CN105267264B

CN105267264B - Whole Chinese angelica capsule preparation process and whole Chinese angelica capsule

Info

Publication number: CN105267264B
Application number: CN201510479196.1A
Authority: CN
Inventors: 丁永峰; 马维鹏
Original assignee: Gansu Longmai Medicinal Materials Co Ltd
Current assignee: Gansu Longmai Medicinal Materials Co Ltd
Priority date: 2015-08-03
Filing date: 2015-08-03
Publication date: 2020-03-31
Anticipated expiration: 2035-08-03
Also published as: CN105267264A

Abstract

The invention discloses a whole angelica capsule preparation process and a whole angelica capsule. The preparation process of the whole angelica sinensis capsule mainly comprises the following steps: cleaning, cutting into pieces, vacuum freeze-drying, coarse crushing, superfine crushing, total mixing, microwave sterilizing, and encapsulating. The preparation process disclosed by the invention reduces the loss of the effective components of the angelica in the processing process to the maximum extent, and avoids sulfur pollution and ash pollution caused by the traditional processing method; the whole Chinese angelica capsule prepared by the preparation process disclosed by the invention has the advantages of convenience for carrying, high biological absorptivity, accurate administration dosage, homology of medicine and food and the like, and can increase nutrition, improve physique and be beneficial to health after being frequently eaten.

Description

Whole Chinese angelica capsule preparation process and whole Chinese angelica capsule

Technical Field

The invention belongs to the field of medicinal preparations, and particularly relates to a preparation process of a whole angelica capsule and the whole angelica capsule.

Background

The Chinese angelica has the following effects as an important Chinese medicinal material: (1) effects on uterus: research shows that the angelica has direct inhibition effect on the isolated uterus of animals such as rabbits, guinea pigs, mice, rats, dogs and the like which are not pregnant, are pregnant early, are pregnant late and are postpartum, so that the rhythmic contraction gradually disappears and is in a flaccid state. And inhibiting uterine contraction caused by hypophysin, histamine, epinephrine and acetylcholine. (2) Effect on the cardiovascular system: the angelica decoction or the volatile oil contained in the roots and leaves can obviously inhibit the myocardial contraction frequency, prolong the refractory period of isolated atria of rabbits, and have therapeutic effect on the atrial fibrillation of anesthetized cats and dogs caused by acetylcholine or current. (3) Effects on the blood system: after the water decoction of the angelica sinensis is orally taken by rats, the blood coagulation time of blood plasma is prolonged, the thrombus can be reduced, the thrombus growth speed is slowed down, and the anti-thrombus effect is obvious. (4) Action on digestive system: the traditional Chinese medicine composition has a protective effect on liver poisoning caused by acute carbon tetraoxide of mice; has effects of relieving fibrosis and promoting hepatocyte function recovery to chronic hepatic injury. The angelica sinensis extract has a good curative effect on emphysema complicated by chronic bronchitis and pulmonary heart disease in early or remission stage, and can remarkably improve the lung ventilation function and recover physical strength after being used. (5) Has the following immune function: the angelica and the sodium ferulate and the angelica polysaccharide which are extracted from the angelica have obvious stimulation effect on a mononuclear-macrophage system and have immune regulation and recovery effect on organisms with low immune function. Angelica sinensis can also promote lymphocyte transformation of healthy people. (6) Anti-inflammatory action: the radix Angelicae sinensis contains n-butenolide and benzene lactone, and can relax airway smooth muscle and relieve bronchial asthma caused by histamine-acetylcholine. (7) The anticancer effect is as follows: dang Gui can be widely used in various tumors, especially in gynecological tumors, especially in cases of stagnation of qi and blood and accumulation of blood stasis. For middle and late stage cancer with blood deficiency and emaciation or patients with vital qi deficiency after operation, radiotherapy and chemotherapy, radix Angelicae sinensis can be selected to strengthen body resistance and resist cancer. (8) The antibacterial effect is as follows: the radix Angelicae sinensis decoction has slight inhibitory effect on Escherichia coli, typhoid and paratyphoid bacillus, dysentery bacillus, proteus bacillus, diphtheria bacillus, etc. in test tube. (9) Removing free radical: the angelica sinensis has the functions of resisting lipid peroxidation, directly eliminating free radicals, inhibiting oxidation reaction and free radical reaction, and can be combined with biological membrane phospholipid to protect membrane lipid from resisting damage of free radicals to tissues. (10) Aging resistance and aging resistance: the angelica decoction has obvious influence on the learning and memory of mice, and the angelica can improve the dementia caused by aluminum trioxide, reduce the lipid peroxidation level of the brain of a dementia mouse and the activity of B-type monoamine oxidation and treat the senile dementia by using the Y-maze method. (11) Promoting hematopoiesis: the ferulic acid and the polysaccharide in the angelica water extract can remarkably promote the generation of hemoglobin and erythrocyte, so the angelica water extract has the function of anti-anemia. (12) The medicine is also used in surgery, and has good curative effects on stasis dissipating and swelling diminishing in the swelling and sore period, and blood nourishing and tissue regeneration promoting in the ulcer period. (13) Chinese angelica has the function of protecting liver: and the control of the total number of microorganisms or bacteria is an important content of the quality control of the traditional Chinese medicinal materials and the preparations thereof.

Angelica and angelica preparations are rich in nutrients, which easily deteriorate during storage. Researches find that the cause of deterioration of angelica and angelica preparations is related to the moisture content of angelica, and the higher the moisture content is, the higher the possibility of mildew of angelica is; secondly, the temperature is another condition for angelica deterioration, the microorganism propagation is difficult at low temperature, and the high temperature can accelerate the propagation speed of the microorganism and the mildew. Under the high-temperature and high-humidity environment, the fluidity of the cell contents of the angelica sinensis is enhanced, the cell walls are easy to flow out, and the cell walls gradually overflow to the surface of the medicinal materials, so that the medicinal materials are blackened and even caked, and the color and luster of the medicinal materials are influenced. Therefore, how to retain the nutritional components of angelica to the maximum extent possible and how to reduce the deterioration of angelica preparations during storage is a problem that the angelica processing enterprises must solve. In order to retain the nutritional ingredients of angelica to the maximum extent, the existing angelica processing enterprises generally extract the effective ingredients such as angelica oil from angelica in a high-temperature heating way, however, the medicinal ingredients in angelica cannot be fully utilized by adopting the way. In order to avoid the angelica from mildewing, being damaged by worms and the like in the storage period, the traditional angelica processing is usually fumigated by sulfur, and sulfur dioxide generated by the combustion of the sulfur has the function of killing microorganisms and insects, thereby preventing insects and mildew. However, sulfur dioxide meets the moisture in the angelica, sulfurous acid is formed and remains in the angelica, and the sulfur dioxide residue in the angelica exceeds the standard, thereby causing harm to human bodies. In addition, the existing angelica preparation is generally angelica root block, angelica powder or angelica extract, has low bioavailability and inconvenient carrying, and is not easy to control the edible dosage of the angelica.

Therefore, there is an urgent need for a Chinese angelica preparation and a processing technology thereof, which fully retain the medicinal components in the Chinese angelica, have no sulfur pollution, high bioavailability and convenient carrying and can effectively control the edible dosage.

Disclosure of Invention

The invention aims to provide a preparation process of a whole angelica sinensis capsule, which can effectively retain medicinal components in angelica sinensis, control the total number of microorganisms and bacteria in an angelica sinensis preparation, prevent the angelica sinensis preparation from deteriorating and effectively avoid sulfur pollution in the traditional process. The invention also provides a whole angelica sinensis capsule which has high bioavailability and convenient carrying and can effectively control the edible dosage of angelica sinensis.

In order to achieve the purpose, the invention adopts the following technical scheme:

a preparation process of a whole angelica capsule comprises the following steps: collecting fresh radix Angelicae sinensis, cleaning, cutting into pieces, vacuum lyophilizing, coarse pulverizing, micronizing, mixing, microwave sterilizing, and encapsulating.

As a further improved technical scheme of the invention, the collection, cleaning and slicing of the fresh angelica sinensis in the origin adopt a conventional process, the slicing step is completed in a slicing machine, and the thickness of the sliced angelica sinensis slice is less than or equal to 1 cm.

As a further improved technical scheme of the invention, the vacuum freeze-drying comprises prefreezing and freeze-drying, wherein the prefreezing step is to put the sliced angelica slices into a freeze-drying machine to be frozen to-30 to-40 ℃, and the temperature is kept for 3 to 5 hours, so that the angelica slices in the freeze-drying machine all reach the eutectic point of-30 to-40 ℃; and the step of freeze drying is that after the heat preservation is finished, the temperature in a freeze dryer is reduced to minus 45 ℃ to minus 50 ℃, the vacuum pumping and the sublimation drying are started, the vacuum degree is kept at 5 Pa to 10Pa, the negative pressure is kept for 6 hours to 10 hours, then the pressure is slowly increased to the normal pressure, the freeze dryer is started, and the freeze-dried angelica slices are taken out. Preferably, the pre-freezing step is to put the sliced angelica slices into a freeze dryer to be frozen to-35 ℃, and keep the temperature for 3 hours, so that the angelica slices in the freeze dryer reach the eutectic point of-35 ℃; and the step of freeze drying is that the temperature in a freeze dryer is reduced to-50 ℃ after the heat preservation is finished, the vacuum pumping and the sublimation drying are started, the vacuum degree is kept at 10Pa, the negative pressure is kept for 6h, then the pressure is slowly increased to the normal pressure, the freeze dryer is started, and the freeze-dried angelica slices are taken out.

As a further improved technical scheme of the invention, the coarse crushing is carried out in a traditional Chinese medicine grinding mill, the rotating speed of the traditional Chinese medicine grinding mill is controlled to be less than or equal to 3000r/min, and the particle size of the crushed angelica powder is 50-80 meshes; the superfine grinding is carried out in a traditional Chinese medicine superfine grinder, the rotating speed of the traditional Chinese medicine superfine grinder is controlled to be 3500-4000 r/min, and the particle size of the ground angelica powder is 200-300 meshes. Preferably, the rotation speed of the traditional Chinese medicine grinding mill is controlled at 2500r/min, and the particle size of the ground angelica powder is 50 meshes; the rotation speed of the traditional Chinese medicine ultrafine grinder is controlled at 4000r/min, and the particle size of the ground angelica powder is 300 meshes.

According to the technical scheme, the microwave sterilization step is to lay the totally mixed angelica powder in a microwave sterilizer, wherein the laying thickness of the angelica powder is 5-10 cm; the sterilization time is 8-12 min, the sterilization power is 10-20 KW, and the microwave frequency band for sterilization is 900-3000 MHz. Preferably, the laying thickness of the angelica powder is 8cm, the sterilization time is 10min, the sterilization power is 20KW, and the microwave frequency band for sterilization is 2450 MHz.

As a further improved technical scheme of the invention, the capsule filling step is completed in a capsule filling machine, capsule shells adopted by the capsule filling machine are plant capsule shells, and the weight of the angelica powder filled in each capsule shell is 0.3-1 g. Preferably, each capsule shell is filled with angelica powder with a weight of 0.5 g.

In order to realize another purpose of the invention, the invention adopts the technical scheme that:

a whole Chinese angelica capsule is prepared by adopting the preparation process of the whole Chinese angelica capsule.

Advantageous effects

The invention directly collects the fresh angelica in the origin to be cleaned and cut into pieces, and controls the thickness of the angelica piece to be less than 1cm, which is beneficial to accelerating the drying speed of the angelica; the drying of the angelica slices can be rapidly realized and the effective components of the angelica are greatly reserved by adopting a vacuum freeze-drying technology; the two-stage crushing process of coarse crushing and superfine crushing is adopted, so that the crushing efficiency can be effectively improved, the particle size of the angelica powder is reduced, and the bioavailability of the angelica is effectively improved; by adopting a microwave sterilization technology, the Chinese angelica powder can be sterilized quickly, the sulfur pollution of the traditional process is effectively avoided, and the deterioration of the whole Chinese angelica capsule is prevented; the capsule filling technology is adopted, so that the angelica powder is convenient to carry and eat, the edible dosage of each time can be effectively controlled, and the deterioration and loss of effective components in the angelica can be further prevented.

Detailed Description

Collecting fresh radix Angelicae sinensis, cleaning, cutting in a slicer, and cutting into radix Angelicae sinensis pieces with thickness less than 1 cm. Then putting the angelica slices into a freeze dryer for freeze drying. The freeze drying step is mainly divided into two steps, wherein the first step is pre-freezing, so that the effective components in the angelica can be quickly locked, and the effective components in the angelica slices are prevented from being oxidized; and the second step is freeze drying, the temperature in a freeze dryer is further reduced after pre-freezing, vacuumizing and sublimation drying are carried out, the pressure is slowly increased to normal pressure after drying, the freeze dryer is started, and the freeze-dried angelica slices are taken out. The conditions and effects of the freeze-drying step are shown in table 1.

TABLE 1 selection of conditions for lyophilization and drying effectiveness thereof

As can be seen from table 1, the freeze-drying step is preferably: the pre-freezing step is to place the sliced angelica slices into a freeze dryer for pre-freezing to-35 ℃, and preserving heat for 3 hours to ensure that the angelica slices in the freeze dryer reach the eutectic point of-35 ℃; and the step of freeze drying is that the temperature in a freeze dryer is reduced to-50 ℃ after the heat preservation is finished, the vacuum pumping and the sublimation drying are started, the vacuum degree is kept at 10Pa, the negative pressure is kept for 8 hours, then the pressure is slowly increased to the normal pressure, the freeze dryer is started, and the freeze-dried angelica slices are taken out.

After vacuum freeze-drying, placing the angelica slices into a traditional Chinese medicine grinding mill for coarse crushing, controlling the rotating speed of the traditional Chinese medicine grinding mill to be less than or equal to 3000r/min, and controlling the particle size of the crushed angelica powder to be 50-80 meshes; and then placing the coarsely crushed angelica powder into a traditional Chinese medicine ultrafine pulverizer for ultrafine crushing, controlling the rotating speed of the traditional Chinese medicine ultrafine crusher at 3500-4000 r/min, and controlling the particle size of the crushed angelica powder to be 200-300 meshes. In order to improve the bioavailability of the angelica and ensure the production efficiency of the angelica capsule, the rotating speed of the traditional Chinese medicine grinding mill is controlled at 2500r/min, and the particle size of the crushed angelica powder is 50 meshes; the rotation speed of the traditional Chinese medicine ultrafine grinder is controlled at 4000r/min, and the particle size of the ground angelica powder is 300 meshes. After being crushed, the angelica powder is mixed totally, so that the distribution of the angelica powder is more uniform.

After the total mixing, the angelica powder is laid in a microwave sterilizer and is sterilized by a microwave sterilization method so as to kill microorganisms and bacteria in angelica, prevent the angelica capsule from going bad and prolong the shelf life of the angelica capsule. The conditions and effects of the microwave sterilization step are shown in table 2.

TABLE 2 selection of conditions for microwave sterilization and the effectiveness of the sterilization

As can be seen from Table 2, the microwave sterilization step can further dry the Angelica sinensis powder, in addition to having a sterilizing effect. The optimal conditions for microwave sterilization of the angelica powder are as follows: the laying thickness of the angelica powder is 8cm, the sterilization time is 10min, the sterilization power is 20KW, and the microwave frequency band for sterilization is 2450 MHz.

In order to make the sterilized angelica powder convenient to carry, store and eat, the angelica powder is sterilized and then is subjected to capsule filling treatment. The capsule filling is completed in a capsule filling machine, capsule shells adopted by the capsule filling machine are plant capsule shells, and the weight of the Chinese angelica powder filled in each capsule shell is 0.3-1 g. Generally, the dosage of angelica is usually controlled to be about 0.5-1 g per time, so that the weight of the angelica powder filled in each capsule shell is preferably 0.5g, and when the required amount of angelica is 1g, two full angelica capsules can be taken.

The invention is scientifically refined by fusing the modern biotechnology with the whole angelica, does not mix any other substances, is produced strictly according to pharmaceutical specifications, has advanced process and high biological absorptivity. The inventive capsule can be taken together with other foods and medicines without contraindication, has homology of medicine and food, can increase nutrition, improve physique and is beneficial to health. Appropriate changes and modifications to the embodiments described above will become apparent to those skilled in the art from the disclosure and teachings of the foregoing description. Therefore, the present invention is not limited to the specific embodiments disclosed and described above, and some modifications and variations of the present invention should fall within the scope of the claims of the present invention. Furthermore, although specific terms are employed herein, they are used in a generic and descriptive sense only and not for purposes of limitation.

Claims

1. A preparation process of a whole angelica capsule comprises the following steps: collecting fresh whole radix Angelicae sinensis of original origin, cleaning, cutting into pieces, vacuum freeze-drying, coarse pulverizing, micronizing, mixing, microwave sterilizing, and encapsulating; the method comprises the following steps of collecting fresh angelica at the origin, cleaning and slicing by adopting a conventional process, wherein the slicing step is finished in a slicing machine, and the thickness of sliced angelica slices is less than or equal to 1 cm; the vacuum freeze-drying comprises prefreezing and freeze-drying, wherein the prefreezing step is to put the sliced angelica slices into a freeze-drying machine to be frozen to-30 to-40 ℃, and the temperature is kept for 3 to 5 hours, so that the angelica slices in the freeze-drying machine reach the eutectic point of-30 to-40 ℃; after the heat preservation is finished, the temperature in a freeze dryer is reduced to minus 45 ℃ to minus 50 ℃, the vacuum pumping and the sublimation drying are started, the vacuum degree is kept at 5-10 Pa, the negative pressure is kept for 6-10h, then the pressure is slowly increased to normal pressure, the freeze dryer is started, and the freeze-dried angelica slices are taken out; the coarse crushing is carried out in a traditional Chinese medicine grinding mill, the rotating speed of the traditional Chinese medicine grinding mill is controlled to be less than or equal to 3000r/min, and the particle size of the crushed angelica powder is 50-80 meshes; the superfine grinding is carried out in a traditional Chinese medicine superfine grinder, the rotating speed of the traditional Chinese medicine superfine grinder is controlled to be 3500-4000 r/min, and the particle size of the ground angelica powder is 200-300 meshes; the microwave sterilization step is to lay the totally mixed angelica powder in a microwave sterilizer, wherein the laying thickness of the angelica powder is 5-10 cm; the sterilization time is 8-12 min, the sterilization power is 10-20 KW, and the microwave frequency band for sterilization is 900-3000 MHz.

2. The process for preparing the whole angelica sinensis capsule according to claim 1, wherein the process comprises the following steps: the pre-freezing step is that the Chinese angelica slices after being cut into blocks are put into a freeze dryer to be frozen to-35 ℃, and the temperature is kept for 3 hours, so that the Chinese angelica slices in the freeze dryer all reach the eutectic point of-35 ℃; and the step of freeze drying is that the temperature in a freeze dryer is reduced to-50 ℃ after the heat preservation is finished, the vacuum pumping and the sublimation drying are started, the vacuum degree is kept at 10Pa, the negative pressure is kept for 6h, then the pressure is slowly increased to the normal pressure, the freeze dryer is started, and the freeze-dried angelica slices are taken out.

3. The process for preparing the whole angelica sinensis capsule according to claim 1, wherein the process comprises the following steps: the rotation speed of the traditional Chinese medicine grinding mill is controlled at 2500r/min, and the particle size of the crushed Chinese angelica powder is 50 meshes; the rotation speed of the traditional Chinese medicine ultrafine grinder is controlled at 4000r/min, and the particle size of the ground angelica powder is 300 meshes.

4. The process for preparing the whole angelica sinensis capsule according to claim 1, wherein the process comprises the following steps: the laying thickness of the angelica powder is 8cm, the sterilization time is 10min, the sterilization power is 20KW, and the microwave frequency band for sterilization is 2450 MHz.

5. The process for preparing the whole angelica sinensis capsule according to claim 1, wherein the process comprises the following steps: the capsule filling step is completed in a capsule filling machine, capsule shells adopted by the capsule filling machine are plant capsule shells, and the weight of the angelica powder filled in each capsule shell is 0.3-1 g.