CN112844507A - Liquid-transfering suction head and equipment mechanism who moves liquid cover handle - Google Patents
Liquid-transfering suction head and equipment mechanism who moves liquid cover handle Download PDFInfo
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- CN112844507A CN112844507A CN202011642478.6A CN202011642478A CN112844507A CN 112844507 A CN112844507 A CN 112844507A CN 202011642478 A CN202011642478 A CN 202011642478A CN 112844507 A CN112844507 A CN 112844507A
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- liquid
- top plate
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- transfering
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
- B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
- B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
- B01L3/0227—Details of motor drive means
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
- B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
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Abstract
The invention discloses an assembly mechanism of a liquid transfer suction head and a liquid transfer sleeve handle, wherein the liquid transfer mechanism comprises a liquid transfer assembly and a liquid transfer driving part, and the liquid transfer assembly comprises a plurality of liquid transfer sleeve handles; the suction head placing box comprises a box body and a plurality of liquid-transferring suction heads, the liquid-transferring mechanism is arranged on the inserting mechanism, and the inserting mechanism is arranged on the lifting plate; the plug-in mechanism drives the liquid-transfering mechanism to descend, after the liquid-transfering sleeve handle of the liquid-transfering component is inserted into the inner hole of the liquid-transfering suction head, the plug-in mechanism grabs the box body of the suction head placing box, further applies pressure to the liquid-transfering mechanism, and the sleeve handle at the lower part of the liquid-transfering component is pressed into the inner hole of the suction head. In the process of press mounting of the suction head and the sleeve handle, the inserting mechanism grasps the box body of the suction head placing box and further applies pressure to the liquid transferring assembly, the downward press mounting force of the liquid transferring assembly is balanced by the pulling force applied to the suction head placing box by the inserting mechanism, and is not transmitted to the bearing mechanism of the liquid transferring equipment through the lifting plate, so that the bearing mechanism deforms to influence the inserting effect of the suction head.
Description
[ technical field ]
The invention relates to high-throughput pipetting equipment, in particular to an assembling mechanism of a pipetting head and a pipetting sleeve handle.
[ background art ]
The pipettor is an instrument for accurately removing a certain volume of solution, and before each pipetting, the pipettor firstly vertically inserts a pipetting sleeve handle into a pipette tip, and after the assembly of the pipette tip is completed, the liquid can be extracted.
The utility model with the patent number of CN201921356372.2 relates to a high-throughput and high-precision pipetting device, which comprises a mounting rack, a pipetting assembly and a lifting assembly for driving the mounting rack to lift, wherein the pipetting assembly comprises a piston rod base arranged on the mounting rack, a piston top plate positioned on the upper side of the piston rod base and a gun withdrawing head plate positioned on the lower side of the piston rod base; the mounting frame is provided with a driving mechanism for driving the piston top plate to move longitudinally, and the piston rod base is provided with a plurality of gun head rods which penetrate through the gun head withdrawing plate and are used for clamping gun heads, a piston rod matched with the gun head rods, a gun head pressing shaft for driving the gun head withdrawing plate to descend and a resetting piece for resetting the gun head withdrawing plate after descending; the piston rod and the gun pressing head shaft are driven by the piston top plate to move longitudinally; the gun head is installed through the lifting assembly.
The utility model relates to a high flux move liquid device, move liquid subassembly and need once only accomplish the supporting installation of great batch liquid-transfering sleeve handle (rifle head pole) and liquid-transfering suction head (rifle head). Because the assembly of liquid-transfering handle and liquid-transfering suction head belongs to interference fit, the liquid-transfering handle of liquid-transfering component can receive very large resistance when the liquid-transfering suction head is inserted in large quantities, and this assembly resistance can be transferred to supporting mechanism for supporting liquid-transfering component, and especially when the rigidity of supporting mechanism is relatively poor, the supporting mechanism for liquid-transfering component can take place great deformation, makes liquid-transfering component crooked, influences the cartridge effect of partial liquid-transfering suction head, leads to partial liquid-transfering handle and liquid-transfering suction head cartridge to fail.
[ summary of the invention ]
The invention aims to provide an assembly mechanism of a liquid-transfering sucker and a liquid-transfering sleeve handle, which has a good insertion effect.
In order to solve the technical problems, the invention adopts the technical scheme that the assembly mechanism of the liquid-transferring suction head and the liquid-transferring sleeve handle comprises a lifting plate, a liquid-transferring mechanism, an insertion mechanism and a liquid-transferring suction head placing box, wherein the liquid-transferring mechanism comprises a liquid-transferring assembly, a liquid-transferring driving part and an installation frame which are vertically arranged, and the liquid-transferring assembly comprises a plurality of liquid-transferring sleeve handles which are arranged in a matrix; the liquid-transfering sucker placing box comprises a box body, a pore plate and a plurality of liquid-transfering suckers arranged on the pore plate according to a matrix, wherein a liquid-transfering mechanism is arranged on an inserting mechanism, and the inserting mechanism is arranged on a lifting plate; the liquid-transfering mechanism is driven by the insertion mechanism to descend, after the liquid-transfering sleeve handle of the liquid-transfering component is inserted into the inner hole of the liquid-transfering sucker, the insertion mechanism grabs the box body of the liquid-transfering sucker placing box, further applies pressure to the liquid-transfering mechanism, and the liquid-transfering sleeve handle at the lower part of the liquid-transfering component is pressed into the inner hole of the liquid-transfering sucker.
The assembling mechanism, the inserting mechanism comprises an elastic pressing device, an inserting driving device and a press-fitting force application device; the upper edges of the two side plates opposite to the box body of the liquid-transferring suction head placing box comprise bearing flanges protruding outwards, and the insertion driving device comprises an insertion motor, a door-shaped motor base, a first lead screw nut assembly and two groups of first linear guide rail pairs; the elastic pressing device is arranged on the lifting plate, and the motor base is arranged at the lower part of the elastic pressing device; the mounting frame of the liquid transferring mechanism is mounted on two side plates of the motor base through two groups of first linear guide rail pairs; the insertion motor is vertically fixed on the top surface of the top plate of the motor base, a screw rod of the first screw rod nut component is connected with the lower end of the insertion motor, and a nut of the first screw rod nut component is fixed on a mounting frame of the liquid transferring mechanism; the press-fitting force application device comprises two groups of hooks for hooking the liquid-transferring suction head placing box and a hook folding mechanism, the upper parts of the two groups of hooks are respectively arranged at the two transverse ends of the top plate of the motor base, the hook heads of the two groups of hooks are positioned below the liquid-transferring assembly, and the direction of the hook heads is inward; when the insertion motor rotates, the first lead screw nut component drives the liquid transfer mechanism to move downwards, and the liquid transfer sleeve handle is inserted into an inner hole of the liquid transfer suction head; the plug-in motor continues to rotate, the motor base moves upwards by taking the nut of the first screw rod nut component as a fulcrum to drive the two groups of hooks to move upwards, the hook folding mechanism is triggered to fold the two groups of hooks at the same time, and hook heads of the two groups of hooks hook the bearing flange of the box body of the liquid-transferring suction head placing box; the cartridge motor further rotates, and first screw-nut subassembly drives the liquid-moving mechanism again and descends, will move liquid the inner hole of handle cartridge to liquid-moving suction head.
In the assembly mechanism, the elastic pressing device comprises two groups of second linear guide rail pairs, a plurality of first compression springs, compression spring guide columns, an upper top plate and a lower top plate, wherein the number of the compression springs is the same as that of the first compression springs; the upper top plate and the lower top plate are transversely arranged, the lower ends of the pressure spring guide columns are fixed on the lower top plate, and the plurality of pressure spring guide columns are transversely and separately arranged along the lower top plate; the upper top plate comprises guide post holes the number of which is the same as that of the first pressure springs, and the guide post holes are arranged along the transverse direction of the upper top plate; the upper top plate is fixed in front of the lifting plate, and the upper end of the pressure spring guide post penetrates through a guide post hole of the upper top plate; the first pressure spring is sleeved outside the pressure spring guide post and is positioned between the upper top plate and the lower top plate; the guide rails of the two second linear guide rail pairs are vertically fixed in front of the lifting plate and are arranged on two sides of the upper top plate and the lower top plate; the two ends of the lower top plate are respectively connected with the sliding blocks of the two groups of second linear guide rail pairs, and the top plate of the motor base is connected with the lower top plate.
In the assembly mechanism, the elastic pressing device comprises an L-shaped connecting plate and a limiting block, and two ends of the L-shaped connecting plate are respectively fixed on the sliding blocks of the two groups of second linear guide rail pairs; the L-shaped connecting plate is arranged below the lower top plate, the lower top plate is fixed on a vertical plate of the L-shaped connecting plate, and a top plate of the motor base is fixed on a transverse plate of the L-shaped connecting plate; the limiting block is fixed in front of the lifting plate and is positioned below the L-shaped connecting plate.
In the assembling mechanism, the hook folding mechanism comprises two sets of hook folding mechanisms which are symmetrically arranged left and right, and each hook folding mechanism comprises a guide rod, a guide sleeve seat, a second pressure spring, a guide plate and a contact rod; each group of hooks comprises a connecting rod, a second sliding block and two hook rods, the lower ends of the hook rods comprise hook heads, the upper ends of the two hook rods are respectively fixed at the front end and the rear end of the connecting rod, and the second sliding block is fixed on the bottom surface of the middle part of the connecting rod; the two sides of the top surface of the motor base top plate respectively comprise sliding grooves which are transversely arranged, the connecting rod is arranged above the motor base top plate, and the second sliding block is in sliding fit with the sliding grooves; the guide rod is transversely arranged above the top plate of the motor base, the inner side of the guide rod is in sliding fit with the guide sleeve in the guide sleeve base, and the guide sleeve base is fixed above the top plate of the motor base; the outer end of the guide rod is fixed on the connecting rod; the middle part of the guide rod comprises a flange, and the second pressure spring is sleeved on the guide rod and is positioned between the guide sleeve seat and the flange; the front end of the feeler lever is fixed on the flange of the guide rod, the guide plate is obliquely arranged in front of the lifting plate and is positioned above and outside the rear end of the feeler lever, and the rear end of the feeler lever is contacted with the guide surface of the guide plate.
In the assembly mechanism, the pipetting assembly comprises a plunger top plate, a plurality of plungers, a plunger cavity and a plurality of pipetting sleeve handles; the liquid transferring driving part comprises a liquid transferring motor and a second screw nut component; the mounting frame is in a door shape and comprises a top plate and two side plates; the guide rail of the first linear guide rail pair is vertically fixed on the inner side of the motor base side plate, and the sliding block of the first linear guide rail pair is fixed on the outer side of the mounting frame side plate; the nut of the first lead screw nut assembly is arranged on the top plate of the mounting frame; the plunger cavity is vertically fixed at the lower part of the mounting rack and between the two side plates of the mounting rack; the tops of the plungers are connected with a plunger top plate, and the lower parts of the plungers are inserted into plunger cavities corresponding to the plunger cavities; the upper ends of the pipetting sleeve handles are arranged at the bottom of the plunger cavity, and the inner holes of the pipetting sleeve handles are communicated with the plunger cavity corresponding to the plunger cavity; the liquid-transferring motor is fixed on the top plate of the mounting frame, a screw rod of the second screw rod nut component is connected with the lower end of the liquid-transferring motor, and a nut of the second screw rod nut component is connected with the plunger top plate.
In the assembly mechanism, the plunger cavity is connected with the inner sides of the side plates of the mounting frame, the liquid-moving driving part comprises a motor plate, two groups of third linear guide rail pairs and a driving frame, the driving frame comprises a top plate and two side plates, the motor plate is arranged at the front part of the top plate of the mounting frame, and the liquid-moving motor is fixed on the motor plate; the nut of the second screw-nut assembly is arranged on the top plate of the driving frame, the guide rail of the third linear guide rail pair is vertically fixed on the inner side of the side plate of the mounting frame, and the slide block of the third linear guide rail pair is fixed on the outer side of the side plate of the driving frame; two ends of the plunger piston top plate are respectively connected with the lower ends of the two side plates of the driving frame.
In the assembly mechanism, the lower part of the pipetting sleeve handle is conical, and the taper angle is 8-12 degrees; the upper part of the suction head is in an inverted cone shape, the upper part of an inner hole of the suction head is an inverted cone hole, and the cone angle of the inverted cone hole is matched with the cone angle of the lower part of the liquid-transferring sleeve handle; the middle part of the inverted cone hole comprises an inward-protruding interference fit annular belt, and the inward-protruding height of the interference fit annular belt is 0.08-0.12 mm.
In the press mounting process of the liquid-transfering suction head and the liquid-transfering sleeve handle, the inserting mechanism grasps the box body of the liquid-transfering suction head placing box and further applies pressure to the liquid-transfering assembly, the downward press mounting force of the liquid-transfering assembly is balanced by the pulling force applied to the liquid-transfering suction head placing box by the inserting mechanism, and cannot be transmitted to the bearing mechanism of the liquid-transfering equipment through the lifting plate, so that the bearing mechanism deforms to influence the inserting effect of the liquid-transfering suction head.
[ description of the drawings ]
The present invention will be described in further detail with reference to the accompanying drawings and specific embodiments.
FIG. 1 is a perspective view of a pipetting tip and pipetting handle assembly mechanism according to an embodiment of the invention.
FIG. 2 is a front view of the pipetting tip and pipetting handle assembly mechanism of an embodiment of the invention.
FIG. 3 is a left side view of the pipetting tip and pipetting handle assembly mechanism of an embodiment of the invention.
FIG. 4 is a top view of the pipetting tip and pipetting handle assembly mechanism of an embodiment of the invention.
Fig. 5 is a perspective view of the elastic pressing means according to the embodiment of the present invention.
Fig. 6 is a sectional view a-a in fig. 3.
Fig. 7 is a sectional view B-B in fig. 2.
FIG. 8 is a cross-sectional view of a pipetting mechanism according to an embodiment of the invention.
Fig. 9 is a cross-sectional view of a pipetting sleeve handle according to an embodiment of the invention.
Fig. 10 is a cross-sectional view of a pipetting tip according to an embodiment of the invention.
Fig. 11 is a perspective view of a pipette tip placement cassette according to an embodiment of the present invention.
FIG. 12 is a schematic view of the assembly mechanism of the pipetting tip and the pipetting handle according to the embodiment of the invention.
[ detailed description of the invention ]
The structure and principle of the pipetting tip and pipetting sleeve handle assembling mechanism of the embodiment of the invention are shown in fig. 1 to 12, and the mechanism comprises a lifting plate 01 arranged on a slide block of a Z-axis lifting mechanism of pipetting equipment, an inserting mechanism, a pipetting mechanism and a pipetting tip placing box 90 fixed on a base 02 of the pipetting equipment.
The inserting mechanism comprises an elastic pressing device 40, an inserting driving device 50 and a press-fitting force application device 60.
The elastic pressing device 40 comprises two groups of linear guide rail pairs 41, three compression springs 42, three compression spring guide columns 43, an upper top plate 44, a lower top plate 45, an L-shaped connecting plate 46 and a limiting block 47. The upper top plate 44 and the lower top plate 45 are transversely arranged, the lower ends of the pressure spring guide posts 43 are fixed on the lower top plate 45, and the three pressure spring guide posts 43 are transversely and separately arranged along the lower top plate 45. The upper top plate 44 includes three guide post holes 441, and the guide post holes 441 are arranged separately in the lateral direction of the upper top plate 44. The upper top plate 44 is fixed in front of the lifting plate 01, and the upper end of the pressure spring guide post 43 passes through the guide post hole 441 of the upper top plate 44 and is in sliding fit with the guide post hole 441. The pre-tightening compression spring 42 is sleeved outside the compression spring guide post 43 and is positioned between the upper top plate 44 and the lower top plate 45. The guide rails 411 of the two linear guide rail pairs 41 are vertically fixed in front of the lifting plate 01 and are separately arranged on both sides of the upper top plate 44 and the lower top plate 45. The L-shaped connecting plate 46 is disposed below the lower top plate 45, the lower top plate 45 is fixed on a vertical plate of the L-shaped connecting plate 46, and two ends of the L-shaped connecting plate 46 are respectively fixed on the sliding blocks 412 of the two sets of linear guide rail pairs 41. The limiting block 47 is fixed in front of the lifting plate 01 and is positioned below the L-shaped connecting plate 46.
The insertion driving device 50 comprises an insertion motor 51, a door-shaped motor base 52, a screw nut assembly 53 and two groups of linear guide rail pairs 54. The door-shaped motor base 52 comprises a top plate 521 and two side plates 522, wherein the top plate 521 of the motor base 52 is fixed on the transverse plate of the L-shaped connecting plate 46 of the elastic pressing device 40. The cartridge motor 51 is vertically fixed on the top surface of the top plate 521 of the motor base 52, and the lead screw 531 of the lead screw nut assembly 53 is connected with the lower end of the cartridge motor 51.
The press-fitting force application device 60 comprises two groups of hooks 60A and hook closing mechanisms 60B for hooking the bearing flanges of the box body 91 of the pipette tip placement box 90.
Each set of hooks 60A comprises a connecting rod 61, a slider 62 and two hook rods 63, the lower ends of the hook rods 63 are provided with a hook head 631, and the hook heads 631 face inwards. The upper ends of the two hook rods 63 are fixed to the front and rear ends of the connecting rod 61, respectively, and the slider 62 is fixed to the bottom surface of the middle portion of the connecting rod 61. The two sides of the top surface of the top plate 521 of the motor seat 52 are respectively provided with a sliding groove 523 which is transversely arranged, the connecting rod 61 is arranged above the top plate of the motor seat 52 and is fixed on the sliding block 62 at the bottom surface of the connecting rod 61 to be in sliding fit with the sliding groove 523, and the hook 60A can transversely move along the sliding groove 523.
The hook folding mechanism 60B includes two sets of hook folding mechanisms symmetrically arranged left and right, and each set of hook folding mechanism includes a guide rod 64, a guide sleeve seat 65, a pressure spring 66, a guide plate 67 and a feeler lever 68. The guide rod 64 is transversely arranged above the top plate 521 of the motor seat 52, the inner side of the guide rod is in sliding fit with a guide sleeve in a guide sleeve seat 65, and the guide sleeve seat 65 is fixed above the top plate 521 of the motor seat 52. The outer end of the guide rod 64 is fixed to the connecting rod 61 with a fixing seat 69. The middle part of the guide rod 64 is provided with a flange 641, and the pressure spring 66 is sleeved on the guide rod 64 and is positioned between the guide sleeve seat 65 and the flange 641. The front end of the feeler lever 68 is fixed to the flange 641 of the guide 64. The guide plate 67 is disposed diagonally in front of the elevating plate 01 above and outside the rear end of the trolley 68. The inner side of the guide plate 67 is a guide surface, and the rear end of the feeler lever 68 is kept in contact with the guide surface of the guide plate 67 by the elastic force of the compression spring 66.
The pipetting mechanism comprises a vertically arranged pipetting assembly 70, a pipetting drive part 80 and a mounting frame 88.
The pipetting driving part 80 comprises a pipetting motor 81, a screw nut component 82, a motor plate 83, two groups of linear guide rail pairs 84 and a driving frame 85.
The mounting bracket 88 is door-shaped and includes a top plate 881 and two side plates 882. The guide 541 of the linear guide pair 54 is vertically fixed on the inner side of the side plate 522 of the motor base 52, and the slider 542 of the linear guide pair 54 is fixed on the outer side of the side plate 882 of the mounting frame 88. The nut 532 of the lead screw nut assembly 53 is mounted on the top plate 881 of the mounting bracket 88.
The motor plate 83 is fixed to the front portion of the top plate 881 of the mounting rack 88, and the liquid-transferring motor 81 is fixed to the motor plate 83. The lead screw 821 of the lead screw nut assembly 82 is connected with the lower end of the liquid-transferring motor 81.
The driving frame 85 comprises a top plate 851 and two side plates 852, the nut 822 of the screw nut assembly 82 is installed on the top plate 851 of the driving frame 85, the guide rail 841 of the linear guide rail pair 84 is vertically fixed on the inner side of the side plate 882 of the mounting frame 88, and the slide block of the linear guide rail pair 84 is fixed on the outer side of the side plate 852 of the driving frame 85. The two ends of the plunger top plate 71 are respectively connected with the lower ends of the two side plates of the driving frame 85.
The pipette tip placement cassette 90 comprises a cassette body 91, a well plate 92 and 96 pipette tips 93 arranged in an 8 × 12 matrix on the well plate 92. The upper edges of two opposite side plates of the box body 91 of the pipetting tip placing box 90 are respectively provided with a bearing flange 911 which protrudes outwards, and the hook heads 631 of the two groups of hooks 60A are positioned below the outer side of the bearing flange 911.
The lower portion of the pipetting handle 74 is conical with a cone angle of 10 °. The upper part of the liquid-transfering sucker 93 is inverted cone-shaped, the upper part of the sucker inner hole 931 is an inverted cone hole, and the cone angle of the inverted cone hole is matched with the cone angle of the lower part of the liquid-transfering handle 74. A circle of inward-protruding interference fit annular belt 932 is arranged in the middle of the inverted cone hole, and the inward protruding height of the interference fit annular belt 932 is 0.1 mm.
The working process of the pipetting head and pipetting sleeve handle assembling mechanism provided by the embodiment of the invention is as follows:
1) the Z-axis lifting mechanism of the pipetting equipment drives the assembly mechanism to descend until the lower end of the pipetting sleeve handle 74 reaches about 2mm of the upper end surface of the pipette tip; the insertion motor 51 rotates, the feed screw nut component 53 drives the liquid-transferring mechanism to move downwards, the liquid-transferring sleeve handle 74 is pre-inserted into an inner hole of the liquid-transferring suction head 93, and the pressure of the liquid-transferring sleeve handle 74 pre-inserted into the liquid-transferring suction head 93 is the pre-tightening pressure of the elastic pressing device 40;
2) after the liquid-transferring sleeve handle 74 is inserted into the liquid-transferring sucker 93, the insertion motor 51 continues to rotate, the downward movement of the liquid-transferring sleeve handle 74 is blocked, the motor base 52 moves upwards by taking the nut of the screw-nut component 53 as a fulcrum, the three pressure springs 42 of the elastic pressing device 40 are compressed, the motor base 52 drives the two groups of hooks to move upwards, and the hook folding mechanism 60B is triggered at the same time; the feeler lever 68 of the hook closing mechanism 60B moving upwards along the motor base 52 moves inwards along the guide surface of the guide plate 67, the guide rod 64 drives the two groups of hooks to close, and the hook heads 631 of the two groups of hooks hook the two bearing flanges 911 of the box body 91 of the liquid-removing suction head placing box 90;
3) the plugging motor 51 further rotates, because the hook heads 631 of the two groups of hooks already hook the box body 91 of the liquid-transferring suction head placing box 90, the motor base 52 cannot move upwards relative to the liquid-transferring suction head placing box 90, the plugging motor 51 can only drive the liquid-transferring mechanism to move downwards, the interference resistance between the liquid-transferring suction head 93 and the liquid-transferring sleeve handle 74 is overcome, the liquid-transferring sleeve handle 74 is pressed into the inner hole of the liquid-transferring suction head 93, and the press-fitting of the liquid-transferring suction head 93 and the liquid-transferring sleeve handle 74 is;
4) the insertion motor 51 rotates reversely, and the hook folding mechanism 60B firstly releases the hook pipette tip 93 to put two groups of hooks: the elastic pressing device 40 pushes the motor base 52 to drive the two groups of hooks to move downwards and trigger the hook folding mechanism 60B at the same time; the feeler lever 68 moving downwards along the motor base 52 moves outwards along the guide surface of the guide plate 67 under the action of the second spring, the guide rod 64 drives the two groups of hooks to open, and the hook heads 631 of the two groups of hooks release the two bearing flanges 911 of the box body 91 of the liquid-removing suction head placing box 90;
5) in the process of releasing the box body 91 of the pipetting tip placing box 90 by the hook heads 631 of the two groups of hooks, the inserting motor 51 drives the pipetting mechanism to move upwards through the screw nut component 53, the inserting mechanism resets, the pipetting sleeve handle 74 of the pipetting component 70 drives the pipetting tip 93 to be drawn out from the box body 91 of the pipetting tip placing box 90, the Z-axis lifting mechanism of the pipetting equipment drives the assembling mechanism to ascend, the tip inserting work is completely finished, and the next liquid extracting work can be carried out.
After the insertion mechanism of the assembly mechanism of the pipetting tip and the pipetting sleeve handle inserts the sleeve handle of the pipetting assembly into the inner hole of the pipetting tip, the hook of the insertion mechanism grabs the bearing flange of the box body of the pipetting tip placing box, further pressure is applied to the pipetting assembly, the pipetting sleeve handle at the lower part of the pipetting assembly is pressed into the inner hole of the pipetting tip, the downward pressing force of the pipetting assembly is balanced by the pulling force applied to the bearing flange by the hook, and is not transmitted to the Z-axis lifting mechanism of the pipetting equipment through the lifting plate, so that the Z-axis lifting mechanism deforms to influence the insertion effect of the pipetting tip and the sleeve handle of the high-throughput pipetting equipment.
Claims (8)
1. The assembly mechanism of the liquid transfer pipette tip and the liquid transfer sleeve handle comprises a lifting plate, a liquid transfer mechanism and a liquid transfer pipette tip placing box, wherein the liquid transfer mechanism comprises a liquid transfer assembly, a liquid transfer driving part and a mounting frame which are vertically arranged, and the liquid transfer assembly comprises a plurality of liquid transfer sleeve handles which are arranged in a matrix; the liquid-transfering suction head placing box comprises a box body, a pore plate and a plurality of liquid-transfering suction heads arranged on the pore plate according to a matrix, and is characterized by comprising an inserting mechanism, wherein the liquid-transfering mechanism is arranged on the inserting mechanism, and the inserting mechanism is arranged on a lifting plate; the liquid-transfering mechanism is driven by the insertion mechanism to descend, after the liquid-transfering sleeve handle of the liquid-transfering component is inserted into the inner hole of the liquid-transfering sucker, the insertion mechanism grabs the box body of the liquid-transfering sucker placing box, further applies pressure to the liquid-transfering mechanism, and the liquid-transfering sleeve handle at the lower part of the liquid-transfering component is pressed into the inner hole of the liquid-transfering sucker.
2. The assembly mechanism of claim 1, wherein the cartridge mechanism comprises a resilient biasing means, a cartridge drive means and a press-fit force applying means; the upper edges of the two side plates opposite to the box body of the liquid-transferring suction head placing box comprise bearing flanges protruding outwards, and the insertion driving device comprises an insertion motor, a door-shaped motor base, a first lead screw nut assembly and two groups of first linear guide rail pairs; the elastic pressing device is arranged on the lifting plate, and the motor base is arranged at the lower part of the elastic pressing device; the mounting frame of the liquid transferring mechanism is mounted on two side plates of the motor base through two groups of first linear guide rail pairs; the insertion motor is vertically fixed on the top surface of the top plate of the motor base, a screw rod of the first screw rod nut component is connected with the lower end of the insertion motor, and a nut of the first screw rod nut component is fixed on a mounting frame of the liquid transferring mechanism; the press-fitting force application device comprises two groups of hooks for hooking the liquid-transferring suction head placing box and a hook folding mechanism, the upper parts of the two groups of hooks are respectively arranged at the two transverse ends of the top plate of the motor base, the hook heads of the two groups of hooks are positioned below the liquid-transferring assembly, and the direction of the hook heads is inward; when the insertion motor rotates, the first lead screw nut component drives the liquid transfer mechanism to move downwards, and the liquid transfer sleeve handle is inserted into an inner hole of the liquid transfer suction head; the plug-in motor continues to rotate, the motor base moves upwards by taking the nut of the first screw rod nut component as a fulcrum to drive the two groups of hooks to move upwards, the hook folding mechanism is triggered to fold the two groups of hooks at the same time, and hook heads of the two groups of hooks hook the bearing flange of the box body of the liquid-transferring suction head placing box; the cartridge motor further rotates, and first screw-nut subassembly drives the liquid-moving mechanism again and descends, will move liquid the inner hole of handle cartridge to liquid-moving suction head.
3. The assembly mechanism of claim 2, wherein the elastic pressing device comprises two sets of second linear guide rail pairs, a plurality of first compression springs, compression spring guide posts, an upper top plate and a lower top plate, wherein the number of the compression springs is equal to that of the first compression springs; the upper top plate and the lower top plate are transversely arranged, the lower ends of the pressure spring guide columns are fixed on the lower top plate, and the plurality of pressure spring guide columns are transversely and separately arranged along the lower top plate; the upper top plate comprises guide post holes the number of which is the same as that of the first pressure springs, and the guide post holes are arranged along the transverse direction of the upper top plate; the upper top plate is fixed in front of the lifting plate, and the upper end of the pressure spring guide post penetrates through a guide post hole of the upper top plate; the first pressure spring is sleeved outside the pressure spring guide post and is positioned between the upper top plate and the lower top plate; the guide rails of the two second linear guide rail pairs are vertically fixed in front of the lifting plate and are arranged on two sides of the upper top plate and the lower top plate; the two ends of the lower top plate are respectively connected with the sliding blocks of the two groups of second linear guide rail pairs, and the top plate of the motor base is connected with the lower top plate.
4. The assembly mechanism according to claim 3, wherein the elastic pressing device comprises an L-shaped connecting plate and a limiting block, and two ends of the L-shaped connecting plate are respectively fixed on the sliding blocks of the two groups of second linear guide rail pairs; the L-shaped connecting plate is arranged below the lower top plate, the lower top plate is fixed on a vertical plate of the L-shaped connecting plate, and a top plate of the motor base is fixed on a transverse plate of the L-shaped connecting plate; the limiting block is fixed in front of the lifting plate and is positioned below the L-shaped connecting plate.
5. The assembly mechanism of claim 2, wherein the hook closing mechanism comprises two sets of hook closing mechanisms symmetrically arranged left and right, and the hook closing mechanism comprises a guide rod, a guide sleeve seat, a second pressure spring, a guide plate and a contact rod; each group of hooks comprises a connecting rod, a second sliding block and two hook rods, the lower ends of the hook rods comprise hook heads, the upper ends of the two hook rods are respectively fixed at the front end and the rear end of the connecting rod, and the second sliding block is fixed on the bottom surface of the middle part of the connecting rod; the two sides of the top surface of the motor base top plate respectively comprise sliding grooves which are transversely arranged, the connecting rod is arranged above the motor base top plate, and the second sliding block is in sliding fit with the sliding grooves; the guide rod is transversely arranged above the top plate of the motor base, the inner side of the guide rod is in sliding fit with the guide sleeve in the guide sleeve base, and the guide sleeve base is fixed above the top plate of the motor base; the outer end of the guide rod is fixed on the connecting rod; the middle part of the guide rod comprises a flange, and the second pressure spring is sleeved on the guide rod and is positioned between the guide sleeve seat and the flange; the front end of the feeler lever is fixed on the flange of the guide rod, the guide plate is obliquely arranged in front of the lifting plate and is positioned above and outside the rear end of the feeler lever, and the rear end of the feeler lever is contacted with the guide surface of the guide plate.
6. The assembly mechanism of claim 2, wherein the pipetting assembly comprises a plunger top plate, a plurality of plungers, a plunger cavity, and a plurality of pipetting pockets; the liquid transferring driving part comprises a liquid transferring motor and a second screw nut component; the mounting frame is in a door shape and comprises a top plate and two side plates; the guide rail of the first linear guide rail pair is vertically fixed on the inner side of the motor base side plate, and the sliding block of the first linear guide rail pair is fixed on the outer side of the mounting frame side plate; the nut of the first lead screw nut assembly is arranged on the top plate of the mounting frame; the plunger cavity is vertically fixed at the lower part of the mounting rack and between the two side plates of the mounting rack; the tops of the plungers are connected with a plunger top plate, and the lower parts of the plungers are inserted into plunger cavities corresponding to the plunger cavities; the upper ends of the pipetting sleeve handles are arranged at the bottom of the plunger cavity, and the inner holes of the pipetting sleeve handles are communicated with the plunger cavity corresponding to the plunger cavity; the liquid-transferring motor is fixed on the top plate of the mounting frame, a screw rod of the second screw rod nut component is connected with the lower end of the liquid-transferring motor, and a nut of the second screw rod nut component is connected with the plunger top plate.
7. The assembly mechanism according to claim 2, wherein the plunger cavity is connected with the inner side of the side plate of the mounting frame, the liquid-moving driving part comprises a motor plate, two groups of third linear guide rail pairs and a driving frame, the driving frame comprises a top plate and two side plates, the motor plate is arranged in front of the top plate of the mounting frame, and the liquid-moving motor is fixed on the motor plate; the nut of the second screw-nut assembly is arranged on the top plate of the driving frame, the guide rail of the third linear guide rail pair is vertically fixed on the inner side of the side plate of the mounting frame, and the slide block of the third linear guide rail pair is fixed on the outer side of the side plate of the driving frame; two ends of the plunger piston top plate are respectively connected with the lower ends of the two side plates of the driving frame.
8. The assembly mechanism of claim 1, wherein the lower portion of the pipetting sleeve is conical with a cone angle of 8 ° -12 °; the upper part of the suction head is in an inverted cone shape, the upper part of an inner hole of the suction head is an inverted cone hole, and the cone angle of the inverted cone hole is matched with the cone angle of the lower part of the liquid-transferring sleeve handle; the middle part of the inverted cone hole comprises an inward-protruding interference fit annular belt, and the inward-protruding height of the interference fit annular belt is 0.08-0.12 mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011642478.6A CN112844507B (en) | 2020-12-31 | 2020-12-31 | Liquid-transfering suction head and equipment mechanism who moves liquid cover handle |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011642478.6A CN112844507B (en) | 2020-12-31 | 2020-12-31 | Liquid-transfering suction head and equipment mechanism who moves liquid cover handle |
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| Publication Number | Publication Date |
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| CN112844507A true CN112844507A (en) | 2021-05-28 |
| CN112844507B CN112844507B (en) | 2022-10-25 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110282425A (en) * | 2019-07-17 | 2019-09-27 | 安图实验仪器(郑州)有限公司 | Full-automatic sample transfer system |
| CN110290874A (en) * | 2017-01-13 | 2019-09-27 | 拜克门寇尔特公司 | For loading the kinematic system of suction nozzle |
| CN111229349A (en) * | 2020-03-17 | 2020-06-05 | 盐城工业职业技术学院 | Pipette capable of automatically sleeving and taking suction head |
| CN210815323U (en) * | 2019-08-21 | 2020-06-23 | 深圳市奥美顿科技有限公司 | High-flux and high-precision liquid transfer device |
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2020
- 2020-12-31 CN CN202011642478.6A patent/CN112844507B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110290874A (en) * | 2017-01-13 | 2019-09-27 | 拜克门寇尔特公司 | For loading the kinematic system of suction nozzle |
| CN110282425A (en) * | 2019-07-17 | 2019-09-27 | 安图实验仪器(郑州)有限公司 | Full-automatic sample transfer system |
| CN210815323U (en) * | 2019-08-21 | 2020-06-23 | 深圳市奥美顿科技有限公司 | High-flux and high-precision liquid transfer device |
| CN111229349A (en) * | 2020-03-17 | 2020-06-05 | 盐城工业职业技术学院 | Pipette capable of automatically sleeving and taking suction head |
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| CN112844507B (en) | 2022-10-25 |
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