JPS5838563A - Hollow yarn type blood dialysis apparatus - Google Patents
Hollow yarn type blood dialysis apparatusInfo
- Publication number
- JPS5838563A JPS5838563A JP56137314A JP13731481A JPS5838563A JP S5838563 A JPS5838563 A JP S5838563A JP 56137314 A JP56137314 A JP 56137314A JP 13731481 A JP13731481 A JP 13731481A JP S5838563 A JPS5838563 A JP S5838563A
- Authority
- JP
- Japan
- Prior art keywords
- dialysate
- blood
- hollow fiber
- resistance
- type blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1633—Constructional aspects thereof with more than one dialyser unit
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
本発明は中空糸型血液透析装置に関するものであり、と
くに低流量の透析液を使用して従来どおりの効率の得ら
れる中空糸型血液透析装置を提供することを目的とする
ものである。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a hollow fiber type hemodialysis device, and in particular, an object of the present invention is to provide a hollow fiber type hemodialysis device that uses a low flow rate of dialysate and can obtain the same efficiency as before. That is.
腎不全等の患者の生命維持のための血液透析は広く採用
されるところとなっているが、高嘔の処置費用を必要と
し、そのうち多量に使用される透析液の費用は加熱のた
めのエネルギー費を含めて相当な金額となりその節減が
望まれている。Hemodialysis is now widely used to support the lives of patients suffering from renal failure, etc., but it requires high treatment costs, including the cost of the dialysate, which is used in large quantities, and the energy required to heat it. It is a considerable amount of money including expenses, and it is hoped that it can be reduced.
従来の中空糸型血液透析器は一般に５００＋ｌ／／分の
透析液流量で実用的な透析効率の得られるように設計さ
れ、５００ｇ／／分以下の透析液流量では極端に効率の
低下することが知られており、血液透析器内の中空糸の
充填密度を大として従来どおりの透析液流速の下に透析
液流量の低下を目的とする試みがあった−が血液透析器
内の透析液に偏流を生じ、透析液の停滞のための効率低
下をもたらした。Conventional hollow fiber hemodialyzers are generally designed to provide practical dialysis efficiency at a dialysate flow rate of 500+ l/min, and the efficiency may drop dramatically at a dialysate flow rate of 500 g/min or less. It is known that there have been attempts to reduce the dialysate flow rate by increasing the packing density of the hollow fibers in the hemodialyzer, while maintaining the conventional dialysate flow rate. This resulted in uneven flow and reduced efficiency due to stagnation of the dialysate.
本発明は低流量の透析液を使用し従来どおりの効率の得
られるように血液透析器内の透析液流速を偏流を伴うこ
となく維持できる中空糸型血液透析器を提供するもので
あり、また透析液消費量が僅かであるので透析液の供給
量と排出量の差として求められ１．る限外濾過量の測定
が正確に行われる中空糸血液透析器を提供するものであ
って、以下本発明の実施例を図面に基いて説明する。The present invention provides a hollow fiber hemodialyzer that can maintain the dialysate flow rate within the hemodialyzer without uneven flow so as to obtain the same efficiency as before using a low flow rate of dialysate; Since the amount of dialysate consumed is small, it is calculated as the difference between the amount of dialysate supplied and the amount discharged.1. Embodiments of the present invention will be described below with reference to the drawings.
本発明の中空糸型血液透析装置１は複数の通常形式の小
型同サイズの中空糸型血液透析器２のそれぞれの中空糸
内および中空糸内と連通して血液の出入口となる作液ポ
ート３．３とによって構成される血液室が血液マニホー
ルド５．５によって並列に連結され、小型中空糸型面液
・透析器のそれぞれの中空糸外および中空糸外と連通ず
る透析液の出入口である透析液ポート４．４が接続チュ
ーブ６．６．６によって透析液が血流に逆行するごとく
透析液室が直列に連結されたものであり、図示では２台
の小型中空糸型血液透析器が示されているが２台に限定
されるものではない。The hollow fiber hemodialyzer 1 of the present invention has a liquid production port 3 that communicates with the inside of each hollow fiber of a plurality of conventional small-sized hollow fiber hemodialyzers 2 of the same size and serves as an inlet and an inlet for blood. .3 are connected in parallel by a blood manifold 5.5, which is a dialysis fluid inlet/outlet communicating with the outside of each hollow fiber of the small hollow fiber type dialyzer and the outside of the hollow fiber. The dialysate chambers are connected in series so that the fluid port 4.4 is connected to the connecting tube 6.6.6 so that the dialysate flows against the blood flow, and the illustration shows two small hollow fiber hemodialyzers. However, the number is not limited to two.
本発明は上記のごとく構成されているので、透析器の台
数を増加させるほど血流が分散されるので血液抵抗が小
となり、逆に透析液は流路が延長されるので透析液抵抗
が増大する傾向があるが、一般に透析膜面積は患者側々
に応じて定まるものであるので、同一透析膜面積におい
て比較すると血′液抵抗は透析器の台数に無関係８にほ
ぼ等しくなる。Since the present invention is configured as described above, as the number of dialyzers increases, the blood flow becomes more dispersed and the blood resistance decreases, and conversely, the flow path of the dialysate is lengthened, so the dialysate resistance increases. However, since the area of the dialysis membrane is generally determined depending on the patient, when comparing the same area of the dialysis membrane, the blood resistance is approximately equal regardless of the number of dialyzers.
本発明は従来の中空糸型血液透析器を小型化して複数の
透析器を使用して同一膜面積とし、血液室が並列連結さ
れ透析液室が血流に逆行して直列連結された装置であり
、本装置を構成する小型中空糸型血液透析器１台当りの
内蔵する中空糸数は、従来の透析器と比較して非常に減
少するので透析器内の中空糸充填密度を大巾に増大せし
めても高流速透析液使用時における透析液の偏流を生じ
ることなくすべての中空糸の外面が高速透析液と接触し
て低流量透析液によって従来以上の透析効率を得ること
ができる。The present invention is a device that miniaturizes the conventional hollow fiber hemodialyzer and uses multiple dialyzers to have the same membrane area.The blood chambers are connected in parallel and the dialysate chambers are connected in series in a direction opposite to the blood flow. Yes, the number of built-in hollow fibers per small hollow fiber hemodialyzer that constitutes this device is greatly reduced compared to conventional dialyzers, so the packing density of hollow fibers inside the dialyzer is greatly increased. At the very least, the outer surfaces of all the hollow fibers come into contact with the high-speed dialysate without causing any uneven flow of the dialysate when using the high-flow dialysate, and a higher dialysis efficiency than before can be obtained by using the low-flow dialysate.
本発明者は上記観点に基づき鋭意研究の結果本装置の血
液抵抗は３・占−” ｓ ）・流体を標準としたとき
血流量２００ ｗｅ／ｍｉｓにおいて２０ないし１００
ｍｍＨｇであり、透析液抵抗は透析液流量が２００
ｗｌ、省のとき２０ないし１００簡１（ｇであることが
最適であることを見出した。Based on the above viewpoint, the present inventor conducted extensive research and found that the blood resistance of the present device is 3.20 to 100 at a blood flow rate of 200 we/mis when the fluid is the standard.
mmHg, and the dialysate resistance is 200 mmHg.
I found that 20 to 100 grams is optimal when weighing wl.
上記血液抵抗は中空糸内で溶血あるいは凝血を生じない
許容範囲内であり、透析液抵抗は従来方式よりも遥かに
低流量域でも透析器内の透析液の偏流を生じることなく
高流速が得られ高効率の結果の得られる範囲内である。The above blood resistance is within the permissible range that does not cause hemolysis or coagulation within the hollow fiber, and the dialysate resistance is much lower than the conventional method, which allows high flow rates without causing uneven flow of dialysate in the dialyzer. is well within the range of obtaining highly efficient results.
従来方式と比較した実験結果の一例を示すと、透析膜面
積０．７−の小型中空糸型血液透析器２台を使用した本
発明の装置は血流量および透析液流量とも２００ ｓｔ
／／ｌｉｎにおける尿素クリアランスは１４３ ｚｔ／
ｌｉｎであって臨床上問題なく、同一膜面積すなわち１
．４２の１台の透析器を同一条件で使用したときの尿素
クリアランスは１２８１１１／ｍであって臨床上有効に
使用するには透析液流量の増加を必要とした。An example of the experimental results compared with the conventional method is that the device of the present invention, which uses two small hollow fiber hemodialyzers with a dialysis membrane area of 0.7 mm, has a blood flow rate and a dialysate flow rate of 200 st.
//lin urea clearance is 143 zt/
lin, there is no clinical problem, and the same membrane area, i.e. 1
．． When one dialyzer of 42 was used under the same conditions, the urea clearance was 128111/m, which required an increase in the dialysate flow rate for clinically effective use.
図面は本発明の実施例の正面図であり２は小型中空糸型
血液透析器、３は血液ポート、４は透析液ポートである
。
特許出願人
中周 成之輔The drawing is a front view of an embodiment of the present invention, in which 2 is a small hollow fiber hemodialyzer, 3 is a blood port, and 4 is a dialysate port. Patent applicant Seinosuke Nakashu
Claims (1)
並列に連結され、透析液が血流に逆行するごとく透析液
室が直列に連結され、全体としての血液抵抗が３ ｃｐ
ｓ （７）ニュートン流体を標準としたとき、血流量２
００ ｚｌｙ’ｍｉｎにおいて２０ないし１００ ｗｎ
Ｈｇであり、全体としての透析液抵抗が遺析液流量２０
０ ｔｘｌＡｉｎのとき、２ｏないし１００ ｍＨｇで
あることを特徴とする中空糸型血液透析装置。The blood chambers of multiple small hollow fiber hemodialyzers of the same size are connected in parallel, and the dialysate chambers are connected in series so that the dialysate flows against the blood flow, resulting in an overall blood resistance of 3 cp.
s (7) When Newtonian fluid is standard, blood flow 2
20 to 100 wn in 00 zly'min
Hg, and the overall dialysate resistance is 20
A hollow fiber hemodialysis device characterized in that when 0 txlAin, the blood pressure is 2o to 100 mHg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56137314A JPS5838563A (en) | 1981-08-31 | 1981-08-31 | Hollow yarn type blood dialysis apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56137314A JPS5838563A (en) | 1981-08-31 | 1981-08-31 | Hollow yarn type blood dialysis apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5838563A true JPS5838563A (en) | 1983-03-07 |
Family
ID=15195784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56137314A Pending JPS5838563A (en) | 1981-08-31 | 1981-08-31 | Hollow yarn type blood dialysis apparatus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5838563A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH682307A5 (en) * | 1991-02-05 | 1993-08-31 | Alusuisse Lonza Services Ag | |
| JP2005520643A (en) * | 2002-03-27 | 2005-07-14 | ガンブロ ルンデイア アクチーボラグ | Method and apparatus for removing substances partially bound to protein |
| JP5619270B2 (en) * | 2011-02-23 | 2014-11-05 | 旭化成メディカル株式会社 | Blood purification equipment |
-
1981
- 1981-08-31 JP JP56137314A patent/JPS5838563A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH682307A5 (en) * | 1991-02-05 | 1993-08-31 | Alusuisse Lonza Services Ag | |
| JP2005520643A (en) * | 2002-03-27 | 2005-07-14 | ガンブロ ルンデイア アクチーボラグ | Method and apparatus for removing substances partially bound to protein |
| JP2014028290A (en) * | 2002-03-27 | 2014-02-13 | Gambro Lundia Ab | Device for removal of partially protein bound substance |
| JP5619270B2 (en) * | 2011-02-23 | 2014-11-05 | 旭化成メディカル株式会社 | Blood purification equipment |
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