CN112842934A - Long-acting moisturizing lip balm containing phosphorylcholine polymer and preparation method thereof - Google Patents

Abstract

The invention discloses a long-acting moisturizing lip balm containing phosphorylcholine polymer and a preparation method thereof. The formula of the lip balm comprises the following components in parts by weight: 10 to 30 portions of vegetable oil, 10 to 16 portions of wax, 50 to 75 portions of ester, 0.50 to 5 portions of antioxidant and 0.1 to 10 portions of phosphorylcholine oil solution. Different from the traditional lipstick, the phosphorylcholine added in the invention can keep moisture and nourish for a long time, moisten and luster, and has good moisture-keeping effect.

Description

Long-acting moisturizing lip balm containing phosphorylcholine polymer and preparation method thereof

Technical Field

The invention relates to the field of cosmetic raw materials, in particular to a long-acting moisturizing lip balm containing phosphorylcholine polymer and a preparation method thereof.

Background

In daily skin care, lips are easily ignored parts, the skin of the lips is different from the skin of other parts, the cutin of the skin of the lips is thin, hair follicles and sebaceous glands are not contained, and the lips are exposed outside and are particularly easy to dry, and are easy to crack and bleed. The image and the smell of people are influenced to a certain extent, so that the lips need skin care products capable of permanently moistening and preserving moisture, and a protective barrier is provided for the lips.

The lip balm is a commonly used lip skin care product and mainly comprises a wax base and grease, most of the raw materials of the lip balm sold on the market at present contain mineral oil petrolatum, synthetic wax, synthetic grease and the like, but the active ingredients of the mineral oil petrolatum and the like are easy to run off midway, so that the effect of long-term moistening is difficult to provide.

Therefore, there is an urgent need in the art to develop a novel lip balm capable of moisturizing for a long time to provide long-lasting moisturizing effect to the lips.

Disclosure of Invention

The invention aims to provide a novel lip balm capable of preserving moisture for a long time, and the lip balm can provide long-term moisturizing effect for lips. Specifically, the invention provides a lipstick containing phosphorylcholine oil solution, which provides long-term moisturizing effect for lips.

In a first aspect of the invention, there is provided a composition comprising: 10 to 30 portions of vegetable oil, 10 to 16 portions of wax, 50 to 75 portions of ester, 0.50 to 5 portions of antioxidant and 0.1 to 10 portions of phosphorylcholine oil solution.

In another preferred embodiment, the phosphorylcholine polymer oil solution comprises, based on the total weight of the oil solution: 0.1-10% of phosphorylcholine polymer, 5-50% of emulsifier and 5-50% of grease.

In another preferred embodiment, the phosphorylcholine polymer contains (a) hydrophilic groups; (b) a hydrophobic group.

In another preferred embodiment, the hydrophilic group has a branched structure represented by formula I:

in the formula, R₁，R₂And R₃Each independently selected from: H. c₁-C₄Alkyl radical, C₃-C₄A cycloalkyl group of (a).

In another preferred embodiment, the backbone unit of the phosphorylcholine polymer is selected from the group consisting of:

A1)

A2)

A3)

A4)

A5) A1-A4 combination.

In another preferred example, in A1-A5, the phosphorylcholine group represented by formula I is represented by-CO-O-CH₂-CH₂-、-CO-O-CH₂-CH₂-O-, and/or-CO-O- (CH)₂)m-CH₂-linked to the main chain, wherein m is a positive integer from 2 to 17.

In another preferred embodiment, the backbone is selected from the group consisting of:

in another preferred embodiment, the phosphorylcholine polymer is selected from: 2-methacryloyloxyethyl phosphorylcholine homopolymers, copolymers of 2-methacryloyloxyethyl phosphorylcholine and other hydrophilic and/or hydrophobic monomers or combinations thereof, polyphosphocholine ethylene glycol acrylate, polyphosphocholine n-butyl methacrylate, or combinations thereof.

In another preferred embodiment, the grease is selected from: isopropyl palmitate, isooctyl palmitate, isononyl isononanoate, white oil, glyceryl caprylate/caprate triester, octyldodecanol, coconut oil acid, lauryl alcohol, isopropyl myristate, shea butter, isooctyl 12-hydroxystearate, diisostearyl malate, squalane, jojoba oil, soybean oil, olive oil, sweet almond oil, avocado oil, wheat germ oil, or combinations thereof.

In another preferred embodiment, the emulsifier is selected from the group consisting of: polyglycerol esters, sorbitan fatty acid ester series, sorbitol cocoate, sucrose fatty acid ester, alkyl glycosides, hydrogenated lecithin, fatty alcohol polyoxyethylene ether, alkylphenol ethoxylates, fatty acid polyoxyethylene esters, polyethers, glyceryl caprylic/capric acid esters, or combinations thereof.

In another preferred embodiment, the vegetable oil is selected from: squalane, jojoba oil, soybean oil, olive oil, sweet almond oil, avocado oil, wheat germ oil, coconut oil, shea butter.

In another preferred embodiment, the wax is selected from: beeswax, candelilla wax, carnauba wax, microcrystalline wax, ozokerite wax, polyethylene.

In another preferred embodiment, the esters are selected from: isopropyl palmitate, isooctyl palmitate, isononyl isononanoate, caprylic/capric glycerides, hydrogenated coconut oil glycerides, polyglycerol esters, hydrogenated castor oil isostearate, octyldodecanol.

In a second aspect of the invention, there is provided the use of a composition according to the first aspect for the preparation of a lip balm.

In a third aspect of the invention, there is provided a lip balm comprising the composition of the first aspect.

In a fourth aspect of the present invention, there is provided a method of preparing the lip balm of the third aspect, comprising the steps of:

s1) mixing vegetable oil, wax and lipid according to a certain proportion, and heating to T0 temperature;

s2) reducing the oil phase in step S1 to a temperature T1 to obtain a first oil phase;

s3) mixing the first oil phase with a phosphorylcholine polymer oil solution with the temperature of T2 and an antioxidant, stirring, and cooling for a period of time T0 to obtain the lip balm.

In another preferred embodiment, said T0 is 90-100 ℃.

In another preferred embodiment, said T1 is 50-70 ℃.

In another preferred embodiment, the T2 is <80 deg.c

In another preferred embodiment, said T0 is 90-100 ℃.

It is to be understood that within the scope of the present invention, the above-described features of the present invention and those specifically described below (e.g., in the examples) may be combined with each other to form new or preferred embodiments. Not to be reiterated herein, but to the extent of space.

Drawings

FIG. 1 shows an outer package of a lipstick containing a phosphorylcholine polymer prepared according to one embodiment of the present invention.

Figure 2 shows the appearance of a lip balm containing a phosphorylcholine polymer prepared according to one embodiment of the present invention.

Figure 3 illustrates a top view of a lipstick containing a phosphorylcholine polymer made according to one embodiment of the present invention.

FIG. 4 shows the change in skin moisture content after the application of lipstick in the 0.1% phosphorylcholine polymer (PQ-51) group, the 0.1% hyaluronan group, and the blank group without PQ-51 and hyaluronan.

FIG. 5 shows the change in skin water loss after lipstick application for the 0.1% phosphorylcholine polymer (PQ-51) group, the 0.1% hyaluronan group, and the blank group without PQ-51 and hyaluronan.

Detailed Description

The inventor of the invention has made extensive and intensive studies, and surprisingly found a lipstick formula capable of moisturizing for a long time for the first time through a large number of screens, and the invention has been completed on the basis of the finding.

Specifically, the invention provides a lipstick containing phosphorylcholine oil solution, which can form a breathable biological membrane on the surface of skin to form a breathable water-retention film and has a molecular nail effect, namely the breathable biological membrane is still kept on the surface of the skin after being washed with water for many times, so that the lipstick can retain moisture for a long time and reduce irritation.

Term(s) for

As used herein, "lipstick of the present invention", "lipstick containing phosphorylcholine polymer of the present invention" are used interchangeably and refer to a lipstick having a long lasting moisturizing effect prepared according to the methods and formulations of the present invention.

Phosphorylcholine polymer compound

In the oily stock solution of the present invention, one core component is a phosphorylcholine polymer.

In the present invention, the phosphorylcholine polymer refers to a polymer containing a phosphorylcholine group, particularly a polymer having a phosphorylcholine group in a side chain. The phosphorylcholine polymers of the present invention may be homopolymers or copolymers, including random copolymers, block copolymers, or combinations thereof. The copolymers of the invention may be binary, ternary or higher order copolymers.

In the present invention, the phosphorylcholine group may be directly linked (e.g., terminated) to a polymer backbone (backbone) or indirectly linked to the backbone via a linking group (e.g., a divalent linking group, or a divalent linking group).

In addition, in the present invention, the preferred phosphorylcholine polymer further contains a hydrophobic group, for example, a hydrophobic group at a side chain, or a hydrophobic group at a terminal.

Preferably, the phosphorylcholine polymers of the invention are copolymers formed, for example, by copolymerization of monomers containing phosphorylcholine groups with monomers containing no phosphorylcholine groups.

In another preferred embodiment, the phosphorylcholine polymer of the present invention is a polymer formed by polymerization of a hydrophobic monomer (monomer not containing a phosphorylcholine group) and a hydrophilic monomer (monomer containing a phosphorylcholine group).

The phosphorylcholine polymer of the present invention can be prepared by a known method, or can be obtained commercially. In addition, the phosphorylcholine polymer of the present invention also includes a phosphorylcholine polymer prepared by modifying a polymer.

Preferably, the phosphorylcholine polymer of the invention contains phosphorylcholine groups (preferably as groups on a branch) of formula I:

in the formula, R₁、R₂And R₃Each independently selected from: H. c₁-C₄Alkyl of (A), C₃-C₄Cycloalkyl groups of (a);

n is 1,2, 3, or 4.

Preferably, R₁、R₂And R₃Each independently selected from: H. methyl or ethyl.

Preferably, n is 2 or 3.

In another preferred example, the molecular weight of the phosphorylcholine polymer is not particularly limited, and a preferred weight-average molecular weight or number-average molecular weight is 1 to 300 ten thousand, more preferably 5 to 200 ten thousand.

In another preferred embodiment, examples of the phosphorylcholine polymer include (but are not limited to): 2-methacryloyloxyethyl phosphorylcholine homopolymer, copolymer of 2-methacryloyloxyethyl phosphorylcholine and other hydrophilic and/or hydrophobic monomers or combination thereof, polyphosphoric acid choline ethylene glycol acrylate, polyphosphoric acid choline n-butyl methacrylate.

The inventors of the present invention have unexpectedly found that when a specific emulsifier is used, the solubility of an oil-insoluble phosphorylcholine polymer can be significantly improved, and the oil-insoluble phosphorylcholine polymer can be well dissolved and dispersed in an oil or an oily solvent, so that the oil solution of a phosphorylcholine polymer (an oily stock solution containing a high-concentration phosphorylcholine polymer compound) of the present invention has high transparency, and has excellent characteristics of higher stability, higher biocompatibility, and the like, thereby significantly increasing the content of the phosphorylcholine polymer in cosmetics made from the oil solution of a phosphorylcholine polymer, increasing the permeability of the phosphorylcholine polymer, and enhancing the effects or efficacies of moisturizing repair, and the like of the phosphorylcholine polymer.

Other ingredients

In the oily stock solution of the present invention, one or more additional ingredients may be further added as long as the additional ingredients do not substantially affect the oily stock solution of the present invention (e.g., cause a significant decrease in the solubility of the phosphorylcholine polymer, cause opacity, etc.).

These additional ingredients are optional, and representative additional ingredients include (but are not limited to): preservatives, perfumes, antioxidants, pigments (e.g. natural pigments), fragrances, or other cosmetically acceptable active ingredients (e.g. ceramides) or adjuvants.

For example, a fragrance may be added to the oily stock solution of the present invention to obtain a predetermined fragrance.

Preservatives may be added to the oily stock solutions of the present invention to further achieve long-term shelf life performance. Representative preservatives are selected from: phenoxyethanol, methyl benzoate, sorbic acids, 1, 3-butanediol, 1, 2-pentanediol, 1, 2-hexanediol, or combinations thereof.

The antioxidant is selected from: tocopherol, tocopherol acetate, tocopherol succinate, a tocopherol mixture, or a mixture thereof.

Preparation method

The invention also provides a method of making the lipstick of the invention.

In a preferred embodiment, the method comprises the steps of:

(1) adding vegetable oil, wax and esters at a certain ratio, and heating to 90-100 deg.C to transparent;

(2) cooling the oil phase in the step (1) to 50-70 ℃, adding an oil solution with phosphorylcholine content of 1-8%, and adding an antioxidant; it is noted that the temperature at which phosphorylcholine is added should not be too high.

(3) The mixture is stirred evenly, cooled and canned to obtain the product.

The main advantages of the invention include:

(a) the phosphorylcholine polymer is successfully added into a lipstick formula by utilizing the intelligent water locking and molecular nail effects of the phosphorylcholine polymer, so that the lip moisturizing effect is achieved for a long time.

The invention will be further illustrated with reference to the following specific examples. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. The experimental procedures, in which specific conditions are not noted in the following examples, are generally carried out under conventional conditions or conditions recommended by the manufacturers. Unless otherwise indicated, percentages and parts are percentages and parts by weight.

Example 1 preparation of Long-lasting lip gloss No.1

Weighing the components according to the raw material proportion shown in the example 1 of the table 1, and then operating according to the following steps:

(1) adding vegetable oil, synthetic wax and synthetic ester at a certain ratio, and heating to 90-100 deg.C to transparent;

(2) cooling the oil phase in the step (1) to 50-70 ℃, adding an oil solution with phosphorylcholine content of 1-8%, and adding an antioxidant; it is noted that the temperature at which phosphorylcholine is added should not be too high.

(3) The mixture is stirred evenly, cooled and canned to obtain the product.

Table 1 raw material formulation (weight percent)

Example 2 preparation of Long-lasting lip gloss No.2

Example 1 was repeated except that the ingredients were weighed in the proportions shown in Table 1 for the raw materials of example 2 to obtain lip gloss No.2 having a long lasting moisturizing effect.

Comparative example 1 preparation of comparative lip gloss No.3

Example 1 was repeated except that the components were weighed in accordance with the raw material ratios of comparative example 1 shown in Table 1 to obtain long-lasting lip gloss No. 3.

Example 3 Performance testing

3.1 physical and chemical indexes

The lipstick prepared in the embodiment 1 of the invention is wax-like as shown in fig. 1,2 and 3, has white to light yellow appearance, good coating property, moderate hardness, and moisturizing and comfortable feeling.

3.2 Heat and Cold resistance test

The lip gloss cans prepared in examples 1-2 and comparative example 1 were packed in a package, and the temperature of the refrigerator was previously adjusted to 0 ℃ to-18 ℃ and the sample was placed in the refrigerator. And taking out after 24h, recovering to room temperature, smearing a small amount of the sample on the back of the hand, observing the service performance by visual observation, using the sample normally, and continuously testing for about 2 months to observe the phenomenon of no sweating and no odor. Keeping the temperature at 45 +/-1 ℃ for 24 hours, and after the temperature is restored to the room temperature, no sweating phenomenon exists; the paste is observed for about 2 months without layering, sweating, off-flavor and the like.

4.3 Room temperature standing experiment

The long-acting moisturizing and nourishing lip balms prepared in the examples 1-2 and the comparative example 1 are placed in a packaging material, and the lip balms are kept still at room temperature for 2 months, so that the appearance of the lip balms is free from sweating and softening, the smell of the lip balms is also unchanged, and the feeling of the lip balms after being applied is not obviously changed.

The physical and chemical properties, cold and heat resistance, and room temperature storage of the lipsticks prepared in examples 1 to 2 and comparative example 1 are summarized in the following table 2:

TABLE 2 physical indexes, cold and heat resistance, and standing at room temperature of examples 1 to 2, comparative example 1

4.4 moisturizing Effect test

Three sets of experiments were set up: a blank containing 0.1% phosphorylcholine polymer (PQ-51), 0.1% hyaluronan, and no PQ-51 and hyaluronan. The lipstick prepared by the three formulations was applied to the skin, and the change rate of the skin moisture content and the change rate of the skin moisture loss of the different treatment groups were measured by a CK MPA 580 multifunctional skin tester, and the results are shown in fig. 4.

As can be seen from FIG. 4, when the blank group containing 0.1% phosphorylcholine polymer (PQ-51), 0.1% hyaluronan and no PQ-51 and hyaluronan were compared for 7 hours, the moisture content of the 0.1% PQ-51 group was 14.46%, the moisture content of the 0.1% hyaluronan group was 7.38%, and the blank group was lower.

The skin treated with the blank group containing 0.1% phosphorylcholine polymer (PQ-51), 0.1% hyaluronan, and no PQ-51 and hyaluronan was also subjected to the water loss change rate test, and the results are shown in fig. 5.

As can be seen in FIG. 5, the group containing 0.1% phosphorylcholine polymer (PQ-51) showed the least change in the rate of change in the transdermal water loss and the least water loss, the second 0.1% hyaluronan and the fastest loss in the blank group.

Therefore, by comparing the change rate of the skin moisture content and the change rate of the percutaneous water loss of different treatment groups, it can be seen that the lip balm containing the phosphorylcholine (PQ-51) oil solution can help the skin to keep moisture for a long time, and is an ideal raw material for the lip balm.

Discussion of the related Art

The phosphorylcholine polymer serving as a bionic biomaterial with good biocompatibility has high biocompatibility, is mainly applied to the fields of biomedicine and medical instruments, and is already used as a moisturizing raw material in high-grade cosmetics. The polyquaternium-51 is one of phosphorylcholine polymers, can form a breathable biological membrane on the surface of skin to form a breathable water-retention film, has a molecular nail effect, namely remains on the surface of the skin after being washed by water for many times, and has long-term moisture retention and reduced irritation. The lipstick has super-strong intelligent water-locking and moisture-keeping performance which is twice that of hyaluronic acid, inhibits the stimulation of irritants in a finished product to skin, shields dust in the environment, adsorbs a stable charge layer, eliminates static electricity, and is an ideal raw material for the lipstick.

Therefore, compared with the lipstick prepared by the prior art, the lipstick prepared by the formula provided by the invention can effectively preserve moisture, slow down the rate of water loss and achieve the effect of preserving moisture for a long time.

All documents referred to herein are incorporated by reference into this application as if each were individually incorporated by reference. Furthermore, it should be understood that various changes and modifications of the present invention can be made by those skilled in the art after reading the above teachings of the present invention, and these equivalents also fall within the scope of the present invention as defined by the appended claims.

Claims (10)

1. A composition, said composition comprising: 10 to 30 portions of vegetable oil, 10 to 16 portions of wax, 50 to 75 portions of ester, 0.50 to 5 portions of antioxidant and 0.1 to 10 portions of phosphorylcholine oil solution.

2. The composition of claim 1, wherein the phosphorylcholine polymer oil solution comprises, based on the total weight of the oil solution: 0.1-10% of phosphorylcholine polymer, 5-50% of emulsifier and 5-50% of grease.

3. The composition of claim 2, wherein the phosphorylcholine polymer comprises (a) hydrophilic groups; (b) a hydrophobic group.

4. The composition of claim 3, wherein the hydrophilic group comprises a branched structure of formula I:

in the formula, R₁，R₂And R₃Each independently selected from: H. c₁-C₄Alkyl radical, C₃-C₄A cycloalkyl group of (a).

5. The composition of claim 1, wherein the vegetable oil is selected from the group consisting of: squalane, jojoba oil, soybean oil, olive oil, sweet almond oil, avocado oil, wheat germ oil, coconut oil, shea butter.

6. The composition of claim 1, wherein the wax is selected from the group consisting of: beeswax, candelilla wax, carnauba wax, microcrystalline wax, ozokerite wax, polyethylene.

7. The composition of claim 1, wherein the ester is selected from the group consisting of: isopropyl palmitate, isooctyl palmitate, isononyl isononanoate, caprylic/capric glycerides, hydrogenated coconut oil glycerides, polyglycerol esters, hydrogenated castor oil isostearate, octyldodecanol.

8. Use of a composition according to claim 1 for the preparation of a lip balm.

9. A lip balm comprising the composition of claim 1.

10. A method of making the lip balm of claim 6, comprising the steps of:

s1) mixing vegetable oil, wax and esters according to a certain proportion, and heating to T0 temperature;

s2) reducing the oil phase in step S1 to a temperature T1 to obtain a first oil phase;

s3) mixing the first oil phase with a phosphorylcholine polymer oil solution with the temperature of T2 and an antioxidant, stirring, and cooling for a period of time T0 to obtain the lip balm.

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