CN112843122A - Endocrine regulating composition, application thereof and plant beverage - Google Patents

Endocrine regulating composition, application thereof and plant beverage Download PDF

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CN112843122A
CN112843122A CN202110284763.3A CN202110284763A CN112843122A CN 112843122 A CN112843122 A CN 112843122A CN 202110284763 A CN202110284763 A CN 202110284763A CN 112843122 A CN112843122 A CN 112843122A
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endocrine
parts
regulating
extraction
plant
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刘常青
张敏
宋力飞
刘乡乡
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Guangzhou Zeli Pharmtech Co ltd
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Guangzhou Zeli Pharmtech Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285—Aucklandia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention relates to an endocrine regulating composition which comprises the following components in parts by weight: 30-40 parts of truffle, 15-25 parts of agaricus blazei, 5-11 parts of longan pulp, 2-6 parts of emblic leafflower fruit, 1-4 parts of donkey-hide gelatin, 0.5-2 parts of sophora flower bud and 0.01-0.03 part of snow lotus culture.

Description

Endocrine regulating composition, application thereof and plant beverage
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to an endocrine regulating composition, application thereof and a plant beverage.
Background
The human body has eight major systems, wherein the endocrine system is an integrated regulation system of the body, plays an important role in regulating the growth, development, metabolism and reproduction of the whole body, supplements the nervous system and the immune system in the body and maintains the balance among all mechanisms in the body together. The regulation mechanism of the endocrine system to the body is mainly to regulate the basal metabolism, growth and development, reproductive aging and the like of the human body by secreting different hormones from different glands, and the normal secretion of the hormones is an important guarantee for the health of the human body. Due to the influence of factors such as environmental pollution, bad living habits, working pressure and the like, abnormal hormone secretion of a human endocrine system is caused, and the phenomenon of excessive or insufficient hormone secretion occurs, so that the human body has uncomfortable feeling or epidemic diseases, and particularly, the symptoms of female endocrine dyscrasia are obvious.
Female endocrine dyscrasia can produce the influence of different degree to women's physiology and psychology, mainly reflect in: unstable mood, frequent insomnia and dreamful sleep, concentrated attention, vexation and irritability; the face has color spots and dark and dull skin; excessive secretion of male hormone, hyposecretion of estrogen and weight gain; menstrual disorder, dysmenorrhea, hyperplasia of mammary glands, ovarian cyst, infertility and other gynecological diseases.
The ovary is an important reproductive organ of the female, has the functions of reproduction, ovarian hormone secretion, ovulation and the like, the secreted hormone has an important effect on the body health of the female, and abnormal ovarian hormone secretion can cause the increase of the morbidity of cardiovascular diseases of the female and threaten the life health of the female. In addition, an imbalance in ovarian hormone secretion can also adversely affect the normal functioning of the female's entire endocrine system.
The traditional conditioning methods for female endocrine dyscrasia mainly comprise western medicine treatment, traditional Chinese medicine treatment, diet conditioning and exercise conditioning. The western medicine treatment mainly adopts hormone medicines, such as flavonoid, which can supplement hormone hyposecretion in women after being taken, but the long-term taking of the medicines can generate dependence on the medicines, so that the gland function of the body secreting the hormone is reduced, and meanwhile, the medicines are absorbed into blood, so that the body can generate adverse symptoms such as obesity, edema, hypertension, menstrual disorder and the like. In the aspect of female endocrine treatment, the traditional Chinese medicine has better effects, can regulate qi and blood, remove blood stasis, dissipate stagnation, tonify thoroughfare and conception vessels, and keep the balance of hormone secretion in a body, but has generally longer treatment course and slow effect, and needs to be decocted every day for oral administration. Diet conditioning and exercise conditioning play important auxiliary roles in the female endocrine conditioning process, but cannot play a main treatment role, and take a long time. Although products for regulating endocrine are available on the market, the products are generally complex in compatibility, have certain dependence on human bodies after long-term use, and have insignificant curative effect.
Disclosure of Invention
Based on the composition, the invention provides the endocrine regulating composition capable of effectively regulating female endocrine, the application thereof and the plant beverage.
The technical scheme of the invention for solving the technical problems is as follows.
An endocrine regulating composition comprises the following components in parts by weight:
Figure BDA0002979984520000021
the inventor of the invention researches the compatibility and efficacy screening of a large amount of traditional Chinese medicinal materials through a large amount of experiments, and combines agaricus blazei murill, longan pulp and truffle as a monarch to directly influence or adjust endocrine and maintain ovaries; the emblic leafflower fruit and the pagodatree flower bud are matched as ministers and are cooperated with monarch drugs to jointly play roles in regulating endocrine, balancing organism functions, maintaining uterus and promoting metabolism; the donkey-hide gelatin is further matched to be used as an adjuvant to play a role in enriching blood, nourishing yin, improving ovary and regulating hormone; the saussurea involucrate culture has the functions of dispelling wind cold, regulating menstruation, promoting blood circulation, regulating immunity and resisting fatigue. The whole formula is combined according to monarch, minister, assistant and guide medicines, combines the efficacy and the specific proportion, and has synergistic effect, thereby effectively regulating the female endocrine and maintaining the ovary.
In some embodiments, the endocrine regulating composition comprises the following components in parts by weight:
Figure BDA0002979984520000031
in some embodiments, the endocrine regulating composition comprises the following components in parts by weight:
Figure BDA0002979984520000032
Figure BDA0002979984520000041
the invention provides an application of an endocrine regulating composition in preparing medicines or health products or drinks for regulating female endocrine and maintaining ovary.
A plant beverage comprising the endocrine regulating composition as described above.
In some embodiments, the plant beverage further comprises an adjuvant selected from at least one of maltodextrin, starch, beta-cyclodextrin and gum arabic.
The invention provides a preparation method of a vegetable beverage for regulating female endocrine, which comprises the following steps:
1) weighing the raw materials in the endocrine regulating composition;
2) extracting the truffle, the agaricus blazei murill, the longan pulp, the emblic leafflower fruit and the sophora flower bud to obtain an extracting solution;
3) and uniformly mixing the extracting solution with the donkey-hide gelatin and the saussurea involucrate culture to obtain the plant beverage.
In some embodiments, the method for preparing a plant beverage further comprises a step of performing solid-liquid separation on the extract to obtain a liquid phase, and concentrating the liquid phase, before the step of uniformly mixing the extract with the donkey-hide gelatin and the saussurea involucrate culture.
In some embodiments, after the step of blending in step 3), the method for preparing a plant beverage further includes a step of drying and sieving the blended mixture to obtain a plant solid beverage. In some embodiments, the preparation method of the plant beverage further comprises the step of adding auxiliary materials in the blending step of the step 3).
In some embodiments, the method for preparing a plant beverage comprises the following extraction conditions: the extraction temperature is 20-30 ℃, the extraction pressure is 20-60 Mpa, and the extraction flow rate is 0.5-1.5L/min.
Compared with the prior art, the truffle compound composition has the following beneficial effects:
the raw materials of the endocrine regulating composition can all come from natural plants, have the effect of regulating female endocrine, and have obvious curative effect, no side effect and dependence; when the traditional Chinese medicine composition is used by patients with endocrine dyscrasia, the color spots on the face become light, the skin glossiness is increased, the irregular menstruation, the dysphoria and other clinical symptoms are relieved, objective inspection indexes (follicle stimulating hormone, luteinizing hormone, estrogen, progestational hormone, prolactin and testosterone hormone) are improved, the endocrine is effectively regulated, the ovarian maintenance effect is realized, and the traditional Chinese medicine composition has an important significance for improving the female health.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a flow chart of a preparation method of the plant solid beverage of example 1.
Detailed Description
The endocrine regulating composition of the present invention and its application are described in further detail with reference to specific examples below. The present invention may be embodied in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise. The weight of the related components mentioned in the description of the embodiments of the present invention may not only refer to the specific content of each component, but also represent the proportional relationship of the weight among the components, and therefore, the content of the related components is scaled up or down within the scope disclosed in the description of the embodiments of the present invention as long as it is in accordance with the description of the embodiments of the present invention. Specifically, the weight described in the description of the embodiment of the present invention may be a unit of mass known in the chemical industry field, such as μ g, mg, g, and kg.
The invention provides an endocrine regulating composition, which comprises the following components in parts by weight:
Figure BDA0002979984520000061
aiming at the problems of female endocrine dyscrasia and ovary maintenance, the invention is formulated according to the compatibility principle of traditional Chinese medicine and the monarch, minister, assistant and guide and the theory of traditional Chinese medicine for treating diseases, and the agaricus blazei murrill, the arillus longan and the truffle are combined as the monarch to directly influence/regulate the endocrine and maintain the ovary; the emblic leafflower fruit and the pagodatree flower bud are compatible and used as ministers to regulate endocrine dyscrasia and protect uterus, and cooperate with monarch drugs to jointly play roles in regulating endocrine, balancing organism functions, maintaining uterus and promoting metabolism; the donkey-hide gelatin is further matched to be used as an adjuvant to play roles in enriching blood, nourishing yin, improving ovary and regulating hormone; the saussurea involucrate culture has the functions of dispelling wind cold, regulating menstruation, promoting blood circulation, regulating immunity and resisting fatigue. The whole formula is combined according to monarch, minister, assistant and adjuvant medicines, and has the effects of effectively regulating female endocrine and maintaining ovaries by combining with efficacy screening and specific proportion. Wherein, the pharmacological effects of the components are as follows:
truffle (Truffle) is a general name of mushrooms, belongs to the genus of the family of the tuber of the phylum ascomycete, the genus of the family of the tuber of the western mycocaceae, is a very precious and rare edible fungus, is rich in nutritional ingredients, and is rich in protein, polysaccharide, vitamins, minerals and other ingredients. The special active substance alpha-androstanol contained in the truffle is similar to the sex hormone component in human body, is a steroid compound with biological activity, and can effectively regulate female menstrual cycle and relieve menstrual pain. In addition, the polysaccharide contained in the truffle has natural antioxidation, the activity of scavenging free radicals is superior to that of vitamin C, and the truffle has the effects of delaying senility and maintaining beauty and keeping young.
Agaricus blazei Murrill (Agaricus blazei Murrill) belongs to Basidiomycetes, is rich in polysaccharide, protein, fatty acid, vitamins, trace elements and other components, contains mycelium protein and sterol, and has good inhibitory effect on uterine cancer cells, and Agaricus blazei Murrill polysaccharide has certain inhibitory effect on various cancer cells. In addition, the linoleic acid and the r-linoleic acid contained in the agaricus blazei can promote the secretion of hormones in organisms, have good functions of regulating endocrine and resisting oxidation, and have important functions on the aspects of ovary maintenance and endocrine regulation.
Phyllanthus emblica Linn (Phyllanthus emblica Linn) is a Phyllanthus plant of Euphorbiaceae, contains nutrient elements such as flavone, polysaccharide, polyphenol, protein, vitamin, fatty acid, alkaloid and the like, wherein the content of main active substances such as total phenolic acid and total flavone is high, has the effects of inhibiting the onset and development of various cancers such as cervical cancer, breast cancer, pancreatic cancer and the like, has a certain protection effect on uterus, and can inhibit the proliferation of cervical cancer cells.
Flos Sophorae Immaturus (Sophora japonica L.) is dried bud and flower of Sophora japonica of Leguminosae, and mainly contains rutin, betulin, Sophora japonica Michelia A, Sophora glycol, and other ketones, and contains rutin, flavone, amino acids, selenium, and other elements capable of regulating endocrine dyscrasia, scavenging in vivo free radicals and toxins, and has good antioxidant effect; has effects of accelerating metabolism, regulating organism balance, and supplementing nutrition.
Arillus longan (Dimocarpus longan Lour.) is arillus longan of Sapindaceae, and has effects of invigorating heart and spleen, nourishing blood, and tranquilizing mind. The arillus longan extract can reduce the content of prolactin in the serum of female rats, can obviously increase the content of progesterone and follicle stimulating hormone, and directly influences the secretion of secretion system hormone in organisms; the active substance extracted from dried arillus longan has good antioxidant activity, and the IC50 for scavenging DPPH free radicals is 2.2 g/L.
Colla Corii Asini (Colla Corii Asini) is skin of donkey of Equidae, and mainly contains protein, amino acids, microelements, dermatan sulfate and biological acid, and has effects of replenishing blood, nourishing yin, moistening lung, improving ovary and regulating hormone. The donkey-hide gelatin can enhance the expression of the ovarian apoptosis gene and weaken the expression of the apoptosis promoting gene, so as to achieve the effects of inhibiting the apoptosis of ovarian granular cells and further improving the ovarian function.
The Saussurea involucrate culture (Tissue culture of Saussurea involucrate) is a callus cell formed by dedifferentiation of isolated Tissue of Saussurea involucrate, and is cultured under certain conditions to obtain a cell product enriched with essence and effective components of Saussurea involucrate. The saussurea involucrate culture has the same biological activity as saussurea involucrate, and has pharmacological effects of dispelling pathogenic wind and cold, removing dampness, regulating menstruation, promoting blood circulation, regulating immunity, relieving fatigue, etc.
In some examples, the internal secretion regulating composition comprises the following components in parts by weight:
Figure BDA0002979984520000081
in some examples, the internal secretion regulating composition comprises the following components in parts by weight:
Figure BDA0002979984520000082
Figure BDA0002979984520000091
one embodiment of the invention provides application of an endocrine regulating composition in preparing medicines or health-care products or drinks for regulating female endocrine and maintaining ovary. It is to be understood that the endocrine regulating compositions provided herein can be applied to any form of product.
An embodiment of the present invention provides a plant beverage comprising the endocrine regulating composition as described above.
In some examples, the plant beverage further comprises an auxiliary material, wherein the auxiliary material is at least one selected from maltodextrin, starch, beta-cyclodextrin and Arabic gum.
An embodiment of the present invention provides a method for preparing a vegetable beverage for regulating female endocrine, including steps S10, S30, and S50.
Step S10: weighing the raw materials according to the mass parts in the endocrine regulating composition.
Step S30: extracting truffle, Agaricus blazei, arillus longan, fructus Phyllanthi and flos Sophorae Immaturus to obtain extractive solution.
It can be understood that truffle, agaricus blazei murill, arillus longan, emblic leafflower fruit and sophora flower bud can be respectively extracted, and the extracting solutions are mixed; or mixing at least two of truffle, Agaricus blazei, arillus longan, fructus Phyllanthi and flos Sophorae Immaturus together for extraction.
Step S50: and (4) uniformly mixing the donkey-hide gelatin and the saussurea involucrate culture with the extracting solution obtained in the step (S30) to obtain the plant beverage.
In some examples, after the raw materials are weighed in step S10, step S20 is further included.
Step S20: pulverizing the weighed raw materials.
It is understood that the truffle, the agaricus blazei, the longan pulp, the emblic leafflower fruit and the sophora flower bud can be respectively crushed to respectively obtain single fine crushed products or mixed to obtain mixed fine crushed products; or mixing the truffle, Agaricus blazei, arillus longan, fructus Phyllanthi and flos Sophorae Immaturus, and pulverizing to obtain mixed fine powder.
In some examples, in step S20, the pulverizing step uses a universal pulverizer, and the aperture is 0.8mm to 1.5 mm; preferably, the pore size is 1.2 mm.
In some examples, after weighing the raw materials in step S10, the donkey-hide gelatin is dissolved in hot water to obtain a hot solution. Wherein the temperature of the hot water is 80-90 ℃, and the concentration is 0.2-0.8 g/mL; preferably, the hot water temperature is 85 ℃ and the concentration is 0.4 g/mL.
It can be understood that the saussurea involucrate culture itself is in powder form, and the pulverization process is not required. Saussurea involucrate cultures used in this application were purchased directly from guangzhou fenvwei trade ltd.
In some examples, in step S30, the extraction solvent is water, and the amount of the solvent added is 10 to 25 times that of the extraction solvent; optionally, the addition amount of the solvent is 15-20 times; preferably, the amount of solvent added is 17 times the amount of solvent added.
In some examples, in step S30, the extraction is low-temperature extraction, the extraction temperature is 20 ℃ to 30 ℃, the extraction pressure is 20Mpa to 60Mpa, and the extraction flow rate is 0.5L/min to 1.5L/min; optionally, the extraction temperature is 25 + -1 deg.C, the extraction pressure is 25 + -5 MPa, and the extraction flow rate is 0.9L/min.
In some examples, the number of extractions may be performed one or more times as needed; preferably, the extraction is performed twice. It is understood that, when the extraction is performed a plurality of times, the residue obtained after the last extraction is extracted again.
In some examples, step S30 is performed by using a continuous extraction separation concentrator (HHLSE) of the patent device (zl200920304058. x) of cantonese zernike medical science and technology limited.
The traditional extraction methods of the compound materials mainly comprise a water decoction method, a reflux extraction method, an immersion method and the like, the extraction rate of effective ingredients in the materials is low, and part of the effective ingredients are damaged due to the influence of the extraction temperature, so that the utilization rate of the effective ingredients is low. The continuous extraction separation concentrator (HHLSE) is used for extraction, so that the method is rapid and simple, can completely extract effective components in the raw materials to the maximum extent, and has a complete structure and high extraction rate.
In some examples, step S40 is further included before the step of mixing the donkey-hide gelatin and saussurea involucrate culture with the extract obtained in step S30.
Step S40: the extract liquid obtained in step S30 is subjected to solid-liquid separation to obtain a liquid phase, and the liquid phase is concentrated.
In some examples, in step S40, the extract obtained in step S30 is centrifuged and filtered to separate solid from liquid. In particular, filtration may be achieved in the form of microfiltration.
In some examples, in step S40, the rotating speed is 3800 r/min-7000 r/min; preferably, the rotation speed is 5000 r/min.
It is understood that the extraction step and the centrifugation step are performed sequentially, and the extraction and centrifugation may be performed a plurality of times, and the centrifugate obtained a plurality of times may be mixed.
In some examples, in step S40, the filter pore size is 400nm to 600 nm.
In some examples, in step S40, the filter membrane used is a ceramic membrane, and the microfiltration temperature is ≦ 40 ℃.
In some examples, in the filtering step in step S40, the feed pump frequency is 25Hz to 50Hz, the circulation pump frequency is 25Hz to 50Hz, the membrane tube pressure is 0.1MPa to 0.20MPa, and the clear liquid end flow rate is 0.5L/min to 2L/min; preferably, the frequency of the feeding pump and the frequency of the circulating pump are both 50Hz, the pressure of the membrane tube is 0.1MPa, and the flow rate of the clear liquid end is 0.75L/min.
In some examples, in step S40, the filtrate obtained by the solid-liquid separation is subjected to membrane concentration (reverse osmosis concentration) to obtain a membrane concentrate.
In some examples, in step S40, the reverse osmosis membrane used is an organic membrane, and the reverse osmosis temperature is 30 ℃ or less.
In some examples, in the membrane concentration step in step S40, the feed pump frequency is 0Hz to 50Hz, the circulation pump frequency is 0Hz to 50Hz, the membrane tube pressure is 0MPa to 2.0MPa, and the clear liquid end flow rate is 0.5L/min to 4L/min; preferably, the frequency of the feeding pump and the frequency of the circulating pump are both 50Hz, the pressure of the membrane tube is 0.5MPa, and the flow rate of the clear liquid end is 1.5L/min.
In some examples, in step S40, the membrane concentrated solution obtained in the membrane concentration step is vacuum concentrated to obtain a vacuum concentrated solution.
In some examples, in step S40, vacuum concentration is performed to a solids content of 30% to 40%. It can be understood that when the solid content is 30-40% by vacuum concentration, the preparation is made for vacuum drying in the subsequent process, and the vacuum drying time is shortened.
In some examples, in step S40, the vacuum concentration temperature is 60 ℃ to 80 ℃; preferably, the vacuum concentration temperature is 80 ℃.
It is understood that, in some examples, in step S50, the donkey-hide gelatin and saussurea involucrate culture are mixed with the vacuum concentrated solution prepared in step S40 to obtain a steamed solution.
Further, in some examples, the method for preparing a plant beverage further includes step S60 after the blending step in step S50.
S60: and (4) uniformly mixing the extraction solution prepared in the step S50 with auxiliary materials, drying and sieving to obtain the plant beverage.
It is understood that, in some examples, in step S60, the steaming solution prepared in step S50 is mixed with auxiliary materials, dried and sieved to obtain the plant solid beverage.
In some examples, in step S60, the distilled solution prepared in step S50 is placed in a universal clean zone and then mixed with the auxiliary materials.
In some examples, the drying in step S60 is performed under vacuum conditions at a drying temperature of 60 ℃ to 80 ℃.
In some examples, in step S60, the mesh number of the screen used for sieving is 10-30 meshes; preferably, the mesh number of the screen is 20 meshes.
The plant solid beverage for regulating female endocrine is obtained by the combined processes of high pressure difference extraction, centrifugation, microfiltration, concentration, drying, sieving and the like, can effectively regulate female endocrine and maintain ovary, and has good taste, convenient carrying, environmental protection, safety and harmlessness.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
Hereinafter, the use of the endocrine-regulating composition according to the present invention in a plant solid drink is exemplified, and it is understood that the endocrine-regulating composition and the use thereof are not limited to the following examples.
Example 1
The formula of the plant solid beverage comprises the following components:
35 parts of truffle, 20 parts of agaricus blazei, 8 parts of longan pulp, 4 parts of emblic leafflower fruit, 2 parts of donkey-hide gelatin, 1 part of sophora flower bud and 0.01 part of saussurea involucrate culture.
Referring to the attached figure 1, the preparation method of the plant solid beverage comprises the following steps:
weighing: weighing the raw materials in proportion.
Crushing: wet pulverizing truffle, Agaricus blazei Murill, arillus longan, fructus Phyllanthi and flos Sophorae Immaturus with universal pulverizer with aperture of 1.22mm to obtain fine powder 1; dissolving colla Corii Asini in hot water to obtain hot solution 1; the saussurea involucrate culture is powdery without a crushing process.
③ extracting for the first time: and (3) adding purified water in 17 times of the fine crushed product 1 by adopting a continuous extraction separation concentrator (HHLSE) for low-temperature instantaneous extraction, wherein the extraction flow rate is 0.9L/min, the extraction temperature is 25 +/-1 ℃, and the extraction pressure is 25 +/-5 MPa, so as to obtain an extracting solution 1.
Fourthly, first centrifugation: centrifuging (5000r/min) the extracting solution 1 obtained in the step (c) to obtain a centrifugate 1.
Extracting for the second time: and d, supplementing 14 times of purified water to the centrifugal residues 1 in the step (iv), and performing secondary extraction according to the extraction method in the step (iii) to obtain an extracting solution 2.
Sixthly, centrifuging for the second time: centrifuging the extracting solution 2 obtained in the fifth step, and performing secondary centrifugation according to the centrifugation method of the fourth step to obtain a centrifugate 2.
And (c) microfiltration and concentration: and (4) sequentially carrying out microfiltration and reverse osmosis concentration on the centrifugate obtained in the step (iv) and the centrifugate obtained in the step (iv).
Wherein, the microfiltration of the filter membrane is (500nm) (the temperature is less than or equal to 40 ℃, the temperature of the ceramic membrane), the frequency of the feeding pump and the circulating pump is 50Hz, the pressure of the membrane tube is 0.1MPa, and the flow rate of the clear liquid end is 0.75L/min;
concentrating by reverse osmosis (no more than 30 deg.C, organic membrane), feeding pump and circulating pump frequency 50Hz, membrane tube pressure 0.5MPa, clear liquid end flow rate 1.5L/min, vacuum concentrating (80 deg.C), adding colla Corii Asini hot solution and herba Saussureae Involueratae culture into vacuum concentrated solution according to formula ratio, and mixing to obtain truffle compound concentrated solution.
And (b) vacuum drying: and (4) putting the compound truffle concentrated solution in the step (c) into a universal clean area, adding a proper amount of auxiliary materials (7.96 parts of maltodextrin), and performing vacuum drying (80 ℃) to obtain a compound truffle vacuum dried product.
Ninthly, sieving: and (6) sieving the truffle compound vacuum dried product obtained in the step (V) through a 20-mesh sieve to obtain the endocrine regulating plant solid beverage.
Example 2
The formulation composition and the preparation method of the plant solid beverage are basically the same as those of the plant solid beverage in example 1, and only the proportion in the formulation composition is different, and the specific ratio is as follows:
37 parts of truffle, 18 parts of agaricus blazei, 10 parts of longan pulp, 3 parts of emblic leafflower fruit, 1 part of donkey-hide gelatin, 1 part of sophora flower bud and 0.01 part of saussurea involucrate culture.
Example 3
The formulation composition and the preparation method of the plant solid beverage are basically the same as those of the plant solid beverage in example 1, and only the proportion in the formulation composition is different, and the specific ratio is as follows:
30 parts of truffle, 25 parts of agaricus blazei, 5 parts of longan pulp, 6 parts of emblic leafflower fruit, 4 parts of donkey-hide gelatin, 2 parts of sophora flower bud and 0.02 part of saussurea involucrate culture.
Comparative example 1
The formulation composition and the preparation method of the plant solid beverage are basically the same as those of the plant solid beverage in example 1, and only the proportion in the formulation composition is different, and the specific ratio is as follows:
45 parts of truffle, 10 parts of agaricus blazei, 1 part of longan pulp, 4 parts of emblic leafflower fruit, 5 parts of donkey-hide gelatin, 5 parts of sophora flower bud and 1 part of saussurea involucrate culture.
Comparative example 2
The formula composition and the preparation method of the plant solid beverage are basically the same as those of the plant solid beverage in the example 1, and only the saussurea involucrate culture is not contained, and the formula composition and the preparation method are as follows:
35 parts of truffle, 20 parts of agaricus blazei murill, 8 parts of longan pulp, 4 parts of emblic leafflower fruit, 2 parts of donkey-hide gelatin and 1 part of sophora flower bud.
Comparative example 3
The formula composition and the preparation method of the plant solid beverage are basically the same as those of the plant solid beverage in the example 1, and the truffle is replaced by morchella of the same quality, which is as follows:
35 parts of morel, 20 parts of agaricus blazei, 8 parts of longan pulp, 4 parts of emblic leafflower fruit, 2 parts of donkey-hide gelatin, 1 part of sophora flower bud and 0.01 part of saussurea involucrate culture.
Comparative example 4
The formulation and the preparation method of the plant solid beverage are basically the same as those of the plant solid beverage in the example 1, and only the agaricus blazei murill is replaced by hericium erinaceus with equal mass, which is concretely as follows:
35 parts of truffle, 20 parts of hericium erinaceus, 8 parts of longan pulp, 4 parts of emblic leafflower fruit, 2 parts of donkey-hide gelatin, 1 part of sophora flower bud and 0.01 part of saussurea involucrate culture.
Study of efficacy
In order to verify the clinical effect of the product, clinical experiments were performed, and the specific experimental procedures were as follows:
(1) test object
560 cases of female patients with endocrine dyscrasia were randomly selected, the age distribution was 30-50 years, and the patients were randomly divided into 7 groups of 80 patients.
(2) Method of administration
The endocrine regulating plant solid beverage prepared in the examples 1-3 and the comparative examples 1-4 is taken by each group 2 times a day with 1 bag, 2 g/bag and 120-150 mL warm water each time, and is taken on empty stomach, one month is a treatment course, and the period of taking is 2-3 months.
(3) Diagnostic criteria for therapeutic effect
And (3) curing: the facial color spot disappears, the skin becomes ruddy and glossy, the irregular menstruation, the dysphoria and other clinical symptoms disappear, and objective inspection indexes (follicle stimulating hormone, luteinizing hormone, estrogen, progestogen, prolactin and testosterone hormone) are normal.
The method has the following advantages: the facial color spot is lightened, the skin glossiness is increased, the irregular menstruation, the dysphoria and other clinical symptoms are relieved, and objective inspection indexes (follicle stimulating hormone, luteinizing hormone, estrogen, progestogen, prolactin and testosterone hormone) are improved.
And (4) invalidation: clinical symptoms such as facial color spots, skin glossiness, irregular menstruation, ovarian mature follicles and the like are not improved, and objective examination indexes (follicle stimulating hormone, luteinizing hormone, estrogen, progestogen, prolactin and testosterone hormone) are not improved.
(4) Therapeutic results
The results of a study of the efficacy of 560 randomly selected female patients with endocrine dyscrasia are shown in table 1:
TABLE 1
Figure BDA0002979984520000161
Figure BDA0002979984520000171
As can be seen from Table 1, the significant efficiency of examples 1-3 is more than 93.5%, and the significant efficiency of comparative examples 1-4 is lower, which shows that the plant solid beverage for regulating female endocrine and maintaining ovary composition prepared by the invention has obvious effects on regulating endocrine disturbance and menstrual disorder, improving skin color and luster and objectively inspecting indexes.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (10)

1. An endocrine regulating composition comprises the following components in parts by weight:
Figure FDA0002979984510000011
2. the endocrine regulating composition according to claim 1, comprising the following components in parts by weight:
Figure FDA0002979984510000012
3. the endocrine regulating composition according to claim 2, comprising the following components in parts by weight:
Figure FDA0002979984510000013
Figure FDA0002979984510000021
4. the use of the endocrine regulating composition according to any one of claims 1 to 3 in the preparation of a medicament or health product or drink for regulating female endocrine and maintaining ovary.
5. A plant beverage comprising the endocrine regulating composition according to any one of claims 1 to 3.
6. The plant beverage according to claim 5, further comprising an adjuvant selected from at least one of maltodextrin, starch, β -cyclodextrin and gum arabic.
7. A preparation method of a vegetable beverage for regulating female endocrine is characterized by comprising the following steps:
1) weighing the raw materials in the endocrine regulating composition as defined in any one of claims 1 to 3;
2) extracting the truffle, the agaricus blazei murill, the longan pulp, the emblic leafflower fruit and the sophora flower bud to obtain an extracting solution;
3) and uniformly mixing the extracting solution with the donkey-hide gelatin and the saussurea involucrate culture to obtain the plant beverage.
8. The method for preparing a plant beverage according to claim 7, wherein the step of mixing the extract with the donkey-hide gelatin and the saussurea involucrate culture is preceded by a step of performing solid-liquid separation on the extract to obtain a liquid phase and concentrating the liquid phase.
9. The method for preparing a plant beverage according to claim 7 or 8, wherein after the blending step in step 3), the method further comprises the steps of adding auxiliary materials into the blended mixture, drying and sieving to obtain the plant solid beverage.
10. The method for preparing a vegetable beverage according to claim 7 or 8, characterized in that the extraction conditions are: the extraction temperature is 20-30 ℃, the extraction pressure is 20-60 Mpa, and the extraction flow rate is 0.5-1.5L/min.
CN202110284763.3A 2021-03-17 2021-03-17 Endocrine regulating composition, application thereof and plant beverage Pending CN112843122A (en)

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