CN112791249B

CN112791249B - Cardioplegia fluid perfusion device

Info

Publication number: CN112791249B
Application number: CN202011611152.7A
Authority: CN
Inventors: 胡吉龙; 刘泽成; 袁栋平; 刘三强
Original assignee: Dongguan Kewei Medical Instrument Co Ltd
Current assignee: Dongguan Kewei Medical Instrument Co Ltd
Priority date: 2020-12-30
Filing date: 2020-12-30
Publication date: 2023-02-17
Anticipated expiration: 2040-12-30
Also published as: CN112791249A

Abstract

The invention discloses a cardioplegia fluid perfusion device which comprises an upper cover, a shell, a lower cover, a core body, a plurality of hollow fiber membranes, a middle partition and at least two sealing pieces, wherein a first through hole is formed in the core body and the hollow fiber membranes in the parallel direction, and a second through hole is formed in the middle partition. Through the upper cover, the shell, the lower cover, the core, a plurality of hollow fiber membranes, the cooperation setting of mesophragma piece and two at least sealing members, the upper cover, shell and lower cover constitution shell body, the core, a plurality of hollow fiber membranes, mesophragma piece and two at least sealing members set up in the shell body, blood gets into the core, after flowing out and bypass a plurality of hollow fiber membranes by the first opening on the core, flow to the export by the second opening of mesophragma piece, blood is when initial outflow, carry out the blood alternating temperature with the contact of most hollow fiber membranes, and simultaneously, blood has increased the flow path around the process that hollow fiber membranes flows, make blood and hollow fiber membranes have long-time contact, further promote blood alternating temperature effect.

Description

Cardioplegia fluid perfusion device

Technical Field

The invention relates to the technical field of medical instruments, in particular to a cardioplegia perfusion device.

Background

The cardioplegia perfusion device is widely applied to the field of extracorporeal circulation and the like at present, when in extracorporeal circulation, the heart stops beating, and blood after oxygenation is conveyed back to the body through an oxygenator, a rolling pump or a centrifugal pump and the like. In this process, the blood supply to the heart itself has two functions: oxygen supply of cardiac muscle is ensured, cardioplegia liquid is input into the cardiac muscle, and the cardiac is ensured to keep in a cardioplegia state during operation. Since the temperature of the heart muscle directly affects the oxygen consumption, the higher the temperature, the higher the oxygen consumption, the heart muscle should be kept at a lower temperature (e.g. 4-10 degrees centigrade) during the operation, and the temperature of the heart should be returned to normal body temperature before the operation is finished.

At present, the materials used by the cardioplegia perfusion device comprise metal, plastic coils, hollow fiber membranes and the like, and the perfusion device gradually turns from metal to the hollow fiber membrane materials due to the factors such as the biocompatibility, the convenience and the price of the materials and the like. Patent application No. CN201620554691.4 discloses a cardioplegia perfusion apparatus, and as can be seen from figure 2 of the application, blood enters a blood storage tank from a blood inlet and then enters a space between a shell and an inner core, because the opening of the blood entering the shell and the inner core is obviously far lower than one end of a hollow fiber membrane bundle, a part of the hollow fiber membrane bundle is easily not used, and the utilization efficiency of a hollow fiber membrane is reduced; in addition, the blood mainly flows along the axial direction of the hollow fiber membrane bundle, the contact area with the peripheral hollow fiber membrane bundle is small, and the temperature control effect is not ideal.

Disclosure of Invention

Aiming at the defects of the prior art, the invention provides a cardioplegia perfusion device.

The invention discloses a cardioplegia perfusion device, comprising: the sealing device comprises an upper cover, a shell, a lower cover, a core body, a plurality of hollow fiber membranes, a middle partition piece and at least two sealing pieces, wherein the upper cover and the lower cover are arranged at two ends of the shell, the at least two sealing pieces are respectively arranged on the upper cover and the lower cover, the core body, the plurality of hollow fiber membranes and the middle partition piece are sequentially arranged from inside to outside at intervals, and the sealing pieces are used for fixing the core body, the plurality of hollow fiber membranes and the middle partition piece, wherein the sealing pieces are formed by centrifugal glue pouring (such as polyurethane glue).

The core has seted up first opening on with the hollow fiber membrane parallel direction, and the second opening has been seted up to well spacer, and blood flows in the core to flow out through first opening, the blood of outflow flows to the export through the second opening after flowing around core and a plurality of hollow fiber membrane.

According to an embodiment of the present invention, the filter membrane is provided between the septum and the housing.

According to an embodiment of the present invention, a flow guiding plate is formed in the core, and the blood flows to the first port along the flow guiding plate after entering the core.

According to one embodiment of the present invention, the outer wall surface of the casing is provided with an exhaust pipe through which gas in blood is exhausted.

According to one embodiment of the present invention, the lower cover is provided with a temperature changing liquid inlet pipe, and the temperature changing liquid inlet pipe is communicated with one end of the hollow fiber membrane.

According to one embodiment of the present invention, the upper cover is provided with a temperature change liquid outlet pipe, and the temperature change liquid outlet pipe is communicated with the other end of the hollow fiber membrane.

According to an embodiment of the present invention, the upper cover is provided with a blood inlet tube therethrough, and the blood inlet tube communicates with the core body.

According to one embodiment of the present invention, the housing has a blood vessel extending therethrough, the blood vessel communicating with a space between the housing and the septum.

According to one embodiment of the present invention, the blood outlet tube is provided with a pressure measuring tube at a portion exposed to the outside.

According to one embodiment of the present invention, the portion of the blood outlet tube exposed to the outside is provided with a temperature measuring tube.

According to an embodiment of the present invention, the pressure measuring tube and the temperature measuring tube may be integrated with each other at a portion of the blood outlet tube exposed to the outside.

The blood temperature changing device has the advantages that the upper cover, the shell, the lower cover, the core body, the hollow fiber membranes, the middle partition piece and the at least two sealing pieces are arranged in a matched mode, the upper cover, the shell and the lower cover form the shell body, the core body, the hollow fiber membranes, the middle partition piece and the at least two sealing pieces are arranged in the shell body, blood enters the core body, flows out from the first through hole in the core body and bypasses the hollow fiber membranes, then flows out from the second through hole in the middle partition piece and flows to the outlet, the blood is in contact with most of the hollow fiber membranes to change the temperature of the blood, meanwhile, the flow path is increased in the process that the blood flows around the hollow fiber membranes, the blood is in contact with the hollow fiber membranes for a long time, and the blood temperature changing effect is further improved.

Drawings

The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the application and together with the description serve to explain the application and not to limit the application. In the drawings:

FIG. 1 is a perspective view of a cardioplegia perfusion device according to an embodiment;

FIG. 2 is a sectional view of a cardioplegia perfusion device according to an embodiment;

FIG. 3 is a partial block diagram of a cardioplegia perfusion device according to an embodiment;

FIG. 4 is a perspective view of the upper cover in the embodiment;

fig. 5 is another partial structure diagram of the cardioplegia perfusion device in the embodiment.

Description of the reference numerals

1, covering the cover; 11-a temperature change liquid outlet pipe; 12-a blood inlet tube; 13-a first card slot; 14-a third card slot;

2-a housing; 21-an exhaust pipe; 22-bleeding; 221-piezometric tube; 222-a temperature measuring tube; 23-a second card slot; 24-a fourth card slot;

3-lower cover; 31-a temperature change liquid inlet pipe;

4-a core body; 41-a first port; 42-a flow guide plate;

5-hollow fiber membranes;

6-a septum; 61-second port;

7-a seal;

8-filtering membrane.

Detailed Description

In the following description, for purposes of explanation, numerous implementation details are set forth in order to provide a thorough understanding of the various embodiments of the present invention. It should be understood, however, that these implementation details are not to be interpreted as limiting the invention. That is, in some embodiments of the invention, such implementation details are not necessary. In addition, some conventional structures and components are shown in simplified schematic form in the drawings.

In addition, the descriptions related to the first, the second, etc. in the present invention are only used for description purposes, do not particularly refer to an order or sequence, and do not limit the present invention, but only distinguish components or operations described in the same technical terms, and are not understood to indicate or imply relative importance or implicitly indicate the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, technical solutions between the embodiments may be combined with each other, but must be based on the realization of the technical solutions by a person skilled in the art, and when the technical solutions are contradictory to each other or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention.

As shown in fig. 1-3, fig. 1 is a perspective view of a cardioplegia perfusion device in an embodiment; FIG. 2 is a sectional view of a cardioplegia perfusion device according to an embodiment; fig. 3 is a partial structure diagram of a cardioplegia perfusion device in an embodiment. The cardioplegia fluid perfusion device comprises an upper cover 1, a shell 2, a lower cover 3, a core 4, a plurality of hollow fiber membranes 5, a middle partition 6 and at least two sealing pieces 7, wherein the upper cover 1 and the lower cover 3 are respectively arranged at two ends of the shell 2, the at least two sealing pieces 7 are respectively positioned at two ends of the shell 2, the two ends of the core 4 are connected with the at least two sealing pieces 7, the hollow fiber membranes 5 are arranged around the core 4, and the two ends of the hollow fiber membranes 5 penetrate through the at least two sealing pieces 7, wherein the sealing pieces 7 can be formed by centrifugal glue filling (such as polyurethane glue); the septum 6 wraps the hollow fiber membranes 5, a gap exists between the septum 6 and the shell 2, two ends of the septum 6 are also connected with at least two sealing pieces 7, and the core body 4, the hollow fiber membranes 5 and the middle compartments are sequentially sleeved at intervals from inside to outside. First opening 41 has been seted up to core 4, the orientation of seting up of first opening 41 is parallel with the direction of hollow fiber membrane 5, and second opening 61 has been seted up to well spacer 6, and first opening 41 and second opening 61 dislocation set, first opening 41 and second opening 61 are promptly not just to seting up, and blood flows in behind core 4, flows out through first opening 41, and the blood that flows out flows around core 4 and a plurality of hollow fiber membrane 5 after flowing, by the export of second opening 61 flow direction.

In a specific application, the second opening 61 may be disposed at any position of the septum 6, and it is only necessary that the second opening 61 and the first opening 41 are not disposed face to face, in this embodiment, the direction in which blood flows out from the first opening 41 is set as the front, and the direction opposite to the front is set as the rear; the second port 61 is located behind the first port 41, and blood flows out from the front of the first port 41, then flows towards two sides with the core 4 as the center, bypasses the plurality of hollow fiber membranes 5 and then reaches the second port 61, and the positions of the first port 41 and the second port 61 are arranged, so that the path for the blood to flow is prolonged, the contact time and the contact area between the blood and the hollow fiber membranes 5 are increased, and the blood achieves a better temperature change effect.

Preferably, the length of seting up of first opening 41 is close with the length of hollow fiber membrane 5, prevents that blood flow is obstructed, the phenomenon of jam and stagnation, when guaranteeing that blood flow is smooth and easy, can also increase the effective contact area of blood and hollow fiber membrane 5, avoids hollow fiber membrane 5 some unable with blood contact, causes the waste of resource, reduces blood alternating temperature effect simultaneously.

Referring to fig. 2, preferably, a baffle 42 is disposed in the core 4, the baffle 42 is disposed at an angle to the first opening 41, and the baffle 42 guides the blood to the first opening 41 for discharging, so as to increase the blood flow speed and prevent the blood from remaining in the core 4.

Referring to fig. 4, fig. 4 is a perspective view of the upper cover 1 according to the embodiment. The upper cover 1 is provided with a temperature change liquid outlet pipe 11, the temperature change liquid outlet pipe 11 is communicated with one end of the plurality of hollow fiber membranes 5, and the temperature change liquid in the plurality of hollow fiber membranes 5 is discharged to the outside through the temperature change liquid outlet. In specific application, the temperature-changing liquid outlet pipe 11 may be disposed at the edge of the upper cover 1, or may be disposed at the top of the upper cover 1, and in this embodiment, the temperature-changing liquid outlet pipe 11 is disposed at the edge of the upper cover 1. Preferably, the upper cover 1 is further provided with a blood inlet tube 12, the blood inlet tube 12 is arranged through the upper cover 1, the blood inlet tube 12 is communicated with the core 4, and blood enters the core 4 through the blood inlet tube 12. In a specific application, the blood inlet tube 12 may be disposed at the edge of the upper cover 1, or disposed at the top of the upper cover 1, specifically, the blood inlet tube 12 is disposed at the top of the upper cover 1. Further preferably, the upper cover 1 is further provided with a first clamping groove 13, the sealing element 7 is provided with a clamping block (not marked in the figure), the clamping block is matched with the first clamping groove 13, and the clamping block is clamped into the first clamping groove 13, so that the sealing element 7 is fixed. During the specific application, the quantity of first draw-in groove 13 is two, and two first draw-in grooves 13 set up relatively, and the quantity of the fixture block that corresponds also is two, and two fixture blocks also set up relatively, improve fixed effect and stability to sealing member 7.

Preferably, referring to fig. 2-3 again, an exhaust pipe 21 is disposed on the outer wall surface of the housing 2, the exhaust pipe 21 is communicated with the inside of the housing 2, and the gas in the blood is exhausted through the exhaust pipe 21. It is further preferred that the housing 2 is further provided with a blood outlet tube 22, the blood outlet tube 22 communicating with a gap between the housing 2 and the septum 6, and the blood after temperature change is discharged through the blood outlet tube 22. Still more preferably, the exhaust pipe 21 is provided with a pressure measuring pipe 221, the pressure measuring pipe 221 is located in an area where the blood outlet tube 22 is exposed to the outside, the pressure measuring pipe 221 is communicated with the inside of the blood outlet tube 22, and the pressure measuring device is externally connected through the pressure measuring pipe 221, so that the blood pressure of the blood in the blood outlet tube 22 can be monitored. Still further preferably, a temperature measuring tube 222 is further disposed on the blood outlet tube 22, the temperature measuring tube 222 is communicated with the inside of the blood outlet tube 22, similarly, the temperature measuring tube 222 is disposed on the exposed portion of the blood outlet tube 22, the temperature measuring tube 222 can be externally connected to a corresponding temperature measuring device, and can monitor the temperature of blood in the blood outlet tube 22, it can be understood that the pressure measuring tube 221 and the temperature measuring tube 222 can be integrated, and directly externally connected to a corresponding pressure measuring and temperature measuring integrated device.

Still further preferably, the housing 2 is further provided with a second clamping groove 23, the second clamping groove 23 has the same structure as the first clamping groove 13, and both the second clamping groove 23 and the first clamping groove 13 are clamped with the clamping block to fix the sealing element 7; in a specific application, the number of the second card slots 23 is also two. In addition, the length that second draw-in groove 23 was seted up is the same with the length of shell 2, and blast pipe 21 and play blood vessel 22 set up respectively in the outer wall of different second draw-in groove 23, not only makes things convenient for the setting of blast pipe 21 with play blood vessel 22, has increased the route of blood flow through simultaneously, and then has increased dwell time for blood fully exhausts and more smoothly discharges.

Referring to fig. 2-4, the upper cover 1 is further provided with a third engaging groove 14, the end of the housing 2 is provided with a fourth engaging groove 24, and the third engaging groove 14 is adapted to the fourth engaging groove 24, that is, the third engaging groove 14 is engaged with the fourth engaging groove 24, so that the upper cover 1 and the housing 2 are combined into a whole, and the upper cover 1 is prevented from being separated from the housing 2.

Preferably, the lower cover 3 is provided with a temperature changing liquid inlet pipe 31, the temperature changing liquid inlet pipe 31 is communicated with one end of the hollow fiber membrane 5 far away from the upper cover 1, the temperature changing liquid is discharged into the hollow fiber pipe through the temperature changing liquid inlet pipe 31, and then is discharged to the temperature changing liquid outlet pipe 11 through the hollow fiber pipe to discharge the temperature changing liquid. Specifically, the temperature changing liquid inlet pipe 31 is provided at the edge of the lower cover 3. It should be noted that the structure of the lower cover 3 connecting the housing 2 and the sealing member 7 is the same as that of the upper cover 1, and details thereof will not be described herein.

When the temperature-changing liquid circulation device is used specifically, the hollow fiber membrane 5 is of a slender tubular structure and is of a hollow structure, two ends of the hollow fiber membrane respectively penetrate through the sealing element 7 and are respectively communicated with the temperature-changing liquid inlet pipe 31 and the temperature-changing liquid outlet pipe 11, temperature-changing liquid flows in the hollow fiber membrane 5, blood flows and contacts the outer surface of the hollow fiber membrane 5, and heat exchange is carried out between the blood and the temperature-changing liquid in the mesoporous fiber membrane in the flowing process of the blood, so that the temperature-changing treatment of the blood is realized.

Fig. 5 is another partial structural view of the cardioplegia perfusion device in the embodiment shown in fig. 5. Referring to fig. 2 to 3 together, the cardioplegia perfusion apparatus preferably further includes a filtering membrane 8, and the filtering membrane 8 is disposed between the septum 6 and the inner wall surface of the housing 2, and the blood is filtered by the filtering membrane 8. In particular applications, the filtering membrane 8 may be disposed around the septum 6, or may be disposed only at the input end of the blood outlet tube 22; in this embodiment, two ends of filtering membrane 8 are respectively clamped on two sealing members 7 for fixation, and filtering membrane 8 is located at the notch of second clamping groove 23 provided with blood outlet tube 22, and blood is filtered through filtering membrane 8 after flowing out from second notch 61, and finally flows out from blood outlet tube 22. Specifically, the filtering membrane 8 is disposed in front of the first through hole 41, and the second through hole 61, the first through hole 41 and the filtering membrane 8 are disposed side by side on the same horizontal line, so as to ensure a sufficiently long flow path for blood, increase the storage capacity of the device, and reduce the overall volume.

When the cardioplegia perfusion device works, temperature-changing liquid flows in from a temperature-changing liquid inlet pipe 31, the temperature-changing liquid flows through the hollow fiber membranes 5 and then is discharged from a temperature-changing liquid outlet pipe 11, the input and the output of the temperature-changing liquid are continuously kept, blood flows in from a blood inlet pipe 12, the blood flows in the core body 4 and flows out through the first through hole 41 under the action of the guide plate 42, the flowing blood is contacted with the hollow fiber membranes 5, the blood flows to the second through hole 61 around the hollow fiber membranes 5, the blood flowing out from the second through hole 61 flows to the filtering membrane 8 around the middle partition piece 6, the blood filtered by the filtering membrane 8 flows to the blood outlet pipe 22 and is finally discharged through the blood outlet pipe 22, the whole flow path of the blood in the device is similar to M, and the blood flow path is favorable for improving the blood flow path.

In summary, through the matching arrangement of the upper cover, the shell, the lower cover, the core, the plurality of hollow fiber membranes, the middle partition and at least two sealing elements, the outer shell is composed of the upper cover, the shell and the lower cover, the core, the plurality of hollow fiber membranes, the middle partition and the at least two sealing elements are arranged in the outer shell, blood enters the core, flows out from the first opening of the core and bypasses the plurality of hollow fiber membranes, then flows out from the second opening of the middle partition and flows to the outlet, and when the blood initially flows out, the blood contacts with most of the hollow fiber membranes to change the temperature of the blood.

The above description is only an embodiment of the present invention, and is not intended to limit the present invention. Various modifications and alterations to this invention will become apparent to those skilled in the art. Any modification, equivalent replacement, improvement or the like made within the spirit and principle of the present invention should be included in the scope of the claims of the present invention.

Claims

1. A cardioplegic fluid infusion device, comprising: the sealing device comprises an upper cover (1), a shell (2), a lower cover (3), a core body (4), a plurality of hollow fiber membranes (5), a middle partition piece (6) and at least two sealing pieces (7), wherein the upper cover (1) and the lower cover (3) are arranged at two ends of the shell (2), the at least two sealing pieces (7) are respectively arranged on the upper cover (1) and the lower cover (3), the core body (4), the plurality of hollow fiber membranes (5) and the middle partition piece (6) are sequentially arranged at intervals from inside to outside, and the sealing pieces (7) are used for fixing the core body (4), the plurality of hollow fiber membranes (5) and the middle partition piece (6);

a first through hole (41) is formed in the core (4) and the hollow fiber membranes (5) in the parallel direction, a second through hole (61) is formed in the middle partition (6), blood flows into the core (4) and flows out through the first through hole (41), and the flowing-out blood flows around the core (4) and the hollow fiber membranes (5) and then flows to an outlet through the second through hole (61); the opening length of the first through hole (41) is close to that of the hollow fiber membrane (5), so that the phenomena of unsmooth blood flow, blockage and stagnation are prevented, the smooth blood flow is ensured, meanwhile, the effective contact area of the blood and the hollow fiber membrane (5) can be increased, the waste of resources caused by the fact that some parts of the hollow fiber membrane (5) cannot be in contact with the blood is avoided, and the blood temperature change effect is reduced;

the core (4) still includes guide plate (42), guide plate (42) with first opening (41) become the contained angle setting, blood process behind guide plate (42) flow to first opening (41).

2. Cardioplegic fluid perfusion apparatus according to claim 1, further comprising a filter membrane (8), the filter membrane (8) being arranged between the septum (6) and the housing (2).

3. The cardioplegia perfusion device according to claim 2, wherein the outer wall surface of the casing (2) is provided with an exhaust pipe (21), and the gas in the blood is exhausted through the exhaust pipe (21).

4. The cardioplegia perfusion device according to any one of claims 1-3, wherein the lower cover (3) is provided with a temperature-variable liquid inlet pipe (31), and the temperature-variable liquid inlet pipe (31) is communicated with one end of the hollow fiber membrane (5).

5. The cardioplegia perfusion device according to claim 4, wherein the upper cover (1) is provided with a temperature changing liquid outlet pipe (11), and the temperature changing liquid outlet pipe (11) is communicated with the other end of the hollow fiber membrane (5).

6. The cardioplegia perfusion device according to any one of claims 1-3, wherein the upper cover (1) is provided with a blood inlet pipe (12) in a penetrating manner, and the blood inlet pipe (12) is communicated with the core body (4).

7. The cardioplegia perfusion device according to claim 6, wherein a blood outlet tube (22) extends through the casing (2), and the blood outlet tube (22) communicates with a gap between the casing (2) and the septum (6).

8. The cardioplegia perfusion device according to claim 7, wherein the portion of the blood outlet tube (22) exposed to the outside is provided with a pressure measuring tube (221).

9. The cardioplegia perfusion device according to claim 7, wherein the portion of the blood outlet tube (22) exposed to the outside is provided with a temperature measuring tube (222).