CN112773739A - Antibacterial hand sanitizer and preparation method thereof - Google Patents
Antibacterial hand sanitizer and preparation method thereof Download PDFInfo
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- CN112773739A CN112773739A CN202110272935.5A CN202110272935A CN112773739A CN 112773739 A CN112773739 A CN 112773739A CN 202110272935 A CN202110272935 A CN 202110272935A CN 112773739 A CN112773739 A CN 112773739A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/49—Solubiliser, Solubilising system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Abstract
The invention provides an antibacterial hand sanitizer, which at least comprises the following preparation raw materials in parts by weight: 0.1-2 parts of natural plant extract, 0.05-0.5 part of water softener, 1-5 parts of organic base, 5-10 parts of organic acid, 1-5 parts of surfactant, 1-5 parts of solubilizer, 0.1-0.5 part of thickener, 0.1-2 parts of antibacterial agent and 70-90 parts of water; the invention adopts the vegetable oil fatty acid organic alkali salt as the main active ingredient for cleaning hands, and has the advantages of easy washing, convenient use and small irritation to the skin of the hands; meanwhile, the plant skin-care nourishing ingredients are added, so that the hand skin cleaning and degreasing skin-care and maintenance are facilitated.
Description
Technical Field
The invention relates to the technical field of daily chemical products, in particular to an antibacterial hand sanitizer and a preparation method thereof.
Background
Many things in daily life and work of people are completed by two hands, on one hand, the two hands are polluted by various stains and microorganisms after contacting various articles, on the other hand, some work needs to be completed in a clean environment, and the sanitation degree of the two hands is higher, so that the hand washing product needs to have at least two functions of decontamination and antibiosis.
The decontamination performance of the existing hand washing products is basically realized by adding a surfactant, the surfactant widely used in the hand washing products at present mainly comprises soaps, sulfates and amino acids, wherein the soaps have strong alkalinity and cause the problems of rough skin, chap and the like, and the amino acid products breed a large amount of microorganisms such as bacteria, fungi and the like in a humid environment for a long time. The sterilization performance of the hand washing product can be realized by adding bactericides, commonly used bactericides comprise alcohol, peracetic acid, sodium hypochlorite, bleaching extract, glutaraldehyde, triclosan, salicylic acid, p-chlororesorcinol, chlorhexidine acetate and the like, although the bactericides can kill bacteria, the bactericides have obvious defects such as toxicity, irritation, corrosivity, poor lasting effect, strong oxidizing property, peculiar smell and the like, and even some bactericides are limited to use. Therefore, the development of a novel antibacterial hand sanitizer and the addition of a nontoxic, nonirritating, noncorrosive, safe and efficient sterilization component become the key points of research and development of technicians in the field.
Disclosure of Invention
In order to solve the technical problems, the invention provides an antibacterial hand sanitizer, which is prepared from at least the following raw materials in parts by weight: 0.1-2 parts of natural plant extract, 0.05-0.5 part of water softener, 1-5 parts of organic base, 5-10 parts of organic acid, 1-5 parts of surfactant, 1-5 parts of solubilizer, 0.1-0.5 part of thickener, 0.1-2 parts of antibacterial agent and 70-90 parts of water.
As a preferred technical solution of the present invention, the natural plant extract is selected from one or more of seaweed extract, witch hazel extract, aloe, chamomile extract, green tea extract, licorice extract, and rhodiola extract.
As a preferable technical scheme of the invention, the extraction method of the witch hazel extract at least comprises the following steps: pulverizing Hamamelis mollis extract, adding isopropanol, extracting at 65-75 deg.C under reflux, filtering, adding hexane into the filtrate, separating, collecting the lower layer, and evaporating the solvent with rotary evaporator.
As a preferred technical solution of the present invention, the volume ratio of the isopropyl alcohol to the hexane is 1: (0.1-0.8).
As a preferable technical scheme of the invention, the water softener is selected from one or more of EDTA-4 sodium, sodium tripolyphosphate, sodium metaphosphate and trisodium phosphate.
As a preferred technical solution of the present invention, the organic base is selected from one or more of monoethanolamine, triethanolamine, and diethanolamine.
In a preferred embodiment of the present invention, the fatty acid is selected from one or more of coconut oil fatty acid, palm oil fatty acid, soybean oil fatty acid, rapeseed oil fatty acid, and peanut oil fatty acid.
As a preferable technical scheme of the invention, the surfactant is selected from one or more of cocamidopropyl betaine, amine oxide, alkyl glycoside and fatty alcohol-polyoxyethylene ether.
In a preferred embodiment of the present invention, the solubilizer is selected from one or more of glycerol, propylene glycol, polyethylene glycol, and polyglycerol.
In a second aspect, the invention provides a method for preparing an antibacterial hand sanitizer, which at least comprises the following steps:
1) adding water to the reactor;
2) adding a water softener and an organic base into a reactor, uniformly stirring, and heating to 40-50 ℃;
3) adding fatty acid into the reactor, stirring for 0.5-2 hours, and cooling to below 30 ℃ after the fatty acid is completely dissolved;
4) adding a surfactant into the reactor, and stirring for 10-30 minutes;
5) adding a solubilizer into the reactor, and stirring for 10-30 minutes;
6) adding a thickening agent into the reactor, and stirring for 10-30 minutes;
7) adding an antibacterial agent into the reactor, and stirring for 10-30 minutes;
8) adding skin care natural plant extract into the reactor, and stirring for 10-30 minutes;
9) stirring for 2 hours until the reaction materials are completely dissolved to be uniform; and (5) obtaining the product.
Compared with the prior art, the invention has the beneficial effects that:
1) the invention adopts the vegetable oil fatty acid organic alkali salt as the main active ingredient for cleaning hands, and has the advantages of easy washing, convenient use and small irritation to the skin of the hands;
2) the hand cream is added with plant skin-care nourishing ingredients, so that the hand cream is beneficial to skin care and maintenance after hand skin is cleaned and degreased;
3) the invention is simultaneously added with the antibacterial agent, which is beneficial to removing pathogenic microorganisms of hands and keeping human health.
Detailed Description
The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.
When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.
The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.
Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.
In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.
In order to solve the technical problems, the invention provides an antibacterial hand sanitizer in a first aspect, which is prepared from, by weight, at least 0.1-2 parts of natural plant extract, 0.05-0.5 part of water softener, 1-5 parts of organic base, 5-10 parts of organic acid, 1-5 parts of surfactant, 1-5 parts of solubilizer, 0.1-0.5 part of thickener, 0.1-2 parts of antibacterial agent and 70-90 parts of water.
In a more preferable embodiment, the antibacterial hand sanitizer provided by the invention is prepared from at least 1-1.6 parts by weight of natural plant extract, 0.1-0.4 part by weight of water softener, 2-4 parts by weight of organic base, 7-9 parts by weight of organic acid, 2-3.5 parts by weight of surfactant, 1.5-3 parts by weight of solubilizer, 0.2-0.4 part by weight of thickener, 0.5-1.6 parts by weight of antibacterial agent and 75-85 parts by weight of water.
In a most preferred embodiment, the antibacterial hand sanitizer provided by the invention is prepared from at least 1.3 parts by weight of natural plant extract, 0.3 part by weight of water softener, 2.4 parts by weight of organic base, 8 parts by weight of organic acid, 2.8 parts by weight of surfactant, 2 parts by weight of solubilizer, 0.3 part by weight of thickener, 0.8 part by weight of antibacterial agent and 80 parts by weight of water.
Natural plant extract
In a preferred embodiment, the natural plant extract of the present invention is selected from one or more of seaweed extract, witch hazel extract, aloe, chamomile extract, green tea extract, licorice extract, and rhodiola extract.
In a preferred embodiment, the natural plant extract of the present invention is a witch hazel extract.
The witch hazel (Hamamelis mollis Oliver) is named as Murraya koenigii, Calathea chinensis, Rosales, Hamamelidaceae, Hamamelidium deciduous shrub or small arbor, and the length of the Hamamelidium mollis Oliver is up to 8 m; the tender branches have star-shaped villi; eliminating old branch and baldness; the bud body is long and oval, wide and round, and the shape of the leaf is beautiful; leaves are opened before and after 2 months, flowers cluster leaves and axilla, the color is golden yellow, golden petals of the flowers are like a witches, dancing elegantly, coquettish and pluripotency, blossom in early spring, snow anger, and the shape is like a plum, so the plum is named; it is also known as honeysuckle flower due to its cold resistance.
Hamamelis virginiana is mostly grown in hillside, brook and broadleaf forest edge, and irrigated in clusters; the high mountain trees are vertically distributed at the elevation of 600-1600 m. The hamamelis virginiana is a warm ground tree species, has strong cold resistance and can grow in open air at the temperature of minus 15 ℃. It is pleased with light, but it is more resistant to yin in the early stage, and can grow under the condition of semi-yin. The sandy soil which has low requirements on soil, can grow in acid and neutral soil, is fertile, moist and loose and has good drainage property, and grows best.
In a preferred embodiment, the extraction method of the witch hazel extract at least comprises the following steps: pulverizing Hamamelis mollis extract, adding isopropanol, extracting at 65-75 deg.C under reflux, filtering, adding hexane into the filtrate, separating, collecting the lower layer, and evaporating the solvent with rotary evaporator.
In a preferred embodiment, the volume ratio of isopropanol to hexane in the present invention is 1: (0.1-0.8).
In a most preferred embodiment, the volume ratio of isopropanol to hexane in the present invention is 1: 0.3.
the witch hazel extract is added, so that the softness and the skin care capability of the antibacterial hand sanitizer are effectively improved; on one hand, the witch hazel extract prepared by the invention contains special allergy factors, so that the unstable skin can be relieved, the metabolic balance can be kept, and the discomfort of the skin can be eliminated; meanwhile, the witch hazel extract has special curative effect on fungal infection; on the other hand, the invention adopts a special extraction method, particularly adopts special extracting solutions, and controls the proportion of the extracting solutions, so that the invention reduces the proportion of unstable components in the witch hazel extract, thereby reducing the irritation of the witch hazel extract to the skin; the possible reason is that the polarity of the isopropanol is far greater than that of the hexane, and the isopropanol and the hexane are in a certain proportion, so that components with high polarity in the extract are more easily dissolved in the isopropanol, components with low polarity are easily dissolved in the hexane, when a solute is dissolved in a solvent, the distribution coefficient is influenced, a layering phenomenon occurs, substances causing skin irritation are easily dissolved in the hexane, the hexane is well separated, and the softness and the safety of the antibacterial hand sanitizer are improved.
Water softening agent
Some substances of the water softener have the function of complexing inorganic salt, and the salt in water is generated into a complex to be separated out, so that hard water is softened; substances having this function are called water softeners.
In a preferred embodiment, the water softener is selected from one or more of EDTA-4 sodium, sodium tripolyphosphate, sodium metaphosphate and trisodium phosphate.
In a preferred embodiment, the water softener of the present invention is sodium tripolyphosphate.
The sodium tripolyphosphate of the invention is an inorganic substance with a chemical formula of Na5P3O10Is an amorphous water-soluble linear polyphosphate with Na at both ends2PO4Stopping, wherein the molecular weight is 367.86, and the water retention agent has complexation effect on alkaline earth metal and heavy metal ions and can soften water; also has ion exchange capacity, can make suspension become solution, and has strong dispersibility。
Organic base
The organic base in the invention refers to an organic compound containing amino in the molecule.
In a preferred embodiment, the organic base according to the present invention is selected from one or more of monoethanolamine, triethanolamine, and diethanolamine.
In a preferred embodiment, the organic base of the present invention is triethanolamine.
The triethanolamine is an organic compound which can be regarded as a trihydroxy substituent of triethylamine and has a chemical formula of C6H15NO3(ii) a Similar to other amine compounds, because of the lone pair of electrons on the nitrogen atom, triethanolamine has weak alkalinity and can react with inorganic acid or organic acid to generate salt.
Organic acids
The organic acid in the invention refers to some organic compounds with acidity.
In a preferred embodiment, the organic acid of the present invention is a fatty acid.
In a preferred embodiment, the fatty acid according to the present invention is selected from one or more of coconut oil fatty acid, palm oil fatty acid, soybean oil fatty acid, rapeseed oil fatty acid, and peanut oil fatty acid.
In a most preferred embodiment, the fatty acid of the present invention is coconut oil fatty acid.
The main components of the coconut oil fatty acid comprise caprylic acid, capric acid, dodecanoic acid, tetradecanoic acid, hexadecanoic acid, octadecanoic acid and octadecenoic acid; the antibacterial hand sanitizer is easy to dissolve in water, has good functions of foaming, foam stabilization, penetration decontamination, hard water resistance and the like, can be compatible with various surfactants, and improves the antibacterial property of the antibacterial hand sanitizer.
Surface active agent
The surfactant is a surfactant which contains an ether group which is not dissociated in an aqueous solution as a main hydrophilic group in a molecule, and the surface activity of the surfactant is represented by neutral molecules. The surfactant has high surface activity, good solubilization, washing, antistatic, calcium soap dispersion and other performances, small irritation, and excellent wetting and washing functions. The pH value range of the ionic surfactant can be wider than that of the common ionic surfactant, and the ionic surfactant can be used together with other ionic surfactants, and the surface activity of the system can be improved by adding a small amount of the ionic surfactant.
In a preferred embodiment, the surfactant according to the present invention is selected from one or more of cocamidopropyl betaine, amine oxide, alkyl glycoside, fatty alcohol polyoxyethylene ether.
In a preferred embodiment, the surfactant of the present invention is cocamidopropyl betaine.
According to the invention, the amphoteric surfactant is added into the system, so that the dispersibility and stability of the plant extract in the system can be effectively improved; the amphoteric surfactant added in the invention is cocamidopropyl betaine containing long carbon chains and polar groups, so that the surface energy of the system can be effectively reduced, the stability of organic components in a water system is improved, the irritation is low, the amphoteric surfactant is stable to acid and alkali and has excellent flexibility; and secondly, the cocoamidopropyl betaine and the witch hazel plant extract are compounded for use, and the sterilization performance of the antibacterial hand sanitizer is improved to a certain extent by using the synergistic effect.
Solubilizer
The solubilizer of the invention refers to a surfactant with solubilizing ability. Solubilization refers to a process of increasing the solubility of a poorly soluble drug in a solvent and forming a solution under the action of a surfactant.
In a preferred embodiment, the solubilizing agent of the present invention is selected from one or more of glycerol, propylene glycol, polyethylene glycol, and polyglycerol.
In a preferred embodiment, the solubilizing agent of the present invention is glycerol.
Thickening agent
The thickening agent is also called a gelling agent and is a substance capable of increasing the viscosity of latex and liquid, and the thickening agent can improve the viscosity of a material system, so that the material system can keep a uniform and stable suspension state or an emulsion state or form gel; most thickeners combine an emulsifying action.
In a preferred embodiment, the thickener of the present invention is selected from one or more of hydroxypropyl methylcellulose, polyvinylpyrrolidone, and polyvinyl alcohol.
In a preferred embodiment, the thickener of the present invention is polyvinyl alcohol.
Antibacterial agent
In a preferred embodiment, the antibacterial agent of the present invention is selected from one or more of phenoxyethanol, salicylic acid, zinc pyrithione, cason, iodopropynyl butylcarbamate, sodium benzoate, and potassium sorbate.
In a preferred embodiment, the antimicrobial agent of the present invention is potassium sorbate.
The antibacterial performance of the antibacterial hand sanitizer can be effectively improved by adding the antibacterial agent, and the possible reason is that the antibacterial hand sanitizer is easily combined with sulfydryl of a microbial enzyme system to destroy a plurality of enzyme systems due to the synergistic effect of the potassium sorbate and other components in the system; the potassium sorbate can effectively inhibit the activity of mould, aerobic bacteria and yeast, and also can prevent the reproduction of microorganisms such as staphylococcus, clostridium botulinum and salmonella.
In a second aspect, the invention provides a method for preparing an antibacterial hand sanitizer, which at least comprises the following steps:
1) adding water to the reactor;
2) adding a water softener and an organic base into a reactor, uniformly stirring, and heating to 40-50 ℃;
3) adding fatty acid into the reactor, stirring for 0.5-2 hours, and cooling to below 30 ℃ after the fatty acid is completely dissolved;
4) adding a surfactant into the reactor, and stirring for 10-30 minutes;
5) adding a solubilizer into the reactor, and stirring for 10-30 minutes;
6) adding a thickening agent into the reactor, and stirring for 10-30 minutes;
7) adding an antibacterial agent into the reactor, and stirring for 10-30 minutes;
8) adding skin care natural plant extract into the reactor, and stirring for 10-30 minutes;
9) stirring for 2 hours until the reaction materials are completely dissolved to be uniform; and (5) obtaining the product.
It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.
In addition, the raw materials used are commercially available from national chemical reagents, unless otherwise specified.
Examples
Example 1
The antibacterial hand sanitizer is prepared from 1.3 parts by weight of natural plant extract, 0.3 part by weight of water softener, 2.4 parts by weight of organic base, 8 parts by weight of organic acid, 2.8 parts by weight of surfactant, 2 parts by weight of solubilizer, 0.3 part by weight of thickener, 0.8 part by weight of antibacterial agent and 80 parts by weight of water.
The natural plant extract is a witch hazel extract.
The extraction method of the witch hazel extract comprises the following steps: pulverizing Hamamelis mollis extract, adding isopropanol, extracting at 70 deg.C under reflux, filtering, adding hexane into the filtrate, separating, collecting the lower layer, and evaporating the solvent with rotary evaporator.
The volume ratio of the isopropanol to the hexane is 1: 0.3.
the water softener is sodium tripolyphosphate.
The organic base is triethanolamine.
The fatty acid is coconut oil fatty acid.
The surfactant is cocamidopropyl betaine.
The solubilizer is glycerol.
The thickening agent is polyvinyl alcohol.
The antibacterial agent is potassium sorbate.
The preparation method of the antibacterial hand sanitizer comprises the following steps:
1) adding water to the reactor;
2) adding a water softener and an organic base into a reactor, uniformly stirring, and heating to 45 ℃;
3) adding fatty acid into the reactor, stirring for 1 hour, and cooling to below 30 ℃ after the fatty acid is completely dissolved;
4) adding a surfactant into the reactor, and stirring for 25 minutes;
5) adding a solubilizer into the reactor, and stirring for 25 minutes;
6) adding a thickening agent into the reactor, and stirring for 25 minutes;
7) adding an antibacterial agent into the reactor, and stirring for 25 minutes;
8) adding skin care natural plant extract into the reactor, and stirring for 25 minutes;
9) stirring for 2 hours until the reaction materials are completely dissolved to be uniform; and (5) obtaining the product.
Example 2
The antibacterial hand sanitizer comprises, by weight, 0.1 part of a natural plant extract, 0.05 part of a water softener, 1 part of an organic base, 5 parts of an organic acid, 1 part of a surfactant, 1 part of a solubilizer, 0.1 part of a thickener, 0.1 part of an antibacterial agent and 70 parts of water.
The natural plant extract is a witch hazel extract.
The extraction method of the witch hazel extract comprises the following steps: pulverizing Hamamelis mollis extract, adding isopropanol, extracting at 70 deg.C under reflux, filtering, adding hexane into the filtrate, separating, collecting the lower layer, and evaporating the solvent with rotary evaporator.
The volume ratio of the isopropanol to the hexane is 1: 0.3.
the water softener is sodium tripolyphosphate.
The organic base is triethanolamine.
The fatty acid is coconut oil fatty acid.
The surfactant is cocamidopropyl betaine.
The solubilizer is glycerol.
The thickening agent is polyvinyl alcohol.
The antibacterial agent is potassium sorbate.
The preparation method of the antibacterial hand sanitizer comprises the following steps:
1) adding water to the reactor;
2) adding a water softener and an organic base into a reactor, uniformly stirring, and heating to 45 ℃;
3) adding fatty acid into the reactor, stirring for 1 hour, and cooling to below 30 ℃ after the fatty acid is completely dissolved;
4) adding a surfactant into the reactor, and stirring for 25 minutes;
5) adding a solubilizer into the reactor, and stirring for 25 minutes;
6) adding a thickening agent into the reactor, and stirring for 25 minutes;
7) adding an antibacterial agent into the reactor, and stirring for 25 minutes;
8) adding skin care natural plant extract into the reactor, and stirring for 25 minutes;
9) stirring for 2 hours until the reaction materials are completely dissolved to be uniform; and (5) obtaining the product.
Example 3
The antibacterial hand sanitizer is prepared from, by weight, 2 parts of a natural plant extract, 0.5 part of a water softener, 5 parts of an organic base, 10 parts of an organic acid, 5 parts of a surfactant, 5 parts of a solubilizer, 0.5 part of a thickener, 2 parts of an antibacterial agent and 90 parts of water.
The natural plant extract is a witch hazel extract.
The extraction method of the witch hazel extract comprises the following steps: pulverizing Hamamelis mollis extract, adding isopropanol, extracting at 70 deg.C under reflux, filtering, adding hexane into the filtrate, separating, collecting the lower layer, and evaporating the solvent with rotary evaporator.
The volume ratio of the isopropanol to the hexane is 1: 0.3.
the water softener is sodium tripolyphosphate.
The organic base is triethanolamine.
The fatty acid is coconut oil fatty acid.
The surfactant is cocamidopropyl betaine.
The solubilizer is glycerol.
The thickening agent is polyvinyl alcohol.
The antibacterial agent is potassium sorbate.
The preparation method of the antibacterial hand sanitizer comprises the following steps:
1) adding water to the reactor;
2) adding a water softener and an organic base into a reactor, uniformly stirring, and heating to 45 ℃;
3) adding fatty acid into the reactor, stirring for 1 hour, and cooling to below 30 ℃ after the fatty acid is completely dissolved;
4) adding a surfactant into the reactor, and stirring for 25 minutes;
5) adding a solubilizer into the reactor, and stirring for 25 minutes;
6) adding a thickening agent into the reactor, and stirring for 25 minutes;
7) adding an antibacterial agent into the reactor, and stirring for 25 minutes;
8) adding skin care natural plant extract into the reactor, and stirring for 25 minutes;
9) stirring for 2 hours until the reaction materials are completely dissolved to be uniform; and (5) obtaining the product.
Example 4
The antibacterial hand sanitizer is prepared from 1.3 parts by weight of natural plant extract, 0.3 part by weight of water softener, 2.4 parts by weight of organic base, 8 parts by weight of organic acid, 2.8 parts by weight of surfactant, 2 parts by weight of solubilizer, 0.3 part by weight of thickener, 0.8 part by weight of antibacterial agent and 80 parts by weight of water.
The natural plant extract is a witch hazel extract.
The extraction method of the witch hazel extract comprises the following steps: pulverizing Hamamelis mollis extract, adding isopropanol, extracting at 70 deg.C under reflux, filtering, adding hexane into the filtrate, separating, collecting the lower layer, and evaporating the solvent with rotary evaporator.
The volume ratio of the isopropanol to the hexane is 1: 1.
the water softener is sodium tripolyphosphate.
The organic base is triethanolamine.
The fatty acid is coconut oil fatty acid.
The surfactant is cocamidopropyl betaine.
The solubilizer is glycerol.
The thickening agent is polyvinyl alcohol.
The antibacterial agent is potassium sorbate.
The preparation method of the antibacterial hand sanitizer comprises the following steps:
1) adding water to the reactor;
2) adding a water softener and an organic base into a reactor, uniformly stirring, and heating to 45 ℃;
3) adding fatty acid into the reactor, stirring for 1 hour, and cooling to below 30 ℃ after the fatty acid is completely dissolved;
4) adding a surfactant into the reactor, and stirring for 25 minutes;
5) adding a solubilizer into the reactor, and stirring for 25 minutes;
6) adding a thickening agent into the reactor, and stirring for 25 minutes;
7) adding an antibacterial agent into the reactor, and stirring for 25 minutes;
8) adding skin care natural plant extract into the reactor, and stirring for 25 minutes;
9) stirring for 2 hours until the reaction materials are completely dissolved to be uniform; and (5) obtaining the product.
Example 5
The antibacterial hand sanitizer is prepared from 1.3 parts by weight of natural plant extract, 0.3 part by weight of water softener, 2.4 parts by weight of organic base, 8 parts by weight of organic acid, 2.8 parts by weight of surfactant, 2 parts by weight of solubilizer, 0.3 part by weight of thickener, 0.8 part by weight of antibacterial agent and 80 parts by weight of water.
The natural plant extract is a witch hazel extract.
The extraction method of the witch hazel extract comprises the following steps: pulverizing Hamamelis mollis extract, adding isopropanol, extracting at 70 deg.C under reflux, filtering, adding hexane into the filtrate, separating, collecting the lower layer, and evaporating the solvent with rotary evaporator.
The volume ratio of the isopropanol to the hexane is 1: 0.05.
the water softener is sodium tripolyphosphate.
The organic base is triethanolamine.
The fatty acid is coconut oil fatty acid.
The surfactant is cocamidopropyl betaine.
The solubilizer is glycerol.
The thickening agent is polyvinyl alcohol.
The antibacterial agent is potassium sorbate.
The preparation method of the antibacterial hand sanitizer comprises the following steps:
1) adding water to the reactor;
2) adding a water softener and an organic base into a reactor, uniformly stirring, and heating to 45 ℃;
3) adding fatty acid into the reactor, stirring for 1 hour, and cooling to below 30 ℃ after the fatty acid is completely dissolved;
4) adding a surfactant into the reactor, and stirring for 25 minutes;
5) adding a solubilizer into the reactor, and stirring for 25 minutes;
6) adding a thickening agent into the reactor, and stirring for 25 minutes;
7) adding an antibacterial agent into the reactor, and stirring for 25 minutes;
8) adding skin care natural plant extract into the reactor, and stirring for 25 minutes;
9) stirring for 2 hours until the reaction materials are completely dissolved to be uniform; and (5) obtaining the product.
Example 6
The antibacterial hand sanitizer is prepared from 1.3 parts by weight of natural plant extract, 0.3 part by weight of water softener, 2.4 parts by weight of organic base, 8 parts by weight of organic acid, 2.8 parts by weight of surfactant, 2 parts by weight of solubilizer, 0.3 part by weight of thickener, 0.8 part by weight of antibacterial agent and 80 parts by weight of water.
The natural plant extract is a witch hazel extract.
The extraction method of the witch hazel extract comprises the following steps: pulverizing Hamamelis mollis extract, adding isopropanol, extracting at 70 deg.C under reflux, filtering, adding hexane into the filtrate, separating, collecting the lower layer, and evaporating the solvent with rotary evaporator.
The volume ratio of the isopropanol to the hexane is 1: 0.3.
the water softener is sodium tripolyphosphate.
The organic base is triethanolamine.
The fatty acid is coconut oil fatty acid.
The surfactant is fatty alcohol-polyoxyethylene ether.
The solubilizer is glycerol.
The thickening agent is polyvinyl alcohol.
The antibacterial agent is potassium sorbate.
The preparation method of the antibacterial hand sanitizer comprises the following steps:
1) adding water to the reactor;
2) adding a water softener and an organic base into a reactor, uniformly stirring, and heating to 45 ℃;
3) adding fatty acid into the reactor, stirring for 1 hour, and cooling to below 30 ℃ after the fatty acid is completely dissolved;
4) adding a surfactant into the reactor, and stirring for 25 minutes;
5) adding a solubilizer into the reactor, and stirring for 25 minutes;
6) adding a thickening agent into the reactor, and stirring for 25 minutes;
7) adding an antibacterial agent into the reactor, and stirring for 25 minutes;
8) adding skin care natural plant extract into the reactor, and stirring for 25 minutes;
9) stirring for 2 hours until the reaction materials are completely dissolved to be uniform; and (5) obtaining the product.
Evaluation of Performance
1. Skin irritation:
the antibacterial hand sanitizer prepared in the examples 1-6 is respectively smeared on the backs of the hands of 6 persons, the hand sanitizer is smeared once in the morning and at night and is continuously used for a week, and the conditions, erythema and inflammation are recorded; the results are shown in Table 1 below.
2. Stability:
the antibacterial hand sanitizer prepared in examples 1 to 6 were respectively sealed and placed at a temperature of 20 ℃ for 15 days, the humidity was maintained at 75% or more, and after 15 days, whether the antibacterial hand sanitizer is settled or turbid or not was observed and recorded, and the results are shown in table 1 below.
TABLE 1 test results
| Irritation property | Stability of | |
| Example 1 | Is free of | Good stability |
| Example 2 | Is free of | Good stability |
| Example 3 | Is free of | Good stability |
| Example 4 | Erythema | With a small amount of delamination |
| Example 5 | Erythema | With a small amount of delamination |
| Example 6 | Is free of | A large number of layers |
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.
Claims (10)
1. The antibacterial hand sanitizer is characterized by comprising the following preparation raw materials in parts by weight: 0.1-2 parts of natural plant extract, 0.05-0.5 part of water softener, 1-5 parts of organic base, 5-10 parts of organic acid, 1-5 parts of surfactant, 1-5 parts of solubilizer, 0.1-0.5 part of thickener, 0.1-2 parts of antibacterial agent and 70-90 parts of water.
2. The antibacterial hand sanitizer according to claim 1, wherein the natural plant extract is one or more selected from the group consisting of seaweed extract, witch hazel extract, aloe vera, chamomile extract, green tea extract, licorice extract, and rhodiola extract.
3. The antibacterial hand sanitizer according to claim 2, wherein the extraction method of the witch hazel extract at least comprises the following steps: pulverizing Hamamelis mollis extract, adding isopropanol, extracting at 65-75 deg.C under reflux, filtering, adding hexane into the filtrate, separating, collecting the lower layer, and evaporating the solvent with rotary evaporator.
4. The antibacterial hand sanitizer according to claim 3, wherein the volume ratio of isopropanol to hexane is 1: (0.1-0.8).
5. The antibacterial hand sanitizer according to claim 1, wherein the water softening agent is one or more selected from the group consisting of EDTA-4 sodium, sodium tripolyphosphate, sodium metaphosphate, and trisodium phosphate.
6. The antibacterial hand sanitizer according to claim 1, wherein the organic base is one or more selected from monoethanolamine, triethanolamine, and diethanolamine.
7. The antibacterial hand sanitizer according to claim 1, wherein the fatty acids are selected from one or more of coconut oil fatty acid, palm oil fatty acid, soybean oil fatty acid, rapeseed oil fatty acid, and peanut oil fatty acid.
8. The antimicrobial hand sanitizer according to claim 1, wherein the surfactant is selected from one or more of cocamidopropyl betaine, amine oxides, alkyl glycosides, fatty alcohol polyoxyethylene ethers.
9. The antibacterial hand sanitizer according to claim 1, wherein the solubilizer is selected from one or more of glycerol, propylene glycol, polyethylene glycol and polyglycerol.
10. A method of preparing an antibacterial hand sanitizer according to any one of claims 1 to 9, comprising at least the steps of:
1) adding water to the reactor;
2) adding a water softener and an organic base into a reactor, uniformly stirring, and heating to 40-50 ℃;
3) adding fatty acid into the reactor, stirring for 0.5-2 hours, and cooling to below 30 ℃ after the fatty acid is completely dissolved;
4) adding a surfactant into the reactor, and stirring for 10-30 minutes;
5) adding a solubilizer into the reactor, and stirring for 10-30 minutes;
6) adding a thickening agent into the reactor, and stirring for 10-30 minutes;
7) adding an antibacterial agent into the reactor, and stirring for 10-30 minutes;
8) adding skin care natural plant extract into the reactor, and stirring for 10-30 minutes;
9) stirring for 2 hours until the reaction materials are completely dissolved to be uniform; and (5) obtaining the product.
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| CN202110272935.5A CN112773739A (en) | 2021-03-13 | 2021-03-13 | Antibacterial hand sanitizer and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113476359A (en) * | 2021-06-22 | 2021-10-08 | 广东菁萃生物科技有限公司 | Antibacterial foam hand sanitizer and preparation method thereof |
| FR3124080A1 (en) * | 2021-06-21 | 2022-12-23 | Evergreen Land Limited | Antimicrobial topical formulation |
-
2021
- 2021-03-13 CN CN202110272935.5A patent/CN112773739A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3124080A1 (en) * | 2021-06-21 | 2022-12-23 | Evergreen Land Limited | Antimicrobial topical formulation |
| CN113476359A (en) * | 2021-06-22 | 2021-10-08 | 广东菁萃生物科技有限公司 | Antibacterial foam hand sanitizer and preparation method thereof |
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