CN112890948B

CN112890948B - Electric pulse ablation device capable of cooperatively administering medicine

Info

Publication number: CN112890948B
Application number: CN202110105728.0A
Authority: CN
Inventors: 杨彪
Original assignee: West China Hospital of Sichuan University
Current assignee: West China Hospital of Sichuan University
Priority date: 2021-01-26
Filing date: 2021-01-26
Publication date: 2022-03-01
Anticipated expiration: 2041-01-26
Also published as: CN112890948A

Abstract

The invention relates to the technical field of medical appliances, and the scheme is that an electric pulse ablation device capable of realizing cooperative drug delivery comprises an endoscope tube and a drug delivery ablation assembly, wherein the drug delivery ablation assembly comprises an interventional catheter, and the front end of the endoscope tube is provided with a tube fixing piece; the operation of injecting liquid medicine can be carried out through the interventional catheter, and the ablation technology is combined with the liquid medicine, so that the treatment effect of the tumor can be effectively improved; according to the invention, the electric push-pull mechanism can drive the expansion body and the electrode to move relatively, and the tips of the two groups of electrodes which are pricked into tumor tissues can be far away from each other by combining the wedge-shaped convex blocks arranged on the electrode, so that the ablation diameter is greatly increased, the applicability of electric pulse ablation is improved, and the difficulty of ablation operation is simplified.

Description

Electric pulse ablation device capable of cooperatively administering medicine

Technical Field

The invention relates to the technical field of medical appliances, in particular to an electric pulse ablation device capable of cooperatively dosing.

Background

Compared with the traditional surgical operation, the medical endoscope has the characteristics of flexible, simple and direct operation in the surgical operation and routine medical examination, greatly improves the diagnosis capability and improves the working efficiency.

The medical endoscope utilizes natural holes of human body or opens a plurality of small holes when necessary, and doctors only need to skillfully insert the endoscope lens into the body, and can carry out closed operation in the body through other surgical instruments and a camera display system. Functional minimally invasive surgery with medical endoscopes has gained wide acceptance by doctors and patients, and medical endoscopic techniques are widely used in almost all departments of hospitals.

The radiofrequency ablation can be performed through the femoral artery and vein, the internal jugular vein and the subclavian vein, the electrode catheter is inserted into the heart, an abnormal electrical conduction channel or an abnormal beating point in the heart is found by an electrophysiological mapping technology, and an electrode at the top end of the large-head catheter is used for generating a resistance electrothermal effect in myocardial tissues to dry and necrose myocardial cells so as to achieve the purpose of treating tachyarrhythmia; the radiofrequency ablation can also be directly punctured into the tumor tissue under the guidance of an imaging device, and the tumor tissue is cauterized and necrosed by utilizing the electric heating effect generated by the electrode in the tissue, so that the purpose of ablating and inactivating the tumor cells is achieved.

The combination of the radio frequency ablation technology and the medical endoscope is a technical research direction for effectively improving the ablation use effect.

At present, the needle rod of the radio frequency ablation electrode needle adopts a hard metal tube which is only suitable for the radio frequency ablation through the percutaneous puncture.

In addition, the existing ablation equipment using the double-needle parallel electrodes has the advantages that the distance between the two electrodes is fixed, the size of a generated electric field is fixed, the size of the electric field cannot be adjusted along with the ablation section of a tumor in the advancing process of the electrodes, so that the effect can be achieved only by multiple operations, and the ablation effect is poor.

Based on the scheme, the electric pulse ablation device capable of realizing synergistic drug delivery is designed to solve the problems.

Disclosure of Invention

The present invention is directed to an electrical pulse ablation device with synergistic drug delivery to solve the above-mentioned problems of the prior art.

In order to achieve the purpose, the invention provides the following technical scheme: an electric pulse ablation device capable of cooperatively dosing comprises an endoscope tube and a dosing ablation assembly, wherein the dosing ablation assembly comprises an interventional catheter, a tube fixing piece is arranged at the front end of the endoscope tube, the front end of the interventional catheter is fixedly installed through the tube fixing piece, two groups of electrode sleeves are correspondingly arranged on the inner wall of the interventional catheter along the length square, electrodes are inserted in the electrode sleeves in a sliding mode, a push-pull rod is arranged in the middle of an inner cavity of the interventional catheter, an expansion body is arranged at the front end of the push-pull rod, wedge-shaped convex blocks are symmetrically arranged between the two groups of opposite electrodes and close to the front end of the two groups of opposite electrodes, and the expansion body is located in the middle of the two groups of wedge-shaped convex blocks;

an end plate is fixedly arranged at the tail end of the interventional catheter, a first motor is arranged at the upper part of the other side of the end plate, a first lead screw is arranged at the output end of the first motor, a polished rod is arranged on the lower side of the first lead screw in parallel, a shell is arranged between the first lead screw and the polished rod, bumps are correspondingly arranged on the upper side and the lower side of the shell, the first lead screw is in threaded connection with the bumps penetrating through the upper side, the polished rod movably penetrates through the bumps on the lower side, two groups of electrodes are fixedly connected with the shell and are connected with pulse generation equipment through wires on the electrodes, an electric push-pull mechanism is arranged on the inner side of the shell, and the movable end of the electric push-pull mechanism is connected with the tail end of a push-pull rod;

the end plate is provided with a medicine injection port, and the medicine injection port is connected with medicine supply equipment through a hose.

Preferably, the electric push-pull mechanism comprises a fixed sleeve, a hollow rod is inserted into the fixed sleeve, a second screw rod is rotatably arranged in the middle of the fixed sleeve, and the right end of the second screw rod penetrates through the shell and is connected with a second motor.

Preferably, the first motor and the second motor are both stepping motors.

Preferably, the electrode sleeve is made of an insulating material.

Preferably, the discharge ends of both sets of electrodes are pointed ends, and the tumor tissue is pierced by the pointed ends and ablated by discharging between the pointed ends.

Preferably, the expansion body is a sphere, a plurality of through holes from top to bottom are uniformly distributed on the sphere, and the top end of the sphere is fixedly connected with the push-pull rod.

Preferably, the expansion body is a cone, a plurality of medicine feeding notches are uniformly distributed on the inclined plane of the cone, and the top end of the cone is fixedly connected with the push-pull rod.

Compared with the prior art, the invention has the beneficial effects that:

1. the invention can be used for non-invasive or minimally-invasive intervention on a patient, an interventional catheter is inserted into the body through an endoscope channel or a percutaneous opening channel through a natural cavity of the human body, and then an electric pulse is used for ablating a tumor part;

2. the invention can also carry out the operation of liquid medicine injection through the interventional catheter, and the ablation technology is combined with the liquid medicine for use, thereby effectively improving the treatment effect of the tumor;

3. according to the invention, the electric push-pull mechanism can drive the expansion body and the electrode to move relatively, and the tips of the two groups of electrodes which are pricked into tumor tissues can be far away from each other by combining the wedge-shaped convex blocks arranged on the electrode, so that the ablation diameter is greatly increased, the applicability of electric pulse ablation is improved, and the difficulty of ablation operation is simplified.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is an enlarged view taken at A in FIG. 1 according to the present invention;

FIG. 3 is an enlarged view of the invention at B of FIG. 1;

FIG. 4 is a schematic structural view of an electric push-pull mechanism according to the present invention;

FIG. 5 is a schematic cross-sectional view of an interventional catheter of the present invention;

FIG. 6 is a schematic view of a first embodiment of the stent of the present invention;

FIG. 7 is a schematic structural view of a second embodiment of the stent of the present invention;

FIG. 8 is a schematic view of the present invention about to be inserted into a tumor tissue;

FIG. 9 is a schematic view of the present invention inserted into tumor tissue without the tip being extended;

FIG. 10 is a schematic view of the present invention inserted into tumor tissue with the tip end deployed.

The reference numbers are as follows:

1-endoscope tube, 2-interventional catheter, 3-pulse generating device, 4-drug supply device, 5-electrode sleeve, 6-electrode, 7-tube fixing piece, 8-push-pull rod, 9-wedge-shaped lug, 10-expanding body, 11-end plate, 12-shell, 13-lug, 14-electric push-pull mechanism, 15-first motor, 16-first screw rod, 17-polished rod, 18-drug injection port, 19-hose, 101-through hole, 102-drug administration notch, 141-fixing sleeve, 142-hollow rod, 143-second screw rod and 144-second motor.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example one

Referring to fig. 1 to 5 and fig. 8 to 10, the present embodiment provides a technical solution: an electric pulse ablation device capable of cooperatively dosing comprises an endoscope tube 1 and a dosing ablation assembly, wherein the dosing ablation assembly comprises an interventional catheter 2, a tube fixing part 7 is arranged at the front end of the endoscope tube 1, the front end of the interventional catheter 2 is fixedly installed through the tube fixing part 7, two groups of electrode sleeves 5 are correspondingly arranged on the inner wall of the interventional catheter 2 along the length square, electrodes 6 are inserted in the electrode sleeves 5 in a sliding mode, a push-pull rod 8 is arranged in the middle of the inner cavity of the interventional catheter 2, an expansion body 10 is arranged at the front end of the push-pull rod 8, wedge-shaped convex blocks 9 are symmetrically arranged between the two groups of opposite electrodes 6 and close to the front ends of the two groups of opposite electrodes 6, and the expansion body 10 is located in the middle of the two groups of wedge-shaped convex blocks 9;

an end plate 11 is fixedly arranged at the tail end of the interventional catheter 2, a first motor 15 is arranged at the upper part of the other side of the end plate 11, a first lead screw 16 is arranged at the output end of the first motor 15, a polished rod 17 is arranged on the lower side of the first lead screw 16 in parallel, a shell 12 is arranged between the first lead screw 16 and the polished rod 17, bumps 13 are correspondingly arranged on the upper side and the lower side of the shell 12, the first lead screw 16 is in threaded connection with the bumps 13 which penetrate through the upper side, the polished rod 17 movably penetrates through the bumps 13 on the lower side, two groups of electrodes 6 are fixedly connected with the shell 12 and are connected with the pulse generating equipment 3 through conducting wires on the electrodes, an electric push-pull mechanism 14 is arranged on the inner side of the shell 12, and the movable end of the electric push-pull mechanism 14 is connected with the tail end of a push-pull rod 8;

the end plate 11 is provided with a medicine injection port 18, and the medicine injection port 18 is connected with the medicine supply device 4 through a hose 19.

Further, the electric push-pull mechanism 14 includes a fixed sleeve 141, a hollow rod 142 is inserted into the fixed sleeve 141, a second lead screw 143 is rotatably disposed in the middle of the fixed sleeve 141, and a second motor 144 is connected to the right end of the second lead screw 143 penetrating through the housing 12.

Further, the first motor 15 and the second motor 144 are both stepping motors.

Further, the electrode sleeve 5 is made of an insulating material.

Further, the discharge ends of the two groups of electrodes 6 are both sharp points, and the tumor tissue is pierced by the sharp points and is ablated by discharging between the sharp points.

The working principle is as follows: when the device is used, as shown in the attached drawing 8, firstly, the administration ablation assembly moves to the position of the tumor tissue in the human body along with the endoscope tube 1, then the first motor 15 is started to drive the first screw rod 16 to rotate, and further the shell 12 is driven to be close to the end plate 11 through the upper side bump 13, the shell 12 pushes the electrode 5 and the push-pull rod 8 to move synchronously, the tip of the electrode 5 pierces the tumor tissue and goes deep into a certain depth, at the moment, the pulse generation device 3 is started to supply power to the two groups of electrodes 6, the tip positions of the two groups of electrodes 6 generate radio frequency pulses to ablate, so that the tumor tissue cells are heated and necrotized, during ablation or after ablation, the medicine supply device 4 can be started, medicine liquid is injected into the interventional catheter 2 through the hose 19, and the medicine liquid is sprayed to the position of the tumor tissue through the interventional catheter 2 to perform auxiliary therapy on the tumor tissue;

however, the size of the tumor tissue of part of patients is large, the conventional ablation operation cannot well meet the requirements due to the limited ablation space, at this time, after the preliminary ablation of the electrode 6 is finished, the second motor 144 is selected to be started, the second screw rod 143 is driven to rotate, the second screw rod 143 rotates to drive the hollow rod 142 to contract into the fixed sleeve 141, the hollow rod 142 contracts to enable the push-pull rod 8 to be pulled, the expansion body 10 moves upwards to press the wedge-shaped convex blocks 9 on the electrode 6, the pointed end of the pierced electrode 6 expands towards two sides, the problem of improving the ablation space is solved, and the applicability of the ablation device is improved.

Example two

Referring to fig. 6, the second embodiment has only the following improvements compared to the first embodiment:

in the second embodiment, the expansion body 10 is a sphere, and a plurality of through holes 101 are uniformly distributed on the sphere from top to bottom, and the top end of the sphere is fixedly connected to the push-pull rod 8.

When the sphere structure moves upwards, the wedge-shaped convex block 9 can be effectively extruded, so that the two groups of electrodes 6 are expanded, and the arranged through holes 101 can reduce the blocking force of the sphere to the liquid medicine.

EXAMPLE III

Referring to fig. 7, the third embodiment has the following improvements compared with the first or second embodiment:

in the third embodiment, the expanding body 10 is a cone, and a plurality of medicine feeding notches 102 are uniformly distributed on the inclined surface of the cone, and the top end of the cone is fixedly connected with the push-pull rod 8.

Compared with a sphere structure, the cone structure is more convenient for the circulation of liquid medicine and has smaller resistance on the premise of keeping the effective expansion electrode 6.

In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

The above disclosure of further embodiments of the invention is intended only to facilitate the explanation of the invention. Further examples are not intended to be exhaustive or to limit the invention to the precise forms disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.

Claims

1. An electric pulse ablation device capable of cooperatively administering medicine, which comprises an endoscope tube (1) and an medicine administration ablation assembly, and is characterized in that: the drug administration ablation assembly comprises an interventional catheter (2), a tube fixing piece (7) is arranged at the front end of the endoscope tube (1), the front end of the interventional catheter (2) is fixedly installed through the tube fixing piece (7), two groups of electrode sleeves (5) are correspondingly arranged on the inner wall of the interventional catheter (2) along the length square, electrodes (6) are inserted in the electrode sleeves (5) in a sliding mode, a push-pull rod (8) is arranged in the middle of the inner cavity of the interventional catheter (2), an expansion body (10) is arranged at the front end of the push-pull rod (8), wedge-shaped convex blocks (9) are symmetrically arranged between the two groups of opposite electrodes (6) close to the front end of the two groups of opposite electrodes, and the expansion body (10) is located in the middle of the two groups of wedge-shaped convex blocks (9);

an end plate (11) is fixedly arranged at the tail end of the interventional catheter (2), a first motor (15) is arranged at the upper part of the other side of the end plate (11), a first screw rod (16) is arranged at the output end of the first motor (15), a polish rod (17) is arranged in parallel at the lower side of the first screw rod (16), a shell (12) is arranged between the first screw rod (16) and the polish rod (17), the upper side and the lower side of the shell (12) are correspondingly provided with a lug (13), the first screw rod (16) is in threaded connection with the lug (13) penetrating through the upper side, the polish rod (17) movably penetrates through the lug (13) at the lower side, the two groups of electrodes (6) are fixedly connected with the shell (12) and are connected with the pulse generating equipment (3) through the leads on the electrodes, an electric push-pull mechanism (14) is arranged on the inner side of the shell (12), and the movable end of the electric push-pull mechanism (14) is connected with the tail end of a push-pull rod (8);

be equipped with injection mouth (18) on end plate (11), injection mouth (18) are connected with confession medicine equipment (4) through hose (19).

2. The electric pulse ablation device with synergistic drug delivery according to claim 1, wherein: the electric push-pull mechanism (14) comprises a fixed sleeve (141), a hollow rod (142) is inserted into the fixed sleeve (141), a second screw rod (143) is rotatably arranged in the middle of the fixed sleeve (141), and a second motor (144) penetrates through the shell (12) and is connected to the right end of the second screw rod (143).

3. A synergistically drug-administrable electric pulse ablation device according to claim 2, wherein: the first motor (15) and the second motor (144) are both stepping motors.

4. The electric pulse ablation device with synergistic drug delivery according to claim 1, wherein: the electrode sleeve (5) is made of insulating materials.

5. The electric pulse ablation device with synergistic drug delivery according to claim 1, wherein: the discharge ends of the two groups of electrodes (6) are pointed ends, and the tumor tissue is pierced by the pointed ends and is ablated by discharging between the pointed ends.

6. The electric pulse ablation device capable of synergistic drug delivery according to any one of claims 1 to 5, characterized in that: the expansion body (10) is a sphere, a plurality of through holes (101) from top to bottom are uniformly distributed on the sphere, and the top end of the sphere is fixedly connected with the push-pull rod (8).

7. The electric pulse ablation device capable of synergistic drug delivery according to any one of claims 1 to 5, characterized in that: the expanding body (10) is a cone, a plurality of medicine feeding notches (102) are uniformly distributed on the inclined surface of the cone, and the top end of the cone is fixedly connected with the push-pull rod (8).