CN112839512B - 用于供体器官上的碳水化合物抗原切割的酶促组合物、与其相关的方法和用途 - Google Patents

用于供体器官上的碳水化合物抗原切割的酶促组合物、与其相关的方法和用途 Download PDF

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CN112839512B
CN112839512B CN201980067904.7A CN201980067904A CN112839512B CN 112839512 B CN112839512 B CN 112839512B CN 201980067904 A CN201980067904 A CN 201980067904A CN 112839512 B CN112839512 B CN 112839512B
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CN112839512A (zh
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马塞洛·塞普拉
王艾舟
沙菲克·克沙夫吉
斯蒂芬·G·威瑟斯
彼得·拉费尔德
加雅善德兰·基萨科达特胡
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University of British Columbia
University Health Network
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University Health Network
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
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    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
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    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
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    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01049—Alpha-N-acetylgalactosaminidase (3.2.1.49)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01025—N-Acetylglucosamine-6-phosphate deacetylase (3.5.1.25)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
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CN201980067904.7A 2018-08-17 2019-08-16 用于供体器官上的碳水化合物抗原切割的酶促组合物、与其相关的方法和用途 Active CN112839512B (zh)

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CN202310572735.0A CN117044707A (zh) 2018-08-17 2019-08-16 用于供体器官上的碳水化合物抗原切割的酶促组合物、与其相关的方法和用途

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US201862719272P 2018-08-17 2018-08-17
US62/719,272 2018-08-17
PCT/CA2019/051121 WO2020034043A1 (en) 2018-08-17 2019-08-16 Enzymatic compositions for carbohydrate antigen cleavage on donor organs, methods and uses associated therewith

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CN202310572735.0A Pending CN117044707A (zh) 2018-08-17 2019-08-16 用于供体器官上的碳水化合物抗原切割的酶促组合物、与其相关的方法和用途
CN202411828074.4A Pending CN119662602A (zh) 2018-08-17 2019-08-16 用于碳水化合物抗原切割的酶促组合物，与其相关的方法、用途、设备和系统
CN201980067913.6A Active CN112840027B (zh) 2018-08-17 2019-08-16 用于碳水化合物抗原切割的酶促组合物，与其相关的方法、用途、设备和系统

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CN202411828074.4A Pending CN119662602A (zh) 2018-08-17 2019-08-16 用于碳水化合物抗原切割的酶促组合物，与其相关的方法、用途、设备和系统
CN201980067913.6A Active CN112840027B (zh) 2018-08-17 2019-08-16 用于碳水化合物抗原切割的酶促组合物，与其相关的方法、用途、设备和系统

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US (4) US20210324361A1 (https=)
EP (2) EP3837370A4 (https=)
JP (4) JP7684216B2 (https=)
CN (4) CN112839512B (https=)
AU (1) AU2019322933B2 (https=)
BR (1) BR112021002899A2 (https=)
CA (2) CA3109723A1 (https=)
WO (2) WO2020034043A1 (https=)

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CN116024183B (zh) * 2023-02-15 2023-10-31 中国农业科学院兰州兽医研究所 一种用于荧光染色的重组蓝舌病毒及其构建方法
WO2025213250A1 (en) * 2024-04-11 2025-10-16 The University Of British Columbia Enzymatic compositions for b antigen cleavage, methods, uses, apparatuses and systems associated therewith
JP2026057100A (ja) 2024-09-20 2026-04-02 トヨタ自動車株式会社 電気ユニット

Citations (2)

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WO2003027245A2 (en) * 2001-09-25 2003-04-03 Zymequest, Inc. CONVERSION OF RED BLOOD CELLS A, B, AND AB USING a-N-ACETYLGALACTOSAMINIDASES AND a-GALACTOSIDASE
WO2007100294A1 (en) * 2006-02-28 2007-09-07 Kurt Nilsson Material system for blood products

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US4609627A (en) * 1983-08-01 1986-09-02 New York Blood Center, Inc. Enzymatic conversion of certain sub-type A and AB erythrocytes
CA2272925A1 (en) * 1996-11-21 1998-05-28 Jack Goldstein Method for conversion of blood type
WO2007053565A2 (en) 2005-10-31 2007-05-10 Zymequest, Inc. Novel a-galactosidases
CA2697999C (en) * 2009-04-24 2013-04-30 Werner Hoelke A stabilized aqueous alpha-galactosidase composition and methods relating thereto
JP6336392B2 (ja) 2012-09-08 2018-06-06 株式会社オーガンテクノロジーズ 移植のための臓器又は組織の長期維持方法
CA2920293A1 (en) 2013-08-16 2015-02-19 Alexion Pharmaceuticals, Inc. Treatment of graft rejection by administering a complement inhibitor to an organ prior to transplant
CN107298699B (zh) * 2017-07-21 2020-09-11 天津大学 通过添加大分子拥挤试剂高效体外生物生产蛋白质的配方及方法
EP3962295A1 (en) * 2019-05-01 2022-03-09 The Procter & Gamble Company Probiotic bacterial strains that produce short chain fatty acids and compositions comprising same

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2003027245A2 (en) * 2001-09-25 2003-04-03 Zymequest, Inc. CONVERSION OF RED BLOOD CELLS A, B, AND AB USING a-N-ACETYLGALACTOSAMINIDASES AND a-GALACTOSIDASE
WO2007100294A1 (en) * 2006-02-28 2007-09-07 Kurt Nilsson Material system for blood products

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Development of H-Specificity in A Substance by A-Decomposing Enzyme Clostridium tertium A;YAMAMOTO, H. 等;《Proceedings ofthe Japan Academy》;19680412;第44卷(第4期);263-268 *
Enhancement of Biological Reactions on Cell Surfaces via Macromolecular Crowding;Rafi Chapanian 等;《NATURE COMMUNICATIONS》;20140820;1-12 *
Identification of a GHII0 Subfamily of Alpha 1,3-galactosidases: Novel Enzymes for Removal ofthe Alpha 3Gal Xenotransplantation Antigen;LIU, Q.P. 等;《J. Biol. Chem.》;20080331;第283卷(第13期);8545-8554 *
Takaaki Kobayashi 等.Removal of blood group A/B antigen in organs by ex vivo and in vivo administration of endo-ß-galactosidase (ABase) for ABO-incompatible transplantation.《Transplant Immunology》.2009,第20卷(第3期),132-138. *

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EP3837370A4 (en) 2022-09-14
US20240294895A1 (en) 2024-09-05
CN112839512A (zh) 2021-05-25
JP7684216B2 (ja) 2025-05-27
CN119662602A (zh) 2025-03-21
WO2020034042A1 (en) 2020-02-20
CN112840027B (zh) 2025-01-10
AU2019322933A1 (en) 2021-03-18
CA3109723A1 (en) 2020-02-20
JP2025131609A (ja) 2025-09-09
US20210345601A1 (en) 2021-11-11
EP3852526A1 (en) 2021-07-28
AU2019322933B2 (en) 2025-08-14
EP3852526A4 (en) 2022-11-02
BR112021002899A2 (pt) 2021-05-11
CN117044707A (zh) 2023-11-14
JP2024163994A (ja) 2024-11-26
CA3116785A1 (en) 2020-02-20
CN112840027A (zh) 2021-05-25
US20210324361A1 (en) 2021-10-21
US20250011749A1 (en) 2025-01-09
EP3837370A1 (en) 2021-06-23
JP2021532838A (ja) 2021-12-02
JP2021533783A (ja) 2021-12-09
WO2020034043A1 (en) 2020-02-20
JP7570316B2 (ja) 2024-10-21

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