CN112791173A - Traditional Chinese medicine composition for treating Parkinson's disease and preparation method and pharmaceutical application thereof - Google Patents
Traditional Chinese medicine composition for treating Parkinson's disease and preparation method and pharmaceutical application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating Parkinson's disease, a preparation method and a pharmaceutical application thereof, and the traditional Chinese medicine composition comprises 15-25 parts of cistanche, 15-22 parts of dogwood, 10-15 parts of ligusticum wallichii, 15-25 parts of polygala tenuifolia, 22-30 parts of rhizoma acori graminei, 2-5 parts of leech, 15-25 parts of salvia miltiorrhiza and 3-8 parts of ginger. The traditional Chinese medicine composition has a good treatment effect on speech functions and epilepsy of patients through the combination of a plurality of traditional Chinese medicine components, can exert the drug effect to the maximum extent, enables the patients to be treated well, has a remarkable treatment effect, is suitable for long-term administration, and has a good application prospect.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine composition for treating Parkinson's disease, a preparation method and a pharmaceutical application thereof.
Background
The Parkinson disease is the second most degenerative disease of the nervous system, the annual incidence rate is about 362/10 ten thousands, and in 2005, Parkinson patients reach 200 thousands in China, which brings a heavy medical burden to the society. The typical pathological changes in parkinson's disease are the formation of lewy bodies within neurons and the progressive loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain, and thus, protection of dopaminergic neurons, reduction of dopaminergic neuron apoptosis and loss are fundamental means of delaying disease progression. However, current clinical treatment of parkinson's disease only improves symptoms and does not reduce neuronal apoptosis and loss.
Typical symptoms of Parkinson's disease are myotonia, bradykinesia, resting tremor, and non-motor symptoms such as olfactory loss, sleep disorders, constipation, depression, etc., and are sensitive to dopa preparations. The characteristic pathological changes are the formation of lewy bodies in neurons and the progressive loss of nigral dopaminergic neurons.
The Chinese medicine considers that the human body movement regulation function is closely related to the functions of kidney, liver, heart and brain. The substantia nigra neurons are the central nervous system, and when the essence of the substantia nigra neurons is nourished by kidney essence, kidney water is deficient, kidney essence is deficient, and brain and marrow are not nourished, the substantia nigra neurons gradually degenerate and reduce, denature and necrotize, and the corresponding parts of the midbrain naturally become light black. The substantia nigra neurons synthesize dopamine, as if the kidney essence transforms into blood, to nourish the liver meridian. The liver is nourished by blood, and has soft nature, if the degeneration of the substantia nigra neurons is reduced, the synthesized dopamine is also reduced, and the excess is the deficiency of kidney essence and the blood transformation failure of essence, so that the liver blood deficiency is less, the liver is used too strongly, and the liver is too loose and over-drained, the liver yang is excessive, and the liver wind moves inwards; in addition, the deficiency of the kidney fails to transform qi and promote diuresis, and the liver deficiency fails to dredge qi and causes phlegm-dampness accumulation and qi and blood stasis. Thereby forming pathological products of wind-phlegm-dampness-stasis, disturbing the upper-jiao clear, disturbing the brain collaterals and obstructing the channels, muscles and bones. Wind-phlegm-dampness-stasis can be disturbed, so abnormal deposition of protein in brain can be seen. The liver stores blood, mainly regulates and relieves diarrhea, has yin and soft body, uses yang and hard body, and is full of liver blood, so that meridians and bones can be nourished, thereby ensuring flexible limbs and movement; if the liver blood is deficient and the meridians and bones fail to nourish, it will be spasm and stiffness and inflexible. Liver governing wind, "all wind falling dizziness and falling dizziness all belong to liver", wind phlegm dampness stasis, cross-talk in channels and collaterals, and obstruction of muscles and bones to cause tremor of limbs, and spasm, rigidity and straightness.
The existing medicine for treating Parkinson's disease is weak in functionality due to medicine components in actual use, and can be used for treating Parkinson's disease, but complications caused by Parkinson's disease cannot be well prevented and treated, so that the condition of a patient is often worsened due to the complications in clinical treatment.
Therefore, it is necessary to invent a preparation method of a Chinese medicinal composition for treating Parkinson's disease to solve the above problems.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating Parkinson's disease, a preparation method and a pharmaceutical application thereof.
In order to achieve the above purpose, the invention provides the following technical scheme: a preparation method of a traditional Chinese medicine composition for treating Parkinson disease comprises 15-25 parts of rhizoma anemarrhenae, 15-25 parts of cistanche, 15-22 parts of dogwood, 10-15 parts of ligusticum wallichii, 15-25 parts of polygala tenuifolia, 22-30 parts of rhizoma acori graminei, 2-5 parts of leech, 15-25 parts of salvia miltiorrhiza and 3-8 parts of ginger.
Preferably, 20 parts of rhizoma anemarrhenae, 15 parts of cistanche, 18 parts of dogwood, 12 parts of ligusticum wallichii, 18 parts of polygala tenuifolia, 25 parts of rhizoma acori graminei, 3 parts of leech, 18 parts of salvia miltiorrhiza and 5 parts of ginger.
Preferably, the traditional Chinese medicine composition comprises 15 parts of rhizoma anemarrhenae, 15 parts of cistanche, 15 parts of dogwood, 10 parts of ligusticum wallichii, 15 parts of polygala tenuifolia, 22 parts of rhizoma acori graminei, 2 parts of leech, 15 parts of salvia miltiorrhiza and 3 parts of ginger.
Preferably, the traditional Chinese medicine composition comprises 25 parts of rhizoma anemarrhenae, 25 parts of cistanche, 22 parts of dogwood, 15 parts of ligusticum wallichii, 25 parts of polygala tenuifolia, 30 parts of rhizoma acori graminei, 5 parts of leech, 25 parts of salvia miltiorrhiza and 8 parts of ginger.
Preferably, 18 parts of rhizoma anemarrhenae, 18 parts of cistanche, 20 parts of dogwood, 13 parts of ligusticum wallichii, 20 parts of polygala tenuifolia, 27 parts of rhizoma acori graminei, 4 parts of leech, 20 parts of salvia miltiorrhiza and 6 parts of ginger.
Preferably, 24 parts of rhizoma anemarrhenae, 24 parts of cistanche, 21 parts of dogwood, 14 parts of ligusticum wallichii, 23 parts of polygala tenuifolia, 28 parts of rhizoma acori graminei, 4 parts of leech, 23 parts of salvia miltiorrhiza and 7 parts of ginger.
A preparation method of a traditional Chinese medicine composition for treating Parkinson's disease is characterized by comprising the following steps:
the method comprises the following steps: weighing the following raw materials in parts by weight: 20g of rhizoma anemarrhenae, 15g of cistanche, 18g of dogwood, 12g of ligusticum wallichii, 18g of polygala tenuifolia, 25g of rhizoma acori graminei, 3g of leech, 18g of salvia miltiorrhiza and 5g of ginger;
step two: grinding rhizoma anemarrhenae, Cistanchis herba, Corni fructus, rhizoma Ligustici Chuanxiong, cortex et radix Polygalae, rhizoma Acori Graminei, Hirudo, Saviae Miltiorrhizae radix and rhizoma Zingiberis recens into powder and sieving;
step three: weighing 5-12 times of water by weight of the medicine, adding the water into the prepared medicine, decocting rhizoma anemarrhenae, herba cistanches, dogwood, rhizoma ligustici wallichii, polygala tenuifolia and leech for 0.5-2.5 hours, then adding the salvia miltiorrhiza and the ginger, decocting for 0.5-2.5 hours, finally adding the rhizoma acori graminei, decocting for 0.5-1.5 hours, filtering out medicine juice, adding the water by weight of 6-10 times of the raw material medicine, decocting for 0.5-2.5 hours, filtering out the medicine juice, combining the medicine juice obtained in two times, concentrating, taking and washing the precipitate to obtain an effective component precipitate, and drying the effective component precipitate for later use.
A preparation method of a traditional Chinese medicine composition for treating Parkinson's disease comprises the steps of preparing 20g of rhizoma anemarrhenae, 15g of cistanche, 18g of dogwood, 12g of ligusticum wallichii, 18g of polygala tenuifolia, 25g of rhizoma acori graminei, 3g of leech, 18g of salvia miltiorrhiza and 5g of ginger, and decocting by a traditional Chinese medicine conventional method.
The application of the traditional Chinese medicine composition in preparing medicines for treating Parkinson's disease.
The invention is realized based on the following pharmacology: corni fructus has effects of treating enuresis, frequent micturition, metrorrhagia, leukorrhagia, apocrine sweat, internal heat, and diabetes, Cistanchis herba has effects of regulating endocrine, promoting metabolism and strengthening body, and has effects of invigorating kidney and promoting blood circulation, rhizoma Ligustici Chuanxiong has effects of treating epilepsia, phlegm syncope and fever unconsciousness, rhizoma anemarrhenae has effects of clearing heat and purging fire, and nourishing yin and moistening dryness, and can be used for treating fever polydipsia, lung heat and dry cough, bone steaming hectic fever, internal heat, diabetes, intestine dryness and constipation, and rhizoma Ligustici Chuanxiong has obvious tranquilizing effect on central nervous system. A small amount of rhizoma Ligustici Chuanxiong volatile oil can inhibit animal brain activity, and excite brain-extending respiratory center, vasomotor center and spinal cord reflex center, and cortex et radix Polygalae contains plant saponin, and can stimulate gastric mucosa to cause mild nausea, so as to increase bronchial secretion in reflexive manner to eliminate phlegm, and has effects of tranquilizing mind, improving intelligence, and resolving stagnation. For palpitation, amnesia, nocturnal emission, insomnia, cough with excessive phlegm, carbuncle, cellulitis, sore and swelling, rhizoma Acori Graminei is effective in eliminating dampness and promoting appetite, inducing resuscitation and eliminating phlegm, refreshing mind and improving intelligence. Can be used for treating epigastric fullness, inappetence, dysentery, coma, epilepsy, amnesia, and deafness. Regulating qi, promoting blood circulation, dispelling pathogenic wind, and removing dampness. For epilepsy, phlegm syncope, fever unconsciousness, amnesia, qi block, deafness, vexation in chest, stomachache, abdominal pain, arthralgia due to wind-cold-dampness, superficial infection and toxic swelling, red sage root has the functions of promoting blood circulation, removing blood stasis, dredging channels, relieving pain, clearing away heart-fire, relieving restlessness, cooling blood and resolving carbuncle. Can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain.
In the technical scheme, the invention provides the following technical effects and advantages:
the traditional Chinese medicine composition has the effects of tonifying kidney, activating blood, inducing resuscitation and dredging collaterals, has a good treatment effect on symptoms of muscle rigidity, action retardation, speech disability, muscle tremor, insomnia, constipation and the like of patients, can exert the drug effect to the maximum extent, enables the patients to obtain good treatment, has a remarkable treatment effect, is suitable for long-term administration, and has a good application prospect.
Detailed Description
The present invention will be described in further detail below in order to enable those skilled in the art to better understand the technical solution of the present invention.
Example 1:
the invention provides a preparation method of a traditional Chinese medicine composition for treating Parkinson's disease, which comprises 20g of rhizoma anemarrhenae, 15g of cistanche, 18g of dogwood, 12g of ligusticum wallichii, 18g of polygala tenuifolia, 25g of rhizoma acori graminei, 3g of leech, 18g of salvia miltiorrhiza and 5g of ginger.
Weighing 8 times of water by weight of the medicine, adding the water into the prepared medicine, decocting rhizoma anemarrhenae, herba cistanches, dogwood, rhizoma ligustici wallichii, polygala tenuifolia and leech for 1 hour, then adding the radix salviae miltiorrhizae and ginger, decocting for 1 hour, finally adding the rhizoma acori graminei, decocting for 1 hour, filtering out medicine juice, adding 1 time of water by weight of the raw material medicine, decocting for 1 hour, filtering out the medicine juice, combining the medicine juice obtained in two times, concentrating, taking and washing the precipitate to obtain the effective component precipitate, and drying the precipitate for later use.
Example 2: 15g of rhizoma anemarrhenae, 15g of cistanche, 15g of dogwood, 10g of ligusticum wallichii, 15g of polygala tenuifolia, 22g of rhizoma acori graminei, 2g of leech, 15g of salvia miltiorrhiza and 3g of ginger.
Weighing 8 times of water by weight of the medicine, adding the water into the prepared medicine, decocting rhizoma anemarrhenae, herba cistanches, dogwood, rhizoma ligustici wallichii, polygala tenuifolia and leech for 1 hour, then adding the radix salviae miltiorrhizae and ginger, decocting for 1 hour, finally adding the rhizoma acori graminei, decocting for 1 hour, filtering out medicine juice, adding 1 time of water by weight of the raw material medicine, decocting for 1 hour, filtering out the medicine juice, combining the medicine juice obtained in two times, concentrating, taking and washing the precipitate to obtain the effective component precipitate, and drying the precipitate for later use.
Example 3: 25g of rhizoma anemarrhenae, 25g of cistanche, 22g of dogwood, 15g of ligusticum wallichii, 25g of polygala tenuifolia, 30g of rhizoma acori graminei, 5g of leech, 25g of salvia miltiorrhiza and 8g of ginger.
Weighing 8 times of water by weight of the medicine, adding the water into the prepared medicine, decocting rhizoma anemarrhenae, herba cistanches, dogwood, rhizoma ligustici wallichii, polygala tenuifolia and leech for 1 hour, then adding the radix salviae miltiorrhizae and ginger, decocting for 1 hour, finally adding the rhizoma acori graminei, decocting for 1 hour, filtering out medicine juice, adding 1 time of water by weight of the raw material medicine, decocting for 1 hour, filtering out the medicine juice, combining the medicine juice obtained in two times, concentrating, taking and washing the precipitate to obtain the effective component precipitate, and drying the precipitate for later use.
Example 4: 18g of rhizoma anemarrhenae, 18g of cistanche, 20g of dogwood, 13g of ligusticum wallichii, 20g of polygala tenuifolia, 27g of rhizoma acori graminei, 4g of leech, 20g of salvia miltiorrhiza and 6g of ginger.
Weighing 8 times of water by weight of the medicine, adding the water into the prepared medicine, decocting rhizoma anemarrhenae, herba cistanches, dogwood, rhizoma ligustici wallichii, polygala tenuifolia and leech for 1 hour, then adding the radix salviae miltiorrhizae and ginger, decocting for 1 hour, finally adding the rhizoma acori graminei, decocting for 1 hour, filtering out medicine juice, adding 1 time of water by weight of the raw material medicine, decocting for 1 hour, filtering out the medicine juice, combining the medicine juice obtained in two times, concentrating, taking and washing the precipitate to obtain the effective component precipitate, and drying the precipitate for later use.
Example 5: 24g of rhizoma anemarrhenae, 24g of cistanche, 21g of dogwood, 14g of ligusticum wallichii, 23g of polygala tenuifolia, 28g of rhizoma acori graminei, 4g of leech, 23g of salvia miltiorrhiza and 7g of ginger.
Weighing 8 times of water by weight of the medicine, adding the water into the prepared medicine, decocting rhizoma anemarrhenae, herba cistanches, dogwood, rhizoma ligustici wallichii, polygala tenuifolia and leech for 1 hour, then adding the radix salviae miltiorrhizae and ginger, decocting for 1 hour, finally adding the rhizoma acori graminei, decocting for 1 hour, filtering out medicine juice, adding 1 time of water by weight of the raw material medicine, decocting for 1 hour, filtering out the medicine juice, combining the medicine juice obtained in two times, concentrating, taking and washing the precipitate to obtain the effective component precipitate, and drying the precipitate for later use.
Example 6: 20g of rhizoma anemarrhenae, 15g of cistanche, 18g of dogwood, 12g of ligusticum wallichii, 18g of polygala tenuifolia, 25g of rhizoma acori graminei, 3g of leech, 18g of salvia miltiorrhiza and 5g of ginger.
Weighing 8 times of water by weight of the medicine, adding the water into the prepared medicine, decocting rhizoma anemarrhenae, herba cistanches, dogwood, rhizoma ligustici wallichii, polygala tenuifolia and leech for 2 hours, then adding the radix salviae miltiorrhizae and the ginger, decocting for 2 hours, finally adding the rhizoma acori graminei, decocting for 2 hours, filtering out medicine juice, adding 1 time of water by weight of the raw material medicine, decocting for 2 hours, filtering out the medicine juice, combining the medicine juice obtained in two times, concentrating, taking and washing the precipitate to obtain the effective component precipitate, and drying the precipitate for later use.
Example 7: 15g of rhizoma anemarrhenae, 15g of cistanche, 15g of dogwood, 10g of ligusticum wallichii, 15g of polygala tenuifolia, 22g of rhizoma acori graminei, 2g of leech, 15g of salvia miltiorrhiza and 3g of ginger.
Weighing 8 times of water by weight of the medicine, adding the water into the prepared medicine, decocting rhizoma anemarrhenae, herba cistanches, dogwood, rhizoma ligustici wallichii, polygala tenuifolia and leech for 2 hours, then adding the radix salviae miltiorrhizae and the ginger, decocting for 2 hours, finally adding the rhizoma acori graminei, decocting for 2 hours, filtering out medicine juice, adding 1 time of water by weight of the raw material medicine, decocting for 2 hours, filtering out the medicine juice, combining the medicine juice obtained in two times, concentrating, taking and washing the precipitate to obtain the effective component precipitate, and drying the precipitate for later use.
Example 8: 25g of rhizoma anemarrhenae, 25g of cistanche, 22g of dogwood, 15g of ligusticum wallichii, 25g of polygala tenuifolia, 30g of rhizoma acori graminei, 5g of leech, 25g of salvia miltiorrhiza and 8g of ginger.
Weighing 8 times of water by weight of the medicine, adding the water into the prepared medicine, decocting rhizoma anemarrhenae, herba cistanches, dogwood, rhizoma ligustici wallichii, polygala tenuifolia and leech for 2 hours, then adding the radix salviae miltiorrhizae and the ginger, decocting for 2 hours, finally adding the rhizoma acori graminei, decocting for 2 hours, filtering out medicine juice, adding 1 time of water by weight of the raw material medicine, decocting for 2 hours, filtering out the medicine juice, combining the medicine juice obtained in two times, concentrating, taking and washing the precipitate to obtain the effective component precipitate, and drying the precipitate for later use.
Example 9: 18g of rhizoma anemarrhenae, 18g of cistanche, 20g of dogwood, 13g of ligusticum wallichii, 20g of polygala tenuifolia, 27g of rhizoma acori graminei, 4g of leech, 20g of salvia miltiorrhiza and 6g of ginger.
Weighing 8 times of water by weight of the medicine, adding the water into the prepared medicine, decocting rhizoma anemarrhenae, herba cistanches, dogwood, rhizoma ligustici wallichii, polygala tenuifolia and leech for 2 hours, then adding the radix salviae miltiorrhizae and the ginger, decocting for 2 hours, finally adding the rhizoma acori graminei, decocting for 2 hours, filtering out medicine juice, adding 1 time of water by weight of the raw material medicine, decocting for 2 hours, filtering out the medicine juice, combining the medicine juice obtained in two times, concentrating, taking and washing the precipitate to obtain the effective component precipitate, and drying the precipitate for later use.
Example 10: 24g of rhizoma anemarrhenae, 24g of cistanche, 21g of dogwood, 14g of ligusticum wallichii, 23g of polygala tenuifolia, 28g of rhizoma acori graminei, 4g of leech, 23g of salvia miltiorrhiza and 7g of ginger.
Weighing 8 times of water by weight of the medicine, adding the water into the prepared medicine, decocting rhizoma anemarrhenae, herba cistanches, dogwood, rhizoma ligustici wallichii, polygala tenuifolia and leech for 2 hours, then adding the radix salviae miltiorrhizae and the ginger, decocting for 2 hours, finally adding the rhizoma acori graminei, decocting for 2 hours, filtering out medicine juice, adding 1 time of water by weight of the raw material medicine, decocting for 2 hours, filtering out the medicine juice, combining the medicine juice obtained in two times, concentrating, taking and washing the precipitate to obtain the effective component precipitate, and drying the precipitate for later use.
Example 10: the traditional medicine is adopted for treatment.
In comparison with examples 1-5, the patients in 26 of 30 patients were controlled and significantly improved by taking the drug ratio of example 1, and no obvious complications were detected after treatment, and the patients had good renal function and no epilepsy or syncope.
Comparative examples 2 and 6, 30 of the patients tested had controlled disease in 27 of the patients; the disease conditions of 28 patients in 30 groups of patients in comparative examples 1, 5 and 30 groups of patients in test are controlled, and the disease conditions of 27 patients in 30 groups of patients in comparative examples 3, 7 and 30 groups of patients in test are controlled, so that the drug effect can be exerted to the maximum extent by adopting the decoction mode of example 6 under the condition of the same drug ratio, and the patients can be well cured.
Comparing examples 6 and 11, in experimental group 11 treated with conventional drugs, only 24 patients had their disease status controlled, which is a big difference from example 6, so that the drug efficacy of the drug can be maximized by using the drug ratio of example 1 in combination with the decoction method of example 6.
The following table is obtained according to examples 1 to 3:
| number of test sets | Is remarkably advanced | Progress of the technology | Invalidation | |
| Example 1 | 30 | 27 | 2 | 1 |
| Example 2 | 30 | 26 | 3 | 1 |
| Example 3 | 30 | 22 | 2 | 6 |
| Example 4 | 30 | 27 | 2 | 1 |
| Example 5 | 30 | 27 | 2 | 1 |
| Example 6 | 30 | 28 | 1 | 1 |
| Example 7 | 30 | 25 | 4 | 1 |
| Example 8 | 30 | 25 | 3 | 2 |
| Example 9 | 30 | 26 | 2 | 2 |
| Example 10 | 30 | 24 | 3 | 3 |
| Example 11 | 30 | 24 | 4 | 2 |
As can be seen from the above table, the proportion of the drugs in example 6 is moderate, and the patients' conditions are controlled by combining the decoction method in example 6, and no obvious complications are seen during the rehabilitation period.
While certain exemplary embodiments of the present invention have been described above by way of illustration only, it will be apparent to those of ordinary skill in the art that the described embodiments may be modified in various different ways without departing from the spirit and scope of the invention. Therefore, the above description is illustrative in nature and should not be construed as limiting the scope of the invention, which is defined by the appended claims, and any modifications, equivalents, improvements and the like, which come within the spirit and scope of the invention are intended to be embraced therein.
Claims (9)
1. A traditional Chinese medicine composition for treating Parkinson's disease is characterized in that: the used main materials comprise the following components in parts by weight: 15-25 parts of rhizoma anemarrhenae, 15-25 parts of cistanche, 15-22 parts of dogwood, 10-15 parts of ligusticum wallichii, 15-25 parts of polygala tenuifolia, 22-30 parts of rhizoma acori graminei, 2-5 parts of leech, 15-25 parts of salvia miltiorrhiza and 3-8 parts of ginger.
2. The traditional Chinese medicine composition for treating Parkinson's disease according to claim 1, which is characterized in that: 20 parts of rhizoma anemarrhenae, 15 parts of cistanche, 18 parts of dogwood, 12 parts of ligusticum wallichii, 18 parts of polygala tenuifolia, 25 parts of rhizoma acori graminei, 3 parts of leech, 18 parts of salvia miltiorrhiza and 5 parts of ginger.
3. The traditional Chinese medicine composition for treating Parkinson's disease according to claim 1, which is characterized in that: 15 parts of rhizoma anemarrhenae, 15 parts of cistanche, 15 parts of dogwood, 10 parts of ligusticum wallichii, 15 parts of polygala tenuifolia, 22 parts of rhizoma acori graminei, 2 parts of leech, 15 parts of salvia miltiorrhiza and 3 parts of ginger.
4. The traditional Chinese medicine composition for treating Parkinson's disease according to claim 1, which is characterized in that: 25 parts of rhizoma anemarrhenae, 25 parts of cistanche, 22 parts of dogwood, 15 parts of ligusticum wallichii, 25 parts of polygala tenuifolia, 30 parts of rhizoma acori graminei, 5 parts of leech, 25 parts of salvia miltiorrhiza and 8 parts of ginger.
5. The traditional Chinese medicine composition for treating Parkinson's disease according to claim 1, which is characterized in that: 18 parts of rhizoma anemarrhenae, 18 parts of cistanche, 20 parts of dogwood, 13 parts of ligusticum wallichii, 20 parts of polygala tenuifolia, 27 parts of rhizoma acori graminei, 4 parts of leech, 20 parts of salvia miltiorrhiza and 6 parts of ginger.
6. The traditional Chinese medicine composition for treating Parkinson's disease according to claim 1, which is characterized in that: 24 parts of rhizoma anemarrhenae, 24 parts of cistanche, 21 parts of dogwood, 14 parts of ligusticum wallichii, 23 parts of polygala tenuifolia, 28 parts of rhizoma acori graminei, 4 parts of leech, 23 parts of salvia miltiorrhiza and 7 parts of ginger.
7. The preparation method of the traditional Chinese medicine composition for treating Parkinson's disease according to any one of claims 1 to 5, which is characterized in that:
the method comprises the following steps: weighing the following raw materials in parts by weight: 20g of rhizoma anemarrhenae, 15g of cistanche, 18g of dogwood, 12g of ligusticum wallichii, 18g of polygala tenuifolia, 25g of rhizoma acori graminei, 3g of leech, 18g of salvia miltiorrhiza and 5g of ginger;
step two: grinding rhizoma anemarrhenae, Cistanchis herba, Corni fructus, rhizoma Ligustici Chuanxiong, cortex et radix Polygalae, rhizoma Acori Graminei, Hirudo, Saviae Miltiorrhizae radix and rhizoma Zingiberis recens into powder and sieving;
step three: weighing 5-12 times of water by weight of the medicine, adding the water into the prepared medicine, decocting rhizoma anemarrhenae, herba cistanches, dogwood, rhizoma ligustici wallichii, polygala tenuifolia and leech for 0.5-2.5 hours, then adding the salvia miltiorrhiza and the ginger, decocting for 0.5-2.5 hours, finally adding the rhizoma acori graminei, decocting for 0.5-1.5 hours, filtering out medicine juice, adding the water by weight of 6-10 times of the raw material medicine, decocting for 0.5-2.5 hours, filtering out the medicine juice, combining the medicine juice obtained in two times, concentrating, taking and washing the precipitate to obtain an effective component precipitate, and drying the effective component precipitate for later use.
8. A preparation method of a traditional Chinese medicine composition for treating Parkinson's disease is characterized by comprising the following steps: the preparation method comprises the steps of preparing 20g of rhizoma anemarrhenae, 15g of cistanche, 18g of dogwood, 12g of ligusticum wallichii, 18g of polygala tenuifolia, 25g of rhizoma acori graminei, 3g of leech, 18g of salvia miltiorrhiza and 5g of ginger, and decocting the components by a conventional traditional Chinese medicine method.
9. Use of a Chinese medicinal composition according to any one of claims 1-7 in the manufacture of a medicament for the treatment of parkinson's disease.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239597A (en) * | 2012-02-13 | 2013-08-14 | 杨明会 | Method for preparing traditional Chinese medicine composition for treatment of parkinson's disease |
| CN104435465A (en) * | 2014-11-19 | 2015-03-25 | 福建中医药大学 | Traditional Chinese medicine composition for treating parkinson disease |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239597A (en) * | 2012-02-13 | 2013-08-14 | 杨明会 | Method for preparing traditional Chinese medicine composition for treatment of parkinson's disease |
| CN104435465A (en) * | 2014-11-19 | 2015-03-25 | 福建中医药大学 | Traditional Chinese medicine composition for treating parkinson disease |
Non-Patent Citations (1)
| Title |
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| 窦永起等: "中西医结合治疗帕金森病疗效的对照观察", 《中国临床康复》 * |
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