CN112741844A - Preparation method of soft-shelled turtle capsule - Google Patents
Preparation method of soft-shelled turtle capsule Download PDFInfo
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- CN112741844A CN112741844A CN202011586866.7A CN202011586866A CN112741844A CN 112741844 A CN112741844 A CN 112741844A CN 202011586866 A CN202011586866 A CN 202011586866A CN 112741844 A CN112741844 A CN 112741844A
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- 241001482311 Trionychidae Species 0.000 title claims abstract description 22
- 239000002775 capsule Substances 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000000843 powder Substances 0.000 claims abstract description 39
- 108010010803 Gelatin Proteins 0.000 claims abstract description 29
- 229920000159 gelatin Polymers 0.000 claims abstract description 29
- 239000008273 gelatin Substances 0.000 claims abstract description 29
- 235000019322 gelatine Nutrition 0.000 claims abstract description 29
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 29
- 239000007901 soft capsule Substances 0.000 claims abstract description 27
- 238000002844 melting Methods 0.000 claims abstract description 17
- 230000008018 melting Effects 0.000 claims abstract description 17
- 239000007788 liquid Substances 0.000 claims abstract description 16
- 238000001035 drying Methods 0.000 claims abstract description 15
- 238000004140 cleaning Methods 0.000 claims abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 14
- 238000003825 pressing Methods 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 43
- 239000003292 glue Substances 0.000 claims description 25
- 241000270666 Testudines Species 0.000 claims description 22
- 239000000243 solution Substances 0.000 claims description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- 238000010438 heat treatment Methods 0.000 claims description 13
- 230000001954 sterilising effect Effects 0.000 claims description 13
- 238000004659 sterilization and disinfection Methods 0.000 claims description 13
- 238000004108 freeze drying Methods 0.000 claims description 10
- 239000011259 mixed solution Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 9
- 239000008213 purified water Substances 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- 238000004321 preservation Methods 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 5
- 238000000576 coating method Methods 0.000 claims description 5
- 239000000498 cooling water Substances 0.000 claims description 5
- 238000007710 freezing Methods 0.000 claims description 5
- 230000008014 freezing Effects 0.000 claims description 4
- 238000001704 evaporation Methods 0.000 claims description 3
- 230000008020 evaporation Effects 0.000 claims description 3
- 239000000049 pigment Substances 0.000 claims description 3
- 238000000748 compression moulding Methods 0.000 claims description 2
- 238000009413 insulation Methods 0.000 claims description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 12
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 238000003860 storage Methods 0.000 description 3
- 241000338116 Amyda Species 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000008176 lyophilized powder Substances 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 241001194850 Pelodiscus Species 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 238000004506 ultrasonic cleaning Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/586—Turtles; Tortoises, e.g. terrapins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Meat, Egg Or Seafood Products (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a preparation method of a soft-shelled turtle capsule, which comprises the steps of preparing gelatin liquid coat of the soft-shelled turtle capsule through gelatin melting operation, preparing medicinal powder by processing soft-shelled turtles, pressing the medicinal powder into the prepared gelatin liquid coat through a pressing and forming step, and finally cleaning and drying to prepare a soft capsule product. The soft capsule prepared from soft-shelled turtles by the method can enable people to conveniently and quickly absorb the medicinal powder, thereby achieving the purpose of quick treatment.
Description
Technical Field
The invention relates to a preparation method of a soft-shelled turtle capsule.
Background
The Chinese softshell turtle, commonly called soft-shelled turtle and soft-shelled turtle, is a folk traditional nourishing nutritional food, and has the functions of nourishing yin, clearing heat, softening hardness and dissipating stagnation. The turtle has obvious improvement on symptoms of patients with tumor and hepatitis after taking the turtle, is beneficial to enhancing the curative effect of the main drug, and has good treatment effect on patients with liver-kidney yin deficiency caused by deficiency or deficiency. The soft-shelled turtles at the present stage are generally used for food nourishing, have slow absorption speed of the potency of drugs and are inconvenient for people to use.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides a preparation method of a soft-shelled turtle capsule which can be conveniently used.
The invention is realized by adopting the following technical scheme: a method for preparing soft-shelled turtle capsules comprises the steps of preparing a coating for coating soft-shelled turtle medicinal powder gelatin solution through a gelatin solution preparation step, preparing medicinal powder from soft-shelled turtles through cooling treatment, pressing the medicinal powder into the prepared gelatin solution coating through a pressing forming step, and finally cleaning and drying to prepare soft capsule products, wherein the specific preparation steps are as follows:
(1) the preparation method of the gelatin solution comprises the following steps:
adding purified water into a water bath type glue melting tank, and heating the glue melting tank in a water bath manner;
closing an exhaust valve and an upper cover of the water bath type glue melting tank, adding glycerol and gelatin into the water bath type glue melting tank, starting a vacuum stirrer, and uniformly stirring the mixed solution;
thirdly, heating the mixed liquid, opening a cooling water valve of the buffer tank, and opening a vacuum pump to defoam the glue solution in the water bath type glue melting tank;
adding pigment into the mixed solution, and stirring the mixed solution until the mixed solution is uniform after continuous stirring;
taking out the mixed liquid in the water bath type glue dissolving tank, and preserving heat by using an insulation box;
(2) preparing the turtle into medicinal powder, namely quickly freezing the turtle, then performing primary crushing and primary and freeze drying to prepare coarse powder of the turtle, then performing secondary crushing and secondary freeze drying to prepare fine powder, and performing microwave sterilization on the fine powder to finally prepare turtle sterilization powder;
(3) and (3) capsule compression molding: pouring the turtle sterilization powder into a hopper of a soft capsule machine by using a material spoon, connecting the heat preservation box filled with the gelatin solution to the soft capsule machine, starting equipment, and adjusting the pressure of a rotary mold to prepare soft capsules;
(4) capsule pressure cleaning and drying: cleaning the prepared soft capsule with an ultrasonic soft capsule cleaning machine, and heating and drying the soft capsule in an evaporation mode.
Preferably, the purified water is heated in a water bath at a temperature of 55 ℃ to 60 ℃.
Preferably, the mass ratio of the purified water, the gelatin and the glycerol is 12: 10:5.
Preferably, the mixed solution is heated to 65 ℃, and then a cooling water valve of a buffer tank is opened for defoaming.
Preferably, the temperature of the incubator is 50 ℃ to 55 ℃.
Preferably, the microwave sterilization of the fine powder is performed at a microwave frequency of 2450 + -50 MHz (megahertz) and a power of 10KW, and the sterilization time is not less than 30 seconds.
Compared with the prior art, the invention prepares the gelatin solution coat of the turtle capsule by gelatin melting operation, prepares the medicinal powder by processing soft-shelled turtle, presses the medicinal powder into the prepared gelatin solution coat by a pressing and forming step, and finally prepares the soft capsule product by cleaning and drying. The soft capsule prepared from soft-shelled turtles by the method can enable people to conveniently and quickly absorb the medicinal powder, thereby achieving the purpose of quick treatment.
Detailed Description
The present invention is further described below, and it should be noted that, in the case of no conflict, any combination between the embodiments or technical features described below may form a new embodiment.
Firstly, preparing gelatin solution:
using matched equipment: a water bath type glue melting tank (comprising a vacuum pump, a cold and hot water circulating pump, a water boiling pot and a buffer tank) and a vacuum stirrer.
1) Adding water into the water boiler until the volume of the water boiler is 4/5, opening a circulating water pump and a steam valve, directly contacting steam with circulating water and heating the circulating water, and heating the temperature of the circulating water to 95-100 ℃.
2) Taking 12 parts of purified water, adding the purified water into a water bath type glue dissolving tank, simultaneously starting a circulating water pump, sending hot circulating water in a water boiling pot to a water bath type glue dissolving tank interlayer, and adding hot purified water into the water bath type glue dissolving tank to 55-60 ℃.
3) Closing the exhaust valve and the upper cover, starting the vacuum stirrer and the vacuum pump, sucking 10 parts of gelatin and 5 parts of glycerol into the water bath type gelatin melting tank by using the vacuum tube of the vacuum pump, closing the valve of the vacuum pump after adding the gelatin, and stirring uniformly after the gelatin is fully expanded.
4) And then heating the mixed liquid in the glue melting tank to 65-70 ℃, opening a cooling water valve of the buffer tank, and opening a vacuum pump to defoam the mixed liquid in the water bath type glue melting tank.
5) After the defoaming time was 30-60 minutes (the bubbles were almost removed visually), the vacuum pump was turned off and the exhaust valve was opened. The pigment was added to the gelatin and after stirring for a further 15 minutes, the stirring was switched off.
6) Binding a water bath type glue melting pouring outlet by using a 60-mesh double-layer nylon filter bag, placing a glue solution heat-preserving barrel below the glue outlet, opening a liquid outlet valve, placing the stirred glue solution in the glue solution heat-preserving barrel, and preserving the temperature at 50-55 ℃.
Secondly, the step of preparing the soft-shelled turtle into medicinal powder:
1) quick-freezing: opening the cold storage (Q003) to ensure that the temperature in the cold storage is between 18 ℃ below zero and 20 ℃ below zero, stacking the turtle which is completely cultured and weighed in a turnover box, and quickly freezing for more than 10 hours in the cold storage.
2) Primary crushing and primary freeze drying: and (3) connecting a liquid nitrogen pipeline interface in the Dewar flask with an interface of the crusher, and checking that the interface of the liquid nitrogen is tight.
The first-stage crushing and drying is to crush the quick-frozen soft-shelled turtle into coarse soft-shelled turtle powder at the ultra-low temperature of-35 to-160 ℃ on a coarse crusher (Q004). And then keeping the coarse powder in a freeze dryer (Q001 or Q002) at-33 to-35 ℃ for 1 hour, then turning into a frozen state for freezing, starting a condenser, vacuumizing the material when a condensing cylinder is cooled to be lower than-45 ℃, starting heating the carrier to dry the material when the vacuum degree of a freeze drying box reaches-0.1 MPa, and simultaneously observing and recording the temperature and the drying time in the material.
Heating the freeze dryer carrier to enable the temperature in the material to gradually reach 33-35 ℃ from-33 ℃ to-35 ℃ (the shelf temperature is 40 ℃), adjusting the material within 8 hours 12-13 times in the heating process, and continuing to maintain vacuum and keep warm and dry for 24 hours when the temperature in the material reaches 35 ℃ at the maximum and the recording instrument grid curve is based on one line to obtain the first-grade freeze-dried powder.
The above step notes:
a) the pressure of liquid nitrogen is not lower than 0.2MPa, the temperature in the crushing cavity of the crusher is-35 to-50 ℃, and the temperature in the crusher is-150 to-160 ℃. The grain diameter after primary crushing is less than or equal to 5 microns.
b) Experiments prove that the moisture content can not be changed too much if the freeze drying is carried out for more than 32 hours at the temperature of between 33 ℃ below zero and 35 ℃ below zero, and can generally reach the requirement of about 5 percent, and the moisture content is more than or equal to 9.2 percent if the drying time is about 16 hours.
3) Secondary crushing and secondary freeze drying: cleaning the site of the second-stage crushing room and the freeze drying room, and replacing the state marks. The operating rules of the inspection post and the batch production records of the post are complete.
And (3) connecting a liquid nitrogen pipeline interface in the Dewar flask with an interface of the crusher, and checking that the interface of the liquid nitrogen is tight.
The second-stage pulverizing and drying is to pulverize the first-stage freeze-dried coarse powder of Amyda sinensis into fine powder at-35 deg.C to-160 deg.C in a fine pulverizer (Q005) to obtain the fine powder of whole Amyda sinensis. And performing secondary freeze drying for 8 hr in a freeze dryer (Q001 or Q002) at 33-35 deg.C (shelf temperature of 40 deg.C), vacuum degree of-0.1 MPa, and condenser temperature of-45 deg.C to obtain secondary lyophilized powder.
The above step notes:
a) the pressure of liquid nitrogen is not lower than 0.2MPa, the temperature in the crushing cavity of the crusher is-35 to-50 ℃, and the temperature in the crusher is-150 to-160 ℃.
b) The total yield from the living bodies of the turtles to the second-level freeze-dried powder is 33.0-35.0%.
c) The second-level lyophilized powder can be pulverized to 80 mesh, and the water content should not exceed 7.0%.
4) Microwave sterilization: the microwave sterilization of the fine powder is carried out at a microwave frequency of 2450 +/-50 MHz (megahertz) and a power of 10KW, and the sterilization time is not less than 30 seconds. .
And (3) performing microwave sterilization on the second-level freeze-dried powder by using a microwave drying sterilizer (Q006) to prepare the whole soft-shelled turtle sterilization powder.
Thirdly, the capsule is pressed and formed: the preparation equipment uses a soft capsule machine.
1) Pouring the medicinal powder (sterilized powder) into a hopper of a soft capsule machine by using a material spoon.
2) And opening the heat preservation box, and properly discharging the gelatin solution to ensure that the gelatin solution can normally flow out.
3) Connecting the discharge port of the heat preservation box with a main case of the soft capsule machine, and paying attention to wrapping the rubber tube with a heat preservation adhesive tape, wherein the temperature of gelatin liquid flowing into the rubber tube is required to be ensured to be 50-60 ℃.
4) Starting the equipment, adjusting the pressure of the rotary die, paying attention to the fact that the die is damaged due to overlarge pressure of the rotary die, and preparing the soft capsule.
Fourthly, capsule pressure cleaning and drying: cleaning the prepared soft capsules by using an ultrasonic soft capsule cleaning machine, sequentially performing the steps of soaking, spraying and ultrasonic cleaning, and drying the cleaned soft capsules in an evaporation mode.
Finally, the qualified product is subjected to external packing, and the soft capsules are prepared from the soft-shelled turtles by the method, so that the soft capsules can be directly used and absorbed by people.
The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.
Claims (6)
1. A preparation method of soft-shelled turtle capsules is characterized by comprising the following steps: preparing a gelatin solution coating wrapping turtle medicinal powder by a gelatin solution preparation step, preparing medicinal powder from turtles through cold treatment, pressing the medicinal powder into the prepared gelatin solution coating through a pressing and forming step, and finally preparing a soft capsule product through cleaning and drying, wherein the preparation steps are as follows:
(1) the preparation method of the gelatin solution comprises the following steps:
adding purified water into a water bath type glue melting tank, and heating the glue melting tank in a water bath manner;
closing an exhaust valve and an upper cover of the water bath type glue melting tank, adding glycerol and gelatin into the water bath type glue melting tank, starting a vacuum stirrer, and uniformly stirring the mixed solution;
thirdly, heating the mixed liquid, opening a cooling water valve of the buffer tank, and opening a vacuum pump to defoam the glue solution in the water bath type glue melting tank;
adding pigment into the mixed solution, and stirring the mixed solution until the mixed solution is uniform after continuous stirring;
taking out the mixed liquid in the water bath type glue dissolving tank, and preserving heat by using an insulation box;
(2) preparing the turtle into medicinal powder, namely quickly freezing the turtle, then performing primary crushing and primary and freeze drying to prepare coarse powder of the turtle, then performing secondary crushing and secondary freeze drying to prepare fine powder, and performing microwave sterilization on the fine powder to finally prepare turtle sterilization powder;
(3) and (3) capsule compression molding: pouring the turtle sterilization powder into a hopper of a soft capsule machine by using a material spoon, connecting the heat preservation box filled with the gelatin solution to the soft capsule machine, starting equipment, and adjusting the pressure of a rotary mold to prepare soft capsules;
(4) capsule pressure cleaning and drying: cleaning the prepared soft capsule with an ultrasonic soft capsule cleaning machine, and heating and drying the soft capsule in an evaporation mode.
2. The method for preparing turtle capsule according to claim 1, wherein the method comprises the following steps: when heated in a water bath, the purified water is heated at a temperature of 55 ℃ to 60 ℃.
3. The method for preparing turtle capsule according to claim 1, wherein the method comprises the following steps: the mass ratio of the purified water to the gelatin to the glycerol is 12: 10:5.
4. The method for preparing turtle capsule according to claim 1, wherein the method comprises the following steps: and heating the mixed solution to 65 ℃, and then opening a cooling water valve of the buffer tank to defoam.
5. The method for preparing turtle capsule according to claim 1, wherein the method comprises the following steps: the temperature of the heat preservation box is 50-55 ℃.
6. The method for preparing turtle capsule according to claim 1, wherein the method comprises the following steps: the fine powder is sterilized by microwave at 2450 + -50 MHz (megahertz) and 10KW power for at least 30 s.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011586866.7A CN112741844A (en) | 2020-12-29 | 2020-12-29 | Preparation method of soft-shelled turtle capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011586866.7A CN112741844A (en) | 2020-12-29 | 2020-12-29 | Preparation method of soft-shelled turtle capsule |
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| CN112741844A true CN112741844A (en) | 2021-05-04 |
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| CN202011586866.7A Pending CN112741844A (en) | 2020-12-29 | 2020-12-29 | Preparation method of soft-shelled turtle capsule |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100858107B1 (en) * | 2008-03-12 | 2008-09-10 | 박상수 | A method of soft-shelled turtle power capsule through hyper-low temperature frozen drying method |
| CN104147049A (en) * | 2014-07-17 | 2014-11-19 | 扬州诺瑞药业有限公司 | Preparation method of turtle capsule |
| WO2018045547A1 (en) * | 2016-09-09 | 2018-03-15 | 石家庄以岭药业股份有限公司 | Applications of jujube seed oil in treating medicinal insomnia |
| CN108498480A (en) * | 2018-06-01 | 2018-09-07 | 江苏康缘阳光药业有限公司 | Prevented in Chinese medicinal soft capsule sol-process gelatin congeal power reduction process |
| CN109692127A (en) * | 2019-03-15 | 2019-04-30 | 王征 | A kind of preparation method sealing Caplet |
| CN110522737A (en) * | 2019-08-28 | 2019-12-03 | 扬州诺瑞药业有限公司 | The preparation process of chlorampheicol capsules BP |
-
2020
- 2020-12-29 CN CN202011586866.7A patent/CN112741844A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100858107B1 (en) * | 2008-03-12 | 2008-09-10 | 박상수 | A method of soft-shelled turtle power capsule through hyper-low temperature frozen drying method |
| CN104147049A (en) * | 2014-07-17 | 2014-11-19 | 扬州诺瑞药业有限公司 | Preparation method of turtle capsule |
| WO2018045547A1 (en) * | 2016-09-09 | 2018-03-15 | 石家庄以岭药业股份有限公司 | Applications of jujube seed oil in treating medicinal insomnia |
| CN108498480A (en) * | 2018-06-01 | 2018-09-07 | 江苏康缘阳光药业有限公司 | Prevented in Chinese medicinal soft capsule sol-process gelatin congeal power reduction process |
| CN109692127A (en) * | 2019-03-15 | 2019-04-30 | 王征 | A kind of preparation method sealing Caplet |
| CN110522737A (en) * | 2019-08-28 | 2019-12-03 | 扬州诺瑞药业有限公司 | The preparation process of chlorampheicol capsules BP |
Non-Patent Citations (2)
| Title |
|---|
| 何宁, 中国科学技术大学出版社 * |
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Application publication date: 20210504 |