CN112805005A - 甲状腺素受体β促效剂化合物 - Google Patents

甲状腺素受体β促效剂化合物 Download PDF

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Publication number
CN112805005A
CN112805005A CN201980066702.0A CN201980066702A CN112805005A CN 112805005 A CN112805005 A CN 112805005A CN 201980066702 A CN201980066702 A CN 201980066702A CN 112805005 A CN112805005 A CN 112805005A
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China
Prior art keywords
substituted
compound
methyl
alkyl
oxo
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CN201980066702.0A
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English (en)
Chinese (zh)
Inventor
T·A·基尔施伯格
R·哈尔康卜
徐英姿
F·A·罗曼罗
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Tuozhen Co ltd
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Tuozhen Co ltd
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Publication of CN112805005A publication Critical patent/CN112805005A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
CN201980066702.0A 2018-08-24 2019-08-23 甲状腺素受体β促效剂化合物 Pending CN112805005A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862722312P 2018-08-24 2018-08-24
US62/722,312 2018-08-24
US201962867117P 2019-06-26 2019-06-26
US62/867,117 2019-06-26
PCT/US2019/047968 WO2020041741A1 (en) 2018-08-24 2019-08-23 Thyroid hormone receptor beta agonist compounds

Publications (1)

Publication Number Publication Date
CN112805005A true CN112805005A (zh) 2021-05-14

Family

ID=69584321

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980066702.0A Pending CN112805005A (zh) 2018-08-24 2019-08-23 甲状腺素受体β促效剂化合物

Country Status (9)

Country Link
US (2) US10800767B2 (https=)
EP (1) EP3840755B1 (https=)
JP (2) JP7579253B2 (https=)
CN (1) CN112805005A (https=)
AU (2) AU2019325656B2 (https=)
CA (1) CA3110520A1 (https=)
MA (1) MA53448A (https=)
TW (1) TWI837169B (https=)
WO (1) WO2020041741A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116554063A (zh) * 2023-05-23 2023-08-08 江苏省农用激素工程技术研究中心有限公司 氟胺磺隆中间体的制备方法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI840423B (zh) 2018-10-12 2024-05-01 美商拓臻股份有限公司 甲狀腺素受體β促效劑化合物
CN111320609A (zh) 2018-12-13 2020-06-23 拓臻股份有限公司 一种THRβ受体激动剂化合物及其制备方法和用途
GEP20247637B (en) 2019-05-08 2024-06-25 Aligos Therapeutics Inc Modulators of thr-b and methods of use thereof
WO2020228577A1 (zh) * 2019-05-10 2020-11-19 深圳微芯生物科技股份有限公司 一种哒嗪酮衍生物及其应用
AU2020336272A1 (en) 2019-08-23 2022-04-14 Terns Pharmaceuticals, Inc. Thyroid hormone receptor beta agonist compounds
CN114375193B (zh) 2019-09-12 2024-05-14 拓臻制药公司 甲状腺激素受体β激动剂化合物
CN114437034A (zh) * 2020-11-06 2022-05-06 深圳微芯生物科技股份有限公司 一种酞嗪类化合物的可药用盐、晶型及其制备方法
CN116670118B (zh) 2020-11-13 2026-02-06 伊尼制药公司 二氯苯酚hsd17b13抑制剂及其用途
CN114621207B (zh) * 2020-12-11 2025-02-11 广东东阳光药业股份有限公司 一种作为甲状腺激素β受体激动剂的化合物及其用途
CA3212130A1 (en) * 2021-03-03 2022-09-09 Terns Pharmaceuticals, Inc. Thyroid hormone receptor beta agonist compounds
WO2022194278A1 (zh) * 2021-03-19 2022-09-22 南京明德新药研发有限公司 双环苯酚类化合物及其应用
CN117624154A (zh) * 2021-03-19 2024-03-01 南京明德新药研发有限公司 双环吡啶酮类化合物及其应用
US20240398794A1 (en) 2023-04-07 2024-12-05 Terns Pharmaceuticals, Inc. COMBINATIONS OF GLP-1R AND THRß AGONISTS AND METHODS OF USE THEREOF

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1471049A1 (en) * 2002-01-30 2004-10-27 Kissei Pharmaceutical Co., Ltd. Novel thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof
CN101228135A (zh) * 2005-07-21 2008-07-23 霍夫曼-拉罗奇有限公司 作为甲状腺激素受体激动剂的哒嗪酮衍生物
US20090247539A1 (en) * 2003-11-24 2009-10-01 Pfizer Inc Novel Pharmaceuticals
US20100286182A1 (en) * 2007-04-18 2010-11-11 Samuels Herbert H Hydrazide compounds as thyroid hormone receptor modulators and uses thereof
US20180030003A1 (en) * 2015-02-13 2018-02-01 Sunshine Lake Pharma Co., Ltd. Tricyclic compounds and uses thereof in medicine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0327319D0 (en) * 2003-11-24 2003-12-24 Pfizer Ltd Novel pharmaceuticals
WO2007132475A1 (en) 2006-05-15 2007-11-22 Cadila Healthcare Limited Selective tr-beta 1 agonist
CN109574995B (zh) 2018-01-23 2020-07-24 深圳市塔吉瑞生物医药有限公司 取代的哒嗪酮化合物
CN111801324B (zh) 2018-06-12 2021-10-22 四川海思科制药有限公司 甲状腺激素受体激动剂及其用途
US12391677B2 (en) 2018-10-12 2025-08-19 InventisBio Co., Ltd. Thyroid hormone receptor agonists

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1471049A1 (en) * 2002-01-30 2004-10-27 Kissei Pharmaceutical Co., Ltd. Novel thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof
US20090247539A1 (en) * 2003-11-24 2009-10-01 Pfizer Inc Novel Pharmaceuticals
CN101228135A (zh) * 2005-07-21 2008-07-23 霍夫曼-拉罗奇有限公司 作为甲状腺激素受体激动剂的哒嗪酮衍生物
US20100286182A1 (en) * 2007-04-18 2010-11-11 Samuels Herbert H Hydrazide compounds as thyroid hormone receptor modulators and uses thereof
US20180030003A1 (en) * 2015-02-13 2018-02-01 Sunshine Lake Pharma Co., Ltd. Tricyclic compounds and uses thereof in medicine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116554063A (zh) * 2023-05-23 2023-08-08 江苏省农用激素工程技术研究中心有限公司 氟胺磺隆中间体的制备方法

Also Published As

Publication number Publication date
AU2019325656B2 (en) 2025-04-24
CA3110520A1 (en) 2020-02-27
TWI837169B (zh) 2024-04-01
MA53448A (fr) 2022-04-20
EP3840755A4 (en) 2022-04-20
JP2025020206A (ja) 2025-02-12
JP7846735B2 (ja) 2026-04-15
EP3840755B1 (en) 2026-02-18
EP3840755A1 (en) 2021-06-30
JP2021535207A (ja) 2021-12-16
AU2025206402A1 (en) 2025-08-07
US10800767B2 (en) 2020-10-13
AU2019325656A1 (en) 2021-03-11
US20200062742A1 (en) 2020-02-27
TW202023560A (zh) 2020-07-01
JP7579253B2 (ja) 2024-11-07
WO2020041741A1 (en) 2020-02-27
US20250236615A1 (en) 2025-07-24

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