CN110898157A - Application of traditional Chinese medicine composition in preparation of medicine for treating cervical spondylosis - Google Patents

Abstract

The invention discloses application of a traditional Chinese medicine composition in preparation of a medicine for treating cervical spondylosis, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following medicinal materials: radix Ophiopogonis, herba Schizonepetae, herba Lycopodii, herba Sidae Rhombifoliae, Notopterygii rhizoma, Notoginseng radix, Eucommiae cortex, rhizoma Ligustici Chuanxiong, Alismatis rhizoma, pericarpium Citri Tangerinae and Glycyrrhrizae radix. The traditional Chinese medicine composition prepared by the invention has obvious curative effect on treating cervical spondylosis, has small toxic and side effect, can dredge channels and promote qi and blood circulation, and has better health care and treatment effects on the cervical spondylosis.

Description

Application of traditional Chinese medicine composition in preparation of medicine for treating cervical spondylosis

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and relates to a method for preparing a traditional Chinese medicine composition for treating cervical spondylosis.

Background

Cervical spondylosis is a degenerative disease, which refers to progressive degeneration that begins with single or multiple cervical discs and results in structural changes of the surrounding bone and soft tissues, thereby affecting associated complications of blood vessels, nerve roots or (and) spinal cord. The degeneration of cervical intervertebral disc is the root cause of the occurrence and development of cervical spondylosis and the cervical spondylosis with imbalance of dynamic and static forces

The animal model destroys the muscles and ligaments at the back of the neck, and makes the static system lose the original balance, resulting in the degeneration of the cervical intervertebral disc. In the occurrence and development of cervical spondylosis, chronic strain is the chief culprit, and long-term damage to local muscles, ligaments and joint capsules can cause local bleeding and edema, inflammation changes, inflammation organization gradually appears at the diseased part, and hyperosteogeny is formed to influence local nerves and blood vessels.

In addition, related studies indicate that the main pathological mechanism of cervical spondylosis is "blood stasis". Fatigue can lead to obstruction, pain due to obstruction, blood stasis and obstruction, and failure of qi and blood to nourish the tendons and vessels, pain due to debility, so patients with cervical spondylosis often have blood stasis syndrome such as neck, shoulder and back pain, numbness of limbs, dark tongue, wiry pulse, etc. Research shows that both blood stasis and head lowering can cause tissue blood flow to reduce tissue congestion and edema, the blood stasis and the tissue change of the head lowering are more obvious, the blood flow reduction is positively correlated with cervical spondylosis, and the local blood flow reduction (blood stasis) of the cervical vertebra is considered to be an important reason and a main link for the cervical spondylosis.

At present, the treatment of cervical spondylosis mainly comprises two types of operation treatment and non-operation treatment, and the operation treatment has the defects of high treatment cost, difficult treatment of symptoms and root causes and easy relapse, which is not the first choice of patients with cervical spondylosis. In fact, most cervical spondylosis can be cured or obviously improved by non-operative treatment. The non-operative therapy comprises Chinese and western medicines, acupuncture, massage, physiotherapy, traction and other methods, and the medicines for treating cervical spondylosis comprise western medicines and Chinese medicines. Western medicines for treating cervical spondylosis are mainly non-steroidal analgesics mainly for diminishing inflammation and relieving pain, such as chondroitin sulfate A, vitamin E, cervicodynia and the like, and generally have quick response but have hard to last effect and need to be taken for a long time; most of the traditional Chinese medicines for treating cervical spondylosis on the market at present have poor clinical effect and slow drug effect.

There are many patents for the invention for treating cervical spondylosis, such as: the Chinese patent application 201410375462.1 discloses a Chinese medicinal composition for treating cervical spondylosis, which comprises the following preparation raw materials: astragalus root, licorice root, bupleurum root, ephedra, hemlock parsley, suberect spatholobus stem, safflower, bunge auriculate root, Chinese angelica, pseudo-ginseng, kudzu-vine root, white paeony root, incised notopterygium rhizome, amur corktree bark, pilose asiabell root, frankincense, clove, cassia bark, turmeric, divaricate saposhnikovia root, mustard seed, doubleteeth pubescent angelica root, crinis carbonisatus, nux vomica, ephedra, dahurian. The traditional Chinese medicine composition has more than thirty formulas and very complex components; and contains a plurality of rare Chinese herbal medicines such as radix cynanchi bungei, ephedra herb and the like, so that the cost of the Chinese medicinal composition is greatly increased.

Disclosure of Invention

The technical problem to be solved by the invention is to provide the traditional Chinese medicine composition for treating the cervical spondylosis and the preparation method thereof, so that the traditional Chinese medicine composition fully exerts the conditioning effect of the traditional Chinese medicine, has a remarkable treatment effect on the cervical spondylosis, and is prepared into a convenient and easy-to-use finished product preparation, so that the traditional Chinese medicine composition can adapt to the rhythm of modern life.

In order to realize the purpose of the invention, the technical scheme is as follows:

a traditional Chinese medicine composition for treating cervical spondylosis is prepared from the following medicinal materials in parts by weight: 10-20 parts of radix ophiopogonis, 8-20 parts of schizonepeta, 10-20 parts of lycopodium clavatum, 8-18 parts of sargentgloryvine stem, 8-16 parts of notopterygium root, 8-16 parts of pseudo-ginseng, 6-14 parts of eucommia bark, 8-14 parts of ligusticum wallichii, 6-14 parts of rhizoma alismatis, 4-8 parts of dried orange peel and 2-8 parts of liquorice.

Within the range of the weight portion, 3 formulas with obvious curative effect are preferably selected:

formula 1: 10 parts of dwarf lilyturf tuber, 8 parts of fineleaf schizonepeta herb, 10 parts of common clubmoss herb, 8 parts of saddle vine, 8 parts of incised notopterygium rhizome, 8 parts of pseudo-ginseng, 6 parts of eucommia bark, 8 parts of szechuan lovage rhizome, 6 parts of oriental waterplantain rhizome, 4 parts of tangerine peel and 2 parts of liquoric root.

And (2) formula: 20 parts of radix ophiopogonis, 20 parts of schizonepeta, 20 parts of lycopodium clavatum, 18 parts of sargentgloryvine stem, 16 parts of notopterygium root, 16 parts of pseudo-ginseng, 14 parts of eucommia bark, 14 parts of ligusticum wallichii, 14 parts of rhizoma alismatis, 8 parts of dried orange peel and 8 parts of liquorice.

And (3) formula: 15 parts of dwarf lilyturf tuber, 14 parts of fineleaf schizonepeta herb, 14 parts of common clubmoss herb, 14 parts of saddle vine, 12 parts of incised notopterygium rhizome, 12 parts of pseudo-ginseng, 10 parts of eucommia bark, 10 parts of szechuan lovage rhizome, 10 parts of oriental waterplantain rhizome, 6 parts of tangerine peel and 5 parts of liquoric root.

Correspondingly, the invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:

(1): cleaning radix Ophiopogonis, drying, pulverizing, sieving with 60-80 mesh sieve, placing the obtained coarse powder in supercritical carbon dioxide extraction device, adding 30-45% by weight of 60-85% ethanol, regulating carbon dioxide flow at 15-20L/h, extracting under 15-20MPa at 40-60 deg.C for 1.5-2 hr, separating under reduced pressure to obtain radix Ophiopogonis extract, and retaining radix Ophiopogonis residue;

(2): respectively weighing herba Schizonepetae, herba Lycopodii, herba Sidae Rhombifoliae, Notopterygii rhizoma, Notoginseng radix, Eucommiae cortex, rhizoma Ligustici Chuanxiong, Alismatis rhizoma, pericarpium Citri Tangerinae and Glycyrrhrizae radix, removing impurities, cleaning, oven drying, slicing, and pulverizing into coarse powder;

(3): taking the coarse powder obtained in the step (2), combining the dwarf lilyturf tuber residues, adding water with the amount of 8-10 times of the total amount of the medicinal materials, soaking for 3-4 hours, decocting for 2-3 times, each time for 3-4 hours, filtering, retaining filter residues, combining filtrates, and concentrating the filtrate under vacuum and reduced pressure to a concentrated solution with the relative density of 1.05-1.15 measured at the temperature of 60 ℃ to obtain a water extraction concentrated solution;

(4): adding ethanol with volume fraction of 60-80% 8-10 times of the total amount of the medicinal materials into the filter residue in the step (3), extracting under reflux for 2-3 times, each time for 4-6 hours, filtering, mixing filtrates, vacuum concentrating the filtrate under reduced pressure to obtain concentrated solution with relative density of 1.05-1.15 at 60 deg.C, to obtain ethanol extract;

(5): mixing the radix Ophiopogonis extract, the water extract concentrate and the ethanol extract concentrate, vacuum drying, pulverizing, and sieving with 100-mesh sieve and 200-mesh sieve.

Further, the traditional Chinese medicine composition for treating cervical spondylosis can be prepared into tablets, pills, powder, granules or capsules.

The Chinese medicinal materials used in the Chinese medicinal formula have the following sources, properties, tastes, channels and efficacies:

radix ophiopogonis: the product is dried root tuber of Ophiopogon japonicus (Ophiopogon japonicus) of Liliaceae; sweet in taste, slightly bitter and slightly cold in nature; entering heart, lung and stomach meridians; nourish yin, promote the production of body fluid, moisten lung and clear away heart-fire.

Herba schizonepetae: the product is dried aerial parts of herba Schizonepetae of Labiatae; pungent taste and mild nature; entering lung and liver meridians; relieve exterior syndrome, dispel wind and promote eruption.

B, common clubmoss herb: the product is dried whole plant of Lycopodium clavatum L. Slightly bitter and pungent with warm nature; entering liver, spleen and kidney meridians; dispel wind and dampness, relax tendons and activate collaterals.

Saddle vine: the product is whole herb of Ipomoea batatas Lam of Ipomoea of Convolvulaceae. Pungent, slightly bitter and warm in nature; dispelling pathogenic wind, removing dampness, removing toxic substance, and relieving swelling.

Notopterygium root: the product is dried rhizome and root of Notopterygium incisum (back wing celery) of Umbelliferae. Pungent and bitter taste, warm nature; entering bladder and kidney meridians; dispelling cold, dispelling pathogenic wind, removing dampness, and relieving pain.

Pseudo-ginseng: the product is dried root of Panax notoginseng (Burk.) F.H.Chen of Araliaceae; sweet, slightly bitter and warm in nature; entering liver and stomach meridians; disperse blood stasis, stop bleeding, resolve swelling and alleviate pain.

Eucommia ulmoides: the product is dry bark of eucommia ulmoides Oliver of Eucommiaceae. Sweet taste and warm nature; entering liver and kidney meridians; tonify liver and kidney, strengthen tendons and bones, and prevent miscarriage.

Ligusticum wallichii: the product is dried rhizome of Umbelliferae plant rhizoma Ligustici Chuanxiong; pungent taste and warm nature; entering liver, gallbladder and pericardium; promote blood circulation and move qi, dispel wind and alleviate pain.

Rhizoma alismatis: the product is dried tuber of Alismatis rhizoma of Alismataceae; sweet taste and cold nature; entering kidney and bladder meridians; induce diuresis, clear damp-heat.

Dried orange peel: the product is dried mature pericarp of Citrus reticulata Blanco of Rutaceae and its cultivar; bitter and pungent taste, warm in nature; entering lung and spleen meridians; regulate qi to invigorate spleen, dry dampness and resolve phlegm.

Licorice root: the product is dried root of Glycyrrhiza uralensis Fisch of Leguminosae; sweet in taste and neutral in nature; entering heart, lung, spleen and stomach meridians; tonify spleen and qi, relieve spasm and alleviate pain, and harmonize the drugs.

The compatibility analysis of the traditional Chinese medicine composition comprises the following steps:

the traditional Chinese medicine composition takes the lycopodium clavatum and the sargentgloryvine stem as monarch drugs, and has the effects of dispelling wind and removing dampness, relaxing tendons and activating collaterals, and drawing out toxin and reducing swelling; radix ophiopogonis, schizonepeta, notopterygium root, pseudo-ginseng and eucommia ulmoides are used as ministerial drugs, and the effects of relieving exterior syndrome, dispelling wind, dissipating blood stasis, stopping bleeding, diminishing swelling and relieving pain are achieved; rhizoma ligustici wallichii, rhizoma alismatis and dried orange peel are used as adjuvant drugs, so that the effects of promoting blood circulation and promoting qi circulation, warming and dredging channels and collaterals and regulating qi and tonifying spleen are achieved; the liquorice is used as a guiding drug to tonify the spleen and qi, relieve spasm and pain and harmonize the property of the drugs. The medicines are matched, supplement each other and have synergistic effect, so that the traditional Chinese medicine composition has the effects of dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, relieving swelling and pain, warming and dredging channels and collaterals and the like, and has very obvious curative effect on treating cervical spondylosis.

Compared with the prior art, the traditional Chinese medicine composition has the following advantages:

1. the traditional Chinese medicine composition is prepared from pure natural Chinese herbal medicines, has synergistic effects, remarkably reduces adverse reactions and toxic and side effects, and has the treatment advantages of good curative effect, treatment of both symptoms and root causes, and side regulation;

2. pharmacodynamic test data show that the traditional Chinese medicine composition has more obvious effects of resisting inflammation and improving blood rheology parameters of blood stasis rats, which shows that the traditional Chinese medicine composition has obvious synergistic effect in treating cervical spondylosis and can obviously improve the symptoms of the cervical spondylosis;

3. the traditional Chinese medicine composition has the advantages of simple and easy preparation process, stable drug effect and easy popularization and application.

Therefore, the invention also claims the application of the traditional Chinese medicine composition in preparing a medicine for treating cervical spondylosis.

Detailed Description

The present invention will be further described with reference to specific examples, and it will be understood by those skilled in the art that other similar changes in the following examples may be made without departing from the spirit and scope of the invention to achieve similar results.

Example 1

The traditional Chinese medicine composition capsule in the embodiment 1 of the invention is prepared from the following medicinal materials in parts by weight: 10 parts of dwarf lilyturf tuber, 8 parts of fineleaf schizonepeta herb, 10 parts of common clubmoss herb, 8 parts of saddle vine, 8 parts of incised notopterygium rhizome, 8 parts of pseudo-ginseng, 6 parts of eucommia bark, 8 parts of szechuan lovage rhizome, 6 parts of oriental waterplantain rhizome, 4 parts of tangerine peel and 2 parts of liquoric root.

The preparation method comprises the following steps:

(1): cleaning radix Ophiopogonis, drying, pulverizing, sieving with 70 mesh sieve, placing the obtained coarse powder in a supercritical carbon dioxide extraction device, adding 80% ethanol 40% by volume of the coarse powder, regulating carbon dioxide flow at 18L/h, extracting at 20MPa and 50 deg.C for 2h, separating under reduced pressure to obtain radix Ophiopogonis extract, and retaining radix Ophiopogonis residue;

(2): respectively weighing herba Schizonepetae, herba Lycopodii, herba Sidae Rhombifoliae, Notopterygii rhizoma, Notoginseng radix, Eucommiae cortex, rhizoma Ligustici Chuanxiong, Alismatis rhizoma, pericarpium Citri Tangerinae and Glycyrrhrizae radix, removing impurities, cleaning, oven drying, slicing, and pulverizing into coarse powder;

(3): taking the coarse powder obtained in the step (2), combining the dwarf lilyturf tuber residues, adding water with the amount which is 10 times of the total amount of the medicinal materials, soaking for 3 hours, decocting for 3 times, decocting for 3 hours each time, filtering and retaining filter residues, combining filtrates, and concentrating the filtrates under vacuum and reduced pressure to a concentrated solution with the relative density of 1.05-1.15 measured at the temperature of 60 ℃ to obtain a water extraction concentrated solution;

(4): adding ethanol with the volume fraction of 70% which is 8 times the total amount of the medicinal materials into the filter residue in the step (3), performing reflux extraction for 3 times, each time for 6 hours, filtering, combining the filtrates, and performing vacuum concentration on the filtrate under reduced pressure to obtain a concentrated solution with the relative density of 1.05-1.15 measured at 60 ℃ to obtain an ethanol extraction concentrated solution;

(5): mixing radix Ophiopogonis extract, water extract concentrate and ethanol extract concentrate, vacuum drying, pulverizing, and sieving with 100 mesh sieve to obtain Chinese medicinal fine powder;

(6): adding appropriate adjuvants into the Chinese medicinal fine powder obtained in step (5), and making into capsule by modern general preparation technology.

Example 2

The traditional Chinese medicine composition capsule in the embodiment 2 of the invention is prepared from the following medicinal materials in parts by weight: 20 parts of radix ophiopogonis, 20 parts of schizonepeta, 20 parts of lycopodium clavatum, 18 parts of sargentgloryvine stem, 16 parts of notopterygium root, 16 parts of pseudo-ginseng, 14 parts of eucommia bark, 14 parts of ligusticum wallichii, 14 parts of rhizoma alismatis, 8 parts of dried orange peel and 8 parts of liquorice.

The preparation method is the same as example 1.

Example 3

The traditional Chinese medicine composition capsule in the embodiment 3 of the invention is prepared from the following medicinal materials in parts by weight: 15 parts of dwarf lilyturf tuber, 14 parts of fineleaf schizonepeta herb, 14 parts of common clubmoss herb, 14 parts of saddle vine, 12 parts of incised notopterygium rhizome, 12 parts of pseudo-ginseng, 10 parts of eucommia bark, 10 parts of szechuan lovage rhizome, 10 parts of oriental waterplantain rhizome, 6 parts of tangerine peel and 5 parts of liquoric root.

The preparation method is the same as example 1.

Pharmacodynamic study:

test example 1: the traditional Chinese medicine composition has the effect on mouse ear swelling caused by dimethylbenzene

1. Experimental methods

Taking 120 healthy Kunming mice with the body weight of 22-26g, the age of 8-12 weeks, and the sex of each half, randomly dividing the mice into 12 groups, wherein each group comprises 10 mice: a normal group, a model group, a Zhengtian pill positive drug control group (Huarun sanjiu medicine, ltd.), and high, medium and low dose groups of the traditional Chinese medicine capsules prepared in the embodiments 1, 2 and 3 of the present invention. The administration dose of the high, middle and low dose groups is respectively 8g/Kg, 4g/Kg and 2 g/Kg; the administration dose of the positive drug control group is 8g/Kg, the stomach is irrigated for 1 time every day, the administration is continuously carried out for 1 month, xylene (0.05 mL/mouse) is evenly smeared on the right ear of the mouse after the last administration is carried out for 60min to cause ear swelling, the thickness (mum) of the bilateral ear of the mouse is measured and recorded by a thickness gauge after the administration is carried out for 2h, and the ear swelling value (mum) is equal to the thickness of the right ear-the thickness of the left ear.

As a result, the degree of ear swelling of mice in the model group after being treated by the dimethylbenzene is greatly increased (P < 0.001), so that the anti-inflammatory effect of the traditional Chinese medicine composition can be tested by using the dimethylbenzene-treated ear swelling model. Compared with a model group, the high, medium and low dose groups and the positive drug control group of the traditional Chinese medicine composition in the embodiment 1, the embodiment 2 and the embodiment 3 have obvious treatment effects (P is less than 0.05), wherein after the high dose group of the traditional Chinese medicine composition is treated, the ear swelling of the mouse basically returns to a normal level, and the effect of complete cure is achieved; the treatment effect of the traditional Chinese medicine composition with high dose is better than that of a positive control medicament (P is less than 0.05), which shows that the traditional Chinese medicine composition has obvious anti-inflammatory effect and can fundamentally relieve the inflammation condition of a patient when being used for treating cervical spondylosis.

Test example 2: the traditional Chinese medicine composition of the invention has the function of improving a rat blood stasis model

1. Experimental methods

Healthy Wistar rats with the weight of 200-: a normal group, a model group, a positive drug control group (Zhengtian pill, national standard Z44020711, Huarun Sanjiu medicine GmbH), and high, medium and low dosage groups of the Chinese medicinal capsule prepared in the embodiments 1, 2 and 3 of the present invention. The administration dose of the high, middle and low dose groups is 4g/Kg, 2g/Kg and 1g/Kg respectively; the administration dose of the positive drug control group is 4 g/Kg; the normal control group and the model group were administered 0.5% CMC 2 times daily for 20 consecutive days. On the 20 th day of gavage, except for the normal control group, the animals in the other groups were injected with adrenaline hydrochloride subcutaneously at a rate of 1mg/Kg for 2 times per day at intervals of 4 hours, and after the first injection for 3 hours, the animals were placed in ice water at 4 ℃ for 15 min. On day 3 of the injection of epinephrine hydrochloride, 4-5ml of heparin is taken for anticoagulation determination of blood rheology parameters, and the liver is taken for weighing and the organ coefficient is converted.

The result shows that compared with a normal control, the whole blood high-cut index, the whole blood low-cut index, the erythrocyte aggregation index, the Kathon viscosity and the plasma viscosity of the model group are all obviously increased (P is less than 0.05), and the rat blood stasis model is successfully constructed. Compared with the model group, the low, medium and high dose groups and the positive control group of the drug tablets prepared in the example 1, the example 2 and the example 3 of the invention all reduce the whole blood high cut index, the whole blood low cut index, the erythrocyte aggregation index, the Kathon viscosity and the plasma viscosity remarkably or very remarkably after being applied, wherein the high dose has very remarkable difference (P < 0.01). Under the same experimental conditions, the treatment effect of the positive control drug is not as good as that of the high-dose group of the drug tablet.

Clinical curative effect observation of traditional Chinese medicine composition on cervical spondylosis clinical volunteer patients

1. Basic data:

selecting 400 clinical volunteer patients with cervical spondylosis, wherein the age is 20-55 years, the average age is 36 years, the longest course of disease is 8 years, and the shortest course of disease is 6 months; the disappearance or the back projection of the physiological lordosis of the cervical vertebra, the stenosis of the intervertebral space, the calcification of the ligamentum nuchae and other manifestations are proved by CT and X-ray pictures, patients may feel heavy, sour, swollen and stiff neck, accompanied by the sour and swollen weakness of one side of the upper limb, chronic attack cervical vertebra accompanied by the numbness and pain of the shoulder and the arm, or dizziness, blurred vision or morning face puffiness, arm swelling and the like. The treatment is divided into 4 groups, namely a control group, a treatment A group, a treatment B group and a treatment C group, wherein each group comprises 100 cases, and the groups have no great difference in age, sex and disease severity and have contrast.

2. The treatment method comprises the following steps:

control group: zhengtian pill (Huarun Sanjiu medicine, Inc.) is taken 2 times a day, 1 pill once, and 7 days as a treatment course for 4 treatment courses.

The capsules prepared in the examples 1, 2 and 3 of the invention are respectively taken for the treatment groups A, B and C, 2 capsules are taken 2 times a day, 7 days are a treatment course, and 4 treatment courses are total.

3. The curative effect standard is as follows:

and (3) healing: after the medicine is taken, various cervical spondylosis symptoms and physical signs disappear, the neck, shoulders and forearms are obviously and freely stretched and moved, the functions are recovered, the vision disorder and other symptoms disappear, and the disease does not relapse after 1 year follow-up visit;

the effect is shown: after the medicine is taken, the main symptoms and physical signs basically disappear, most functions are recovered, and the disease does not relapse after 1 year of follow-up visit;

the method has the following advantages: after the medicine is taken, the main symptoms are slightly relieved, the basic function is recovered, and the disease recurs in half a year after the medicine is stopped;

and (4) invalidation: symptoms and signs were unchanged before and after treatment.

The total effective rate is (cure number + significant number + effective number)/the total number of patients is multiplied by 100%.

4. The treatment results are as follows:

the cure rate of the traditional Chinese medicine composition prepared by the invention reaches 80%, the total effective rate reaches 85%, which is far higher than that of a control group, wherein the effect of treating group C, namely example 3, is the best, the cure rate is 84%, and the total effective rate reaches 93%. The traditional Chinese medicine composition prepared by the preparation method has unique advantages in treating cervical spondylosis, is safe and effective, and has clinical popularization value.

Claims (4)

1. The application of a traditional Chinese medicine composition in preparing a medicine for treating cervical spondylosis is characterized in that the traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 10-20 parts of radix ophiopogonis, 8-20 parts of schizonepeta, 10-20 parts of lycopodium clavatum, 8-18 parts of sargentgloryvine stem, 8-16 parts of notopterygium root, 8-16 parts of pseudo-ginseng, 6-14 parts of eucommia bark, 8-14 parts of ligusticum wallichii, 6-14 parts of rhizoma alismatis, 4-8 parts of dried orange peel and 2-8 parts of liquorice.

2. The application of claim 1, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10 parts of dwarf lilyturf tuber, 8 parts of fineleaf schizonepeta herb, 10 parts of common clubmoss herb, 8 parts of saddle vine, 8 parts of incised notopterygium rhizome, 8 parts of pseudo-ginseng, 6 parts of eucommia bark, 8 parts of szechuan lovage rhizome, 6 parts of oriental waterplantain rhizome, 4 parts of tangerine peel and 2 parts of liquoric root.

3. The application of claim 1, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20 parts of radix ophiopogonis, 20 parts of schizonepeta, 20 parts of lycopodium clavatum, 18 parts of sargentgloryvine stem, 16 parts of notopterygium root, 16 parts of pseudo-ginseng, 14 parts of eucommia bark, 14 parts of ligusticum wallichii, 14 parts of rhizoma alismatis, 8 parts of dried orange peel and 8 parts of liquorice.

4. The application of claim 1, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15 parts of dwarf lilyturf tuber, 14 parts of fineleaf schizonepeta herb, 14 parts of common clubmoss herb, 14 parts of saddle vine, 12 parts of incised notopterygium rhizome, 12 parts of pseudo-ginseng, 10 parts of eucommia bark, 10 parts of szechuan lovage rhizome, 10 parts of oriental waterplantain rhizome, 6 parts of tangerine peel and 5 parts of liquoric root.