用量可以是10~30份、10~25份、10~20等。桂枝用量可以是3~15份、3~12份或3~9份,党参9~30份、9~20份或9~10份,炙黄芪9~30份、9~20份或15~20份,炒白术6~30份、6~25份、6~20份或20~30份,茯苓9~15、9~12份或 9~10份,焦神曲6~20份、6~15份或6~10份,焦麦芽9~20、9~15份或9~12份,焦山楂9~20份、9~15份或9~12份,甘草1.5~9份或1.5~6份,香橼6~18份或8~15份,佛手6~18份或10~15份。上述任一组分的用量可以用于替代上述基础配方中的用量,各组分的用量也可以任意结合得到具体的配方。
本申请实施例中,以肉苁蓉,桂枝,党参,炙黄芪,炒白术,茯苓,焦神曲,焦麦芽,焦山楂,甘草,香橼,佛手构成的配方为治疗新冠肺炎的基础组方。在此基础上根据临床症状可以加减其它合理的组分。
示例性实施例中,藿香、佩兰、厚朴、草豆蔻、薏苡,起到芳香避秽、化湿清热效果;柴胡、郁金,枣仁、磁石、龙骨、牡蛎,增加疏肝解郁、镇逆宁心效果;柴胡、半夏、黄芩、干姜,起到和解少阳、调适枢机效果。
一些实施例中,本申请实施例的组合物还包含以下重量份的组分:藿香3~18份、5~ 15份或8~12份,佩兰3~18份、3~15份或5~10份,厚朴3~18份、3~15份或5~ 10份,草豆蔻3~18份、3~15份或5~10份,炒薏苡仁9~35份、10~30份或15~25 份。
一些实施例中,本申请实施例的组合物还包含以下重量份的组分:柴胡3~12份,3~ 9份或5~8份,郁金3~18份、5~15份或8~12份。
一些实施例中,本申请实施例的组合物还包含以下重量份的组分:炒酸枣仁9~30份, 10~30份或15~25份,磁石9~30份,10~30份或15~25份,龙骨9~45份、9~40份、 10~35份或20~30份,牡蛎9~45份、9~40份、10~35份或20~30份。
一些实施例中,本申请实施例的组合物还包含以下重量份的组分:柴胡3~12份、3~9份或3~6份,法半夏6~12份、3~9份或3~6份,黄芩3~18份、3~15份或3~10 份,干姜3~9份或3~6份。
一种用于新冠肺炎治疗的制剂,其有效成分为前述任一实施例的中药组合物。
优选的,所述制剂形式为按照常规方法制备的汤剂、颗粒、胶囊或丸剂。
前述的任一实施例中的药组合物在制备新冠肺炎治疗药物中的应用。
一、具体实施例
实施例1:
一种用于新冠肺炎治疗的中药组合物,每剂包含以下组分:肉苁蓉10克,桂枝15克,党参9克,炙黄芪30克,炒白术6克,茯苓15克,焦神曲9克,焦麦芽9克,焦山楂9 克,甘草9克,香橼6克,佛手6克。
实施例2:
一种用于新冠肺炎治疗的中药组合物,每剂包含以下组分:肉苁蓉30克,桂枝6克,党参30克,炙黄芪9克,炒白术30克,茯苓9克,焦神曲20克,焦麦芽20克,焦山楂 20克,甘草6克,香橼18克,佛手18克。
实施例3:
一种用于新冠肺炎治疗的中药组合物,每剂包含以下组分:肉苁蓉10克,桂枝12克,党参9克,炙黄芪30克,炒白术6克,茯苓15克,焦神曲20克,焦麦芽20克,焦山楂 20克,甘草9克,香橼6克,佛手6克。
实施例4:
一种用于新冠肺炎治疗的中药组合物,每剂包含以下组分:肉苁蓉20克,桂枝5克,党参20克,炙黄芪9克,炒白术30克,茯苓9克,焦神曲20克,焦麦芽20克,焦山楂 20克,甘草6克,香橼18克,佛手18克。
实施例5:
一种用于新冠肺炎治疗的中药组合物,每剂包含以下组分:肉苁蓉10克,桂枝15克,党参9克,炙黄芪30克,炒白术6克,茯苓15克,焦神曲9克,焦麦芽9克,焦山楂9 克,甘草9克,香橼6克,佛手6克,藿香5克,佩兰12克,厚朴8克,草豆蔻12克,炒薏苡仁25克。患者服用一周后,出现舌苔厚腻减轻,乏力、体倦明显改善。
实施例6:
一种用于新冠肺炎治疗的中药组合物,每剂包含以下组分:肉苁蓉10克,桂枝15克,党参9克,炙黄芪30克,炒白术6克,茯苓15克,焦神曲9克,焦麦芽9克,焦山楂9 克,甘草9克,香橼6克,佛手6克,藿香10克,佩兰8克,厚朴12克,草豆蔻12克,炒薏苡仁35克。患者服用5天后,出现舌苔厚腻减轻,乏力、体倦明显改善。
实施例7:
一种用于新冠肺炎治疗的中药组合物,每剂包含以下组分:肉苁蓉10克,桂枝15克,党参9克,炙黄芪30克,炒白术6克,茯苓15克,焦神曲9克,焦麦芽9克,焦山楂9 克,甘草9克,香橼6克,佛手6克,柴胡8克,郁金12克。患者服用药物后神疲焦躁、终日惶惶症状明显减轻。
实施例8:
一种用于新冠肺炎治疗的中药组合物,每剂包含以下组分:肉苁蓉10克,桂枝15克,党参9克,炙黄芪30克,炒白术6克,茯苓15克,焦神曲9克,焦麦芽9克,焦山楂9 克,甘草9克,香橼6克,佛手6克,柴胡12克,郁金9克。患者服用药物后神疲焦躁、终日惶惶症状明显减轻。
实施例9:
一种用于新冠肺炎治疗的中药组合物,每剂包含以下组分:肉苁蓉10克,桂枝15克,党参9克,炙黄芪30克,炒白术6克,茯苓15克,焦神曲9克,焦麦芽9克,焦山楂9 克,甘草9克,香橼6克,佛手6克,炒酸枣仁12克,磁石35克,龙骨9克,牡蛎9克。患者服用药物后,夜魅不安,心急如潮、睡浅易惊症状明显改善。
实施例10:
一种用于新冠肺炎治疗的中药组合物,每剂包含以下组分:肉苁蓉10克,桂枝15克,党参9克,炙黄芪30克,炒白术6克,茯苓15克,焦神曲9克,焦麦芽9克,焦山楂9 克,甘草9克,香橼6克,佛手6克,炒酸枣仁18克,磁石25克,龙骨45克,牡蛎45 克。患者服用药物后,夜魅不安,心急如潮、睡浅易惊症状明显改善。
实施例11:
一种用于新冠肺炎治疗的中药组合物,每剂包含以下组分:肉苁蓉10克,桂枝15克,党参9克,炙黄芪30克,炒白术6克,茯苓15克,焦神曲9克,焦麦芽9克,焦山楂9 克,甘草9克,香橼6克,佛手6克,柴胡8克,法半夏12克,黄芩12克,干姜7克。患者服药后,气急如火,口舌干燥,疔疮频发症状改善。
实施例12:
一种用于新冠肺炎治疗的中药组合物,每剂包含以下组分:肉苁蓉10克,桂枝15克,党参9克,炙黄芪30克,炒白术6克,茯苓15克,焦神曲9克,焦麦芽9克,焦山楂9 克,甘草9克,香橼6克,佛手6克,柴胡12克,法半夏9克,黄芩18克,干姜5克。患者服药后,气急如火,口舌干燥,疔疮频发症状改善。
二、用法与用量
(一)临证加减:
本申请实施例中,以肉苁蓉,桂枝,党参,炙黄芪,炒白术,茯苓,焦神曲,焦麦芽,焦山楂,甘草,香橼,佛手构成的配方为治疗新冠肺炎的基础组方。实施例1~4为示例性基础组方。
在此基础上根据临床症状可以加减其他合理的组分。下面以示例性实施例对本申请实施例中的临证加减进行说明。
功能:温阳益气,和中健脾。
主治:普通新冠肺炎患者,身困乏力,精神不振,食欲下降(纳呆),周身酸痛,烦躁易怒,舌质红,苔白微腻,脉濡或滑。
若兼痰湿困脾,证见身肢困倦,纳呆乏力,舌胖齿痕苔腻,可加藿香、佩兰、厚朴、草豆蔻、炒薏苡仁,见实施例5、6。
若兼肝郁气滞,轻则情绪烦躁,可加柴胡、郁金,见实施例7、8;重则急躁易怒、失眠,可加炒酸枣仁、磁石、龙骨、牡蛎,见实施例9、10。
若兼邪犯少阳、枢机不利,证见寒热往来,口苦咽干,可加柴胡、法半夏、黄芩、干姜,见实施例11、12。
(二)服用方法:将实施例1~12所得中药组合物水煎400mL,每日1剂,分2次服用,早晚各1次温服。
水煎的具体方法,以医院所用煎药机煎药法为说明。
(1)浸泡:将处方所需中药,倒入过滤袋,扎紧熬药袋口(预留足够吸水膨胀空间),按每剂1500~2000mL水浸泡在泡药桶2小时。
(2)熬药:浸泡时间到,将药袋连同浸泡水倒进煎药机,保留大于1500mL水量,设定好煎药时间(1小时以上浓煎)。患者熬药信息号牌一并夹在熬药机上,以防出错。盖好煎药机盖子,关好阀门,开始煎药。
(3)包装:煎药时间到,打开煎药机盖,提起煎药机过滤网,按每付药600mL,留取400mL,分二袋包装。
(4)发药:两袋药物400mL,分2次服用,早晚各1次温服。
(三)辅助膳食:
当归生姜羊肉汤(《金匮要略》)加减:当归9g,生姜15g,肉苁蓉10g,枸杞10g,佛手5g,羊肉500g为一日用度。
水煎,不拘时饮其汤;可佐食其肉,以能食为度。
药物服用同时,药膳合用,效果更好。处方机理一致,增加临床效果。
三、临床疗效比较
(一)用药方案
1、西医组主要用药方案:
西药以盐酸阿比多尔、重组人干扰素α1b、重组人干扰素α2b等抗病毒西药为主。其中盐酸阿比多尔每次剂量0.2g,一天3次,口服;重组人干扰素α1b每次剂量30μg,一天 2次,雾化吸入;重组人干扰素α2b每次剂量10喷,一天2次,吸入。
2、中药组主要用药方案:
每剂包含以下组分:炙甘草6g,杏仁9g,生石膏20g(先煎),桂枝9g,泽泻9g,猪苓9g,白术9g,茯苓15g,柴胡16g,黄芩6g,姜半夏9g,生姜9g,紫菀9g,冬花 9g,射干9g,细辛6g,山药12g,枳实6g,陈皮6g,藿香9g。服法:水煎服,每天一付,早晩各一次(饭后四十分钟),温服,三付一个疗程。如有条件,每次服完药可加服大米汤半碗,舌干津液亏虚者可多服至一碗。(注:如患者不发热则生石膏的用量要小,发热或壮热可加大生石膏用量)。若症状好转而未痊愈则服用第二个疗程,若患者有特殊情况或其他基础病,第二疗程可以根据实际情况修改处方,症状消失则停药。
3、中西医组主要用药方案:
作为治疗新型冠状病毒肺炎的中西药组合物,中药以清肺排毒汤为主,每剂包含以下组分:炙甘草6g,杏仁9g,生石膏20g(先煎),桂枝9g,泽泻9g,猪苓9g,白术9g,茯苓15g,柴胡16g,黄芩6g,姜半夏9g,生姜9g,紫菀9g,冬花9g,射干9g,细辛6g,山药12g,枳实6g,陈皮6g,藿香9g。服法:传统中药饮片,水煎服。每天一付,早晩各一次(饭后四十分钟),温服,三付一个疗程。如有条件,每次服完药可加服大米汤半碗,舌干津液亏虚者可多服至一碗。(注:如患者不发热则生石膏的用量要小,发热或壮热可加大生石膏用量)。若症状好转而未痊愈则服用第二个疗程,若患者有特殊情况或其他基础病,第二疗程可以根据实际情况修改处方,症状消失则停药。西药以盐酸阿比多尔、重组人干扰素α1b、重组人干扰素α2b等抗病毒西药为主。其中中药用法用量同中药治疗组,西药盐酸阿比多尔每次剂量0.2g,一天3次,口服;重组人干扰素α1b每次剂量30μg,一天2次,雾化吸入;重组人干扰素α2b每次剂量10喷,一天2次,吸入。
4、申请实施例用药方案:
本申请实施例的用药方案采用实施例1-4。用于治疗新冠肺炎属热毒袭肺证,症见发热或高热,恶寒,肌肉酸痛,鼻塞流涕,咳嗽,头痛,咽干咽痛,舌偏红,苔黄或黄腻等。用法用量,七剂,煎药一天2次,口服。另,若见身肢困倦,纳呆乏力,舌胖齿痕苔腻,采用实施例5-6,加藿香、佩兰、厚朴、草豆蔻、炒薏苡仁,通阳利湿,醒脾开胃。若见肝郁气滞、情绪烦躁,采用实施例7-8,可加柴胡、郁金疏肝解郁,泻火安神。若见急躁易怒、失眠,采用实施例9-10,可加炒酸枣仁、磁石、龙骨、牡蛎,镇惊安神,除烦促眠。若见寒热往来,口苦咽干,采用实施例11-12,可加柴胡、法半夏、黄芩、干姜升清降浊,调畅中枢,和其表里。
(二)四组患者基线特征
COVID-19诊断标准参照《新型冠状病毒肺炎诊疗方案(试行第八版)》,对新疆医科大学第六附属医院和第八附属医院的307例COVID-19患者(表1)进行了横断面研究,以评价本申请实施例方组的疗效。其中,单独应用西药治疗的患者26例,单独应用中药治疗的患者94例,应用中西医结合治疗的患者116例,应用本申请实施例方治疗的患者 71例。各组间性别与年龄的差异无统计学意义(P>0.05)。
表1各组样本年龄与性别的比较
注:年龄用均数±标准误表示
(三)疗效分析
1.四组患者间病毒核酸转阴天数、治疗7天后转阴率及治疗期间复阳率的比较
病毒核酸检测采用上海之江生物新型冠状病毒(2019-nCoV)核酸测定试剂盒(三重荧光PCR法),从入院时间开始到病毒核酸检测转为阴性的时间,西药组平均为13天,中药组平均为11天,中西医结合组平均为13天,本申请实施例方组平均为7天。由图1 可知,本申请实施例方组患者转阴所需天数相较于西药组、中药组和中西医结合组显著缩短(p<0.05)。药物治疗7天后,西药组转阴率38.50%、中药组转阴率42.6%、中西医结合组转阴率58.60%、本申请实施例方组转阴率78.9%。说明本申请实施例方组治疗7 天的转阴率较其他组更高(p<0.05)(见图2)。计算各组转阴后2周内的复阳率发现,西药组复阳率61.50%、中药组复阳率50%、中西医结合组复阳率42.20%、本申请实施例方组复阳率2.8%。本申请实施例方组复阳率明显低于其他组(见图3)。综合上述结果说明本申请实施例方组7天转阴速率快且转阴后2周内的复阳率低。
2.四组患者治疗后一般症状的比较
治疗一周后,西药组咽痛症状明显缓解,中药组咽痛症状缓解率为9.09%,但两组的咳嗽、乏力症状均未缓解;中西医治疗组咳嗽、乏力症状缓解率分别为35.71%、20%;本申请实施例方组咽痛、乏力症状均缓解,咳嗽症状缓解率为75%。表明本申请实施例方治疗一周后,患者咽痛、乏力、咳嗽等一般症状与其他组比较明显缓解。
治疗三周后,西药组除乏力症状外,其余症状明显缓解;中药组咳嗽、乏力明显缓解,咽痛症状缓解率为81.82%;中西医治疗组咳嗽明显缓解,咳嗽及乏力症状缓解率均在80%以上;本申请实施例方治疗组的各项症状均显著缓解,且三周期间上述症状无反复出现。
3.不同组患者治疗前后血常规指标的变化
治疗后血常规相关数据(白细胞计数、中性粒细胞计数、淋巴细胞计数以及C反应蛋白含量)的研究结果(表2~5)显示:与治疗前比较,西药组只有C反应蛋白在治疗三周后显著降低(p<0.05),其他结果差异均无统计学意义。中药组治疗一周后淋巴细胞计数明显升高,治疗三周后白细胞计数、中性粒细胞计数以及淋巴细胞计数显著升高(p<0.05)。中西医结合组治疗一周后白细胞、淋巴细胞计数明显升高,而C反应蛋白降低,本申请实施例方组治疗一周后白细胞、中性粒细胞计数明显升高。中西医结合组治疗和本申请实施例方组治疗三周后白细胞计数、中性粒细胞计数以及淋巴细胞计数均显著升高(p<0.05)。对白细胞和中性粒细胞计数的增加量的比较发现,治疗一周后,本申请实施例方组白细胞的增加量(1.74×109/L)大于西药组(0.89×109/L)、中药组(1.23×109/L)和中西医结合治疗组(0.99×109/L);本申请实施例方组中性粒细胞的增加量(0.77×109/L)大于中药组 (0.25×109/L)和中西医结合治疗组(0.03×109/L)。以上结果表明本申请实施例方治疗组治疗一周后升高白细胞和中性粒细胞的作用更显著。
表2西药治疗前后血常规变化的比较
表3中药治疗前后血常规变化的比较
表4中西医结合治疗前后血常规变化的比较
表5本申请实施例方治疗前后血常规变化的比较
注:上计量资料用中位数(四分位数间距)表示。*表示与治疗前比较P<0.05。
4.四组患者治疗后CT结果的比较
观察各组COVID-19患者治疗前CT影像学结果显示:“两下肺间质性肺炎,胸膜局部增厚、粘连,两肺上叶尖段少许纤维索条影”、“肺下叶间质性渗出,双肺下叶野轻度间质性改变,右肺中叶少许纤维索条影”、“双肺胸膜下散在结节,部分密度较高,肺段胸膜下小结节样致密影,侧局部胸膜肥厚、粘连”或者“双肺少量纤维灶,双肺渗出,考虑炎症,双侧胸腔少量积液”。
治疗后四组患者上述CT影像学结果显示:西药治疗组炎症缓解率38%,中药组炎症缓解率61%,中西药组炎症缓解率43%,本申请实施例方组炎症缓解率75%。本申请实施例方组较其他四组炎症吸收率明显升高(图4)。
5.疗效总结
COVID-19患者入院后,在对症治疗的基础上分别应用西药、中药、中西医结合和本申请实施例方治疗,对四种治疗方式的疗效进行了归纳总结。结果表明,从入院时间开始病毒核酸转为阴性的时间,本申请实施例方组患者转阴所需天数相较于西药组、中药组和中西医结合组显著缩短。计算各组转阴后的复阳率发现本申请实施例方组复阳率明显低于其他组,结果说明本申请实施例方组7天转阴速率快且之后的复阳率低。
基于上述疗效判断主要指标的分析,申请人进一步对治疗后一般症状缓解、血常规和影像学变化进行分析,结果表明本申请实施例方组能够改善咽痛、乏力和咳嗽的症状,促进肺部炎症吸收,且治疗后白细胞和中性粒细胞明显升高,进而缩短患者病程和转阴时间。
另外,患者服用临证加减个性化用药2周后,与西药、中药、中西医结合组相比,临证加减实施例组对新冠肺炎的治疗效果与基础组方实施例效果相同。除此之外。身肢困倦,纳呆乏力临证加减实施例方组,舌胖齿痕苔腻患者服药后舌苔厚腻减轻,乏力、体倦明显改善。肝郁气滞、情绪烦躁患者服物后神疲焦躁、终日惶惶症状明显减轻。急躁易怒、失眠患者服药后,情绪急躁易怒、失眠易惊症状明显改善。寒热往来,口苦咽干患者服药后,气急如火、寒热往来、口舌干燥、疔疮频发症状改善。
6.本申请实施例方安全性评价
所有患者在治疗期间均进行了安全性评价,包括血常规、尿常规、肝肾功、心电图等,未见明显不良反应。
上述虽然结合附图对本发明的具体实施方式进行了描述,但并非对本发明保护范围的限制,在本发明的技术方案的基础上,本领域技术人员不需要付出创造性劳动即可做出的各种修改或变形仍在本发明的保护范围以内。
Claims (9)
1.一种用于新型冠状病毒肺炎治疗的中药组合物,其特征在于,由以下重量份的组分制成:肉苁蓉10~30份,桂枝3~15份,党参9~30份,炙黄芪9~30份,炒白术6~30份,茯苓9~15份,焦神曲6~20份,焦麦芽9~20份,焦山楂9~20份,甘草1.5~9份,香橼6~18份,佛手6~18份。
2.根据权利要求1所述的一种用于新型冠状病毒肺炎治疗的中药组合物,其特征在于,由以下重量份的组分制成:肉苁蓉10~20份,桂枝5~12份,党参9~20份,炙黄芪9~30份,炒白术6~30份,茯苓9~15份,焦神曲6~20份,焦麦芽9~20份,焦山楂9~20份,甘草1.5~9份,香橼6~18份,佛手6~18份。
3.一种用于新型冠状病毒肺炎治疗的中药组合物,其特征在于,由以下重量份的组分制成:肉苁蓉10~30份,桂枝3~15份,党参9~30份,炙黄芪9~30份,炒白术6~30份,茯苓9~15份,焦神曲6~20份,焦麦芽9~20份,焦山楂9~20份,甘草1.5~9份,香橼6~18份,佛手6~18份,藿香3~18份,佩兰3~18份,厚朴3~18份,草豆蔻3~18份,炒薏苡仁9~35份。
4.一种用于新型冠状病毒肺炎治疗的中药组合物,其特征在于,由以下重量份的组分制成:肉苁蓉10~30份,桂枝3~15份,党参9~30份,炙黄芪9~30份,炒白术6~30份,茯苓9~15份,焦神曲6~20份,焦麦芽9~20份,焦山楂9~20份,甘草1.5~9份,香橼6~18份,佛手6~18份,柴胡3~12份,郁金3~18份。
5.一种用于新型冠状病毒肺炎治疗的中药组合物,其特征在于,由以下重量份的组分制成:肉苁蓉10~30份,桂枝3~15份,党参9~30份,炙黄芪9~30份,炒白术6~30份,茯苓9~15份,焦神曲6~20份,焦麦芽9~20份,焦山楂9~20份,甘草1.5~9份,香橼6~18份,佛手6~18份,炒酸枣仁9~30份,磁石9~30份,龙骨9~45份,牡蛎9~45份。
6.一种用于新型冠状病毒肺炎治疗的中药组合物,其特征在于,由以下重量份的组分制成:肉苁蓉10~30份,桂枝3~15份,党参9~30份,炙黄芪9~30份,炒白术6~30份,茯苓9~15份,焦神曲6~20份,焦麦芽9~20份,焦山楂9~20份,甘草1.5~9份,香橼6~18份,佛手6~18份,柴胡3~12份,法半夏3~12份,黄芩3~18份,干姜3~9份。
7.一种用于新型冠状病毒肺炎治疗的制剂,其特征在于,其有效成分为权利要求1~6中任一项所述中药组合物。
8.根据权利要求7所述的制剂,其特征在于,所述制剂形式为按照常规方法制备的汤剂、颗粒、胶囊或丸剂。
9.权利要求1~6中任一项所述中药组合物在制备新型冠状病毒肺炎治疗药物中的应用。
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