CN112881677B - Water bath heating type biological reagent reaction box - Google Patents
Water bath heating type biological reagent reaction box Download PDFInfo
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- CN112881677B CN112881677B CN202110036392.7A CN202110036392A CN112881677B CN 112881677 B CN112881677 B CN 112881677B CN 202110036392 A CN202110036392 A CN 202110036392A CN 112881677 B CN112881677 B CN 112881677B
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- water
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 89
- 238000010438 heat treatment Methods 0.000 title claims abstract description 65
- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 49
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 45
- 239000007788 liquid Substances 0.000 claims abstract description 7
- 230000006698 induction Effects 0.000 claims description 14
- 238000012360 testing method Methods 0.000 claims description 9
- 238000004891 communication Methods 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 6
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- 230000000670 limiting effect Effects 0.000 claims description 3
- 238000009434 installation Methods 0.000 claims 2
- 238000000034 method Methods 0.000 description 8
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- 239000003124 biologic agent Substances 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
Abstract
The invention discloses a water bath heating type biological reagent reaction box, which comprises a box body, a heating cylinder, a cover body, a carrying device and a motor, wherein the carrying device is connected with the heating cylinder through a liquid discharge pipe, the liquid discharge pipe is connected with the upper part of a right side plate of the box body through a return pipe, the carrying device comprises a conversion bin, a retaining cylinder and a pump cylinder, a sliding seat is connected in the pump cylinder in a sliding manner, an inner cavity of the pump cylinder is communicated with an inner cavity of the cover body through a water inlet, a first one-way valve is arranged in the water inlet, the pump cylinder is communicated with the conversion bin through a water outlet, and a second one-way valve is arranged in the water outlet.
Description
Technical Field
The invention relates to the technical field of medical appliances, in particular to a water bath heating type biological reagent reaction kit.
Background
Biological agents refer to biological materials or organic compounds involved in life science research, and agents for clinical diagnosis and medical research. Because of wide life science range and quick development, the reagent has various varieties and complex properties. The main components include electrophoresis reagent, chromatographic reagent, centrifugal separation reagent, immunological reagent, labeling reagent, histochemical reagent, permeabilizer and cancerogenic substance, pesticide, culture medium, buffer, electron microscope reagent, protein and nucleic acid precipitant, condensing agent, ultrafiltration membrane, clinical diagnosis reagent, coloring agent, antioxidant, mildew preventive, detergent and surfactant, biochemical standard reagent, biochemical quality control reagent, separating material, etc.
In the medical field, the inspected specimens are often required to be made into biological reagents, then the biological reagents are reacted in a kit, most of the biological reagents can be better reacted under a certain temperature condition, and the reagents need to be heated, so that the existing biological kits generally do not have the function of water bath heating, and therefore, a special water bath heating device is required to heat the biological reagents in a water bath.
In the water bath heating device in the prior art, the following disadvantages exist in the process of heating biological reagents: firstly, it can only heat a single tube at a time, while in the medical field, the number of samples required per day is relatively large, thus making the efficiency relatively low; secondly, in the water area heating process, the heated water is kept in a static state, so that the water bath heating is not uniform enough, the water bath heating effect is affected, and the reaction effect of the biological reagent is poor.
Disclosure of Invention
In order to solve the problems, the invention provides a water bath heating type biological reagent reaction kit, which is realized by the following technical scheme.
A water bath heating type biological reagent reaction box comprises a box body, a heating cylinder, a cover body, a carrying device and a motor; the box body is open cuboid cavity structure in top, is equipped with the test-tube rack in the box body, the heating cylinder passes through fixed sleeve fixed mounting at the posterior lateral plate outer wall of box body, and the rigid coupling has cylindric hot plate in the heating cylinder, and the right-hand member rigid coupling of heating cylinder has the back flow, the head of back flow is connected with the right side board upper portion of box body, the cover body rigid coupling is at the left side board outer wall of box body, and the left side board of box body corresponds the position of cover body cavity lower part and vertically evenly is equipped with a plurality of intercommunicating pores, the intercommunicating pore switches on the inner chamber of box body and cover body, handling device sets up in the cover body, and handling device's export is connected with the left end of heating cylinder through the fluid-discharge tube, the preceding curb plate outer wall rigid coupling of box body has the mount pad, motor drive at the mount pad, motor drive handling device work.
Further, the upper part of the right side plate of the box body is longitudinally and uniformly fixedly connected with auxiliary pipes, the right end of each auxiliary pipe is integrally fixedly connected with a main pipe, and the return pipe is connected between the right end of the heating cylinder and the rear end of the main pipe.
Further, the carrying device comprises a conversion bin, an indwelling cylinder and a pump cylinder; the switching bin is arranged in the cover body, the switching bin is of a cuboid cavity structure, the rear end of the switching bin is fixedly connected with a water pipe communicated with the inner cavity of the switching bin, the water pipe is rotationally connected with the rear side plate of the cover body, a water outlet is densely distributed on the water pipe outside the cover body, a rotating shaft is fixedly connected on the front side plate of the switching bin, the rotating shaft is rotationally connected with the front side plate of the cover body, a driving wheel is fixedly connected on the head of the rotating shaft, a driving wheel is fixedly connected on the output shaft of the motor, the driving wheel is linked with the driving wheel through a belt, the retaining cylinder is fixedly connected on the outer wall of the rear side plate of the cover body and covers the water pipe in the driving wheel, two ends of the liquid discharge pipe are respectively connected with the retaining cylinder and the heating cylinder, the pump cylinder is fixedly connected on the outer wall of the switching bin, a water inlet is uniformly fixedly connected on the circumference of the position of the pump cylinder close to the switching bin, a first one-way valve is arranged in the water inlet, the direction allowing fluid to pass through the inner cavity of the cover body is pointed towards the inner cavity of the pump cylinder, a water outlet is fixedly connected on the switching bin side plate of the cover body, a second one-way valve is arranged in the water outlet, the direction allowing fluid to pass through the pump cylinder is pointed towards the inner cavity of the switching bin and is also slidingly connected with the sliding seat.
Further, a limiting ring is fixedly connected in the pump barrel between the sliding seat and the conversion bin.
Further, the pump cylinder is arranged at one position on each side plate of the conversion bin.
Further, the outer wall of each pump cylinder is fixedly connected with a spiral magnetic induction wire, the sliding seat is made of a permanent magnet material, the outer wall of the pump cylinder is fixedly connected with a waterproof cover, the waterproof cover covers the spiral magnetic induction wires in the waterproof cover, and each spiral magnetic induction wire is electrically connected with the heating plate.
Further, the test tube rack comprises a mounting frame and placing rings, the mounting frame is fixedly connected to the inner cavity of the box body, two groups of placing rings are arranged in the mounting frame front and back, each group of placing rings are transversely and uniformly provided with a plurality of placing rings, two adjacent placing rings are fixedly connected into an integrated structure through connecting plates, and the placing rings on the side are fixedly connected into an integrated structure through connecting plates with the inner wall of the mounting frame.
Further, the placing ring is fixedly connected with a rubber sleeve, and the placing ring further comprises a reagent tube, and the reagent tube is in interference fit with the rubber sleeve.
The beneficial effects of the invention are as follows:
1. in the using process, the reagent tube containing biological reagent is inserted on the test tube rack, then water bath heating water is contained in the box body, the water enters the cover body through the communication hole, and the carrying device is driven by the motor to work, so that the water is carried into the box body from the cover body, the water circulation is realized, and the water is heated when passing through the heating cylinder, so that the water bath heating is more uniform and efficient.
2. Through the setting of being responsible for and accessory pipe, water enters into the person in charge through the back flow and then spouts from each accessory pipe for in the spun hot water more even flows the box body, realizes the even distribution of hot water promptly in the in-process that hot water got into to make the water temperature in the box body more even, the reagent pipe inserts in placing the ring, carries out the fixed placement of reagent pipe through the rubber sleeve, convenient to use.
3. The motor during operation drives the drive wheel and rotates, the drive wheel passes through the belt and drives the drive wheel and rotate, thereby the pivot, change storehouse and the integrative structure of pump barrel rotate, the pump barrel is at pivoted in-process, because the gravity of slide exists, when each pump barrel is located the top of change storehouse, the slide slides down and is close to the change storehouse, when each pump barrel is located the below of change storehouse, the slide slides down and keeps away from the change storehouse, when change storehouse rotates promptly, the slide slides reciprocally in the pump barrel, when the pump barrel kept away from the change storehouse, the water in the cover body enters into the pump barrel through the water inlet, when the pump barrel is close to the change storehouse, the water in the pump barrel enters into the change storehouse through the delivery port, the water in the change storehouse enters into the stay tube through water pipe and outlet, and in proper order through fluid-discharge tube, heating cylinder and back flow pipe entering into the box body.
4. The slide is made of permanent magnet materials, so that the magnetic field of the slide is cut by the spiral magnetic induction wire in the reciprocating motion process of the slide, current is generated on the spiral magnetic induction wire and is conveyed to the heating plate, the heating plate can work smoothly, and the complexity and the manufacturing cost of the device are effectively reduced because the heating plate is additionally provided with a new power source.
Drawings
In order to more clearly illustrate the technical solutions of the present invention, the drawings that are needed in the description of the specific embodiments will be briefly described below, it being obvious that the drawings in the following description are only some examples of the present invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1: the invention relates to a longitudinal schematic diagram of a water bath heating type biological reagent reaction box;
fig. 2: a partial enlarged view at a shown in fig. 1;
fig. 3: the invention relates to a transverse schematic diagram of a water bath heating type biological reagent reaction box;
fig. 4: a partial enlarged view at B shown in fig. 3;
fig. 5: the structure schematic diagram of the test tube rack is provided;
fig. 6: the invention relates to a partial schematic diagram of a carrying device.
The reference numerals are as follows:
1-box body, 2-heating cylinder, 3-cover body, 4-handling device, 5-motor, 6-test tube rack, 7-fixed cover, 8-heating plate, 9-back flow, 10-communication hole, 11-fluid-discharge tube, 12-mount pad, 13-auxiliary tube, 14-main tube, 15-conversion bin, 16-retention cylinder, 17-pump cylinder, 18-water tube, 19-outlet, 20-pivot, 21-drive wheel, 22-drive wheel, 23-belt, 24-water inlet, 25-first check valve, 26-water outlet, 27-second check valve, 28-slide, 29-stop collar, 30-spiral magnetic induction line, 31-waterproof cover, 32-mounting frame, 33-placement ring, 34-connecting plate, 35-rubber sleeve, 36-reagent tube.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
As shown in fig. 1 to 6, a water bath heating type biological reagent reaction box comprises a box body 1, a heating cylinder 2, a cover body 3, a carrying device 4 and a motor 5; the box body 1 is a cuboid cavity structure with an open top, a test tube rack 6 is arranged in the box body 1, a heating cylinder 2 is fixedly arranged on the outer wall of a rear side plate of the box body 1 through a fixing sleeve 7, a cylindrical heating plate 8 is fixedly connected in the heating cylinder 2, a return pipe 9 is fixedly connected to the right end of the heating cylinder 2, the head of the return pipe 9 is connected with the upper portion of a right side plate of the box body 1, a cover body 3 is fixedly connected to the outer wall of a left side plate of the box body 1, a plurality of communication holes 10 are longitudinally and uniformly arranged at the position, corresponding to the lower portion of an inner cavity of the cover body 3, of the left side plate of the box body 1, the communication holes 10 conduct the inner cavity of the box body 1 and the cover body 3, a carrying device 4 is arranged in the cover body 3, an outlet of the carrying device 4 is connected with the left end of the heating cylinder 2 through a liquid discharge tube 11, a mounting seat 12 is fixedly connected to the outer wall of a front side plate of the box body 1, a motor 5 is fixedly connected to the mounting seat 12, and the motor 5 drives the carrying device 4 to work.
Preferably, the upper part of the right side plate of the box body 1 is longitudinally and uniformly fixedly connected with auxiliary pipes 13, the right end of each auxiliary pipe 13 is integrally fixedly connected with a main pipe 14, and the return pipe 9 is connected between the right end of the heating cylinder 2 and the rear end of the main pipe 14.
Preferably, the handling device 4 comprises a transfer magazine 15, a retention cylinder 16 and a pump cylinder 17; the conversion bin 15 is arranged in the cover body 3, the conversion bin 15 is of a cuboid cavity structure, the rear end of the conversion bin 15 is fixedly connected with a water pipe 18 communicated with the inner cavity of the conversion bin 15, the water pipe 18 is rotationally connected with the rear side plate of the cover body 3, water pipes 18 outside the cover body 3 are densely provided with water outlets 19, the front side plate of the conversion bin 15 is fixedly connected with a rotating shaft 20, the rotating shaft 20 is rotationally connected with the front side plate of the cover body 3, the head part of the rotating shaft 20 is fixedly connected with a driving wheel 21, the output shaft of the motor 5 is fixedly connected with a driving wheel 22, the driving wheel 22 is linked with the driving wheel 21 through a belt 23, the retention cylinder 16 is fixedly connected with the outer wall of the rear side plate of the cover body 3 and covers the water pipe 18 therein, the both ends of fluid-discharge tube 11 are connected with keeping somewhere section of thick bamboo 16 and heating cylinder 2 respectively, pump cylinder 17 rigid coupling is at the outer wall of conversion storehouse 15, the position circumference that pump cylinder 17 is close to conversion storehouse 15 evenly rigid coupling has water inlet 24, be equipped with first check valve 25 in the water inlet 24, the direction that first check valve 25 allowed the fluid to pass through is the directional pump cylinder 17 inner chamber of cover body 3 inner chamber, the rigid coupling has delivery port 26 on the conversion storehouse 15 curb plate in the region that pump cylinder 17 covers, be equipped with second check valve 27 in the delivery port 26, the direction that second check valve 27 allowed the fluid to pass through is the directional conversion storehouse 15 of pump cylinder 17, still sealed sliding connection has slide 28 in the pump cylinder 17.
Preferably, a limiting ring 29 is fixedly connected in the pump barrel 17 between the sliding seat 28 and the conversion bin 15.
Preferably, the pump cylinder 17 is provided at one place on each side plate of the switching magazine 15.
Preferably, the outer wall of each pump cylinder 17 is fixedly connected with a spiral magnetic induction wire 30, the sliding seat 28 is made of a permanent magnet material, the outer wall of the pump cylinder 17 is fixedly connected with a waterproof cover 31, the waterproof cover 31 covers the spiral magnetic induction wires 30 inside, and each spiral magnetic induction wire 30 is electrically connected with the heating plate 8.
Preferably, the test tube rack 6 comprises a mounting frame 32 and placing rings 33, wherein the mounting frame 32 is fixedly connected to the inner cavity of the box body 1, two groups of placing rings 33 are arranged in the mounting frame 32 front and back, each group of placing rings 33 is transversely and uniformly provided with a plurality of placing rings, two adjacent placing rings 33 are fixedly connected into an integral structure through a connecting plate 34, and the placing rings 33 at the side are fixedly connected into an integral structure with the inner wall of the mounting frame 32 through the connecting plate 34.
Preferably, the rubber sleeve 35 is fixedly connected in the placement ring 33, and the kit further comprises a reagent tube 36, and the reagent tube 36 is in interference fit in the rubber sleeve 35.
One embodiment of the invention is as follows:
in the using process of the invention, the reagent tube 36 containing biological reagent is inserted on the test tube rack 6, then water bath heating water is contained in the box body 1, the water enters the cover body 3 through the communication hole 10, and the carrying device 4 is driven by the motor 5 to work, so that the water is carried into the box body 1 from the cover body 3, the water circulation is realized, the water is heated when passing through the position of the heating cylinder 2, and the water bath heating is more uniform and efficient.
Through the setting of being responsible for 14 and accessory pipe 13, water enters into to be responsible for 14 through back flow 9 then from each accessory pipe 13 blowout for the more even flow of spun hot water is in box body 1, realizes the even distribution of hot water promptly in the in-process that hot water got into, thereby makes the temperature of the temperature in the box body 1 more even, and reagent pipe 36 inserts into placing in the ring 33, carries out the fixed placement of reagent pipe 36 through rubber sleeve 35, convenient to use.
The motor 5 drives the driving wheel 22 to rotate when working, the driving wheel 22 drives the driving wheel 21 to rotate through the belt 23, so that the rotating shaft 20, the conversion bin 15 and the pump cylinder 17 rotate in an integrated structure, the pump cylinder 17 rotates, due to the gravity of the sliding seat 28, when each pump cylinder 17 is positioned above the conversion bin 15, the sliding seat 28 slides down and is close to the conversion bin 15, when each pump cylinder 17 is positioned below the conversion bin 15, the sliding seat 28 slides back and forth in the pump cylinder 17 when the conversion bin 15 rotates, namely, when the pump cylinder 17 is far away from the conversion bin 15, water in the cover body 3 enters the pump cylinder 17 through the water inlet 24, when the pump cylinder 17 is close to the conversion bin 15, water in the pump cylinder 17 enters the conversion bin 15 through the water outlet 26, water in the conversion bin 15 enters the retention cylinder 16 through the water pipe 18 and the water outlet 19, and sequentially enters the box body 1 through the liquid discharge pipe 11, the heating cylinders 2 and 9.
The slide 28 is made of a permanent magnet material, so that the spiral magnetic induction wire 30 cuts the magnetic field of the slide 28 in the reciprocating motion process of the slide 28, and thus, current is generated on the spiral magnetic induction wire 30 and is transmitted to the heating plate 8, so that the heating plate 8 can work smoothly, and the complexity and manufacturing cost of the device are effectively reduced because the heating plate 8 is additionally provided with a new power source.
The preferred embodiments of the invention disclosed above are intended only to assist in the explanation of the invention. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise form disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best understand and utilize the invention. The invention is limited only by the claims and the full scope and equivalents thereof.
Claims (7)
1. A water bath heating type biological reagent reaction box is characterized in that: comprises a box body, a heating cylinder, a cover body, a carrying device and a motor; the box body is of a cuboid cavity structure with an open top, a test tube rack is arranged in the box body, the heating cylinder is fixedly arranged on the outer wall of the rear side plate of the box body through a fixing sleeve, a cylindrical heating plate is fixedly connected in the heating cylinder, a return pipe is fixedly connected to the right end of the heating cylinder, the head of the return pipe is connected with the upper part of the right side plate of the box body, the box body is fixedly connected to the outer wall of the left side plate of the box body, a plurality of communication holes are longitudinally and uniformly arranged at the position, corresponding to the lower part of the cavity in the box body, of the left side plate of the box body, the communication holes conduct the box body with the inner cavity of the box body, the carrying device is arranged in the box body, the outlet of the carrying device is connected with the left end of the heating cylinder through a liquid discharge tube, an installation seat is fixedly connected to the outer wall of the front side plate of the box body, and the motor is fixedly connected to the installation seat, and the motor drives the carrying device to work;
the carrying device comprises a conversion bin, an indwelling cylinder and a pump cylinder; the switching bin is arranged in the cover body, the switching bin is of a cuboid cavity structure, the rear end of the switching bin is fixedly connected with a water pipe communicated with the inner cavity of the switching bin, the water pipe is rotationally connected with the rear side plate of the cover body, a water outlet is densely distributed on the water pipe outside the cover body, a rotating shaft is fixedly connected on the front side plate of the switching bin, the rotating shaft is rotationally connected with the front side plate of the cover body, a driving wheel is fixedly connected on the head of the rotating shaft, a driving wheel is fixedly connected on the output shaft of the motor, the driving wheel is linked with the driving wheel through a belt, the retaining cylinder is fixedly connected on the outer wall of the rear side plate of the cover body and covers the water pipe in the driving wheel, two ends of the liquid discharge pipe are respectively connected with the retaining cylinder and the heating cylinder, the pump cylinder is fixedly connected on the outer wall of the switching bin, a water inlet is uniformly fixedly connected on the circumference of the position of the pump cylinder close to the switching bin, a first one-way valve is arranged in the water inlet, the direction allowing fluid to pass through the inner cavity of the cover body is pointed towards the inner cavity of the pump cylinder, a water outlet is fixedly connected on the switching bin side plate of the cover body, a second one-way valve is arranged in the water outlet, the direction allowing fluid to pass through the pump cylinder is pointed towards the inner cavity of the switching bin and is also slidingly connected with the sliding seat.
2. The water bath heating type biological reagent reaction kit according to claim 1, wherein: the upper part of the right side plate of the box body is longitudinally and uniformly fixedly connected with auxiliary pipes, the right end of each auxiliary pipe is integrally fixedly connected with a main pipe, and the return pipe is connected between the right end of the heating cylinder and the rear end of the main pipe.
3. The water bath heating type biological reagent reaction kit according to claim 2, wherein: and a limiting ring is fixedly connected in the pump barrel between the sliding seat and the conversion bin.
4. A water bath heating type biological reagent reaction kit according to claim 3, wherein: the pump cylinder is arranged at one position on each side plate of the conversion bin.
5. The water bath heating type biological reagent reaction kit according to claim 4, wherein: the outer wall of each pump cylinder is fixedly connected with a spiral magnetic induction wire, the sliding seat is made of a permanent magnet material, the outer wall of the pump cylinder is fixedly connected with a waterproof cover, the waterproof cover covers the spiral magnetic induction wire inside the waterproof cover, and each spiral magnetic induction wire is electrically connected with the heating plate.
6. The water bath heating type biological reagent reaction kit according to claim 1, wherein: the test tube rack comprises a mounting frame and placing rings, wherein the mounting frame is fixedly connected to the inner cavity of the box body, two groups of placing rings are arranged in the mounting frame front and back, each group of placing rings are transversely and uniformly provided with a plurality of placing rings, two adjacent placing rings are fixedly connected into an integrated structure through connecting plates, and the placing rings on the side are fixedly connected into an integrated structure through connecting plates with the inner wall of the mounting frame.
7. The water bath heating type biological reagent reaction kit according to claim 6, wherein: the placing ring is fixedly connected with a rubber sleeve and further comprises a reagent tube, and the reagent tube is in interference fit with the rubber sleeve.
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CN202110036392.7A CN112881677B (en) | 2021-01-12 | 2021-01-12 | Water bath heating type biological reagent reaction box |
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CN202110036392.7A CN112881677B (en) | 2021-01-12 | 2021-01-12 | Water bath heating type biological reagent reaction box |
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CN112881677B true CN112881677B (en) | 2024-02-02 |
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