CN112852753A - Novel staphylococcus aureus bacteriophage and composition and application thereof - Google Patents

Abstract

The invention relates to the field of biology, in particular to a novel staphylococcus aureus bacteriophage and a composition and application thereof, and provides a 4-strain staphylococcus aureus bacteriophage, namely a tailed bacteriophage BP-13 with a preservation number of CCTCC NO: m2015142; staphylococcus aureus BP-13A with a preservation number of CCTCC M2016535; the short-tail phage BP-14 has a preservation number of CCTCC NO: m2015143; the brachyury phage AHJD-like phage belongs to BP-39, and has a preservation number of CCTCC NO: m2015144. The 4 strains of bacteriophage of the invention are strict virulent bacteriophage, can effectively kill various staphylococcus aureus such as MRSA, MSSA, BORSA and the like, has wider host range, but has no toxic action on normal microbial flora, and the DNA of the 4 strains of bacteriophage can not code virulence genes. Therefore, the antibacterial agent can be used for preventing or treating human and livestock bacterial infection caused by staphylococcus aureus, provides excellent strain resources for developing novel antibacterial preparations, and has good application and development prospects. The host range and the bacteriostatic efficiency of the cocktail mixture are further greatly improved.

Description

Novel staphylococcus aureus bacteriophage and composition and application thereof

The application is a divisional application of an invention patent application with the application number of CN201710048705.4, the application date of 2017, 01, 22 and the name of 'novel staphylococcus aureus bacteriophage and a composition and application thereof'.

Technical Field

The invention belongs to the technical field of microorganisms, and particularly relates to a novel staphylococcus aureus bacteriophage, a composition thereof, a preparation method and an application thereof.

Background

Staphylococcus aureus (Staphylococcus aureus) is an important zoonotic pathogen, widely exists in nature, has wide infection range and strong adaptability, can cause various diseases such as wound infection, endocarditis, osteomyelitis, toxic shock syndrome and the like, and has a mortality rate ranging from 11% to 48%. Methicillin-susceptible staphylococcus aureus (MSSA) can be killed by penicillin and methicillin, but nowadays the majority of staphylococcus aureus in the united states is resistant to penicillin, methicillin, tetracycline and erythromycin, of which methicillin-resistant staphylococcus aureus (MRSA) is the most prevalent pathogenic bacterium in hospitals and is resistant to all β -lactam antibiotics except for the novel cephalosporin. In addition, intermediate-level (4-8. mu.g/mL) resistant Staphylococcus aureus, the famous marginal-type anti-methicillin Staphylococcus aureus (BORSA), appeared by the end of the 90 s of the 20 th century. Clinical studies show that the rate of incapability of treatment due to drug-resistant staphylococcus aureus infection is rapidly increased in recent years, so that a large number of patients die every year, the treatment of staphylococcus aureus infection is increasingly difficult, and a novel therapeutic drug capable of effectively inhibiting staphylococcus aureus infection is urgently needed by human beings.

Bacteriophage is a virus that kills specific bacteria by binding to specific sites on the surface of bacterial cells, and is widely present on earth. Since the 20 th 30 th century, pasteur laboratories (paris) proposed phage therapy for the treatment of bacterial infections, more and more studies have demonstrated that phages have high antibacterial activity and specificity, can control drug-resistant bacteria and prevent damaging microflora. Compared with antibiotic treatment, it has very low side effect, is more rapid and effective, does not inhibit the body's natural immunity or cause allergy, and has no infectivity and toxicity to human or other mammals.

However, phages also have their disadvantages in the sterilization process. First, the specificity of the phage host is strong, the host spectrum of the treatment is relatively narrow, and a single phage is often very difficult to meet the needs of clinical treatment, and in addition, related studies show that a single phage is in contact with bacteria for a long time, and the bacteria can resist the invasion of the phage through various ways such as adsorption inhibition, abortion infection and establishment of lysogenic state (Harper DR, et al. bacteriophagy therapy: reactive and clinical connected means in the multi-drug-resistance operation. future Microbiol, 2012, 7 (7): 797-. The cocktail preparation composed of multiple phages can not only greatly expand the host range of the phages, but also reduce the drug resistance of bacteria to the phages.

Currently, most of the Staphylococcus aureus phage literature is limited to the study of the bactericidal capacity of a single phage (Wang, Z.F., et al, SLPW: A Virus Bacteriophage Targeting Methhicillin-Resistant Staphylococcus aureus In vitro and In vivo. frontiers In Microbiology, 2016.7: p.10., Jia, H.Y., et al, charaterization and complex genome sequencing analysis of Staphylococcus aureus genome 01.Virus Genes, 2015.50 (2): p.345-348. university of south of the Yangtze, a phage of Staphylococcus aureus and its application, application No. CN201110380587), while the study of the properties of cocktail consisting of several phages is reported.

Disclosure of Invention

In view of the above technical state, the present invention provides novel staphylococcus aureus phages and their compositions that can lyse staphylococcus aureus, which have a strong ability to lyse staphylococcus aureus MRSA. The staphylococcus aureus bacteriophage of the invention is as follows:

BP-13(Podoviridae sp. BP-13), CCTCC NO: m2015142, the preservation unit is China center for type culture Collection, the preservation time is 2015, 03 and 23 days;

staphylococcus aureus BP-13A (Staphylococcus aureus phase BP-13A), with a preservation number of CCTCC M2016535, wherein the preservation unit is China center for type culture Collection, and the preservation time is 2016, 9 and 28 days;

BP-14(Podoviridae sp. BP-14), CCTCC NO: m2015143, the preservation unit is China center for type culture Collection, and the preservation time is 2015, 03 and 23 days; or

The brachyury phage AHJD-like phage genus BP-39(Podoviridae picovirinae Ahjdrikikevir BP-39) has a collection number of CCTCC NO: the M2015144 preservation unit is China center for type culture Collection, and the preservation time is 2015, 03 and 23 days.

In one embodiment of the present invention, the bacteriophage BP-13(Podoviridae sp. BP-13) has a morphological structure consisting of an equiaxed capsid and a contractile short tail, and has a potency of 2.1 × 10 by culturing at pH5 to 9, at 4 to 37 ℃, and at an MOI of 0.01 for 6 hours¹⁰pfu/mL；

In one embodiment of the present invention, the Staphylococcus aureus BP-13A (Staphylococcus aureus phase BP-13A) has a morphological structure consisting of an equiaxed capsid, a contractible long tail and six short spines at the tail end, is tolerant at pH5 to pH9 at 4 to 37 ℃, and has a titer of 6.8 × 10 by culturing for 6 hours at an MOI of 0.1⁸pfu/mL；

In one embodiment of the present invention, the bacteriophage brachyury BP-14(Podoviridae sp. BP-14) has a morphological structure consisting of an equiaxed capsid and a contractile brachyury, and has a potency of 5 × 10 by culturing at pH5 to pH11 at 4 to 37 ℃ for 6 hours with an MOI of 0.001¹¹pfu/mL；

In the present invention, as one embodiment, the brachyury phage AHJD-like phage genus BP-39(Podoviridae picovirinae Ahjdlikevirus BP-39) has an equiaxed capsid and a contractility of short lengthThe tail composition is cultured for 6h under the conditions of pH 3-9, tolerance at 4-37 ℃, MOI of 0.01, and titer of 2.0 × 10⁹pfu/mL。

In the present invention, as one embodiment, the bacteriophage brachyury BP-13(Podoviridae sp. BP-13) has a nucleotide sequence shown by SEQ ID No. 1;

in the present invention, as one embodiment, the Staphylococcus aureus BP-13A (Staphylococcus aureus phase BP-13A) has a nucleotide sequence shown in SEQ ID No. 2;

in the present invention, as one embodiment, the bacteriophage brachyury BP-14(Podoviridae sp. BP-14) has a nucleotide sequence shown by SEQ ID No. 3;

in the present invention, as one embodiment, the brachyury phage AHJD-like phage genus BP-39(Podoviridae picovirinae Ahjdlikevirus BP-39) has the nucleotide sequence shown in SEQ ID No. 4.

Biological characteristics of the brachyury BP-13: by taking multi-drug-resistant staphylococcus aureus J1 as a host bacterium and culturing at 37 ℃ overnight, the BP-13 can form a plaque with the average diameter of 2-3 mm; the morphology of the BP-13 phage was observed under an electron microscope and was found to have a head structure in the form of a regular polyhedron and a shorter tail, with a head diameter of about 150nm and a tail length of about 10nm (FIG. 1-A). The size of the whole genome sequence of the BP-13 phage is 18178BP, and the whole genome sequence is double-stranded linear DNA. The genome sequence of the BP-13 gene belongs to the Podoviridae (Podoviridae) through Blast alignment, and the genome sequence analysis shows that the whole genome of the BP-13 phage has avirulent genes or undesirable genes.

Biological characteristics of Staphylococcus aureus BP-13A: by taking multi-drug-resistant staphylococcus aureus J1 as a host bacterium and carrying out overnight culture at 37 ℃, the BP-13A can form a plaque with the average diameter of 2-3 mm; the BP-13A phage morphology, observed under an electron microscope, had a regular polyhedral head structure and a shorter tail, with a head diameter of about 100nm and a tail length of about 10nm (FIG. 1-B). The whole genome sequence of the BP-13A phage is 136563BP in size, and is double-stranded linear DNA. BP-13A was found to belong to Myoviridae (Myoviridae) by Blast alignment of its genomic sequence. Genome sequence analysis shows that the whole genome of the BP-13A phage has avirulence genes or adverse genes.

Biological characteristics of the brachyury phage BP-14: by taking multi-drug-resistant staphylococcus aureus J1 as a host bacterium and carrying out overnight culture at 37 ℃, the BP-14 can form a plaque with the average diameter of 2-3 mm; the BP-14 phage morphology, observed under an electron microscope, had a regular polyhedral head structure and a shorter tail, with a head diameter of about 150nm and a tail length of about 10nm (FIG. 1-C). The size of the whole genome sequence of the BP-14 phage is 18137BP, and the whole genome sequence is double-stranded linear DNA. BP-14 was found to belong to the Podoviridae (Podoviridae) by Blast alignment of its genomic sequence and was not identical to the genomic sequence of the known phage genome at NCBI, indicating that the phage was a new species of phage; genome sequence analysis shows that the whole genome of the BP-14 phage has avirulence genes or adverse genes.

Biological characteristics of the brachyury phage AHJD-like phage genus BP-39: by taking multi-drug-resistant staphylococcus aureus J1 as a host bacterium and carrying out overnight culture at 37 ℃, the BP-39 can form a plaque with the average diameter of 2-3 mm; the morphology of the BP-39 phage was observed under an electron microscope and was found to have a head structure in the form of a regular polyhedron with a shorter tail, a head diameter of about 20nm and a tail length of about 20nm (FIG. 1-D). The whole genome sequence of the BP-39 bacteriophage is 17641BP in size and is double-stranded linear DNA. BP-39 was found to belong to the family of the brachyphagidae (Podoviridae) by aligning its genomic sequence with Blast. Genome sequence analysis shows that the whole genome of the BP-39 bacteriophage has no virulence genes or adverse genes.

The present invention still further provides a composition of Staphylococcus aureus phage, which, as one of the embodiments, contains three or four combinations of the brachyury phage BP-13(Podoviridae sp.BP-13), Staphylococcus aureus BP-13A (Staphylococcus aureus phage BP-13A), brachyury phage BP-14(Podoviridae sp.BP-14), and the brachyury phage AHJD-like phage BP-39(Podoviridae Ahjdikevir BP-39).

As an embodiment, the three or four compositions of the present invention may be any three or all four combinations of the aforementioned phages, i.e., bacteriophage B-13 (Podoviridae sp. BP-13), Staphylococcus aureus BP-13A (Staphylococcus aureus BP13-A), bacteriophage BP-14(Podoviridae sp. BP-14) and bacteriophage AHJD-like phage BP-39, as an exemplary illustration, such as the combination of BP-13, BP-13A and BP-14, the combination of BP-13, BP-13A and BP-39, the combination of BP-13, BP-14 and BP-39, the combination of BP-13A, BP-14 and BP-39 and the combination of BP-13, BP-13A, BP-14 and BP-39.

The amount of each phage in the composition of the present invention can be determined by those skilled in the art based on the present disclosure, specific application environment and general knowledge in the art, and as one embodiment, the ratio of BP-13, BP-13A and BP-14 is 1: 1, the ratio of BP-13, BP-13A and BP-39 is 1: 1, the ratio of BP-13, BP-14 and BP-39 is 1: 1, the ratio of BP-13A, BP-14 and BP-39 is 1: 1, and the ratio of BP-13, BP-13A, BP-14 and BP-39 is 1: 1, in terms of the titer ratio of each phage contained in a unit volume.

As one embodiment, the present invention also provides a reagent or kit comprising the above phage or phage composition. The reagents or kits of the invention comprising the above-described phage or phage composition can be prepared by one skilled in the art based on the present disclosure and general knowledge in the art.

The invention provides application of the phage, the phage composition or the reagent or the kit containing the phage or the phage composition in resisting human staphylococcus aureus (MRSA, MSSA, BORSA) or animal staphylococcus aureus.

As one embodiment, the phage has a total effective working titer of ≧ 1X 10 when bacterial lysis is performed whether using a single phage or a combination of three or four phages⁷pfu/mL。

As one embodiment, the invention also provides the phage, the phage composition or the reagent or kit containing the phage or the phage composition for preparing medicines for treating human and livestock diseases such as scald infection caused by staphylococcus aureus and cow mastitis.

The phages BP-13, BP-13A, BP-14 and BP-39 in the present invention were isolated from Montreal, Canada sewage treatment plants.

As one embodiment, the method comprises:

the method comprises the steps of filtering source samples of phages BP-13, BP-13A, BP-14 and BP-39 collected from Montreal sewage treatment plants in Canada by double-layer filter paper, centrifuging at low speed and normal temperature, and filtering supernate by using a filter membrane.

Separation of phage: and respectively taking the filtered supernatants, adding the filtered supernatants into a TSB culture medium, simultaneously adding a phage host bacteria log-phase bacterial liquid, culturing at 37 ℃, centrifuging the culture, and filtering the supernatant by using a filter membrane for later use. And adding the log-phase bacterial liquid of the phage host bacteria into the semi-solid TSB culture medium, uniformly mixing, pouring onto a TSA flat plate, and preparing into a double-layer flat plate containing the host bacteria. Dripping the filtered supernatant onto the coagulated double-layer plate, air-drying under aseptic condition, and culturing at 37 deg.C for 16h to obtain bacteriophage spot.

And (3) purifying the phage: picking bacteriophage spot spots into SM buffer solution, shaking, performing gradient dilution, adding the dilution solution into logarithmic phase host bacteria, mixing uniformly, standing, adding semi-solid TSB culture medium, immediately pouring onto TSA plate, shaking uniformly, standing for solidification, and culturing in 37 deg.C incubator to obtain double-layer plate containing single bacteriophage spot. Picking up single plaques into SM buffer solution, purifying for many times according to the method, finally picking up single plaques with consistent shape and size on a plaque forming plate, placing the single plaques in a TSB culture medium containing log-phase host bacterium liquid, and shaking at 37 ℃. And centrifuging the culture, and filtering the supernatant with a filter membrane to obtain the purified phage solution.

Experiments prove that: the phage composition consisting of the staphylococcus aureus phages BP-13, BP-13A, BP-14 and BP-39 can achieve the cracking rate of 97 percent on 135 strains of humanized staphylococcus aureus and 100 percent on 44 strains of bovine staphylococcus aureus.

Compared with the prior art, the bacteriophage BP-13, BP-13A, BP-14 and BP-39 have the advantages that: are strictly virulent bacteriophages and are effective in killing bacteria including staphylococcus aureus; the compound has better lysis capacity to host bacteria under lower concentration; no toxic action on normal microbial flora; the DNA of the gene can not code virulence genes; in particular, the present invention does not subject the test phage to any genetic modification. Therefore, the 4-strain phages BP-13, BP-13A, BP-14 and BP-39 can treat or prevent bacterial infection caused by staphylococcus aureus, provide excellent strain resources for developing novel antibacterial preparations, and have good application and development prospects.

Drawings

FIG. 1: morphological characteristics under transmission electron microscope of the 4 phage strains obtained in example 1.

The preservation unit of the brachyury phage BP-13(Podoviridae sp.BP-13) is China center for type culture Collection, and the address is Wuhan university, Wuchang Lojia mountain, Wuhan, Hubei province, post code 430072; the preservation date is 2015, 3 and 23 days, and the preservation number is CCTCC NO: m2015142;

the preservation unit of Staphylococcus aureus BP-13A (Staphylococcus aureus sage BP-13A) is China center for type culture Collection, and the address is Wuhan university, postcode 430072, at Wuchang Lodojia mountain Wuhan university, Wuhan city, Hubei province; the preservation date is 2016, 9 and 28 months, and the preservation number is CCTCC M2016535;

the preservation unit of the brachyury phage BP-14(Podoviridae sp.BP-14) is China center for type culture Collection, and the address is Wuhan university, Wuchang Lojia mountain, Wuhan, Hubei province, post code 430072; the preservation date is 2015, 3 and 23 days, and the preservation number is CCTCC NO: m2015143;

the short-tail phage AHJD-like phage BP-39(Podoviridae picovirinae Ahjdlikevixus BP-39) has a preservation unit of China center for type culture Collection, and has an address of Wuhan university, Wuchan Lojia mountain, Wuhan, Hubei, and a post code of 430072; the preservation date is 2015, 3 and 23 days, and the preservation number is CCTCC NO: m2015144.

Detailed Description

The following examples serve to further illustrate the invention, but do not in any way limit the effective scope of the invention.

In the following examples, the following examples are given,

the formula of the TSB liquid culture medium is as follows: 15g of tryptone, 5g of soybean peptone, 5g of sodium chloride and 1000mL of distilled water;

the formula of the TSA solid culture medium is as follows: 15g of tryptone, 5g of soybean peptone, 5g of sodium chloride, 15g of agar and 1000mL of distilled water;

the formula of the TSB semisolid agar culture medium is as follows: 15g of tryptone, 5g of soybean peptone, 5g of sodium chloride, 7g of agar and 1000mL of distilled water;

the SM liquid formula is as follows: 8.5g of sodium chloride, 2g of magnesium sulfate, 50mL of 1mol/L TrisHCl, 0.25g of gelatin and 1000mL of distilled water.

Example 1: separation preparation and purification culture of bacteriophage

The source samples of the brachyury bacteriophage BP-13, the staphylococcus aureus BP-13A, the brachyury bacteriophage BP-14 and the brachyury bacteriophage AHJD-like bacteriophage BP-39 are collected in a Canada Montreal sewage treatment plant, filtered by double-layer filter paper, centrifuged at low speed and normal temperature, and the supernatant is filtered by a filter membrane of 0.22 mu m.

Separation of phage: and taking 10mL of filtered supernatant, adding the filtered supernatant into 10mL of 2-time TSB culture medium, adding 1mL of phage host bacteria log phase bacteria liquid, placing the mixture at 37 ℃ for culturing for 16h, taking the culture, centrifuging the culture for 10min at 8000rpm, and filtering the supernatant by using a 0.22-micron filter membrane for later use. And (3) adding 0.5mL of phage host bacteria log-phase bacterial liquid into 5mL of semi-solid TSB culture medium at 40 ℃, uniformly mixing, pouring onto a TSA plate, and preparing into a double-layer plate containing host bacteria. Dripping 10 μ l of the filtered supernatant onto the coagulated double-layer plate, air-drying under aseptic condition, and culturing at 37 deg.C for 16h to form phage spot.

And (3) purifying the phage: picking bacteriophage spot to 1mL SM buffer solution, shaking for 1min, performing 10-fold gradient dilution, and taking 10²，10⁴And 10⁶Adding 0.5mL of logarithmic phase host bacteria into the diluted solution respectively, mixing uniformly, standing for 15min, adding 5mL of semi-solid TSB at 40 deg.C, and culturingAnd (3) culturing the medium, immediately pouring the medium on a TSA plate, shaking the medium evenly and flatly for 5min, observing the medium after the medium is solidified and culturing the medium in an incubator at 37 ℃ for 16h to obtain a double-layer plate containing single plaques. Picking up single plaques into 1mL of SM buffer solution, purifying for at least 3 times according to the method, finally picking up single plaques with consistent shape and size on plaque forming plates, placing the single plaques in 50mL of TSB culture medium containing 1mL of log phase host bacterium liquid, and shaking at 37 ℃ and 180rpm for 16 h. Centrifuging the culture at 8000rpm for 10min, filtering the supernatant with 0.22 μm filter membrane to obtain purified phage solution, and respectively obtaining brachyury phage BP-13(Podoviridae sp. BP-13) with preservation number of CCTCC NO: m2015142, Staphylococcus aureus BP-13A (Staphylococcus aureus BP-13A), with a preservation number of CCTCC No: m2016535, bacteriophage B-14 (Podoviridae sp. BP-14), accession number CCTCC NO: m2015143, or a brachyury phage AHJD-like phage genus BP-39(Podoviridae picovirinae Ahjdlikevirus BP-39), having a accession number of CCTCC NO: m2015144.

Example 2: electron microscopy of bacteriophages

Each phage culture supernatant obtained in example 1 was used for electron microscopy: dropping 20 μ L of sample on a copper mesh, naturally precipitating for 15min, absorbing the excessive liquid from the side with filter paper, adding 1 drop of 2% phosphotungstic acid (PTA) on the copper mesh, dyeing for 10min, absorbing the dye solution from the side with filter paper, drying, and observing with an electron microscope: as a result, as shown in FIG. 1, the BP-13 phage morphology was found to have a head structure in the form of a regular polyhedron and a shorter tail, with a head diameter of about 150nm and a tail length of about 10nm (FIG. 1-A); the BP-13A phage is found to be in a shape of a regular polyhedron with a head structure and a shorter tail, wherein the diameter of the head is about 100nm, the length of the tail is about 10nm, and the tail end of the tail is provided with six short spines (figure 1-B); the BP-14 phage morphology was found to have a regular polyhedral head structure and a shorter tail, with a head diameter of about 150nm and a tail length of about 10nm (FIG. 1-C); the BP-39 phage morphology was found to have a head structure in the form of a regular polyhedron with a shorter tail, a head diameter of about 20nm and a tail length of about 20nm (FIG. 1-D).

Example 3: extraction and sequencing of phage genome

100mL of each phage prepared in example 1 was added with DNaseI and RNaseA at a final concentration of 1. mu.g/mL, incubated at 37 ℃ for 60min, dissolved in 5.84g of NaCl at a final concentration of 1mol/L, and placed in an ice bath for 1 h. The supernatant was transferred to a new centrifuge tube by centrifugation at 11000rpm for 10min at 4 ℃. Solid PEG8000 (10% final concentration, i.e. 10g in 100 mL) was added and, after complete dissolution, the ice bath was incubated for at least 1 h. Centrifuging at 11000rpm for 20min at 4 deg.C, and resuspending the precipitate with small amount of SM solution. Adding chloroform isoamyl alcohol with the same volume for extraction, gently shaking for 30s, centrifuging at 8000rpm for 1min, sucking supernatant, and repeatedly extracting until the supernatant is clear. Adding DNase I and RNase A again to the final concentration of 1 mu g/mL, and reacting at 37 ℃ for 30-60 min. EDTA was added to a final concentration of 20mmol/L (i.e., 40. mu.L of 0.5mol/L EDTA in 1mL of SM solution) while 10. mu.L of 10% SDS was added per 1mL of SM solution. Starting from the protease addition step, the viral RNA extraction Kit (Tiangen) was used for extraction using the DP315-R TIANAmp Virus RNA Kit. After the DNA was verified by gel electrophoresis, its concentration and purity were determined using Eppendorf BioPhotometer Plus. The product is sent to military medical science institute for sequencing to obtain:

the bacteriophage brachyury BP-13(Podoviridae sp. BP-13) has a nucleotide sequence shown in SEQ ID No. 1;

staphylococcus aureus BP-13A (Staphylococcus aureus cage BP-13A) has a nucleotide sequence shown in SEQ ID No. 2;

the bacteriophage brachyury BP-14(Podoviridae sp. BP-14) has a nucleotide sequence shown in SEQ ID No. 3;

the brachyury phage AHJD-like phage genus BP-39(Podoviridae picovirinae Ahjdrikakikevir BP-39) has the nucleotide sequence shown in SEQ ID No. 4.

Example 4: detection test for deletion of virulence gene or undesirable gene of bacteriophage

44 virulence genes identified as being derived from lysogenic phages within pathogenic bacteria (Table 1) were selected and analyzed bioinformatically by determining the complete genome of the phages BP-13, BP-13A, BP-14 and BP-39 to determine whether they contained the virulence genes described above. The results show that none of the 4 tested phages of the invention contained the following virulence genes.

TABLE 1 major known virulence genes of lysogenic phages in pathogenic bacteria

Example 5: phage MOI and determination of potency

A single colony of staphylococcus aureus J1 is picked and inoculated into a test tube containing 3mL of TSB culture solution, and the shaking culture is carried out for 12h at 160rpm in a shaking table at 37 ℃ to obtain host bacterium suspension. The bacterial suspension was transferred to 10mL of TSB culture medium at a ratio of 1: 100, and cultured with shaking at 37 ℃ and 160rpm until the pre-logarithmic phase. Phage 4 phage pure culture solutions and host bacteria (MOI ═ phage count/bacteria count) were added at a ratio of 10, 1, 0.01, and 0.0001 for multiplicity of infection, respectively, and TSB broth was added to make the total volume of each tube the same. The cells were cultured with shaking at 160rpm in a shaker at 37 ℃ for 6 hours. After the culture, 10000g of the suspension is centrifuged for 10min, and the supernatant is collected, and the titer of the phage is measured according to the following method: using SM as a diluent, the stock solutions of phages BP-13, BP-13A, BP-14 and BP-39 (prepared in example 1) were each diluted in 10-fold gradient to 10⁷And (4) doubling. Respectively take 10⁵、10⁶And 10⁷And uniformly mixing 100 mu L of diluted phage culture solution and 300 mu L of host bacteria multi-drug resistance staphylococcus aureus solution, and standing for 15min to ensure that the diluted phage culture solution is fully combined with receptors on the surfaces of the bacteria. Adding the mixed solution into 4mL of semi-solid agar culture medium cooled to 47 ℃, uniformly mixing, immediately spreading on a solidified solid agar plate, and performing inverted culture at 37 ℃ for 6-8h after the agar is solidified. Three replicates of each dilution were taken and counted as the average of the three replicates of that dilution. Here, the phage titer (pfu/mL) is the average plaque number × dilution × 10. Each point was subjected to duplicate multi-tube culture and averaged to obtain the MOI producing the highest phage titer as the optimal multiplicity of infection. The experiment was repeated 3 times. The results are shown in Table 2.

The result shows that the titer of the phage BP-13 reaches the highest (2.1 multiplied by 10) under the condition of culturing for 6h¹⁰pfu/mL), its MOI is 0.01; the titer of the phage BP-13A reaches the highest (6.8 multiplied by 10)⁸pfu/mL), its MOI is 0.1; the titer of the phage BP-14 reaches the highest within 6h (5 multiplied by 10)¹¹pfu/mL), its MOI is 0.001; the titer of the phage BP-39 reaches the highest (2.0 multiplied by 10)⁹pfu/mL), the MOI was 0.01.

TABLE 24 phage MOI values

Example 6 preparation of phage cocktail compositions

Subpackaging the phage solution obtained by enrichment in example 5 into 50ml centrifuge tubes, wherein each tube contains 40ml of phage solution; adding solid PEG8000 (final concentration is 10%, namely 40ml is added with 4g), and after complete dissolution, carrying out ice bath for at least 3 h; centrifuging the phage at 4 ℃ and 12000rpm for 20 min; discarding the supernatant, and fully dissolving the precipitate by using an equal volume of SM buffer solution; the phage SM eluate was filter-sterilized using a 0.22 μm filter. After titer was checked, the phages were diluted and mixed individually according to the requirements in table 3. The total titer of the finally obtained cocktail mixed liquor is 1.2 multiplied by 10⁷pfu/mL, the effective working titer per unit volume of each phage was equal.

TABLE 3 different phage compositions and ratios

Example 7: determination of pH and temperature stability of phage and phage cocktail compositions

7-1: stability of phages at different pH conditions

The titer is 1.2 multiplied by 10⁷pfu/mL BP-13, BP-13A, BP-14 and BP-39, and the total titer was 1.2X 10⁷pfu/mL phage cocktail mixture BP-13+ BP-13A + BP-14, BP-13+ BP-13A + BP-39, BP-13+ BP-14+ BP-39, BP-13A + BP-14+ BP-39 and BP-13+ BP-13A + BP-14+ BP-39 (from example 6) were incubated at 4 ℃ for 24 hours in SM at pH3, 5, 7, 9, 11, respectively, and then the titer was measured.

As shown in table 4, the titers of the 4 phage strains did not change significantly between pH5 and pH9, indicating that they are stable under neutral, slightly acidic and slightly basic conditions.

Under the condition of pH3, the 4 phage only BP-39 still has the titer of about 3 th, but the titer is reduced by 4 orders of magnitude compared with the neutral condition, which shows that the phage BP-39 has certain acid resistance compared with the rest phage;

under the condition of pH11, the titer of 4 strains of phage only BP-14 still has about 4 th power, but is reduced by 3 orders of magnitude compared with the neutral condition, and the phage BP-14 has certain alkali resistance compared with the rest phage.

Cocktail mixtures comprising 3 or all 4 of 4 single phages such as BP-13, BP-13A, BP-14 and BP-39, BP-13+ BP-13A + BP-14, BP-13+ BP-13A + BP-39, BP-13+ BP-14+ BP-39, BP-13+ BP-13A + BP-14+ BP-39 and BP-13+ BP-13A + BP-14+ BP-39 have no significant change in potency between pH5 and pH9, which indicates that the cocktail mixtures of 4 kinds have good stability under neutral, slightly acidic and slightly alkaline conditions.

The cocktail mixture BP-13+ BP-13A + BP-39, BP-13+ BP-14+ BP-39, BP-13A + BP-14+ BP-39 and BP-13+ BP-13A + BP-14+ BP-39 containing BP-39 still has the titer of about 3 times under the condition that the pH value is 3,

and the cocktail mixtures BP-13+ BP-13A + BP-14, BP-13+ BP-14+ BP-3, BP-13A + BP-14+ BP-39 and BP-13+ BP-13A + BP-14+ BP-39 containing BP-14 still have the titer of about 4 times under the condition that the pH value is 11. It is shown that BP-39 and BP-14 can effectively expand the pH adaptation range of the phage cocktail mixture.

Table 44 stability of Single phages and cocktail thereof at different pH conditions

7-2: stability of phages under different temperature conditions

The titer is 1.2 multiplied by 10⁷pfu/mL BP-13, BP-13A, BP-14 and BP-39, and the total titer was 1.2X 10⁷The titer of the pfu/mL phage cocktail mixtures BP-13+ BP-13A + BP-14, BP-13+ BP-13A + BP-39, BP-13+ BP-14+ BP-39, BP-13A + BP-14+ BP-39 and BP-13+ BP-13A + BP-14+ BP-39 (prepared in example 6) was measured at 4 deg.C, 25 deg.C and 37 deg.C, respectively.

The results show (see tables 5-7), under the condition of 4 ℃, 4 kinds of single phages such as BP-13, BP-13A, BP-14, BP-39 and the like, and phage cocktail mixtures of the 4 kinds of phages, BP-13+ BP-13A + BP-14, BP-13+ BP-13A + BP-39, BP-13+ BP-14+ BP-39, BP-13A + BP-14+ BP-39 and BP-13+ BP-13A + BP-14+ BP-39 have better stability, the titer is not obviously reduced after 3 months of storage, and the titer is only reduced by one order of magnitude after 12 months of storage; under the condition of 25 ℃, 4 single phages such as BP-13, BP-13A, BP-14, BP-39 and the like, and phage cocktail mixtures of the 4 single phages, BP-13+ BP-13A + BP-14, BP-13+ BP-13A + BP-39, BP-13+ BP-14+ BP-39, BP-13A + BP-14+ BP-39 and BP-13+ BP-13A + BP-14+ BP-39 have no obvious reduction of the titer within one week, and after 4 weeks, the titer is only reduced by 1 order of magnitude approximately; at 37 ℃, 4 single phages such as BP-13, BP-13A, BP-14, BP-39 and the like, and phage cocktail mixtures of the 4 single phages, BP-13+ BP-13A + BP-14, BP-13+ BP-13A + BP-39, BP-13+ BP-14+ BP-39, BP-13A + BP-14+ BP-39 and BP-13+ BP-13A + BP-14+ BP-39, have no obvious titer reduction within 24 hours, and after 72 hours, the titer reduction is only about 1 order of magnitude. Therefore, the cocktail mixture composed of the 4 phages has better stability under different temperature conditions.

TABLE 54 stability of phage and cocktail thereof at 4 deg.C

TABLE 64 stability of phage and cocktail thereof at 25 deg.C

Stability of Table 74 phage and cocktail thereof at 37 deg.C

Example 8 human drug resistance Staphylococcus aureus lytic Range assay

The lysis profile of the phage was determined by double-plate titration. Single colonies of 31 methicillin-sensitive staphylococcus aureus (MSSA), 97 methicillin-resistant staphylococcus aureus (MRSA) and 5 marginal anti-benzasoxazosin penicillins staphylococcus aureus (BORSA) obtained by clinical separation are respectively picked, inoculated into a test tube containing 3mL of TSB, and cultured for 8h at 160rpm, and bacterial liquids of all strains are prepared. mu.L of the bacterial suspension was mixed with the semi-solid medium and spread on a common agar plate, 5. mu.L of each phage and its cocktail solution (prepared from example 6) were dropped on different positions of the plate, and the phage culture solutions were not in contact with each other during the sample application, so as not to affect the test results. After natural air drying, culturing for 6-8h at 37 ℃, and observing the result. The experiment was repeated three times.

The results are shown in the table8It shows that BP-13, BP-13A, BP-14 and BP-39 have wide host range, and the cracking rates can respectively reach 67.66%, 78.51%, 63.99% and 64.66%.

The cracking rates of the phage cocktail mixtures BP-13+ BP-13A + BP-14, BP-13+ BP-13A + BP-39, BP-13+ BP-14+ BP-39, BP-13A + BP-14+ BP-39 and BP-13+ BP-13A + BP-14+ BP-39 are 97.74%, 89.47%, 88.72%, 97.74% and 97.78%, respectively. Therefore, the cocktail mixture adopting the 4 phages has a far higher spectrum range of lysis of the human staphylococcus aureus than that of a single phage.

TABLE 8 determination of the lysis Profile of bacteriophages to human Staphylococcus aureus

Note: "+ + + +" is completely clear, "+" is moderately clear, "+" is slightly clear, and non-lysing is "-".

Example 9 lysis Range assay for Staphylococcus aureus of animal origin

The lysis profile of the phage was determined by double-plate titration. Single colonies of 44 animal-derived staphylococcus aureus strains are respectively picked, inoculated into a test tube containing 3mL of TSB, and cultured at 160rpm for 8h to prepare bacterial liquid of each strain. mu.L of each bacterial suspension was mixed with the semi-solid medium and plated on common agar plates, and 5. mu.L of each phage and its cocktail solution (prepared from example 6) was dropped onto different positions on the plates. When the sample is added, the phage culture solutions cannot be contacted with each other so as to avoid influencing the test result. After natural air drying, culturing for 6-8h at 37 ℃, and observing the result. The experiment was repeated three times. As shown in Table 9, BP-13, BP-13A, BP-14 and BP-39 have a wide host range and the respective cleavage rates are 61.36%, 84.1%, 50% and 65.9%. The cracking rates of the phage cocktail mixtures BP-13+ BP-13A + BP-14, BP-13+ BP-13A + BP-39, BP-13+ BP-14+ BP-39, BP-13A + BP-14+ BP-39 and BP-13+ BP-13A + BP-14+ BP-39 are 100%, 100%, 65.9%, 100% and 100%, respectively. Therefore, the cocktail mixture adopting the 4 phages, except the combination of BP-13+ BP-14+ BP-39, has a much higher spectrum range of lysis spectrum for the staphylococcus aureus of animal origin than that of single phage.

TABLE 9 determination of the lysis Profile of Staphylococcus animal origin

Note: can be divided into "+ + + +" clear, "+" medium clear, "+" slight clear, and "minus" without cleavage "

Example 10: lysis test of bacteriophage against non-pathogenic E.coli

10 non-pathogenic escherichia coli colonies are picked and inoculated into test tubes containing 3mL of TSB respectively, and are cultured for 8 hours at 160rpm, and bacterial liquid of each strain is prepared. 300. mu.L of each bacterial suspension was mixed with the semi-solid medium and plated on a common agar plate. mu.L of each phage culture solution (prepared in example 6) was dropped onto different positions of the plate, and the phage culture solutions were not in contact with each other during the sample application, so as not to affect the test results. After natural air drying, culturing for 6-8h at 37 ℃, and observing the result. The experiment was repeated three times. As shown in Table 10, in this study, neither 4 phages nor the cocktail thereof recognized 10 tested E.coli strains. The test phage has strong specificity and has no damage to microbial community.

Lysis test of Table 104 phages and cocktail thereof against non-pathogenic E.coli

Note: "+ + + +" is completely clear, "+" is moderately clear, "+" is slightly clear, and non-lysing is "-".

Example 11: lysis assay of bacteriophage against non-host pathogenic bacteria

30 single colonies of non-host pathogenic bacteria are picked, and comprise 5 strains of streptococcus dysgalactiae, 5 strains of streptococcus agalactiae, 5 strains of vibrio parahaemolyticus, 5 strains of pseudomonas aeruginosa, 5 strains of klebsiella pneumoniae and 5 strains of acinetobacter baumannii. Respectively inoculating the strains into test tubes containing 3mL of TSB, and culturing at 160rpm for 8h to obtain bacterial liquid of each strain. 300. mu.L of each bacterial suspension was mixed with the semi-solid medium and plated on a common agar plate. mu.L of each phage culture solution (prepared in example 6) was dropped onto different positions of the plate, and the phage culture solutions were not in contact with each other during the sample application, so as not to affect the test results. After natural air drying, culturing for 6-8h at 37 ℃, and observing the result. The experiment was repeated three times. The results show that neither 4 phages nor their cocktail identified any of the 30 tested non-host pathogenic bacteria (table 11). The test phage has strong specificity and has no damage to microbial community.

Lysis test of Table 114 phages and cocktail thereof against non-host pathogenic bacteria

(Note: "+++" is fully clear, "+++" is moderately clear, "+" is slightly clear, and non-lysing is "-")

Example 12: bacteriostatic effect test of bacteriophage on staphylococcus aureus

Taking 10 conical flasks filled with 50ml of sterile TSB culture medium, wherein the serial numbers are 1-10; 10 bottles of culture medium are respectively inoculated with bacteria (from golden yellow grape which is the cause of human burn infection in a hospital in Zhejiang province)Coccus ZJ-42 or Staphylococcus aureus SDN-12)100 μ l of cow mastitis pathogenesis in certain dairy farm in Shandong province; no.1 was added to a final concentration of 1.2X 10⁷BP-13, No.2 of pfu/ml was added to a final concentration of 1.2X 10⁷pfu/ml BP13-A, No.3 added to a final concentration of 1.2X 10⁷BP-14, No.4 of pfu/ml was added to a final concentration of 1.2X 10⁷BP-39, No. 5 of pfu/ml was added to a final concentration of 1.2X 10⁷The mixed solution of BP-13+ BP-13A + BP-14 with pfu/ml, No. 6, added to the solution with the final concentration of 1.2X 10⁷pfu/ml BP-13+ BP-13A + BP-39 mixture, No. 7 added to final concentration of 1.2X 10⁷pfu/ml BP-13+ BP-14+ BP-39 mixed solution, No. 8 added to final concentration of 1.2X 10⁷pfu/ml BP-13A + BP-14+ BP-39 mixture, No. 9 added to final concentration of 1.2X 10⁷pfu/ml BP-13+ BP-13A + BP-14+ BP-39 mixture, No. 10 added with the same volume of SM buffer as above phage. The mixture was placed in an incubator at 37 ℃ for action. Taking out 2ml at 0h, 3h, 6h, 24h, 48h and 96h respectively, and detecting OD₆₀₀Numerical values.

The result shows that 4 phage individually have obvious inhibition effect on ZJ-42 within 24 hours, the inhibition effect is obviously reduced after 24 hours, and the cocktail mixture of 4 phage has obvious inhibition effect on ZJ-42 within 48 hours, and the effect is obviously better than that of single phage; the 4 phages have obvious inhibition effect on cow mastitis pathogenic bacteria SDN-12 within 48 hours, the inhibition effect is obviously reduced after 48 hours, and the cocktail mixture of the 4 phages still has obvious inhibition effect on SDN-12 within 96 hours. Therefore, the bacteriostatic effect of the cocktail mixture is obviously superior to that of a single-strain bacteriophage. See tables 12-13 for details

Bacteriostatic effect of surface 124 strain phage on burn infection staphylococcus aureus ZJ-42

Bacteriostatic effect of surface 134 strain phage on bovine mastitis pathogenic staphylococcus aureus SDN-12

Sequence listing

<110> Philippinecaceae (Nanjing) Biotech Ltd

<120> novel staphylococcus aureus bacteriophage, and composition and application thereof

<130> LAC210207P

<160> 4

<170> SIPOSequenceListing 1.0

<210> 1

<211> 18178

<212> DNA

<213> Podoviridae sp. BP-13

<400> 1

aatagggaaa aagtttttgt aaaattacac ccacccaccg tttaaaataa acgattatac 60

aaatcaaaac ttataaattc acttatcatt tctttactaa acttataaat actgtttgac 120

aacttaacaa cttatctaac ctataacata ttcatcaaat acaaaattta tgtatctatt 180

gacttttatt caaaattatg attttaacac aaaataaatt taatttactt atttaaatat 240

tctatgatat aattagatat aaaataattg gaggtgtgta ttaatgtctg agtttgaaga 300

aattattaaa ccagaagata aagaatcaac agaatcaaca gaagaatcaa cagaatcaac 360

agaatcaaca gaatcaacag aatcaacaga agaaactgaa gaatcatctg aaagtgaatc 420

agtagaaaca attgaagaag aaaatgaaaa caaattagaa cctactatta ctgatgaaga 480

tagtgcaaaa ttagaccctg ttgttttaga acaacgtatc gcttcattag aacaacgatt 540

tactaatttt gaaacatcac aaatgcaaca accacaacca caaccacaac cacaaccaga 600

tgttactgaa gcagatgaca acgacaaaga ctattcagat gaagaattag tggataagtt 660

agatttagat taggaggaat ttaaacatgt atgaaggtaa caatatgcgt tctatgatgg 720

gtacatcata tgaagattca agattaaata aacgaacaga attaaatgaa aatatgtcaa 780

ttgatacaaa caaaagtgaa gatagttatg gtgtacaaat tcattcactt tcaaaacaga 840

catttactgg cgatgtagag gaggaataat aaatcatggc agaaaagagt acaaaaaacg 900

aaacagcact attagttgca cagtcagcta aatctgcatt acaagacttt aatcatactt 960

attcaaaatc atggacgttt ggtgataagt gggataattc taatacaatg tttgaaacat 1020

ttgttaataa atttttattc cctaagatta atgaaacgtt attaatcgat attgcattag 1080

gtaaccgttt taattggtta gctaaagagc aggactttat cggtcaatac agtgaagaat 1140

atgtaattat ggatacagta cctattaaca tggacttatc taaaaatgaa gaactaatgt 1200

tgaaacgtaa ctatccacgt atggctacta agttatatgg tagtggtatt gtgaagaaac 1260

aaaaattcac attaaacaac aatgatacac gtttcaattt ccaaacatta gcagacgcaa 1320

ctaattatgc tttaggtgtc tataaaaaga aaatttctga tattaacgta ttagaagaaa 1380

aagaaatgcg tgcaatgtta gttgattact cattgaatca attatctgaa tcaaatgtac 1440

gtaaagcaac atcaaaagag gatttagcaa gtaaagtttt tgaagctatt cttaacttac 1500

aaaacaacag tgctaaatat aatgaagttc atcgtgcttc aggtggtgct atcggacaat 1560

atacaacagt ttcaaaatta aaagatattg ttattttaac gactgatagc ttaaaatctt 1620

atcttttaga tacaaagatt gcgaacactt tccaagtagc aggtattgac tttacagacc 1680

atgttattag ttttgatgac ttaggtggtg tttttaaagt cactaaagat attgtcgtat 1740

caagtgatgt atcagttaat ttcttacgtg cttacggtga ttaccaaact cataaaggtg 1800

atacaattcc agttggttca gtattcactt atgatgtatc aaatttatct gaatttaatt 1860

ctaacgttga agaaattaaa ccaaaatcag atttatacgc atttattttg gatattaatt 1920

caattaaata caaacgctat acaaagggta tgttaaaaca accattctat aatggtgaat 1980

ttgatgaagt cacacactgg attcattatt attcatttaa agccattagc ccattcttta 2040

ataaaatttt aattaccgac caagatgtaa caccaagaac agaataatag aggtgctata 2100

aatgactaaa cataataaag gcgtacaggt tgaattatct aaagaaatca ataaacgtgt 2160

cgtagaacat cgcaacagat ttaaacgtct tatgtttaat cgttatttgg aatttttacc 2220

actattaatt aactatacca atcgtgatac ggttggtata gattttattc aattagaatc 2280

tgcattaagg caaaacatta atgtagttgt tggtaaagca agaaatgaac aaatcatgat 2340

tttgggctat gttaacaaca cttattttaa tcaagcccca aatttttcat caaatttcaa 2400

ttttcaattt caaaaacgat taacaaaaga tgatatttat ttcattgtcc cagactattt 2460

aataccagat gaatgcttac agattcataa aatatatgat aactgtatga gtggtaactt 2520

tgttgtaatg caaaataaac caattcaata taatagtgat atagaaatta tagaacatta 2580

tactgatgaa ttatctgagg ttgttttatc tagattctcg ttaattatgc aagcaaaatt 2640

tagcaaaata tttaaatcag acattaatga cgagtcagtt aatcaacttg tatcggaaat 2700

atacaacggt gcaccatttg ttaaaatgtc acctatgttt aatgcagatg atgatatcat 2760

agatttaacc agtaatagtg tgattccagc actaactgag atgaaacgcg aataccaaaa 2820

caaaattagt gaattaagta actatttagg tattaattca ctagcagtgg ataaggaaag 2880

cggtgtttcg gacgaagagg caaaaagcaa ccgaggtttt actacatcaa atagtaatat 2940

ttatttaaaa ggtcgtgaac cgattacatt cttatcaaaa cgttatggtt tagatattaa 3000

accgtattac gacgatgaag ttacttcaga aatcacaatg atagatacat tgtctaatga 3060

tgaaagtagt gaatacaatg gctagatata caatgacttt atttgatttt attaaatcag 3120

aattaattaa aaaaggtttt aatgaatttg taaataatga taaattaacg ttttatgatg 3180

atgaatttca attcatgcaa aaaatgttga agtttgataa agacgtttta tccatcgtta 3240

atgaaaaagt gtttaaaggt tttaaactta aagatgactt atctgactta ctttttaaaa 3300

aatcatttac aatacacttt ttagatagag aaatcaacag acaaacagtt gaagcttttg 3360

gcatgcaagt gattactgta tgtatcacac atgaggatta tttaaacgtt gtatattcat 3420

caagcgaagt tgaaaaatat ctacaatcac aagggtttac agaacataat gaagatacaa 3480

caaacaacac tgatgaaacc tcaaatcaaa acgctacatc tttagacaat tcaactggta 3540

tgacagcaaa cagaaatgct tatgtgtcat taccacaaag cgaggttaac atagatgtag 3600

ataacacaac gttacgattt gcagataata atacaattga taacggtaaa actgtgaata 3660

aatcaagtaa cgaaagtaat caaaacgcaa aacgtaatca aaatcaaaaa ggtaatgcga 3720

aaggcacaca attttcaaaa cagtatttaa ttgataatat tgataaagta tacgatttaa 3780

gaaagaaaat tttaaatgaa tttgataaaa aatgtttttt acaaatttgg taaaggtgga 3840

aaattatggt atataatgaa aacgatttta aatattttga cgacattcgt ccatttttag 3900

acgaaatata taaaacgaga gaacgttaca caccgtttta cgatgataga gcagattata 3960

ataccaattc aaaatcatat tatgattata tttcaagatt atcaaagctc attgaagtat 4020

tagcacatcg tatttgggac tatgacggtg agttaaaaaa acgttttaga aactgggacg 4080

atttaatgaa agcattccca gaacaggcta aagacttatt tagaggttgg ctcaatgacg 4140

gtacaataga taacatcatt catgatgaat ttactaaata tagtgctggt cttacatccg 4200

catttgcatt atttaaagtt gcagaaatga aacaaatgaa tgactttaaa gcagaagtga 4260

aagacttaat caaagatatt gaccgtttcg ttaatggttt tgaattaaat gaacttgaac 4320

caaagtttgt gatgggtttt ggtggtattc gtaatgctgt taaccaatct attaatattg 4380

ataaagaaac aaaccatatg tactctacac aatcagattc acaaaaacca gagggttttt 4440

ggattaataa attaacgcct agtggtgatt taatatctag tatgcgtatt gtacaaggtg 4500

gtcacggtac tacaataggt ttagaacgtc aatccaatgg tgaaatgaaa atatggttac 4560

atcatgacgg tgtagcaaaa ctgttacaag ttgcatataa agataattat attttagatt 4620

tagaagaagc aaaaggctta acagattata caccacattc acttttaaac aaacacacgt 4680

ttacaccgtt aattgatgaa gcaaatgaca aaatcgtttt aagattcggc gacgggacaa 4740

tacaggtacg ttcaagagct gacgtaaaaa atcacattga taatgtagaa aaagaaatga 4800

cgattgacaa ttcagaaaac aatgataatc gatggatgca agggattgcc gttgacggtg 4860

atgatttata ctggttaagt ggtaacagtt cagttaattc acacgttcaa attggtaaat 4920

attcattaac aacaggtcaa aagatttatg attatccgtt taaattatca tatcaagacg 4980

gaattaattt cccacgtgat aactttaaag agcctgaggg tatttgtatt tatactaatc 5040

caaaaacaaa acgtaaatcg ttattacttg ctatgacaaa tggcggtggt ggaaaacgat 5100

tcaataattt atatggtttc ttccaacttg gagaatatga acactttgaa gcattacgtg 5160

cgagaggttc acaaaactat aaattaacaa aagacgatgg acgtgcgtta tcaattccag 5220

accatattga cgacttaaat gacttaacac aagcagggtt ctattatatt gacggtggta 5280

cagctagtaa acttaaaaat atgccaatga atggtagtaa aaaaattata gacgctggtt 5340

gtttcatcaa tgtataccct acaacacaaa cattaggtac agtacaagaa ttaacgcgtt 5400

tttctactgg tcgaaaaatg gttaaaatca tgcgtggtat gacgctcgat gtatttacat 5460

taaaatggga ttatggttta tggacaacaa tcaaaacaga cgcaccatat caagagtatt 5520

tagaagcaag tcaatataat aactggatag cttacgttac aatacctggt gaatattata 5580

ttacaggtaa ccaaatggaa ttatttagag acgctccaga agaaattaaa aaagtgggtg 5640

catggttacg tgtttcaagt ggtaacgccg ttggtgaagt cagacaaaca ttagaggcta 5700

atgttaaaga gcacaaagag tactttagta acgttaatgc ggaaacgaaa catcgtgagt 5760

atgattgggt taagaaagga taatgttgca atgaaatcac aacaacaagc gaaagattgg 5820

atatataaac atgagggtgt tggcgttgac tttgatggag catatggttt tcaatgtatg 5880

gacttagcag ttgcttatgt ttattacatt actgacggta aagttcgcat gtggggtaac 5940

gccaaagacg ccattaacaa cgactttaaa ggtttagcag cggtgtatga aaatacacct 6000

agctttaaac ctcaattagg tgacgttgct gtatacatta attctcaata tgggcatatt 6060

caatgtgtaa caagtggaaa tcttgattat tatacatgct tagaacaaaa ctggttaaat 6120

ggtggatatg atggttggga aaaagcaaca ataagaacac attattatga cggtgttacg 6180

cattttattc gtccaaaatt ttcaaatagt gatagtaaag tattagaaaa aaatattcaa 6240

caaactaaca actggaaaca aaaccaatac ggcacatatt acagaaatga aaatgctaca 6300

tttacatgtg gttttttacc aatatttgct cgtgtcggta gtccgaaatt atctgtgctt 6360

aatggctatt ggttccaacc aaacggctat acaccatatg acgaagtttg tttatcagac 6420

aggtatgtat ggattggtta caattgggaa ggtacacgtt attatttacc agtgagacaa 6480

tggaacggta aaacaggtaa tagttacagt gttggtattc cgtggggggt gttctcataa 6540

tgggtatttt aggttttttc tttgagttta gttggaaacg atacaaataa gaggtgtgaa 6600

caatggctga tagaatcgta agaagtttaa gacaagttga aacaatagac aggttagcag 6660

attttttaac agaagaaaat gacttaatca gtacatcaga cggacatatt tatgtccgta 6720

ctgatactgg ttattataaa ttaacatttt ataatgattt aaaaacattg attaataaat 6780

acagtggtca aatagaaaat catgatattg caattaatga taataaagag aaaatatcaa 6840

catttctaga gaaaataaaa aaattacaac caatgattga tagtaataaa aaagagattg 6900

attcattaaa agaaaaagat gtcatattaa atgaaagttt agaacaacat caaacacaat 6960

taaatgaatt tgaaaaatca atgttacagt atgatgataa atatgaaaca cttacacaat 7020

cgttaaacgc tactaaagat agtgtaggac gaaacacaaa tgaaattaat ttaattaaag 7080

ctaatactgg tgcagaaaac attgacgcgt taaaaagaga attagctgaa gttaaaaaaa 7140

gtatcaatct tgataaaata aaagatattg aacaacagat tgaattatta aaatctaaac 7200

aaaacaatga caacacaatt caagaaatac aagaggatat taataagtta aaacaaaatt 7260

caagtgctgg gaaacttgaa agtttagaac aaaccattaa tgacatcaaa gcaaatgcca 7320

accttgataa gataaaagag ttagaaacaa aattaaacag tattaaccaa aaagattata 7380

cacaggatat taattcaatt aaatctgaca tcgctgcttt aaaaacaaat aatgataaaa 7440

tatcaaaaat tgaaaaagat attcaagaat taaaagatag accagttgtt gacggaaacg 7500

gacatattga tttatcaaaa tatgataatg atattaatga tttaaaacaa aaaacatcaa 7560

caaatgaatc aagtattaac actttatcaa caagagtgga caacttaaat atagatacta 7620

aaattgcaca atctaaatca gaaattgaac aaaattttga tcaaaaaatc aacagtgcaa 7680

aattacaatt taatgataca ggttggcaag atatatcgct agaaagtggt atagttgcaa 7740

gtgatagcaa cggtggttat cccgcaccgc aatatcgtat tgtaacaatt aatggtgtta 7800

aaaccataca attaaaaggg gtattaaaag ggattaagaa aaacggtgat attaaattag 7860

gtacgattaa cgctaactta aaatcaacac atcactacac acaatgtgcg attgattcga 7920

aaatgattaa tacaagatta tatttaaact ttagtaatga attacatttt gttacatcaa 7980

attatagcga tagtgactta acaaatggag ataaacgttt tgcaatagat acacaaatca 8040

ttgaataaaa atgttataat agtcgtataa attatttata cgactatttt ttatggaggt 8100

aaaaatgaga aaattaacaa attttaaatt tttctataac acaccgttta cagactatca 8160

aaatacaatt cattttaata gtaataaaga gcgtgatgat tattttttaa acggtcgtca 8220

ttttaaatca ttagactatt ccaaacaacc gtataatttt atacgtgata gaatggaaat 8280

caatgttgat atgcagtggc atgacgcaca agggattaac tacatgacgt ttttatcaga 8340

ttttgaggac agacgctatt acgcttttgt gaatcaaatc gaatatgtga atgatgttgt 8400

ggtaaaaata tattttgtga ttgatactat tatgacgtat acacaaggta atgtattaga 8460

acaactttca aacgttaata ttgaacgtca acacttatca aagcgtacgt ataactatat 8520

gttgccgatg ttacgtaaca atgatgatgt gttaaaagta tcaaataaaa actatgtgta 8580

taaccaaatg caacagtatt tggaaaattt agtgttattc cagtcaagcg ctgatttatc 8640

aaagaaattt ggtacgaaaa aagagccaaa cttagatacg tctaaaggta cgatatatga 8700

caatatcaca tcgccagtca acttatacgt tatggaatat ggtgacttta ttaactttat 8760

ggataaaatg agtgcatatc catggattac acaaaacttt caaaaggttc aaatgttacc 8820

taaagatttt attaatacaa aagatttaga ggacgttaag acaagtgaaa aaattactgg 8880

attaaagaca ttaaaacagg gtggaaaatc aaaagaatgg agtttaaacg atttatcatt 8940

aagtttcaca aagcttcaag agatgatgtt gtctaaaaaa gacgagttta aacatatgat 9000

acgtaatgag tacatgacga ttgaatttta tgactggaac ggtaacacaa tgttacttga 9060

cgctggtaaa atttcacaaa aaacaggtgt taagttacgt acaaaatcca tcattggtta 9120

tcataatgaa gtgcgagtat atccagttga ttataacagt gctgaaaacg atagaccgat 9180

acttgctaaa aataaagata tattaattga tacaggttca ttcttaaata ccaatataac 9240

atttaatagt tttgcgcaag tgcctatatt aattaataac ggaattttag gacaatcaca 9300

acaagccaat agacagcgta atgcagaaag tcaattaatc acaagtcgta tagataatgt 9360

attaaatggt agtgacccaa aatcacgttt ttatgacgct gtaagtgtag caagtaattt 9420

aagtccaacc gctttatttg gtaagtttaa tgaagaatat aatttctaca aacaacaaca 9480

ggcagaatat aaagatttag ccttacaacc accatctgtg acagaatcag aaatgggaaa 9540

cgcattccaa attgcaaata gcattaacgg tttaacgatg aaaattagtg taccgtcacc 9600

taaagaaatt acatttttac aaaaatatta tatgttgttt ggttttgaag taaatgacta 9660

taatacattc attgaaccta ttaacagcat gactgtatgc aactatttaa aatgtacagg 9720

tacgtatacc atacgtgaca ttgaccctat gttaatggaa caattaaaag caattttaga 9780

atctggtgtg agattttggc ataatgacgg ttcaggtaat ccaatgttac agaacccgtt 9840

aaataataaa tttagagaag gtgtataaaa tgaatgaggt aaaattaaga tttacggaca 9900

cagaagcatt tcatatgttc atatatgcag gtgatttaaa gttactatat tttttatttg 9960

ttttgatgat tatagatgtt gttactggtt ttgctaaagc aattaaaaat aataatctat 10020

ggtctaaaaa atcaatgaaa ggttttgcta aaaaattatt gatattctgt attatcattt 10080

tagctaacat cattgaccag attttacaat taaaaggtgg cttactcatg attacgattt 10140

tctattatat cgctaatgag ggcttatcta tcgtagaaaa ttgtgcagaa atggacgtat 10200

tagtaccaga acaaattaaa gataaattaa gagtaattaa aaacgattct gaaaagggtg 10260

ataataatga acgaccaaga gaagatagat aaatttacgc attcgtatat taatgatgat 10320

ttcggtttaa cgatagacca gttagtccct aaagtaaaag ggtatggacg ctttaatgta 10380

tggctaggtg gtaatgaaag taaaatcaga caagtattaa aagcagtaaa agagataggt 10440

gtgtcaccta ctctttttgc tgtatatgaa aaaaatgaag ggtatagcgc tggtttaggt 10500

tggttgaacc atacatctgc acgaggtgac tatttaacag acgctaaatt cattgcaaga 10560

aaattagtat cacaatcaaa acaagcagga caaccgtctt ggtatgacgc aggtaacatc 10620

gttcactttg tacctcaaga cgtacaaaga aaaggtaatg cagattttgc taaaaatatg 10680

aaagcaggta caatcggacg tgcgtatatt ccattaacag cagcggctac ttgggcggca 10740

tattatcccc taggtttgaa agcgtcatat aataaagtac aaaactatgg taatcctttt 10800

ttagacggtg caaatactat tttagcatgg ggtggtaaat tagacggtaa aggtggttca 10860

cctagtgatt cgtctgacag tggtagtagt ggtgacagtg gtagttcact gctcgcttta 10920

gcaaaacaag ccatgcaaga attattaaaa aaagtacaag acgcattaca atgggatgta 10980

cacagtattg gtagtgataa attttttagt aatgattatt ttacattaca aaaaacattt 11040

aacaacacat atcatattaa aatgacgatt gggctacttg attcattaaa aaaactgatt 11100

gatagtgtgc aagtagatag tggggatagt agttcaaacc ctactgatga tgacggagac 11160

cataaaccaa ttagtggtaa gtcagtcaaa ccaaatggta aaagtggtcg cgtcattggt 11220

ggtaactgga cgtatgcaca gttaccagaa aaatataaaa aagcaattgg tgtaccttta 11280

ttcaaaaaag aatacttgta caaaccaggt aacatatttc ctcaaacggg taatgcagga 11340

caatgtacag aattaacatg ggcatatatg tcacaattac atggtaaaag acaaccaaca 11400

gacgacggtc aaataacaaa cggtcaacgt gtgtggtacg tatataaaaa gttaggtgca 11460

aaaacaacac ataatccaac agtagggtat ggtttttcaa gtaaaccacc atacttacaa 11520

gcaacagcat atggcattgg tcacacaggt gtcgttgtag cagtatttga cgatggttca 11580

ttcttagtag ctaactataa tgtaccgccg tacgttgcac cgtcacgcgt agtattatat 11640

acacttatta atggtgtacc agaaaatgca ggtgataata ttgtattctt tagtggtata 11700

gcttaattaa ctatggtata atgaaaacat gctagtaatg ctagtaaata aaatacaaaa 11760

cataatcaat tttcgtacac atttttcatg ttatctcaaa agaaaaaggc gactgttatt 11820

taacagttgc ctttttttaa ttcatcgtgt tcacgtttta atatatgcaa attagattta 11880

ttatgcactg aacgtacaac tggaaataag tcattaagtg agaatgaacc gatgtcactt 11940

tcaatataaa gaatatcatc aaattgacta tggtcaaaat tttctctagc gtcttttaag 12000

ataaattcac gtttcatatt aagttcatca gtaaaatatt catcatatac attaccgcat 12060

acaatttctg ttttagacgg ataaatcgat atcgtaccct gttcgttata gatactttta 12120

ttgttttcta ttatcgcacc gtcaaagaat tgttcacgta caaaggtttc aaaatcgacg 12180

cttgtatcaa aggcgctttt cggtatacca gcagaagcaa ttttaatctt tccattcact 12240

tcatatgcat attttttatg attcagtaca aacatcttat ctatctgttc gttttcaata 12300

tcccatttac ctaaggctat cgggtcgaat aaactggggt tcaataaggg tttaacaacg 12360

gatttcatat acaaactatc agtatcgcaa taaataaaat tgtcgtcaat ttcattttca 12420

gttaagtatt ggaaaggtac caataagtta tataatgaac gtgatgtgac aaatgtagag 12480

aataatatat tacgttcagt gtttttgtaa ccgttaatga tattatatag ttcgttgtta 12540

tcatctaaac ggaataagtt aaaatgtgaa cgtaatgcag gtatgccata taatccgtta 12600

agtacaactt tagacaacat aacctcctca tttgagtaag ggtgttcgtt gatgtcatca 12660

gtaatatgat agtcgtaagg tgatgtcatg ttgattttgt tttttaactt accttgtgtt 12720

ttaataaaat agttttgaaa tataatatca cgtgcatgaa agtattcaca ttcatatatc 12780

acaaacgaat taacacgtat atgcgtgcaa tcaatacccg taatgtcttg aatcattctt 12840

aatgtatttg tattaatatt aacgtaatca ttatcattat tatagtattt tacaatcatt 12900

tgacgtaata cacgtgattt gattttaatt aataaatcat tgttaaatac atctttatca 12960

atcttatata atgaaaaata attgtcatca tctaaaaaag tagggattaa tgtaggttct 13020

gaataatgtt cataaaagta taaccatgtc ggaattttct catgatacat cacataagga 13080

taactggaat tgatatcaat agaaaaacaa ggctcatcaa taagtttgtt tatgtattta 13140

gtgttataca tatttaaacc accacgataa aatgatttga tatagtcata aaaattcata 13200

tcatggaaat ggtaatgtgt atatgatatt ttaatatctt gatattgatt gagtaactga 13260

aaacgcgtca tttgattatt taaatacgat tccataatat tcaatgaaaa tgttaatttg 13320

ttatagtcaa aatttggaaa tatatcacta taatgaatat ggcacatacc taatataatc 13380

acgtcattat gaatgtatgt aagttgttca ggtgtgagtt tatcaaaaca ctttacggca 13440

tagtcatagg cttcactatc tgacatgtcg ttatctttat caaatatcgt gtaattaaaa 13500

tctgttttaa gttggtcgtc tgttaaataa ccaccgtcaa gcaacttttt acctaatgtt 13560

gcaattgatg tatttgtttt cataaagtta tcaataatat taaatttaaa tccatttaaa 13620

aacattgtta agtctaaatt aatagacgat ttcacacgtt tttctaaaat cacattttga 13680

tttttagcta aaatagtagc ctcttgcatt tttagtgtgt gttcgttttc ttctgcagat 13740

tttaaatata tattttcacg tgtgatatta tcaaaataac gcatggtatc tttaagtaaa 13800

aaatggttgt catacttatt acagttatgt gcaatcatga taatatctgt ttttgactta 13860

gtgattgtat cacgtcgttt cacatacgta taaaatgcgt cataaaacga ttcaaaacta 13920

ggaaatactt ctacatcaat ctcataacca ttaaaccaac caattgctac tgaatacgtt 13980

acgtttttat atttggttgg tttttttctt ccgttaactt tattgtacgc taatgtttct 14040

atatcccagt ataaaatcat tcgacgttca tgtttatgat attgcatgca ttctagtaat 14100

cccataatct tacacacctt ttataagccg tattgtttca ttaaatactt ctttgtattt 14160

tcaatatagt tatcttcata tattttttct tttctttcaa attcactcat atttttcttc 14220

atttcatttt ttatatgaaa ttttataatt ttattcatat ctaaatataa atatctatca 14280

ttatcaacaa cgtaattttt tgagtaagcg ttatcaaaat gtaaattgct tggattgtaa 14340

taataacgct ccatgttttc tttataaaac atatcttctc ttaaataaat aacattgtca 14400

tctatatctt tgattttagt acaaaattca tattgttttg tataaggtat aacaataata 14460

ttagcattaa atgtatcaac attatacata atttttatat atttatcgtc agttttaata 14520

tagaaaaaat caccgttttg attgatatga tttcttaaat tatcatctgc caaattatat 14580

tcgttaaatt caaactcgcc agtagtcata gcgtcatcgt ttgaattgaa tgcccgtgtg 14640

ttacgctttt catttacgta atcgtttctt cgcatttcta aaaaaatgtt tttgtaaagt 14700

cgtgatgtgt tcattttatg tttttgtaat aagttatata tatttaaatt ggataatata 14760

ggacttgaaa agttgactgc attacctagt aaaaacattt tagggaagcc gatataatca 14820

acattaccat ggttacggtc gattgattca taaattgttt ttaacttatc ccactcgtca 14880

attaaatagt catcttcaag tgctaaaaat tcatcatata taatgatagg gtagtgtttt 14940

aaaaagttag aatgatattt taaatcagtt gcactattca aatctgtaat cacaccgatt 15000

tccttatctt gatagatgat agctaaatag tccctagcgc ttctgaatgt gacacgctta 15060

gatttgaata gtgggttttt gtctatgatt tcctcaataa aatcacgata agcgtcacgt 15120

aatgtataat gacgtgataa taaagtaaat ttaatatcaa gttttatagc taaataaata 15180

aagaatgaaa catagttgaa cgattttccg tcagaacggt ttgaaataga tatgtaatag 15240

tctatatcat cattcatgag ttcatcaact aattctattt gattatagtt atctggtatt 15300

ttttttctga catgattgac agtattttga taatctctta ccatgtctaa acgattttgt 15360

ttcaccatgt ttttgctcct tataatagtt tatgatgtcg tttacagtat taaaattagt 15420

cttcaaatgt tgcataatat aaaaagttat acctcacatc ttcatcatca atagtagtca 15480

ctggtctgtc tgatttacca atttctttgt ataaagtgtc aatttccttt atatatttat 15540

acatagaaga attattattt tttgcttgta attcatataa agcatattta tgctttttag 15600

cgtttttatt attagattca tctttacggt tatatatttc aagtatatag tttaattgtt 15660

catgtctttt acctcttacc aatgatacag catttgcata tgacacgttt ctttcttttg 15720

gaaaataggg caaatgtgcg aaatgtttcc atgcgtctat gtacgcctct tgtaaatctt 15780

tatcatcaaa tttaaaatta acagtactaa aatcatttaa aaacaattct ttttcctgct 15840

cttttcttgc ttctctttct tttttccatt tatccatttc ggacgtatgt ctaaccattg 15900

ctaacgacct ccatataaac catatataac cactaaaaag ataatgtaga atataatcaa 15960

tgtagtaaat aaaacaccaa atgacacacg tatatgcatt gtcataagta ttacaagtgt 16020

aattaaaaat gctaaaagga aaacaataat aatatctaat aggttattca tggtctttca 16080

atgctccata atcatatatc attttacctt gataaaacac tactaaatga ctttgaaaag 16140

ggtcgtcaaa ataatctaat aattcatcaa tagtaatatc tgtaaaaatt tcccttttaa 16200

ataatgggtt taaatcttct cgataaaaaa catcaagtaa atcaaatcta tatttataaa 16260

tattgatatt aatatcaata gtaaataaat cttggttcaa attataatca tgattatatc 16320

cctcaaaaaa atctatttta atattacctg aatttattat tacaacacaa ttattattat 16380

tagaaacaaa agtatatttt ttatcattaa atttatcttt attttttaat atatagttga 16440

ttaaatcaac tgaattaaat gtttttttta ttttcatttt tatatctcct taatgtattt 16500

tacacaaaga ttatatgcac cttttttgta aaagtttgag tcaaaataac tatatattac 16560

cttaacttta tttatttttt tcgaattgtt caatttcatg ttcatatatt tcattaattg 16620

atacattgta taataatacg gcagtgtata ttttttccat tgtttagcac ctcataaaaa 16680

taggggataa atatccccta tgaaattgta ttaaaatgat acttgaccaa agttgattga 16740

gtaacctttt tgaccttttt tattttcata ctcataaatt gtgaattgaa cttcaccagc 16800

attgataatg ttaacaacgt cctcgtcttg acgcatttct ttaattaatt cagttaagtg 16860

attcggtaag tttacgttat agtcgtcagt gacgataaca ccttgttcac cgaattttga 16920

ttctttgttt gtgaataatg ctctaacgat atactctttt ttcataccgt atttttctac 16980

taattctgat agtttgataa attctctttc tttttcctca aattcgaatc tcgctaatgt 17040

gttttggtgt cttgataaaa tatcttttac gtttgtcatt tttatttctc ctcttattta 17100

aattatttgc tttctgcaat tgcaatttgt agtaaatcat tgtaataaac ttgcatagtt 17160

ttagtatgtc gtgtagtgga taaaagtttg tgtgtattag gtaataagtc tttcgcttgt 17220

gattttgata aatgatactc gtgaagtggg ataaattctt caacatattc atttttatca 17280

tctaaataat gaaaaatata accttttatt cgtaatgtaa caatatcatc aggtttcatt 17340

attatatcac tcctttctaa aaaacgtaaa cgttatacgt ttcataaaat cctttgtgca 17400

tattccattg ttctattggg tcatcaccag caatgtaaga taaaatagat tctggtttag 17460

tttcgttgtt tagttcatca tttaagaatt taacaacaga actattatag tttaataata 17520

gttgttggca agctgatact aaattaatag cattgtcgaa agtataagct ggattccatt 17580

gaatcaactt attgaatagt tgcaacattt cagtataagc ttgacctttt tcttctggtg 17640

cattatcaat attaaccatt attaacactc cttaattcat tccttatttc atcaacgatt 17700

tttttaggtg aattatggtc taattgttca aaatcgtcct tttcaagtac aaataatgtt 17760

aaatcataag ttgatgtatt acccataaca ataactatat taccattttt aaaatgtaag 17820

tttgtaaagg ttgtacattt tccattttgt tacctccttg atttgattac atacatagta 17880

tagcaaacgt ttaaaagttt tgtcaatggt ttttcttaaa aagtttaaat aatttaaaaa 17940

taatatttaa tagaagaaat tagattttaa atacaaatca taattttgaa taaaagtcaa 18000

tagatacata aattttgtat ttgatgaata tgttataggt tagataagtt gttaagttgt 18060

caaacagtat ttataagttt agtaaagaaa tgataagtga atttataagt tttgatttgt 18120

ataatcgttt attttaaacg gtgggtgggt gtaattttac aaaaactttt tccctatt 18178

<210> 2

<211> 136563

<212> DNA

<213> Staphylococcus aureus phage BP-13A

<400> 2

atagacaaag ctattgtgtt tgataacata ttaacgggta tacaaacaat aggaataaat 60

acaacaacac ctcttaaaaa tattgagcta agttattctt actatggtga taattggaca 120

aacctaaaaa caataagtaa tttaagtcaa ggtgaaacaa taacacctaa taacctagta 180

gatttatatg gcttagaaac aatagattat tcaagtatta cacctttctc tagggttata 240

cttaaaacta tatggaatgc taacctgaat aatttaacaa ataaaaaagg tagtatttct 300

aacatgagca acaactattt caatgctgtg tggcaagagg tagatatgat atataacact 360

acattaagta gcatgagcat acttactgat agtgaaggta atgtatttga tagttcaaca 420

ggacaagtaa taaaattagc acctaagata taccaaggat atactgatgt agatagattg 480

ctaacgtcta ctactctata taacgagaat attacattag gttcaaatag atttatttat 540

gacttacggg atatgttact atcaagtgat acattcacag tagataataa aattaaagta 600

atagatacat acacagaagt acagtaaaga tattgacaat aaagtattaa tatgatatag 660

taaggtatgc gtattatagt ataccttgtt atattaatac agaatactag acatgaaagg 720

aataaaaaat atggctatag caacaaatgc ttcacatgta gaattagcta aatacattgt 780

aagtaaggct gattctattt atttaacaat tggtaaaagt acagcgtggt ctaatgaaac 840

aagtccacct caacctgaag aaacagcaac atcattacaa gaagttatcg gatataaaaa 900

agcaactaag gtagcattag ttagacctgc aaaaacaacg ggtgatgaaa gtaaaaaaga 960

aattacatat ggtaataaac gatgggtaga aattgactca gctaatgcag ttactgaagg 1020

tgctaagtgg gtgtacttag aaagtagtat tgttggggat gaattaccct taggtacata 1080

tagacaagta ggatttgtta tggatttgtt agctaaagat agtatttcta aatttaactt 1140

actacctagt gaagtgaaat ctacaggaac tttattattt tatgataata aacaattcca 1200

aaatagaagt gaacaaacaa ctgtaaaaga gcgctttatc attgaagttt aaaaaggaga 1260

attgaatata tatggcaatt aattttaaaa gttctccata cttagataga tttgacccta 1320

caaaagatag aacaagagta ctatttaatc cagatagacc actacaacaa tcagaactaa 1380

atgaaatgca gtctattgaa caatattact taaaaaattt aggggattct atttttaaag 1440

atggggataa acaatcagga ttaggtttta cattaactaa agataatgta ctacaagtta 1500

acccaggtta tgtgtacata aatggtaaga tacgttacta taatagtgaa gacactgtta 1560

aaattacggg tgtaggtaaa gaaacagtag gtattaaact aacagaaaga attattacac 1620

ctgatgaaga taatagctta ttagaccaaa caagcggagt tcctagttat ttttctaagg 1680

gtgcagaccg tttagaagag aagttatctt taacagtcaa tgaccctact tctgctacta 1740

tttatacttt tatggatgga gacctctata tccaatctac taatgctgag atggataaaa 1800

tcaacaaagt attagcagag cgtacttatg atgagtcggg ttcatataaa gttagtggat 1860

ttgagctatt ttcagaagga aacgccgaag atgataatca tgtatctgtt gttgtagatg 1920

ctggtaaggc atatgtaaaa ggctataaag tagataaacc agtttctacc agaattagtg 1980

tagagaaatc aagggaatta ggtaaagcag aaaatgaaag tactgtattt aataagtcat 2040

caaatagtat tactttagct aacacacctg taaaagatgt acaacgtgtt actgcgcaag 2100

tattagtaga gaaagagcgt gttacaagaa gttcaacagg agattctcaa gactatttat 2160

ctaataaaac agcttttgaa gtagttagag tatggacaga aacaagtcca ggtcagacaa 2220

caaaagaata caaacaagga gaagactata gacttactga tggacaaaca atagattggt 2280

ctccttcagg tcaagagcct aatggaggta catcttatta tgtttcatat aaatacaata 2340

gaaagatgga agtaggtaaa gattatgaag tatctacagt aggtgaggga gtaggtaaac 2400

gttggtctat taatttcaca cctgttaatg gtactaagcc tattgaccaa agtgttgtac 2460

ttgtagacta tacttactat ttagctcgta aagatgctgt attcattaat aagtttggtg 2520

atattgctat tcttaaaggt gaacctaata ttatgagatt agtaacaccg cctttgaata 2580

cagaccctga gaacctacaa ttaggtactg taacagtatt acctgattct aacgaagcag 2640

tatgtatttc atatgctatt actagattat ctatggaaga tttacaaaaa gtaaaaacta 2700

gagtagataa cttagaatat aaccaagctg ttaatgcttt agatgacggt gcaatggaaa 2760

aacaaaaccc attaacatta cgttctgtat ttagtgaagg ttttatatct ttagataaag 2820

ccgacattac acatcctgat tttggtgttg tatttagttt tgatgatgca gaggctactt 2880

tatcatacaa ggaagctgta aaccaaccta agattattca aggggatact acagctcatg 2940

tatggggtcg actaatttct gcaccattta cagaagagcg tacaatttat caaggacaag 3000

catccgaaac tttaaatgta aacccttata atataccaaa taaacaaggt gtgctaaaat 3060

taactcctag tgaagataac tggatagaca ctcagaatgt aactatcacg gaacaaaaaa 3120

ctaaaaaagt aacaatgaaa agattctgga gacataatga aagttattat ggagaaacag 3180

aacattactt atattctaac ttacagttag ataaaggaca agagtggaaa ggtaagtcat 3240

actcatatga tagagaacat ggtagaacag gtactctatt agagtctgga ggacagcgta 3300

cacttgaaga aatgattgaa tttattcgtg ttcgtgacgt atctttcgaa gttaatggtt 3360

taaatcctaa tgataataat ttgtatattt tatttgacgg tgttcgttgt gctattacac 3420

cagcaacagg ctatagaaaa ggttctgaag atggtacaat tatgtctgat gctgagggaa 3480

cagctaaagg tacatttaca attccagcag gtattcgttg tggtaatagg gaagtaacat 3540

tgaaaaatgc taattctaca agtgctacaa catatacagc tcaaggacgt aagaaaacgg 3600

tacaagacgt tattatcaaa acacgtgtta cagtaaattt agtagaccca ttagcacaat 3660

cattccaata tgatgaaagt agaactatta gttctttagg tttatacttt gctagtaaag 3720

gaggtaagtc tagtaatgta actgtacaaa ttcgtggtat gggagataca ggttacccta 3780

acaagacggt atatgctgaa acagtaatca actcagatga tattaaagta tctaataatg 3840

ctagtgctga aactagagta tactttgatg accctatgat ggctgaagca ggtaaagagt 3900

atgctattgt cattattaca gaaaatagtg attatactat gtgggtcgga acaagaacaa 3960

aacctaagat tgataaacct aatgaagtta ttagcggtaa tccatatgta caaggcgttc 4020

tatttagttc atctaacgct agtacttgga ctccacacca aaattcagat ttaaaatttg 4080

gtgtatatac ctctaagttt aatgaaacag ctacaattga atttgaacct attaagaatg 4140

tatcagcaga tagattagtt ttaatgtcta cgtacttaac tcctgaaaga acaggttgta 4200

cttgggaaat taaaatgatt ttagatgaca tggctacatc tactacattt gaccaattaa 4260

aatgggaacc tattggtaac taccaagatt tagaggtatt aggtttagct aaacaagtta 4320

aattaaaagc tacatttgag tctaataagt atatttcacc tttattaagt tctaatgact 4380

taacgtttac taccttctta actgagttaa aaggttcata tatcggtaga gctattgata 4440

tgacagaagc tccatataac acaataagat ttagttatga agcattctta cctaagggca 4500

ctaatgttat tcctaagtat tcagacgatg atggtaagac ttggaaaaca tttactaagt 4560

ctgctcaggt agttaaggct aatagagact ttaatagata tgttattgat gagaaagtaa 4620

atcaatctac taagaataac aaattacaag taagattaga cttatcaact gaaaatagtt 4680

tcttaagacc tcgtgtacgt agacttatgg ttacaacaag agatgagtaa gtttaaagag 4740

ggtttcatac cctcttttta tttaactaag gaagtgatat tatgcctaca gaatatagag 4800

acccttactc acaagctaaa ctctttattc ctactgtaga agaaaaagct ataaaagaaa 4860

tggaacaaac atataaagat aaactacaag aagttaatga gcttattgat gagcttaaaa 4920

aattgaaagg tgattacaca catgacgttt aactacacac ctctaacaga atcacaaaga 4980

ttaaaggata tgtaccctaa agtaaatgaa atgggtaaat acttaaaaga agaagttaac 5040

ttatctgatt taaaaacgat tagttatcct gatttaaata atgttttaaa tttcatacaa 5100

gactcaggtg actactttgt aacacaagca agaaacaccc cgcaaggtgt aagtaatata 5160

gggtttttac acttagataa aaagggtagt acttattata agttatatta tgctccgtct 5220

aacacaaata aattgtttgt gaaaacttat tataatggta ctgtctatga ttgggttagt 5280

tttaaactag atgaaggtac actatacgat tcaggaaata caattaatgt aaaaaattta 5340

acagagtcca caactcaatt tgcaacactc ataaaccctc ctaaaagtaa tttaaacaca 5400

ggatggataa attataagga aagtaaaaat ggtacctcag ctttagctga atttaatcct 5460

attaattcta cttcaacatt taaaatgatt agaaagttac cacgccaaga ccaacaacct 5520

aacttattaa gagatagttt attcacatta ccaatgacgg atgtagctaa tataagaacg 5580

gattatatag ataatacatc tttttggggt tttactaata atgcatctac ctcaacagtt 5640

agatatatgg gtgaaaatac tattcaatta gatgatggag gggaatcata tcctacagtt 5700

atgtcaaaac gatttagaat aggagacgaa ctatatgtag gagatactgt tacaatgtct 5760

gtttatatta aagtaaatga ccctaatttg ttaaatggta atttccccta ctttgagatt 5820

gctgggtata attatgttta tcaagacaat aacccataca caggaggtag gagagaggtt 5880

aactattatg acttatctac ggagtggaaa aagttctcct ttacttttac tttacaatca 5940

tataaccaag agtctagtaa tgatagggtt aattatatat cagccctact aagatttaac 6000

tgctctaatt ctactagtaa tggagctatt gtgtattatg cactaccaaa attagaaaaa 6060

tcatactcgg taactccttt tattactcat acttatgata aaagaaaata tgatgaaata 6120

tggagtaatt ggactgagac aacaagtaaa gatgagcttc aatcacacag tagcgtagat 6180

acatatagta atgactacta taaatacgta tgggattacc aaagttcgaa tggtagaagt 6240

ctgcaacaat tagcaatgtc tgtacctcaa ggtttttata ccttctactg tgatggttct 6300

ataagtggaa ctcctagtaa taaaacaata caaggcacaa tacaagtagc gtataaaaat 6360

aataatataa acactacaaa taaagtaata caaatggatt ttagtgatac taaaggcaag 6420

aaatattctt taacatataa taaagataat aacggttggc aagccatgaa agttcaaatg 6480

gctagtaata gcctttggga aggaacgctt gaccttgctt caggaaacac agtaaatcta 6540

tcagattcgt tagataacta tgattttatt gacgtagtat attggactag aagttctgga 6600

cataatgcaa ctagaagatt ccctgctact acatctagta ttgtaattag agactttaac 6660

ttagtaaatg atggctctaa ttctagcgta gatttctttg aaggatattg cggcattact 6720

gataagataa acgtcactgc taaaatgtca aaaacaatta acctagatgg aaatagaaat 6780

accacatcag tagcacaatt caaccagaca ggtcacattg aagtactaag agtaataggg 6840

ttaacatata tttaagagaa gaggttttat agatgataaa gtatgacatt ggtaaagatg 6900

aaattgtgtt acatttagaa gatagtaagt atatcatggg ttacactatt gttggagggt 6960

atgatgagaa caacggtgac gtaaaaattt ctaggtcaat tcttcctgac gggtttttta 7020

ctgagtttgt tagtactaag tatgtatact ataagaatac taacgaagta atatataaca 7080

aaaattttaa ggataatgct aagagtattg aagatgctga ttaccaacca cctaaagagt 7140

atgttcctaa agaagattat aaaaagctag aaagtgaagt agaagaatta aaaagaatgc 7200

tacaagaatt gttatctaag aaaggataaa taatatggca ctaaatttta cacctattac 7260

agaaaatagt acaatagcag atttaacaaa acaagttaat aatataggtg gtgtactaac 7320

tgaggacaga aatgtctttg aagtaacaac agacttacaa gcagatgtaa gtagaacaca 7380

gaaagttaag ttaacaacag atagagggtt agctaaagat attgattata ctaattactt 7440

aagagatatt agaaaggtag gtctatatta tataggagct cgtacattag ctactatgta 7500

tgataaacct gatatggaaa acatggatgt actacttcaa gtactaacct tagatactga 7560

ggatagagta gtacagatat tacatacatt atctaccgct gattctaaag taaaagtact 7620

atataggttt gttaacaatt atcaaacatc acaatggcaa gtagtacaaa gtctaccaaa 7680

taataaatac acatctcaaa taggtggaag tccttttgat attaacacac aaggtatata 7740

ttatgtgtct agtatgtcgg atatgccaaa tggtgtatat gaagggtttt tacaggttat 7800

tatagacaat aatgaaaata gaatgttaag attaacggat attagcacag gaaaagaata 7860

tcttaatgtt aaaaaatcgt atggtagctg gggcacatgg aaaactgatt tagatgtaca 7920

aaaaataagt aagtatttat tatctaatgt agatggtgat gctgaaagta ataactactc 7980

tttatctgta tatactacag acaacataac atttcaacag gcaatagcta aacatattga 8040

agaaacaagt aaaactgttt ttacttttta tatacaaggg ggtgttgtag ggtctccgtc 8100

ctcagttagt tgtagaggtg tattcatatc agattcaact aactttacta acctatatgg 8160

tgtttatact gctataggta ctgatggaag aactattaat ggttctgtaa atggtaatac 8220

atggaacaca acaaaaacac taccaggatt taaagagctg tggaatggtg cacataactt 8280

taaagataca aataaaaaag aaaccatgtc tgattctata tctaactacc agtatgtaga 8340

agtatacaca agatatagag ctctacaaaa tacaaaaggt actgataaaa caggtacact 8400

atgtcataag ttctatatag atggagacgg tatttacaca tgttcaggag cttatgtatc 8460

aggagactct aatattggag tagagtacta tcgagtaact ttatctatta ctggtgatac 8520

ttggacaatt aaagatagtg cagtaaataa taataaagac caatatgtta cacgtgttgt 8580

aggtatctct ttaccataga ctaggataat tcctagtctt ttttttcttg actaacttta 8640

ataaatatgg taagataata aaggactaaa aagaaaggag aatatatgca gttaagacaa 8700

cagaatatat atacatatgt agattttgat gaaagtgacg ggtatattaa agatatcata 8760

cttaagcgtg ttcataaaac gttaggagct aagaaagatg gctatcaaca tagcttagct 8820

tttaaacgag gtgtgtggga tggttatgta gatttctatg attatgctga gaacaaattc 8880

cctagtgggt tgttacctaa gatgataaca ttactaggtg agttacaatc aagacataac 8940

tttcaatacg aaattattga tgaaaaatct gaaagctttt tagctgaaga agatattgat 9000

gatgaaatac agctactaga taataacgta ggtaagatta cattacgtga ctatcagtat 9060

gaagctgtgt ttaatagtct agtcaattat aatggtatat gtaagcaagc taccaatgca 9120

ggtaaatttt gccccttata gtagaaatat tataagtgta actcctttaa ttcacggaaa 9180

ctctctcatt tgagacaatc atgagccaag cttagtaaat atcaggaagg tgcaacgact 9240

attatgtaca atcaagtggt tggaaacagg gagaacctaa gtctcattag atatggttaa 9300

gatatagtct gaactttgta ggagactaca agaaggttag gagtaacgaa cctaatcgta 9360

acaaaattga aaacagaggt tgctagcggt atcatagacc aactattacc acaactagaa 9420

aaaggagagc gtgtagcttt ctttacaagc tctaccgaga tttttaatca atctgctgac 9480

cgtttaagtg aacgattgaa tataccagta ggtaaagtag gttctggtaa gtttgatgtt 9540

aaacaagtaa ctgtagttat gattcctact gttaactcta acttaaaaga ccctacagaa 9600

ggagtaaaag tatctgctaa agtaaactta agtaaaaaga tagctaaaga gatacttcct 9660

aaatttgaag gtggtaaaaa tcaaaaaagg ttacttaagt tattattaga aagtacaaca 9720

cctaaaacta aagtagagca gaatgtgctt gatatacttc aagatattta tcataattca 9780

aagacggatg ctgaagtatt aatggcatta aacaatcata atgttatttt ccaaaaagaa 9840

gtaagaaaga aaaatcaaaa gagctatgat aaatatcata aaatgcgtga gttcctagac 9900

tctatagctg taatgatagt tgatgaagca catcacagta aatcagattc atggtataca 9960

agtttaatgt cctgtgagaa tgcattatac aggatagcat taacaggctc catagacatg 10020

aaagatgagc tactatggat gcgtatgcaa gcattattcg gagatattat tgtaagaaca 10080

tctaatgagt ttttaatcga gaatggctat tcagctagac ctacaataaa tattatccct 10140

attgctaacc ctgatgatat agataatatt aaggattaca gggatgcata taataaaggt 10200

attgtacata acgagtttag aaatacactt attgcaaaac taacagctaa atggtttaat 10260

caagataaag ctacacttat tattattaac tttgttgaac atggtgagat actatccact 10320

atgttgaatg aaatgggtgt agagaatttc tttttacatg gtgaaataga gtcagatatg 10380

cgtaaacaaa agttagatga aatgcgtaat ggtaaactta aagttatgat tgctacaagc 10440

cttattgatg agggtgttga tatcagtggt attcgttcat taatcctagg tgcaggtggt 10500

aaatctttac gacaaacact acaacgtgta ggtcgtgcgt tacgtaaaaa gaaagaagat 10560

aatacaacac agatatttga ttttaatgat atgacacata agtttttata taaacattct 10620

aatgagcgta gaaaaatata tgaagaagaa aaatttgaaa ttaaagaatt aggaaagtag 10680

gtatgggtag tgactaagac agaaagaaga ttatatgatt acattgaaaa aaaatcaaaa 10740

aataatactt atcaaatagc tactaaaaaa gagttagcag aagagctaga tgtctcagtc 10800

tctactttat ctaaaaacct taaaagatta gaacaggata acaaaattaa tgttgtttct 10860

aaaagaggaa ataaaggtgg tattgttata tcactagtaa gagattatga tacagatagt 10920

ctcttacatt ttaatgctac agatgataat gttattactt ctaatctaga atacgctact 10980

gaattacgaa atagattttt tcctagttac gtatatgaaa gaaaagaaaa taaacgtaga 11040

acaaaactag aaatggttca atataatgct attaaagata aaaacaggaa aataatatca 11100

aatatgaatt tttatagtag tagcttacct taccctacta aagatatttt taatatgtct 11160

tatgaccctg agggttttta taaagcttat atattatgta agttatatga ccaatatgct 11220

atagcacaca tgaatgctaa atatatacaa catttaacat tatcaaatgg taatgaagac 11280

gtagatagac ataagcattt atctgagtac tacagaaaga aaatgttaca gaatttatca 11340

cgagatagta tttgtaaaga cttctttggt agtaagacat ttaatacatt ctacaacttt 11400

tacttaaaga taaaagataa gaacattaat gtttttaaat acatgcaaaa tgtttttaag 11460

aataccacat ttgggtttga gaataaaaca caaccttatc ctatacctgc acctaacttt 11520

tttagttcag ataaatatct aactaattat gaaaattatg taaaaggtat taaacgtgga 11580

gtaaataaaa caaatagaca agtaggagaa gtagaatctt taattaagtc atctgattac 11640

ctattaaatc ctgctgtagc acaattacat caactatata caacaccttt aaatgaagag 11700

atacatgata ttgatacaat gtttaaaaca gctttagata tagaagatac tatttatggt 11760

atatttaatg gcatgaaaca tattatactt ttatcatata ataaatatat agaacatcta 11820

atagaaaaat tacctagtaa acataaaaac ttattaaata aatttattaa acaatgtatt 11880

gtaaatgagt attcacctac tacaatacct aacaatgcta gactatctat gtttttaatg 11940

caaaaagagt ataaagcaaa tatcgcagaa ttaaatggtg gtatagatag aagagactta 12000

ataggtataa gtttagtaaa cactacagac ttaagtaaac aagatattgt aaatatagaa 12060

caaacaacaa tgaattatct acatatgaga agatttactt caacatcata tattctacaa 12120

atgtatagta attatttagg atatgaggtt aatttaacag aaattaagac tattattgaa 12180

aagtataatt tatttaatga aataccattg acaaaagaag gtatgataga atacaataag 12240

gttattgata tagtaaagga tgacacatat gagtaaacga attaaggaga ttatcctaca 12300

taagtctatg aaggatatac attttgcaag agaagtacta gataagttac ctaaaagtct 12360

atttgctaca gaatcagaag acatgggtta cttattcaca gctataaaaa gaacagcaca 12420

cattgctgat aaaatgtcaa atgaatcttt agctattaaa gtagagcaat taatgggtag 12480

tgataaacaa gatgatgaaa aagtaacaca aacattaaaa tatttagata gcttatatac 12540

agtagacatg aataataaag acgattctgt aaactatgaa gtagaaaagt atattaaaac 12600

agaaatgtct aaagaagtat tagttaagtt catagctgag aataagcaag aggactcaga 12660

taacttacct gaactagtag agaaactaaa acaaatagaa gtcagtgaca ttaatggtac 12720

tgatggtgaa tttattgatt tctttgaaga cgtagataaa aagagagaac tattaagtaa 12780

cttaagtatt aataagtatt ctacaggttt ccattctata gaccagcaaa ttgaaggtgg 12840

tataggtaga ggggaagtag gattagttat tgcacctaca ggtagaggta agtctcttat 12900

ggcaagtaat ttaggtaaga actatgttaa acaaggttta aatgttttat atattgccct 12960

agaggaaaag atggatagaa tggtattaag agcggaacaa caaatggtag gtgtacaaaa 13020

gaatcaatta cttaatggtg acttatcttt aaacacagat gcttataata agatacaaga 13080

acactataaa aagaatagac aactgctagg taacttttat atcgttaaac atatgcctgg 13140

tgaggtaaca ccaaaccaat tagaacaaat tatagttaat acaacaatta agaaagataa 13200

gcatatagat gttgttatta ttgattatcc taaacttatg cgtaaccctt accttaagta 13260

tcaaagtgaa tcagatgctg gtggtcgtat ctttgaagat attcgaaaat tatcacaaga 13320

atacaatttt gtttgttgga cattagcaca aacaaacaga acagcttacg gttcagaaat 13380

tattacaagt gagcatgttg agggaagcag aaagattgtc aatgctgtag aggttgcttt 13440

tgccgttaac caaaaagatg aagaatttaa aaatggtttc ttaagattgt acctagataa 13500

agtaagaaac agttcaaaca caggtgagag atttgttaat cttaaagtag aacctactaa 13560

aatggttgtt agagatgaaa caccagaaga gtcagaagaa cataagcaaa tactagcgga 13620

acttaatggt gaagataaga gtagatttaa agagaagtct aataaagcag aagttattaa 13680

taattctttt ggaggtgtga gtttctaatg gacgatttta ctaggcttta taaaaaagta 13740

cgtagaacat ttacacgtaa taaagcagaa tgggattaca caaatacagg attaagaacc 13800

ttccaattaa aaggaactaa tgtatgtgtt acattactag actctatagc aaggaataat 13860

acaacaggat ataagtataa cgttatgtct aataaagtac ctgctatacc ttgtaacaca 13920

caccaagaag taattaaagc aattgaatat aagttaaaaa attgagaaaa agccttgaca 13980

atgtatttgt taaggcttat acttttatta taaacaataa agaggtggta agatttgaac 14040

ttaaatgaag caaaagtaaa attaaaaaac tttaaagtca ttaataagca cggatttata 14100

gagactataa acacaaagta ctctgaaaag gagttagagg atgtatcaac cgatatattt 14160

aatacattgg ataattacgt aatagataag tatggttgta aattgtttaa tattaagcct 14220

aaaagaagta ttatagagtt agaattaaca aacaataaaa ttaaacattt aagaaagtag 14280

ggtattaaca tggaattaga attaaataaa atctataacg aagattgttt agaaggtatg 14340

aagaagatac ctgacaatag tgtagactta attgttacag acccccttat ttaattaatt 14400

atagaaccaa gtggagaaaa aataaagaac atagatttgg aaaagttatt ttaaacgata 14460

ataacgaaca acttattata gattatataa atgagtgtta caggttacta aaaaacaata 14520

gtgccatgta tatgttttgc tcatcagaca aagtagattt ttttaaacaa caattagaga 14580

agaaatttaa aataaaaaat atgattatat gggtaaaaaa caatcataca gcaggagatt 14640

taaaaggttc ttttggtaga aaatacgaaa tcttattttt agtagtaaag ggcaaaaaac 14700

attttaatgg gagaagatta actgatgtat gggaatttga tagggtaagt ggtaaaaaac 14760

aattacacca aaatgaaaaa ccattagatt taataaaaca atgtattatg aaacacagtg 14820

atgaggatga tgtagtgctc gatggtttca tgggctcagg tactactgct attgcttgta 14880

tgagtactaa ccgcaattac attggttttg aattagacga agaatactat aatttagcca 14940

gtgaaagaat agaaaaacat aaggagatac taaacaatga aaatgacaat acaggaacta 15000

caagataaga ctgaattttt aagacacgta aaggtagata cggaagaagc aatggatatc 15060

cttgaagata tattaagagg agagccttac acagatgagg tatgtgaatt gatacatttt 15120

tattcaagta agctactaaa tgagattaat gacaatcata tgtttaaatt acaggagttt 15180

gctaatcatg atgttataga aattagtgaa gagggagtaa aataataata aaattattac 15240

agggggattg cttagagtta ttagatacaa ttgaagatag tagtgtagat gctattatca 15300

cagacccacc atacaatatt gcaaaagaga acaggttcac aactatgggt agagctggta 15360

ttgattttgg ggaatgggat aaaaattttg aagctacttt atggattaat aaagctatac 15420

cgaaagttaa aaaaggcggt aatatcgttg tgttttgtga catgagacaa ttcacaccca 15480

tcattaatac tatggaagac ttaggctgtg aatttaaaga tgttattcgt ctggaaaaat 15540

ctaaccctat gcctcgtaat agggatagac gatttatttt tgatactgaa tttgctcttt 15600

attttgttaa aaaaggagct aaatggactt ttaaccgttt agatgaaaaa tatgaaagac 15660

cttgtattaa aacaagtgta acacctagaa gtgaaaagca gggcaaagga cacccaacac 15720

agaaaccttt atatgctatg gaatggttgt tagagcgctt aactaatgaa gaagacattg 15780

ttctagactg cttcatggga agcggaacaa caggtgtcgc atgtaaaaag ttaaatagga 15840

attttattgg ttgtgaatta tcagaagaat acttcagtat ggcacaagat agattactaa 15900

ataatacaaa ttaaaacaaa acccttgaca acatgtttgt taagggttat acttttatca 15960

taacgtacta aaggaggaca ctaatgaaat ttatattttt tacagatagc cattttcata 16020

tgtttacgaa ttatagtaaa cctgatgaag aatatggtaa tgatagattt aaagaacaaa 16080

ttgagacatt acaaaaagta tttgatttag ctagagaaaa taaagctaaa gttatatttg 16140

gaggagattt attccataag agaaatgcgg tagatactag agtatataat aaggtatttg 16200

aaacctttgc taagaatcaa gatgttaaag tatatatggt tagaggaaat catgatgctg 16260

tgtctaattc tttatatacg gaatctagta ttgatatctt tgaaacatta cctaatgtgg 16320

aagtaactaa agatttacgt agtgactcac tttctagtaa agtacaatta actatgtgtg 16380

cttatggaga tgaaacagaa gaaattaagg agtatattaa aaaatcttac caaaaagata 16440

aagtaaatat attagtagca catttaggcg tagagaatag tttaacaggt aaaggctcac 16500

acagattaga aggtgcattt ggttaccaag acctattacc agaaaaatat gattttattc 16560

ttcttggtca ctatcataga agacaatatt taaacaataa ccctaatcat atgtatggtg 16620

gttctctaat gcaacaatcc ttttcagatg aacaagaagc taatggtgta catttaatag 16680

atacagataa gctaacatca acgttcattc cattagatac tagaaagttt attacagtgc 16740

aaggtgacaa tgtaccagat aacatgaatg atttagtaaa ccaaggtcac tttattaggt 16800

ttattggtac tccagaacaa gctaaagtaa ttgaattaga taaaacagaa gatgaatcta 16860

atgtacaagt acaaatgaag aaagaataca cggtagaaaa gagagtcgac gctgacgtgt 16920

ctgacagccc tataacgatt acttctagtt atgcagacaa atactatcca gaagcaaaag 16980

atgagcttct agagtgttta aaggcggtgt tgtagtatga tagatattat tataaagaat 17040

attaaaccaa gtatagataa atctaaacct attttacagt tcttacataa taaaagaaca 17100

tatgatgtat gtaatgttaa aaatattgat gatgcgatgt atcttattaa caaagtacta 17160

gaggaagcta actacgctca ttattatacg agggttattg aacaagaaga ttgttatatt 17220

ctagattatg gttcacatca atgtttcttt aaattgttaa aagaaggtgg tacaaatggt 17280

taagtttaat tatgtagaga tgaataactt tttagctatt gagcatatca agctaaatct 17340

ggataagcaa ggtcttgtac ttattgaagg tattaataaa acaaatgata gttttgaaag 17400

taatggaaca agtaaaacaa gcatgatatc ctctatcaca tatgcactgt tcggaaagac 17460

tgagaaaggt ttaaaggcag atgatgttgt taataagtat aagaagaaag acacctacgt 17520

taagctttct ttcaacatag gtaaagacga gtatttaatc gaaagatatc gtaaacacaa 17580

ggaacacaag aacaaggtta agctgttctg taataacaaa gagataacag gctctacaaa 17640

tgatgttacg gatactcaaa tacaagagtt atttggtatt ccttttaata catatgtaaa 17700

tgctattata tatggtcaag gagacattcc tatgttttca caagctaccg acaaaggtaa 17760

aaaagaaata ctagaatcta ttactaagac tgatatttat aagcaagccc aagaagtagc 17820

taaagaaaaa gttaaagaag tagaggagaa acaaagtaaa gaacaacaag aaatagaaaa 17880

actagaatat aaaagaaacc taaaacaaga acaatataat aatgaagtaa ataaatataa 17940

taacttatta gagcgtaaga agcaagaaga ggaacagttt aatcaaaaga aacaagagta 18000

cgagaataaa ttaaaagatt tagacaatca gattggtgta tgtaaaggta gtattcctaa 18060

agttgaagac tttgaatttg tatttagtga aaattataca aaagctaacc aaggtattga 18120

aaagattaac acaaatatta atgataaatt attgccatta ttgagtcaag aaacaacaaa 18180

taagaataca actctaaata taattaatca attaaaacaa tctattaata aactagatac 18240

aaatgaccat tgtcctgttt gtggttctcc tatagataat acacacaaaa taaaagaaaa 18300

agaaaactta gaattacaaa ttaaagaaaa acaagctaaa atatctcagt acgaacataa 18360

tgagcagact ataattaata agaaagaaga gctactagct aaatctaaag aattacaaca 18420

atttatacag caagaagata tagaaaagaa aaaacatgat gatgatattc aacggcaata 18480

cagagaacag caagaagtat atgatgaaat tagccaatta gaaaacacta aagctaattt 18540

aaaagaacca atattaaatg attactctta tatagaagaa cctaatgaag aattacacaa 18600

taaagaacta aaagatattg acaatactat tgacaaacat aaggaaaata tagtacaatt 18660

agagagtaag aaaacaaaat ataaacaagc tgtagatgca tttagtaata aaggattacg 18720

ttctgtaata ttagacttta ttacaccgtt cttaaatgat aaagctaatg agtatttaca 18780

aatattagcg ggttcggata tcgaaattga atttcaaaca caagtagaaa atgctaaggg 18840

agaacttaaa gataagttcg atgttattgt taagaataac aatggaggag agtcttacaa 18900

atctaattca gcaggagagc aaaaacgtat tgacctagct attagttttg ctatccaaga 18960

cttaattatg agtaaagaag atatatctac aaatatagcc ctttacgatg aatgctttga 19020

tggtctagac actattggtt gtgagaacgt agttaaacta ctaaaagata gactaaaaac 19080

agtaggtact atttttgtta ttactcataa taagagtcta gcacctttat ttgagaatac 19140

aattacggta gtaaaagaaa acggtgtagc tacactaaga aaggaattaa ataatgaaac 19200

taaagattaa agataaccag tttgcatctt taacagtaaa ttatacaaac aatgcaaagt 19260

tacatataga tagtattcct gtttctactt tagtagactg gtacccttta agtaatgcat 19320

acgagtataa agctagtaat gactttggat atattgagtt aaaaagatta cgctctagtt 19380

tacctatgtc ttatggatta acacaccgaa ctttatataa atgtgaaact gttaaatgta 19440

aactaggatt atggtataac gaaaaaataa aagaagataa tgagaaaatt attgagaaag 19500

ctaagttgta cggtttacct actatagatg aacccttcac aagtaaagat gtaaagcaag 19560

gatttagtga cttaggtgtt attttccaaa cactaaaaac aatcagtaca aacgagtact 19620

tgaaagataa aacaattgaa gagattaaca cctttagtaa gaaatcagag gattatcaat 19680

taaatgaagt actcaagtac agtacaacac tggtagatga tacttatagt gatttaagtc 19740

aaatctataa tatgttactg ttaatgaaga aaattgtttc tatataggaa gtgactgaaa 19800

atgaggtttg aagacttttt aagtcaagag attggaacac ccaaagagaa tactgtagga 19860

gaattacgat attgttgtcc tttttgtggg gaacagaaat acaagtttta tgttaagcag 19920

tctttagact ctactaatgg tatgtatcat tgtaagaagt gtggagaaca tggtaaccct 19980

attactttta tgaaatctta ttatagtatt acaggtagac aagcttttga gttattagaa 20040

acaaagaata ttgatataca attctcacca acattagaaa tatataacac agatttaact 20100

gaaagtgaga aattattact aaggcttaat ggatatacaa aagataatag tagtataaaa 20160

tcaaaagcac ctgaactacc tatagggttt aaattgatta aagataactt aaataataaa 20220

gaagtagtac cgtatttaag atatctcaag aatagaggta ttacactaca gcaaatccta 20280

gactacagta tagggtatat tataaatggt tattgctatt cttatggtat taataatgag 20340

aaaaagaaaa tagtacttag aaatagtgtt atatttttta cttatgacaa tgaaggtaag 20400

tatatatact ggaatacaag aagtattgaa acaaatccat atattaaatc tataaatgca 20460

ccttctaaac ctaatgagta tggtaaaagc gatgttatat ttaatttaaa tatagctagt 20520

aaacaaaagt ttgttgttat aactgagggt gtttttgacg cccttacatt tgataagtac 20580

ggtatagcta cgtttggtaa acaagtttca aagatacaag ttaataacct catttcaagt 20640

attcctaaag aaacacctat atatattatg ttagatacgg acgctacaga ctttagtatt 20700

aatttagcta gtaaacttat tatgcatttt aatgtagtat atttagtacc tcatggtaat 20760

gaagacgcta atgatatggg tatggaaaaa tcttttagta ctttgaaaca caatagattt 20820

ttagttacac ctgaaagtat tcaaagttac aaactacaac aaaagttaaa actttaatct 20880

tgcattataa tgtatagtat gttacaatac atatataaaa ataaaggaag tgttattttg 20940

gaagagaaag atattctaca ttttgtagat gagtatgtta cagcattacg tgtaggtaat 21000

gaacagcgta tgcaccaatt agaagagtta ggtaaagaac aaacagcaac tttaacagat 21060

gtaatgaagg ctattactaa cttattgtta ggtgttaata aacaaatggt tgacctagag 21120

caaaatacag agttaaactt aaacattcta attgatgctt tatataaagc tgagttagtt 21180

aatgatgatg tattaaaata tattgaggaa gcaattgaag aatcaaaaga aaaggatgaa 21240

gaataatgga aaagaatatt agtacccata caaaaggtat ttcacaaaaa gatatggaca 21300

tgtggttaga agccgtaaca caaggaacag tagaaggcaa ggaattaact gaggacactg 21360

ctaaacaatt acatcgtatt ggagcacgta gtgtatctct agatgaggct actagaattg 21420

cacgagcaat taatgccgtt acagttcaag agtatgcatc tgcctttaat gatgctttta 21480

atgctattga tttattaatg attgttatgg aagataacct agatgtaact actgagcaag 21540

tagagaaggc gcaacttaaa ttaaaagaaa aacgtgaaaa gtatttagaa gaaaaacaag 21600

aagaagtaag aaaaaaacaa gaagagcata aagcaaaaga agataatgaa aaagtagtgc 21660

agttgaagaa acatgacaaa tagtaaaaaa aaaggtgatg tattcgaaag aaagattgcc 21720

aaagaacttt ctgattggtg gggttatcct tttagtaggt ctccacaatc aggaggtgca 21780

tcatggggag ctaacaataa tgctgtcggt gacattgtag cacctttaga gtctaatttt 21840

ccattagttg tagagtgtaa acatagagaa aattggatta tggataatgt tctacttaat 21900

aataaagaac ctcatacatg gtgggaacaa gttataggag atagtttgca agttaataaa 21960

actccttgtt taatatttac aagaaataga gcacagtcat atgtagcatt gccttatata 22020

gaagatgtat atgtaaagtt aagagatgaa gagtacccta ttatgagaac agattttatt 22080

atagagaatg ttagaaaaga caaacatttt tatgatgttc ttataactac gatagatggg 22140

ttgactaact taacaccttc ttatattata tcttgctaca acaaaaaaga gattaaacca 22200

tatagagttg tcaaatctaa aatatctaaa gttagtaaaa aagaagataa gttgattgat 22260

gatttacttg atggtattta aggaagggat attagttgat tacacaaata aaaaaacgtg 22320

atggttccgt tgtagattat gatttaagta aagttactaa tgctatttta agagccaact 22380

cagaaacaga agaatatatt gaagatgtta ttgattctct tgtagatgac gtagattctt 22440

tactagaaga acaaaatact atcattactg tagagttaat acaggatata gtggaagaag 22500

ttttatttag tagtatgtat aaagacacag ctaaagcttt tattttatat agggataaaa 22560

agaaaagaga gcgtaaaaga gacttattca aaccaagaaa agaattaaag ccctatgaat 22620

accctgaatt gttagaatat aaagatgcta tacgccaaag ttactgggta cacactgagt 22680

ttaactatac atcagatatt caagactata agaataacgt taaatacaat gagcaaatga 22740

ccattaaaaa agctatgcta gcaattgccc aagtagaagt agcagtaaag actttctggg 22800

gtgacctata tcatagaatg cctaaatggg aaactggagc tgtgggtgca acttttagtg 22860

agagtgaagc acgtcatgcc gacgcttatt cacatttatt agagatttta ggtttgaatg 22920

aggagtttaa aacaattgac gatattcctg ctcttaaaga acgtgttgat gagttagcga 22980

tgcatgtaaa actaagtaag agtgaggatg atagagatta cgtactatct gttttattat 23040

tttctatatt tattgaacat gtatctttat ttagtcaatt tttaattatg atgagtttta 23100

ataaatataa aaacttattt agaggtttat caaatgctat tgaagctaca tctaaagaag 23160

agcaaatcca tggattattt ggaacagaaa tcattaatat tcttagagaa gaaagacctg 23220

aatggttcaa caaagaaatg gaagatgcag tttacacagc ctgtaaaaaa tcttatgaat 23280

cagaaacacg gttacttgat tggatgtatg aagatgggga actagagttc ttacctaaga 23340

aagtagtaca agaatttatt aaaaatagac ttaataactc tctagtagct gttgggtata 23400

ataaactttt tgatgttgat gaagagttac taagtgaagt gtcatggttt gatgatgaag 23460

ttattagtac taagttaacg gactttttat ctaaacgttc tgtaaactat acaaaattta 23520

gtaattctgt aacggaagat actatttttt caacggaatc tgattttgaa aatactggta 23580

aacgagttac taaagataaa gtaaacgcta ttttaagact aaaaatgata taaaggcagt 23640

gtatatagat gagtaatttt gaatggttaa ataatgattc tagagttttt ctagaacgtg 23700

gttatttaag tgatggtgaa acaccagaac aaagaattaa agatattgca gattatgctg 23760

aagatatttt agatattgat gggttttctg acaagtttta tgattatatg agtaaaggtt 23820

attattcctt atctagtcct atatggtcta atttcgggaa agatagagga tttagtatta 23880

gttgttttgg tagttgggta gatgatacta taccatcgat acttaatact gctagtgaag 23940

taggtatgat gagtaaatac ggcggtggta caagtggtta cttcggtaat atcagaccta 24000

gaggctcaga aatcactgat aatggtgtaa caagcggttc cgttcacttt atgaagttat 24060

ttgagcaaat gacggacaca ataagccaag gatgttatga tgataaaact gaaatactca 24120

cagagaatgg gtatgaatta ttatctaatg tagttagtag aaaagatgga acaaaaattg 24180

cacaggtaac agataatgat gaaatagagt ttgtagagcc tatagattat atggaatttg 24240

tacctgaaga taatgaatta gttcatttta aagatagtaa aaatattgac ttattagtga 24300

ctaagaacca taatatggtt tttaaataca gaactaaaag gactaataaa gaaacaggaa 24360

aaagagaaag tgttttagta cctgagtata gaaatagatt agcagaagat atgccattac 24420

atagagacgt ttatttagca cattcttcat ttgctaaaga aggcagagga ctcacattta 24480

aagaacgtct tttggtagcc ttgcaagcag atggtagtat tattaaaaaa taccctaaat 24540

ctttgaagtt tagatttagt aaagaacgta aaaaagatag actattatgg atattagatg 24600

gtctaggagt tgaatacaca tataatgtag acaaagacaa taatcataat atttatgtta 24660

atatgggtga agaattacct aaagaattta gtaaatgggt aaatttacaa aatgtcacac 24720

aacaatgggc ttatgatttt attgatgagt tgtctcattg ggatgctagt agaagaacgg 24780

ataaatcatt tatctacatg agtgtggttg aacataatgt agacattgtt caagccatag 24840

cttctatggt aggttataaa tctcgtaaat cagttgattt aagggaaaga gaacctaata 24900

aagccactat gtataaaata tatctatctg aaggtcaatt atttggaggc tcaaatatta 24960

ctgtggaaac ggtacaatat aaaggtaaag tatattgtgt tgaagtacct actcataaac 25020

ttgttgtaag aaggaaaggg catacattag tttgtggtaa ttctacacgc agagggcgtt 25080

ttagccctta tctacctata gaacacaaag atattgacga gtttttagag attggtaccg 25140

aaggtaatcc aattcaaaac ttaacacatg cagtaacagt tactgatgat tggttattag 25200

acatgattaa tggggacaaa gaaaagagaa aaatatgggc taaagtatta acaagaagaa 25260

cacaaatagg atacccttat atcttctttc atgataatgc aaatagtaat acagtagatg 25320

tatataaaga caaagggtta actattaata actcaaattt gtgtaaaaat ttgcaccttt 25380

agtaagtaat tactatcgaa aaatccatct aaacggtgaa tatctaagtt aaaatatacg 25440

acaacaccgt gctaaatcag attataaatc tgtaaatgcc taacgactat ccgtaaccta 25500

ttcacataag tgaagggata aggttagagc caagtggtat aagtattgag taataatcaa 25560

gtaaatctta tttaaatcga aatggtggac ttccttatta aggaagatga tatagtctgc 25620

tctatatgga aacatataga agttcatatt aacaataata attaagaggg tcgaaaatgg 25680

agtaccatat ttataaaatt acaaacaaaa acaataataa aatatacatc ggaattacat 25740

caaaaacagt tcaacataga tttaaaaatc atattagaaa agctaagata ggctcaacaa 25800

ctaatttaca ccaatcaatg atgaaacatg gtgaagagaa tttttatgta gaagaattat 25860

acacttttag tacagaggat aaaaagtttg cttacatggt agagcaaatt tttatagaca 25920

tgtacgaatc tgtaaaaaaa ggttataata tggagatagg ttttgggtgg aatataatgg 25980

atagacgagg aaaaaacaat ccgatgtatg gtaaagaaag cgctaatgct aaaaaagtta 26040

ttgttgatgg cgtagtttat aaaaatatgg gtatatgctc tgaagagcta ggaataaaca 26100

gaaatacatt aaccagaaga tgtaattctg aaaaattccc taactataaa tattgttaat 26160

tagagaactg gtagtgatta acgaccacta ttgaacatgt aggagtgaaa ttatgttacc 26220

taataaagaa gattggtcat ttgtatgtga cctatctagt atgaaccttg ttaagtatga 26280

tgaatggaaa cacacggatg ctgtagagac acttgtttac tttttagatg ctgttatgtc 26340

tgagtttatt agagacttag aatatctaag agactcagct gaaaaagata aacaagaagc 26400

atttaaattt atggagagag cttataactt ttctgttgag aacagagcct taggaatagg 26460

cgttcttgga tatcattcat acctacaatc aaaactcata ccttttgaaa gtattaaagc 26520

tagtcaaatt aatgaagaga tatttaaatt attaaaagaa aaaacttata aagctagtga 26580

gcagttagct aaactttatg gagagccttc tattttaaaa ggttatggta gaagaaattc 26640

atgtttgatg gcggtagcac cttaatttat agggcgtata tggattaaca tatatgataa 26700

cactcttgaa tttctgaaaa gcctaagtgt gtaaacataa ggtaatcaga agctaagatt 26760

tatttatagc taacttgaca aaaacaaata tatacattat actagttact aagaggtgat 26820

aataaatgtg gaaaaatagt attagttttc ctaggctcga agtaactaag gatggaagag 26880

taagaatgtg gaataaatca tggaaaagat atgtagaaaa aagacatagg tatgataaag 26940

atggttactc aataatttct acaagaaaag aagatggtac atccacatca gcaagagttc 27000

atagattagt agcagaagcg tatataccaa acccatacaa taaacctgtt gtaaatcata 27060

agaatgggat taaagatgat aatagggttg aaaatttaga atgggctact atatcagaaa 27120

atactaaaca tggttatgat gttttaggtg ttaaacacgc taacgctcaa ctaattttag 27180

tctacttaga tggcaaacct ttttctagtt atgactcctt aactttaatg ggtaaaacat 27240

taggtataaa tagaaatctt atacgtagag tagaaaaaga aactgatggg tacatctcat 27300

ttaaatggat agaaaaacca tataaagtac acaataaaga tttttggaaa acatcaagaa 27360

aattaaatac gagaggctct tgttatgttg taaataatgt atactataat agtgcaaaga 27420

aagctatgga ggctcttaaa gtaagacaag atgttttcta taatagactt aaaaaagata 27480

aaaatgtata tagtgtaagt attaaagagt acttaaaaaa ctgtcaagat ataaatagat 27540

aaagttcaac gactatcctg ttgcggggag tacactcaag tgagtggaag tgggagtggt 27600

cttacattta gtaagatgtg atatagtctg ctctctatgg aaacatagag ctgttattaa 27660

attaacgcat gtaaagtaac gaactacatg gaacataaag gacaacaagt tcgtcattta 27720

tcctaggtca agtttctaaa tcaattgaac cttttatgag taattattac gttgtagaca 27780

ctgctaaagt aaagaaaact atgattaatc cttaccttaa aagactatta aaagaaaaag 27840

gaaaggacaa taaaaaagtt attgagagta ttagggacaa tgatggttcc gtacaacacc 27900

taactttctt aagtgattat gaaaaagaag tatttaaaac atatggtgaa attaatcaat 27960

ataatatatt agaccaagct tctacaagac aaaaatatat tgaccaagga caatctataa 28020

acattatgat taaccctaaa catgttacag cagaggagtt aaatgaactt tatctctttg 28080

catggtctaa tggtattaag tcattgtatt atcaacatgg tacaaatgca tcacaacaat 28140

tcaatttatc taaaatttgt attaattgtg aagcctaaag aggtgactaa atgaataaaa 28200

aagaagcgtt tggattacta agtagaactg aagatatatt caaatcaaat gatattttct 28260

cacaagtaag taatgtacaa gaccctatta agatgtttaa tagggaagat gatactaaag 28320

cagatagtaa atcaagtaaa tttcagctag agtttattta taatacatat gtgtacattc 28380

ttatatatga aggtacatta aagctattta aagctgatgg tacggagcag ttaacacatg 28440

tagctgatat tgaaacattt aaagatatta ttgacacatt agaaaaggat gatacagaaa 28500

atggaaaaag tgagtagttt attagagtta aatacaacaa tcagacaaaa acaggatgtt 28560

attgtcatgg ttacacaaga tgagtgtgct aaatgtgaaa ttttaaaaag tgtgattcct 28620

cttttcgaag cagaaggaga tattactaaa cctgtttatg ttattaactt agatgataaa 28680

gatgtagata gagaaaaagc ggtcaagtta tttgacatta tgagtacacc tgtacttatt 28740

ggttataaag atggagaact tgctaagaag ttcgaagacc aagtaacacc taaaaactta 28800

atggaattag atttacttta atttgtaatt acctactact tatgctatac ttatattagt 28860

aaaaggtagt aggttttttc atgaaaggat gaatagttat cgcaaaaaat aaaacattaa 28920

ctatatataa tagtgataga tattttaata tacatgtaaa agataaagat gaattatcta 28980

aagctattaa agttacaact ttaaatgaag atgagataga aaaagatatg gacaacttag 29040

ctaataaatc aactaggtat atactaagag atgataaaca ttacatgcta tttaatgaga 29100

agtataacaa tgataagttg attgaaaaaa tatgcaagca cggtggacaa gtaacatact 29160

ataccgattc agtaattcct tactatgtgc ttaaagattt atcagctcac cctaaatcat 29220

cagttgtata tagaatgcgt agtaagttta gtaacaaaga gatggataat atagctttga 29280

gtttcatggg aacaaaagtc attattgata tttcagttgt atttccttac gtcaatcctt 29340

acgatattat tagaagttta tatgatgtta aaacgaatgt agacgaggtt catctatcat 29400

tccctcgtat tagttctata gacgctaaac aaggtaagta ctatacgtat gataaagaag 29460

cttataaact aaaacctagg tatacgcttg actttgcaga caaattaagg gtttctttgt 29520

ccgtgtggaa aatgtatatc tatattcttg ctagtaaaga aaataaagat tatgaaacaa 29580

tagaagacct acttactgaa ttaaaaagac aaagaaagat taagatttag gtgattttgt 29640

gagtacagca aatagaagag atatagcaag aaagatatct gagagtacag ggtattatat 29700

ccaagacgta gaagagatac tagaagcaga aacaaaagct atttctgaat tattacttga 29760

agattatgat aaggtaaaga atcataagta ctttcaaata gaagtagtag agcgtaaagg 29820

taaaaaagca tgggatggac taaataaaac atactttaca ttacctaata gaaaggcact 29880

aaagtttaaa cctttgtctg aattagataa agttatagat gtattaaaca aagaggatta 29940

agttcctctt ttttttattg actactatga ttagatatgc tatactgtat ttaagttaaa 30000

gaagggattg gtaataacat gaaagtttta attttatacg actatatcag agaggaacac 30060

ttttcagtta gtaatgatgg tagtgttaag aatgtactat taaatacacc taatggtaga 30120

gtactaaaac aactattgtc taatatttct ggtattaata gagataggag cacaaaggat 30180

tatgacattg attttttata tcctaaagta cctacaccta ttaagaataa ctatggtaaa 30240

acaattaagt accaagacgt taagttatct gaagttaaac cttactatga aagaatgagt 30300

caaataatca taaacaataa gtacgatatt attattcctt taggtaagct aggggttaaa 30360

tatttattaa atgtatcagc tatcggtaaa gttagaggtg tacctaataa agtaactatt 30420

actagtgaag ataaaaaaca tgatgtttgg gtattaccta cttatagcat agagtacaca 30480

aacgttaata agaatagtga gcgtcatgta gtagctgacc ttaagttatt aggtaagttt 30540

gtagaacaag gtgaagacgt atttaaacct aaagaagtta agtatgaact tgttacaagt 30600

attgagcgtg taagagaaat atttaataaa gaagtaaaga atgataatca tgacggtgta 30660

gacattaccg catgggattt agaaactaac tcacttagtc ctgatagaga aggaagtaaa 30720

cccttagtat tatcaatgag ttgggaaaat ggtcaaggtg ttacaatacc tttatataaa 30780

tcagacttta cttgggagaa tggacaacaa gatattgatg aaattctttc cttattaaaa 30840

gaatgggtag ctagcaaaga agacattaag gtactacata atgctactta tgatataaat 30900

ttccttatgg caacgcaagg tttcacaaac tttgaaaata atcaagacac taaggtaggt 30960

tggtatttag ctgtaacaca agaacaagca gagtctctaa gattatcaga ccttgcttac 31020

gaagtaacag atgtaggagg atatgacaaa cctcttgaag attttaaaga gtggtatgta 31080

ttgaagctac taagattctt atcagataaa ctaaaagaga ttaaaaaaga aaataaaaaa 31140

gttgctaaga aagaatataa cataaaatca aatgagtatg atacttggtt gaaaaataaa 31200

ctcgataaca ttgatataga actaacagat gaagataagt attatggtat cacagaagag 31260

caaaaaagat acttagagtt aaaactaaca cctgaggtta ttacaaagaa tatgcttatg 31320

gattctgaat ttaaagaagt agccgaatca tcacccgagt atatgagttt atctaacaaa 31380

gctaaagatt atgtattagg tacatctatt aatttaatta acacgtataa ggacaatact 31440

aaagttatta atgaggtaga tggaggtgac tttaattatg attggattcc attagagctt 31500

atgcatcctt atgccagtgg tgacaccgat gtctgtagaa gaatatactg tgatgttatt 31560

gaaaagttaa aagaacaaaa tagacctaaa gcattggact taatgtcaat aagttaccct 31620

agattaatta gaacattagc tagaatacaa tcaaatggtt tacattgtga cttagaatac 31680

atgcataaaa atgatgaatt ttatattaat gagatggaaa aaacccacca agaaattaga 31740

gagcattggg ctatccaaga atttgaagaa actaggtata atttatacca actagcccta 31800

gcagaacatg agaagaaacc atctgataga gacaaagaaa tacatgagta tagagctaaa 31860

tttaaagatg aaggttggaa gttcaaacca agctcaggag accataaagg tgaagtatta 31920

tatagcattt taggtataca gttaccttat agtaaagaga cagttaagga taaacctttc 31980

agtaatagta ctaaagaaga tgagttatca tggaaagact acaaaacaga tactaagtct 32040

ataaagatgg cattatcttt ggttgagaat gaagataata aaaagctact agacttactt 32100

atttattatg cctctttgca aactaaaaga aattctttta ctaagaaatt acctaaaaga 32160

gtaaataaga atacacataa tttacatggt aactataata gtacaggaac tgcatcaggt 32220

cgattaagta gttcaaacat taatatgcaa caattacctg ctcatacatc tgatataaat 32280

aagtttgatt atcaccaccc tattaaacgt tcttttatct ctagatttaa agatggtgta 32340

attttacaag ccgattacag tgccttagag atgcgtatta cggcactata tacagatgat 32400

aaagaaatgt tagagatgtt tttaacagga caagatattc ataaaaatac ggcaagtatt 32460

atgtatggta aaagtatgaa ggacgtaaca gcagaagaaa gacaagccag taaagctgta 32520

gcctttggtt taatttacgg ttaaaaaaat atagccgtag taaaactagg taaacctatt 32580

gagtataggg tgtatagttc acgttaggag ctacaggaaa tggtagttaa gaactatgct 32640

aacagggaag gctttaaaat gctaatcctg tgtagaataa tttaagtgta atttaataag 32700

taaggatgat ttaaatagaa tttaaaatag gagaaagata taatcacaat aagctatatt 32760

ctaaattagc tcatgtatgg tctcatatga tagacagatg ttataatcct aaatgtaagg 32820

aatataaata ttatggatta ctaggaataa cagtagacga tagatggcat aattttaata 32880

actttcttaa ggatgtagag ttaattgatg gttggagttt agagaagtat aaaaatggtg 32940

agttagtgtt agataaggat attaaagaac taggtaataa agtatatagc ttagataaat 33000

gtaaatgggc tactagagaa gagaacttag gatttgtacc ttcaagaagt aaaaagatat 33060

taggtataga ccctacaggt aaagaatata tattcttcaa tcagtctaaa tttgctaagg 33120

aacataactt aattcaaagc catatttctg cagttcttag aggggaaaga aaacatcata 33180

agaactgggt ttttaaaaca ctacaagaat ataattatca acctgtagaa aacccttcta 33240

aactttatgc acctcactat gttgcttata agaatcatgt ggaaattgat tatgatagag 33300

taaaaactaa gctactaaag agactaaata tacctacgtc aggcactaac tttagaaaaa 33360

tggaaaccgg tgaagattgt tatgggatta cattcaaaat agagaaaaga gaacgatttg 33420

attacactta aatacttaaa ttattttatc gaacgactat caaaaggtga gctttacgcc 33480

gagagggctt attgcaatat aaccgagtag agtacatgta gctcatacct acatggaata 33540

gcctagaagt agatagtaac gtatttactt aagatatagt ctagtcccct aataaatatc 33600

gggaaaccga gggtataaac ggagtcagag ttttcgtttg caggtaaaaa taatatgaca 33660

gttgatgaag ctactgaaat atttgataag ttttattcta ataaacctgc tattaagaag 33720

tctatagatg aaactcatga gtttgttcaa aaacatggat atgtagaaac aatgaatgga 33780

catagaagat atatacactc agcacaatct agagataaaa agattaaaaa tgagggtctt 33840

agacagtcct ttaacacgat tattcaaggt acaggtggtt accttactaa catggctatt 33900

acttatattg acgactttat tcaaaataag aatatgaaat cgaagttagt agctactgtt 33960

catgatagta ttgtagtaga ctcacctcct gaagaagtta atattatggc taaagttatt 34020

gtccatgtaa tggagaacct tccttatgat ttcttaaaaa taaaaattaa tggtgagtta 34080

agacagtatc ctatagatgc agatatagag ataggattaa catataatga tatggtagaa 34140

tacaacgaag agttaataaa gcaatttaat tcgtataaag gatatattaa gtataaatta 34200

gccttacaac aaatcaaaga ctactatgaa tcagataaac taactgagga gcaatacaaa 34260

caaaaaacgg aatatattaa aaataatatt gacagtttta aagttatata gtacagtaaa 34320

atagaggagg gtattatgga gatacattta gatacattag atttcaatga gttaacctta 34380

aaagataaca atggaaacac tcagactttt aatatccatg atgaactaaa acttagtgaa 34440

tatacaattc aagacgaaat gtaccaacag tcgtctaaat ttgcatggtg ggcttcatta 34500

aaagaacgtg tgagtaatta taccgaagca gagcaacgta agttagaaaa aataggagct 34560

caacttaatc tacaaattag agctcagtac gaacaacagg gaaagaaacc tacaaaagac 34620

caagtagagt ctgctgtatt tctttctgat gaatatcaac agcaagcaaa ggttgtagaa 34680

gcatggaatt atagagaaaa acaattacat tatatcgtaa aagcttttga aacacgtaca 34740

actatgttag tacagattag tgcggaacta agacaaacaa ataaaaatgg tggtattacg 34800

aatccattta cacattaagg ataggtatga taagtatggc aagtgaagtt aagaaatatt 34860

ttttagaatt agctgataaa aaaaagacta gtatatatgg aagagcacgg tctagacttt 34920

attgaatttt tacaaatgga agccgaaggt aaactttagt atgaactaac ttttagggtc 34980

actgtgcatg atacaaaaga acaaagattt gtatttatga aaggtaattt tttagatatg 35040

tttacattaa caagtaagtt attaactgat gatattttta gtacttatga aacaaatgag 35100

agtgcttata agttaatttc tgtatcgtta atagagaaag gtattcttgg aaaacaaata 35160

aaaaaatgtt taccgtctta tgaataattg ataaaagaaa aataaagtaa atgatacggt 35220

tgacagcaaa ggaaaaatat gttatactaa ttaagtaatt tttaaaataa aaggagaaaa 35280

gatattatgg attttaatca atttattaat cagcaatcag aaaagctaca atcaagtggt 35340

tttgacaatg aggtagaatt atacaagcca aaacaactcg ttttgcgctt aggtaaagta 35400

aaagatgcta acggtaacca aatcaataaa gagtctgcac ttgtacgtgt actaccgcct 35460

gtagaaggtt ctaatgagtt ctttaaggaa tttagaacat taggtattaa ctatgttaaa 35520

aaagatggag cacaaaagtt ctctatgctt actttacccg agaaagttaa ctcatctgtt 35580

gtagaccctt atgtaaatac atggttaaag caaggtgtac aatttagtaa cttccctaat 35640

aaacctgcac gacgagcata tattcatgtt attgaatact ttaatcaaaa tggtcaatta 35700

gttcctaaca cagatgaaca aggtaatgtt attattcaac ctatggagct atctaatacg 35760

ggtctgtctc aattgattga ccgactaaaa gatagaatgt tatcaccatc acctactgct 35820

acacacagct ttatttcagc cgatgatgca ttccctatta atattgctaa agctaaaaaa 35880

ggtgaaaaat catggaatgt aactgtttat cctacagtaa aattaggtgc cttacctcaa 35940

ggttgggaac agcagttatc ggatttagat aagttagcta caccaacaga agaaaataac 36000

cctaactttg taaactggtt gattaacaat gttaataaca cagaagtttc tcatgataat 36060

tttaaattca atagagaaac aaacacatta ggtgaagaat catcaacaca agagcaaaca 36120

caagctccta cgcaacaaag tgtagagcaa caattaccta gtaatttagg tggacaaaat 36180

aacacacaac caaactttaa taatgtacaa caaccaacac cacaagttcc cccacaacaa 36240

aatacacagt ttggtcaagg aacacctgtt caacaagcac cacatcaaca gacatcacat 36300

caacagacat cacagcaacc aacacaacaa gaacaaagta atccatttga gaactttgat 36360

gctaataaca ttgacgattc tcaaatccca ttcaacacaa atgaatcaac accagaacca 36420

cctaaacaaa atcaacctaa gagtgtagat gatgtattag caggtttaga tttataataa 36480

ctttatagag tgctatctta gcactctttt atttaaattt catataaaag gatgatataa 36540

tggctagagc aaaaaaaggt aaagaagtag atactacaaa tttaaatact attgacttag 36600

gtaaagaatt aggtttaact ttactatcag atagtaatag agcagatatt aagaatatca 36660

ttcctactat gattccacaa tatgatagaa ttttaggtgg aggtattcct ctaggaagac 36720

ttacagaagt ttacggatta actggtagtg gttaccttaa atagccacaa tggcttataa 36780

tgagttatta caaatccacg tgaattgctg ggaagcctta aagacttgtt aactacaacg 36840

taactggaaa cggtaagcgt gaatgttaaa aataacaagt atatgagtta tatggtataa 36900

cgagttatta aactgttata ttatatagtg taggtaatca gcatccaagc tcctgtaaaa 36960

tggagaaggt tcaacgacta tcgaaaaggt agctaatatt gagaagtatt agtgagtaac 37020

tgagtagagt agggaaaccg aagtacgtgg gaattgccta cgaaatctat ttaaaatgga 37080

gagtagtata atatggtaaa acgagtatgg tctaatgaag aaaaacaaga tatagtgaaa 37140

tcctttcaag aaggtaagaa atttagtgaa atacaaaaaa agtataatgc acattacttt 37200

acaattaaaa aagtactaga tgagtttaat attgacacaa atagcaagag aagatggact 37260

agtaaacaaa aacaagatat tttaagaatg tacactgagg agtctatgac tattgcagag 37320

ataaaagcag tctatacaac acatgcaaga gagataagta aaatattaag agactttggt 37380

attgatacat cttactatca acctaggaga gttaatagaa atattaataa agatttcttt 37440

gaagtaattg atactgaaga gaaagcatat attttaggtt tattgatggc tgacggttgt 37500

gttagatata gaagagaagg tcaatgttac ttaacactag agttaattga taaagaaata 37560

gtagaaagag ttcaaaaaga attgaattca gacagtaaaa tttatgaatc tcatagaaaa 37620

agagattata taaaaaatga aaattctacg tatactttta gtgttaccga tgaaaaacta 37680

tgtaatgatt tagctaaata tggtataata cctatgaaaa ctaaaaaaac agattggtta 37740

acacaagaca taccttatga tttaaggaaa cattacttaa gaggattgtt tgatggtgat 37800

ggttctattg gatgttataa taatagatgg tcaataactt tagttaacaa tcatcctgaa 37860

tttttaaaag aagtaggtag ttggattgaa gacttattag gttttaaatg tcctacaata 37920

tctaaaactt ctacctctta tagaataggt tatacaggta aaaaagctaa aaaattaatg 37980

aaaacattat atcgagataa taatattcat atagaccgaa aacaaaaact tgcagaccag 38040

gcaattaaag atatagtcta agcccactat taagttagtg ttaaagtact aggaaactag 38100

gggtagtaac tgaaatcgac ttttgcagta cacttatcta gagtagcaac acaattagga 38160

gttattacag tttggattga cattgaagga acagcggata atcaacgtat ggaacagtta 38220

ggtgtagacg tatctaaatt gttctcaata cagtcaggtg aaggtagact taaaaatgtt 38280

actgaactat cagtagaaac cgtaggtaaa gagttagaat actggattga tacatttaat 38340

gagaaagcac caggcgtacc tattttgttc atttgggatt ccctaggagc tacacgtaca 38400

caagatgaaa ttgatgcagg agtagaccat aaaaaacttg gaacgaaagc gacaagtaca 38460

caaaaagtag taaatgctat ttcacctaag cttaatgata caaatacagg attaattgtt 38520

attaaccaag cacgtgataa tttaaatatg agtaatcctt atgatgaccc tattaagtct 38580

acaggaggaa gagcttttga acatggtgct agtttacgta ttaaagtatc taaaggtaaa 38640

gaatcagaat taaaacagaa tgatgctatg acaggtaaac ctacgtataa aggtcatgtt 38700

atgcgtattg aaactaagaa gtctaagcta tctagacctg gtcaaaaagc ggaagttgat 38760

ttattatcag gttatgaagt aggttctgat ggagatacta ttcaattaaa cggtgttgac 38820

ccttatcata ctatctataa agaagccgtt gagcgtggtt taattactaa aggaacatgg 38880

cgtaattatg ttacgttaaa tggtgaagaa attaaaaaat atgataaaga ttgggtaccg 38940

acattaatgg acaaccatga attatactta gaattattta gtagagttta ccacgagaat 39000

ttccctcata agtatgcacc tttaaacaat acaaaagtag acactactca attagaagag 39060

tttaaagcat tacaagatta ctacgaagag cttagctcta ctaataaaga gactaaggaa 39120

gatgtaaatg aataatctaa tagatagaaa tattaatagt gttaaagaag cattaggtag 39180

ggctaataca aatgatgtat tgcccttacc ttatattgaa atagcagaac gttttaaaaa 39240

agctagagat aataaggagc ctatcattgt agaagagtcg ggctttcctt acactgattc 39300

tacagttatg tatattgagc atgtagagtc aagatgggca ggaggttact ctttagtacg 39360

ttataatggt tctgaagtca aagtacctaa aacaatacat tactcagata tctatgtatc 39420

aaatgatgta cacaggatta agattgtatt tgagggagca catccttatg aagaaagtta 39480

ataatgggaa tagatatatt atagacttag atggtattcc tactgacttt ggtagagact 39540

tagatatgct tttaaaaagg tataagaacc ttagatggtc attatttcat aggtactcta 39600

gaggtatgag tcatgacttt gagaaacaag agctacggga atacatagat gagcagttta 39660

ttaagttagt taaggagtat gatatacaaa gtaaagtaga ttttccaggg tatattaaaa 39720

ctaaactaac actacgagta cagaacagtt atgttaagaa gaacaataaa tataaacgta 39780

ctgaacttgt aggtaaaaca gattatacag tagagtcctt aacacaggag ttaaatgtgg 39840

gattagaaga aaatgaatta cttaattatg tctttgatga tacacaattt actgaagtac 39900

aaagtgaact gctaaaagag ctccttatta atacggataa agaagacaac gcatttattg 39960

tgtctactgt agctaatagg ttagaggtag aacgttcaga agtagctaga gagcttacag 40020

aacttaaaga ttatgttaaa tttaaaatta atgcttatca tgaacaaaat gccaaaaggt 40080

atatcaaaga taataaagta gataagcaaa atcatatgtg ggaataacct gaataagcct 40140

cccttttgtt atattattag tgaaaaaata ataacatagg gaggtttttt ctatgttata 40200

atgtaaaaaa taatgattgg agcttaatta ttatggctaa gaaaaatatt aatgaagtat 40260

taaaacaagc taccgctact gtagcagata agtatttaca agttcaagta gagcaagatg 40320

gttatacacg tacacaccgt ggtcagtata actacaaagt agtagataat aagggagaat 40380

tattcttata cccgattgaa acagatggta gaggaaatat taaaattatg aaaaaggctc 40440

ctgttgctta tacagatgga gaccaaattc attttgtagt taatactgtt aaagaccctt 40500

acaaccatgc ttttattaga actgaaaata ttaaaggtaa agataaaggt aaacaattaa 40560

ttcaagcgtt tttagcattc gttgaagacc gtttcagctt tggagtatac aacgtattcc 40620

ttgctaataa caagaaggat gtttttgctt tagttgatgc tgaaagtaaa gatgctaaaa 40680

aagtagtaga tagtaatgag aaacctcatg aagacgtgag cgctgagttt cctgctagtc 40740

cactacgtaa agacgttaaa ggagtagact caggagaagg tcaaggagat acttcagaac 40800

cttcagtacc taaaaatgta acagtaacag ctaaagaaac aacagctgat attacagctg 40860

aataattata taaaggatga cttagtttgg ataaattaaa tttatacaaa ggtgaccagc 40920

tattaaaaag tgaagagaaa caagcaggta aaacatcaat taaaattgat aacttaactg 40980

ctaacacaga ctacccacaa ggtacatata aagtatcttt ctctaatgaa tcaggagaat 41040

cagaaaaagt agatgttcct gcgtttaaga ctaaggacat taaagtagca tccgttactt 41100

tagatgtaga aacactagat ttaaaagtag gagaaacaca taatttagta gctacgattg 41160

aacctagtaa cgcaacaaaa gctacttata catttacttc agaacatgat gatgttgcta 41220

gtgtatcaag taaaggttta gtagaagcta aagcaaaagg tcaggctaca atcactgtta 41280

caactgatga tggtaatcat acagatactg taactgtagt tgttaaagat aaagtacctg 41340

aagctcctac agatgtaact gtagacccta aagaaacaac agctgatatt acagcataat 41400

cggaggtaaa aatcaatgga aaaaacacta aaagtatata aagatggtga agtagtaggt 41460

actaagactg ctgaacaaac aggtaaaaca actatctcta ttagtggttt aacagcagat 41520

actacgtatc ctaaaggcac ttataaagta gcatactcta atgagtctgg tgaatcagaa 41580

aaggtagatg tacctgaatt taagacatca ccacatagtg agctataata aattaaagtc 41640

caacttaatt gttgggcttt tttttattga cttatattta tttatatgct atagttaaac 41700

aagaattaat aaaggaggta ctatatggat attaaaacag tatatttaat ttcagataat 41760

gaccatttga aagttaaaaa attaatggaa aataaggaaa agtatattgc agttacgtat 41820

gataataaat cagtaagtaa ggtcaatgtc gttatggtta ttaatgttat taaagaccta 41880

gtgcatatgt ataggtataa aattgttgag tatgggttat ctaataatga taaggataag 41940

gaaatggtag ggtatttatt agaaaggatt gaggattgat gttatttatt ttaaatgaag 42000

tagcttcaca cacagaacat ttatccgaag gtatagatat gttcgacgtt gaaagtgtga 42060

tatcttttga ctcggcatta catttagcta gtgataatac gtatgattct gttatttttt 42120

taggttttat atacaataat gaggattact taaaatataa agaattatta aaaggtacaa 42180

aattatactt tgtttctaat ataaacttac ctgacaataa agagtttatt acagtaggtg 42240

atgatttaaa gtacctatcc ttattagagc aacttgtggt tctagatgac aaaggtttaa 42300

atattaattt cagtagttat acaaaagaca ttgctcacaa gtatactgag ttgtttagct 42360

ttaaatctac ttatgaggaa gcaaaagaaa tgggtctagt aggttaccct gcagatatag 42420

tattacctat tatgactgac aagttttaca acgtaaatga tttgtatgta ctatatgaag 42480

tagcgcctga gtataaattg cctttagctt atgaatgtct taaggataaa gaaaaaggta 42540

ttgttgttat aggttcacaa acaagaggta ctagtgatat ccttactttc tatgtaaaag 42600

gttatgatgt taatagtgtt gctaaaacat tcagagcatc ttataatgaa aattctaata 42660

tattcagtat atttattgat agtcatatcc atgtgttagg tgagaatatg aataagtatt 42720

taataacgga aggaagtatt tatgagtaat tataaaacag tagaagaagt acaagcaatt 42780

attgtaggta ttttatttaa agatgaaggt aaggtagtta catctaaatt taataagatt 42840

ctaacaagtt ttggtattga tagagtaaac cgtaatgagt taaaagatat tgtggacaat 42900

attagaaatg attcatactt aaatgacttg aaaaataaag ctgttaaagg tgaagtgtta 42960

ttagaagact taagagatgt agaagataaa caagtatttg aaggtaatga ttaccacgaa 43020

gaagtatcat cttatgtagt agcacatgaa aaagaattat caagactaag agaattacgt 43080

aagattaaca gacaaactgc ttatcctaca attttgtttg atgaattaaa acgcactatg 43140

gttaatgagc ttaaaggaga taagttatta gaccataaag taagtaggta tgcttctacc 43200

gaggaagaag aagagttggt tgtcttacta tcagattttc acgtaggatg ttccttccaa 43260

gatttaacta atgaatataa ctttgaagta ctaaaaagaa gattaaatca gctattacag 43320

gaaactatta aagatattag taaacgtggt attagtaatg ttacagtata ctttgtaggt 43380

gacttaatag aacatattaa catgagagat gttaaccaag cttttgatac tgagttcact 43440

atggctgagc aagtagcaaa aggaactaga ctattaattg atttcttaac cgaattatct 43500

ccatatgtat ggggtaactt acgttttggt atgatagcag gtaaccacga ccgcgtacaa 43560

ggtaataaga accaaaaagt atacaatgat agtgtagctt atattgtatt agattcttta 43620

ctgttgttaa aagaaaatgg tgtattagaa ggtattgaga ttatcgataa tagaaaagat 43680

gtatacacta ttaaagatac agtatgtaac ttaaatatta ttataaacca tggagatgga 43740

cttaaaggta aaggtaagca tatacctaag tttattgaga acacacatat tgacttatta 43800

attacaggtc atgtacatca cttttcagta acacaagaag attacaatag aatgcatatt 43860

gtagcaagta gtcctatggg atataacaac tatgctaaag aactacactt atctagaacg 43920

aagccttcac aacaactact atttttaaat aaaaaaaata aagacattga cattaaaact 43980

gtattcttag attaaggaga gataatatgg acattctatc aattatagcc ttaacattgc 44040

ttatcattat tattgttaat accacaatga actttgtagg tatgttacgt ggtgagcgtg 44100

atttagtaaa aaaaggaggt aaccctctac ccaattggca gtactataat gtgctattac 44160

ctaatttatg tggtattatc ctcttaggta ttgttgttta ttttggggat tcgatttata 44220

aaattacaac aaggatagaa gttctttttg ctattattgc gcttattgta atagatgtat 44280

tgttaacagc gttagtatta ttagtattga gtttcgtaac aaaaaataaa gaatagtaaa 44340

gaagggagtc cagtttatac ttgactcctt ttattatttg tggtatatta gatatgaggt 44400

gatttttgtt gcgattaaat tttggtaaat ttgataatga aattattaag acaaaagtaa 44460

gtgaaggtgt ttactctttt agaggtgttc cttattacta catagaacat gtccaagatg 44520

aaacttctga gtatgtatta gtatataaca tacatagtgt tgatgatgaa gtaccacaaa 44580

agaaatataa aatagaaaca gtaagtaaaa ctattagagg cggtactata ttaagtaata 44640

caattaagtc aatgctacct aataataaga agtataaaaa agtatatgaa cctcctatct 44700

ttttagctaa tattatacct ttaggtacag atacaactac aggtgctgta ggtaaagggt 44760

ttttcgaaag agaaaaagat agagtaacta ttacacaaaa agaaggaact aaagttatac 44820

atggtgagta tacaggagta tttatatgtt tatctaatgt taaatggatt aagtcttata 44880

cacctttaga tagtatatta caatattatc aacgtattaa aggggataga ataaatgtct 44940

gagataacta aattctatga gcaggatatt aaagatttaa ttagaacgaa gagacacatg 45000

tttaaagatg atgagataac aagtaatata caagatatta gaatatttaa tgaaaaagct 45060

atttgtcaag gtaaatgtag aactgactgt ttaattcttg atagaaatgg tactgttatg 45120

ggtatagaga taaagacaga acgagactct acacaaagac ttaataaaca gttatactat 45180

tatagtctag tatgtaagta tgtttatgtg atgtgtcatg ataagcatgt acctaaagta 45240

gagcaaatac taaaaagata taaacaccat catgtaggta ttatgagcta tattaacttc 45300

aagggtagtc ctgtagtagg taagtataaa gaagctacac catcaccact aagaagtcct 45360

tatcatacat taaatatttt atggaagcaa catttaatga ctatacttaa acagttaaga 45420

gattataata cttacctaac tggatataac tatagggagc acggtaaaaa taataataat 45480

gagggtagtt atacagaagg aacacaacgt atgagaatga aaaagtcagc tattattaac 45540

caagttattc attatttagg tgtagagaac tcttataaaa tatttactag aggtgttatc 45600

tatggttaca gtaatagatg gcagatatta gaagatgatt tctttaaagt tatacagaat 45660

ggagtgaggg tattatatga caaagaggaa acctgataca tttaaaccta agtataacgt 45720

atataaacat caacctgtta actttgctcc tacgggtaac ttatcaggta gaagtacttc 45780

tttttttaat aaaaaaagaa aagatatatc agatgaaagt attgttgtta aatacaaacc 45840

tttgtttgtt aaaaggtttg ataatgttac tgctacagac attaaaatac aaaagaagta 45900

tgcgttagac ttaattagtg aagctgtgaa tataaagaag aagtatcttg taatgaagca 45960

aaaaggtaaa ttaacacaaa ctattttaca tacggataga gtttattatg tttatagagg 46020

taagaaatta ataggtaaat gtagtattcg tgaacaacgt acatttagag gtacacattt 46080

aatctatatt tttagtacta gacatagaat atctgtacgc aaaaatagta gattaaataa 46140

gaaaagaaca ccaaagaaaa tgatatataa aggtggtaaa taatggttaa atacttaaga 46200

acaaaagcta aaaaaacaaa tgtaagtact ttatttaaga aactacaaag taaagatatt 46260

acactattag gagtgtccta tgatagtgat tatttcccta gtggtgtaac aatagtacct 46320

tatttagagg acatatcaca agtagaagat ggtatagaat ttacgaataa agtaatcgtt 46380

actgagaact taaaacctgc cattgtaggt atgaataata tgataagtga atcagggtta 46440

ggttacgtta aaacagaaca gttaaataaa aggttagaaa atactggatt aatgacagac 46500

ttattatcta aaggaacaga attaacttca acaaagaaag tagacattgt atcaactttt 46560

attgaaccta ctattatgta ccaagatact actattaata aagaattaaa acttagatta 46620

tacactatcg aagatgtatc tcctttaaat gattacacac atgttgtata cttactagta 46680

actgataagc aatatgacgg tcaatcattc ataggtacat tatgtaacca aggtacatta 46740

aacaaattag ataccctaaa agttcttaca ttattcaaag gtaataaatt aatcaataga 46800

agtgtgttct ctgttaagct agatacaaat aaatatcatt atagtttata taatacacat 46860

gagaccggta ttttcttttt agatgatgat aaagacttaa ttattgcttg tggtcaatcc 46920

tatgtaaaag ttagatataa agatattgtt agtagtaaag tagagaaagt tagtgataat 46980

aactataaaa tgattgttaa tcttgttggt aatgatgagc taacaattct cttatagtat 47040

aatactccct taaatatgta tactaaggta taaatatacg tatataaggg attttttata 47100

catatttttt tcaagtagtt agttaatttt taaaaggtat tattcttatt ttaaaattat 47160

atttataaaa cattaaaata ccttttaggt atagggtttt agaaaaaaga tttatattgc 47220

ttaaaatagt tacactatag tgtaaaaaat tagaatatcc tttatgaaaa taaaatagat 47280

gcagaaattg tgatatatta tatagtgtaa agtataaaac agttgatttg ataaggttat 47340

gtgaatacac atactcctta ttttagttca cacatatgta aagacacttg agacaagaag 47400

ggaatatata atggctagaa aaaagaattt aagaaataaa aaatctgata taaaggtagt 47460

tccagataag gaaagtattc tatctaaact atataataat aaactattaa ggtctaaagt 47520

ggataatgct atagatgaag atgttagtta tgatgatatt atagacctat gtaaagagta 47580

tgacttagag ttatccaaat ctgccattac aagatataag agtaaacgta aagaagctat 47640

tgaaaatgga tgggatttag gagaacttat tgataaaaga aagaaagtta gcgctactca 47700

aatacagaaa aaagaaaacc ctatgaaaga attagatagt gagaattata caccttttga 47760

actggctaca cagaatgtac aaacaatata tgatgatatt caaatactag atatgattat 47820

tcaaaaaggt gctaaaggtt taaactttgt agaaacatta gaccctgctt taatgattaa 47880

agctatggaa acaaaagata gaattacggg taaccaacta aaaggtatgt cattcatagg 47940

actaagagaa ctaatgatta aacaacaagc acaagatact gctatgacag aagttatgct 48000

tgagtttatt cctgaagata aacatgaaga agttcttcaa agaatggagc aattacaaga 48060

agagttctat aaaaacttag atttagatga agaaggaaga aagttaaaag atacattaga 48120

tagagtaggc tatacaatat agataatgag gtaatacata tgacagaaga aattagttta 48180

attccaataa aagatgttaa accacttaca gatatagtag atattataac acacctacat 48240

aaaggtgatg tacttagagt taaacaagag aaccaaggag atatattact tagactaagt 48300

actggaaaac ataagtttac tgaagtgtca agagacttag ataaagaaac catgttctat 48360

aaaaggtatt gggtactgta taatgtatct attaattctt tactaacttt tgatgtttat 48420

ttagaagacg attatgtaga atctacaaaa gttaagttcc ctaagaacac aattgtagaa 48480

tatgtaagag ataatcaaga atcagatgta gctaaggtta aagatatttt agtagatagt 48540

aaaggtaatt atttctatgc actttcagga gaaacatctt tatataatga agataaactt 48600

aataaaatta aaaattaatg attgacacac tcatatgggt gtgttattct tttattacaa 48660

acaataaaag gagcaattga ttatgattat tacattaaat gaagaagaga aagcattatt 48720

agaaaataaa agcaactata cgccattaag taagaataaa gagttcaata caccaaaaga 48780

agaatatatt gttacaagtt ataataaagg tgtacctgtg actgatattg ctaaggaagc 48840

taaagtaagt ataggtttga tttatacagt gttaaacttc tataaagtac ctaagaaacg 48900

taagaaatcc agagtagcaa aacgtgtaaa acatattact aatgataaga ataaagtaca 48960

agccttaatt aaagattatc aatatatgga tttacaaagt atctataaaa agtataacat 49020

tcataagaat ggtttatatt atattttaga tttgtataat attgaaagaa aatcagattt 49080

aaaagagaaa gccttagaag atactatcga ggtagaataa gaggtgtcat atgcgcaaag 49140

aacgaattgt agattacttg tataatgtaa agagcattga taataattta actatacaag 49200

gaatagaaaa tagtttattt aacaaagaat ctttacaaga cttagtacct gattttgata 49260

cttctagtag agagattaat gaaagtaatt tatacctatg tacaatacca gaagattata 49320

actccgacca cgtagaaagt ggtcagtata taggtataga tgttgggtat gtatctgaag 49380

accctgcttt tgaccattta ataggtcaag ttcctagaag tgtatatgag aaagcgcatg 49440

ttatgcaacc actaattaag atagaaaata ctgatataga ttatacccag gctgatatga 49500

ttaatgatat taaagtaggt acaagtatta gtgatgtaaa gattaaagat aaattaagtt 49560

taatgtcaaa taatcttatt acacatttag aaattgttga taagtattac tttgatagta 49620

gtatagaaga aacattatta aagtattatg agttaaagaa tcctgactat tatttaaaac 49680

attttcttaa actaaaagaa cttgtcggag acaatagaat gatatactgt cctctactgt 49740

taaaatgtat taaagttata gactaagtta ttatattata agtagtaaag gatggtgcgc 49800

tatgagtaaa aaagcaataa ttgcttatgt aattatctta gttatgttag ctttatctat 49860

atctacttat tacgtgtcct catatttata tcatgaaaaa accaaatcac aagttacaga 49920

ccaattaaca caccacggta aattaaaaaa agataaaaat gtagagtatg taggagacta 49980

cacgcttaag aaagtaatag acaacaaagc atactttatg gaaaaactac ctacctattt 50040

accaggaaga acaagtgata aaagtattga tatgagatat tataggacta gtaaatttag 50100

agaaggtgta aactttaaac ttattcgtgt gtatacggag gataatgaca ataatccagt 50160

acataagtat aggtttgaag cagtactaaa taaaaagtaa aggtatgata gtctatgaca 50220

gtagtaatta tactagtatg ttttgctatt atatactatt tatttaacaa ggattgagtc 50280

aaggttatgc ttgactcttt ttttatgcta tgttataatt taaatataag gagatgataa 50340

atgatgaaaa aaagtgattt agataatttg catattgtgg tcgtaagtat taagaatggt 50400

gttttacctg atgagcgtgt aattccaatt ggtttagatg tactaagtaa agtattagag 50460

ggtaaaacta catggacagt taagaaagaa attaaacata catttggtaa agatgaatta 50520

aaaagattta aagataatta caagttcttg caacataaaa ttgtagacct tgctacaaaa 50580

ggatataggt aggtgatata aatggatata gtagataaac tcatgttagg ttttatttta 50640

ttgttttatg taggtgtatt tatttggtac ttatgggaag tctggaaatt aacttcttta 50700

atatctgata tagttattaa gtattatgtt cgtaaggagt gggttaaagg tttattacct 50760

tatttgattc atcaagttat tattacgtta gtttgggcta ctctagtatc agtacctttt 50820

atacttagtt atataatgat aaaatatttg atagggggtt actaaatgga agtagtatat 50880

gagaatgaat gtagaggata ttatatttgt gtcatagata atgaaggtaa gtatgaagta 50940

tcatctttta aaaaatcagt aaacaaatat acccctgaaa ttatagggta tactacagaa 51000

aagttactct tggaattaaa aataccatgt acatatgtaa attctagtga agtagaaagt 51060

tttatgcaag aattaaaagt agcacgtatt gctcttgaca agtttactaa agatttatat 51120

aataaaggca taacaaatat tatattctaa agggtggtta gtatgtatac agaaaaatat 51180

agaaatttaa tccatattac acatagtatc ttggttagta ttcaagaatt agcaagtaat 51240

ttattaaata aagaagtaaa actagttaca aaagaaaata agtacttatg tgttgtagat 51300

ggtattacta tgttaattgt tgaggaagga ttagtataca cctattttga taaggtaggt 51360

ttaaaagtac ctgaacgtat tgcacttggt catttagcaa agagtttaca gtttacaata 51420

tcggaatcaa ataaagattt agaaaatcaa aaataagtgt tgacaccttt aacatgttgc 51480

tttatactaa gagtaacaaa acgttagagg tgatttttta tgtgtaaaga aaaagttcat 51540

agacagctat ctaatgctat agaaatatta gcaacttaca aagagtggtg gtcttttcca 51600

aaagaattaa gtcccacaga aacatttaag attattaact ggaaagaaga tacattagta 51660

tttgaagtta gagataacgg taattatata ggtaggttta gtgtagcaac tcctattatt 51720

gactttcatt atgatagaat taaaaaaacg acagcacaat acatgataaa ttattttgtt 51780

aaactagtat gtaaagatat gtatacgtat tataaattac agagaggaca gtaaaaatga 51840

aaaatttaaa taaacaaaaa cgcttgacgt tggaattgat tagtgataat ctaaatacac 51900

aacataactt aaatacatcg gttagtcttg tagattatag tataaaagac tttacaaata 51960

agaaagtata tgtaagaact aaaaaaggtt tagaacttac taatatgaaa agtttaaaaa 52020

gtactgagtc attagattta ttatttaagt atctagaatt aattttaaaa ggagatgtat 52080

aacatgctaa cgccagaaca aagaacacaa ttaaaagagt atcaaaataa aatgacaaaa 52140

aagaaaaaat aaatgttgac ttactaaata acaagttgta taattaactt aacaaagaaa 52200

aaggagattg ataaatatga aaaacttata taaaatttta ataggagtat tctttagcac 52260

tacactatta ttaggaggtt gtgcttacta ctcacaagaa gatacaccga cgcacaatta 52320

taaggaagac aagaaagaaa ataagaaaga tgattcatct aaagtagaag aacaagaaaa 52380

taaacaaatt aaagaagaca acactgttca aaataaccaa caagataacc aaacacaagg 52440

taaccaagca cagcagaacg aacaaatgca agaagcaagt agaagtgaac ataatggttt 52500

atctaatgct gaatatgcag acaagtataa tcaatatagg gaagctcaac gagcacaagc 52560

agaattagag aatagaactg aggaggataa agctagcggt ggtggaggcg gaggagcctc 52620

atggaactat gcaggagcta atgaaagttt tgaacaatgg ttacaacgtt cacaacaaga 52680

aagagccgag gcaggattac aataaaatta ataaaagata caggagaata agtatgaaaa 52740

caataacaca agaagaacta aataaaattc tagcagaaca taagctatgg ttagatagta 52800

atagtcaaga aggtaaaaga gcagatttaa gttttacaga cttaaatgga ttagaattaa 52860

taaatgctaa gttaatgagc gctaacttaa aaggtgctag cttaaaatat tcttctttag 52920

aagatgctaa tttaagaggt gctaacttaa aaggtgcgga cttaacaaga gctgatttat 52980

attatgctaa tttatattat gctaatttaa cagatgctaa cttacaaggt gtgaatttag 53040

caggagctga tttatattat gctaatttat attatgctaa tttaacagat gctagcttaa 53100

atgaggctaa tttagaatat gcagacttaa caaataccga tttaacagat gctaaattat 53160

cccaagcaag tactcaaaat atcaaaggac taaaagtata ctctatagat aatattggaa 53220

cttttaatgg taaagtgact tatattccta gcttagatag agtatacgca gggtgttgga 53280

taggtagttt agaagcgttt ttagaaaagg gattagagat gaatgaagga aataatagta 53340

aacttgagga aataagagat gcttactgct tttttagtaa acgtaaatag atataaggat 53400

gattaattat gaacattgta gaacaacgaa aacccataaa gaataagcat attaacctaa 53460

ctaaacatgc gtatgaacgt tatactttaa gagttagtaa cgatagtaaa gaacgtgctt 53520

gtcagtggtt tgctagtgct ttaatgcaag ctacttttga acatacacaa aaaggcggta 53580

atgaagtata tgtatttaaa aattatagaa ttgttattga taagcatcta actattatta 53640

cagttataga tactgaagat gataattggg aaggtataaa agaagcaaga gaacaaatag 53700

atacgtatat taaaggtaag ctaaaaagaa ctgttacacc tctatttact aaattagata 53760

gaatagatat tagtatccat gaagcacata tcagcatgat taaaacaaga aaccctaaga 53820

caaaagatat aattaacaaa aatattgttg aacttgaaag aaataaatct ttactattaa 53880

atagtataga aggtgtaaag aaaacagcac ataagtatta tgtagaatta aaagacattc 53940

ataaaagatt aaaggactga taataatgtg tttaaaagat ttaattgaag attatgtaaa 54000

tcaagataaa gaagtagtta taacagttac aagtactaaa gtaattattg aggcagacta 54060

tgatgttatt tgtttaccta aaagtaaaat tgatattgac gatttaaaag cttatgtata 54120

tggatttaat agatttaata tagagcaaat tgtattaaag gacgtggaat aatgcaagac 54180

ttaaaaagga taacacaacc tgaattagat ttattgatag aaaagcatga acaatggcta 54240

gctacaaatg aaaaggaagg agaaaagctt tttttacatt gtgtagattt aagaaatctt 54300

gactttcatt ccgctgacct tcaatattca actattgtaa tgtctagttt aagtgatgct 54360

aacctaagtt attgtgattt aagttattct gatttaagtt acaatgagtg tatatctacg 54420

agatttacac atgctagaat gaaggatatt gagttgcatc atactaactt agagtgggct 54480

aatttagtaa aagcaaactt agaaaatgcc tgcttagctg aagctaatat aagtgaagca 54540

gacgctagat gggctaatat gaaaaatgct aacttaagta tggctaattt aaaaagtgca 54600

gatttcggtg gtacaaacct aactaataca acattatatt atgctaatac tcttgacgta 54660

tttggaataa gtatatatac tataagtaat gtacttgatt ttgacgagca tgtaacttat 54720

ttacctgatt atgatagaat tattagtaat tataatgaat atacccttga agagtttggt 54780

aaactagaac ctacacttga gtacgaagaa gatagaataa aagaagtctt aaagaaaatt 54840

aaattagctt acgatttctt taaaggagtg aaagaaattg ataaaattta attcagacga 54900

acataaacat atacttaatg ttatggatag attaccatat acttgttggt tagatactgt 54960

agatggtgtg tcaggtgctg actttttatg tgtattaaat aggacacatt atgagcttac 55020

cgagctaggt ataatgattt atagttatgg tagttggtat atgataccat atgacaaaga 55080

agatttaatt gaatatgcaa taaaaagaga tatagaggag gaaggagaat ggtaggtatg 55140

gtggttacat ttttaattgt tttaggtatt atattgctaa gtgtactaat tattgttata 55200

ccagatttaa gaaaagcaaa aaaacgtaaa aaagacgcag atattaacta tagtcaatat 55260

actaaagaca tggcttctga gtactatgaa aagtatataa cacctactga acacattatt 55320

caaactaaag tagaagaggt aattgaaaac ataaagaaag agtatactgt ctctactgta 55380

attattgact cttctagtaa tgaagacaaa attatcttac atgttaacga taagtactta 55440

aaaaaggtag tgtataaaga tacgtatgaa tacatctacg attctaatac aaaataccaa 55500

tacattatta ataatgtaac atatgagtcg agtatcttat taaaacaaga tgaagtaaat 55560

aaattaaaag atatacttaa taaagtacct gtcacagcta agcatacatt taaaaatgag 55620

ttgcttaatc ataggaatga atatgtgtta ggttatatta caatatatat ttatgatgat 55680

ttaactgcta aaattacaaa gaatggttat gtacaagact ttagtacact agaagatttt 55740

tgtgataagt atgaagctta ctgtagattt gttagaattg atttatacga ctgggtaaaa 55800

gaagtaagaa ctattaatgg gtataaatta aaggtagata ttaaacctta ttttaaaatt 55860

actgctacta aaacaagtaa atacgaattt gtagtgagta atgatgtatc taatgttaag 55920

gtatatagag atggtatact actaactaac aggtatgtgc aaaaagcaat tgatatacag 55980

gaaatagtag aggaaacatt gaataataat actgtggtat tttaaaaaaa gggtatgaat 56040

aatgaaaaat ttaggtaaaa ttataaatat tattgaaaga gaatgggata ttaacataga 56100

tagagaatat ttggcagata tttattataa tgaagttgaa caaggtagaa ataaagcaat 56160

tagtacgcta aaacgtatac tagaaagaga taaagagtta tcaaagtact attatgacac 56220

ttttctagag gcattaaaaa agagagaatc tttagtgtta agttcacgag aagtagacac 56280

atatgattta gaggtagaat catatgaatc tcttttacaa atagagactg ataaaaatag 56340

tattaattca tttactgtta aactcttagc gtttgagtac aatgtacctt tagtagtatg 56400

taatcataaa tataaacaac atattataga cttttatggg ttggttgagg cagatgtttt 56460

tactttaagt gaagtaggta atattgtaag taatgtagtt ttagtagagg acattccaga 56520

agatttatta cctgaatcaa aagtatgtat tggaactatt gagtaaaggt ggaaggtagg 56580

gaaattccct acttttttta taaataagtg ttgacattgt tataagtgtg ggttatactt 56640

agtatacaaa gttaaaggag ataaacaaaa tgaataataa acaattagaa caattatata 56700

atgaagcaaa cagggtgttg aataaagata ttgatggtgt atcatatgta aatgcacata 56760

gaatgattaa agacttttta gatttaccta tcgaaaacaa agagaaaaga gagacattaa 56820

aagagttgta tcttattcta aataaatttt ataaggtggg agaataatga taattcaaaa 56880

gacatatact tgtaaagaat taatagaaaa atactttaat ggttatttaa aagaaggtac 56940

ttacacaggt acatccgatg gcttagatac ttattacctt ctgttagaaa ataaccgtat 57000

gactattgga tatcaagtac ctttggacgc tagttttata gtagaagaag aaattactaa 57060

tgacacaaaa ctagaaaact gctgggtatt attaaatagt catgcaaaag aactattcat 57120

ggataacaca ggtaatgtga gtattaatga ttgtatagaa atatacggag atgaattatt 57180

aactgtcagt atcttaatcg atggtacctt tattaatgta tggagagatg atgattattt 57240

taatagagga ggagaattat gaaaacaata acaaaggaag aattaaataa aattctagaa 57300

gaacataagt tatggataga aagcaatgag gaagaaggta aaagagcaga tttaagtttt 57360

actatcttac gtgacctaga tttaaagggt gttgatttaa gagaagctac cttaataggt 57420

gcgactttaa gttatacaga tttaacaggt gcggacttaa gatatgctga tttaagttgt 57480

gctaacttaa tagaagtgga tttaacagaa tccaccttag catatgcgga tttaaactat 57540

gctgatatat taagttctag cttaagatat gcttctttag aagaagctaa tttaacaggt 57600

gttgatttat tagatagtga tttaacaaat gctactttag taggagctga cttaaagcgt 57660

gccttcttat caaatattaa cttaacaaac gctgatttaa gatgtgctaa cttaatagaa 57720

gttaacttaa gctatgttat tttaacagat actaatttat ctcaagcatc tactcaaggt 57780

attagaggtt tagaaatgta ttctatagat aatattggta gttttaaaaa taaagtaacg 57840

tacctaccta aatataataa agtatttgta ggatgttggg aaggaaattt agaagaattt 57900

ctaaaaaaag gattagaaat gaatgaaaga gataataaag agcgtaccaa cattgtacta 57960

gcgtatcagt tctttaaaaa ccagctataa taatttaagt atgagtattt cttagtaagt 58020

aataagtagg ataaaatatc ctactttttt catatataag tgttgacatg aataagtgta 58080

aggtttataa taagtatata agttaaataa ttatagagga gacattaatc atgaaaaaaa 58140

tattaagttt agttttatcc gtattaattg tactaacaat aatcaatgtg ttgaaaaacc 58200

aagagcaagt agaacaaagt aaccaagaac ctaacaacca agagcaagta gaacaaagta 58260

accaagagtc tcaaaataat gatgcagatg accatacttc atacgtacct gagaataacg 58320

aagagcataa agacgttagt gaagaacgta aaagattatg gggtacagag tatcaagaag 58380

gtgaaacaca taacccaaat gctaaagtgt ttaatcaaga tacaggagaa caggttcaat 58440

aaagagtaag aggagcactt attatggagt attggaaaga acaagacata tattattcaa 58500

aaacaaaaca aggtgttata agctatatag acttatcttc cttacctaaa aagaagtctc 58560

gtattgattg ggtaaatgta aaccattatg taccctttga gtatcatagc acgaaaggta 58620

agctctatat taaatacctt acaccaacta aaaaagaatc tagagtagaa ataacttaca 58680

acaataaaac acaagctacc caagtagcta atgtctataa ggttaaattc aactttatta 58740

cccaaggtca gaagtcttat actgttcata atataaaaca aggagatatt attaaaaatt 58800

gcgaagtact aaaagtagta gacactcatt taggtacaca actttatgta tataacataa 58860

aggaagaagt ctatggtaaa gtaagtaaac aaaatttact aaaatataaa actgataact 58920

atataccata tggtactatt cctcaatcta agatgttata ccataagaaa catattcata 58980

agtatgttaa atataaagac ttatttaaat ataagtatac aactaagaaa aagatagaaa 59040

cgatttgccc taattgtaaa agaaaaaaag atattagaat tacagattta attaaagata 59100

actatagctg tcaatgctct aaacaatact ctagcttcgg agaaagatta acacaaagtt 59160

atttagatat tgcaaacata gagtatatta gagaatataa atttaaagaa ttaggtaaaa 59220

aaatatttga tttttactta cctaagtata ataccgttat agaagtacac ggtgttcaac 59280

attaccaaga agtcagtgga tacatgaacc accagaaaac aaaattatca gacatagaaa 59340

agagagaata ttgtaaagaa aatagtatac aatatataga gattgatgta ggtagaagtt 59400

atataagtaa gtaataggta aaagaaaaca atatatatat atatatatat aagtagataa 59460

agaaatcaga taagtaacac gtaaagaaac aactgatatt ataagtacct atataccaag 59520

gaaataagta atagataaaa aaacaataat tgatagcata tagataagca gtaggtagtg 59580

tataagcagt aggtagtgta taagcagtag gtagtgtata agtaatagct aaatagataa 59640

gtaaataaat actgtataac agtttgaaga tatgaataag aagaaagaat tattaagtat 59700

taataaatat tctaatagta agtagtaagt agctaaaaga aaatagctaa aagaaagtag 59760

ctaccactat cacttaggta aaaacagtta cctagtaatt tctttacatc ttctagtaca 59820

tggtatacct atatatacta agtagtaagt agtaagtagt aagtagtaag tagtaagtag 59880

taagtagtaa gtagtaagta gtaagtagta agtagtaagt aagaacagtt acctaggaat 59940

ttcttggctt cccatcttca tagtgtatat atagttaggt atctaactat tagacatcta 60000

actatttatt tttatatagt tttaactact gtgaactatg cttatgtagt attaaactat 60060

gctgattata tactaaacta ttctaatgta tagttaaact aagctgaagt agtatttact 60120

gtgtataaag gtatatttag tattagatat tgtgtatatg gtatactata attctgaaca 60180

ttacttattt aatatttata tatagtttgt ttctgtggta gtattgactt aattttccct 60240

agagtaaaag tttaatatat ttagtaattt ccgaacaata aagaaatttt aactatttta 60300

cacatatgtg ttggcagtat attacttatg gtttatacta gtatataaag attaaaggag 60360

atgatttatt atgaagatta aaagagaagt ttcgtttata gaattaatgt atatgtatta 60420

taaaggtgat ataaaaaaag gtcgacacta ttctactgat agtcagttta ttgttgttat 60480

aactgttgat gatatatcgt tttataatgc attgtatcct aataaatcta ttactattac 60540

tatacctaat gacactaagt ttattgtaga agcggttata gatgcttcta ctgagttaag 60600

tagtatagta gttacttata agcaaggtaa cagtgtatta aactcagtat ggtatagaag 60660

tagtattaat gaagttattg actactatgt cgaaggtaaa aatacatggt tattgtctgt 60720

tagtactgtt gtagataatg agttagttac tatatggaaa gatggtaacg tattgtgatt 60780

tggtatatag taatattcag tatacttata tatgtacagc acttgtatta ttatgtgtag 60840

tactagtata tagaggggtt aaataaccgc ttcaataaag acttagtaac gaggagttgt 60900

attatgagtt tatcagatat ttatgtacat ttaaatcagt taggatataa aatagaagtt 60960

ttaggggaca tgagtacatt aaaagttaat gactactaca tcgaaaatag atgtatagat 61020

agtggtttta gggttacagg ggataatgta tttttatctg tatattatgg tgaagacgta 61080

gtaagattct ttaaacaaag gttattaaag tagtattttg ttaagttata cttgagaata 61140

attataaagg aggaagtaag ttgagtaaag cattggagtt tattttacgt tatatatttt 61200

gtttagcagg agtaatttta ggtatgtggg tagggaattt aatcataggg gaagaggtaa 61260

ttcctattac atgtttaatt ccttttgtac ttgcttttat actctctgta ttacatcata 61320

tgtctgatag gaaggagaga taaatatgat aggactaaca atgttactta caatagtagc 61380

tgtaatggtt ttgtttatgt atacctttat tctagtagaa atggttcagt caattaagta 61440

tgataggttt gataagtgga ctaatatcgt atcatttaca gttatgacgg ttgtactggt 61500

atcaagtata ttagctttat ttggtattta ggaagcggtt tttgtaaggt aagtaatgga 61560

aataaaaacc acttcaataa aaaaggggat tagtttatga gtatatttat aagtatcgtt 61620

gctatatttt tagctattat tggtattgta ctaagtataa ggtttggtaa gaagtattat 61680

aagcatgtac ttgataatta tgatagtgtt agtgatttag aatcagcttg tgtgtttggt 61740

ttattattta tgagtatttg tattggtact atttctattg ttttgagttt aggttacata 61800

gtaagtagag tactttatta tataggagag ttgtagatga tgagttcaat tttaatgtat 61860

attgcggtta gtattttagg tattagtatt atagttggta tgcttagtgc tttaattact 61920

gatatagtta aatctattaa gcagaaagaa gtgtttttta gtatatatct tattgtttct 61980

tttgttttaa ctgttttagt ttttgcttct ataatactac atatgttagg tatgtaatag 62040

aaagagggta ttagtatagg ttactttgta gtaagtttat cattaatgta tttagttata 62100

gatatagata tatgttatag agtatatagt aaagaaggta atagtaatag atttaagtta 62160

gcagtgtttt taactatact tatattgatt atgtttatat atggagtagg tgttttatta 62220

acacaataga aaggggctta ttatggaaga attagatata ctagatagag tgttacataa 62280

taaatcaggt ataggtgagt ttaagtatac aaattgtata agaacaagtg atgataagta 62340

tatttatagg ttctttctgg aagataatta ttttggttgt gctattatgg tatatgatga 62400

tatgagtgag tatgaagtag tagtacaagg tacaggtaag gtgtatgttt ccttattgaa 62460

agatgtagtt agtaatatgt ataagatact agtagatgag tatgataagt atttaaaaga 62520

tagtgcatat caaaaatata tgtataatat atttgaagaa caagtagaac agtataacta 62580

aagtttttct ctagggaatt gatagtgtat tagaacaatt aagtaaagat aataaaaatt 62640

tatatttttc tgaacaagat atagatatta gtaaacttac tgatgacgag tattatacag 62700

ttactaaaaa ataaaaggag aatagataat gagtagtaat aaaaaaatag cagaaagagt 62760

tattgagaaa tttttagatg agactaataa aggtgtagat tttactaatc aagatgaatt 62820

taaccgcttc ttagataata cagaagactt gtatgaagta tctggtactc aaagagataa 62880

gattattaag tgtttacaaa acattgtagt tactgtattt atggataagg agaaataaca 62940

atgaaaacaa taaaaagaaa aatagtacaa gaaggtatga acaaagaaga aactatgatg 63000

gaagacgatt ctgttgtaat caaaaaaatt caaaaaataa caggcggagc tattcttcct 63060

ttagccaatg gcaaggaata tgtagtagtg tttagtaaag tagaccctac taaattaatt 63120

gtatttaatg tggaaagtaa tcaaatctat ttaagtggct ctggtttcga tagtgaactg 63180

tcttatgtag acagtaaaag caaccctatt accttagaaa cagttaggtt aatcactaat 63240

ttattataaa ggttattagg ctcttaaaga ttaagttatt ttataggata aatactacta 63300

gaaaattatt atcgtttaat atagaactat aacgtcccta gcttaagggt cttaaatata 63360

aaggaaggta ttagaatgac taaggttgta agtagagggt atagttttga agaacaagaa 63420

gtaagtatga actataatca aggacaatgg gtgatttatg caagtagaaa accttatatt 63480

actgatatta tgaaaaagta ccccgataag gtggaagtat tagaacaatt agagaatgaa 63540

acaccagtat tggttaaagt tgtattggat gaagatttaa ttacattgag aaaaccagta 63600

agtaacgagc gtaaagaaca aatgaaaaag attgctaaag aaagatttgg taaataatta 63660

aataaattaa aggaagtata aaatatggct tatcaaagaa aatttttacc tttttgggaa 63720

ttgtgtttaa atgcaaataa agaaaagtat ggagaaacaa aagaatttga tggtgtactt 63780

aaagtcacac taaaatatac tagtgaagaa gaatctgaca ttaataaaca ccaacgtgat 63840

accgtaacac tggtaggaac tagactaatg ttacaagata tctagtatgg ttatggtctt 63900

attgagaatg agtatgcttt aactaaacta gttaaagaag ataaacagta tttacaatat 63960

catatcgaag aagtagaagc ggtattaaac cgcttctttt ttatacatta tttacattct 64020

gagtaaatat actgtattta atcttggcta ataattgtat atcaatttga gcatagtatg 64080

cccgtttcaa catagttaat ctaataattt atatatttat ctgttagtta tgtataaata 64140

tttgttatta cttatttata tatttgtatt tcgtactaac cgtacgactt atcttttaaa 64200

agataagaac aaaacagagt ataccttgtt gttttacgct acgctacaac aaggtaactc 64260

ctgtaataag ttattcgtat taaaatacta acaactaatt acttgttgtt tatattataa 64320

catatgttta tgagaattag atgagaattt agttacaaca gcattataat aatattacag 64380

ttatgttaca agttgctaag tatgttttgt tactacaata tattgaatat gaaagcttta 64440

gaccttttct gcagacaagt aattattaca ggtatgtatg ataaaaggta agtatcaggg 64500

attaaattaa ggttggatta atgaagcgga taagttagat actgattaaa ataaaatact 64560

ttacattacc taaaacttat gatacactta ggataggata aaggaggaat atcaatgaat 64620

attcaagaag caaaggataa attatacgat gaattacttt atacagtaag tctttgtgag 64680

ggaacagaag aagatttact agaacttatt gagaatttat tttatattta caatgacgag 64740

cctgcatttt taagtaaaga cggtatgcaa tatactatta aagattttat ggagagaaga 64800

aaaacattag aacctatctt aactgaatta ggtatagggt acgcaatgat agaatatcac 64860

acacatacag aatacgagtt agttacttat tcagtactta aagttataca gtatgatgta 64920

gataactata ctgtaattat tgatactaat agtgataaga atattaagtt atcagattta 64980

acattagaag ctgttaagga tattttgaat caaattaagt agctagggtt gtttttaccc 65040

tagctttttt atatgcttgt attgactatt taactacatt atataagcaa gtaagtattc 65100

taggataaat actacctaaa aagtattacc gttgaatata gacctataag attaaggctc 65160

tcttactgtt ataaacatca taagtataaa tctatgattt tcctaagtag caggcgctgt 65220

tttcccttta tattaaccgc ttcaaacaac ataaaaaaag attaggttaa tagcctaatc 65280

tataactctt ttatataatt cttgtaattc tttttctaac ttttttattg tttctatatc 65340

attatttctt ttaatagact gacatataaa tgcaatacct ttaatcaaat taaatggtta 65400

tttttacact gcattgtata caattaaatc gattgattat aataattaat ttaagctgta 65460

ctttctagtt tcttctatat aatagtaata aatcatttct ttaaaaaact ttcgtataac 65520

ctattgacat taaatacaag atactgtaat ataataagcg tagtaaacaa accgaaagga 65580

attgataaga tatgaacgta aatcaaattg gagatatact aatggaatta ttagatatag 65640

atggttacaa aagcagtaac tactatagaa atgatttaaa atactcaaca cattatcaag 65700

ttaaatattt agcttacatt gatggtagtt atgaaacatt agaactattt aaagaaacga 65760

aagtctttag cgtatcacat tcaaatagat taccaataac attaatgtta aggtagtgaa 65820

caaacactta tttgtagaga taaacaatac gttataccta gtgaatgaga atgcagaaat 65880

tattaaagaa aaaaagttaa aataatagtt gacactatca ttaagatagt gtaatataat 65940

agatgtagta aacaaaaaca aacataaaag gattgataca catgaatatt aaaatagaaa 66000

ctaaaccaaa aacaacaata acagaaatta aaaaagatgt taaatacatc aaagacagca 66060

taggaaaaga attaggatta aaaagagaac aattcaaatt gcctactgga ttaataacac 66120

taagaggttt tagtaaggca acaaactcat ggataaacct aacaaatgtt ataggggatt 66180

tcaatgaata catcaaaaaa gaagattact tggaatataa actatattgc aatgtacaaa 66240

caaaataaaa ggggattatt aacatgatta agtttaaata caaaggtaag aaataccttt 66300

caacacaaaa gacggatgct attgtaacta ttctaggtgg tacagcagta atcacattga 66360

tagactggtt tattagatta caagagaata ttaatatatt tattagataa gggctaacca 66420

cccttatttt tttatgccta tataaccgct tcacattagt gtaaaacttc ccttatttct 66480

ttgatataat actttacaaa tacgagctta tactgtaata tattaattgt agtaaggaac 66540

acaacaaaca aaaaaagaag aggaattgat tacttatgaa aaactataaa actttagaag 66600

aattaaacca agattataca gttattagaa cacaaaacga agcttcaagc aaacgtaata 66660

acttagatgt tactgatatt tatgttaatg attggagttt gttacaatat ggtatttact 66720

ttaacaaatt cgataacgtg tacaatgtag tttcaatgac atcaggaaac aagaaatata 66780

atattactgc ttatgaactt gatagcttta ttatggatga gttaaacaaa cagttagagt 66840

tatttattaa tgcaggaaga ctataaagga acacaacaaa gaacagcaaa caaataaaaa 66900

aaacttaaaa aagttttaaa aaagtgttga cactaacatc aacatagtgt aatataatag 66960

atgtagtaaa caaaaacaaa cagaaaagga attgattaat tatgaaaaac acagtaaaag 67020

aaatggcaaa cggaaacact aaacttgaaa gattattagt tttagcaatt gaggaagcgg 67080

ttatgacaga gcttgttgaa tatgatgcat tagataaata caaccactta gaacaacagt 67140

tattaaacaa tgaagcatta acacaagcag aacgtaaacc agctaacatt gattacagca 67200

cttacgaggg ggctatatta gcacaagaca aagcagaaca ctttactaac gttatcttaa 67260

accacatgaa caaagaacaa tttgaacaaa tgattatgga tattgaaaca ctagaattta 67320

atgcagaaca aatgctattc taaggagaca ttacacatga acttatctga gaaagaactt 67380

atagatataa tagacaacgt taatagcttc actggtattg atgaagctat taacgaaatg 67440

gaaaacaaac aaacaactaa aggcagtgac aaagacagcg gaacgattaa acagtacaat 67500

agtttagatg agttaagaca agactatgac ataacaacat tagcaccaga tgtaataaaa 67560

gaattactga ataatcatta gtgtaaaact tcccaaaata attaactaaa actattgcaa 67620

ttaactgtat atttgatata atgtaattaa ggaaaaacaa ataaaagaaa aaggattgat 67680

aaactatgaa attacttaac caaatgaaac aaacagcaga acttgaagga attgaatttg 67740

atttattatt aacagctatc tatgaaacaa tagaggtaga agctgttgaa catgatttac 67800

tatgtaaata cattcatatt gtaaaccaat taaaagagaa taaagatata acaccattag 67860

aatatatacc gtctaaccta gactttacag acgatacaac aataagacta gttgataata 67920

aagtgtttga gttagcagat tatataattg aacatatgag tgttaaagag tttagtaaac 67980

acattaaaga ctatgaacaa attaaagcag aagctataga aatgatgtaa aacaaattga 68040

aagggaataa actccctttc ttttttttat tatttattag gattgtatac aataggttaa 68100

tataaatata ttatacgggg gcaggggtaa aatgccacta aagtgggtgg gtctgacagg 68160

gctatggggc tacctaagga acctaattag tgagtaatat tatataactt attattaaaa 68220

gtcaacatta ctcattactt tattaaacta tgtcaatatt actaataact aattgtattc 68280

attttacaat aaagttagta atatatcctc ctcttccctt acacttaatt agagtattag 68340

tatattacag catataagta gtttagtata taggagcctt tatatatata tatatatatg 68400

aggttgctat agtggtcttt agtatactat tttaataact agttatacta tgtactatta 68460

gtagtgagta atattatata acttattatt aaaagtcaac attataaagt atataataat 68520

aaaaagtcaa catagtttta ttattgttat taaagtaaac atggtaagat ttcttttact 68580

gttattattg tcctgtctat ctctactgcc tttactatta tagtagtagt gttactctat 68640

ttcttacaat ataaaaaaca cctaaattaa taggtgttta atgtgacata tcatatctat 68700

attcaaataa ttctctatct acttgttcga aacctttctt tttatctttt ataatatagt 68760

taccgtgtaa aactttttca atacctgaag gtgcattaat aaacaggcta ttgtttcctt 68820

gtttgtctac tgctctaaat gtctgacctt ctgtccactg attgatgtca ttcttattat 68880

agcctgtata ttgaatatat tctactacgt cttccatgtc gattaagact tttagcatat 68940

actctcttac tttagcataa tcatctgtaa gggtatctaa gtctaaaggt tttacttttg 69000

ctatattgct tatactacgt tcttttacag gtgtttttgc atattctatc attaaatcaa 69060

ataactcact atctgcgcct aagcttcgaa aagaatatgg ttcattgaga aatacccaag 69120

caataggttg ttggttttct tttttaataa gtattttttc ttttctcttg gtagtatttt 69180

tatttgcgag gctggtttca tatcctaact gatttacctt cttaataaat tcatttgtat 69240

acatttttta atacctcctt atttattgtc cacgatttct atttcatgta ttgtaatcat 69300

gtcatctcta aaatcatcta tatgcttaag gtaaacaata ccatcatgat ttctagacat 69360

gccttgtaat tctttgtatc cttcagattt aatgtcttta ataagctgtt ctttactagt 69420

atatatttta tcttctctat aagagtagct gtcttcgtat agctcacaat tatcatgctc 69480

tacttggtaa tatttcattc ttttttactc cttttttcat agatatttcc tacaacttca 69540

gtattatcaa tctctgaaat gcacatcata gagaatggta tgtaatctcc cccttcaacc 69600

catccaaaag aagcttcttt aaatattaca ggtctacatt ccccccaata tctaagtata 69660

tcaccttcaa atatttcagt accattctta tcttcaagtc ctgtagattg cataattaca 69720

aggttttctc ctaagtaacc atcacaagca aataggtgtg aatatactgt atggtctgca 69780

aagtcaaatc tagcaatatt aaacattctt tgtgattctt tatcccatgc tctaaattta 69840

atcatctgct ttatcatcct ttctgttttt taatgactgt tttaatgttt ggtaactttc 69900

tatattttgt aattgttggt agagtgtact tgcaatttcg tcgaaggctt ttgctttttt 69960

gtatacttcc tctaattatg cttctgctaa ttttctatct cttttaattt tttctgcttt 70020

ggctactagt atatggtctt tattcatttc ctctataata aagttcttat agttttccat 70080

tattattcat ccctatttaa attatcatct tttaattctg gtaatatatt ttttaaaaca 70140

tatcgctcta tgtcacctat agttttagtt ctataagtac ggatatttct gttgtgaagg 70200

tatacactta agtcttccag tttagactcg atgtaataaa aaggatagct tatacaactc 70260

attgatatgg atataaaatc taatacattt tctggaattt ctctaataaa ttttttaata 70320

ttgtttattc ttctttctct ttttgctttg ttataaagtt tctttaactc atgtttgtgt 70380

tgtttaatta cacgtagttg agcatcatta agtaaactac tatcatcttt gtagatgtag 70440

tctaatatcc ctttatataa ctttagtaac tctatctcgt ccatataata ctcccttcta 70500

tttttatggt tgtaaccaag tccatttttc aaaccataag aacttcgtga tttgatacct 70560

atagcctatc ttataatcaa aagggttaaa ttcagatgtt tttatagtta ttctttttct 70620

ttttttagga ttgttaatgt taactagaat aatgtctaca tattcagtaa attcatagtt 70680

atataaacca gttccatcaa ccagttcaaa gttactataa tgtacgtggt tagatatttt 70740

atatatcgtc actaactctc ttccccttct ttacaacttc ttcccataaa tctatttttt 70800

taaagaaatc tgagtctatt ttgcctttta gtctttggtc tgtatattca ttataaaagt 70860

tgaacgtgcc atctttataa aaagaataat atgtgtcgtc ggtgtgacca gcatcaatat 70920

actctatatg gtcttttgtt acttctggtt tatcataacg tagtactggt actttattac 70980

gtagcagatt tatttcttct ttactcaatc ctgtatatcc ttttaactta aagccaaacc 71040

tcaaccaaaa atctatttta ttaaggttaa aaggttcatt tacttttata tctaaaatac 71100

tatgcataaa cagcatataa acaatttcta tatactctat acatgttgtt aaaaaatgtt 71160

gtttgtcttc aaaatgattg taaactaata catataaaaa tgtaaaagga aaaagaaaaa 71220

tagacattaa aagatataaa aatgattgca atctagtatt cattacttaa ccacctctac 71280

atcatataat actggatata gattaagtat gtgtattcta taaccgattg ttttaacttc 71340

taccttatcg cctactttta acctagcttg tatatctgcg ctatcaaatt tctttttgaa 71400

taataagtcg gaattttcaa taactttttt attatctact acaatataaa acttatctgc 71460

gtcgtcttgt cgtttgttat acttatctgt aattgttccc tgatgtactt ctttgtgttg 71520

gtaactaact attgtataga taggtaatgt gataacaagt agcaatgtga ttataccgaa 71580

taatgacagt attccaacaa taaagatatt gaaccaatcc atacttttaa gtttttgaat 71640

cattacaaca atcctccatc tttccaaatt aaagttaaag tcaggtcatc atttaagatg 71700

taaaaagata caataggaaa acattttttt gaatccatgc gttcttttat gctaatgtac 71760

gtatgaattg tggaattata acatcctgta tcctctttaa atacctcaag caacctatca 71820

aacctagtat tttcggttaa ttcttcttca gcttcgactt caaaagtgtc gtcagctgat 71880

ataaattcac taacaagaca ttttcttccg tcttccgaag aaaaataaac aaagttctca 71940

ttatcttgat tttctgtgta aattctcttt ccttttgtta aatcaggata ttcccaagcc 72000

cattccatga gttcggctag cgtcattact tttttagttt ttattttcat ttctatatct 72060

cctaattatt taatttttct atcattttca caatctcttt tgattttcta atatcagcat 72120

tttcacagtt ttttaatatg aagttaattt tgttttttac atcattaacg atactgtcta 72180

cttctttttc tgttggctta gtagggaaaa gcaaccctac aactacctga atttgatttt 72240

tatttagtga gtaaacacta atgttacatt tctcattaaa gtcaatatgt ggtttacttg 72300

aattaaatac ctcatctaca attgtattta attcttgtat aggtttaaaa taatgttgtt 72360

ttctttgtat tattacctgt gacattagtt tatatagttt ctgttcttta tcaagaactt 72420

cttttgtaag ccttttaact tctcctatcc ttatagtatt accccatgca tcataattat 72480

ttttaacata ctcagcttct tctatgttag tagtatatcc tattactttt gaggtgggtt 72540

cctcatcata ataacagtcc tcttctacat atatagcata tatcttattc atatctatca 72600

aacctttctt taagttaaat taactataac atataaacat taggatgtca actactaata 72660

tacacttttt acagtaaaca aaaaaaaaga acctttttac aggttcttta ctaggttatt 72720

aattttttaa atcttgattt ccttttatta gcttcttatc atcaatagga tgaccattgt 72780

ataaatattt tacttccata tatacatgat tatccgtagc cgtaagggca tctaggatat 72840

ccggatttgt gttaattgca tttgtatcag gaaacgaaaa ttttctttta tccgactgga 72900

ttgtatctac atgaaatttt tcttgttttg gtaaagagta attaaggtct tctaaatttt 72960

gtaggaattt agtaagagaa aagggtttga actttccttg taaattatta tctatataat 73020

catttaatag tcttgtcatt tcctctttat ttaaagtcat tgtttcataa tcgttaacat 73080

cataaaaaac aacaatatta ggttgctcaa tacttgtgtc tccatctttg tacttagcaa 73140

tgtaatagcc tatttcacct ttgtgagcta aataatcttc tttcatgata ttaaatactt 73200

ctctagcaat aggttttgta tatagttctt cccattcatt tgtttctgtg ttgtaaaaat 73260

gtggtaataa gtttgccatt ctgagttatc ctttcttatt ccgatttaag ccatattttg 73320

ttagtgtctt taggtggttc attgctgatt gtgtacccgt cggtacccat atctaatgtg 73380

tttacaatga caggctgagc tacagcttct ttttcactct ctaatgtttt gaaactaggc 73440

acatctgttt tattagattc ttgtccatcg actaaccaag agactttaaa gtcaccttta 73500

ttataagtag tattaggttt taaatctgtt aatgttactt ttacagaact acctgtaact 73560

tcatcagaag ttaaaataag ctgttcctct ttgttgtaga cctttaattt tttagacata 73620

atgttatccc tttctgttgt gtaatacact aataatatag catataaaaa acaggtaagg 73680

tctttcaaaa cctttacctg cttattcttt actgataatc ataccaatca agaaaatcat 73740

ctgaacagct taactctata gttatatcat ttataagttt agtagcttca tctttactta 73800

atgactctac atcaaaagta aactcatcat ataaacaatc tatatgctta taaataaaat 73860

ctttttgttt ttccgtagct ttgtttaatt cattgctttt tttacttata aattgactaa 73920

agttatcact catttaaatc ttcctcttta ataaaggtac cattaactgt tcttccttta 73980

cgacctttaa tttcattata agcaaactct aaacactctt gtaatgacat gtcgtgttgc 74040

tgagctaaaa taattaaagt aactacagtg tctccaatac catctttaag agcttctagg 74100

ttaccacgtg ataatgccga tgctacttca cctgcttctt cgtagaattt aagagcttgt 74160

ctatcagggt tgttattgtt caatccttta tctttactcc attcctctac ttgactaact 74220

aaaccttcta gcgtgcggtc ttctgtttca ccttcattaa agttaggttt ttcatcgttt 74280

ggtatatggt cttcttgttc tctatcctct attgtaataa ataaagtgtc tatttctttt 74340

tcgtacttat ttctctgcat ataattatac tgctcatact caggataagg tacacataca 74400

gtatcgtctg taccatcctc ataattcaaa caaacacaaa caatatcttt gccacttagt 74460

ctatcatata atgtcatgtt gtagggctca tctaagaaac catgaaactc ttcaaagtat 74520

tcatccttca taccacttac ctcaatagaa actttttttg ctgatttact tgtatctact 74580

tcactatttc catatatcat agttttttct tcactaatgc cttctagtat caactctaca 74640

ttttctggtt ctaacattgc gctatctaag ttttcaaaaa caatttcaat atttttaatt 74700

tttttagtca ttaataatca ttcctttttt ttagtatata gtaaatatag cacataagta 74760

aatagaagtc aataaaaaaa aacacctact ttaaaaataa gtaggtgtaa gatattttga 74820

caggtagctt gtggaaaaaa tcctgagaga ggactcgaac cccaacgact aggtagctac 74880

aactagccaa taccattact caggattgat agtaacgcta aatagagtca taacgttacc 74940

atagaccttt tctacgcttg gtatataggt agaatataat gattttacag tacccatata 75000

gttagactgt tactctcatt ataaggttaa aaaatgctaa ctttgtttcg cattgtcaag 75060

aggcgttagt taactactat aataatatag catatatttt attgtttgtc aagttcttta 75120

ttccatttac ttttttcttt tagtaatcct tttttaatta gttcttcact aatattttta 75180

tactctttat tttctttgta gaaaacttta gctaaatatc taccaaaaga atcatctttg 75240

tatgtttgaa ttaaaacatc ttttccttct agcatagttg ttgtaaattc cttagcttct 75300

tggtaattat tttgtttctt ttctggtgtg tcgacaccta gtaatcttat tctttgctca 75360

gaatatgttc tcattccgtg gtcaatagtt acatgtatag tatctccatc cactactttg 75420

tccacatgtg ctttaaataa atataaattg tcttctatca tcattaaatc ccctttttac 75480

taatttaaaa ttatccaatc agtattgctt gatgtaccct taactacata tacagatgaa 75540

cctattatag caatttgacc tttatttaca gatatcattt agatgaatat ggtcttgtac 75600

tgaaaagtct acaatgacat gtttatgctt tttctttttt gttaatactt tatatgtgat 75660

aaagaatgat ataatagtta aacatatatt taattttttc ataaaatttc tcctttaaag 75720

aaggtattta ccatctcagt agttaattct ttgcttttaa agatacaata ttctgtattt 75780

ttattcaata tttctaacat attttgcata ctacttgctt tttgtaaatc cgttaagtct 75840

ataacaactg ttatttctgc gttatctatt agaatattac ctatgtaata atttttaact 75900

ccattctccg tagcatgaga ggtaacatta tgatttaaaa caactatacc ttttgatggt 75960

aagtactctg aaaagtataa gtaacaaaag tatttgtgta tctttttttt attctcttcc 76020

attactatta ccatattcta tgaagtttaa tagcctttcg gtataggttt taattttctc 76080

tacttctttt ctttcatcgt cttttcttcc taatcttgtt gtatatttaa caatattaaa 76140

tagcatacag tctataaaac caataatgta gaaatattct tctaaaaatg atataacatc 76200

ttttttacct ttataatggt tcggtgtatt agtggtagaa ttgacattat agtataactc 76260

tagttgttct acatttttca taagcttttt agcataatat aatgtgtcat ctaaagaatg 76320

tgtcacatct aaagatgctt caataatgtt tatctttagt tcttttaatt ctgttgcctc 76380

tttgttactt ccaatttgtg aatcaataaa ttctctagta tccatattgg tgtcctttcg 76440

tatctaaaat aaaaacccta tctagaatat agatagggaa aaggaaagat attatggaag 76500

tgtactataa tgtacacata taatataaca gttcctttgc cttttaatct atatcattta 76560

ttttaacttc ttgtacttta acataatctg ataaactatt aacgaagata ttatcttcta 76620

ctaattcgtt tctattattt gtaacatcat atgagtctct ataaggcgtt tgtactaatg 76680

ctctaactgt aatgtctata tctacatatt ctttactata cttctccatt actcaacgta 76740

gtttccttta gcaagctgat actttttgtg taattcttca tataatttct ccatatcttt 76800

atattttctt acatcttctt caaaatgact taaatactct attaatgtct taacttcttt 76860

aggttctaaa gttataactg gttttaccat tacgcaacat cctcactata ttgtttgttt 76920

aattttttaa tgtcttttac taactcgtct tttaattttt taggtagctc atactttgtt 76980

agagattgtt gttgtcctaa tctataccca tattttgtta ttatcacttc tacagtgtac 77040

catgatttat taatatcgtc aacttttcta gctaataaaa ttaaacactt atcatttata 77100

atattagaag cgtacatacc aacacaatgt gatagttttt ttccttcttg ttttaacttt 77160

tcagttgtat ccgcgggtag aaatttaatc ttagtaccat cacttaagct atacaccttg 77220

gtagtaataa ggtctaattt attactatat ttttgttgta attttaagtc atcgagctca 77280

tttttaacgg ttagatattc atctgtaaca atatcatgct ctaatttgag agaataaggt 77340

gttaaattaa cactttctct agttctataa ccaacaagaa ctaagtctga agcaaaatct 77400

atataatcct tatataagtt gttaacagcg taagaatgta tacgttgtct attgagtgtg 77460

tcataaccta tataatttac catttttcta aaatcagaga acgtaaaatt aagaacttct 77520

ttagtggtag ctttaaaaga aaaagcatta ccaatggtat gagaattatc cgccattata 77580

aaatcatcat cgaacagttt gtgtagatta ggttcactat acaaatcagg aaatctatat 77640

atgataattt caagcatata aaggtaattt ctttgctctt ctttgttaag gtttataaat 77700

ttgttatatg tttgcttggt taatctaaaa gcttcatgca ttttccattt gtttttgttt 77760

ggtactacta aaaattttat atgtgtttcg aagacatttt tgttctcatt gttgtaaatt 77820

ttatcgatat taataacaag tagttttaac agattgttta aattatttgt agcttctttt 77880

cctttgaaaa tttttaagtt gctctgttga gaactctcta tcatagaata tatgtcaaaa 77940

tattttccac tgtttccatg agaggtaaaa taatagccgt tgttctctaa tgtttgcatt 78000

actatctcaa aagccaaatt ctctttttta tacttattta aaataatact taaaagaata 78060

ggtaatgtta tattgttttt taatttatcg ttgttaaagt catctgtgta catattaaac 78120

ttaaattctt tgtgttgtaa tgtgtttgaa aggtgtaact ccacctctcc ttttttatta 78180

ttaaacttac tgtctgttat ttcccagttt gttgttacag tagacatatc ttttaaatag 78240

caagttttaa ttaaaaaagg tgtgttatta tcttttacag gtgttaattt gttaagcgcc 78300

atttttatat tttttaaaac ttcattgtag tattcgtagt cattatcgta agacttacca 78360

aatgcataag ggtcaatatt aataccaaat atactatagt caccctttaa taacacatca 78420

agtatatcat tagttgtatt atctatttgc ctttttaagt ctcttatcat ttttgtaagg 78480

taactattac tgttcctatt ttccgtattg tcaaactgtt ttaatttatt ttcatagttt 78540

gcacggcagt atatattatt acgatagtgt cttttgttat ataaaggaaa ttcagactta 78600

tcgtcacttt ctatatactc actatataca gtatttacgt ctgtaactgt tttacttaat 78660

tcttgtactt ttttatatgg gtcaccatta aatttagtaa gttttttatt tccacataat 78720

gctataaata aaagaaaatt taaagaacta gaataacaaa acgtattatt gatatctctt 78780

aataattctt tagagccaat atctacaata tttttattac ttatttttaa atatactctt 78840

tcttcaccta taaatatact atttctactt actttaggta acttaagaat ttcttcttca 78900

gttaatcctg tttctttata ttctactgac atgtgtcatc acctcattta ttattatata 78960

agtatgataa catagttaaa tttaataatc aacaaaaaag aagaactttt ttacagttct 79020

tctagataag tttcatattt aattttttta gttcttctta cgggtacaat atcgggatta 79080

ctcattaagt ctttgtactt cttagaattt ttaaagttaa tagtattagg cattgctaat 79140

acttcctcta actcatctgt gtacatagta actttagata ttatatctat gtcactaata 79200

tataaatttt tagatttact tttaaaaata atctcatcgg tactagttac ttctttatta 79260

tctattaaat ccatatagaa gtcctttcta gtctacataa acaagtatac aatatttgtc 79320

tgataaagac accgaggtca tatcattaag ttcttgtagt tgtttaatag acacatcata 79380

tttcttactt atagtccata aggtatcacc atttctaacc ttataataaa atttattacc 79440

tttttgtatt aagtctttca ttgttatcta cgcctttata ttcataataa gatgcctgta 79500

ggtaacatat cgtaataaga ataaagttag ctacttctgt atatattaca tgtggtgtcg 79560

tatttgttat taacatacta ataattaaac aagctaatgc aatacccata ataagaaata 79620

aatatttgct agttccattt gtacttttag ttttataaaa tttatttatt tgggataaat 79680

aagctacgat aatactaata gtagccatta tctgtccata ttcaacacta tagttagcta 79740

ctgaatagcc aatataaata acaattataa acataaccat ttctaaaaga ctaacttctg 79800

ttgttctaaa taagtatata ataaaacaaa taatacctag taataaatta atacttactg 79860

atataatttg aaataggggt gcatgtgtta caaataagct tgttaagcta atacttactg 79920

taacaacaat ataaaaccaa aaatagctat ctacaccttt aacattctta tctcttatca 79980

aacctactaa agcaggtata tatcctacag taactaatat agcatatagg atgcttagta 80040

tatgagctaa attagacatt agatgcacct aacttttcta attcccctaa aacttcttcc 80100

catgaaataa cacctttacc gtctgttaaa tataaagcta ctccgtatac gtaagcgtta 80160

aaggaatatg gaactctatc catatcatca tgcatatctg ttgtattcca tctgatgtca 80220

ctagagtaaa ttaaaacagg tttatttagt attttctcgt taatttcaag ctctttatct 80280

aaaactgttg ctacatctgt taattcacca tttacatcaa gataataaat atcatataag 80340

tcgtttagcc tgtcaatagt aatttgtgct tgccttttca tttgaaaaat ttgacctaac 80400

tcggtgatgg ttcctaaacc tccattaccg ctaataggca aatcaataac ataaatatca 80460

gattcctcaa tagcacacgt gtcgttttct acaattcgtt ctgccaactt atgtgagtct 80520

gtattctttt tatcgttaaa tgattgtgag ctagggtcaa aaactttaat accaacaata 80580

ccttccatct cttttttttg tttgattcta tattctttta acccttgcat caacatatcc 80640

gatgcatgat acacctgaag ttctttcatt aaatttgtca ttctactact ccttttcttt 80700

ttcaaactca tctcttagtg tgatgatatc tttattaagt tcatctgaat ctttcatttt 80760

agcccaatag taaaagtctc taagttcagg atttcttgct aaaatatatt gcttaggtct 80820

tacatctctt ccttgtgata agaagtaagc tatatctctc atatatttcc agtctttgta 80880

atagtcagac ttatatttaa acataaatcc tttcaaatct tcaaatacat acccttcatg 80940

caatatatta taagagccat tattatcctt ataccattta taaaattctt cccaactagc 81000

aaactccaac tctttttctt ttagttgtaa tcctacttca tcagcaacat atttcaaata 81060

atcataatct ttctttttca tatttaacgt atttgaaata atatcgagta agaatatatc 81120

gctttttcga tattttatga tatgagggtc ttcttcgata tcaactactt caaacactaa 81180

agtaaaacta tcgtcagcaa tataatgatt ttcaaggaat gttgttaatg tctgtatctg 81240

tcttttagtt aaagtttttt ctaccagctc tttaaataat aatgcgtatt tattcccatg 81300

tccacttaaa tgtgtttttg atttacttgc atatacaatt ccttctaacg ggtcatagaa 81360

cattaatcct aaaaatccat tttctttctt atatccagtt aaagggaatt ggatagtgtc 81420

tggcatattc tctaatttgg tttcttctac ttcattgata ttaaagaact tattatatcc 81480

ttttcctaat actgtatttc taccttcatc aatataaaga cctctagagc tcactgttaa 81540

ttgattccat ttctttttag aaaaagctct ttttgtaaag ttaactgaga acacatctct 81600

atattgttta ttggttttat tttaaaagtt ttactattag gcattgccca aactctatta 81660

atgtccattg cttaacttcc tatctcatga ttaataaatt ctaaatcacc attcacggta 81720

cacaagacat caaaactaat attttctttt ctatcttttg aaatacctgt gtaaactatt 81780

ttaggtatat gactaagggt ctgtaatccc aaaccatcta tatattctct aaaagataca 81840

tgaggtaata aataagcact taattcacta ctgctaactc tactaaaata aatgataatg 81900

tctccaacag gtagttcatc attatacaca tctacgatat catcttcttc aatagtccat 81960

gttgtatgtt ctatatctgc aggtgttaca tgtacaagct gtttaacttc tccttgtaca 82020

gtggactctt tataaaaacc tacagcattt gctttctcta aatattgtgc aataaaaata 82080

ccatcatcac taattaaata aggtgttcta ttttgaaaat ctatagaccg ttccatatct 82140

agtttttcat aaatatcttt taagtactta ctaatcttat taacatcttt tgttttaact 82200

ttatttgttc ctactttaac ttttaattct gtcatttata ttccccttta taagtatttc 82260

ctaactggtt ctgaatagtc ggtaatatct tttactcttg ggtattttaa aatgctaaaa 82320

gcaataatac ctaaggctac aataggtgct aataaaacca agccccagaa tgttaatact 82380

gtttgtaaga aaaacattac actatctact aaaaaccatg tagctactac tagtaatgtt 82440

gtaactgtaa ataaaaataa cttttcccaa aatccacctt tttgaaactt ctttgataat 82500

tttttcataa taatatttct ccttatattc caattgcttt ttttgctaat gcatctacat 82560

attcattcca tttgttatta tcatgagcct ttacttttat aaaatttata tctataaact 82620

ttgagtattc ccttagcata ttaatatatg ttttacttaa attgttttta gttttccacg 82680

aaccttcata ccattgaata agtcctatat aatctacatg aataatagcc tgcttataac 82740

ctagttttat agcctcttca ataccataac aacaagctag tatttcacct gcaacattat 82800

tatacttaat taaattacta ttttcaatag gtttactgat ttcttttaca atgttctcat 82860

ttttatctaa aataatagct cctgctccaa caagaccttt attataagat gagctaccat 82920

ctgtatatat taatgcagtc ttatgcatat ttatgccttt ctacaaagca agggaacatc 82980

tcacttgtat aaatctcttt gtagtcttgt aattttatag tagagaaatc aaaaaactta 83040

taacaatgtt cttctgcttc gatatagtca tctgcaataa cattaacttc aaaaccatca 83100

actaaaataa cgaacaattt cttaaacatt taaaaaaccc ctttataatt taataaggta 83160

cttaattaaa tcaatttcag tgtacttttc tgagtgttct agctcttcta atttttcttt 83220

tacttcttca agtctgtatg actcttctaa aagttcaaac tgctctaata atgtgatact 83280

atcaaattca ctactattaa taatgttgtg tatatattct agatgtgtgt ctttaataac 83340

gtttgttaag tcatcaccag tataataatc ctcgatatac gataggtctc ctaataactc 83400

agccatactt ctaataatac tatatttaga tatattaggg taagattgat ataaacaatt 83460

atctaattta ttacttaaat gctctactac tttttgcatt gtattacctt tttcttcagt 83520

actatatgaa attctaatat tagggttttt agaatcataa tcaactaaag aactcctatt 83580

agtgtttaat aacttatcta aagaagttaa aataatagct ctatcttcta tattatctaa 83640

ggttaagata gtatctataa tagtataaaa tgctttgtct cctattgctt tattaacatc 83700

ttgaagttca aaaatattaa tcatatcctc aatctcatga cgctcaacaa agttaataat 83760

agattttgta aatttattca tcaacgtcaa cctctttaaa taattctaca ctattagtat 83820

ttaaagcttt ttctaatttc ataagattag cactcttagg ttttctttta ccactctccc 83880

aataagaaat aagtgagtag tgaactccaa tctcttgtgc taaacttcta actgtatgac 83940

ctttttcttc tcttactttt tttaaattta atactttagt ctcttccata ataaaccact 84000

acctatcttt cttcaatttt taaaatacta tagttatttt tattataagc atacttattt 84060

aaaacgtcaa gcgttttttc tttagcctct actttacctt tagctttcat attaacatag 84120

aaaacattac ttttatttga acgtgtatgc ttaatatata ctttgtactg cgtaatctca 84180

ctttttaata cattacgttt aaaccatttc tttaattttt ccatttatta taaccacctt 84240

taaaacttat atatgtattg tagcatatga taaatacatt gtcaacttaa aaataaaaaa 84300

atactaggga aaattcccta gtacattatt tccagttaat acgaccccaa tacttctctt 84360

ttagcatacg ttcccacttg tcagtgattt tacatactgc catatagaag ttaccagctg 84420

acgggtttgt aggatattta aacctaatcc accagtagcc gtctgcttta ataacttggt 84480

caaagtttac atattgacca ctataaataa atgattcagc acctactatt gaacccctta 84540

aacctggtgt gcgtcttacc ttaatcgttc tatcagcagt aaatttacct ccccaattcc 84600

aagttgtttg tacctcgtct ttgaaattag gttctataaa ccacatagga aagtcgtaac 84660

catgggctct aacggtagct ttctcccagc caccgcctcc ttgagcatct ccccaagtcc 84720

aacctcctcc taaccaatta ttttcaatta ctataatttg gttttggttt gcacttagta 84780

cccatgagac atgaccataa ccgcccccat atgaattatt aaagataacc atagtgcctg 84840

gtttaggaat gtaggatagt gtattttcta ctactctagc tttatctttt aacatagctt 84900

tattatccca tggaatgtta catgcactct ctccacctaa agaataacct gggaagagct 84960

tgttaaatcc atagttagct aagtcgtaac attgctgacc ataccaacca tcaaagtcta 85020

ttgctttgcc ttctagactt tttaaaaatc gaacaaattc acttctagtc atcgatgctt 85080

tcaaaagttt tcactcctta tttccaatct atttttccaa aatatttttc tttcttaata 85140

cgctcttgtt tatctgttat ctcacataca gcacaataga aataattttt actagagcct 85200

ggttttggat atttaaatcg aatccaccaa tagccgtcta ctttaataac ttggtcaaat 85260

tcaacccaat catccttatc gtatagccat gaatctctat ttactatagt gcctttaagt 85320

cctggagatt ttctaacttt aatagctcta tctggataaa aagtaccttt ccagctccac 85380

atagttttag tagattgtgt ttttactcta ggctcagcat tacctgattt ctttacatct 85440

actgacttaa taactttctt gtaatactta gctacttcct tatctaagtt actagtgttt 85500

ctacctaatc cacaagcttc taataagtta cctgggtctt gcttgtcgtt ttgaatgtct 85560

tggtgacctg gcatatttgt tttgtaatca acaccccagt attcagctaa ataagctaag 85620

acacgagctc cattgtctaa tgatttttta gaacgttctt tatcactaaa gtaacaaatt 85680

tctacaccaa tagcaccatc attagcgtta attccgtacc ataggtcatc cataggagcg 85740

ttatacaaca catgccaagc tttttctgta gtaggaacac atatgatagc ttctttatca 85800

tctacaaaga tatgtgcgga tgcagtggaa gcccaatcaa tgttatatgt atttttgtaa 85860

taatctacat tattttgagc tgtagtatta atattccctg tatcatgagc tacaataaaa 85920

acgggttttt taaccgccat agcttgacct gtgcgtcttg ttccaatagg tagtaaatca 85980

tatctaacac ttacaccttt ccaaatttct atcattactg ttcacctact tcttttgggt 86040

tatcttcttt atctaattca gacactaagt ctttttctac tttaccatgt tctaatggct 86100

ctgcatgact tgtatctatg tcttcattat taactccttc aggagccatc ggcatctttg 86160

taggaggtaa ctctgaggta ctattcattg cttcactctt gtatgttaaa gctttatctg 86220

ggtcattata atctctaggt ttgttaaagt cctgtacaat agggctatcc gctatacctt 86280

tagtgtcatg acttacaaga acacctaaac cagtcaagaa actaataact acacctgcaa 86340

ttgcagtgcc ttggtttaca atatcttctg cacctttgat tcctagtaaa ctacatacac 86400

taacaataaa cgtagctaaa acaggtacaa aacctgtcca aaatgtagca ctttttgctt 86460

ttgcagtaat attgttacct gctattaata atggtttttt atcttttttt gacataaaaa 86520

aataccatcc tttctgttat tgtaaagcta ataataatat aacaaaaaga atggttttag 86580

ttattaaatt ttaagttatt gttcgttaat ttgagaaagt gttttgatta cttctgacat 86640

ttgtttatta tctaagtctt ctaacttagt gtgtggaagt aaatctaatt tatcccaaat 86700

atctttttta gttgtgaatt tttcattaat aattgctcta ccgattaaac tttcggtata 86760

ataaatttgt tttgcagatg ccatattagt atctaccgtt gtcaaaaatt tataaaactt 86820

tataaatcct attccttttt caacgtatcc ccttttgagt accctcatca ttactgatta 86880

ctcttatata ctctactcgg atttgtatga tactccaaag gcttaaattc ccatacaacg 86940

aatggtacac atatttagta tcttatttgt gataacttaa atattatagt tagctaaatt 87000

aatactagca ttaaggtctc tatcaatact aaaaccacat ttacatttaa atactctgtc 87060

tgatagtttt aggtttttat ggatactacc acatgtagaa catgttttac tagaagggaa 87120

aaatctatct acaataacaa gttcaattcc ttgtctttca catttgtatt ctaattgcct 87180

tctaaactca taaaatcctt gtttttgtat tgctttagct aaatgtctat tcttcatcat 87240

cccttttaca ttcaaatctt caataacaat tcttctaggt ttggttttca cgatagaaga 87300

tgttacttga tgtaaatagt ttttacgaat attagacaat cttcgttgta ggagtttaat 87360

ttgtttttct agttttatga tattgcaagt tttgacaaac gtactccctt ctttattttt 87420

ttggtatttg aaagatacct tacgttgcaa cctacgtaat cgtttttcta attttttaac 87480

ctttattgtt ttattaatat taccataaat agtaccatct gaacatacag ctaactcttt 87540

tatccctaaa tcaataccta aggactcgtt ggtcaaatct tcatatttat tttcttcttc 87600

tatagagata cttatatacc agtatttacc atcaaaagta attctaggat tgtagtactt 87660

agtgtctata ggtagttgtt cagaagttct aacccaacct accttttcta ttagtacttt 87720

tttctctttt actactagtg catacgtgtc attatagaaa ctaggtcttg ttttcttttt 87780

agatttgaac ttagggaaac cagatttctt tttaaaaaat tttttatatg cattgcatgc 87840

gtctttaact gcttgtttag gaacattgtt acttacttca tgtaaccaac taaactcttc 87900

agttttcttt agttgtgtaa tttcttttct taatactgtg tcttgtataa attttttacc 87960

ttgttcgtaa ttttcttgct gttttgctat agtccaatta tatataaatc gtgctatacc 88020

agctgattta cataatttta atttttgttg cttggtaggt ttaagtctga cttttttcgt 88080

tatcactatt caattcacct actatttttt tagcgttgtt cttgtgtctt atttgattta 88140

cttctaagaa cttatttggt tttatttctg ttttttacgg agcatatagg atttgaacct 88200

atgagtgaaa taaatcacct attgagttag caacccaacc tcttaagcca cttgagtaat 88260

actccttagt ataattaaac atacatacat aaaccgtctc actggtaagt aacatactag 88320

acctattgtt aagttaatca ctacgcttga ctctattagg tagctaacct aagtccatct 88380

cacgtaacct attaaagcag tacaaccgta tggttgatta tgtttaatat tgtaatgtga 88440

tactaacata ttaattagta actttcacat ggtatgaaga attttaacgg catctttata 88500

tttttaccaa ttattatttt gcaggtttat gctactcgta ctagtatcgt atgttatcaa 88560

acatttttca atgctccaac tgcatgtact tgttaaggtg tatttgtaaa ggataccacc 88620

aaaaccccct acaaaaatta agcccatcgg atactatact ttataaacct aatacattac 88680

tgctaagcat tccgattgta ataaacatta ctattgacga attaccttac cgacgtatac 88740

cgataagttt taattcgttc gacaatctta cgccttacag gtaccaccct gtttaaatca 88800

gccattatgt atgtatgttt aattatacta catttaaagt ataacatatt atcattcatt 88860

tgtcaattaa aaaatgtgtt acgttttata gtttttttat actagggtaa aaacgtaata 88920

aaagacctag tttcgacaaa taaaaataag gagaagaatg tttattatgc aaaatgaaat 88980

tatagctctt tatgagctta tatataatat aacatactat tttgagtttg tcaagttatt 89040

ttttactttt ttatcttgat aattcttctt gtactctatc ccaatatttt tctgattctg 89100

ttctattatc ctcaatgtga gcagtagtac atttacattt gatacagtat aaatgcttta 89160

tatgtccctc ttctcttttc tgagctcttt ttcttggtac tgtaaaagta ttaccacatt 89220

ttgaacaaac taaattactg tggaacattt tctgtctttt tttcatgatt atcaatcctt 89280

ttcttttaat ttgttttata tttagattat atcaggtgtt gagtattagg tcaacacctt 89340

tatttaatgt ttctagttaa tttttaatac tcaagcttta agaaacaaga tgggtattct 89400

tctgatactg gagtagtata tttatcttct aagttatcta gggctttgaa taatttatca 89460

acgtactcaa tatcagttcc tatagtgtca ataatttttg tattatctat tgtactttga 89520

ggaacgttat tacttttcat tttctttaat cttcgagtat gttttgattt aatattgaga 89580

ttttgagaat atagcatttc tttataaacc tcattccatg ttttaccaaa gttggggttg 89640

ataatactac taattttagg tgttaatttt ctaacccttt tatttgcttc ttgtttccaa 89700

tcattatttt caggtctttt ttgtaaaaac tctagtttat tttctaattc cataacttcg 89760

ttctctactg aagataacct atcattttct ttttgtaaat cagtcaccaa tttatttaat 89820

ctttctgact cctcaaagta cttaagcatt tcttttttag cttcttgagg attatctata 89880

atagctttag caaaatcatc attcatgtac attccatact ttctaatatc aggtagaact 89940

tctgaagtta cccaacgctt gaatcgttta gctgattcta gttttgatga aaagattaaa 90000

ctgtataaac ctgattcgtt gattaatgtc acagtcctta attgacctgc gtacctaatt 90060

tgggtacgta gcttatcttc atcctctgca tggttattta tagcgtttcg ataatttgaa 90120

tatcctaata tcttagctac ttcgttacct acaaagtaag tttgattgtc tttaactact 90180

gttcttactg attctccttc aaaattaaac attaattggt tttccatgtt acatcagtcc 90240

ttttctttta attgatactc ttattctaac gtaagactta ataaatgtca atgctttttg 90300

ttaaatttta tgtaattatt ttgagaaatc cttttatatc aagggtttta aagatttttt 90360

tacctatttg gaaaataagg aggattcctt atatatataa taaataatta taaatactaa 90420

aataataata ctagttataa taattaataa tatatatagg aaagtcaaca aagagtaata 90480

aaaaaagtga cttacttaaa agtcactaat tttcaaatac taacttaaat gattctatga 90540

ataaagggtt aatgaatact gtatcagaat taatatcctc agagactcta actctaactg 90600

atgcttgtcc atgtcctcta attgttccat ttatttctct ttgtgtatac tcaatatcat 90660

tatcagaaat taaataatac tttttaccac taatcattgt tatctcagca tgctttacca 90720

tatcaaaact cctaactaaa tttattgaaa atgaaagtta taatagaacc taacaccagt 90780

aataatactt tttcagtagt atccttcttt cttgtatcct taacaactgt gttgttagtg 90840

agctctttta tcttttcgtc taatctatct agctgtatgt aaatagatga ttgtttctca 90900

ctattaacag ctacttcttt gtctaaacta actaccattt ttcttagttc atcaacttca 90960

ttttctaatt ccttatacgt atttttatca atatagctac catcttgtat tttatctttt 91020

atcttatcta cttgtccgac aaggtttttt agttcttcat tcaactaaag tcacctctta 91080

atgtctaact tttcagattc cgaatggacg tcatagtttt cgaaaaagtt attaataatt 91140

tgcatataat cctcagtaac tatctcacca tatgacgttt tagtatttat ttcaaaccta 91200

agcttaccaa actcatggag gtctatttct ttaataacgg tattaggatt atcagatggt 91260

atgtaataat aatcaaaata tataatagag ccgttgataa gcaacctatc aatcctatag 91320

acgtggaaga attttctatc tcgtctaaag tgagctaagg catctttaaa ctctaatttt 91380

aatatatctt tatacttagt caaatcaact taccccctta taattaattt tgagctacac 91440

tagttttgtg ttataatagt tattgtagta gcagatatga gtattacgtt taataaaatt 91500

agcaaccacc aactacctgt acttattaac cataatgaaa aacaagataa tatataaaca 91560

accaccaaat agcctatata tttcatagtg tttttacact cttttaatac tactacgtat 91620

gctagtgatt tagataagct aaacagaaag taaaaataaa aaataaaaag aggtatagct 91680

ataatgcttg ctagtataac cactaattac acctaatttc ttttagctag ataataaaat 91740

cttatataat acaactttaa tataacattg aaacctgttt ataaatcaac aatgttacat 91800

taatagtgta cggtatattt taaattagga ggactgaact aatagggtga ataataacat 91860

agctgtattt atatttaaaa ctctaataat tattattttt attttgttta ttttgtctat 91920

tattaactca ctgtcattaa tatactctat tcgacctagt acagttatga cttactttat 91980

attcggtggg atagtttcta atgtggcatt aacaataact gataaattat tattacacaa 92040

agaagacccc ttacccgatt atattctaaa agaagtagag ctaaataaca atgaattaca 92100

agtactaaag aaaattgtgg agtcacaaac taatgtttct gctgaggaag taagagtaag 92160

agcaaaagca caacgtcgaa tactaaaaga taaaaagaga gatgctgtcg atgaaaacga 92220

agaaggacat taaggaacaa cgtaaagagc taaaagataa tgcaaccgct gtttccttaa 92280

caaaaaaagg agataaacgt attgcaagtc ctagtagggt gtgttgttta tgtggtcaat 92340

ctctttcagg gatgaactat actaaaggta aatctatagc taaagttaat cattttcatt 92400

tacagtattc taagtactta tattttgaca tgtgcgcaga tattaataac tgttacaaga 92460

atttaaagaa agtaggtgaa ttgatagagt gagcgctgaa agtttaaggg atatgttatc 92520

taagaagaaa attgaagacg aagataaacg taaatatata gctgatggat ttatgtcagg 92580

tattactaaa cttatgtatg actttaataa aaagattgat agaggggaaa tagaagtaag 92640

agaccctaat gatttgtaca aagtatttgt tatcttccaa caaatgcaaa acttaattac 92700

agatggttct gatggtggtg gtgctatacc gcaattatca agaccacaac aagagctctt 92760

tgatgaaata acaaatgaga atagtaaagg tgagaaagaa gtagatttag agaagttatc 92820

tcaactatct gctgatgata ttactgctat gattattgat aaagaaaagg ttatgaacga 92880

agagaactca aatacattct aaagaaaggt gtatatgaat ggacggtaaa gaattattaa 92940

aaataacaca agaaacattc ggtacacaaa atgttacgca agaacaagtt gaccatatta 93000

tcaacatgtt aaaccctagt acttatatgc taaaatatca tacgttacga ggtcacccga 93060

taacttttag tattccaaac agggacagaa gtaaagcaca agctcataga ccttggcaag 93120

tccgtaaaca tactgtgcgg actataaacc ttttctaaac ttggaaactc taagtgctta 93180

aacaagcata tgacaatcaa gtgctaaatt tagtagtgat actaataaat gcctaacgac 93240

taaacttact ggtaaactta taaatggata agtgtagaac agtataaaag ggaaaccgta 93300

acgaaagagg gcgtatacac ctaaatgtat acgtatgata tagtctaatc ccctaataaa 93360

tatcgggaaa ccgagggtaa taaatgatag taaatgacaa ccatcctaat aaagttgtga 93420

ttaaatcacg acagcttgga taaagctttg ttcaagtaaa actttcacta aaaggaaaaa 93480

ctctaaggga taatatccta tgacaattcc ttgctaaaaa aatgcctaac gactaaattt 93540

ctaggtagat aaacgaatag gtttattgag aactagataa aagggttaat gacccgtaac 93600

gtgaaagagt taatgtcttt tcattagcta agatatagtc taaaccgatt cttaaatgaa 93660

tgttaaagta ttacgaaagt aacggtagta attgtaagtg agatgggtgt aatggaaatg 93720

gtacattttg ctgatatgca tagttatgca agtgtaaagt gtctatacac attccctaga 93780

ttataagttg gggaattaaa actctgttaa acggtcatag gaaaataaag aatatcctgg 93840

taagagagac taagtcctaa tggatagagt taataccgtg ctaaatcaac ctaataagtt 93900

gtaaatgccg aacgactaaa tttctagata gcttattaaa aggaataagt gaaaactaga 93960

taagaaagtc ttgacaaaaa taccaaagta agttaatata ttaaatagga ggtggaaaaa 94020

caaatgccta gaaaaaaaac acatgaagaa tttgtaaaac aagtagaaga catagcagga 94080

aatgaatatg ctgtaatagg gtattatgaa tacgcaaatc aaaatataaa aatgtttcat 94140

aacgaatgta aggaagaatt tgaaataaga ccaaataatt tcctacaagg taaaagatgt 94200

tctgcttgta gaagtaaaag aataagtagg atacaagata aaccacttag tgaagttaaa 94260

agacaactaa aagagaaaca taagggtact atagagatta taggtgagta tacaaatact 94320

cacactaaaa cagattttaa atgtttaaca tgcaaccata ctttctcttc agaacctaat 94380

tctgttttaa gactgagtgg atgtcctaaa tgtaaagttt ctaaaaggga aaaattaata 94440

gctgaattcc ttaaagaaaa taatatacgt tttaaagaac agaaaagatt taaagattgt 94500

gttcataaaa gacctctaat atttgatttc tacctattag atttaaatac tttaatagaa 94560

tatgatggat tacagcacag taagccaata gattattttg gcggtgttaa agcttttgaa 94620

gaattgaagt atagagatag cttaaaagat gattacgcaa aaagaaataa tattaggatg 94680

gtaagagtgt cctataaaca aaaagagaaa gagataatag aagaattaga aagtgttttg 94740

ggtgtggtaa cccgtcaaga aagtaaagca gagagctcaa caccaaaaag ttgagttaag 94800

atatagtcta gtccgtatgt aaatatcacg aaagtgacgg tagtaacgac taatgaacag 94860

atgaagaaat tcgtacaatc aagacttaat ccagtattag aaaaacctta ttttagagat 94920

attgttaatt gggataagga ctcattaggt tataaacaaa taagaaattc tagtttattt 94980

ttcagaacta gtagtaaagc tagtactgtc gaaggtgtgg ataggtaaca agtccacatt 95040

aaactctgtt aaacggggaa acccctaacg taaagacgag ggcaatcccg tgctaaatgt 95100

tgactttata aaaagaatat gatataatgt atttataagg ttagctaaat gcctaacgac 95160

taaatttcta ggtatctata caaaagggta tagtgagaac tagataagaa aaccgccaag 95220

attattttta ataagtaaat aattttatga aaaaaagcgt gtaaagcata ttactaatga 95280

taagaataaa gtacaagcct taattaaaga ttatcaatat atggacttac atggatgagt 95340

tatttgaagg ggaatataaa tttttagaac cttatataaa tagtgacaca gctatcaaag 95400

gaactaatat tagaacttct tggcggaagt aaagcagaga acctttcacc taatagaaag 95460

gttatgatat agtctaaacc cactcttaag taagtgttaa agtactagga aactaggggt 95520

acaaattgat tgactacctt tcacttgacg agtacgaccg tgtaaataat ttagctgaga 95580

gctcagcttt agaatctatg tcaagttcac cttttaaaat agtaagaagg tggtctacac 95640

caactgtaag agattatggt atagataaac tgtataaaca atcagaccaa tggttttatg 95700

gttatgattg tgaacactgt ggtcatttta atgaaatgaa gtatgctgat tataaacctg 95760

atgacttaga aaatagtggt aatgtattac tagtaaatcc agatggaata gatgagatag 95820

ctaaaactgt ccaagatggt acttaccaat atgtttgtca aaaatgtgga aagcctttag 95880

ataggtggta ctctggacgt tgggcttgta aatatgccga gagaacagaa aataataaag 95940

gtattcgtgg atactatata agtcaattaa acgcaacgtg gataagctgt gatgagatta 96000

aagaaaaaga aatgaataca gaatctaaac aaagctttta taactacatc atcggagccc 96060

cttttgacga tgtaaaaatg aaagtaacag aagatgatgt attcaataat aaatctgaaa 96120

ttgcaaaaac acaattattt aatagagata aatacaaatt tatttcttgc agtgttgact 96180

ggggtaattt tcactggtgt gctgtacacg gtatgacaga agatggtcat gtagatttaa 96240

tacgtttatt ttctgttaag aagaatagta gacctgatat ggtagaagca gacctagaaa 96300

gaattatatt ggagttctct aagtacgacc ctgatattat tgttgctgat aatggtgatt 96360

ctggtaataa tatccttaaa ttgattaatt tttttggtaa agataaagta tttggttgca 96420

cttataagtc cagcccacgt tcatcaggtc aattgtacgc acagtttaat gagaatagta 96480

atacagtaac tgtagataaa ttaatgcata ataaacgtta tatacaggat ttaaaagcta 96540

aacgtattag tgtataccaa caagtagatg aagagttaaa aacttatctt aaacattggc 96600

aaaacgttat tataatggat gaagaagatg ataagacagg agaaatgtac caaattatta 96660

aacgcagagg agacgatttt gtaatatggt cgtctataaa cagtgttaaa cgggcatagt 96720

aaaataatgt atagaaaaac aatatactgg taagaaaccc taaatctgac tatacacaga 96780

cagtgggaac caaccgtgct aaattcttaa tttaaatatt aacattatat tttttaatgt 96840

tattattaaa ttaagataaa agcctaacga ctaaattcgt tattattaac gtaagagatt 96900

aaaataattt attgagtata ctaaaaagga gggtagttaa gtggtttatg ataacgagtg 96960

gtttattaat agaattaaag atgttagacc agaggactat gaagaatatg aatttttaga 97020

tgactatgtt aatcagtaca caaaactaag agctattcat aaaaaatgtg gtaacaaaat 97080

acttataaca ccatcaacat ttatgagtaa acgtaagaca ggttgtaata catgttctca 97140

aaaaagagtc catagtaagc aaagaaaaac acatgaagaa taccaaaagg aattacctga 97200

aggtataatg gctataacaa aatatgaagg tgcatttaag aagataactt tacactgttt 97260

cttttgtgat agtacttata ctattactgc aagagatatt ttaaagtata aacaatgttc 97320

gagatgtaac aggagattta ataggacatt ggaagatatt aaatttgaag tacgtaaaga 97380

aacgaaagga aactatgaag tagtttcaaa tcattataaa aatgcacaca cccccataga 97440

aataaagcat aatgagtgcg gaaaaacata tcggggaact atggcaaatt ttagaaaagg 97500

tagaagatgc tcacactgta gaaattccat aggtgagaaa ttagtagaaa gttatctaga 97560

gcaaaaaggt ataacatatg aaaaacaaaa aacttttgaa ggcttaaagt taataaataa 97620

cttatcatat gatttttatt tgcctgaata taacttactt atcgaatatc aaggtgaaca 97680

acacgttaaa cctgtcaagc attttggagg agaagaacaa tttaagctac aaaaaaagat 97740

agatagtata aaaagttctt atgcaaaaga taacggttat gagctttttg agatattcta 97800

tacaactaag gattacaaaa gtatagagaa attgttaaac aataaattat tttattcgta 97860

aagcactgag ttatcaattt agataactaa gatatagtct aatcccctaa taaatatcgg 97920

gaaaccgagg gtatgaaatg cattacgcac agtcttcagt aattggttac attggtctta 97980

ctcgtttaaa agaattgtat gataaaggca acggtacagc attcacatcc acttttatac 98040

caacggatta taataataca caaaacaact cgtctaatga gttctatttt gatgaataag 98100

aaaggactga cgacttgaca aatatattaa attatgatac aatacaagaa gatgatataa 98160

gcaaggagac atttaattta ttaattgaag agcctttaac attatcatat gtttctatac 98220

atagtgattt tttagataat aaatacgatt acatatataa atccttaggc tttgataatt 98280

tcatggactg ttatttatac gtaacaagag aaccagaacg tatatataaa ggcggagcta 98340

aagatatagg ctcattgaat aaagtaaaaa gaactgtagt acgtaatggg aaagaaattg 98400

aaatgacaat ctatgaagat aataaaaacg atgataaacc taaagagagt aatagtgaag 98460

aaccaaaaga acctaaaact gctaaaggtt ctagggttat tactcacggt gatgatgaga 98520

aacctaatcc taaaaagatt gccagttctc tatctacctt aaagaataaa ggtgtgaaca 98580

ctgaccacat agatggcaac gcatcattat ataaagaatt tgtagatgat aataataata 98640

caataggact agcttccttt aaagagacag attctgatat tatattacat ggatatgtat 98700

cagactttga aactactggc gtaggtgcta ggtctataat agagttaatt tatttagcaa 98760

taaagaagaa caagaacgct gttgtctatg ctatagaatt acctcaagct atagagttct 98820

taaaattgtt agggtttatt aaaaataaag attactatgt attaaaaaaa caagatataa 98880

agttattttt aggtgagtac agtgagctta cttagcactg tactcattta tacaattata 98940

tatataagta ttattatatt agtagttgta aatgtagtaa taagagagaa aagaatgtac 99000

aatactagga agttgcttat acaagtaaaa aaggatatta taaataactt aaaaaaggaa 99060

gatatgaatg attaaagata ataatacaaa aacattggaa gagttaatta caccaatttc 99120

tacagaagaa aaagaggata aaattaaaga gttcagcaaa acattgtgtg aaatgattag 99180

taagttatat gagtcttata atgtgttaag acaagaccct attgatgaaa cacaaagatt 99240

agatggttct ctaatggtat ttcaaagtag gttagacgat gtattaacgg gtgatgaaca 99300

ccaaaaactt ttcaagttag cctttgatta taacattaat atctttgaag ctaacaaaca 99360

atttaaaaaa gatgtacaaa acggaaaatc tatcaagtta ggtgatgttg ttgtaactga 99420

cacagcttta agtaatgttt tatctagtaa tgagcttaac gttagtatta catttatgtt 99480

aagtaaagac tacgaagaga agcaacgtat tgaagcagaa gaaaaggaaa agttagataa 99540

gttataatag atattatgag acctttatgg ataggtagga ataaataata tgaaacgtaa 99600

gtttagtagt aatgagatta ctataacact tataactatt gtagttgctc tatttatagt 99660

attaattaca gtagcattta acaagtacca aattgctaaa gaagataagg acagatatca 99720

aaagctagta gaaatttatc aaaaagcaga tgatgatgac ggtaaaacta aaaaaaggta 99780

tgttgagaag ttaaataggg ctgaggaaga acttaaaaag gttaaagaag aaactaatta 99840

taaaggttat aacgataaaa cagaaaaaga aagagataaa gaggataaaa gtgtaagaga 99900

acgtatttat ggtaatgata aggataaaga tttagtatta gtaaataata aggttgttgt 99960

aagcaatgaa gttactagac ctaagataat agaagataat ggtgtcagta cagttgtagt 100020

acctcctgtt gtaagtcctg ttgagccacc aagtgaacct agtatacctt ctcctactat 100080

acctaatcct attaacccta atactattct acctaaacct agcatcccta cccctaaccc 100140

actacctcct atagaacctg aaaaacctat agaacctgaa aaacctatag aacctgaaaa 100200

acctatagaa cctgaaaaac ctatagaacc tgaaaaacct atagaacctg aaaaacctat 100260

agaacctgaa aaacctatag aacctgaaaa acctatagaa cctgaaaaac ctatagaacc 100320

tgaaaaacct agctcagata ctacaatacc tttagttcca ttggaaccta gcacacctgc 100380

agatgaaagt aatgatacta atggagaggg ataacctctc ctttttttgc tatattaaaa 100440

gagtaataaa ataaacatta tagttggtga ttttttgata ggattaaacg tacttacagc 100500

tatatccgta gtttttgctt gtgtaagtct actagcacta atggtatttg cgtatattaa 100560

aactgaaaaa agtagtaagt tggttctata tttgatatat gctataattg ctataggttc 100620

ttatgtagta ttaacaatgt ttcaagccac gtcaatcatt ataaaaaatg atgtcataga 100680

ctctattgag aatacggagc agtatgtagg gtttaataac cctttaattg tttttggtat 100740

aagtttcttt ggagctgtaa taggcagttt ttggttttta gttatgaaga ttgtaaatac 100800

taggaattta aaaaataaaa aattaaagga ttgaagcatt tgctattttc aaaagacgat 100860

aaatgggatg aagcaaaaga ctttataaaa ggtcaaggat tagcagataa ttggatagaa 100920

gtagtggatt attatagaca gatagatggt aaacatgtag ctatgtttat tgctattgat 100980

aaagttaaat atatggtact agaagctaca aaggataata aagtaatatt ggtagataag 101040

gataataata ttgtgttaga ggattatgat attgttatgg aaagtaagaa aatgttttac 101100

tatatagaag aaccattcga agtaaagata aatattccta aacatatcca agatattacc 101160

tataataaca ctgttatact aactactatt cgaggaggta aataaaaagt tgcctgattt 101220

atttaaaagt ctaaggttag gtagtatgta taaagaagac actgaagacc ttatggttcc 101280

tttagatgat ggaatacaag ctaacattag acaaatagaa caagatacaa aagagatgca 101340

agaaattact aaatctttgt atggtaaaca gcaagcttat gcagaaccat ttttagaaat 101400

gatggataca aatcctgatt atagagataa gaagagttat atgagaaatg ctcataattt 101460

acatgaagtg ttaaagaaat ttggtaataa ctctatatta aatgctataa ttattacaag 101520

agctaaccaa gtatctacat actgtaaacc tgccagatat tcagaaaaag gtgtcggttt 101580

tgaagttaaa ttaaaagact tagacgctac acctggtatt aaagaaaaag agcagatgaa 101640

acgtattgaa gaatttattc ttaatacagg tacagataaa gatatagaca gggattcatt 101700

ccaagagttt tgtaaaaaaa tagtaagaga tacttacacg tacgaccaag ttaatttcga 101760

aaaagttttt agtactaaga ataagactaa aattgagaaa tttattgcag tagaccccag 101820

caccattttt tatgctactg ataaaaacgg taagataatt aaaggtggca atcgatttgt 101880

acaggtcata gataagcaag tagtagctag ttttacaagc agagaacttg tcatgggtat 101940

taggaaccct aggtcagact taaattctag tgggtatgga ttgtcagaag tagagattgc 102000

aatgaaagaa tttatagctt ataataatac tgaaagtttt aacgataggt tcttcagtca 102060

tggcggtaac aataagttac aattaaaata aaatagaaaa tatatttaat ataaactttg 102120

ccgtgcatgt ttagtaataa gcatgtatca agggttaaat gctatgaaat cctaaagctc 102180

aattaactaa aacagaaaga gaaatcttag atggaaaagt tacgaaagta gaaaaaataa 102240

ttgagatact ctaaggttaa atcctaagga gaagaacaat ggaagtatag cagggaaagt 102300

cctaaatgag cttagagcgc acatggaaga ccctcaacga ctagggcttg acgagccaag 102360

taaaactcca aactactggg agaagaaaaa tccttatcct attaaaagta ggaatgacaa 102420

atagtctcca cccgtactga aaagtagggc tatagattaa ctataggaat tggaagtggt 102480

gttccaattc aaagaaagtt aaaatttata aataattaaa aatttattcc aaataactgt 102540

tgacaacaca cctaacttat gatatattta tattataagg aggtgggaat acaatgtcag 102600

aggaaaaata taaacgtatt aatattagat tattaccaac aaaagaacaa gaagaattaa 102660

tgtggaagtc cgtaaataat gttagattta ttaagaatta ttttattgct cgatgttacg 102720

aagaaaaaga taaaggtact tttataaatt tgtctttgga aaaagacttt aaaaaagaat 102780

taacatctat tactaaacta aatgaatata aatggttaac cgaatccgat agacattcta 102840

aagtagtagc aataaaagat gttttgaatg gttttgttag gtactataat ggcatagcag 102900

gaaaacctaa atttagaaag agagggctaa cacctaatac cttttctgtt agaaatgatg 102960

taattcctag tggattatgt aggtttagaa gagatgataa cacatttaaa gtatctgtaa 103020

taggatacat taggtattct aaaaaaagct ttaataattt caaacatata tttgatatta 103080

tagagaataa cgataaattt tattctcctg taataagaca tgatggtaag tattggtata 103140

tttcattgtt atataaagat aacttagtta caaatcaaaa accaagagag ttaactgatg 103200

aaattatagg tatagattta ggattaagaa cattaatgac ttgttcaaat ggtagtaaag 103260

ctagaaatat taatttagat agaaaagttt taatactaga aaaaagagaa cgacgattac 103320

aaaaacaggt ttttagaaaa tatgatatga ataaacaagg tagtaaatat gttaaaacta 103380

aaaatattat taagttagaa cgtaaaataa gacacataag aagaaaactt aaaaatataa 103440

gaaataatca tatacacaca gaaactaaaa aaatagttga aatgttaccg aaagaaatag 103500

ttatagaaga tttacatgtt aaagaaatgt tgaaagataa atggagaaga catgaaatac 103560

aatatgctaa gttctttgct ataagacaaa tactttcata taagtgtaaa gacagaggta 103620

ttctactaac tgttgctaat agatggtacc cttctagtca gttatgtagt aattgtgaaa 103680

ctagagtaac tggtaaacaa aaaacaacta ttaaatcagg ttatcatact tttaaatgta 103740

aaaactgtaa tcatactctt gatagagatg taaacgctag tattaactta aagaactata 103800

gatactccaa ttggtatcga aataatatta ttgagaaata acagtagtaa tattatatgt 103860

accgttccat gaacgggagt ttaatccttt ggagtatcta gttagtagaa tattaaaagt 103920

aactaactta gttagtgaat gaagtattca aaaacagtta cagaataagg aataaaatat 103980

ataattattt ataaatttta actcatggta ctactcgagg catactacag attagagctg 104040

accaacagca atctcaacat gcgttagaaa attttaaaag ggaatggaag tctagttttt 104100

caggtataaa cggtagctgg caggttcctg ttatgatggc tgatgatgtt aagtttgtta 104160

atatgacacc aacagcaaat gatatgcaat ttgaaaaatg gctgaatttc ttaatcaata 104220

ttatttcagc tttgtatggt atagacccct ctgaaatagg attccctaat agaggagggg 104280

gagctacagg gtcaaaaggc ggttctacat tgaatgagtc agaccctgct aagaagcaac 104340

aacaatctat gaataaaggt ttacagcctc tattaagatt tatagaagaa ttaattaata 104400

gacacattat atctgaattt ggtgataagt atactttcca attcgttggg ggagatacta 104460

agtctgagtt agataagctt agtattttac aaaaagaagt acaagtatat aaaactgtaa 104520

atgaagcaag agaagaacaa ggattaaaac caatagatgg tggagatgta attcttgatt 104580

cagcattttt acaaagtaca gcacaagaaa tacaaaaaga ccaataccta gatactaaac 104640

aaaaagaaag actgcaatta cttatgagtt atacgcaacc tcaaactgag gagcctacag 104700

atgacagtaa acaagaaaca actaatcaag aagtaggaac agataatcag ttaaaaggtg 104760

atgataacgt atatagaacg caaacatcaa ataaaggaca aggaagaaaa ggtgagaaat 104820

cttccgactt tatgtagata atattagcaa cctaattaat acttaggttg ttatttttta 104880

atttggagct acatttatac tatgttatac tatatgtgta gtaatgaata atgttgatga 104940

tatacttttt gttatattat gtatgtacat ataaaataac aattaagtga ggtgtataat 105000

cactttggaa gaaatgaaat ttaatgcttt tgttcctatg gacttaaaga aatctgtaga 105060

tacggaagat gatacaaata aatattctat cgtatctggt tgggcttcca caccagctgt 105120

tgatttgcag aatgacatta taaatccaaa aggtattgat atagaatact ttaaaaaaaa 105180

tggatatatt aactacgaac atcaacaaga taatgtagta ggtataccta cagataactg 105240

ttatgttgat ttagaaaaag gtttatttat agaagctaag ctatggaaag atgatgaaaa 105300

tgttataaaa atgttagacc tagctgagaa actagaaaag tcaggtagtg gtagacgttt 105360

agggttttct atagaaggcg ctgttaagaa acgtaacata aatgacaata gaattgttga 105420

tgaacttatg attacagggg tagcattagt aaaaaaccca gctaatcctg aagctacatg 105480

ggaaagtttt gttaaatcat tccttactgg aacggaaaca acaccagaca cacaagtaga 105540

tgcaggagcc ttacgtaaag agtcgttagc aaactctatt actaatttaa cctatgtaac 105600

aaaaattaaa gatgttaaag agtataatga tatttggaat aatgtagtag aggacttaac 105660

taaatctaat aatatgggtt atgaagaatc agttattaca ttacaattag ccaaaggact 105720

atcaagaaaa gatgctgaga tagcagttat gagtattaat aaaaaaaatt tagaataggg 105780

gattatatta tatgcctacg gaattacaaa atattctaca agaatatgat aacttagaca 105840

aagaagaagt atcaaaatct gtagaagagt ctaaagaaga agtaaaagaa gataaagtag 105900

aagacactaa aacagaagaa aaagaagaaa ttaaaaatga agtagaagct acagaagagc 105960

aagtagcaga agctaaagaa gaaccacaag aacctgcaaa ggttactgaa gaagatgcta 106020

aagaagcaca tgaacaagaa gaaaatctag aagaagaagt atctaagtca gctaaggagt 106080

cgaaagaccc tgtagataaa aaagatacta aaacagaaga caaagacaac gagaaacgaa 106140

aaaataaaaa agacaaaaaa gaagaaaaag atgaagaaga ggaagaaaaa acatctaaat 106200

ctatttctga taaagatatt gtagatggtt tccgtactat cttgaaatca ttccaagaca 106260

ttaaaaaaga aaatgaacaa tatgtgacta aatcagattt agaagaagta actaaatcta 106320

ttcaagcttt aactgataaa attaattctg ctgaagaagt ttctaaatca gttgagagca 106380

aacaagaaga taaagaagaa gcagtagaaa aatccgtaac gactaataac acttcgaatg 106440

aacaagatgt agttggttat gtagctaaat cagtacaaac agaagaacaa gcagaaacta 106500

cagaagataa agaagaacaa gaagtagaag ttaaagaaga aagtagagac ttatctgtag 106560

aagaccgtga aaaattcatg agtacctata aagaaaaatc tcaaaaccca catacgaatc 106620

gttcagaagt attgaatgct tatcaagctt acttaaatat ccgcaacaat ccagagcaag 106680

caagtgaaaa agactttaat attgtaaaag aatttgctaa tctttaatta agaaacaaag 106740

ttgtgttata ttatagtgtg taaaataaaa caataaaaaa aagagcatat atgaaaggtg 106800

atatatataa atgaaccaaa atgaactttc aaaaaagcaa catgcagttg ctgatgaatt 106860

acaagaaaaa ttatcgaaat ccttccaaac tggatacggt atcactcctg aaacacaagt 106920

agatgcaggt gctttacgtc gtgaaatttt agacgaccaa atcactatgc ttacatgggg 106980

aaataatgat ttagtattct atcgtgatgt tgctcgtaga ccagctgaat caacagtaat 107040

taaatatgat gttttcttac gtcatggtaa agtaggtcat tctcgttttg tacgtgaaat 107100

cggagtagcg tcagtttcag accctaacat tcgtcaaaag accgttacaa tgaaatatat 107160

ctctgatact aaaaatatgt cattggcatc tagtttagta aataacattg ctgaccctgg 107220

tcaaatctta actgaagatg ctatctcagt tgttgctaaa acaattgaat gggcttcatt 107280

ctatggtgat gcttcattaa cttctgaggt tggtggagaa ggtttagagt tcgatggatt 107340

agctaaatta attgatgctg ataacgttat cgacgctaaa ggtgctcact tagatgagaa 107400

attattaaac ttagcttcag ttaaaatcgg taaaggtttt ggtacagcta cagatgctta 107460

tatgcctatc ggtgtacatt ctgactttgt tactaatatt ttaggtcgac aaatgcaatt 107520

aatgcaagac aatagtggta atgtaaatac tggtttcagt gttaacggat tctattcatc 107580

tcgtggattc attagattac atggttctac tgtaatggaa aatgaattaa tcctagatga 107640

gactttaatc ccacaaccaa acgcaccaca accagctaca gtaaaagctg aagtaaaaac 107700

agaccaaaaa ggtaaattta ctaaagaaga agaccgtgca ggtttatctt ataaagtagt 107760

tgttcactct gatgaagctg aatcagcacc atcagaagca caagttgcta cagtaacaaa 107820

tgctacagat ggagtagaat taaaaattac tgttaactct atgtaccaac aaagcccaca 107880

attcgtatct atttaccgtc aaggtaaaga aacaggtatg tactacttaa ttaaacgtgt 107940

agcacttaaa gatgcacaag aagatggttc tttagtattc gttgataaaa acgaaacatt 108000

acctgaaaca gcagacgtat tcgttggtga aatgtcacca caagtattac acttgttcga 108060

gttattacca atgatgaaat taccattagc tcaaattaat gctagtatta catttgcagt 108120

attatggtat ggtgctttag cgttacgtgc tcctaaaaaa tgggctcgta ttaaaaacgt 108180

aagttacctt gcattaaaat agtaaataca attaaaaatt gaatacaata gaataaggag 108240

tatacctaag ggttgctcct tttttattac tacttatagt atacaagaaa ggaatttaaa 108300

aatcaatgtt aacttataaa ttaaaaaata ttaaaatggc tactgtacat ggtcaagtag 108360

aagtagatga taaaggcgta gttaaaggac taactgctaa acaagaaaaa gattttgcta 108420

atttaccagg ttttacacat atggaagaca agaaaacaac aaagaaagaa gtaaagccta 108480

aggaagaaaa agaagagaag aaaccaacta aaaaaacaac taaaaaagaa gataagtagg 108540

ttgataaaat ggtaaacagt atgtttggtg gtagtttaga cccttacgaa agctctttat 108600

catatgagta tccttatcac ccatctggaa acccaaaaca tatagataaa agagaattag 108660

atagtattac tctagctgat tatggttggt cagcagatgc tgtgaaagcc tatatgtttg 108720

gtataacagt acaaaacccc gatacaggac aacctatggg tgatgatttt tataatcata 108780

tattagaaag agctataggt aaagcggaaa gagctttaga tatatctatt ttacctgact 108840

tacaacatga aatgagagat tactacgaaa cagaatttaa tagttatatg tttgtacacg 108900

catataaaaa acctatatta caggtagaaa atttacaact acaatttaat ggtagaccta 108960

tgtatgatta tccagctaac tggtggaaag tggagcattt agcaggtcac gtacagttat 109020

tccctacagc tttaatgcag acgggtcaat ctatgtctta cgatgctgta ttcagtggat 109080

atcctcaatt agcaggaatg tacccaccaa gtggagcaac ttttgcacct caaatgatta 109140

cattagatta tattagtggt atgttaccta gacaaagagc aggtagaact aaaccatggg 109200

aagtaccacc agaattagag caattagtta ttaaatatgc actaaaagaa atttaccaaa 109260

tatggggtta cgatgatatt accctgtgtg tagcgtaagt tgcacatttt caaaggttaa 109320

ctgctaagaa atcctaaagc taactaaact acaaagtaat ctgaaaggat aggcttgaat 109380

gttgagaaat cagaaaaaat tagttagata ctctaaggtt aaatcctaaa gagaagagca 109440

atggaagttt agcatcgaaa gtcctaagtc aatagataag gaatacgttc aacgactatt 109500

ctgtatagac gacagaagta aagctccaag tgattgggag aagaaaaatc tttaccctag 109560

tcttagggat aacaaatagt ctgcacacgt cttgaaaagg agtgctagga attgacctag 109620

acttatttag tagcgtaagt aaggaaacaa tgttaattaa atgaaaactt cttattgaaa 109680

ttaccccaag tatatgttat attatagata taatatataa ggtggtgaaa gtaaatgaaa 109740

aaaacggaaa ataaatttta tagaggtata acactaaaag taaaccctac ccaagaacaa 109800

gaagagttaa tgtggaaaca tgtaaaccat tctagattta tttataatta tatgttagaa 109860

agatattgga aagctctcga taacggtaaa tatatagacc ataaaaatat gatttctata 109920

ttaaaagaaa taaagaatga tgataagtat agtttcttaa atgaagtatc tagaaaaact 109980

ttagttggta aaatagatga cttaagagaa acattaataa aatatcataa tcatgaaatt 110040

agaaaaccta aatttaagtc taagaaaagg gaacctaaga ggtttcctat tagatatgac 110100

cgaatgcact ttaacaaaga aaaacatgtt aaagttgaaa aattaggtta cttaagaatt 110160

tctaatggta catataaaaa taataaatca gtactagaga atgaaagcat taaaccttta 110220

aaccctaaat gttactatga tggtaaatat tggtatatat ctttttcaat tgaagtagat 110280

aatcaataca agaaagaaaa ggataatact aacgaagtca taggtataga cttaggtagt 110340

ggtaaaaaac acgtaatttg ttctaacaga aaaatatatg gtaatattat ttattccaag 110400

aaaatgaaaa ggttagaaaa aaaattatct gacctacaga aaagattaag taataaatat 110460

gatattaatc acaccaaaac aaataatgtt ttaaagctag aaaataagat agctaaagtt 110520

tatagaaaaa tgtcaaatat ccgtaaaaat catgtacatg aaataacaaa agaaattgtt 110580

gaaaagtatc ctaaagagat tattgtagag gatataagag ttcgtgattt aataaaagac 110640

aaaggatata caggacaaaa aagaaaacaa atacagtttt ctaatttcta tatgattaga 110700

cagcaattac aatataaatg tgaagataga ggtataaaat ttacagtagc tagtacttat 110760

tatccatcat cacaaatatg cagtaattgc ggagaaagaa aaagaaatgc tttaaaatta 110820

cagttaggtg ataaagtctt taaatgtaat gcttgtggat atgaagaaga tagggatata 110880

aatgcaagta ttaatttaaa aaattaccat aattcccaat ggttaaaaga acaaaaccaa 110940

taatatgttt gcttttagta gggttccata acccgaatgt ataatgcctt ttattttaca 111000

aaggaagtta atttaattaa catatggtaa tctcattatc ggtgcaggaa tagcaaacaa 111060

aactctagat gtagatggta ttacagaaac aataggtact acacaatctg ctatgtatgg 111120

tggagcaagt gctcaaatac tacaaattaa tgaagatata aaagagctat tagctgggtt 111180

aaaatcttac tttggctcca atatgatagg catatagtag gaaggagata ttaaatgcaa 111240

aaacctttta tgataggtac taataataat acttctaata taattaataa gtctactatg 111300

tatacatcta caacacaagc agatgaacaa gaacaaaagt tatctacagc tagactagag 111360

tttgacacta aggatatgag aagatttgtc aatgatagag gtataaaggt actgtgggaa 111420

agggcttact tttgtccttg ccttaaccct gacacaggac atcctagagt agattgtcct 111480

aggtgtcacg gtaaaggtat tgcctattta cctcctaaag agacaataat ggctatccaa 111540

tctcaagaaa aaggaactaa caatttagat ataggaattt tagatactgg tacagctata 111600

ggaactacac aattagaaaa acgagtatct tatagagata ggtttactgt tcctgaagta 111660

ttgatgccac aacaacttat ataccatgtt actaaagagc gtatacaaaa aggtatacct 111720

ctatactatg atgtcaaaga agtaaccttt attacatcta acgatggtaa tgtttatgaa 111780

gatgactata atatagagaa caatagatta ttcatggacg ctaagtttga aaacaaaact 111840

atatccttaa atattttaat ggtacttaga tatgtagtat cagatatatt aaaagaaagt 111900

cgataccaat atactaaatt taatcaacct aatacaaagt ttgaaaattt acctcagaag 111960

ctattattaa aaagggaaga cgttattgta ctacctgagc catttaaagt taatgatggt 112020

atagaagagg acttagagat acaggtagaa gaccctaaaa aagaatctaa agataatcat 112080

tcaggtggtt tctttggagg aatgctataa tgcctataaa agcaactaga cctaagttat 112140

ttagagacaa gaactataaa aatataggta agagaacagt agatgctatg cgttctgata 112200

ttttagatag attacaagct acagcattac aagtagataa tgtaagtgtc aaacgcatgc 112260

ctacttatct acaaataact gagaaaaagc tagagaagaa aggtgtaata gaccttaaga 112320

aagcttttgc tcattcatct aaaaagaaaa ggactaaaga tggtggttgg tatctaacgg 112380

tgcctataag aataaaaaca agtaagatga ataataaaac ataccaagac ttaaggtctt 112440

taaaaataga cagttcaagt aattcagtat ctactcttac tgattatcta gaaggtagac 112500

gaagtaatat tagtcaccca tcactaaagc ctgctagtaa atcaagtaga attactaaag 112560

taagaaatgg taaaaaatct agttacttta tgtttagaac agtatctagt aaatcccctg 112620

caagttcatg gatattaaat agagataagg ttaatgaaaa caacttctct aaaacaacat 112680

taaagtatgt tagaaatctg atgaactgga agattaagaa tttaatgtag aaaggttatg 112740

gaagtaggat ggcaataaca tcagtagact catatttatt agagcaaata aagcccagat 112800

tacatacagt actaagtaat tgttatatta tagatgaagt tttaaaagac tttgattatc 112860

aaactaggga aatgttcaaa gaggcttttt gcggtaagaa cgcaaagcac gaagtaacag 112920

tagggttcaa tttccctagc tttaaaaaca actacgaagc tcattaccta atacaactag 112980

gacaaggtca agaggttaaa aactctttag gtagtataca agggtcttat ctagaagctt 113040

cgggtaacac atatagtgaa caatcagtag ctaaaagaga aggtaatcgt ttagtatttc 113100

atgtatctaa acctatttct aatgtaataa gagtagaaga catagcgttt gattcttacg 113160

atgatgttaa agtatcagat aacactgtat cttttaatta tactaacaat gagacttatg 113220

aaggctacaa cgcaaatatt gtatatgtag aaaaaacaaa tgatagtaaa gggttagtaa 113280

aaggtattac catagaagaa caagtaacaa ttgtaggtat gtcgtataat gtagatgttg 113340

ctagatgttt agatgccgta ttaaaaatga tattgatatc tatgagagac agtatagaag 113400

aacaacaaac attccagcta caaaatcttg catttggaga tatcgcacct atattccaag 113460

acggtgagtc atctatcttt ggtagaccta ctataattaa atacacaagt tcattagatt 113520

tagattatac aataacacaa gatattaata agattacttt caagaataaa ggagcaaaaa 113580

gataatggct aagaaaacac ctaaaggtaa aacctttaca ggttatgtac atatagatac 113640

atttttaaaa acagcacaga ccttgtttaa tatgaaagag tcacaggtag caggttttaa 113700

agcctacatg gaaggtaaac actacttgtt caatgaaaaa gactttattc catttttaga 113760

aaagtattta ggtagagaat tagaaattta atatatagat aggagaatta tacatggcag 113820

ttgaaccgtt tccacgaaga cctgtcactc gtccacatgc agtcattaat gtagacagta 113880

caggtatcgg taaatcagct agctccagtg aaaagatttt atgtttaatt ggacaagctg 113940

aaggtggtaa acctgatacc gtatatgaat taagaaacta cgcacaagct aaaagactat 114000

tccgctcagg tgaattactt gatgcaattg aattagcttg gggttctaat ccacaataca 114060

cagcaggtaa gatttttgct atgcgtgtag aggatgctaa accagctaca gctgaagtag 114120

gcggattgaa agttacttca cagatttatg gtaacgtagc taacaacatt caagtaggat 114180

tagaaaaaaa tacaatcagt aattcattac gtttacattt aatcttccaa gatgatagat 114240

ttaatgaaac atatgataat attggtaata tcttcactat caaatataaa ggtagtgaaa 114300

gtacagctac tttttctgta gagcacgata aagagacaca aaaagcaaaa agattagtat 114360

taaaagctaa tagcacagaa gttaagtctt atgacttaac aggaggagct tacgctacta 114420

ctaatgccat cattaacgat attaaccaat tacctgattt tgaagctaag ttatcacctt 114480

ttggagataa gaacttagag tcttacttat tagaccctat gacagatgtt aacattaagg 114540

ataaagctga gtatgtaaaa gcagtatttg gtgatttaga gaaacaaaca gcctataacg 114600

gacttgtttc atttgaacga ttagtatctg aacaagcacc taaaaacgta gaagtagacg 114660

cacatgaaga atctgctact gtaacagctg tgtccccaat tcaagaaatc acaccttttg 114720

aattaacaaa actttcaggt ggtacaaatg gtgaacctcc tgctacatgg gcggataaaa 114780

tcgaaaaatt tgcacatgaa ggtggatact acatggtacc actatcctct aaacaatctg 114840

ttcatgcaga agtagcttct tttgttaaag aacgttctga tgcaggtgaa cctatgcgtg 114900

ctattctagg tggaggattt aatgaaacga aagaacaatt atttggtcgt caatcatcat 114960

tatctagccc acgagttgct ttagtagcta actcaggtat attcacaatg gacaatggtc 115020

gtaagttaca tgtaccagct tatatggtag cttctgctat cggaggtttg gtaagtggtt 115080

tagctatagg tgagtctatt acctttaagc aactacgtat taataatgta gaccaattat 115140

atgaatcatt agacttagat gagttaaatg aaaacggtat tatcaccgta caatatgttc 115200

gtaatagagc taatacattc tttagattaa cagacgatgt tacgacattt aatgataaaa 115260

atgaccctgt taagtcagaa atggctgttg gggaagcaaa tgacttctta tgttctgagt 115320

taaaacttga gcttgaaaat aactttattg gtactcgtac tatcaataca agtgcttcaa 115380

ttatcaaaga ctttgtacag tcattcttag gacgcaagaa acgagataac gaaattcaag 115440

acttcccacc tgaagacgta caagttattg tcgagggtaa tgaagctaga atctcaatgg 115500

ttgtataccc tatcagaagc ttcaagaaaa tttctgttag cttggtatac caacaacaaa 115560

cattaagagc ctaaactagg acaaggagta cctagtttag gtactcctat taaatttaat 115620

aggagagtga attaatatgg cttcagaggc taagcagtct gtccatactg gtaataccgt 115680

tatgctaatg gtaaaaggta aaccagttgg aagagcacaa tctgctaaag gtcaacgtga 115740

atacggaact actggtgtat acgaaattgg tagtattatg ccacaagagc atgtttactt 115800

aaaatatgct ggtacaatta cactagaacg tttacgtatg aaaaaagaaa acttcgcaga 115860

tttaggatat gcttcacttg gtgaagaaat tcttaagaaa gatattattg atatcttagt 115920

agtagataac ttaacgaaac aagttattat tagttaccat ggtttaacta aatagacccc 115980

ttgtacagtg atgtgcattg aataatacct taaattgcta gaacaccgta aagctaacta 116040

aactacaaag taagtcgaaa gactaagctt gaatgttgag aaatcagaaa aaattagtta 116100

gatggtataa ggttaaatcc taagtactac ataattggta attagcatcc aagctcctgt 116160

aaaatggaga aggttcaacg actataatag gtaagtctta gttacatatt aagattatgg 116220

tatagtctag tccctttaaa atatatcgaa aggtagggta taaacggttc cgcaaataat 116280

tacaacgaga gttggaatac taatgaaatt gttactgagg aaattgagta gaagaatgct 116340

cctttaacta gaaatagtta tagcaaatcc ctttaattca tgggaactcc taacaagtaa 116400

agttgagggc aatcatgagc caagctctta ttattaagag aaggtgcaac gactattccg 116460

aaaggaagta cactcaagtg agtggaaacg ggggacacct tcaatattaa ggtgatgata 116520

tagtctgaac tatatagaaa tatatagaag gttcaagagt agcgttttga atcgtaacaa 116580

atttgtttct tacttaacag catcagataa agctagaact taattttttt atatatttat 116640

tatattaaga ccaacttaag tgttggtctt tttatttgac atatagctaa cgatatggta 116700

acattagtat atactttaat agaaaggaat gtttttatgg gtattaaaga attagcaaaa 116760

gaaaaaggta tagaaatata tgattatgaa aaagaaccac agggtaaaaa atatcgaggt 116820

attgtattag aaggtaaatt taagaattgt gagtgtgcca tatcttatga taatttaaaa 116880

aaattaaaga aattaaggat agtacatctt acagataatg gtaaaaagca atattactca 116940

agttatgcta gaagtagagg ttatgaaatt atagattatc ctgaagattt aaaagcaaca 117000

aaacgatgtt tattactatc ccctaaaggg aataaatggg atgttatatg gaatagtttt 117060

gagaataatg aaaataacaa ttgcccacaa gaccatatga aaagtatagg agaaagaata 117120

atacagacaa tacttaaaga aaataatatt gaatttgttt gtgaaaaatc tgtttataca 117180

ggattaaata gacctcaaag attagatttt tattttgaaa tagacgggat agagtacgca 117240

atagaatata tgggtgaaca gcatataaaa caagctacag gagcatggag taaacctttg 117300

ttagagatac aaaaattaga tgaaagaaag aaaagatact gtgaagataa taatattaaa 117360

cttttatgta tttattaccc taatgaagat aaaaaagaaa ttttaaattt aataagttca 117420

tttataggta ttagattaga ctacactaaa ggtgtagaat tgtttataaa atttaaagat 117480

aatgaaaaag aaataataga cttttataaa gcacattctg caaaagaaac agcagataaa 117540

tttaacatga gtataggcaa cgttaaaggt ttaatgaaac gtagaggtat taaaaagaga 117600

tttaaacctg tgataggtct aaatattaaa actttggaag aaattaaatt tgacacatta 117660

aaagaagcac aagaatactt tagtagttta ggattacctt catcaagtat tagaggttgt 117720

gtagtaggaa gtaaaaaaca atcttgtggc tatctttgga gatatgaaga tgaagacttt 117780

tcagaagtag ccaaaacaat aacagataaa agaattaaag tatttgtagc aactaaaggt 117840

tcagaagtta ttaagttacc tttacacatg atgacaaaaa gaataaacgt agatgtatct 117900

tctattactg actgtgctaa aggaaataga aaaactgcta aaggatatat aataagagaa 117960

gcattagata aagaaaaaga agatatttta aaaggaataa gttttataga ttatatacaa 118020

aactacaaat aacactggat taacatcaag gtttatggta ctataaacaa acaggagggt 118080

gtgttaaatg acaaatagaa aaacaatagg taagatgagt aatacaaggg caacatggaa 118140

aattaaacca acaacaagaa ttaaaaaaga taaaacaaaa tattctagaa aaaataagca 118200

taaaggtatt gacaattata aataactgta gtactatagt tatataagga gatgatgaac 118260

tgtgaaaact ttttattcag gtaggagaac aacaggtaaa aacaggcaag taaagaagca 118320

ttataaacaa atgactaatc gagaaataat tatatgtagg aacttactaa aagaggctta 118380

taataaaaat aactacttta agttaacaaa tcacttcaaa ggtaaatgta agaaaccagt 118440

aaattttaaa gcgtttgttc attatataca taataagaac ttagatatta tagaatataa 118500

tgaaacatta tacaataaca aaatacaacg tagggtagtt gttagacatc cttatgtagt 118560

aaaagtagat aataaattat cttaccaata cttagttata gaagttgaaa caggtgaagt 118620

tgtaactatg tattataaca gagttacaga caaccacaga acattaaatt taaatgacta 118680

ttatgataaa aatttaaaaa taaagtattg acataagtaa atacataata tatactaagg 118740

ttacattaat aaagaggaga ataaaaaatg acaaataaat taagagctat ccatgaagaa 118800

atgaaaattg agttacataa attcccacag aatgtagatt taacaagtaa gacaactgct 118860

attgcaatca atcaaattct tgacaagttt aaaaccttaa cggaacaagc aggtaaaatc 118920

actaaaaagt attttgaggg tcaagagatt ttgacgattg attttgaata ttatgactca 118980

cttcaagatt actatattta cttacttaaa aatagtgaaa caatcgaaca aagattacaa 119040

gaaattgaaa aaagagtagc tgaatatgtt aagtaatttg gagttataac cacattatgt 119100

tatactgtat gtgtataaaa aacataagtt agctgttata ttaattatga gaaaataata 119160

aaggatggat aaagaattgg aaaaagaaca aaaagatatt aaagatatga cacctgaaga 119220

aattgatgag ttaaaatatc agcaacgaaa agataaagag cgtgttatta acaaagtaat 119280

taaaggtgtt aatgatgtat gggagaaaga atacaacttt gaagaattag atttaaaatt 119340

caaagtaaaa attagattac ctaatgctag agaacaaggt aatatcatgg ctttacgttc 119400

tgcatactta ggtggaatgg atgcttacca atctgaccaa gttattaatg cttatcagat 119460

gttagctact ttacaagaag taggggtaga agtacctaaa gaatttagag accctgagga 119520

gatttataat ctaactccgc ttgctattat gtgggatgat tggttagact ttatgacgtc 119580

ctttcgttac tagtaacgta aagcagttaa atgaagatat agaacggtta ggtggaattt 119640

cacatatagc taaagagcct ctatcaagaa acctatgggc tattatgcgt gagtttaatg 119700

tattacctac tgaacaacgt tttaaagatt tagatgatta ccaaatagag tttattatag 119760

ctaacatgaa tcttgataca aaagaaatga tggaagctag agacggtaaa aactatgata 119820

tgaaagcgga agacgtagac acatcatggt tcgaagcgcc gacagatgaa tttgatgttg 119880

ttcctgattt cttagactta gatgatttaa atacacaagt agataaaagt ttaagtgaga 119940

aagaaaagat agaaagagat agacgagttg aagctgagtt agaagatgaa actgaaggat 120000

taacaactca acatttggct atgatggaac acataagaca aaaacaaaaa gagcttgatg 120060

aaagtttagg tattgacagt aaagaaataa cacaagaaga tataaacaaa gcaataaaaa 120120

atgtagatga ttggtacatg tagggtaatg gtataatacc aataccctta tttttgatta 120180

ggtggtgaat actgtttggc aatgaatgac gattataggt tggtcttgac cggtgatagt 120240

tctagtttag aacaaagttt aaaagctata gagatgtata tggatgcgtt agagtctaag 120300

aacatagatg caccattaac aaacttctta gagaaattaa aagtaatagc aaaagaagta 120360

aaatctgtac aaaacatcat ggataaacaa agtgataagt ctctaatatc accaaaagct 120420

atggatgagg ctattagttc tacacagaat gtaactaaga atataaacga cctaaagaaa 120480

gctttaaatg acatacaaac agataatatt acaaagggta tagctcctga ccctgaagta 120540

gagaaagtat acagtaaact taataagaca ctaaacaata cacaaacaga actagagaaa 120600

gtagcatctc aaaagattgg ttcagactca gatgtaacaa acagaataaa agaaatgaaa 120660

acactgaacc aagttacaga agagtataat aaattagtaa aagatgccag ttcagctaag 120720

gagtacacaa agcaactaag agctaatcgt aatatggtta ggggtcatat atctaggtct 120780

gaaggctcta atagaatgtc ctatgaccaa ggtgctagag tacgttctga attaggtaaa 120840

gtagacactt ttgaaaagca acgagaagct aataatagaa gaataaaaga aaaccaagat 120900

agatatagag gttatagaca gcaacaacaa gatttagtag gtaaaagagc tcgtggtgaa 120960

atcagttctg aagactataa aaaacaatca gcatctatta aaatgatgat tgatgaaagt 121020

gaaaagcttt ctgaagtcta tagaaaaaca ggtgctgaat tagacaagtc aatcaactac 121080

tataaaaata gtgctaaaaa acagtttgct cagcgtgaga tagaacagca aagaggaaca 121140

atgggtaaat tgtttcaaga taggttacct tctattggtg cacatgctac tatggcagta 121200

actgctcttg caggcggtat gtatatgcgt ggggcttccc tatctgaagc aaatagacct 121260

atggtaacat cattaggaca gaattcagat aatatggaca tagatgcagt aagaaatact 121320

tatggtgatt tatccataga taataagctt ggttacaatt caactgacgt gttaaaaatg 121380

gctacatcat atgaaagttc tataggtcat aaaagtgatg cagatacata caaaggagct 121440

aaacagttag ctgtaggtgg acgctcatta ggtatacaag accaagaaat gtaccaacag 121500

tctatgtcac aacttatgca tacaggtggc gtaaattcag ataatatgaa agctatgcaa 121560

gatgctttct taggtggtat acgtgaatct gatatggttg gtagacaaga tgagcaatta 121620

aaagctttaa gtactattgc cgagcagtca ggacaaggta gaacattatc taaaggagac 121680

atgtctaatc ttacttcttt acaagctcaa gtagcgggta caggtagtaa aggtttacaa 121740

ggagctcaag gggctcaagc gttaagtagt attgaccaag gtattaaaaa tggcatgggc 121800

aattcttaca ctagactagc aatgggatgg ggtactaagt accaaggatt agaaggtatg 121860

catgacttac aagcacaaat ggataaaggt atatcagacc ctaataactt agttaatata 121920

tttgaccaag ctaataatat aggaagtaca acaaaagaaa aacaagccat agctaaaaaa 121980

ggctttgaaa gcatgggagc taatttaaca caagagcaaa cagatgagtt gtataatctt 122040

tacgcctcag gtaaactatc taaagaagag ttagctagta aagctaaaaa gatggagcaa 122100

gaaggttcca aagcaggaga taagaatagg tataagtatt ccgaatctaa agcaggtagg 122160

aatgaccaga acaaagctaa gacagatgat aaagccgagg atatttatga cttagctcaa 122220

cctattagag atgttcatag tgctatggca agcttgccag ctcctttata cctagcttca 122280

ggagcagtac ttgcatttgt agcatcttta gctaaatcta ctgccatgat ggctggtggt 122340

tctttattag gtaaaggtca aaaaggatta aaagattggt ttaataaccg taaaggaggt 122400

tcaacaggta agactggtgg tggtaaacct ggtggtaatc ctaacggtgg tggacgcttt 122460

ggaggactta aaaacttagc tgacactata ctaggtgata accctagagg tggagaccga 122520

ccatttaaag accaagcaaa aggagcagga caaactgcta aaggcatggg taaaacctta 122580

tttgatacct ttggaaaaag agattttact tttggtgaat atatgggaag aaccaaagac 122640

ctaggtaaag gtgcatggaa caaaggtaaa ggagcttttg gtaaagctaa aggtaaattt 122700

agtggtaaag gttctaactt aggttttatg tcacaagcac ctactgctaa cgcaggtggt 122760

cttggtaaac taggtggtct tacaagtaag ctaggttgga ttggtgcagg tctatcggcg 122820

tttgatatag gtagttcttt aatacaagga gatactaaag aagcttcttc taaatttggt 122880

aacactatag gaagtgtcat agacccatta aacctaggtt atggggatgg attaagagac 122940

tatgctacga aaacagcaga aggtgcttcg acaggtgatg gttggaaatt atgggctaat 123000

ggagataaag atggtaagaa taaattccaa gactcacctg taggtaaact atggggtggt 123060

ataacagatt tcttcacacc agatgaccct tctaaattag atgaaacagt gaaaaataaa 123120

aaaggtaaca taattagtta tatactaatt gccttgctta tagagcaatc tgtaagtacc 123180

gagtgttaac tgctatgaaa ctactaaagc taactaaact acaaagtaag tcgaaagact 123240

aagcttgaat gttgagaaat cagaaaaaat tagttagata ctctaaggtt aaatcctaag 123300

gagaagtaca atgggtgtat agcatcgaaa gtcctaaaga cctgaaaggt ctacggaaca 123360

cgttcaacga ctattccgta taggtgacgg aagtaaagcc acaagtgatt ggtggaagaa 123420

aaatactcac cctatactaa tagggataac aaatagtctg cgcacgtacc gaaaggtagt 123480

gtctagaaat aactagagaa tatacagtag cgtgtatatt taaacattgt taaaatatat 123540

aaataattaa aatttgtatt ctacttctgc atataaacct ttcttatttt gtaaggtaaa 123600

cttgttatta aataaatata cataactaat acgataggtt atatatgaaa gtatactatt 123660

gtttatatgt tttaacttat ggtattaatg ataaatcaca aagtaaagac aggcaaaaag 123720

cagaagaaaa aagagaaaag aataatgatt ctagagaagg aaatgtaaca gtatactcac 123780

atttcttaga ccatttagca gataacctaa caaataaagg tagtagttct aacgacagtt 123840

catcaggagg aacacttgac taccttgatg gtaaaaactt tacggataaa gacgtaacta 123900

agcatgacct aggtaaaact gctaaaggtg taaacgccga aatgttaaat aaatggattg 123960

agtctcaagc acctagtaat tctaaaatgc gtggtttagg tgagctttat atgaaagcag 124020

gtaaagagtc aggacttgac ccaaggtatt tagtagcaca tagtgctgtt gagacaggct 124080

ggggaacatc aaatctttcc aaaggcggag accctaacaa aggtaactgg ttcggtatag 124140

gtgcttttga taacaatcct aataatggtt ttaactatgg tttgggtatt gttggtggtg 124200

ctaaatggat tagagacaac ttctacaaca aaggacaaaa gaacttacac gatatgagac 124260

acaacaatgg tgttcatgaa tatgcaacag caggtaattg ggatactatg attgccagta 124320

ttatgaaagg ttcagacaag ttcataggtg gcggaggtgg aggcagtgat gttatgccta 124380

gatatgctct aaaaaacgac catcaaccaa agaatcttaa atataacata gaagtaccta 124440

aaagtaaaaa ccctaatgaa acagggaaag caataggtag aaaattaaaa caattattag 124500

aatctaattt ttagaataca attataatac ttatatactt taacaaatgg tacaaataat 124560

aaaaaacaga aaatgtctac agaacaacta agagaaaaga ataataaatc agaaactaaa 124620

aacttaaaaa cttacagtaa cctattagat agagcacaac aaattataga agatgctaaa 124680

gcgctagact caggaggttc agacagtagt tctgactcag ggggttcagc ttccgatgta 124740

gatggagaag gtgcgggtaa gatttacaaa ttccttaaag gtaaaggttt atccgataac 124800

caagtaggtg ccgttatggg taaccttaag caagaatcag ggcttgaccc taatgcaaag 124860

aacgcctcta gtggtgcttt tggcattgca caatggttag gtagtaggaa atcagacctt 124920

gatagctttg ctaaatctaa aggtaaaaag tctaatgact tagacgcaca attagatttc 124980

ttatggaaag aaatgagttc gggtcaaaac agtgatatgc ttaaaaatgc aggatggagt 125040

aaaagtggaa gcttagaaaa aaatacaaaa gcttttgcac aaggttttga gcgtatgggt 125100

gctggagaag ctatgatgag taccagagtt aacaatgcca aaagctatgt tagtaaatac 125160

ggtaagtcag gtggtggcgg tggcggagtt ataccatcgt catatacttc agtcatgaga 125220

aatcctatac ttagtagtac atctggaagt agtaaatctc aaaacaatgt gtctgtgagt 125280

gttaacatca caggagtaaa cgataaagaa gatgcggaag gcataagcaa aggtattaag 125340

tctacctttg gtgacgattt agacatcttc tcaaacacgt ataaacgtaa ttattagggt 125400

agtattatta agtactaccc tttatataaa aataaaggaa gtacatatat gtatagaatt 125460

agacgaccta agataagaat agagatagta acagatgaca atacatttac attaaggttt 125520

gaagatacta aagattacac aggaaatcag tttgcttcaa aattaataaa cttccaaact 125580

aaaaatgcaa tggaagatga cagtgcagta ttccaaataa caatggcagg ggatacatac 125640

tgggataagt tagtaatggc aaatgatatt gttaagatat atattacacc taacaatgac 125700

cctaaagata aggaaggaaa taaagagaaa cttatacaag taggtatggt atctcaagtt 125760

tctaaagtag gaagctatag taatgaccag gttcagttta gaataacagg tcaatctttt 125820

gtaaaacctt ttatgaaatt tggtttaggt gttatacaag aagtacaagc tgtattacca 125880

actgttggtt ggttagttga tggtgatgga gagaaccaag ttaagtttac aggtagttca 125940

gctaaagatg taatgcaagg tattatacaa cgatttatcc catacatgaa atataattat 126000

acagataaaa cgtataacac actagagagt tatttagatt atgatgattt atctagttgg 126060

gatgagtacg aaaagttaac tgaagtttcc gcttttacta acttcgatgg tacattaaaa 126120

cagctaatgg acttagtaac tgctagacct tttaatgagt tattttttag aaattcagat 126180

aaacataaag gtaaagcaca gctagtatta agaaaaactc cttttaatcc aactgaatgg 126240

aaagcattag aatatatagt tgtacctacg gaagatttta tagaagaaga tgttggtaag 126300

agtgacgtag aaacatactc tatatttaca gtaaaaccag caggtatgtt aaaagaatta 126360

acaggggatg tattctctaa acctcaattc catcaagaat tagtagatag atatgggtat 126420

tctaaatatg aaacagaaaa cctatacata ggaactaaga gtggtagtga tacagaagat 126480

agtgaaacta caggtggaga taacggtcat gaacgagtaa cttatgacag actacttaaa 126540

gatttaaata actatggtag agagtctata tctaaaggat tagataaata ctctagtaag 126600

atatcatcaa aatacaacaa tattactaaa cctgaagtaa agagtatttt agaatcttat 126660

ataaaaaaag gtaatctaag taaggaagaa tatgaaaaaa taacaaagaa caatacttca 126720

agagagtcag tatctgatac tagaccaaaa ctaacaaaag aaaaattaaa gtctatatta 126780

gcggaaaagt ttaataagaa agaaactttt gatgataaag atttaaataa gaaaacaaca 126840

aaagctgtaa tagatgatat tacaaagaat tataagtatg gtaatcctac acatgctaag 126900

aaactactag aggattacac tagatttaaa ggtaacccac ctacaagtac cacaggtgat 126960

atttatgata agtatcttaa agccgtagaa ggagtagcta atgttgctat agatacaggt 127020

tctgacgcaa gtgatgaccc tttaattata tttactaaaa tgctatttaa ttggtatcac 127080

tcaaacccta atttttatgc aggtaatatt gttgtattag gtgaccctaa gtatgaccta 127140

ggtaaacggt tatttataaa agataaacaa cgaggggata tatgggagtt ttacatagag 127200

tccgtagaac ataagtttga ttataaacaa ggatacttta ctacaatagg agtaacaaga 127260

ggactaaaag atgctattat aaaagatggt gaaggaagca aacataggtt taaaggacta 127320

tggaatcagt catctgactt tatgggtggt cttatgggtg aagagacatc taaagaatta 127380

aaagaaaaag gtgtagccga gaagaaaaca aaaggaaata aagatggaga ttctgacgga 127440

ggcgcacaag atggaggtac cttagcttca ctagaaaaat ataatggtaa gttgcctaaa 127500

catgacccca actttgttca accaggcaat aggcattata agtaccaatg tacatggtat 127560

gcctataata gacgtggtga gctaggtatt cctgtgcctt tatggggaga tgccgccgac 127620

tggattggca gtgctaaaag tgcaggttat ggtgttggaa gaactcctaa acaaggggct 127680

tgtgccatat ggcaaagagg tgctcctggg ggaagcttac aatatggaca tgtcgctttt 127740

gtagaaaaag tattagacgg tggagctagt atatttatat cagaacataa ttatgcaact 127800

cctaacggtt acggcacaag aacaatagac atgagttcag caataggtaa aggtgctcaa 127860

tttatatatg ataaaggata attgatatgg caacggataa acaagttaaa gatgttatag 127920

ataaatttat agataatctt ttcaattttg aagtattaac caaagaaaag gttgaagaaa 127980

aagataagga agttaaaaag ataactacag aagacgtata caataaagtt gtttatatta 128040

gaccatatgt aggtgttata caaagtataa cacctagaca agtaacatat gatagtttta 128100

ctaataatgg tacagatata gaagctaaac tcacacttag aaaaataagt tatactactg 128160

ataatctcac attacctact gatgcattat caacttgtat ggtacatatg gtagaaagaa 128220

atggtgtact tgttatagat tactttgatg agttacagaa catactgtat ggtagttaca 128280

tggataatga gcatatattt gatgaagatg ttccagttag tacattagta acattagact 128340

tgaaagagaa tttaagtagt tataaacata tacaatacat gtttaaaggg aatacggata 128400

aaaacccttt tgaaagtaag gatatagtac ctttagatac atacaactta ttatattgga 128460

tgtataaaaa gagaaatgta gagctaaaaa atccattaac agttaactac ttcttcacag 128520

gtaaaagctt ttatactata tttggtaaag gacacaaata taaagttgat attgacaaat 128580

tcaaaatagg tgatatacta ttctttggac gtagtgatga taatataggg atatacatag 128640

gagataagaa gtttatttct cttatgggta catttcctaa agataacacc tctattaata 128700

cctataagtt agacgattat tgggatgact ttaatggtag ggttatgagg tttgatgagg 128760

atgatatagc atggtggtaa gattacaatc ttctttaggt agaagtttaa aaaagataga 128820

ctcagaagaa cttaatgtta aaggtctatt attaggtaca gtaagcaaaa taaattataa 128880

gtaccaaact gtagaagtta aaataaatag tttaacacta ggacgtaacc ctagtgatga 128940

cggtaagtta gctgttcctt atcctaaaga ttatgtaggg agaacacctg aaggtagcat 129000

gtatggcagt aatactttaa taacggaagg aactactgta ctgttaggat ttattaatga 129060

tgacattaat taccctatta tactagctat ctatggtaat acagaagcaa accaactcat 129120

aaatacgaat cctttagagg gtggtaaaat gagtaatgat gatgtttata aatatagtag 129180

tgctttgtat tctatattac ctgacctaac ttatacatat aaagatggtg aaggtacatc 129240

tataaaaaca ttcaatggta aatctttctt atccattact tcaggtgata aagaaaaacc 129300

tttatcttca gacttttata caggtactga ataccaagac ttatttccat catactatag 129360

taacaaaaat ttaatagaac ctagaataca aaaggcacct aacatgttat ttaaacacca 129420

gggtctatac tttgatgatg gttctggaga taatcatgtt acaactttat ttatttccga 129480

aaaaggtgat gtaagagctt cagtattaga caaaagcaca caaaaaagaa caacacaaga 129540

gatgtctcac gatggttctt atagagttat aaagcaagat gatgacctat tattagactc 129600

agcgcaagta tgggtagagt ttggtataaa tgataataat gtgttttaca taaaaaaccc 129660

taagcatatg tttgaattta atgataaagg tatatattta gatgataagc caattttaga 129720

tacgttagat gctagcatta cagagtctat agatagactt aaggaagtac agaaagaatt 129780

agatgacatt aactacttac ttgaaggtgt aggtaaagaa aacttagagg agttaatcca 129840

agagactaaa aaatctatag aagtttctag taaggcaagt agcgatgtta cgactatgaa 129900

atctcaaata tctaatgtaa gtagtagagc tgagggtatt attacacagt ttcaagagtt 129960

tagagacaaa acatttaaag gcttatatga agatgcttct actatgataa ataaatacaa 130020

ccaagaaata cctgagttaa aaagtagatt gaatactcta gatacaatta cattacctaa 130080

cattaataat accttattag agaaatcaag taagacctat gttaataaca gttctcaaag 130140

tgttagtagt aattatctag gttcattact gcaattagat agtaacctta ttatttatcc 130200

atacacacct acacgtatta catggaataa gatagttttt aataattctg agtttgtaaa 130260

taagactaag gatgcttttg ttattccgtt aggtgtatct aaagttaaag tttctattaa 130320

tcttaaatgg gatatattac aagataaagt aaaaactatt acagtcaaga agaatagtaa 130380

tacatacaaa actataacta atggtaatac acacgataat ataattacaa atgttatacc 130440

tgttaaacaa ggagatacat tcacagtaga agtacaacaa gataatgata ttaaccttac 130500

attactacaa gataatacaa tgtttagtat agaagtatta gaaactactt tagcacctac 130560

taacactgag ttattaggta tagtatccga acaaacagat aagcaactac aaacacttgt 130620

aaattctaat gttgatttat tgagtttgac aacacaagtt actaaagaca atcagttagt 130680

ctgtcttaat gattctaaat tagatactat aacaacaggt aaaggtaatg tgtctgatta 130740

cactctacaa caaataaagt cattttcagc taagaatggt gagagtattt tatctttaga 130800

agatgtatta gctaaatata aaaattctat tagatatagt attaatttac caactactgc 130860

aaacatagta gaactactga aaaaatataa tttaattggt ataagagcac ctaggaatca 130920

agtgtatttg aaagttaaag atttaacaat cacacaagaa gtattaaata atttttctaa 130980

cttaccagta ttatataata cttcctatct aacaagtaca gatattaaca aaggtatata 131040

tacaaatata tacggagtac tactaccata tactagcatc actcaagata cagtaaatac 131100

agcacataat aataacctat ctatatatgc tagtggtgat atgacaagtg atattataaa 131160

taagcttatt ttatatggta tagatggtgt agaaacaaat aaaatattag agtttaaaaa 131220

agtttaaaag tcctattaat agggcttttt tatatatgtc atgttatatt aaacttgaga 131280

aagtagttgt atttaaatcc tatatatgat ataatacgat atagaaaggt ggtaagttat 131340

gcctcaatca gatggaaaga atacaataag acgtattgca ttacgttttc caacagcaag 131400

cggtaaatat aatatgtacc gtttcaaagt aaaccctgaa agttatgaaa tagatgcacc 131460

acaaagaaca tctataacta aaactaaatc agatattatt gttgaagact atggtaaaga 131520

tatagagaca ataacttttt ctggtactac tggatttaga cctgtaaaag aagtagatgg 131580

tactaaaaca ggaaaacaaa aaatagagga actacaagaa caagtagaag catacgctaa 131640

gcagggtgga gatggtagcg tagcaggagc ttatatagag ttctataact ttactgatga 131700

taaatattac aaagtacatc tagcaccgca aggtttaaaa ataacaaggt ctaaagatga 131760

atccttgtta tatagatatg aaataacttt agttgtgata ggtaaccttg ctgaagcaga 131820

tagaggttcc gtaacatctg ctgagtttgg taatgtaaaa cctaatgcta aacaaagagt 131880

tgatgagggt gttaatgatt tagatagtaa cgcacgaaaa acaagaaaca agaataatca 131940

aatagtatca caatttgaaa ataaaagtag tcaaagctct tctaattcta gtagtagcgg 132000

ttcacgatat ggaacggcag gaacattaag aggaggtagt ggcataagaa caggtggttc 132060

tgaaggtagt agagacggta tgagcaatat aggtatatat aaccctagac agaatactaa 132120

cggtcttagt agtactgttg atgatatggc acttaaaata ggatacggtg atggaggtgt 132180

atctaggtaa tgaataatta tatacctcag ccacaaggat tattaagatt tttaaatgga 132240

ttagagttag acatgtctta cacacatatg aacttattag atgaggaagt accttttgtt 132300

tctaaattct atacaccaca aatacaacta agtgaacttg caagaataaa attaaaagag 132360

attaagtcta ctgatatccc tactttagaa agaacattta acaacaatac aatagttaat 132420

aaagtagaac aaacaagttt aaagttacaa tcacctagaa tgtatttaat tatgcaatct 132480

atcgtaatgg aagcttacgc tattgtaaac tgctttgtag aaagtcctga atacttaaaa 132540

tatttaacag aaaaagatgt atctatagta agaagtaatg ttaactacgt agctgactat 132600

ttaagtgatt atgaagaata caatagtatt gttctcgatt taagagattt agacttatgt 132660

tttggctctt tggaattaca actaccacta attaagagtg aggtggtata atgagattta 132720

gaaagcatga agtccaacca gaagaaacct tacaagctat atcacaaagg tattatggtg 132780

atgttagtta ctggttagat ttaatagaac ataacaatct acaatatcct tatattgtag 132840

atacagatga agaaaagaaa aagaaccccg agcacttaat aactaaaggt gatattatta 132900

tcataccttt agatgctgag ttaacagact cggtttctaa agaaataaca tcaagagaca 132960

aagatgtatt agtagaatta gctttaggta gagacctaaa tatgacggat aataacgagt 133020

atatagacgc tcatggaaca gatgatgaaa tattagccct atcttcagat ggtagaggag 133080

accttgatat agttaaaggc atagataaca ttaagcaatc tttaagagct agactattga 133140

cacctaaagg ttctttatta ttacatcctg aatatggttc taacattcat aatttatttg 133200

gtttaaatat acctgaacaa gctacgttaa ttgaagtaga tgtattaaaa accctaacat 133260

cagatagtag agttaaatca gctaacttaa aaggttggga gataaaaggt aatgaatact 133320

atgggtcatt taatgtagaa atcaagtccg tagaagaatc tatagacttt gtattaggtc 133380

aagatgattc aggtgtcttt gctttatttg actaagaaag gaaatttata tgagaacaag 133440

aaagttaaca cagatattat ctaggttaat ggataagacg atacaaggta caagcaaaat 133500

aacagacttt acacccggtt cagctgtacg ctctctttta gaagcagtag ctttagaaat 133560

agaacagtat tatatattaa caagagaaaa cattaattgg ggcattcaag aagggattat 133620

tgaagctttt gattttcaaa aaagaaaagc taagcgttct tatggtaatg tagatattca 133680

attttaccaa cctttagaca tgagaatgta tatacctgca ggtactacat tctcatctac 133740

taggcaagaa taccctcaac aatttgaaac attagttgat tactatgctg aagaaggaac 133800

cactgaaatt acagtagaag tttactgtaa agaagttggt attgtaggta atatacctga 133860

agatatcatt aatacaatag cctcaggctc tagtttaatt cgtaaaatta caaacccgac 133920

ttcctttaat acaggaacaa aagaagaatc tcaagaggat tttaaacgta ggttccatat 133980

gtttgtagaa tcgagaggaa gagctactaa taaatctatt agatatggta cattacaagt 134040

acctgatgtt gatggtgttt atgtttatga agaagtaggt catgttactg tatatgcgca 134100

tgataaaaac ggaaatttat ctgctactct aaaaaatgac ataataacgg cattagaaga 134160

ttacagacct agtggtataa agttagatgt tgtaggcgta gagaaagagg aaatagatgt 134220

gtctgcagta gtaacaatat ctaataaagc taggataggt gatacattgc aaagacatat 134280

tgaaagtgtt attagaggat acctaaatag tctgactact tctgatgact taattattaa 134340

cgatttaatt caagctatta tgaatataga tgataattta atttatgatg taacatttaa 134400

gaatttatct acaaatatag aagtatcttc gaaaggtatt attagagcag gggatattaa 134460

ggtagaatta atataagggg gtaaacaatg gctaattttt taagaaactt acacccttta 134520

ttaagaagaa ataagaataa taaagataac caagacccta actatgcttt aataacagca 134580

cttaatgatg agatgaacaa catagagtca gacaccatta aaagcaaact tcaatcatca 134640

ttaaaaactg ccacaggaga ttacttagat aagtttgggg attggtttgg tgtatacaga 134700

agaataaatg agaatgatga cagctataga aaaagaatta taaaatactt attattaaaa 134760

agaggaacta acaacgctat tattagtgct attaaagatt acttagataa tgagaatata 134820

aatgttagtg tatatgaacc ttttaaaaat atattttata ccaataaatc aaaattaaat 134880

ggtgaagatt atttaatggg ttattattat agatttgctg tgataaatgt ttctgttgat 134940

ggttactttc ctttagagat tatagatgta ataaatgaat ttaaacccgc aggtgttaag 135000

ttatatttaa cttatgatgg tgctactacc ataaagggtg atggtgttgt taaatggctt 135060

aaaaatctac ctaaaattga aacatatacg gatttagata gattattagg ttatgatgaa 135120

actttctatg ggcatttaaa catgagtgaa gcaacagctg aacaatctga taaaacaagg 135180

ttcagaacaa ataagagtat attaaatagt gaagatattc tatcaggctc ttctaatatt 135240

ggacgtagat ttataaatta tgcttatgtt acgacatatg catatgaacc tactagtaca 135300

tcagccgtca cacatatagc ttctttaaat gataaaggaa aagaagcatc tttagattat 135360

tacttataca catccttaaa gaatactaat gatataaata tatcaatgga aactgcttat 135420

ggtgtatctt atttatacaa taactttaat gtaagtgagt ttatcagtag atacaaacct 135480

aatatagata taactagaga taatgctaaa aaacaaatat ccgattttgt aggggaacta 135540

acaattgatt tctttgcaaa agctttagtt tcacctgatg aatcattacc tattaagtta 135600

caaatatttg attttcgtac taatgaatgg ttaactgtat cagaaacaga actatctttt 135660

tacgagaaaa acataggtgt aaacataggt tatataagag attacttaaa tgatgacctt 135720

aatttattta caagattaga ggttaatata ggtaaagatg agcaaaaaga tataagtatt 135780

aactacatgg atttacattt ttataattat aaaaaagatg tgtatactat caaacctttt 135840

aaggcactag ttgaaaacta catagatttg actaaagata cttatattga aggctttaaa 135900

gtagcctcat tattaaatgg agacataatt aataaaaatg gatatcaacc cataaaatat 135960

ttaaggttac atgctactta tgattcaact aaacctattg taagtattac aggtaaaaac 136020

agcaataatg aggtacaaaa taatacacct atagatttat ataaaaatac aactaataga 136080

aacttattgc aatcatataa aggtgatagt agtatattca agggtgttgt aagcacaaaa 136140

gagttttata tctcatcatg gtctgacacc ttatataact caacgtattt atctaaagta 136200

ctagaaccgc aaaaagtata tactttgtca ttcgagatgg aaatcacaga tgctaatatg 136260

gacttaaaaa catattctga caatcatggt atatatttat atagtagtac taaaggtatt 136320

gttgctaatg gtgttaaaag catgcaaaga aagataggta acaagattga tgtatctatc 136380

acatttacag cacctacaat tacagaccat agacttgttg tttacacagg tagatataca 136440

gcagatggta ctgcctctaa aacacctatt gcttctaata cggtaaaagt aacaaacctt 136500

caactaaaag aaggagctac taagaaggac tacacggtag cacctgaaga tgtaactaat 136560

gtt 136563

<210> 3

<211> 18137

<212> DNA

<213> Podoviridae sp. BP-14

<400> 3

aaaattacac ccacccaccg tttaaaataa acgattatac aaatcaaaac ttataaattc 60

acttatcatt tctttactaa acttataaat actgtttgac aacttaacaa cttatctaac 120

ctataacata ttcatcaaat acaaaattta tgtatctatt gacttttatt caaaattatg 180

attttaacac aaaataaatt taatttactt atttaaatat tctatgatat aattagatat 240

aaaataattg gaggtgtgta ttaatgtctg agtttgaaga aattattaaa ccagaagata 300

aagaatcaac agaatcaaca gaagaatcaa cagaatcaac agaatcaaca gaatcaacag 360

aatcaacaga agaaactgaa gaatcatctg aaagtgaatc agtagaaaca attgaagaag 420

aaaatgaaaa caaattagaa cctactatta ctgatgaaga tagtgcaaaa ttagaccctg 480

ttgttttaga acaacgtatc gcttcattag aacaacgatt tactaatttt gaaacatcac 540

aaatgcaaca accacaacca caaccacaac cacaaccaga tgttactgaa gcagatgaca 600

acgacaaaga ctattcagat gaagaattag tggataagtt agatttagat taggaggaat 660

ttaaacatgt atgaaggtaa caatatgcgt tctatgatgg gtacatcata tgaagattca 720

agattaaata aacgaacaga attaaatgaa aatatgtcaa ttgatacaaa caaaagtgaa 780

gatagttatg gtgtacaaat tcattcactt tcaaaacaga catttactgg cgatgtagag 840

gaggaataat aaatcatggc agaaaagagt acaaaaaacg aaacagcact attagttgca 900

cagtcagcta aatctgcatt acaagacttt aatcatactt attcaaaatc atggacgttt 960

ggtgataagt gggataattc taatacaatg tttgaaacat ttgttaataa atttttattc 1020

cctaagatta atgaaacgtt attaatcgat attgcattag gtaaccgttt taattggtta 1080

gctaaagagc aggactttat cggtcaatac agtgaagaat atgtaattat ggatacagta 1140

cctattaaca tggacttatc taaaaatgaa gaactaatgt tgaaacgtaa ctatccacgt 1200

atggctacta agttatatgg tagtggtatt gtgaagaaac aaaaattcac attaaacaac 1260

aatgatacac gtttcaattt ccaaacatta gcagacgcaa ctaattatgc tttaggtgtc 1320

tataaaaaga aaatttctga tattaacgta ttagaagaaa aagaaatgcg tgcaatgtta 1380

gttgattact cattgaatca attatctgaa tcaaatgtac gtaaagcaac atcaaaagag 1440

gatttagcaa gtaaagtttt tgaagctatt cttaacttac aaaacaacag tgctaaatat 1500

aatgaagttc atcgtgcttc aggtggtgct atcggacaat atacaacagt ttcaaaatta 1560

aaagatattg ttattttaac gactgatagc ttaaaatctt atcttttaga tacaaagatt 1620

gcgaacactt tccaagtagc aggtattgac tttacagacc atgttattag ttttgatgac 1680

ttaggtggtg tttttaaagt cactaaagat attgtcgtat caagtgatgt atcagttaat 1740

ttcttacgtg cttacggtga ttaccaaact cataaaggtg atacaattcc agttggttca 1800

gtattcactt atgatgtatc aaatttatct gaatttaatt ctaacgttga agaaattaaa 1860

ccaaaatcag atttatacgc atttattttg gatattaatt caattaaata caaacgctat 1920

acaaagggta tgttaaaaca accattctat aatggtgaat ttgatgaagt cacacactgg 1980

attcattatt attcatttaa agccattagc ccattcttta ataaaatttt aattaccgac 2040

caagatgtaa caccaagaac agaataatag aggtgctata aatgactaaa cataataaag 2100

gcgtacaggt tgaattatct aaagaaatca ataaacgtgt cgtagaacat cgcaacagat 2160

ttaaacgtct tatgtttaat cgttatttgg aatttttacc actattaatt aactatacca 2220

atcgtgatac ggttggtata gattttattc aattagaatc tgcattaagg caaaacatta 2280

atgtagttgt tggtaaagca agaaatgaac aaatcatgat tttgggctat gttaacaaca 2340

cttattttaa tcaagcccca aatttttcat caaatttcaa ttttcaattt caaaaacgat 2400

taacaaaaga tgatatttat ttcattgtcc cagactattt aataccagat gaatgcttac 2460

agattcataa aatatatgat aactgtatga gtggtaactt tgttgtaatg caaaataaac 2520

caattcaata taatagtgat atagaaatta tagaacatta tactgatgaa ttatctgagg 2580

ttgttttatc tagattctcg ttaattatgc aagcaaaatt tagcaaaata tttaaatcag 2640

acattaatga cgagtcagtt aatcaacttg tatcggaaat atacaacggt gcaccatttg 2700

ttaaaatgtc acctatgttt aatgcagatg atgatatcat agatttaacc agtaatagtg 2760

tgattccagc actaactgag atgaaacgcg aataccaaaa caaaattagt gaattaagta 2820

actatttagg tattaattca ctagcagtgg ataaggaaag cggtgtttcg gacgaagagg 2880

caaaaagcaa ccgaggtttt actacatcaa atagtaatat ttatttaaaa ggtcgtgaac 2940

cgattacatt cttatcaaaa cgttatggtt tagatattaa accgtattac gacgatgaag 3000

ttacttcaga aatcacaatg atagatacat tgtctaatga tgaaagtagt gaatacaatg 3060

gctagatata caatgacttt atttgatttt attaaatcag aattaattaa aaaaggtttt 3120

aatgaatttg taaataatga taaattaacg ttttatgatg atgaatttca attcatgcaa 3180

aaaatgttga agtttgataa agacgtttta tccatcgtta atgaaaaagt gtttaaaggt 3240

tttaaactta aagatgactt atctgactta ctttttaaaa aatcatttac aatacacttt 3300

ttagatagag aaatcaacag acaaacagtt gaagcttttg gcatgcaagt gattactgta 3360

tgtatcacac atgaggatta tttaaacgtt gtatattcat caagcgaagt tgaaaaatat 3420

ctacaatcac aagggtttac agaacataat gaagatacaa caaacaacac tgatgaaacc 3480

tcaaatcaaa acgctacatc tttagacaat tcaactggta tgacagcaaa cagaaatgct 3540

tatgtgtcat taccacaaag cgaggttaac atagatgtag ataacacaac gttacgattt 3600

gcagataata atacaattga taacggtaaa actgtgaata aatcaagtaa cgaaagtaat 3660

caaaacgcaa aacgtaatca aaatcaaaaa ggtaatgcga aaggcacaca attttcaaaa 3720

cagtatttaa ttgataatat tgataaagta tacgatttaa gaaagaaaat tttaaatgaa 3780

tttgataaaa aatgtttttt acaaatttgg taaaggtgga aaattatggt atataatgaa 3840

aacgatttta aatattttga cgacattcgt ccatttttag acgaaatata taaaacgaga 3900

gaacgttaca caccgtttta cgatgataga gcagattata ataccaattc aaaatcatat 3960

tatgattata tttcaagatt atcaaagctc attgaagtat tagcacatcg tatttgggac 4020

tatgacggtg agttaaaaaa acgttttaga aactgggacg atttaatgaa agcattccca 4080

gaacaggcta aagacttatt tagaggttgg ctcaatgacg gtacaataga taacatcatt 4140

catgatgaat ttactaaata tagtgctggt cttacatccg catttgcatt atttaaagtt 4200

gcagaaatga aacaaatgaa tgactttaaa gcagaagtga aagacttaat caaagatatt 4260

gaccgtttcg ttaatggttt tgaattaaat gaacttgaac caaagtttgt gatgggtttt 4320

ggtggtattc gtaatgctgt taaccaatct attaatattg ataaagaaac aaaccatatg 4380

tactctacac aatcagattc acaaaaacca gagggttttt ggattaataa attaacgcct 4440

agtggtgatt taatatctag tatgcgtatt gtacaaggtg gtcacggtac tacaataggt 4500

ttagaacgtc aatccaatgg tgaaatgaaa atatggttac atcatgacgg tgtagcaaaa 4560

ctgttacaag ttgcatataa agataattat attttagatt tagaagaagc aaaaggctta 4620

acagattata caccacattc acttttaaac aaacacacgt ttacaccgtt aattgatgaa 4680

gcaaatgaca aaatcgtttt aagattcggc gacgggacaa tacaggtacg ttcaagagct 4740

gacgtaaaaa atcacattga taatgtagaa aaagaaatga cgattgacaa ttcagaaaac 4800

aatgataatc gatggatgca agggattgcc gttgacggtg atgatttata ctggttaagt 4860

ggtaacagtt cagttaattc acacgttcaa attggtaaat attcattaac aacaggtcaa 4920

aagatttatg attatccgtt taaattatca tatcaagacg gaattaattt cccacgtgat 4980

aactttaaag agcctgaggg tatttgtatt tatactaatc caaaaacaaa acgtaaatcg 5040

ttattacttg ctatgacaaa tggcggtggt ggaaaacgat tcaataattt atatggtttc 5100

ttccaacttg gagaatatga acactttgaa gcattacgtg cgagaggttc acaaaactat 5160

aaattaacaa aagacgatgg acgtgcgtta tcaattccag accatattga cgacttaaat 5220

gacttaacac aagcagggtt ctattatatt gacggtggta cagctagtaa acttaaaaat 5280

atgccaatga atggtagtaa aaaaattata gacgctggtt gtttcatcaa tgtataccct 5340

acaacacaaa cattaggtac agtacaagaa ttaacgcgtt tttctactgg tcgaaaaatg 5400

gttaaaatca tgcgtggtat gacgctcgat gtatttacat taaaatggga ttatggttta 5460

tggacaacaa tcaaaacaga cgcaccatat caagagtatt tagaagcaag tcaatataat 5520

aactggatag cttacgttac aatacctggt gaatattata ttacaggtaa ccaaatggaa 5580

ttatttagag acgctccaga agaaattaaa aaagtgggtg catggttacg tgtttcaagt 5640

ggtaacgccg ttggtgaagt cagacaaaca ttagaggcta atgttaaaga gcacaaagag 5700

tactttagta acgttaatgc ggaaacgaaa catcgtgagt atgattgggt taagaaagga 5760

taatgttgca atgaaatcac aacaacaagc gaaagattgg atatataaac atgagggtgt 5820

tggcgttgac tttgatggag catatggttt tcaatgtatg gacttagcag ttgcttatgt 5880

ttattacatt actgacggta aagttcgcat gtggggtaac gccaaagacg ccattaacaa 5940

cgactttaaa ggtttagcag cggtgtatga aaatacacct agctttaaac ctcaattagg 6000

tgacgttgct gtatacatta attctcaata tgggcatatt caatgtgtaa caagtggaaa 6060

tcttgattat tatacatgct tagaacaaaa ctggttaaat ggtggatatg atggttggga 6120

aaaagcaaca ataagaacac attattatga cggtgttacg cattttattc gtccaaaatt 6180

ttcaaatagt gatagtaaag tattagaaaa aaatattcaa caaactaaca actggaaaca 6240

aaaccaatac ggcacatatt acagaaatga aaatgctaca tttacatgtg gttttttacc 6300

aatatttgct cgtgtcggta gtccgaaatt atctgtgctt aatggctatt ggttccaacc 6360

aaacggctat acaccatatg acgaagtttg tttatcagac aggtatgtat ggattggtta 6420

caattgggaa ggtacacgtt attatttacc agtgagacaa tggaacggta aaacaggtaa 6480

tagttacagt gttggtattc cgtggggggt gttctcataa tgggtatttt aggttttttc 6540

tttgagttta gttggaaacg atacaaataa gaggtgtgaa caatggctga tagaatcgta 6600

agaagtttaa gacaagttga aacaatagac aggttagcag attttttaac agaagaaaat 6660

gacttaatca gtacatcaga cggacatatt tatgtccgta ctgatactgg ttattataaa 6720

ttaacatttt ataatgattt aaaaacattg attaataaat acagtggtca aatagaaaat 6780

catgatattg caattaatga taataaagag aaaatatcaa catttctaga gaaaataaaa 6840

aaattacaac caatgattga tagtaataaa aaagagattg attcattaaa agaaaaagat 6900

gtcatattaa atgaaagttt agaacaacat caaacacaat taaatgaatt tgaaaaatca 6960

atgttacagt atgatgataa atatgaaaca cttacacaat cgttaaacgc tactaaagat 7020

agtgtaggac gaaacacaaa tgaaattaat ttaattaaag ctaatactgg tgcagaaaac 7080

attgacgcgt taaaaagaga attagctgaa gttaaaaaaa gtatcaatct tgataaaata 7140

aaagatattg aacaacagat tgaattatta aaatctaaac aaaacaatga caacacaatt 7200

caagaaatac aagaggatat taataagtta aaacaaaatt caagtgctgg gaaacttgaa 7260

agtttagaac aaaccattaa tgacatcaaa gcaaatgcca accttgataa gataaaagag 7320

ttagaaacaa aattaaacag tattaaccaa aaagattata cacaggatat taattcaatt 7380

aaatctgaca tcgctgcttt aaaaacaaat aatgataaaa tatcaaaaat tgaaaaagat 7440

attcaagaat taaaagatag accagttgtt gacggaaacg gacatattga tttatcaaaa 7500

tatgataatg atattaatga tttaaaacaa aaaacatcaa caaatgaatc aagtattaac 7560

actttatcaa caagagtgga caacttaaat atagatacta aaattgcaca atctaaatca 7620

gaaattgaac aaaattttga tcaaaaaatc aacagtgcaa aattacaatt taatgataca 7680

ggttggcaag atatatcgct agaaagtggt atagttgcaa gtgatagcaa cggtggttat 7740

cccgcaccgc aatatcgtat tgtaacaatt aatggtgtta aaaccataca attaaaaggg 7800

gtattaaaag ggattaagaa aaacggtgat attaaattag gtacgattaa cgctaactta 7860

aaatcaacac atcactacac acaatgtgcg attgattcga aaatgattaa tacaagatta 7920

tatttaaact ttagtaatga attacatttt gttacatcaa attatagcga tagtgactta 7980

acaaatggag ataaacgttt tgcaatagat acacaaatca ttgaataaaa atgttataat 8040

agtcgtataa attatttata cgactatttt ttatggaggt aaaaatgaga aaattaacaa 8100

attttaaatt tttctataac acaccgttta cagactatca aaatacaatt cattttaata 8160

gtaataaaga gcgtgatgat tattttttaa acggtcgtca ttttaaatca ttagactatt 8220

ccaaacaacc gtataatttt atacgtgata gaatggaaat caatgttgat atgcagtggc 8280

atgacgcaca agggattaac tacatgacgt ttttatcaga ttttgaggac agacgctatt 8340

acgcttttgt gaatcaaatc gaatatgtga atgatgttgt ggtaaaaata tattttgtga 8400

ttgatactat tatgacgtat acacaaggta atgtattaga acaactttca aacgttaata 8460

ttgaacgtca acacttatca aagcgtacgt ataactatat gttgccgatg ttacgtaaca 8520

atgatgatgt gttaaaagta tcaaataaaa actatgtgta taaccaaatg caacagtatt 8580

tggaaaattt agtgttattc cagtcaagcg ctgatttatc aaagaaattt ggtacgaaaa 8640

aagagccaaa cttagatacg tctaaaggta cgatatatga caatatcaca tcgccagtca 8700

acttatacgt tatggaatat ggtgacttta ttaactttat ggataaaatg agtgcatatc 8760

catggattac acaaaacttt caaaaggttc aaatgttacc taaagatttt attaatacaa 8820

aagatttaga ggacgttaag acaagtgaaa aaattactgg attaaagaca ttaaaacagg 8880

gtggaaaatc aaaagaatgg agtttaaacg atttatcatt aagtttcaca aagcttcaag 8940

agatgatgtt gtctaaaaaa gacgagttta aacatatgat acgtaatgag tacatgacga 9000

ttgaatttta tgactggaac ggtaacacaa tgttacttga cgctggtaaa atttcacaaa 9060

aaacaggtgt taagttacgt acaaaatcca tcattggtta tcataatgaa gtgcgagtat 9120

atccagttga ttataacagt gctgaaaacg atagaccgat acttgctaaa aataaagata 9180

tattaattga tacaggttca ttcttaaata ccaatataac atttaatagt tttgcgcaag 9240

tgcctatatt aattaataac ggaattttag gacaatcaca acaagccaat agacagcgta 9300

atgcagaaag tcaattaatc acaagtcgta tagataatgt attaaatggt agtgacccaa 9360

aatcacgttt ttatgacgct gtaagtgtag caagtaattt aagtccaacc gctttatttg 9420

gtaagtttaa tgaagaatat aatttctaca aacaacaaca ggcagaatat aaagatttag 9480

ccttacaacc accatctgtg acagaatcag aaatgggaaa cgcattccaa attgcaaata 9540

gcattaacgg tttaacgatg aaaattagtg taccgtcacc taaagaaatt acatttttac 9600

aaaaatatta tatgttgttt ggttttgaag taaatgacta taatacattc attgaaccta 9660

ttaacagcat gactgtatgc aactatttaa aatgtacagg tacgtatacc atacgtgaca 9720

ttgaccctat gttaatggaa caattaaaag caattttaga atctggtgtg agattttggc 9780

ataatgacgg ttcaggtaat ccaatgttac agaacccgtt aaataataaa tttagagaag 9840

gtgtataaaa tgaatgaggt aaaattaaga tttacggaca cagaagcatt tcatatgttc 9900

atatatgcag gtgatttaaa gttactatat tttttatttg ttttgatgat tatagatgtt 9960

gttactggtt ttgctaaagc aattaaaaat aataatctat ggtctaaaaa atcaatgaaa 10020

ggttttgcta aaaaattatt gatattctgt attatcattt tagctaacat cattgaccag 10080

attttacaat taaaaggtgg cttactcatg attacgattt tctattatat cgctaatgag 10140

ggcttatcta tcgtagaaaa ttgtgcagaa atggacgtat tagtaccaga acaaattaaa 10200

gataaattaa gagtaattaa aaacgattct gaaaagggtg ataataatga acgaccaaga 10260

gaagatagat aaatttacgc attcgtatat taatgatgat ttcggtttaa cgatagacca 10320

gttagtccct aaagtaaaag ggtatggacg ctttaatgta tggctaggtg gtaatgaaag 10380

taaaatcaga caagtattaa aagcagtaaa agagataggt gtgtcaccta ctctttttgc 10440

tgtatatgaa aaaaatgaag ggtatagcgc tggtttaggt tggttgaacc atacatctgc 10500

acgaggtgac tatttaacag acgctaaatt cattgcaaga aaattagtat cacaatcaaa 10560

acaagcagga caaccgtctt ggtatgacgc aggtaacatc gttcactttg tacctcaaga 10620

cgtacaaaga aaaggtaatg cagattttgc taaaaatatg aaagcaggta caatcggacg 10680

tgcgtatatt ccattaacag cagcggctac ttgggcggca tattatcccc taggtttgaa 10740

agcgtcatat aataaagtac aaaactatgg taatcctttt ttagacggtg caaatactat 10800

tttagcatgg ggtggtaaat tagacggtaa aggtggttca cctagtgatt cgtctgacag 10860

tggtagtagt ggtgacagtg gtagttcact gctcgcttta gcaaaacaag ccatgcaaga 10920

attattaaaa aaagtacaag acgcattaca atgggatgta cacagtattg gtagtgataa 10980

attttttagt aatgattatt ttacattaca aaaaacattt aacaacacat atcatattaa 11040

aatgacgatt gggctacttg attcattaaa aaaactgatt gatagtgtgc aagtagatag 11100

tggggatagt agttcaaacc ctactgatga tgacggagac cataaaccaa ttagtggtaa 11160

gtcagtcaaa ccaaatggta aaagtggtcg cgtcattggt ggtaactgga cgtatgcaca 11220

gttaccagaa aaatataaaa aagcaattgg tgtaccttta ttcaaaaaag aatacttgta 11280

caaaccaggt aacatatttc ctcaaacggg taatgcagga caatgtacag aattaacatg 11340

ggcatatatg tcacaattac atggtaaaag acaaccaaca gacgacggtc aaataacaaa 11400

cggtcaacgt gtgtggtacg tatataaaaa gttaggtgca aaaacaacac ataatccaac 11460

agtagggtat ggtttttcaa gtaaaccacc atacttacaa gcaacagcat atggcattgg 11520

tcacacaggt gtcgttgtag cagtatttga cgatggttca ttcttagtag ctaactataa 11580

tgtaccgccg tacgttgcac cgtcacgcgt agtattatat acacttatta atggtgtacc 11640

agaaaatgca ggtgataata ttgtattctt tagtggtata gcttaattaa ctatggtata 11700

atgaaaacat gctagtaatg ctagtaaata aaatacaaaa cataatcaat tttcgtacac 11760

atttttcatg ttatctcaaa agaaaaaggc gactgttatt taacagttgc ctttttttaa 11820

ttcatcgtgt tcacgtttta atatatgcaa attagattta ttatgcactg aacgtacaac 11880

tggaaataag tcattaagtg agaatgaacc gatgtcactt tcaatataaa gaatatcatc 11940

aaattgacta tggtcaaaat tttctctagc gtcttttaag ataaattcac gtttcatatt 12000

aagttcatca gtaaaatatt catcatatac attaccgcat acaatttctg ttttagacgg 12060

ataaatcgat atcgtaccct gttcgttata gatactttta ttgttttcta ttatcgcacc 12120

gtcaaagaat tgttcacgta caaaggtttc aaaatcgacg cttgtatcaa aggcgctttt 12180

cggtatacca gcagaagcaa ttttaatctt tccattcact tcatatgcat attttttatg 12240

attcagtaca aacatcttat ctatctgttc gttttcaata tcccatttac ctaaggctat 12300

cgggtcgaat aaactggggt tcaataaggg tttaacaacg gatttcatat acaaactatc 12360

agtatcgcaa taaataaaat tgtcgtcaat ttcattttca gttaagtatt ggaaaggtac 12420

caataagtta tataatgaac gtgatgtgac aaatgtagag aataatatat tacgttcagt 12480

gtttttgtaa ccgttaatga tattatatag ttcgttgtta tcatctaaac ggaataagtt 12540

aaaatgtgaa cgtaatgcag gtatgccata taatccgtta agtacaactt tagacaacat 12600

aacctcctca tttgagtaag ggtgttcgtt gatgtcatca gtaatatgat agtcgtaagg 12660

tgatgtcatg ttgattttgt tttttaactt accttgtgtt ttaataaaat agttttgaaa 12720

tataatatca cgtgcatgaa agtattcaca ttcatatatc acaaacgaat taacacgtat 12780

atgcgtgcaa tcaatacccg taatgtcttg aatcattctt aatgtatttg tattaatatt 12840

aacgtaatca ttatcattat tatagtattt tacaatcatt tgacgtaata cacgtgattt 12900

gattttaatt aataaatcat tgttaaatac atctttatca atcttatata atgaaaaata 12960

attgtcatca tctaaaaaag tagggattaa tgtaggttct gaataatgtt cataaaagta 13020

taaccatgtc ggaattttct catgatacat cacataagga taactggaat tgatatcaat 13080

agaaaaacaa ggctcatcaa taagtttgtt tatgtattta gtgttataca tatttaaacc 13140

accacgataa aatgatttga tatagtcata aaaattcata tcatggaaat ggtaatgtgt 13200

atatgatatt ttaatatctt gatattgatt gagtaactga aaacgcgtca tttgattatt 13260

taaatacgat tccataatat tcaatgaaaa tgttaatttg ttatagtcaa aatttggaaa 13320

tatatcacta taatgaatat ggcacatacc taatataatc acgtcattat gaatgtatgt 13380

aagttgttca ggtgtgagtt tatcaaaaca ctttacggca tagtcatagg cttcactatc 13440

tgacatgtcg ttatctttat caaatatcgt gtaattaaaa tctgttttaa gttggtcgtc 13500

tgttaaataa ccaccgtcaa gcaacttttt acctaatgtt gcaattgatg tatttgtttt 13560

cataaagtta tcaataatat taaatttaaa tccatttaaa aacattgtta agtctaaatt 13620

aatagacgat ttcacacgtt tttctaaaat cacattttga tttttagcta aaatagtagc 13680

ctcttgcatt tttagtgtgt gttcgttttc ttctgcagat tttaaatata tattttcacg 13740

tgtgatatta tcaaaataac gcatggtatc tttaagtaaa aaatggttgt catacttatt 13800

acagttatgt gcaatcatga taatatctgt ttttgactta gtgattgtat cacgtcgttt 13860

cacatacgta taaaatgcgt cataaaacga ttcaaaacta ggaaatactt ctacatcaat 13920

ctcataacca ttaaaccaac caattgctac tgaatacgtt acgtttttat atttggttgg 13980

tttttttctt ccgttaactt tattgtacgc taatgtttct atatcccagt ataaaatcat 14040

tcgacgttca tgtttatgat attgcatgca ttctagtaat cccataatct tacacacctt 14100

ttataagccg tattgtttca ttaaatactt ctttgtattt tcaatatagt tatcttcata 14160

tattttttct tttctttcaa attcactcat atttttcttc atttcatttt ttatatgaaa 14220

ttttataatt ttattcatat ctaaatataa atatctatca ttatcaacaa cgtaattttt 14280

tgagtaagcg ttatcaaaat gtaaattgct tggattgtaa taataacgct ccatgttttc 14340

tttataaaac atatcttctc ttaaataaat aacattgtca tctatatctt tgattttagt 14400

acaaaattca tattgttttg tataaggtat aacaataata ttagcattaa atgtatcaac 14460

attatacata atttttatat atttatcgtc agttttaata tagaaaaaat caccgttttg 14520

attgatatga tttcttaaat tatcatctgc caaattatat tcgttaaatt caaactcgcc 14580

agtagtcata gcgtcatcgt ttgaattgaa tgcccgtgtg ttacgctttt catttacgta 14640

atcgtttctt cgcatttcta aaaaaatgtt tttgtaaagt cgtgatgtgt tcattttatg 14700

tttttgtaat aagttatata tatttaaatt ggataatata ggacttgaaa agttgactgc 14760

attacctagt aaaaacattt tagggaagcc gatataatca acattaccat ggttacggtc 14820

gattgattca taaattgttt ttaacttatc ccactcgtca attaaatagt catcttcaag 14880

tgctaaaaat tcatcatata taatgatagg gtagtgtttt aaaaagttag aatgatattt 14940

taaatcagtt gcactattca aatctgtaat cacaccgatt tccttatctt gatagatgat 15000

agctaaatag tccctagcgc ttctgaatgt gacacgctta gatttgaata gtgggttttt 15060

gtctatgatt tcctcaataa aatcacgata agcgtcacgt aatgtataat gacgtgataa 15120

taaagtaaat ttaatatcaa gttttatagc taaataaata aagaatgaaa catagttgaa 15180

cgattttccg tcagaacggt ttgaaataga tatgtaatag tctatatcat cattcatgag 15240

ttcatcaact aattctattt gattatagtt atctggtatt ttttttctga catgattgac 15300

agtattttga taatctctta ccatgtctaa acgattttgt ttcaccatgt ttttgctcct 15360

tataatagtt tatgatgtcg tttacagtat taaaattagt cttcaaatgt tgcataatat 15420

aaaaagttat acctcacatc ttcatcatca atagtagtca ctggtctgtc tgatttacca 15480

atttctttgt ataaagtgtc aatttccttt atatatttat acatagaaga attattattt 15540

tttgcttgta attcatataa agcatattta tgctttttag cgtttttatt attagattca 15600

tctttacggt tatatatttc aagtatatag tttaattgtt catgtctttt acctcttacc 15660

aatgatacag catttgcata tgacacgttt ctttcttttg gaaaataggg caaatgtgcg 15720

aaatgtttcc atgcgtctat gtacgcctct tgtaaatctt tatcatcaaa tttaaaatta 15780

acagtactaa aatcatttaa aaacaattct ttttcctgct cttttcttgc ttctctttct 15840

tttttccatt tatccatttc ggacgtatgt ctaaccattg ctaacgacct ccatataaac 15900

catatataac cactaaaaag ataatgtaga atataatcaa tgtagtaaat aaaacaccaa 15960

atgacacacg tatatgcatt gtcataagta ttacaagtgt aattaaaaat gctaaaagga 16020

aaacaataat aatatctaat aggttattca tggtctttca atgctccata atcatatatc 16080

attttacctt gataaaacac tactaaatga ctttgaaaag ggtcgtcaaa ataatctaat 16140

aattcatcaa tagtaatatc tgtaaaaatt tcccttttaa ataatgggtt taaatcttct 16200

cgataaaaaa catcaagtaa atcaaatcta tatttataaa tattgatatt aatatcaata 16260

gtaaataaat cttggttcaa attataatca tgattatatc cctcaaaaaa tctattttaa 16320

tattacctga atttattatt acaacacaat tattattatt agaaacaaaa gtatattttt 16380

tatcattaaa tttatcttta ttttttaata tatagttgat taaatcaact gaattaaatg 16440

ttttttttat tttcattttt atatctcctt aatgtatttt acacaaagat tatatgcacc 16500

ttttttgtaa aagtttgagt caaaataact atatattacc ttaactttat ttattttttt 16560

cgaattgttc aatttcatgt tcatatattt cattaattga tacattgtat aataatacgg 16620

cagtgtatat tttttccatt gtttagcacc tcataaaaat aggggataaa tatcccctat 16680

gaaattgtat taaaatgata cttgaccaaa gttgattgag taaccttttt gacctttttt 16740

attttcatac tcataaattg tgaattgaac ttcaccagca ttgataatgt taacaacgtc 16800

ctcgtcttga cgcatttctt taattaattc agttaagtga ttcggtaagt ttacgttata 16860

gtcgtcagtg acgataacac cttgttcacc gaattttgat tctttgtttg tgaataatgc 16920

tctaacgata tactcttttt tcataccgta tttttctact aattctgata gtttgataaa 16980

ttctctttct ttttcctcaa attcgaatct cgctaatgtg ttttggtgtc ttgataaaat 17040

atcttttacg tttgtcattt ttatttctcc tcttatttaa attatttgct ttctgcaatt 17100

gcaatttgta gtaaatcatt gtaataaact tgcatagttt tagtatgtcg tgtagtggat 17160

aaaagtttgt gtgtattagg taataagtct ttcgcttgtg attttgataa atgatactcg 17220

tgaagtggga taaattcttc aacatattca tttttatcat ctaaataatg aaaaatataa 17280

ccttttattc gtaatgtaac aatatcatca ggtttcatta ttatatcact cctttctaaa 17340

aaacgtaaac gttatacgtt tcataaaatc ctttgtgcat attccattgt tctattgggt 17400

catcaccagc aatgtaagat aaaatagatt ctggtttagt ttcgttgttt agttcatcat 17460

ttaagaattt aacaacagaa ctattatagt ttaataatag ttgttggcaa gctgatacta 17520

aattaatagc attgtcgaaa gtataagctg gattccattg aatcaactta ttgaatagtt 17580

gcaacatttc agtataagct tgaccttttt cttctggtgc attatcaata ttaaccatta 17640

ttaacactcc ttaattcatt ccttatttca tcaacgattt ttttaggtga attatggtct 17700

aattgttcaa aatcgtcctt ttcaagtaca aataatgtta aatcataagt tgatgtatta 17760

cccataacaa taactatatt accattttta aaatgtaagt ttgtaaaggt tgtacatttt 17820

ccattttgtt acctccttga tttgattaca tacatagtat agcaaacgtt taaaagtttt 17880

gtcaatggtt tttcttaaaa agtttaaata atttaaaaat aatatttaat agaagaaatt 17940

agattttaaa tacaaatcat aattttgaat aaaagtcaat agatacataa attttgtatt 18000

tgatgaatat gttataggtt agataagttg ttaagttgtc aaacagtatt tataagttta 18060

gtaaagaaat gataagtgaa tttataagtt ttgatttgta taatcgttta ttttaaacgg 18120

tgggtgggtg taatttt 18137

<210> 4

<211> 17641

<212> DNA

<213> Podoviridae picovirinae Ahjdlikevirus BP-39

<400> 4

aatttacacc tccccaccgt ttaaaataaa cgattataca aatcaaaact tataaattaa 60

cttattattt ctttactaaa cttataaaaa ctgtgcaaca acttcaaaac ttatctaacc 120

tataacatat tcatcaaata caaaatttat gtatctattg acttttatca aaatttatga 180

tttgtattta aaatctaatt tcttctatta aatagtattt ttaaattatt taaacttttt 240

taagaaaaac cattgacaaa acttttaaac gtttgctata ctatgtatgt aataaaatca 300

aggaggtaac aaaatggaaa atgtacaacc tttacaaact tacatttttt ttaaaaaaaa 360

tatagttatt gttatgggta atacatcaac ttatgaatta acattatttg tacttgaaaa 420

ggacgatttt gaacaattag atcataattc acctaaaaaa aaatcgttga tgaaataagg 480

aatgaaataa atgatttaag gagtgataat aatggttaat gttgataacg cacctgaaga 540

aaaagggcaa gcctatactg aaatgttgca actattcaat aagttgattc aatggaatcc 600

agcttatact ttcgacaatg ctattaattt agtatcagct tgccaacaac tattattaaa 660

ctataatagt tctgttgtta aattcttaaa tgatgaacta aacaacgaaa ctaaaccaga 720

atctatttta tcttacattg ctggtgatga ctcaatagaa caatggaata tgcacaaagg 780

attttatgaa acgtataacg tttacgtttt ttagaaagga gtgatataat aatgaaacct 840

gatgatattg ttacattacg aataaaaggt tatattcttc attatttaga tgataaaaat 900

gaatatgttg aagaatttat cccacttcac gagtatcatt tatcaaaatc acaagctaaa 960

gacttattac ctaatacaca caaactttta tccactacac gacatactaa aactatgcaa 1020

gtttattaca atgatttact acaaattgca attgcagaaa gcaaataatt taaataagag 1080

gagaaataaa aatgacaaac gtaaaagata ttttatcaag acaccaaaaa acattagcga 1140

gattcgaatt tgaggaaaaa gaaagagaat ttatcaaact atcagaatta gtagaaaaat 1200

acggtatgaa aaaagagtat atcgttagag cattattcat aaacaatgaa tcaaaattcg 1260

gtaaacaagg tgttatcgtc actgacgact ataacgtaaa cttaccgaat cacttaactg 1320

aattaattaa agaaatgcgt caagacgagg acgttgttaa cattatcaat gctggtgaag 1380

ttcaattcac aatttatgag tatgaaaata aaaaaggtca aaaaggttac tcaatcaact 1440

ttggtcaagt atcattttaa tacaatttca taggggatat ttatccccta tttttatgag 1500

gtgctaaaca atggaaaaaa tatacactgc cgtattatta tacaatgtat caattaatga 1560

aacatatgaa catgaaattg aacaattcga aaaaataaat aaagttaagg taatatatag 1620

ttattttgac acaaactttt acaaaaaagg tgcatataat ctttgtgtaa aatacattaa 1680

ggagatataa aaatgaaaat aaaaaaaaca tttaattcag ttgatttaat caactatata 1740

ttaaaaaata aagataaatt taatgataaa aaatatactt ttgtttctaa taataataat 1800

tgtgttgtaa taataaattc aggtaatatt aaaatagatt tttttgatgg atataatttg 1860

aaccaagatt tatttactat tgatattaat atcaatattt ataaatatag atttgattta 1920

cttgatgttt tttatcgaga agatttaaac ccattattta aaagggaaat ttttacagat 1980

attactattg aagaattatt atattatttt gacgaccttt ttcaaagtca tttagtagtg 2040

ttttatcaag gtaaaataat atatgattat agagcattga aagaccatga ataacctatt 2100

agatattatt attgttttcc ttttagcatt tttaattaca cttgtaatac ttatgacaat 2160

gcatatacgt gtttcatttg gtgttttatt tactacattg attatattct acattatctt 2220

tttagtggtt atatatgggt tatatggagg tcgttagcaa tgcttagaca tacgtccgaa 2280

atggataaat ggaaaaaaga aagagacgca agaaaagagc aggaaaaaga attgttttta 2340

aatgatttta gtactgttaa ttttaaattt gatgataaag atttacaaga ggcgtacata 2400

gacgcatgga aacatttcgc acatttgccc tattttccaa aagaaagaaa cgtgtcatat 2460

gtaaatgccg tatcattggt aagaggtaaa agacatgaac aattaaacta tatacttgaa 2520

atatataacc gtaaagatga atctaataat aaaaacgcta aaaaacataa atatgcttta 2580

tatgaattac aagctaaaaa taataattct tctatgtata aatatattaa agaaattgac 2640

actttataca aagaaattgg taaatcagac agaccagtga ctactattga tgatgaagat 2700

gtgaggtata actttttata ttatgcaaca tttgaagact aattttaata ctgtaaacga 2760

cattataaac tattataagg agcaaaaaca tggtgaaaca aaatcgttta gacatggtaa 2820

gagattatca aaatgctgtc aatcatgtca gaaaaaaaat accagataac tataatcaaa 2880

tagaattagt tgatgaactc atgaatgatg atatagacta ttacatatct atttcaaacc 2940

gttctgacgg aaaatcgttc aactatgttt cattctttat ttatttagct ataaaacttg 3000

atattaaatt tactttatta tcacgtcatt atacattacg tgacgcttat cgtgatttta 3060

ttgaggaaat catagacaaa aacccactat tcaaatctaa gcgtgtcaca ttcagaagcg 3120

ctagggacta tttagctatc atctatcaag ataaggaaat cggtgtgatt acagatttga 3180

atagtgcaac tgatttaaaa tatcattcta actttttaaa acactaccct atcattatat 3240

atgatgaatt tttagcactt gaagatgact atttaattga cgagtgggat aagttaaaaa 3300

caatttatga atcaatcgac cgtaaccatg gtaatgttga ttatatcggc ttccctaaaa 3360

tgtttttatt aggtaatgca gtcaactttt caagtcctat attatccaat ttaaatatat 3420

ataacttatt acaaaaacat aaaatgaaca catcacgact ttacaaaaac atttttttag 3480

aaatgcgaag aaacgattac gtaaatgaaa agcgtaacac acgggcattc aattcaaacg 3540

atgacgctat gactactggc gagtttgaat ttaacgaata taatttagca gatgataatt 3600

taagaaatca tatcaatcaa aacggtgatt ttttctatat taaaactgac gataaatata 3660

taaaaattat gtataatgtt gatacattta atgctaatat tattgttata ccttatacaa 3720

aacaatatga attttgtact aaaatcaaag atatagatga caatgttatt tatttaagag 3780

aagatatgtt ttataaagaa aacatggagc gttattatta caatccaagc aatttaaatt 3840

ttgataacgc ttactcaaaa aattacgttg ttgataatga tagatattta tatttagata 3900

tgaataaaat tataaaattt catataaaaa atgaaatgaa gaaaaatatg agtgaatttg 3960

aaagaaaaga aaaaatatat gaagataact atattgaaaa tacaaagaag tatttaatga 4020

aacaatacgg tttatagaag gtgtgtaaga ttatgggatt actagaatgc atgaaatatc 4080

ataaacatga acgtcgaatg attttatact gggatataga aacattagcg tacaataaag 4140

ttaacggacg aaaaaaacca accaaatata aaaacgtaac gtattcagta gcaattggtt 4200

ggtttaatgg ttatgagatt gatgtagaag tatttcctag ttttgaatcg ttttatgacg 4260

cattttatac gtatgtgaaa cgacgtgata caatcactaa gtcaaaaaca gatattatca 4320

tgattgcaca taactgtaat aagtatgaca accatttttt acttaaagat accatgcgtt 4380

attttgataa tatcacacgt gaaaatatat atttaaaatc tgcagaagaa aacgaacaca 4440

cactaaagat gcaagaggct actattttag ctaaaaatca aaatgtgatt ttagaaaaac 4500

gtgtgaaatc gtctattaat ttagacttaa caatgttttt aaatggattt aaaattaata 4560

ttattgataa ctttatgaaa acaaatacat caattgcaac attaggtaaa aagttgcttg 4620

acggtggtta tttaacagac gaccaactta aaacagattt taattacacg atatttgata 4680

aagataacga catgtcagat agtgaagcct atgactatgc cgtaaagtgt tttgctaaac 4740

tcacacctga acaacttaca tacattcata atgacgttat tatattaggt atgtgccata 4800

ttcattatag tgatatattt ccaaattttg actataacaa attaacattt tcattgaata 4860

ttatggaatc gtatttaaat aatcaaatga cgcgttttca gttactcaat caatatcaag 4920

atattaaaat atcatataca cattatcatt tccatgatat gaatttttat gattatatca 4980

aatcatttta tcgtggtggt ttaaatatgt ataacactaa atacataaac aaacttattg 5040

atgagccttg tttttctatt gatatcaatt ccagttatcc ttatgtgatg tatcatgaga 5100

aaattccgac atggttatac ttttatgaac attattcaga acctacatta atccctactt 5160

ttttagatga tgacaattat ttttcattat ataagattga taaagatgta tttaacaatg 5220

atttattaat taaaatcaaa tcacgtgtat tacgtcaaat gattgtaaaa tactataata 5280

atgataatga ttacgttaat attaatacaa atacattaag aatgattcaa gacattacgg 5340

gtattgattg cacgcatata cgtgttaatt cgtttgtgat atatgaatgt gaatactttc 5400

atgcacgtga tattatattt caaaactatt ttattaaaac acaaggtaag ttaaaaaaca 5460

aaatcaacat gacatcacct tacgactatc atattactga tgacatcaac gaacaccctt 5520

actcaaatga tgaggttatg ttgtctaaag ttgtacttaa cggattatat ggcatacctg 5580

cattacgttc acattttaac ttattccgtt tagatgataa caacgaacta tataatatca 5640

ttaacggtta caaaaacact gaacgtaata tattattctc tacatttgtc acatcacgtt 5700

cattatataa cttattggta cctttccaat acttaactga aaatgaaatt gacgacaatt 5760

ttatttattg cgatactgat agtttgtata tgaaatccgt tgttaaaccc ttattgaacc 5820

ccagtttatt cgatccgata gccttaggta aatgggatat tgaaaacgaa cagatagata 5880

agatgtttgt actgaatcat aaaaaatatg catatgaagt gaatggaaag attaaaattg 5940

cttctgctgg tatacctaaa agcgcctttg atacaagcgt cgattttgaa acctttgtac 6000

gtgaacaatt ctttgacggt gcgataatag aaaacaataa aagtatctat aacgaacagg 6060

gtacgatatc gatttatccg tctaaaacag aaattgtatg cggtaatgta tatgatgaat 6120

attttactga tgaacttaat atgaaacgtg aatttatctt aaaagacgct agagaaaatt 6180

ttgaccatag tcaatttgat gatattcttt atattgaaag tgacatcggt tcattctcac 6240

ttaatgactt atttccagtt gtacgttcag tgcataataa atctgatttg catatattaa 6300

aacgtgaaca tgatgaatta aaaaaggcaa ctgttaaata acagtcgcct ttttcttttg 6360

agataacatg aaaaatgtgt acgaaaattg attatgtttt gtattttatt tactagcatt 6420

actagcatgt tttcattata gcatagttaa ttaagcaata ccactgaaga atacaatatt 6480

atcaccagcg ttatgaggaa caccattaat caatgtatat aatacaaccc gtgacggtgc 6540

cacgtatggt gggacgttat agtttgctac taagaatgaa ccatcgtcaa atactgctac 6600

aacgacacct gtgtgaccaa tgccatatgc tgttgcttgt aagtatggtg gtttacttga 6660

aaaaccataa ccaacagtag ggttgtgtgt tgtttttgca cctaactttt tatagacgta 6720

ccatacacgt tgaccgtttg tcacttgacc gtcgtctgtc ggttgtcttt taccatgtaa 6780

ttgtgacata tacgcccatg ttaattctgt acactgacct gcattacccg tttgaggaaa 6840

tatgttacct ggtttgtata aatattcttt tttgaataaa ggtacaccaa ttgctttttt 6900

atatttttct ggtaactgtg cgtatgtcca gttaccacca atgacgcgac cacttttacc 6960

attaggtttg actgatttac cactaattgg tttatggtct ccgtcatcat cagtagggtt 7020

tgaactacta cccccactat ctacttgcac gctatcaatc agttttttta atgaatctag 7080

tagcccaatc gtcattttaa tatgatatgt gttgttaaat gttttttgta atgtaaaata 7140

atcattacta aaaaatttat cactaccaat actgtgtaca tcccattgta atgcgtcttg 7200

tacttttttt aataattctt gcatggcttg ttttgctagg gctagtaatg aatttcctcc 7260

actatcagaa ctactatcag atgaaccact attaggtgaa ccacctttac cgtctatttt 7320

accaccccac gcaagaatag tattcgcacc gtctaaaaaa ggattaccat agttttgtac 7380

tttattatat gacgctttaa gtcctagggg ataatatgcc gcccaagtag cagctgctgt 7440

taatggaata tacgcacgtc cgattgtacc tgctttcata tttttagaaa aatctgcatt 7500

accttttctt tgtacgtctt gaggtacaaa atgtactgga ttaccgtaat cataccaaga 7560

cggttgccca gcttgttttg attgtgatac taattttctt gctatgaatt ttgcatctgt 7620

taaataatca ccacgtgcag acgtatgatt taaccaacct aaaccggcac tatacccttc 7680

atttttttca tatacagcaa aaagagtagg cgacacacct atctctttta ctgcttttaa 7740

tacttgtctg attttacttt cattaccacc aagccataca ttaaagcgtc catacccttt 7800

tactttaggg actaactggt ctatcgttaa accgaaatca tcattaatat atgaatgtgt 7860

aaatttatct atcttctctt ggtcgttcat tattatcact cttttcagta tcatttttaa 7920

tgactcttaa tttatcttta atttgatctg ggactaacac gtccatttct gcacaatttt 7980

ctacgataga taagccctca ttagcgatat aatagaaaat cgtaatcatg agtaagccac 8040

cttttaattg taaaatctgg tcaatgatgt tagctaaaat gataatacag aatatcaata 8100

attttttagc aaaacctttc attgattttt tagaccatag attattattt ttaattgctt 8160

tagcaaaacc agtaacaaca tctacaatca tcaaaacaaa taaaaaatat agtaacttta 8220

aatcacctgc atatatgaac atgtgaaatg tttctgtttc cgtaaatctt aattttacct 8280

cattcattta tacacctact ctaaatttat tatttaacgg gttctgtaac attggattac 8340

ctgaaccgtc attatgccaa aatctcacac cagattccaa aatagctttt aattgttcca 8400

ttaacatagg gtcaatgtca cgtattgtat aagtacctgt acattttaaa tagttgcata 8460

cagtcatact gttaattggt tcaataaatg aattataatt atttacttca aaaccaaaca 8520

acatataata tttttgtaaa aatgtaattt ctttaggtga cggtacacta attttcatcg 8580

ttaaaccgtt aatgctattt gcgatttgga atgcatttcc catttctgat tcagtcactg 8640

acgggggttg taaggctaaa tctttatatt ctgcctgttg ttgtttgtag aaattatatt 8700

cttcattaaa cttaccaaat aaagccgttg gacttaaatt acttgctaca cttacagcgt 8760

cataaaaacg tgattttggg tcactaccat ttaatacatt atctatacga tttgtaatta 8820

attgactttc tgcattacgc tgtctattgg cttgttgtga ttgtcctaaa attccgttat 8880

taattaatat aggtacttgc gcaaaactat taaatgttat atttgtattt aagaatgaac 8940

ctgtatcaat taatatatct ttatttttag caagtatcgg tctatcattt tcagcactgt 9000

tataatctac tggataaact cgaacttcat tatgataacc aataatagat tttgttctta 9060

gtttcacgcc tgttttttct gaaattttac cagcgtcgag taacattgta ttcccattcc 9120

aatcataaaa ttcaatcgtc atgtactcat tacgtatcat atgcttaaat tcatcttttt 9180

tagacaacat catctcttga agctttgaga aacttaatga taaatcgttt aaactccatt 9240

cttttgattt tccaccttgt tttaacgtct ttaatccagt aattttttca cttgttttaa 9300

cgtcctctaa atctttttta ttaataaagt ctttaggtat catttgaacc ttttgaaagt 9360

tttgtgtaat ccatggatag gcactcattt tatccataaa attgataaaa tccccgtatt 9420

ccatgacgta taagttaact ggtgatgtga tattgtcata tatcgtacct ttagacgtat 9480

ctaagtttgg ctcttttttc gtaccaaatt tctttgataa atcagcgctt gactggaata 9540

acactaaatt ttccaaatac tgttgcattt ggttatacac atagttttta ttcgatactt 9600

ttaacacatc atcattgtta cgtaacattg gtaacatata gttatacgtg cgttttgata 9660

agtgttgacg ttcaatatta acgtttgaga gttgctctaa tacattacct tgcgtgtacg 9720

tcataatagt atcaatcaca aaatatattt taaccacaac atcattcaca tattcgattt 9780

gattcacaaa cgcgtaatag cgtctatcct caaaatctga taaaaacgtc atgtagttaa 9840

tcccttgtgc attatgccac tgcatatcaa cattgatttc cattctatca cgtataaaat 9900

tatacggttg ttttgaatag tctaacgatt taaaatgacg accatttaaa aaataatcat 9960

cacgttcttt attactatta aaatgaatcg tgttttgata gtctgtaaac ggtgtgttat 10020

agaaaaattt aaaatttgtt aattttctca tttttacctc cataaaaaat agtcgtataa 10080

ataatttata cgactattat atcattttta ttcaatgatt tgtgtatcta ttgcaaaaag 10140

tttataacca tttgaaagct cactatcgct ataatttgat gtaacaaaat gtaattcacc 10200

tttaaaattt aagtacattc ttgtatttat cattttatta tcaatcgcac attgtgtgta 10260

gtgatgtgtt gtttttaagt ttgcgttaat cgtacctaat ttaatatcac cgtttttctt 10320

aataccttta aatacacctt ttaattgtat tgtttttacg tcattgattg taacaatgcg 10380

atattttaaa ggtggataag cattactatt attatctatt gtaataccac tttcaagttg 10440

cacattttgc caacctgtat catttacact tgtttttgaa gatttgattt gttcttgtaa 10500

ttctgtttta gttgattcga tttttttact tgtttcaatt gtgttgtttg aaaccgttga 10560

agctaagttt tcaatacttt gtttattttg tctgattgtt tcttttgtag cgatgatatc 10620

ttgtttattc gtttcaattg ctaatttgtt ttttgtattt tcatcatcta ataacaaaat 10680

agcgtcattg tgattgttta atttatttgt atgttctgat tgtatatcag ataaattttt 10740

aattttttta tcttgttgta tattatcctc tttaatatga ataatatctg tagcgttttg 10800

agatatatta tttttatttg tagcgatatc atttttattt ttatcgatcg cttttgtgtt 10860

tgtattaatt ttttctaata attcatcttt aaatgttagc ttataataat cctcatcacg 10920

tcttatatat atgttatcgt ctttggttgt gattaagtcg tttgcttcaa ctaaattgtc 10980

gtttaacttc tctaatgaat caatacccct taaacttctt acaattctat cagccattgt 11040

tcacacctct tatttgtatc gtttccaact aaattcaaag aaaaatccta aaatacccat 11100

tatgagaaca ctccccacgg aataccaaca ctgtaactat tacctgtttt accgttccat 11160

tgacgtactg gtaaataata acgtgtccct tgccagttat aaccaatcca tacatacccg 11220

tctgataaac aaacttcgtc atatggtgta taaccattcg gttggaacca atagccatta 11280

ggttcagata atttcggact accgacacgt gcaaatattg gtaaaaaacc acatgtaaat 11340

gtcgcattct catttctgta atatgtgcca tattggtttt gtttccattt tccgaatgtg 11400

tttacttttg atgtttctaa ttcgttgctg ttactagcag aaaattttgg acggataaag 11460

tgtgttacac cgtcgtaata atgtgttctg attgttgctt tttcccaacc gtcaaaaccg 11520

ccacctaacc agttttgctc taaacatgta taataatcta aattaccact taacacacat 11580

tgaatatgtc catattgccc atattgtcca tttgtatata cagcaacgtc acctaattga 11640

ggtttaaagc tcggtgtatt ttcatacacc gttgctaatc ctttaaagtc gttgttaatg 11700

gcgtctttag cgttacccca catacgaact ttaccgtcag taatgtaata aacataagca 11760

actgctaagt ccatacattg aaaaccatat gctccatcaa agtcaacgcc aacaccctca 11820

tgtttatata tccattcttt agcttgttgt tgtgatttca tttatatcac tcctatttaa 11880

tgttttgcta cccaatcata ctcacgatgt gtatttttta ctgttacaag actataaaat 11940

tctttatatg ttgatgaatt tattaataac gtttgtctta cttcacctga aacgttacca 12000

cttgatactt gtaaccacgc acctgcatca ccaataccat taggtttatc tttaaattgg 12060

ttcatttgtg ttgaagtaat gtaatattct ccaggtaatg taattttagc aatccaataa 12120

ccaaattttt tagcctcaac gtattctttt tcagttgaat tagtatcaat aaccgaccat 12180

ttaccaaatt caaatttttg tgtatttaag ttatatgtga aacttcttat tagtttcatc 12240

atttttctta atcctgaatt tcttgttaat tcttgatatc cacctaactg ttgtgttttt 12300

ggtgatacaa ataaaaacca gcctgcatca tcattgatat atgggaaatc atccataact 12360

ttagtatgtt ctgtcatcat ataataaaat ccagtttcgg taatttggct taaacttgtc 12420

acaccatctc ttattgataa agctctaccg tcatctttcg ttagtttata gttttgacca 12480

ccttttaacg ttaatgcaac aaaacgttca tattcaccag tttgaaagaa accatacaat 12540

aagttttgtc tttttccacc accagcagtt gtatatgcaa ttaataaaga ttgtttttta 12600

gttctaggat taacgtataa atatataccc tcaggctctc taaaattatc tctaggattt 12660

tcaacaccat gttcaaatga aacatcgttt aaataataat cgtatacttt tgattttgtt 12720

ttaaaactat atttttgaat taatgtttta ctatctagag ctgacctacc acttaaccag 12780

tataaatcat caccataaac tgcaatacct tgcataggtc tgtatggtgt gttttctttt 12840

acatcaattt gtagttcttt ttctacattg tcaatgtgat taattacatc ttctcttgaa 12900

cgtacttgta ttaaaccacc gccatatcta aatactaatt tgtcattttc ttcatccata 12960

ataggcgtaa aatattcgtg tgaagatgct ggcgtgaaat cagttaatgc ttttgcatca 13020

tctactgtta atgttgtatt atctctataa gcgatttgta caagttttga aagtgctaca 13080

tgatacaacc atatttttat ctcaccgtta ctttttcttt ctaaagcaat attagtacca 13140

tgaccaccct ctacaatacg catactagaa attaaatcac cactaggcgt taatttgtta 13200

atccaaaaac cctctttttc ttgtgagtcg gattgtgtag agtacatttg atttgtttct 13260

ctatcaatta atatactttg gtttacagcg ttacgaacac caccaaagcc cgttacaaac 13320

tttggttcaa gctcatttaa ttcaaaccca ttaacgaaac ggtcaatatc tttaattaag 13380

tctttcactt ctgctttaaa gtcattcatt tgtttcattt cagcaacttt aaatacagca 13440

aaagctgaag ttagtccagc agaatatttt gtaaactcgt catgaatgat tttatcaatc 13500

gtaccgtcgt ttaaccatcc tctaaataat tctttagcgt catctggaaa ttttttcatt 13560

aaatcgtccc aatttttgaa acgttttttt aattcaccgt catattccca aatacgacgt 13620

gccaatactt caatcagttg tgatagtttt gaaacataat cataatacga ttttgaatta 13680

gtattataat cagctctatc atcatagaac ggtgtatatg tttctcttgt tttatatatc 13740

tcatctatga atggacgaat atcctcaaaa tatttaaatt cattttcatt atatgccatt 13800

atttaaccac cttaccaaat ttgtaaaaaa catcttttat caaattcgtt taatattttt 13860

tttcttaaat catatgcttt atcgatatta tcgattaagt attgttttgt gaattgtgta 13920

cctttagcat ttcctttttg attttgatta cgttttgcgt tttgattact ttcactactt 13980

gatttattca ctgatttacc attatcaatg gtattgttat cagcaaattg caatgttgta 14040

ttatcaacat cgatattaac ctcactttga ggtaatgtcg caaatgcgtt tctgtttgct 14100

gtcatacctg ttgaattgtc taatgatgta gcattttgat ttgatgtttc atctgtgtta 14160

tttgttgtgt cttcattgtg ttctgtaaat ccttgtgatt gaagatattt ttcaacttca 14220

cttgatgaat aaacaacgtt taaataatcc tcatgtgtaa tacataccgt aatcacttgc 14280

atgccaaacg cttcaaccgt ttgcctgtta atttctctat ctaaaaagtg aatcgtaaat 14340

gattttttaa aaagtaaatc tgataactca tttttaagtg aaaaaccttt aaatactttt 14400

tcatttacaa ttacttgtac atccttatca aatttaagca ttttttgcat aaattgaaat 14460

tcatcatcat aaaaggttaa tttatcgtta tttacaaatt cattaaaacc ttttttaatc 14520

agttctgact ttataaaatc atataatgtc atggtatatc tagccattta catcactact 14580

ttcatcttta aacagtgtat caaccattga aattttagac gtagtttcat catcataata 14640

cggtttaata tctaaaccat aacgttttga taaaaatgta atcggttcac gtccttttaa 14700

ataaatatta ctatttgacg tagtaaaacc acgattactt ttcgcttctt catcagatac 14760

accgctttct ttatcaacag cgagtgaatt tatgcctaaa tagttactta attcactgat 14820

tttattctga tattctcgct tcatttctgt taaagcagga atcactgaat tacttgttaa 14880

atcaataata tcatcatctg cgttgaacat cggtgacatc ttaacaaatg gtgcgccgtt 14940

ataaatttct gatacaagtt gattaattga ttcatcgtta atatctgatt taaatatctt 15000

gctgaatttt gcttgcataa tcaatgaaaa acgagataaa acaacctcag ctaattcatc 15060

tgtataatgt tctataattt caatatcact attatattga atcggtttat tttgcataac 15120

aacaaaattt ccactcatgc aattatcgta ttgcttatga atttgtagac attcatcagg 15180

tattaaatag tctggaacaa tgaaataaat atcatctttt gttaatcgtt tttgaaattg 15240

gaagttaaag ttagatgaga aatttggtgc ttggttaaaa taagtattgt taacataacc 15300

aagaatcata atttgtttat ttctcgcttc tcctaccaca acattaatgt tttgtcttaa 15360

tgcagattct aactgaataa aatctatacc aaccgtatca cgattggtat agtttattag 15420

taggggtaaa aattccaaat aacgattaaa cataagacgt ttaaaacggt tacgatgttc 15480

aactactctt ttattaattt gttttgacag ttcaacatat aaacctcttt tgttatttgt 15540

cataatttac ctcctatgtt tcactatctg gttctggttt aggtgttaca tcttggtcag 15600

taattaaaat tttgttaaag aatggactta cagctttaaa tgaatagtaa tgtatccaat 15660

gtgtaacctc atcatactca ccattataga atggttgttt taacatacct tttgtatagc 15720

gtttatattt aattgaatta atatccaaaa taaacgcata taaatctgat tttggtttga 15780

tttcttcaac gttacctgta aactctttaa gttttgaaac gtcataagtg aatacagcat 15840

ctaaaggaat agtatcaccg atttgtgctt gataatcacc gtaagcacgt aagaaatcaa 15900

ttgtatcttg attttgtaat ttaaattctt tcattacttt aaacacaccg cctaaatcat 15960

caaagctaat aacatggtct gtgaagtcaa taccagcgat ttggaaagtg ttcgcaattt 16020

ttgtatctaa taaataagat tttaatgaat ctgttgttaa aataacaatg tcttttaact 16080

tagacacagt tgtgtattga ccaatagcac caccagaagc acgatgtacc tcattatatt 16140

tagcgctgtt gttttgtaag ttgagaatag cttcaaaaac tttacttgct aaatcttctt 16200

ttgatgttgt tttgcgtatg tttgaatctg ataattgatt taacgagtaa tcaactaaca 16260

ttgctctcat ttctttttct tctaatacat taatatcaga aattttcttt ttataaacac 16320

ctaacgcata atttgtagcg tctgctaatg tttgaaaatt aaaacgaacg tcgttgttgt 16380

ttaatgtgaa tttttgtttt tttacaatac cactaccata tagcttagta gccatacgtg 16440

gataattacg ttttaacatt aattcttcgt tttttgataa gtccatatta attggaacag 16500

tatccataat tacatattct tctgaatatt gtccgataaa gtcttgctct tttgctaacc 16560

aattaaaacg gttacctaat gcaatatcaa ttaataatgt ttcattaatt ttagggaata 16620

aatatttatt aacaaatgtt tcaaacattg tgtttgtatt atcccactta tcaccaaaag 16680

tccaagattt tgaataatca tggttaaaat cttgtaatgc tgattttgct gatttagcaa 16740

ctaataaggc agattcattt tttgttgtag ccataatttt attattcctc ctctacgtct 16800

ccagaaaatg tttgcttaga tagtgaatga atttgaaccc cgtaactatc ttcactttta 16860

ttgacgtcaa ttgacatatt ttcatttaat tcagtacgtt tgtttaaacg tgaatcttca 16920

tatgatgttc ccatcataga acgcatgttg ttactctcat acatattatt ttcctcctaa 16980

tctaaatcta acttatcgac taattcttca tctgaatagt ctttgtcgtt gtcatctgct 17040

tcagtaacat ctgtttgtga ttgtggttgt ggttgttgca tttgtgatgt ttcaaaatta 17100

gtaaatcgtt gttctaatga agcgatacgt tgttctaaaa caacagggtc aaattttgaa 17160

ctatcttcgt cagttgtagt tggttctaat ttgttttcat tttcttcttc aattgtttct 17220

actgttttat cttcagtaga ttcttcggtt gattctgttg attcttcagt tgattctgaa 17280

gttgattctt cagttgattc ttcagttgat tctgaagttt cttctttgtc gtctggtttt 17340

acgatttcat caaattctgt catttagaca cctccaaata ttttataact aattatatca 17400

tagaatattt aaataagtaa attaaattta ttttaaatac aaatcataaa ttttgataaa 17460

agtcaataga tacataaatt ttgtatttga tgaatatgtt ataggttaga taagttttga 17520

agttgttgca cagtttttat aagtttagta aagaaataat aagttaattt ataagttttg 17580

atttgtataa tygtttattt taaacggtgg ggaggtgtaa atttacaata actttttccc 17640

t 17641

Claims (9)

1. Novel staphylococcus aureus phage, wherein the phage is a brachyury phage AHJD-like phage BP-39(Podoviridae picovirinae AHJD-like virus BP-39) with a preservation number of CCTCC NO: m2015144.

2. The bacteriophage of claim 1, wherein said brachyury phage AHJD-like phage genus BP-39(Podoviridae picovirinae AHJD-like virus B)P-39) has a morphological structure consisting of equiaxed capsids and retractable short tails, and has a potency of 2.0 × 10 when cultured for 6h at pH 3-9, with tolerance at 4-37 ℃, with an MOI of 0.01⁹pfu/mL。

3. The bacteriophage of claim 1, wherein the brachyury phage AHJD-like phage BP-39(Podoviridae picovirinae AHJD-likevirus BP-39) has the nucleotide sequence shown in SEQ ID No. 4.

4. A composition of Staphylococcus aureus phage comprising brachyury phage AHJD-like phage BP-39(Podoviridae picovirinae AHJD-like virus BP-39) and brachyury phage BP-13(Podoviridae sp.BP-13), Staphylococcus aureus phage BP-13A (Staphylococcus aureus phage BP-13A) or brachyury phage BP-14(Podoviridae sp.BP-14) or a combination of two or three thereof.

5. The composition of claim 4, wherein the composition comprises a combination of brachyury phage BP-13, staphylococcus aureus phage BP-13A, and brachyury phage AHJD-like phage BP-39, a combination of brachyury phage BP-13, brachyury phage BP-14, and brachyury phage AHJD-like phage BP-39, a combination of staphylococcus aureus phage BP-13A, brachyury phage BP-14, and brachyury phage AHJD-like phage BP-39, or a combination of brachyury phage BP-13, staphylococcus aureus phage BP-13A, brachyury phage BP-14, and brachyury phage AHJD-like phage BP-39.

6. The composition according to claim 5, wherein the ratio of the brachyury phage BP-13, Staphylococcus aureus phage BP-13A, and brachyury phage AHJD-like phage genus BP-39 is 1: 1, in terms of phage titer pfu/mL contained in a unit volume, the proportion of the brachyury phage BP-13, the brachyury phage BP-14 and the brachyury phage AHJD-like phage genus BP-39 is 1: 1, the ratio of the staphylococcus aureus bacteriophage BP-13A, the brachyury bacteriophage BP-14 and the brachyury bacteriophage AHJD-like bacteriophage genus BP-39 is 1: 1, the ratio of the brachyury phage BP-13, the staphylococcus aureus phage BP-13A, the brachyury phage BP-14 and the brachyury phage AHJD-like phage BP-39 is 1: 1.

7. A reagent or kit comprising the bacteriophage of any one of claims 1 to 3 or the bacteriophage composition of any one of claims 4 to 6.

8. Use of the bacteriophage of any one of claims 1 to 3 or the bacteriophage composition of any one of claims 4 to 6 for preparing a reagent or kit against human or animal-derived staphylococcus aureus.

9. Use of a bacteriophage, a bacteriophage composition, or a reagent or kit comprising a bacteriophage or a bacteriophage composition according to any one of claims 1 to 7 for the manufacture of a medicament for the treatment of human burn infections caused by staphylococcus aureus and bovine mastitis.

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