CN112740044A - 神经病症的诊断或预后方法 - Google Patents

神经病症的诊断或预后方法 Download PDF

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CN112740044A
CN112740044A CN201980044315.7A CN201980044315A CN112740044A CN 112740044 A CN112740044 A CN 112740044A CN 201980044315 A CN201980044315 A CN 201980044315A CN 112740044 A CN112740044 A CN 112740044A
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S·杜格斯
W·杜迪
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Abstract

本发明涉及一种对受试者的神经病症进行诊断或预后的方法。所述方法包括确定来自所述受试者的生物样品中一种或多种生物标志物的定量或定性水平；以及基于所述生物样品中所述或每种生物标志物的所述定量或定性水平对所述受试者的所述神经病症进行诊断或预后。

Description

神经病症的诊断或预后方法
技术领域
本发明涉及一种对受试者的神经病症进行诊断或预后的方法。所述方法包括确定来自受试者的生物样品中一种或多种生物标志物的定量或定性水平；以及基于生物样品中所述或每种生物标志物的定量或定性水平对受试者的神经病症进行诊断或预后。
背景技术
肌萎缩性侧索硬化(ALS)，也称为运动神经元病(MND)，是由上下运动神经元的进行性变性和死亡、蛋白质聚集、严重肌萎缩和呼吸功能不全造成的致死性运动神经元病症。中位生存期为从症状发作开始的2年与5年之间。ALS表现为家族性ALS(FALS；～10％的病例)或散发性ALS(SALS；～90％的病例)。估计ALS的发病率介于0.3与2.6例/100,000之间(在欧洲为2.16/100,000人年，在爱尔兰为2.0/100,000人年)。
在动物模型和ALS患者中的研究表明，运动神经元变性开始于神经肌肉接点处并且突触后肌肉变化可发挥积极作用。研究已表明，骨骼肌具有功能分泌活性。肌肉分泌蛋白质组(secretome)包含外泌体-进行功能蛋白、mRNA和miRNA的细胞间运输的囊泡。外泌体可以自分泌/旁分泌的方式在肌细胞或其他类型的细胞上起作用并且有助于肌肉生长和再生、全身新陈代谢和其他功能。
错误折叠蛋白，诸如SOD1、TDP-43或FUS蛋白在受影响的神经元以及邻近神经胶质中的病理性聚集可以视为ALS的标志。若干近期研究已表明，这些细胞内蛋白可以通过囊泡介导的胞吐作用释放，并且接着被邻近细胞吞噬，从而允许以自身延续性(self-perpetuating)方式传递至相邻的运动神经元。此外，在家族性ALS中，已经鉴定出参与自噬途径和多囊泡生物发生的基因(诸如ALSIN、VAPB、CHMP2B和VCP)的突变。总而言之，这些数据强烈表明散发性和家族性ALS患者的核内体和溶酶体途径的破坏-这两条途径均参与外泌体发生。
诊断很慢，通常需要患者历经数月的时间看若干专家：从症状发作到确诊的平均时间是13-18个月。因此，问题/需要是更快速地诊断ALS。
发明内容
根据本发明的第一方面，提供一种对受试者的神经病症进行诊断或预后的方法，所述方法包括以下步骤：
(a)确定来自受试者的生物样品中一种或多种生物标志物的定量或定性水平；以及
(b)基于生物样品中所述或每种生物标志物的定量或定性水平对受试者的神经病症进行诊断或预后；
其中所述或每种生物标志物选自：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；C0L5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；EEF1D；TPI1；SSBP1；PSMB8；PSAP；PSMB7；CAPZA1；PRDX1；PGDN；MMP1；NUCB2；HMGB1；AHNAK；FNDC1；DENR；PENK；S100A11；RPL29；RPL27；RPL8；SRSF2；SF3B4；SBSN；LYAR；NUDC；CRLF1；TGFB1；CAT；CTSD；DLD；EPB41L2；PSMB9；RPS14；RPL7A；COLEC12；SMARCC2；TAGLN2；CCT4；ASPH；GPS1；CDK13；SH3GL2；HBA1；APEX1；PSMB5；TXN；AXL；RPS8；SET；RPS18；CFL1；DMKN；RPL22；RPL6；FKBP10；PAFAH1B1；S100A13；PSMA6；SERPINE1；CAPRIN1；SEPT7；VTN；ENPP2；NEO1；DKC1；CHI3L1；SK0R1；SSRP1；COL4A2；NME1；CFB；EIF2S3；DPYSL2；NUMA1；KTN1；CHID1；EFEMP1；YWHAZ；LDHB；SDCBP；TLN1；DES；APP；以及DAG1。
优选地，所述或每种生物标志物选自：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；C0L5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；以及CAPRIN1。
更优选地，所述或每种生物标志物选自：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；C0L5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；CAPRIN1；DES；APP；以及DAG1。
更优选地，所述或每种生物标志物选自：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；DES；APP；以及DAG1。
任选地，确定步骤(a)包括确定来自受试者的生物样品中的两种或更多种生物标志物的定量或定性水平。
更任选地，确定步骤(a)包括确定来自受试者的生物样品中的三种、四种、五种、八种、十种、二十种、二十五种、二十八种、三十种、四十种、五十种、六十种、七十种、八十种、九十种、一百种或更多种生物标志物的定量或定性水平。
任选地，确定步骤(a)包括确定来自受试者的生物样品中的所有生物标志物的定量或定性水平。
任选地或另外，确定步骤(a)包括确定来自受试者的生物样品中的每种生物标志物的定量或定性水平。
任选地，所述或每种生物标志物是基因。更任选地，所述或每种生物标志物是核酸。更任选地，所述或每种生物标志物是脱氧核糖核酸。
任选地，所述或每种生物标志物是基因的翻译产物。
任选地，所述或每种生物标志物是选自以下的基因的翻译产物：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；C0L5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；EEF1D；TPI1；SSBP1；PSMB8；PSAP；PSMB7；CAPZA1；PRDX1；PGDN；MMP1；NUCB2；HMGB1；AHNAK；FNDC1；DENR；PENK；S100A11；RPL29；RPL27；RPL8；SRSF2；SF3B4；SBSN；LYAR；NUDC；CRLF1；TGFB1；CAT；CTSD；DLD；EPB41L2；PSMB9；RPS14；RPL7A；COLEC12；SMARCC2；TAGLN2；CCT4；ASPH；GPS1；CDK13；SH3GL2；HBA1；APEX1；PSMB5；TXN；AXL；RPS8；SET；RPS18；CFL1；DMKN；RPL22；RPL6；FKBP10；PAFAH1B1；S100A13；PSMA6；SERPINE1；CAPRIN1；SEPT7；VTN；ENPP2；NEO1；DKC1；CHI3L1；SK0R1；SSRP1；COL4A2；NME1；CFB；EIF2S3；DPYSL2；NUMA1；KTN1；CHID1；EFEMP1；YWHAZ；LDHB；SDCBP；TLN1；DES；APP；以及DAG1。
优选地，所述或每种生物标志物是选自以下的基因的翻译产物：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；C0L5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；以及CAPRIN1。
更优选地，所述或每种生物标志物是选自以下的基因的翻译产物：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；C0L5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；CAPRIN1；DES；APP；以及DAG1。
更优选地，所述或每种生物标志物是选自以下的基因的翻译产物：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；DES；APP；以及DAG1。
任选地，所述或每种生物标志物是核糖核酸。
任选地，所述或每种生物标志物是具有选自以下的miRBase登录号的核糖核酸：MIMAT0000244；ENSG00000239126；MIMAT0016865；MIMAT0002813；MIMAT0004697；MIMAT0000245；MIMAT0000737；MIMAT0000088；MIMAT0000414；MIMAT0004955；MIMAT0000076；MIMAT0000067；MIMAT0018084；以及MIMAT0004813。
任选地，所述或每种生物标志物是具有选自SEQ ID No 109-122中的任何一个或多个的核酸序列的核糖核酸。
任选地，所述或每种生物标志物是蛋白质。更任选地，所述或每种生物标志物是肽。更任选地，所述或每种生物标志物是多肽。
任选地，所述或每种生物标志物是由选自以下的基因编码的蛋白质：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；COL5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；EEF1D；TPI1；SSBP1；PSMB8；PSAP；PSMB7；CAPZA1；PRDX1；PGDN；MMP1；NUCB2；HMGB1；AHNAK；FNDC1；DENR；PENK；S100A11；RPL29；RPL27；RPL8；SRSF2；SF3B4；SBSN；LYAR；NUDC；CRLF1；TGFB1；CAT；CTSD；DLD；EPB41L2；PSMB9；RPS14；RPL7A；COLEC12；SMARCC2；TAGLN2；CCT4；ASPH；GPS1；CDK13；SH3GL2；HBA1；APEX1；PSMB5；TXN；AXL；RPS8；SET；RPS18；CFL1；DMKN；RPL22；RPL6；FKBP10；PAFAH1B1；S100A13；PSMA6；SERPINE1；CAPRIN1；SEPT7；VTN；ENPP2；NEO1；DKC1；CHI3L1；SKOR1；SSRP1；COL4A2；NME1；CFB；EIF2S3；DPYSL2；NUMA1；KTN1；CHID1；EFEMP1；YWHAZ；LDHB；SDCBP；TLN1；DES；APP；以及DAG1。
优选地，所述或每种生物标志物是由选自以下的基因编码的蛋白质：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；COL5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；以及CAPRIN1。
更优选地，所述或每种生物标志物是由选自以下的基因编码的蛋白质：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；COL5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；CAPRIN1；DES；APP；以及DAG1。
更优选地，所述或每种生物标志物是由选自以下的基因编码的蛋白质：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；DES；APP；以及DAG1。
任选地，所述或每种生物标志物是具有选自以下的UniProtKB/Swiss-Prot登录号的蛋白质：P30101；Q76M96；P11142；P07093；Q15149；P11021；P19338；P09493；P24821；P17936；P20908；Q9Y240；P46821；Q13765；P25787；P46777；P60660；P07858；P10809；Q6NZI2；Q02818；P13667；P07237；043707；P29692；P60174；Q04837；P28062；P07602；Q99436；P52907；Q06830；Q7Z5L7；P03956；P80303；P09429；Q09666；Q4ZHG4；043583；P01210；P31949；P47914；P61353；P62917；Q01130；Q15427；Q6UWP8；Q9NX58；Q9Y266；075462；P01137；P04040；P07339；P09622；043491；P28065；P62263；P62424；Q5KU26；Q8TAQ2；P37802；P50991；Q12797；Q13098；Q14004；Q99962；P69905；P27695；P28074；P10599；P30530；P62241；Q01105；P62269；P23528；Q6E0U4；P35268；Q02878；Q96AY3；P43034；Q99584；P60900；P05121；Q14444；Q16181；P04004；Q13822；Q92859；060832；P36222；P84550；Q08945；P08572；P15531；P00751；P41091；Q16555；Q14980；Q86UP2；Q9BWS9；Q12805；P63104；P07195；000560；Q9Y490；P17661；P05067；以及Q14118。
优选地，所述或每种生物标志物是具有选自以下的UniProtKB/Swiss-Prot登录号的蛋白质：P30101；Q76M96；P11142；P07093；Q15149；P11021；P19338；P09493；P24821；P17936；P20908；Q9Y240；P46821；Q13765；P25787；P46777；P60660；P07858；P10809；Q6NZI2；Q02818；P13667；P07237；043707；以及Q14444。
更优选地，所述或每种生物标志物是具有选自以下的UniProtKB/Swiss-Prot登录号的蛋白质：P30101；Q76M96；P11142；P07093；Q15149；P11021；P19338；P09493；P24821；P17936；P20908；Q9Y240；P46821；Q13765；P25787；P46777；P60660；P07858；P10809；Q6NZI2；Q02818；P13667；P07237；043707；Q14444；P17661；P05067；以及Q14118。
更优选地，所述或每种生物标志物是具有选自以下的UniProtKB/Swiss-Prot登录号的蛋白质：P30101；Q76M96；P11142；P07093；Q15149；P17661；P05067；以及Q14118。
任选地，所述或每种生物标志物是具有选自SEQ ID No 1-108中的任何一个或多个的氨基酸序列的蛋白质。
任选地，神经病症是神经变性病症。
任选地，神经变性病症选自肌萎缩性侧索硬化(ALS；卢伽雷氏病(Lou Gehrig'sdisease)；运动神经元病；MND)、遗传性痉挛性截瘫(HSP)、原发性侧索硬化(PLS)、进行性肌萎缩(PMA)、进行性延髓麻痹(PBP)、假性延髓麻痹、脊髓延髓肌萎缩(SBMA)以及脊髓性肌萎缩。
任选地，诊断或预后步骤(b)包括将来自受试者的生物样品中的所述或每种生物标志物的定量或定性水平与正常样品中的所述或每种相应生物标志物的定量或定性水平相比较。
任选地，正常样品是来自未罹患神经病症，任选地神经变性病症，更任选地选自肌萎缩性侧索硬化(ALS；卢伽雷氏病；运动神经元病；MND)、遗传性痉挛性截瘫(HSP)、原发性侧索硬化(PLS)、进行性肌萎缩(PMA)、进行性延髓麻痹(PBP)、假性延髓麻痹、脊髓延髓肌萎缩(SBMA)以及脊髓性肌萎缩的神经变性病症的受试者的生物样品。
任选地，大于正常样品中的所述或每种相应生物标志物的定量或定性水平的来自受试者的生物样品中的所述或每种生物标志物的定量或定性水平指示神经病症，任选地神经变性病症，更任选地选自肌萎缩性侧索硬化(ALS；卢伽雷氏病；运动神经元病；MND)、遗传性痉挛性截瘫(HSP)、原发性侧索硬化(PLS)、进行性肌萎缩(PMA)、进行性延髓麻痹(PBP)、假性延髓麻痹、脊髓延髓肌萎缩(SBMA)以及脊髓性肌萎缩的神经变性病症的定量或定性水平。
任选地，来自受试者的生物样品中的所述或每种生物标志物的定量或定性水平大于正常样品中的所述或每种相应生物标志物的定量或定性水平指示神经病症，任选地神经变性病症，更任选地选自肌萎缩性侧索硬化(ALS；卢伽雷氏病；运动神经元病；MND)、遗传性痉挛性截瘫(HSP)、原发性侧索硬化(PLS)、进行性肌萎缩(PMA)、进行性延髓麻痹(PBP)、假性延髓麻痹、脊髓延髓肌萎缩(SBMA)以及脊髓性肌萎缩的神经变性病症的定量或定性存在。
任选地，确定步骤(a)包括确定来自受试者的生物样品中的一种或多种生物标志物的一个或多个子集的定量或定性水平。
任选地，确定步骤(a)包括确定来自受试者的生物样品中的一种或多种生物标志物的两个或更多个子集的定量或定性水平。
任选地，确定步骤(a)包括确定来自受试者的生物样品中的一种或多种生物标志物的三个、四个、五个、六个、七个、八个、九个、十个、十一个、十二个、十三个或十四个子集的定量或定性水平。
任选地，确定步骤(a)包括确定来自受试者的生物样品中的一种或多种生物标志物的第一、第二、第三、第四、第五、第六、第七、第八、第九、第十、第十一、第十二、第十三或第十四子集中的一个或多个的定量或定性水平。
任选地，第一子集包括选自以下的一种或多种生物标志物：PDIA3；和CCDC80。
任选地，第二子集包括HSPA8。
任选地，第三子集包括选自以下的一种或多种生物标志物：SERPINE2；和PLEC。
任选地，第四子集包括选自以下的一种或多种生物标志物：HSPA5；和NCL。
任选地，第五子集包括选自以下的一种或多种生物标志物：TPM1；和TNC。
任选地，第六子集包括IGFBP3。
任选地，第七子集包括选自以下的一种或多种生物标志物：COL5A1；CLEC11A；MAP1B；NACA；以及PSMA2。
任选地，第八子集包括选自以下的一种或多种生物标志物：RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；以及ACTN4。
任选地，第九子集包括选自以下的一种或多种生物标志物：EEF1D；TPI1；SSBP1；PSMB8；PSAP；PSMB7；CAPZA1；PRDX1；PGDN；MMP1；NUCB2；HMGB1；AHNAK；以及FNDC1。
任选地，第十子集包括选自以下的一种或多种生物标志物：DENR；PENK；S100A11；RPL29；RPL27；RPL8；SRSF2；SF3B4；SBSN；LYAR；NUDC；CRLF1；TGFB1；CAT；CTSD；DLD；EPB41L2；PSMB9；RPS14；RPL7A；COLEC12；SMARCC2；TAGLN2；CCT4；ASPH；GPS1；CDK13；SH3GL2；HBA1；APEX1；PSMB5；TXN；AXL；RPS8；SET；RPS18；CFL1；DMKN；RPL22；RPL6；FKBP10；PAFAH1B1；S100A13；PSMA6；SERPINE1；CAPRIN1；SEPT7；VTN；ENPP2；NEO1；DKC1；CHI3L1；SKOR1；SSRP1；COL4A2；NME1；CFB；EIF2S3；DPYSL2；NUMA1；KTN1；CHID1；EFEMP1；YWHAZ；LDHB；SDCBP；以及TLN1。
任选地，第十一子集包括选自以下的一种或多种生物标志物：DES；APP；以及DAG1。
任选地，第十二子集包括选自以下的一种或多种生物标志物：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；COL5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；以及CAPRIN1。
任选地，第十三子集包括选自以下的一种或多种生物标志物：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；COL5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；CAPRIN1；DES；APP；以及DAG1。
任选地，第十四子集包括选自以下的一种或多种生物标志物：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；DES；APP；以及DAG1。
任选地，确定步骤(a)包括确定第一、第二、第三、第四、第五、第六、第七、第八、第九、第十、第十一、第十二、第十三或第十四子集中的一个或多个中的所有生物标志物的定量或定性水平。
任选地，确定步骤(a)包括确定第一、第二、第三、第四、第五、第六、第七、第八、第九、第十、第十一、第十二、第十三或第十四子集中的一个或多个中的每种生物标志物的定量或定性水平。
任选地，诊断或预后步骤(b)包括将来自受试者的生物样品中的所述或每个子集中的所述或每种生物标志物的定量或定性水平与正常样品中的所述或每种相应生物标志物的定量或定性水平相比较。
任选地，正常样品是来自未罹患神经病症，任选地神经变性病症，更任选地选自肌萎缩性侧索硬化(ALS；卢伽雷氏病；运动神经元病；MND)、遗传性痉挛性截瘫(HSP)、原发性侧索硬化(PLS)、进行性肌萎缩(PMA)、进行性延髓麻痹(PBP)、假性延髓麻痹、脊髓延髓肌萎缩(SBMA)以及脊髓性肌萎缩的神经变性病症的受试者的生物样品。
任选地，大于正常样品中的所述或每种相应生物标志物的定量或定性水平的来自受试者的生物样品中的所述或每个子集中的所述或每种生物标志物的定量或定性水平指示神经病症，任选地神经变性病症，更任选地选自肌萎缩性侧索硬化(ALS；卢伽雷氏病；运动神经元病；MND)、遗传性痉挛性截瘫(HSP)、原发性侧索硬化(PLS)、进行性肌萎缩(PMA)、进行性延髓麻痹(PBP)、假性延髓麻痹、脊髓延髓肌萎缩(SBMA)以及脊髓性肌萎缩的神经变性病症的定量或定性水平。
任选地，来自受试者的生物样品中的所述或每个子集中的所述或每种生物标志物的定量或定性水平大于正常样品中的所述或每种相应生物标志物的定量或定性水平指示神经病症，任选地神经变性病症，更任选地选自肌萎缩性侧索硬化(ALS；卢伽雷氏病；运动神经元病；MND)、遗传性痉挛性截瘫(HSP)、原发性侧索硬化(PLS)、进行性肌萎缩(PMA)、进行性延髓麻痹(PBP)、假性延髓麻痹、脊髓延髓肌萎缩(SBMA)以及脊髓性肌萎缩的神经变性病症的定量或定性存在。
任选地或另外，确定步骤(a)还包括确定来自受试者的生物样品中的一种或多种生物标志物的定量或定性水平的另外步骤，其中所述或每种生物标志物是具有选自以下的miRBase登录号的核糖核酸：MIMAT0000244；ENSG00000239126；MIMAT0016865；MIMAT0002813；MIMAT0004697；MIMAT0000245；MIMAT0000737；MIMAT0000088；MIMAT0000414；MIMAT0004955；MIMAT0000076；MIMAT0000067；MIMAT0018084；以及MIMAT0004813。
任选地，生物样品选自全血、血清、血浆、尿液、间质液、腹膜液、宫颈拭子、泪液、唾液、颊面拭子、皮肤、脑组织和脑脊液。
更任选地，生物样品选自全血、血清和血浆。
更任选地，生物样品是全血。
PDIA3与Erp57是同义的(synonymous)。
附图说明
现将参考以下非限制性实施例和附图描述本发明的实施方案，在附图中：
图1是肌肉干细胞中的ALS标签(signature)的示意图；
图2(A)示出分化的肌肉干细胞的外泌体标志物的免疫染色，(B)肌细胞的外泌体分泌，以及(C)ALS肌细胞的多囊泡体包含比对照更多的外泌体；
图3示出用ALS或对照外泌体处理的健康肌管的代表性图像，其中ALS外泌体诱导细胞应激；
图4示出显示非编码RNA微阵列的表达值的箱形图(原始：左图；背景校正：中图；背景校正并归一化：右图)；
图5示出显示非编码RNA微阵列的RLE值的箱形图(平均值接近0通过质量控制)；
图6示出显示非编码RNA微阵列的NUSE值的箱形图(平均值<1.05通过质量控制)；
图7示出使用抗DAG抗体的情况下循环血清外泌体中的DAG1表达水平。值为平均值±SD。血清来自8名ALS患者(诊断后1个月)、11名健康受试者和9名帕金森患者。进行单因素方差分析，接着进行Tukey事后检验。**，与健康值显著不同，P<0.01；
图8示出循环血清外泌体中的HSPA8表达水平。值为平均值±SD。血清来自5名ALS患者(诊断后1个月)、9名健康受试者和7名帕金森患者。进行单因素方差分析，接着进行Tukey事后检验。*，**，与ALS值显著不同，分别为P<0.05和P<0.01；并且
图9示出针对总血清外泌体(CD63)的量归一化的从ALS患者的血清中分离的外泌体中每种生物标志物的水平，并且针对病理进展速率(△ALSFRS-R)绘图。
实施例
材料和方法
参与者和伦理批准
在运动神经元疾病中心(Motor Neuron Diseases center，PitiéSalpétrière)到场的18名ALS患者的三角肌上进行开放性活检。根据欧洲建议和法国立法从BTR(Bank ofTissues for Research，EU network EuroBioBank的参与者)获得来自年龄和性别匹配的健康受试者的二十一份三角肌活检物。该方案(NCT01984957)得到了当地伦理委员会的批准并且所有受试者根据惯例指南完成了知情同意书。
肌肉干细胞提取和培养
将肌肉活检物以机械方式解离并且涂板于如先前所述(Mamchaoui等,Skeletalmuscle,2011,PMID:22040608)的增殖培养基中，使用CD56磁珠分选系统(MACS,MiltenylBiotech)根据制造商的说明分选肌原细胞群。在分选细胞之前和之后使用抗结蛋白抗体通过免疫标记检查细胞培养物的肌原性，并且使细胞在杜氏改良的伊戈尔培养基(DMEM)中分化3天。最少80％的细胞群对于结蛋白是阳性的。
从培养基中提取外泌体
简而言之，使一千万肌肉干细胞(ALS和健康受试者，n＝3/组)在DMEM中分化3天。3天后，收获条件培养基，在室温(RT)下以300x g离心5分钟并且接着在4℃下以4000g离心20分钟，以除去任何死细胞和细胞碎片。通过0.22μm的过滤器过滤上清液以除去微粒。样品用于蛋白质和miRNA提取并储存于-80℃。
从外泌体中提取蛋白质
将一定体积的细胞培养基与来自细胞培养基的0.5体积的Total ExosomeIsolation Reagent
Figure BDA0002869599670000141
混合并且在4℃下孵育过夜。然后将样品在4℃下以10,000x g离心1h。将外泌体沉淀物重悬于25μl 8M Urea、50mM碳酸氢铵(pH 8.5)中，并且在4℃下用二硫苏糖醇(DTT)还原1h。然后使用Pierce BCA Protein Assay试剂盒
Figure BDA0002869599670000142
对蛋白质浓度定量。外泌体蛋白保持在-80℃。
通过质谱法确定蛋白质组特征谱(Proteome profile)
使用SmartDigest柱(Thermo)，根据制造商的说明将大约20μg的外泌体蛋白用胰蛋白酶在70℃和1400rpm下消化2小时。然后使用高pH反相自旋柱(Thermo)，根据制造商的说明将肽分级成8个级分。将分级的肽真空干燥，重悬并且在Q Exactive HF(Thermo)上通过数据依赖性质谱法分析，使用以下参数：正极性，m/z 400-2000MS分辨率70,000，AGC3e6，100ms IT，MS/MS分辨率17,500，AGC 5e5，50ms IT，隔离宽度3m/z，以及NCE 30，循环计数15。
数据库搜索和定量
使用ProteomeDiscoverer(Thermo)，针对Uniprot人数据库，针对半胰蛋白酶肽搜索所得的质谱文件以进行蛋白质鉴定并且基于<1％的错误发现率进行过滤。
蛋白质组特征谱分析
如果3个ALS平行测定的所观察到的丰度范围不与3个健康对照平行测定的范围重叠，那么选择蛋白质作为候选物。基于3个ALS平行测定的中值与健康平行测定的中值的差异对候选物排序。
从外泌体中提取miRNA
将一定体积的细胞培养基与来自细胞培养基的0.5体积的Total ExosomeIsolation Reagent
Figure BDA0002869599670000151
混合并且在4℃下孵育过夜。然后将样品在4℃下以10,000x g离心1h。将外泌体沉淀物用1ml的trizol重悬。添加0.2mL氯仿后，将样品在室温下孵育3分钟，然后在4℃下以12,000x g离心15分钟。然后将含水上层相与1/3体积的100％乙醇混合并彻底混合。接着将样品放置到来自InvitrogenTM(LifeTechnologiesTM)的总RNA和蛋白质分离试剂盒的收集管中的过滤器滤筒中。按照制造商的说明进行miRNA提取。使用Eukaryote Total RNA Nano 2.6(Agilent)和2100生物分析仪确定RNA质量。各自根据制造商的说明使用nanodrop确定RNA量。
miRNA特征谱和分析
按照制造商的说明(ThermoFisher Scientific,Waltham,MA)，使用FlashTagBiotin HSR RNA标记试剂盒对总RNA(150ng)进行poly(A)加尾和生物素标记并且杂交至Affymetrix GeneChip miRNA 4.0阵列，持续16小时(48℃)。然后将杂交混合液移除并且使用针对miRNA 4.0阵列的射流轨迹(fluidics script)，将阵列洗涤并在Fluidics Station450上染色。最后，在Affymetrix GCS3000 7G扫描仪上扫描阵列并且使用AffymetrixExpression Console软件(两者均来自ThermoFisher Scientific)估计初始质量控制数据。
miRNA组(miRNome)特征谱分析
使用R/Bioconductor软件包oligo和pd.mirna.4.0进行原始数据的进一步质量控制。这些软件包用于评估各样品的表达值分布、相对对数表达值(relative logexpression value，RLE)，以及归一化的非标准化标准误差(normalized unscaledstandard error，NUSE)，所有这些均与良好质量相一致。然后使用Affymetrix ExpressionConsole v 1.4.1.46，通过分位数归一化(quantile normalization)和高于背景检测(detection above background)对表达矩阵进行归一化。然后将差异表达的miRNA(ALS相对于健康)鉴定为绝对倍数变化>2且单因素未配对的方差分析p值<0.05的那些。
来自患者的血清样品
使用二氧化硅真空采血管收集血液样品，接着轻轻地翻转8-10分钟。在冰上孵育2h使其凝固之后，将样品在1,500g下离心15分钟。将100μl血清的等分试样转移至冷冻小瓶并且在-80℃下储存。募集年龄和性别匹配的八名ALS患者、11名健康受试者和9名帕金森患者(NCT01302600和NCT02305147)。
从血清中提取外泌体
通过添加6μl的Total Exosome Isolation Reagent、涡旋并在冰上孵育30分钟来使外泌体沉淀。然后将样品在室温下以10,000g离心10分钟。将沉淀物重悬于13.5μl的Urea4M/RIPA中并保持在冰上。与此同时，将6.3μl的Total Exosome Isolation Reagent添加至其余上清液、涡旋并在冰上孵育30分钟。然后将这些第二混合物在室温下以10,000g离心10分钟。将第二外泌体沉淀物重悬于13.5μl的Urea4M/RIPA中。然后将两份外泌体蛋白提取物混合在一起并用于斑点印迹(dot-blot)分析。将外泌体蛋白提取物储存于-80℃。
用于斑点印迹的样品制备
向5μl的外泌体蛋白提取物中添加1xNuPAGE(InvitrogenTM)。这些未还原的样品用于CD63分析。向其余22μl外泌体蛋白提取物中添加补充有1x还原试剂(InvitrogenTM)的1xNuPAGE(InvitrogenTM)。然后将所有样品在70℃下加热10分钟。
斑点印迹分析
将1μl还原或未还原的样品上样到甲醇预先活化的0.2μm PVDF
Figure BDA0002869599670000171
上。在室温下干燥5分钟后，将膜在甲醇中快速地重新活化并用Ponceau S
Figure BDA0002869599670000172
染色以控制上样。然后将膜在补充有5％牛奶的TBS-0.01％tween(TBS-T)中在4℃下封闭过夜。使用ZenonTM BiotinXX小鼠lgG1标记试剂盒，按照制造商的说明将针对CD63(TS63，InvitrogenTM)、β-肌营养不良蛋白聚糖(MANDAG2、7D11、DSHB)和HSPA8
Figure BDA0002869599670000173
的一抗与生物素临时偶联。简而言之，向1μg抗体中先添加5μl复合物，然后添加5μl封闭缓冲液。将抗CD63、抗β肌营养不良蛋白聚糖和抗HSPA8分别以1/1000、1/133和1/500稀释于TBS-T-5％牛奶中。
使用ZenonTM BiotinXX兔IgG标记试剂盒，按照制造商的说明，将针对Serpin E2(TS63，InvitrogenTM)、ERP57(PDIA3，
Figure BDA0002869599670000174
)、结蛋白(Y66，InvitrogenTM)、淀粉样蛋白前体蛋白(abeam)、CCDC80(InvitrogenTM)和网蛋白(invitrogenTM)的一抗与生物素临时偶联。简而言之，向1μg抗体中先添加5μl复合物，然后添加5μl封闭缓冲液。将抗Serpin E2、抗ERP57、抗结蛋白、抗淀粉样蛋白前体蛋白、抗CCDC80和抗网蛋白以1/1000稀释于TBS-T-5％牛奶中。
将膜与稀释的生物素偶联的一抗一起在室温下孵育45分钟。然后将膜在TBS-T中冲洗3次，持续5分钟。然后将膜与以1/250稀释于TBS-T-5％牛奶中的链霉抗生素蛋白-HRP(InvitrogenTM)一起在室温下孵育45分钟。然后将膜在TBS-T中冲洗3次，持续5分钟。使用SuperSignalTM West Pico PLUS Chemiluminescent Substrate(Thermo ScientificTM)对膜进行显现。使用UVP/ChemiDoc-
Figure BDA0002869599670000181
成像仪每15s获取图像，持续15分钟。然后使用FIJI软件分析图像。
统计分析
值为平均值±SD。进行单因素方差分析，接着进行Tukey事后检验，以评估ALS、健康受试者与帕金森受试者之间的生物标志物水平的差异。生物标志物水平与ALSFRS进展之间的关联使用皮尔森关联分析进行检验。显著性差异的截止值设置为P<0.05。
实施例1-肌肉干细胞中的ALS标签的鉴定
肌肉干细胞从患者和健康受试者(均为男性，30-67岁，n＝5/6每组)的肌肉活检物中提取，纯化(>80％肌原细胞)并且持续3天分化成肌管，其中使用GeneChip Human Exon1.0ST阵列(Affymetrix,Inc.,Cleveland,OH)分析样品；并且(A)示出在第二分量(y轴)上显示出ALS患者的明确分离的PCA图，ALS：蓝色，SBMA：粉色，SMA-III/IV：红色，对照：绿色；(B)示出在具有对ALS特异性最强的表达标签的30种基因中，根据CellWhere工具的分析，已经在外泌体相关亚细胞定位上观察到许多所述基因。
实施例2-ALS肌肉干细胞积聚并分泌比对照更多的外泌体
参考图2(A)，示出分化的肌肉干细胞的外泌体标志物的免疫染色。左图：来自ALS和SMA-III/IV患者，以及来自健康对照或失神经受试者的针对外泌体标志物(TSG101、CD63)作标记的培养的肌肉干细胞的代表性图像。右图：按肌核归一化的CD63荧光信号的定量。(n＝不同的ALS、SMA-III/IV、多神经炎和对照受试者的8、4、2、5份细胞培养物)。***，P<0,001。
图2(B)示出ALS肌细胞过度分泌外泌体。左图：来自培养基的外泌体沉淀物的代表性图片。从来自ALS和对照受试者的800,000个细胞的培养基中提取外泌体。在来自ALS患者和对照受试者的肌细胞的不同培养物上重复实验8次。右图：电子显微镜观察，其证实了外泌体(杯形囊泡)在沉淀物中的存在。外泌体在ALS沉淀物中更多。值得注意的是，在这些囊泡上进行的免疫染色证实，当它们对CD63和CD82为阳性时，它们是外泌体。
图2(C)示出ALS肌细胞的多囊泡体包含比对照更多的外泌体。左图：示出与对照相比，外泌体在ALS肌细胞的多囊泡体(MVB，以绿色和橙色突出显示)中的积聚的代表性电子显微镜观察图像。比例尺＝1μm。右图：MVB中的外泌体样囊泡数量的定量。双样本KS检验(Two sample Koimogorov-Smirnov test)证实了以下直观印象：与对照相比，ALS肌细胞的MVB包含更大数量的外泌体样囊泡(P<0.05)。
实施例3-来自ALS肌细胞的外泌体对健康肌管和运动神经元有毒性
参考图3(A)，其示出ALS外泌体诱导肌细胞萎缩。左图：用ALS或对照外泌体处理的健康肌管的代表性图像。用肌球蛋白重链对肌管染色(绿色)。右图：肌核域大小的定量(肌球蛋白重链染色的面积除以核的数量)。ALS外泌体处理的肌管具有较小的肌核域(*P<0.05；n＝6/组)。
图3(B)示出ALS外泌体诱导细胞应激。用ALS或对照外泌体处理的每个健康肌管随时间推移的小泡(bleb)数量的定量(n＝6/组)。双因素方差分析(有交互作用)，时间和处理，P<0.001。
图3(C)示出ALS外泌体诱导细胞死亡。左图：用ALS或对照外泌体处理的健康肌管的H2-Ax免疫染色的代表性免疫染色。中图：每个核的H2-Ax信号的定量。右图：培养物中的运动神经元核的损失的定量。
实施例4-作为ALS的生物标志物的特异性外泌体内含物的鉴定
外泌体内含物包括各种类型的生物分子，其中可能参与信号传导任务的那些包括蛋白质及其肽以及非编码RNA。肌肉干细胞(原代成肌细胞)获自ALS患者和健康对照的三角肌并且对其进行培养以形成分化的肌管。在培养3天后，使用total exosome isolationreagent(InvitrogenTM Life technologiesTM)从一千万个肌细胞的培养基中纯化外泌体。为了鉴定外泌体的内含物，我们进行纯化外泌体的蛋白质组和非编码RNA特征谱分析。
蛋白质生物标志物
蛋白质组质谱数据鉴定了105种蛋白质的肽(表1)，其水平相比于健康对照肌肉外泌体(n＝3)在ALS肌肉外泌体(n＝3)中一致增加。
由于蛋白质组样品针对蛋白质浓度归一化，还应注意，在ALS和健康肌肉外泌体两者中具有一致高水平的蛋白质也可以是良好的生物标志物，因为它们在每体积的ALS血液中仍可以是升高的，这是由于我们的以下观察：肌肉外泌体在ALS肌管中比在健康对照中以更大的丰度分泌。以此方式，鉴定了在ALS和健康肌肉外泌体中均具有一致高水平并且具有其他感兴趣的机械学特征的另外3个候选物。即，这些是DES、APP和DAG1。APP是阿尔茨海默病中的淀粉样斑块的主要组分。在所有肌肉组织类型中均观察到高水平的DES，但是在其他组织中完全不存在。DAG1是肌营养不良蛋白聚糖复合物的主要组分，其与多种肌营养不良有关。
表1.其肽通过质谱法鉴定为相比于健康对照在ALS肌细胞的外泌体中一致升高，或在ALS和健康肌肉外泌体中均具有一致高水平，并且具有病理学机械相关性的其他特征的108种蛋白质的列表。第一列给出Uniprot(http://www.uniprot.org/)所用的标准蛋白质ID，并且对应的基因名称在第2列给出。第3-5和6-8列分别示出ALS样品和健康对照样品中的肽水平。第9列指示ALS中的蛋白质肽的中值量与对照的差异，并且第10列基于第9列中的值对蛋白质排序。
Figure BDA0002869599670000211
Figure BDA0002869599670000221
Figure BDA0002869599670000231
表2.其肽通过质谱法鉴定为相比于健康对照在ALS肌细胞的外泌体中一致升高，或在ALS和健康肌肉外泌体中均具有一致高水平，并且具有病理学机械相关性的其他特征的25种蛋白质的列表。第一列给出Uniprot(http://www.uniprot.org/)所用的标准蛋白质ID，并且对应的基因名称在第2列给出。第3-5和6-8列分别示出ALS样品和健康对照样品中的肽水平。第9列指示ALS中的蛋白质肽的中值量与对照的差异。
Figure BDA0002869599670000241
非编码RNA生物标志物
非编码RNA物类的特征谱分析通过微阵列(使用Affymetrix
Figure BDA0002869599670000242
miRNA4.0阵列)在ALS外泌体(n＝5)上，相比于健康对照(n＝5)进行。在质量控制和归一化之后(参见图4-6)，单因素未配对的方差分析鉴定了相对于健康对照在ALS中显著失调的14种非编码RNA(表3：12种在ALS中上调，2种在ALS中下调)。在这些中，13种是微小RNA(通过其miRBase ID hsa-***和登录号MlMAT***指示)，并且1种是核仁小RNA snoU13(ENSG00000239126)。
表3.被鉴定为相比于健康对照，在ALS肌细胞的外泌体中显著失调的14种非编码RNA的列表。倍数变化和方差分析p值在最右列指出。
Figure BDA0002869599670000251
Figure BDA0002869599670000261
实施例6-针对不同疾病组的不同生物标志物的比较
从8名ALS患者、11名健康受试者和9名帕金森患者中收集血液样品。所选患者的患者特征在表4中给出。从血清中提取外泌体并且使用所述外泌体进行斑点印迹分析。从患有ALS疾病、帕金森病(疾病对照)的患者的血清，或从健康受试者中分离的外泌体中的DAG1水平在图7中给出，并且从患有ALS疾病、帕金森病(疾病对照)的患者的血清，或从健康受试者中分离的外泌体中的HSPA8水平在图8中给出。将针对总血清外泌体(CD63)的量归一化的从ALS患者的血清中分离的外泌体中每种生物标志物的水平针对病理进展速率(△ALSFRS-R)绘图并且在图9中给出。
表4.患者特征的列表。
Figure BDA0002869599670000262
Figure BDA0002869599670000271
本发明提供了一种强大的ALS基因表达标签以及ALS患者的肌细胞毒性和肌肉-运动神经元相互作用的新驱动物。通过研究来自散发性ALS患者的肌肉活检物的分化的肌(肌管)细胞，本发明示出：(1)从ALS患者分离的肌管的基因表达谱不仅与健康对照受试者完全分开聚类，而且与SBMA和SMA-III/IV疾病对照完全分开聚类(参见图1A)。最强有力地促成此ALS特异性标签的30种基因包括编码分泌或定位于外泌体中的蛋白质的基因(参见图1B)；(2)细胞内外泌体生物发生和细胞外外泌体分泌在ALS肌管中均急剧增加(参见图2A和B)，并且通过电子显微镜观察在ALS患者的肌肉活检物中观察到富集外泌体的多囊泡体(参见图2C)；(3)在肌肉失神经的人受试者(不是健康的，也不是SBMA或SMA-lll/IV)或肌肉失神经的健康鼠肌肉的肌管中未观察到增加的外泌体生物发生和分泌(参见图1、2A以及未示出的其他数据)，这表明外泌体分泌不单纯是疾病的下游后果。
序列表
<110> 阿尔斯特大学(UNIVERSITY OF ULSTER)
<120> 受试者的神经病症的诊断或预后方法
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<150> GB1807178.7
<151> 2018-05-01
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Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro
165 170 175
Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu
180 185 190
Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser
195 200 205
Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly
210 215 220
Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His
225 230 235 240
Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn
245 250 255
Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg
260 265 270
Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr
275 280 285
Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu
290 295 300
Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala
305 310 315 320
Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu
325 330 335
Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp
340 345 350
Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala
355 360 365
Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys
370 375 380
Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser
385 390 395 400
Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg
405 410 415
Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser
420 425 430
Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala
435 440 445
Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile
450 455 460
Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile
465 470 475 480
Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Val Asp Lys Ser Thr Gly
485 490 495
Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys
500 505 510
Glu Asp Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu
515 520 525
Asp Glu Lys Gln Arg Asp Lys Val Ser Ser Lys Asn Ser Leu Glu Ser
530 535 540
Tyr Ala Phe Asn Met Lys Ala Thr Val Glu Asp Glu Lys Leu Gln Gly
545 550 555 560
Lys Ile Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Glu
565 570 575
Ile Ile Asn Trp Leu Asp Lys Asn Gln Thr Ala Glu Lys Glu Glu Phe
580 585 590
Glu His Gln Gln Lys Glu Leu Glu Lys Val Cys Asn Pro Ile Ile Thr
595 600 605
Lys Leu Tyr Gln Ser Ala Gly Gly Met Pro Gly Gly Met Pro Gly Gly
610 615 620
Phe Pro Gly Gly Gly Ala Pro Pro Ser Gly Gly Ala Ser Ser Gly Pro
625 630 635 640
Thr Ile Glu Glu Val Asp
645
<210> 4
<211> 398
<212> PRT
<213> 智人(Homo sapiens)
<400> 4
Met Asn Trp His Leu Pro Leu Phe Leu Leu Ala Ser Val Thr Leu Pro
1 5 10 15
Ser Ile Cys Ser His Phe Asn Pro Leu Ser Leu Glu Glu Leu Gly Ser
20 25 30
Asn Thr Gly Ile Gln Val Phe Asn Gln Ile Val Lys Ser Arg Pro His
35 40 45
Asp Asn Ile Val Ile Ser Pro His Gly Ile Ala Ser Val Leu Gly Met
50 55 60
Leu Gln Leu Gly Ala Asp Gly Arg Thr Lys Lys Gln Leu Ala Met Val
65 70 75 80
Met Arg Tyr Gly Val Asn Gly Val Gly Lys Ile Leu Lys Lys Ile Asn
85 90 95
Lys Ala Ile Val Ser Lys Lys Asn Lys Asp Ile Val Thr Val Ala Asn
100 105 110
Ala Val Phe Val Lys Asn Ala Ser Glu Ile Glu Val Pro Phe Val Thr
115 120 125
Arg Asn Lys Asp Val Phe Gln Cys Glu Val Arg Asn Val Asn Phe Glu
130 135 140
Asp Pro Ala Ser Ala Cys Asp Ser Ile Asn Ala Trp Val Lys Asn Glu
145 150 155 160
Thr Arg Asp Met Ile Asp Asn Leu Leu Ser Pro Asp Leu Ile Asp Gly
165 170 175
Val Leu Thr Arg Leu Val Leu Val Asn Ala Val Tyr Phe Lys Gly Leu
180 185 190
Trp Lys Ser Arg Phe Gln Pro Glu Asn Thr Lys Lys Arg Thr Phe Val
195 200 205
Ala Ala Asp Gly Lys Ser Tyr Gln Val Pro Met Leu Ala Gln Leu Ser
210 215 220
Val Phe Arg Cys Gly Ser Thr Ser Ala Pro Asn Asp Leu Trp Tyr Asn
225 230 235 240
Phe Ile Glu Leu Pro Tyr His Gly Glu Ser Ile Ser Met Leu Ile Ala
245 250 255
Leu Pro Thr Glu Ser Ser Thr Pro Leu Ser Ala Ile Ile Pro His Ile
260 265 270
Ser Thr Lys Thr Ile Asp Ser Trp Met Ser Ile Met Val Pro Lys Arg
275 280 285
Val Gln Val Ile Leu Pro Lys Phe Thr Ala Val Ala Gln Thr Asp Leu
290 295 300
Lys Glu Pro Leu Lys Val Leu Gly Ile Thr Asp Met Phe Asp Ser Ser
305 310 315 320
Lys Ala Asn Phe Ala Lys Ile Thr Thr Gly Ser Glu Asn Leu His Val
325 330 335
Ser His Ile Leu Gln Lys Ala Lys Ile Glu Val Ser Glu Asp Gly Thr
340 345 350
Lys Ala Ser Ala Ala Thr Thr Ala Ile Leu Ile Ala Arg Ser Ser Pro
355 360 365
Pro Trp Phe Ile Val Asp Arg Pro Phe Leu Phe Phe Ile Arg His Asn
370 375 380
Pro Thr Gly Ala Val Leu Phe Met Gly Gln Ile Asn Lys Pro
385 390 395
<210> 5
<211> 4684
<212> PRT
<213> 智人(Homo sapiens)
<400> 5
Met Val Ala Gly Met Leu Met Pro Arg Asp Gln Leu Arg Ala Ile Tyr
1 5 10 15
Glu Val Leu Phe Arg Glu Gly Val Met Val Ala Lys Lys Asp Arg Arg
20 25 30
Pro Arg Ser Leu His Pro His Val Pro Gly Val Thr Asn Leu Gln Val
35 40 45
Met Arg Ala Met Ala Ser Leu Arg Ala Arg Gly Leu Val Arg Glu Thr
50 55 60
Phe Ala Trp Cys His Phe Tyr Trp Tyr Leu Thr Asn Glu Gly Ile Ala
65 70 75 80
His Leu Arg Gln Tyr Leu His Leu Pro Pro Glu Ile Val Pro Ala Ser
85 90 95
Leu Gln Arg Val Arg Arg Pro Val Ala Met Val Met Pro Ala Arg Arg
100 105 110
Thr Pro His Val Gln Ala Val Gln Gly Pro Leu Gly Ser Pro Pro Lys
115 120 125
Arg Gly Pro Leu Pro Thr Glu Glu Gln Arg Val Tyr Arg Arg Lys Glu
130 135 140
Leu Glu Glu Val Ser Pro Glu Thr Pro Val Val Pro Ala Thr Thr Gln
145 150 155 160
Arg Thr Leu Ala Arg Pro Gly Pro Glu Pro Ala Pro Ala Thr Asp Glu
165 170 175
Arg Asp Arg Val Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Lys His
180 185 190
Leu Ile Lys Ala Gln Arg His Ile Ser Asp Leu Tyr Glu Asp Leu Arg
195 200 205
Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly Asp Ser
210 215 220
Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Lys Leu Gln Asn Val
225 230 235 240
Gln Ile Ala Leu Asp Tyr Leu Arg His Arg Gln Val Lys Leu Val Asn
245 250 255
Ile Arg Asn Asp Asp Ile Ala Asp Gly Asn Pro Lys Leu Thr Leu Gly
260 265 270
Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile Gln Val
275 280 285
Ser Gly Gln Ser Glu Asp Met Thr Ala Lys Glu Lys Leu Leu Leu Trp
290 295 300
Ser Gln Arg Met Val Glu Gly Tyr Gln Gly Leu Arg Cys Asp Asn Phe
305 310 315 320
Thr Ser Ser Trp Arg Asp Gly Arg Leu Phe Asn Ala Ile Ile His Arg
325 330 335
His Lys Pro Leu Leu Ile Asp Met Asn Lys Val Tyr Arg Gln Thr Asn
340 345 350
Leu Glu Asn Leu Asp Gln Ala Phe Ser Val Ala Glu Arg Asp Leu Gly
355 360 365
Val Thr Arg Leu Leu Asp Pro Glu Asp Val Asp Val Pro Gln Pro Asp
370 375 380
Glu Lys Ser Ile Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Met Pro
385 390 395 400
Arg Val Pro Asp Val Gln Asp Gly Val Arg Ala Asn Glu Leu Gln Leu
405 410 415
Arg Trp Gln Glu Tyr Arg Glu Leu Val Leu Leu Leu Leu Gln Trp Met
420 425 430
Arg His His Thr Ala Ala Phe Glu Glu Arg Arg Phe Pro Ser Ser Phe
435 440 445
Glu Glu Ile Glu Ile Leu Trp Ser Gln Phe Leu Lys Phe Lys Glu Met
450 455 460
Glu Leu Pro Ala Lys Glu Ala Asp Lys Asn Arg Ser Lys Gly Ile Tyr
465 470 475 480
Gln Ser Leu Glu Gly Ala Val Gln Ala Gly Gln Leu Lys Val Pro Pro
485 490 495
Gly Tyr His Pro Leu Asp Val Glu Lys Glu Trp Gly Lys Leu His Val
500 505 510
Ala Ile Leu Glu Arg Glu Lys Gln Leu Arg Ser Glu Phe Glu Arg Leu
515 520 525
Glu Cys Leu Gln Arg Ile Val Thr Lys Leu Gln Met Glu Ala Gly Leu
530 535 540
Cys Glu Glu Gln Leu Asn Gln Ala Asp Ala Leu Leu Gln Ser Asp Val
545 550 555 560
Arg Leu Leu Ala Ala Gly Lys Val Pro Gln Arg Ala Gly Glu Val Glu
565 570 575
Arg Asp Leu Asp Lys Ala Asp Ser Met Ile Arg Leu Leu Phe Asn Asp
580 585 590
Val Gln Thr Leu Lys Asp Gly Arg His Pro Gln Gly Glu Gln Met Tyr
595 600 605
Arg Arg Val Tyr Arg Leu His Glu Arg Leu Val Ala Ile Arg Thr Glu
610 615 620
Tyr Asn Leu Arg Leu Lys Ala Gly Val Ala Ala Pro Ala Thr Gln Val
625 630 635 640
Ala Gln Val Thr Leu Gln Ser Val Gln Arg Arg Pro Glu Leu Glu Asp
645 650 655
Ser Thr Leu Arg Tyr Leu Gln Asp Leu Leu Ala Trp Val Glu Glu Asn
660 665 670
Gln His Arg Val Asp Gly Ala Glu Trp Gly Val Asp Leu Pro Ser Val
675 680 685
Glu Ala Gln Leu Gly Ser His Arg Gly Leu His Gln Ser Ile Glu Glu
690 695 700
Phe Arg Ala Lys Ile Glu Arg Ala Arg Ser Asp Glu Gly Gln Leu Ser
705 710 715 720
Pro Ala Thr Arg Gly Ala Tyr Arg Asp Cys Leu Gly Arg Leu Asp Leu
725 730 735
Gln Tyr Ala Lys Leu Leu Asn Ser Ser Lys Ala Arg Leu Arg Ser Leu
740 745 750
Glu Ser Leu His Ser Phe Val Ala Ala Ala Thr Lys Glu Leu Met Trp
755 760 765
Leu Asn Glu Lys Glu Glu Glu Glu Val Gly Phe Asp Trp Ser Asp Arg
770 775 780
Asn Thr Asn Met Thr Ala Lys Lys Glu Ser Tyr Ser Ala Leu Met Arg
785 790 795 800
Glu Leu Glu Leu Lys Glu Lys Lys Ile Lys Glu Leu Gln Asn Ala Gly
805 810 815
Asp Arg Leu Leu Arg Glu Asp His Pro Ala Arg Pro Thr Val Glu Ser
820 825 830
Phe Gln Ala Ala Leu Gln Thr Gln Trp Ser Trp Met Leu Gln Leu Cys
835 840 845
Cys Cys Ile Glu Ala His Leu Lys Glu Asn Ala Ala Tyr Phe Gln Phe
850 855 860
Phe Ser Asp Val Arg Glu Ala Glu Gly Gln Leu Gln Lys Leu Gln Glu
865 870 875 880
Ala Leu Arg Arg Lys Tyr Ser Cys Asp Arg Ser Ala Thr Val Thr Arg
885 890 895
Leu Glu Asp Leu Leu Gln Asp Ala Gln Asp Glu Lys Glu Gln Leu Asn
900 905 910
Glu Tyr Lys Gly His Leu Ser Gly Leu Ala Lys Arg Ala Lys Ala Val
915 920 925
Val Gln Leu Lys Pro Arg His Pro Ala His Pro Met Arg Gly Arg Leu
930 935 940
Pro Leu Leu Ala Val Cys Asp Tyr Lys Gln Val Glu Val Thr Val His
945 950 955 960
Lys Gly Asp Glu Cys Gln Leu Val Gly Pro Ala Gln Pro Ser His Trp
965 970 975
Lys Val Leu Ser Ser Ser Gly Ser Glu Ala Ala Val Pro Ser Val Cys
980 985 990
Phe Leu Val Pro Pro Pro Asn Gln Glu Ala Gln Glu Ala Val Thr Arg
995 1000 1005
Leu Glu Ala Gln His Gln Ala Leu Val Thr Leu Trp His Gln Leu
1010 1015 1020
His Val Asp Met Lys Ser Leu Leu Ala Trp Gln Ser Leu Arg Arg
1025 1030 1035
Asp Val Gln Leu Ile Arg Ser Trp Ser Leu Ala Thr Phe Arg Thr
1040 1045 1050
Leu Lys Pro Glu Glu Gln Arg Gln Ala Leu His Ser Leu Glu Leu
1055 1060 1065
His Tyr Gln Ala Phe Leu Arg Asp Ser Gln Asp Ala Gly Gly Phe
1070 1075 1080
Gly Pro Glu Asp Arg Leu Met Ala Glu Arg Glu Tyr Gly Ser Cys
1085 1090 1095
Ser His His Tyr Gln Gln Leu Leu Gln Ser Leu Glu Gln Gly Ala
1100 1105 1110
Gln Glu Glu Ser Arg Cys Gln Arg Cys Ile Ser Glu Leu Lys Asp
1115 1120 1125
Ile Arg Leu Gln Leu Glu Ala Cys Glu Thr Arg Thr Val His Arg
1130 1135 1140
Leu Arg Leu Pro Leu Asp Lys Glu Pro Ala Arg Glu Cys Ala Gln
1145 1150 1155
Arg Ile Ala Glu Gln Gln Lys Ala Gln Ala Glu Val Glu Gly Leu
1160 1165 1170
Gly Lys Gly Val Ala Arg Leu Ser Ala Glu Ala Glu Lys Val Leu
1175 1180 1185
Ala Leu Pro Glu Pro Ser Pro Ala Ala Pro Thr Leu Arg Ser Glu
1190 1195 1200
Leu Glu Leu Thr Leu Gly Lys Leu Glu Gln Val Arg Ser Leu Ser
1205 1210 1215
Ala Ile Tyr Leu Glu Lys Leu Lys Thr Ile Ser Leu Val Ile Arg
1220 1225 1230
Gly Thr Gln Gly Ala Glu Glu Val Leu Arg Ala His Glu Glu Gln
1235 1240 1245
Leu Lys Glu Ala Gln Ala Val Pro Ala Thr Leu Pro Glu Leu Glu
1250 1255 1260
Ala Thr Lys Ala Ser Leu Lys Lys Leu Arg Ala Gln Ala Glu Ala
1265 1270 1275
Gln Gln Pro Thr Phe Asp Ala Leu Arg Asp Glu Leu Arg Gly Ala
1280 1285 1290
Gln Glu Val Gly Glu Arg Leu Gln Gln Arg His Gly Glu Arg Asp
1295 1300 1305
Val Glu Val Glu Arg Trp Arg Glu Arg Val Ala Gln Leu Leu Glu
1310 1315 1320
Arg Trp Gln Ala Val Leu Ala Gln Thr Asp Val Arg Gln Arg Glu
1325 1330 1335
Leu Glu Gln Leu Gly Arg Gln Leu Arg Tyr Tyr Arg Glu Ser Ala
1340 1345 1350
Asp Pro Leu Gly Ala Trp Leu Gln Asp Ala Arg Arg Arg Gln Glu
1355 1360 1365
Gln Ile Gln Ala Met Pro Leu Ala Asp Ser Gln Ala Val Arg Glu
1370 1375 1380
Gln Leu Arg Gln Glu Gln Ala Leu Leu Glu Glu Ile Glu Arg His
1385 1390 1395
Gly Glu Lys Val Glu Glu Cys Gln Arg Phe Ala Lys Gln Tyr Ile
1400 1405 1410
Asn Ala Ile Lys Asp Tyr Glu Leu Gln Leu Val Thr Tyr Lys Ala
1415 1420 1425
Gln Leu Glu Pro Val Ala Ser Pro Ala Lys Lys Pro Lys Val Gln
1430 1435 1440
Ser Gly Ser Glu Ser Val Ile Gln Glu Tyr Val Asp Leu Arg Thr
1445 1450 1455
His Tyr Ser Glu Leu Thr Thr Leu Thr Ser Gln Tyr Ile Lys Phe
1460 1465 1470
Ile Ser Glu Thr Leu Arg Arg Met Glu Glu Glu Glu Arg Leu Ala
1475 1480 1485
Glu Gln Gln Arg Ala Glu Glu Arg Glu Arg Leu Ala Glu Val Glu
1490 1495 1500
Ala Ala Leu Glu Lys Gln Arg Gln Leu Ala Glu Ala His Ala Gln
1505 1510 1515
Ala Lys Ala Gln Ala Glu Arg Glu Ala Lys Glu Leu Gln Gln Arg
1520 1525 1530
Met Gln Glu Glu Val Val Arg Arg Glu Glu Ala Ala Val Asp Ala
1535 1540 1545
Gln Gln Gln Lys Arg Ser Ile Gln Glu Glu Leu Gln Gln Leu Arg
1550 1555 1560
Gln Ser Ser Glu Ala Glu Ile Gln Ala Lys Ala Arg Gln Ala Glu
1565 1570 1575
Ala Ala Glu Arg Ser Arg Leu Arg Ile Glu Glu Glu Ile Arg Val
1580 1585 1590
Val Arg Leu Gln Leu Glu Ala Thr Glu Arg Gln Arg Gly Gly Ala
1595 1600 1605
Glu Gly Glu Leu Gln Ala Leu Arg Ala Arg Ala Glu Glu Ala Glu
1610 1615 1620
Ala Gln Lys Arg Gln Ala Gln Glu Glu Ala Glu Arg Leu Arg Arg
1625 1630 1635
Gln Val Gln Asp Glu Ser Gln Arg Lys Arg Gln Ala Glu Val Glu
1640 1645 1650
Leu Ala Ser Arg Val Lys Ala Glu Ala Glu Ala Ala Arg Glu Lys
1655 1660 1665
Gln Arg Ala Leu Gln Ala Leu Glu Glu Leu Arg Leu Gln Ala Glu
1670 1675 1680
Glu Ala Glu Arg Arg Leu Arg Gln Ala Glu Val Glu Arg Ala Arg
1685 1690 1695
Gln Val Gln Val Ala Leu Glu Thr Ala Gln Arg Ser Ala Glu Ala
1700 1705 1710
Glu Leu Gln Ser Lys Arg Ala Ser Phe Ala Glu Lys Thr Ala Gln
1715 1720 1725
Leu Glu Arg Ser Leu Gln Glu Glu His Val Ala Val Ala Gln Leu
1730 1735 1740
Arg Glu Glu Ala Glu Arg Arg Ala Gln Gln Gln Ala Glu Ala Glu
1745 1750 1755
Arg Ala Arg Glu Glu Ala Glu Arg Glu Leu Glu Arg Trp Gln Leu
1760 1765 1770
Lys Ala Asn Glu Ala Leu Arg Leu Arg Leu Gln Ala Glu Glu Val
1775 1780 1785
Ala Gln Gln Lys Ser Leu Ala Gln Ala Glu Ala Glu Lys Gln Lys
1790 1795 1800
Glu Glu Ala Glu Arg Glu Ala Arg Arg Arg Gly Lys Ala Glu Glu
1805 1810 1815
Gln Ala Val Arg Gln Arg Glu Leu Ala Glu Gln Glu Leu Glu Lys
1820 1825 1830
Gln Arg Gln Leu Ala Glu Gly Thr Ala Gln Gln Arg Leu Ala Ala
1835 1840 1845
Glu Gln Glu Leu Ile Arg Leu Arg Ala Glu Thr Glu Gln Gly Glu
1850 1855 1860
Gln Gln Arg Gln Leu Leu Glu Glu Glu Leu Ala Arg Leu Gln Arg
1865 1870 1875
Glu Ala Ala Ala Ala Thr Gln Lys Arg Gln Glu Leu Glu Ala Glu
1880 1885 1890
Leu Ala Lys Val Arg Ala Glu Met Glu Val Leu Leu Ala Ser Lys
1895 1900 1905
Ala Arg Ala Glu Glu Glu Ser Arg Ser Thr Ser Glu Lys Ser Lys
1910 1915 1920
Gln Arg Leu Glu Ala Glu Ala Gly Arg Phe Arg Glu Leu Ala Glu
1925 1930 1935
Glu Ala Ala Arg Leu Arg Ala Leu Ala Glu Glu Ala Lys Arg Gln
1940 1945 1950
Arg Gln Leu Ala Glu Glu Asp Ala Ala Arg Gln Arg Ala Glu Ala
1955 1960 1965
Glu Arg Val Leu Ala Glu Lys Leu Ala Ala Ile Gly Glu Ala Thr
1970 1975 1980
Arg Leu Lys Thr Glu Ala Glu Ile Ala Leu Lys Glu Lys Glu Ala
1985 1990 1995
Glu Asn Glu Arg Leu Arg Arg Leu Ala Glu Asp Glu Ala Phe Gln
2000 2005 2010
Arg Arg Arg Leu Glu Glu Gln Ala Ala Gln His Lys Ala Asp Ile
2015 2020 2025
Glu Glu Arg Leu Ala Gln Leu Arg Lys Ala Ser Asp Ser Glu Leu
2030 2035 2040
Glu Arg Gln Lys Gly Leu Val Glu Asp Thr Leu Arg Gln Arg Arg
2045 2050 2055
Gln Val Glu Glu Glu Ile Leu Ala Leu Lys Ala Ser Phe Glu Lys
2060 2065 2070
Ala Ala Ala Gly Lys Ala Glu Leu Glu Leu Glu Leu Gly Arg Ile
2075 2080 2085
Arg Ser Asn Ala Glu Asp Thr Leu Arg Ser Lys Glu Gln Ala Glu
2090 2095 2100
Leu Glu Ala Ala Arg Gln Arg Gln Leu Ala Ala Glu Glu Glu Arg
2105 2110 2115
Arg Arg Arg Glu Ala Glu Glu Arg Val Gln Lys Ser Leu Ala Ala
2120 2125 2130
Glu Glu Glu Ala Ala Arg Gln Arg Lys Ala Ala Leu Glu Glu Val
2135 2140 2145
Glu Arg Leu Lys Ala Lys Val Glu Glu Ala Arg Arg Leu Arg Glu
2150 2155 2160
Arg Ala Glu Gln Glu Ser Ala Arg Gln Leu Gln Leu Ala Gln Glu
2165 2170 2175
Ala Ala Gln Lys Arg Leu Gln Ala Glu Glu Lys Ala His Ala Phe
2180 2185 2190
Ala Val Gln Gln Lys Glu Gln Glu Leu Gln Gln Thr Leu Gln Gln
2195 2200 2205
Glu Gln Ser Val Leu Asp Gln Leu Arg Gly Glu Ala Glu Ala Ala
2210 2215 2220
Arg Arg Ala Ala Glu Glu Ala Glu Glu Ala Arg Val Gln Ala Glu
2225 2230 2235
Arg Glu Ala Ala Gln Ser Arg Arg Gln Val Glu Glu Ala Glu Arg
2240 2245 2250
Leu Lys Gln Ser Ala Glu Glu Gln Ala Gln Ala Arg Ala Gln Ala
2255 2260 2265
Gln Ala Ala Ala Glu Lys Leu Arg Lys Glu Ala Glu Gln Glu Ala
2270 2275 2280
Ala Arg Arg Ala Gln Ala Glu Gln Ala Ala Leu Arg Gln Lys Gln
2285 2290 2295
Ala Ala Asp Ala Glu Met Glu Lys His Lys Lys Phe Ala Glu Gln
2300 2305 2310
Thr Leu Arg Gln Lys Ala Gln Val Glu Gln Glu Leu Thr Thr Leu
2315 2320 2325
Arg Leu Gln Leu Glu Glu Thr Asp His Gln Lys Asn Leu Leu Asp
2330 2335 2340
Glu Glu Leu Gln Arg Leu Lys Ala Glu Ala Thr Glu Ala Ala Arg
2345 2350 2355
Gln Arg Ser Gln Val Glu Glu Glu Leu Phe Ser Val Arg Val Gln
2360 2365 2370
Met Glu Glu Leu Ser Lys Leu Lys Ala Arg Ile Glu Ala Glu Asn
2375 2380 2385
Arg Ala Leu Ile Leu Arg Asp Lys Asp Asn Thr Gln Arg Phe Leu
2390 2395 2400
Gln Glu Glu Ala Glu Lys Met Lys Gln Val Ala Glu Glu Ala Ala
2405 2410 2415
Arg Leu Ser Val Ala Ala Gln Glu Ala Ala Arg Leu Arg Gln Leu
2420 2425 2430
Ala Glu Glu Asp Leu Ala Gln Gln Arg Ala Leu Ala Glu Lys Met
2435 2440 2445
Leu Lys Glu Lys Met Gln Ala Val Gln Glu Ala Thr Arg Leu Lys
2450 2455 2460
Ala Glu Ala Glu Leu Leu Gln Gln Gln Lys Glu Leu Ala Gln Glu
2465 2470 2475
Gln Ala Arg Arg Leu Gln Glu Asp Lys Glu Gln Met Ala Gln Gln
2480 2485 2490
Leu Ala Glu Glu Thr Gln Gly Phe Gln Arg Thr Leu Glu Ala Glu
2495 2500 2505
Arg Gln Arg Gln Leu Glu Met Ser Ala Glu Ala Glu Arg Leu Lys
2510 2515 2520
Leu Arg Val Ala Glu Met Ser Arg Ala Gln Ala Arg Ala Glu Glu
2525 2530 2535
Asp Ala Gln Arg Phe Arg Lys Gln Ala Glu Glu Ile Gly Glu Lys
2540 2545 2550
Leu His Arg Thr Glu Leu Ala Thr Gln Glu Lys Val Thr Leu Val
2555 2560 2565
Gln Thr Leu Glu Ile Gln Arg Gln Gln Ser Asp His Asp Ala Glu
2570 2575 2580
Arg Leu Arg Glu Ala Ile Ala Glu Leu Glu Arg Glu Lys Glu Lys
2585 2590 2595
Leu Gln Gln Glu Ala Lys Leu Leu Gln Leu Lys Ser Glu Glu Met
2600 2605 2610
Gln Thr Val Gln Gln Glu Gln Leu Leu Gln Glu Thr Gln Ala Leu
2615 2620 2625
Gln Gln Ser Phe Leu Ser Glu Lys Asp Ser Leu Leu Gln Arg Glu
2630 2635 2640
Arg Phe Ile Glu Gln Glu Lys Ala Lys Leu Glu Gln Leu Phe Gln
2645 2650 2655
Asp Glu Val Ala Lys Ala Gln Gln Leu Arg Glu Glu Gln Gln Arg
2660 2665 2670
Gln Gln Gln Gln Met Glu Gln Glu Arg Gln Arg Leu Val Ala Ser
2675 2680 2685
Met Glu Glu Ala Arg Arg Arg Gln His Glu Ala Glu Glu Gly Val
2690 2695 2700
Arg Arg Lys Gln Glu Glu Leu Gln Gln Leu Glu Gln Gln Arg Arg
2705 2710 2715
Gln Gln Glu Glu Leu Leu Ala Glu Glu Asn Gln Arg Leu Arg Glu
2720 2725 2730
Gln Leu Gln Leu Leu Glu Glu Gln His Arg Ala Ala Leu Ala His
2735 2740 2745
Ser Glu Glu Val Thr Ala Ser Gln Val Ala Ala Thr Lys Thr Leu
2750 2755 2760
Pro Asn Gly Arg Asp Ala Leu Asp Gly Pro Ala Ala Glu Ala Glu
2765 2770 2775
Pro Glu His Ser Phe Asp Gly Leu Arg Arg Lys Val Ser Ala Gln
2780 2785 2790
Arg Leu Gln Glu Ala Gly Ile Leu Ser Ala Glu Glu Leu Gln Arg
2795 2800 2805
Leu Ala Gln Gly His Thr Thr Val Asp Glu Leu Ala Arg Arg Glu
2810 2815 2820
Asp Val Arg His Tyr Leu Gln Gly Arg Ser Ser Ile Ala Gly Leu
2825 2830 2835
Leu Leu Lys Ala Thr Asn Glu Lys Leu Ser Val Tyr Ala Ala Leu
2840 2845 2850
Gln Arg Gln Leu Leu Ser Pro Gly Thr Ala Leu Ile Leu Leu Glu
2855 2860 2865
Ala Gln Ala Ala Ser Gly Phe Leu Leu Asp Pro Val Arg Asn Arg
2870 2875 2880
Arg Leu Thr Val Asn Glu Ala Val Lys Glu Gly Val Val Gly Pro
2885 2890 2895
Glu Leu His His Lys Leu Leu Ser Ala Glu Arg Ala Val Thr Gly
2900 2905 2910
Tyr Lys Asp Pro Tyr Thr Gly Gln Gln Ile Ser Leu Phe Gln Ala
2915 2920 2925
Met Gln Lys Gly Leu Ile Val Arg Glu His Gly Ile Arg Leu Leu
2930 2935 2940
Glu Ala Gln Ile Ala Thr Gly Gly Val Ile Asp Pro Val His Ser
2945 2950 2955
His Arg Val Pro Val Asp Val Ala Tyr Arg Arg Gly Tyr Phe Asp
2960 2965 2970
Glu Glu Met Asn Arg Val Leu Ala Asp Pro Ser Asp Asp Thr Lys
2975 2980 2985
Gly Phe Phe Asp Pro Asn Thr His Glu Asn Leu Thr Tyr Leu Gln
2990 2995 3000
Leu Leu Glu Arg Cys Val Glu Asp Pro Glu Thr Gly Leu Cys Leu
3005 3010 3015
Leu Pro Leu Thr Asp Lys Ala Ala Lys Gly Gly Glu Leu Val Tyr
3020 3025 3030
Thr Asp Ser Glu Ala Arg Asp Val Phe Glu Lys Ala Thr Val Ser
3035 3040 3045
Ala Pro Phe Gly Lys Phe Gln Gly Lys Thr Val Thr Ile Trp Glu
3050 3055 3060
Ile Ile Asn Ser Glu Tyr Phe Thr Ala Glu Gln Arg Arg Asp Leu
3065 3070 3075
Leu Arg Gln Phe Arg Thr Gly Arg Ile Thr Val Glu Lys Ile Ile
3080 3085 3090
Lys Ile Ile Ile Thr Val Val Glu Glu Gln Glu Gln Lys Gly Arg
3095 3100 3105
Leu Cys Phe Glu Gly Leu Arg Ser Leu Val Pro Ala Ala Glu Leu
3110 3115 3120
Leu Glu Ser Arg Val Ile Asp Arg Glu Leu Tyr Gln Gln Leu Gln
3125 3130 3135
Arg Gly Glu Arg Ser Val Arg Asp Val Ala Glu Val Asp Thr Val
3140 3145 3150
Arg Arg Ala Leu Arg Gly Ala Asn Val Ile Ala Gly Val Trp Leu
3155 3160 3165
Glu Glu Ala Gly Gln Lys Leu Ser Ile Tyr Asn Ala Leu Lys Lys
3170 3175 3180
Asp Leu Leu Pro Ser Asp Met Ala Val Ala Leu Leu Glu Ala Gln
3185 3190 3195
Ala Gly Thr Gly His Ile Ile Asp Pro Ala Thr Ser Ala Arg Leu
3200 3205 3210
Thr Val Asp Glu Ala Val Arg Ala Gly Leu Val Gly Pro Glu Phe
3215 3220 3225
His Glu Lys Leu Leu Ser Ala Glu Lys Ala Val Thr Gly Tyr Arg
3230 3235 3240
Asp Pro Tyr Thr Gly Gln Ser Val Ser Leu Phe Gln Ala Leu Lys
3245 3250 3255
Lys Gly Leu Ile Pro Arg Glu Gln Gly Leu Arg Leu Leu Asp Ala
3260 3265 3270
Gln Leu Ser Thr Gly Gly Ile Val Asp Pro Ser Lys Ser His Arg
3275 3280 3285
Val Pro Leu Asp Val Ala Cys Ala Arg Gly Cys Leu Asp Glu Glu
3290 3295 3300
Thr Ser Arg Ala Leu Ser Ala Pro Arg Ala Asp Ala Lys Ala Tyr
3305 3310 3315
Ser Asp Pro Ser Thr Gly Glu Pro Ala Thr Tyr Gly Glu Leu Gln
3320 3325 3330
Gln Arg Cys Arg Pro Asp Gln Leu Thr Gly Leu Ser Leu Leu Pro
3335 3340 3345
Leu Ser Glu Lys Ala Ala Arg Ala Arg Gln Glu Glu Leu Tyr Ser
3350 3355 3360
Glu Leu Gln Ala Arg Glu Thr Phe Glu Lys Thr Pro Val Glu Val
3365 3370 3375
Pro Val Gly Gly Phe Lys Gly Arg Thr Val Thr Val Trp Glu Leu
3380 3385 3390
Ile Ser Ser Glu Tyr Phe Thr Ala Glu Gln Arg Gln Glu Leu Leu
3395 3400 3405
Arg Gln Phe Arg Thr Gly Lys Val Thr Val Glu Lys Val Ile Lys
3410 3415 3420
Ile Leu Ile Thr Ile Val Glu Glu Val Glu Thr Leu Arg Gln Glu
3425 3430 3435
Arg Leu Ser Phe Ser Gly Leu Arg Ala Pro Val Pro Ala Ser Glu
3440 3445 3450
Leu Leu Ala Ser Gly Val Leu Ser Arg Ala Gln Phe Glu Gln Leu
3455 3460 3465
Lys Asp Gly Lys Thr Thr Val Lys Asp Leu Ser Glu Leu Gly Ser
3470 3475 3480
Val Arg Thr Leu Leu Gln Gly Ser Gly Cys Leu Ala Gly Ile Tyr
3485 3490 3495
Leu Glu Asp Thr Lys Glu Lys Val Ser Ile Tyr Glu Ala Met Arg
3500 3505 3510
Arg Gly Leu Leu Arg Ala Thr Thr Ala Ala Leu Leu Leu Glu Ala
3515 3520 3525
Gln Ala Ala Thr Gly Phe Leu Val Asp Pro Val Arg Asn Gln Arg
3530 3535 3540
Leu Tyr Val His Glu Ala Val Lys Ala Gly Val Val Gly Pro Glu
3545 3550 3555
Leu His Glu Gln Leu Leu Ser Ala Glu Lys Ala Val Thr Gly Tyr
3560 3565 3570
Arg Asp Pro Tyr Ser Gly Ser Thr Ile Ser Leu Phe Gln Ala Met
3575 3580 3585
Gln Lys Gly Leu Val Leu Arg Gln His Gly Ile Arg Leu Leu Glu
3590 3595 3600
Ala Gln Ile Ala Thr Gly Gly Ile Ile Asp Pro Val His Ser His
3605 3610 3615
Arg Val Pro Val Asp Val Ala Tyr Gln Arg Gly Tyr Phe Ser Glu
3620 3625 3630
Glu Met Asn Arg Val Leu Ala Asp Pro Ser Asp Asp Thr Lys Gly
3635 3640 3645
Phe Phe Asp Pro Asn Thr His Glu Asn Leu Thr Tyr Arg Gln Leu
3650 3655 3660
Leu Glu Arg Cys Val Glu Asp Pro Glu Thr Gly Leu Arg Leu Leu
3665 3670 3675
Pro Leu Lys Gly Ala Glu Lys Ala Glu Val Val Glu Thr Thr Gln
3680 3685 3690
Val Tyr Thr Glu Glu Glu Thr Arg Arg Ala Phe Glu Glu Thr Gln
3695 3700 3705
Ile Asp Ile Pro Gly Gly Gly Ser His Gly Gly Ser Thr Met Ser
3710 3715 3720
Leu Trp Glu Val Met Gln Ser Asp Leu Ile Pro Glu Glu Gln Arg
3725 3730 3735
Ala Gln Leu Met Ala Asp Phe Gln Ala Gly Arg Val Thr Lys Glu
3740 3745 3750
Arg Met Ile Ile Ile Ile Ile Glu Ile Ile Glu Lys Thr Glu Ile
3755 3760 3765
Ile Arg Gln Gln Gly Leu Ala Ser Tyr Asp Tyr Val Arg Arg Arg
3770 3775 3780
Leu Thr Ala Glu Asp Leu Phe Glu Ala Arg Ile Ile Ser Leu Glu
3785 3790 3795
Thr Tyr Asn Leu Leu Arg Glu Gly Thr Arg Ser Leu Arg Glu Ala
3800 3805 3810
Leu Glu Ala Glu Ser Ala Trp Cys Tyr Leu Tyr Gly Thr Gly Ser
3815 3820 3825
Val Ala Gly Val Tyr Leu Pro Gly Ser Arg Gln Thr Leu Ser Ile
3830 3835 3840
Tyr Gln Ala Leu Lys Lys Gly Leu Leu Ser Ala Glu Val Ala Arg
3845 3850 3855
Leu Leu Leu Glu Ala Gln Ala Ala Thr Gly Phe Leu Leu Asp Pro
3860 3865 3870
Val Lys Gly Glu Arg Leu Thr Val Asp Glu Ala Val Arg Lys Gly
3875 3880 3885
Leu Val Gly Pro Glu Leu His Asp Arg Leu Leu Ser Ala Glu Arg
3890 3895 3900
Ala Val Thr Gly Tyr Arg Asp Pro Tyr Thr Glu Gln Thr Ile Ser
3905 3910 3915
Leu Phe Gln Ala Met Lys Lys Glu Leu Ile Pro Thr Glu Glu Ala
3920 3925 3930
Leu Arg Leu Leu Asp Ala Gln Leu Ala Thr Gly Gly Ile Val Asp
3935 3940 3945
Pro Arg Leu Gly Phe His Leu Pro Leu Glu Val Ala Tyr Gln Arg
3950 3955 3960
Gly Tyr Leu Asn Lys Asp Thr His Asp Gln Leu Ser Glu Pro Ser
3965 3970 3975
Glu Val Arg Ser Tyr Val Asp Pro Ser Thr Asp Glu Arg Leu Ser
3980 3985 3990
Tyr Thr Gln Leu Leu Arg Arg Cys Arg Arg Asp Asp Gly Thr Gly
3995 4000 4005
Gln Leu Leu Leu Pro Leu Ser Asp Ala Arg Lys Leu Thr Phe Arg
4010 4015 4020
Gly Leu Arg Lys Gln Ile Thr Met Glu Glu Leu Val Arg Ser Gln
4025 4030 4035
Val Met Asp Glu Ala Thr Ala Leu Gln Leu Arg Glu Gly Leu Thr
4040 4045 4050
Ser Ile Glu Glu Val Thr Lys Asn Leu Gln Lys Phe Leu Glu Gly
4055 4060 4065
Thr Ser Cys Ile Ala Gly Val Phe Val Asp Ala Thr Lys Glu Arg
4070 4075 4080
Leu Ser Val Tyr Gln Ala Met Lys Lys Gly Ile Ile Arg Pro Gly
4085 4090 4095
Thr Ala Phe Glu Leu Leu Glu Ala Gln Ala Ala Thr Gly Tyr Val
4100 4105 4110
Ile Asp Pro Ile Lys Gly Leu Lys Leu Thr Val Glu Glu Ala Val
4115 4120 4125
Arg Met Gly Ile Val Gly Pro Glu Phe Lys Asp Lys Leu Leu Ser
4130 4135 4140
Ala Glu Arg Ala Val Thr Gly Tyr Lys Asp Pro Tyr Ser Gly Lys
4145 4150 4155
Leu Ile Ser Leu Phe Gln Ala Met Lys Lys Gly Leu Ile Leu Lys
4160 4165 4170
Asp His Gly Ile Arg Leu Leu Glu Ala Gln Ile Ala Thr Gly Gly
4175 4180 4185
Ile Ile Asp Pro Glu Glu Ser His Arg Leu Pro Val Glu Val Ala
4190 4195 4200
Tyr Lys Arg Gly Leu Phe Asp Glu Glu Met Asn Glu Ile Leu Thr
4205 4210 4215
Asp Pro Ser Asp Asp Thr Lys Gly Phe Phe Asp Pro Asn Thr Glu
4220 4225 4230
Glu Asn Leu Thr Tyr Leu Gln Leu Met Glu Arg Cys Ile Thr Asp
4235 4240 4245
Pro Gln Thr Gly Leu Cys Leu Leu Pro Leu Lys Glu Lys Lys Arg
4250 4255 4260
Glu Arg Lys Thr Ser Ser Lys Ser Ser Val Arg Lys Arg Arg Val
4265 4270 4275
Val Ile Val Asp Pro Glu Thr Gly Lys Glu Met Ser Val Tyr Glu
4280 4285 4290
Ala Tyr Arg Lys Gly Leu Ile Asp His Gln Thr Tyr Leu Glu Leu
4295 4300 4305
Ser Glu Gln Glu Cys Glu Trp Glu Glu Ile Thr Ile Ser Ser Ser
4310 4315 4320
Asp Gly Val Val Lys Ser Met Ile Ile Asp Arg Arg Ser Gly Arg
4325 4330 4335
Gln Tyr Asp Ile Asp Asp Ala Ile Ala Lys Asn Leu Ile Asp Arg
4340 4345 4350
Ser Ala Leu Asp Gln Tyr Arg Ala Gly Thr Leu Ser Ile Thr Glu
4355 4360 4365
Phe Ala Asp Met Leu Ser Gly Asn Ala Gly Gly Phe Arg Ser Arg
4370 4375 4380
Ser Ser Ser Val Gly Ser Ser Ser Ser Tyr Pro Ile Ser Pro Ala
4385 4390 4395
Val Ser Arg Thr Gln Leu Ala Ser Trp Ser Asp Pro Thr Glu Glu
4400 4405 4410
Thr Gly Pro Val Ala Gly Ile Leu Asp Thr Glu Thr Leu Glu Lys
4415 4420 4425
Val Ser Ile Thr Glu Ala Met His Arg Asn Leu Val Asp Asn Ile
4430 4435 4440
Thr Gly Gln Arg Leu Leu Glu Ala Gln Ala Cys Thr Gly Gly Ile
4445 4450 4455
Ile Asp Pro Ser Thr Gly Glu Arg Phe Pro Val Thr Asp Ala Val
4460 4465 4470
Asn Lys Gly Leu Val Asp Lys Ile Met Val Asp Arg Ile Asn Leu
4475 4480 4485
Ala Gln Lys Ala Phe Cys Gly Phe Glu Asp Pro Arg Thr Lys Thr
4490 4495 4500
Lys Met Ser Ala Ala Gln Ala Leu Lys Lys Gly Trp Leu Tyr Tyr
4505 4510 4515
Glu Ala Gly Gln Arg Phe Leu Glu Val Gln Tyr Leu Thr Gly Gly
4520 4525 4530
Leu Ile Glu Pro Asp Thr Pro Gly Arg Val Pro Leu Asp Glu Ala
4535 4540 4545
Leu Gln Arg Gly Thr Val Asp Ala Arg Thr Ala Gln Lys Leu Arg
4550 4555 4560
Asp Val Gly Ala Tyr Ser Lys Tyr Leu Thr Cys Pro Lys Thr Lys
4565 4570 4575
Leu Lys Ile Ser Tyr Lys Asp Ala Leu Asp Arg Ser Met Val Glu
4580 4585 4590
Glu Gly Thr Gly Leu Arg Leu Leu Glu Ala Ala Ala Gln Ser Thr
4595 4600 4605
Lys Gly Tyr Tyr Ser Pro Tyr Ser Val Ser Gly Ser Gly Ser Thr
4610 4615 4620
Ala Gly Ser Arg Thr Gly Ser Arg Thr Gly Ser Arg Ala Gly Ser
4625 4630 4635
Arg Arg Gly Ser Phe Asp Ala Thr Gly Ser Gly Phe Ser Met Thr
4640 4645 4650
Phe Ser Ser Ser Ser Tyr Ser Ser Ser Gly Tyr Gly Arg Arg Tyr
4655 4660 4665
Ala Ser Gly Ser Ser Ala Ser Leu Gly Gly Pro Glu Ser Ala Val
4670 4675 4680
Ala
<210> 6
<211> 654
<212> PRT
<213> 智人(Homo sapiens)
<400> 6
Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala
1 5 10 15
Arg Ala Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly
20 25 30
Ile Asp Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly
35 40 45
Arg Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser
50 55 60
Tyr Val Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala
65 70 75 80
Lys Asn Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys
85 90 95
Arg Leu Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile
100 105 110
Lys Phe Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile
115 120 125
Gln Val Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu
130 135 140
Ile Ser Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr
145 150 155 160
Leu Gly Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe
165 170 175
Asn Asp Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly
180 185 190
Leu Asn Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala
195 200 205
Tyr Gly Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp
210 215 220
Leu Gly Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly
225 230 235 240
Val Phe Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu
245 250 255
Asp Phe Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys
260 265 270
Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu
275 280 285
Arg Arg Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln
290 295 300
Ala Arg Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu
305 310 315 320
Thr Leu Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg
325 330 335
Ser Thr Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys
340 345 350
Lys Ser Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile
355 360 365
Pro Lys Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro
370 375 380
Ser Arg Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val
385 390 395 400
Gln Ala Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val Leu
405 410 415
Leu Asp Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val
420 425 430
Met Thr Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys Ser
435 440 445
Gln Ile Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys
450 455 460
Val Tyr Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly
465 470 475 480
Thr Phe Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln
485 490 495
Ile Glu Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr
500 505 510
Ala Glu Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn
515 520 525
Asp Gln Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp
530 535 540
Ala Glu Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp
545 550 555 560
Thr Arg Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile
565 570 575
Gly Asp Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu
580 585 590
Thr Met Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His
595 600 605
Gln Asp Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu
610 615 620
Glu Ile Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro
625 630 635 640
Pro Pro Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu
645 650
<210> 7
<211> 710
<212> PRT
<213> 智人(Homo sapiens)
<400> 7
Met Val Lys Leu Ala Lys Ala Gly Lys Asn Gln Gly Asp Pro Lys Lys
1 5 10 15
Met Ala Pro Pro Pro Lys Glu Val Glu Glu Asp Ser Glu Asp Glu Glu
20 25 30
Met Ser Glu Asp Glu Glu Asp Asp Ser Ser Gly Glu Glu Val Val Ile
35 40 45
Pro Gln Lys Lys Gly Lys Lys Ala Ala Ala Thr Ser Ala Lys Lys Val
50 55 60
Val Val Ser Pro Thr Lys Lys Val Ala Val Ala Thr Pro Ala Lys Lys
65 70 75 80
Ala Ala Val Thr Pro Gly Lys Lys Ala Ala Ala Thr Pro Ala Lys Lys
85 90 95
Thr Val Thr Pro Ala Lys Ala Val Thr Thr Pro Gly Lys Lys Gly Ala
100 105 110
Thr Pro Gly Lys Ala Leu Val Ala Thr Pro Gly Lys Lys Gly Ala Ala
115 120 125
Ile Pro Ala Lys Gly Ala Lys Asn Gly Lys Asn Ala Lys Lys Glu Asp
130 135 140
Ser Asp Glu Glu Glu Asp Asp Asp Ser Glu Glu Asp Glu Glu Asp Asp
145 150 155 160
Glu Asp Glu Asp Glu Asp Glu Asp Glu Ile Glu Pro Ala Ala Met Lys
165 170 175
Ala Ala Ala Ala Ala Pro Ala Ser Glu Asp Glu Asp Asp Glu Asp Asp
180 185 190
Glu Asp Asp Glu Asp Asp Asp Asp Asp Glu Glu Asp Asp Ser Glu Glu
195 200 205
Glu Ala Met Glu Thr Thr Pro Ala Lys Gly Lys Lys Ala Ala Lys Val
210 215 220
Val Pro Val Lys Ala Lys Asn Val Ala Glu Asp Glu Asp Glu Glu Glu
225 230 235 240
Asp Asp Glu Asp Glu Asp Asp Asp Asp Asp Glu Asp Asp Glu Asp Asp
245 250 255
Asp Asp Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro
260 265 270
Val Lys Glu Ala Pro Gly Lys Arg Lys Lys Glu Met Ala Lys Gln Lys
275 280 285
Ala Ala Pro Glu Ala Lys Lys Gln Lys Val Glu Gly Thr Glu Pro Thr
290 295 300
Thr Ala Phe Asn Leu Phe Val Gly Asn Leu Asn Phe Asn Lys Ser Ala
305 310 315 320
Pro Glu Leu Lys Thr Gly Ile Ser Asp Val Phe Ala Lys Asn Asp Leu
325 330 335
Ala Val Val Asp Val Arg Ile Gly Met Thr Arg Lys Phe Gly Tyr Val
340 345 350
Asp Phe Glu Ser Ala Glu Asp Leu Glu Lys Ala Leu Glu Leu Thr Gly
355 360 365
Leu Lys Val Phe Gly Asn Glu Ile Lys Leu Glu Lys Pro Lys Gly Lys
370 375 380
Asp Ser Lys Lys Glu Arg Asp Ala Arg Thr Leu Leu Ala Lys Asn Leu
385 390 395 400
Pro Tyr Lys Val Thr Gln Asp Glu Leu Lys Glu Val Phe Glu Asp Ala
405 410 415
Ala Glu Ile Arg Leu Val Ser Lys Asp Gly Lys Ser Lys Gly Ile Ala
420 425 430
Tyr Ile Glu Phe Lys Thr Glu Ala Asp Ala Glu Lys Thr Phe Glu Glu
435 440 445
Lys Gln Gly Thr Glu Ile Asp Gly Arg Ser Ile Ser Leu Tyr Tyr Thr
450 455 460
Gly Glu Lys Gly Gln Asn Gln Asp Tyr Arg Gly Gly Lys Asn Ser Thr
465 470 475 480
Trp Ser Gly Glu Ser Lys Thr Leu Val Leu Ser Asn Leu Ser Tyr Ser
485 490 495
Ala Thr Glu Glu Thr Leu Gln Glu Val Phe Glu Lys Ala Thr Phe Ile
500 505 510
Lys Val Pro Gln Asn Gln Asn Gly Lys Ser Lys Gly Tyr Ala Phe Ile
515 520 525
Glu Phe Ala Ser Phe Glu Asp Ala Lys Glu Ala Leu Asn Ser Cys Asn
530 535 540
Lys Arg Glu Ile Glu Gly Arg Ala Ile Arg Leu Glu Leu Gln Gly Pro
545 550 555 560
Arg Gly Ser Pro Asn Ala Arg Ser Gln Pro Ser Lys Thr Leu Phe Val
565 570 575
Lys Gly Leu Ser Glu Asp Thr Thr Glu Glu Thr Leu Lys Glu Ser Phe
580 585 590
Asp Gly Ser Val Arg Ala Arg Ile Val Thr Asp Arg Glu Thr Gly Ser
595 600 605
Ser Lys Gly Phe Gly Phe Val Asp Phe Asn Ser Glu Glu Asp Ala Lys
610 615 620
Ala Ala Lys Glu Ala Met Glu Asp Gly Glu Ile Asp Gly Asn Lys Val
625 630 635 640
Thr Leu Asp Trp Ala Lys Pro Lys Gly Glu Gly Gly Phe Gly Gly Arg
645 650 655
Gly Gly Gly Arg Gly Gly Phe Gly Gly Arg Gly Gly Gly Arg Gly Gly
660 665 670
Arg Gly Gly Phe Gly Gly Arg Gly Arg Gly Gly Phe Gly Gly Arg Gly
675 680 685
Gly Phe Arg Gly Gly Arg Gly Gly Gly Gly Asp His Lys Pro Gln Gly
690 695 700
Lys Lys Thr Lys Phe Glu
705 710
<210> 8
<211> 284
<212> PRT
<213> 智人(Homo sapiens)
<400> 8
Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu
1 5 10 15
Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala
20 25 30
Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys
35 40 45
Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu
50 55 60
Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp
65 70 75 80
Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu
85 90 95
Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys
100 105 110
Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys
115 120 125
Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln
130 135 140
Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg
145 150 155 160
Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu
165 170 175
Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu
180 185 190
Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu
195 200 205
Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu
210 215 220
Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu
225 230 235 240
Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu
245 250 255
Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu
260 265 270
Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile
275 280
<210> 9
<211> 2201
<212> PRT
<213> 智人(Homo sapiens)
<400> 9
Met Gly Ala Met Thr Gln Leu Leu Ala Gly Val Phe Leu Ala Phe Leu
1 5 10 15
Ala Leu Ala Thr Glu Gly Gly Val Leu Lys Lys Val Ile Arg His Lys
20 25 30
Arg Gln Ser Gly Val Asn Ala Thr Leu Pro Glu Glu Asn Gln Pro Val
35 40 45
Val Phe Asn His Val Tyr Asn Ile Lys Leu Pro Val Gly Ser Gln Cys
50 55 60
Ser Val Asp Leu Glu Ser Ala Ser Gly Glu Lys Asp Leu Ala Pro Pro
65 70 75 80
Ser Glu Pro Ser Glu Ser Phe Gln Glu His Thr Val Asp Gly Glu Asn
85 90 95
Gln Ile Val Phe Thr His Arg Ile Asn Ile Pro Arg Arg Ala Cys Gly
100 105 110
Cys Ala Ala Ala Pro Asp Val Lys Glu Leu Leu Ser Arg Leu Glu Glu
115 120 125
Leu Glu Asn Leu Val Ser Ser Leu Arg Glu Gln Cys Thr Ala Gly Ala
130 135 140
Gly Cys Cys Leu Gln Pro Ala Thr Gly Arg Leu Asp Thr Arg Pro Phe
145 150 155 160
Cys Ser Gly Arg Gly Asn Phe Ser Thr Glu Gly Cys Gly Cys Val Cys
165 170 175
Glu Pro Gly Trp Lys Gly Pro Asn Cys Ser Glu Pro Glu Cys Pro Gly
180 185 190
Asn Cys His Leu Arg Gly Arg Cys Ile Asp Gly Gln Cys Ile Cys Asp
195 200 205
Asp Gly Phe Thr Gly Glu Asp Cys Ser Gln Leu Ala Cys Pro Ser Asp
210 215 220
Cys Asn Asp Gln Gly Lys Cys Val Asn Gly Val Cys Ile Cys Phe Glu
225 230 235 240
Gly Tyr Ala Gly Ala Asp Cys Ser Arg Glu Ile Cys Pro Val Pro Cys
245 250 255
Ser Glu Glu His Gly Thr Cys Val Asp Gly Leu Cys Val Cys His Asp
260 265 270
Gly Phe Ala Gly Asp Asp Cys Asn Lys Pro Leu Cys Leu Asn Asn Cys
275 280 285
Tyr Asn Arg Gly Arg Cys Val Glu Asn Glu Cys Val Cys Asp Glu Gly
290 295 300
Phe Thr Gly Glu Asp Cys Ser Glu Leu Ile Cys Pro Asn Asp Cys Phe
305 310 315 320
Asp Arg Gly Arg Cys Ile Asn Gly Thr Cys Tyr Cys Glu Glu Gly Phe
325 330 335
Thr Gly Glu Asp Cys Gly Lys Pro Thr Cys Pro His Ala Cys His Thr
340 345 350
Gln Gly Arg Cys Glu Glu Gly Gln Cys Val Cys Asp Glu Gly Phe Ala
355 360 365
Gly Val Asp Cys Ser Glu Lys Arg Cys Pro Ala Asp Cys His Asn Arg
370 375 380
Gly Arg Cys Val Asp Gly Arg Cys Glu Cys Asp Asp Gly Phe Thr Gly
385 390 395 400
Ala Asp Cys Gly Glu Leu Lys Cys Pro Asn Gly Cys Ser Gly His Gly
405 410 415
Arg Cys Val Asn Gly Gln Cys Val Cys Asp Glu Gly Tyr Thr Gly Glu
420 425 430
Asp Cys Ser Gln Leu Arg Cys Pro Asn Asp Cys His Ser Arg Gly Arg
435 440 445
Cys Val Glu Gly Lys Cys Val Cys Glu Gln Gly Phe Lys Gly Tyr Asp
450 455 460
Cys Ser Asp Met Ser Cys Pro Asn Asp Cys His Gln His Gly Arg Cys
465 470 475 480
Val Asn Gly Met Cys Val Cys Asp Asp Gly Tyr Thr Gly Glu Asp Cys
485 490 495
Arg Asp Arg Gln Cys Pro Arg Asp Cys Ser Asn Arg Gly Leu Cys Val
500 505 510
Asp Gly Gln Cys Val Cys Glu Asp Gly Phe Thr Gly Pro Asp Cys Ala
515 520 525
Glu Leu Ser Cys Pro Asn Asp Cys His Gly Gln Gly Arg Cys Val Asn
530 535 540
Gly Gln Cys Val Cys His Glu Gly Phe Met Gly Lys Asp Cys Lys Glu
545 550 555 560
Gln Arg Cys Pro Ser Asp Cys His Gly Gln Gly Arg Cys Val Asp Gly
565 570 575
Gln Cys Ile Cys His Glu Gly Phe Thr Gly Leu Asp Cys Gly Gln His
580 585 590
Ser Cys Pro Ser Asp Cys Asn Asn Leu Gly Gln Cys Val Ser Gly Arg
595 600 605
Cys Ile Cys Asn Glu Gly Tyr Ser Gly Glu Asp Cys Ser Glu Val Ser
610 615 620
Pro Pro Lys Asp Leu Val Val Thr Glu Val Thr Glu Glu Thr Val Asn
625 630 635 640
Leu Ala Trp Asp Asn Glu Met Arg Val Thr Glu Tyr Leu Val Val Tyr
645 650 655
Thr Pro Thr His Glu Gly Gly Leu Glu Met Gln Phe Arg Val Pro Gly
660 665 670
Asp Gln Thr Ser Thr Ile Ile Gln Glu Leu Glu Pro Gly Val Glu Tyr
675 680 685
Phe Ile Arg Val Phe Ala Ile Leu Glu Asn Lys Lys Ser Ile Pro Val
690 695 700
Ser Ala Arg Val Ala Thr Tyr Leu Pro Ala Pro Glu Gly Leu Lys Phe
705 710 715 720
Lys Ser Ile Lys Glu Thr Ser Val Glu Val Glu Trp Asp Pro Leu Asp
725 730 735
Ile Ala Phe Glu Thr Trp Glu Ile Ile Phe Arg Asn Met Asn Lys Glu
740 745 750
Asp Glu Gly Glu Ile Thr Lys Ser Leu Arg Arg Pro Glu Thr Ser Tyr
755 760 765
Arg Gln Thr Gly Leu Ala Pro Gly Gln Glu Tyr Glu Ile Ser Leu His
770 775 780
Ile Val Lys Asn Asn Thr Arg Gly Pro Gly Leu Lys Arg Val Thr Thr
785 790 795 800
Thr Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp
805 810 815
Thr Thr Ala Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly
820 825 830
Ile Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr
835 840 845
Ile Asp Leu Thr Glu Asp Glu Asn Gln Tyr Ser Ile Gly Asn Leu Lys
850 855 860
Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Arg Arg Gly Asp Met
865 870 875 880
Ser Ser Asn Pro Ala Lys Glu Thr Phe Thr Thr Gly Leu Asp Ala Pro
885 890 895
Arg Asn Leu Arg Arg Val Ser Gln Thr Asp Asn Ser Ile Thr Leu Glu
900 905 910
Trp Arg Asn Gly Lys Ala Ala Ile Asp Ser Tyr Arg Ile Lys Tyr Ala
915 920 925
Pro Ile Ser Gly Gly Asp His Ala Glu Val Asp Val Pro Lys Ser Gln
930 935 940
Gln Ala Thr Thr Lys Thr Thr Leu Thr Gly Leu Arg Pro Gly Thr Glu
945 950 955 960
Tyr Gly Ile Gly Val Ser Ala Val Lys Glu Asp Lys Glu Ser Asn Pro
965 970 975
Ala Thr Ile Asn Ala Ala Thr Glu Leu Asp Thr Pro Lys Asp Leu Gln
980 985 990
Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu Leu Trp Lys Thr Pro
995 1000 1005
Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr Ser Leu Pro Thr
1010 1015 1020
Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr Thr Ser Tyr
1025 1030 1035
Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val Leu Leu
1040 1045 1050
Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val Lys
1055 1060 1065
Ala Ser Thr Glu Gln Ala Pro Glu Leu Glu Asn Leu Thr Val Thr
1070 1075 1080
Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp
1085 1090 1095
Gln Ala Tyr Glu His Phe Ile Ile Gln Val Gln Glu Ala Asn Lys
1100 1105 1110
Val Glu Ala Ala Arg Asn Leu Thr Val Pro Gly Ser Leu Arg Ala
1115 1120 1125
Val Asp Ile Pro Gly Leu Lys Ala Ala Thr Pro Tyr Thr Val Ser
1130 1135 1140
Ile Tyr Gly Val Ile Gln Gly Tyr Arg Thr Pro Val Leu Ser Ala
1145 1150 1155
Glu Ala Ser Thr Gly Glu Thr Pro Asn Leu Gly Glu Val Val Val
1160 1165 1170
Ala Glu Val Gly Trp Asp Ala Leu Lys Leu Asn Trp Thr Ala Pro
1175 1180 1185
Glu Gly Ala Tyr Glu Tyr Phe Phe Ile Gln Val Gln Glu Ala Asp
1190 1195 1200
Thr Val Glu Ala Ala Gln Asn Leu Thr Val Pro Gly Gly Leu Arg
1205 1210 1215
Ser Thr Asp Leu Pro Gly Leu Lys Ala Ala Thr His Tyr Thr Ile
1220 1225 1230
Thr Ile Arg Gly Val Thr Gln Asp Phe Ser Thr Thr Pro Leu Ser
1235 1240 1245
Val Glu Val Leu Thr Glu Glu Val Pro Asp Met Gly Asn Leu Thr
1250 1255 1260
Val Thr Glu Val Ser Trp Asp Ala Leu Arg Leu Asn Trp Thr Thr
1265 1270 1275
Pro Asp Gly Thr Tyr Asp Gln Phe Thr Ile Gln Val Gln Glu Ala
1280 1285 1290
Asp Gln Val Glu Glu Ala His Asn Leu Thr Val Pro Gly Ser Leu
1295 1300 1305
Arg Ser Met Glu Ile Pro Gly Leu Arg Ala Gly Thr Pro Tyr Thr
1310 1315 1320
Val Thr Leu His Gly Glu Val Arg Gly His Ser Thr Arg Pro Leu
1325 1330 1335
Ala Val Glu Val Val Thr Glu Asp Leu Pro Gln Leu Gly Asp Leu
1340 1345 1350
Ala Val Ser Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr
1355 1360 1365
Ala Ala Asp Asn Ala Tyr Glu His Phe Val Ile Gln Val Gln Glu
1370 1375 1380
Val Asn Lys Val Glu Ala Ala Gln Asn Leu Thr Leu Pro Gly Ser
1385 1390 1395
Leu Arg Ala Val Asp Ile Pro Gly Leu Glu Ala Ala Thr Pro Tyr
1400 1405 1410
Arg Val Ser Ile Tyr Gly Val Ile Arg Gly Tyr Arg Thr Pro Val
1415 1420 1425
Leu Ser Ala Glu Ala Ser Thr Ala Lys Glu Pro Glu Ile Gly Asn
1430 1435 1440
Leu Asn Val Ser Asp Ile Thr Pro Glu Ser Phe Asn Leu Ser Trp
1445 1450 1455
Met Ala Thr Asp Gly Ile Phe Glu Thr Phe Thr Ile Glu Ile Ile
1460 1465 1470
Asp Ser Asn Arg Leu Leu Glu Thr Val Glu Tyr Asn Ile Ser Gly
1475 1480 1485
Ala Glu Arg Thr Ala His Ile Ser Gly Leu Pro Pro Ser Thr Asp
1490 1495 1500
Phe Ile Val Tyr Leu Ser Gly Leu Ala Pro Ser Ile Arg Thr Lys
1505 1510 1515
Thr Ile Ser Ala Thr Ala Thr Thr Glu Ala Leu Pro Leu Leu Glu
1520 1525 1530
Asn Leu Thr Ile Ser Asp Ile Asn Pro Tyr Gly Phe Thr Val Ser
1535 1540 1545
Trp Met Ala Ser Glu Asn Ala Phe Asp Ser Phe Leu Val Thr Val
1550 1555 1560
Val Asp Ser Gly Lys Leu Leu Asp Pro Gln Glu Phe Thr Leu Ser
1565 1570 1575
Gly Thr Gln Arg Lys Leu Glu Leu Arg Gly Leu Ile Thr Gly Ile
1580 1585 1590
Gly Tyr Glu Val Met Val Ser Gly Phe Thr Gln Gly His Gln Thr
1595 1600 1605
Lys Pro Leu Arg Ala Glu Ile Val Thr Glu Ala Glu Pro Glu Val
1610 1615 1620
Asp Asn Leu Leu Val Ser Asp Ala Thr Pro Asp Gly Phe Arg Leu
1625 1630 1635
Ser Trp Thr Ala Asp Glu Gly Val Phe Asp Asn Phe Val Leu Lys
1640 1645 1650
Ile Arg Asp Thr Lys Lys Gln Ser Glu Pro Leu Glu Ile Thr Leu
1655 1660 1665
Leu Ala Pro Glu Arg Thr Arg Asp Ile Thr Gly Leu Arg Glu Ala
1670 1675 1680
Thr Glu Tyr Glu Ile Glu Leu Tyr Gly Ile Ser Lys Gly Arg Arg
1685 1690 1695
Ser Gln Thr Val Ser Ala Ile Ala Thr Thr Ala Met Gly Ser Pro
1700 1705 1710
Lys Glu Val Ile Phe Ser Asp Ile Thr Glu Asn Ser Ala Thr Val
1715 1720 1725
Ser Trp Arg Ala Pro Thr Ala Gln Val Glu Ser Phe Arg Ile Thr
1730 1735 1740
Tyr Val Pro Ile Thr Gly Gly Thr Pro Ser Met Val Thr Val Asp
1745 1750 1755
Gly Thr Lys Thr Gln Thr Arg Leu Val Lys Leu Ile Pro Gly Val
1760 1765 1770
Glu Tyr Leu Val Ser Ile Ile Ala Met Lys Gly Phe Glu Glu Ser
1775 1780 1785
Glu Pro Val Ser Gly Ser Phe Thr Thr Ala Leu Asp Gly Pro Ser
1790 1795 1800
Gly Leu Val Thr Ala Asn Ile Thr Asp Ser Glu Ala Leu Ala Arg
1805 1810 1815
Trp Gln Pro Ala Ile Ala Thr Val Asp Ser Tyr Val Ile Ser Tyr
1820 1825 1830
Thr Gly Glu Lys Val Pro Glu Ile Thr Arg Thr Val Ser Gly Asn
1835 1840 1845
Thr Val Glu Tyr Ala Leu Thr Asp Leu Glu Pro Ala Thr Glu Tyr
1850 1855 1860
Thr Leu Arg Ile Phe Ala Glu Lys Gly Pro Gln Lys Ser Ser Thr
1865 1870 1875
Ile Thr Ala Lys Phe Thr Thr Asp Leu Asp Ser Pro Arg Asp Leu
1880 1885 1890
Thr Ala Thr Glu Val Gln Ser Glu Thr Ala Leu Leu Thr Trp Arg
1895 1900 1905
Pro Pro Arg Ala Ser Val Thr Gly Tyr Leu Leu Val Tyr Glu Ser
1910 1915 1920
Val Asp Gly Thr Val Lys Glu Val Ile Val Gly Pro Asp Thr Thr
1925 1930 1935
Ser Tyr Ser Leu Ala Asp Leu Ser Pro Ser Thr His Tyr Thr Ala
1940 1945 1950
Lys Ile Gln Ala Leu Asn Gly Pro Leu Arg Ser Asn Met Ile Gln
1955 1960 1965
Thr Ile Phe Thr Thr Ile Gly Leu Leu Tyr Pro Phe Pro Lys Asp
1970 1975 1980
Cys Ser Gln Ala Met Leu Asn Gly Asp Thr Thr Ser Gly Leu Tyr
1985 1990 1995
Thr Ile Tyr Leu Asn Gly Asp Lys Ala Glu Ala Leu Glu Val Phe
2000 2005 2010
Cys Asp Met Thr Ser Asp Gly Gly Gly Trp Ile Val Phe Leu Arg
2015 2020 2025
Arg Lys Asn Gly Arg Glu Asn Phe Tyr Gln Asn Trp Lys Ala Tyr
2030 2035 2040
Ala Ala Gly Phe Gly Asp Arg Arg Glu Glu Phe Trp Leu Gly Leu
2045 2050 2055
Asp Asn Leu Asn Lys Ile Thr Ala Gln Gly Gln Tyr Glu Leu Arg
2060 2065 2070
Val Asp Leu Arg Asp His Gly Glu Thr Ala Phe Ala Val Tyr Asp
2075 2080 2085
Lys Phe Ser Val Gly Asp Ala Lys Thr Arg Tyr Lys Leu Lys Val
2090 2095 2100
Glu Gly Tyr Ser Gly Thr Ala Gly Asp Ser Met Ala Tyr His Asn
2105 2110 2115
Gly Arg Ser Phe Ser Thr Phe Asp Lys Asp Thr Asp Ser Ala Ile
2120 2125 2130
Thr Asn Cys Ala Leu Ser Tyr Lys Gly Ala Phe Trp Tyr Arg Asn
2135 2140 2145
Cys His Arg Val Asn Leu Met Gly Arg Tyr Gly Asp Asn Asn His
2150 2155 2160
Ser Gln Gly Val Asn Trp Phe His Trp Lys Gly His Glu His Ser
2165 2170 2175
Ile Gln Phe Ala Glu Met Lys Leu Arg Pro Ser Asn Phe Arg Asn
2180 2185 2190
Leu Glu Gly Arg Arg Lys Arg Ala
2195 2200
<210> 10
<211> 291
<212> PRT
<213> 智人(Homo sapiens)
<400> 10
Met Gln Arg Ala Arg Pro Thr Leu Trp Ala Ala Ala Leu Thr Leu Leu
1 5 10 15
Val Leu Leu Arg Gly Pro Pro Val Ala Arg Ala Gly Ala Ser Ser Ala
20 25 30
Gly Leu Gly Pro Val Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Leu
35 40 45
Ala Gln Cys Ala Pro Pro Pro Ala Val Cys Ala Glu Leu Val Arg Glu
50 55 60
Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Ser Glu Gly Gln Pro
65 70 75 80
Cys Gly Ile Tyr Thr Glu Arg Cys Gly Ser Gly Leu Arg Cys Gln Pro
85 90 95
Ser Pro Asp Glu Ala Arg Pro Leu Gln Ala Leu Leu Asp Gly Arg Gly
100 105 110
Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu Arg Ala Tyr Leu Leu
115 120 125
Pro Ala Pro Pro Ala Pro Gly Asn Ala Ser Glu Ser Glu Glu Asp Arg
130 135 140
Ser Ala Gly Ser Val Glu Ser Pro Ser Val Ser Ser Thr His Arg Val
145 150 155 160
Ser Asp Pro Lys Phe His Pro Leu His Ser Lys Ile Ile Ile Ile Lys
165 170 175
Lys Gly His Ala Lys Asp Ser Gln Arg Tyr Lys Val Asp Tyr Glu Ser
180 185 190
Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu Ser Lys Arg Glu Thr
195 200 205
Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp Thr Leu Asn His Leu
210 215 220
Lys Phe Leu Asn Val Leu Ser Pro Arg Gly Val His Ile Pro Asn Cys
225 230 235 240
Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln Cys Arg Pro Ser Lys Gly
245 250 255
Arg Lys Arg Gly Phe Cys Trp Cys Val Asp Lys Tyr Gly Gln Pro Leu
260 265 270
Pro Gly Tyr Thr Thr Lys Gly Lys Glu Asp Val His Cys Tyr Ser Met
275 280 285
Gln Ser Lys
290
<210> 11
<211> 1838
<212> PRT
<213> 智人(Homo sapiens)
<400> 11
Met Asp Val His Thr Arg Trp Lys Ala Arg Ser Ala Leu Arg Pro Gly
1 5 10 15
Ala Pro Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Trp Ala Pro Pro
20 25 30
Pro Ser Arg Ala Ala Gln Pro Ala Asp Leu Leu Lys Val Leu Asp Phe
35 40 45
His Asn Leu Pro Asp Gly Ile Thr Lys Thr Thr Gly Phe Cys Ala Thr
50 55 60
Arg Arg Ser Ser Lys Gly Pro Asp Val Ala Tyr Arg Val Thr Lys Asp
65 70 75 80
Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu Tyr Pro Ala Ser Ala Phe
85 90 95
Pro Glu Asp Phe Ser Ile Leu Thr Thr Val Lys Ala Lys Lys Gly Ser
100 105 110
Gln Ala Phe Leu Val Ser Ile Tyr Asn Glu Gln Gly Ile Gln Gln Ile
115 120 125
Gly Leu Glu Leu Gly Arg Ser Pro Val Phe Leu Tyr Glu Asp His Thr
130 135 140
Gly Lys Pro Gly Pro Glu Asp Tyr Pro Leu Phe Arg Gly Ile Asn Leu
145 150 155 160
Ser Asp Gly Lys Trp His Arg Ile Ala Leu Ser Val His Lys Lys Asn
165 170 175
Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr Thr Lys Phe Leu Asp
180 185 190
Arg Ser Asp His Pro Met Ile Asp Ile Asn Gly Ile Ile Val Phe Gly
195 200 205
Thr Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Leu
210 215 220
Leu Phe Val Ser Asp His Arg Ala Ala Tyr Asp Tyr Cys Glu His Tyr
225 230 235 240
Ser Pro Asp Cys Asp Thr Ala Val Pro Asp Thr Pro Gln Ser Gln Asp
245 250 255
Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly Asp Gly Glu Gly Glu Thr
260 265 270
Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp Pro Glu Asp Leu Gly Lys
275 280 285
Glu Pro Thr Pro Ser Lys Lys Pro Val Glu Ala Ala Lys Glu Thr Thr
290 295 300
Glu Val Pro Glu Glu Leu Thr Pro Thr Pro Thr Glu Ala Ala Pro Met
305 310 315 320
Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu Glu Asp Val Gly Ile Gly
325 330 335
Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr Tyr Thr Pro Ser Pro Tyr
340 345 350
Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu Asn Pro Asp Gln Pro Thr
355 360 365
Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr Ser Thr Ala Asp Thr Ser
370 375 380
Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly Glu Gly Ala Asp Asp Leu
385 390 395 400
Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg Asn Leu Asp Glu Asn Tyr
405 410 415
Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser Pro Ser Glu Ile Gly Pro
420 425 430
Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr Glu Gly Ile Gly Gly Pro
435 440 445
Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Ile Ile Glu Pro Gly
450 455 460
Met Leu Ile Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Pro
465 470 475 480
Gly Pro Pro Gly Thr Met Gly Pro Thr Gly Gln Val Gly Asp Pro Gly
485 490 495
Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu
500 505 510
Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Phe Gly Gly
515 520 525
Gly Gly Asp Ala Gly Ser Lys Gly Pro Met Val Ser Ala Gln Glu Ser
530 535 540
Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro
545 550 555 560
Ala Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Pro Pro
565 570 575
Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly Asp Val Gly Pro Gln Gly
580 585 590
Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Lys Pro Gly Arg
595 600 605
Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg Gly Met Pro Gly Gln Thr
610 615 620
Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Ala Gly Leu Pro Gly
625 630 635 640
Glu Lys Gly His Arg Gly Asp Pro Gly Pro Ser Gly Pro Pro Gly Pro
645 650 655
Pro Gly Asp Asp Gly Glu Arg Gly Asp Asp Gly Glu Val Gly Pro Arg
660 665 670
Gly Leu Pro Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly
675 680 685
Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Thr Gly Met Asp Gly Gln
690 695 700
Pro Gly Pro Lys Gly Asn Val Gly Pro Gln Gly Glu Pro Gly Pro Pro
705 710 715 720
Gly Gln Gln Gly Asn Pro Gly Ala Gln Gly Leu Pro Gly Pro Gln Gly
725 730 735
Ala Ile Gly Pro Pro Gly Glu Lys Gly Pro Leu Gly Lys Pro Gly Leu
740 745 750
Pro Gly Met Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu
755 760 765
Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln Gly
770 775 780
Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Ile
785 790 795 800
Arg Gly Leu Lys Gly Thr Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro
805 810 815
Gly Phe Lys Gly Asp Met Gly Ile Lys Gly Asp Arg Gly Glu Ile Gly
820 825 830
Pro Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg
835 840 845
Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys
850 855 860
Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly
865 870 875 880
Pro Lys Gly Ser Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu
885 890 895
Lys Gly Gly Arg Gly Thr Pro Gly Lys Pro Gly Pro Arg Gly Gln Arg
900 905 910
Gly Pro Thr Gly Pro Arg Gly Glu Arg Gly Pro Arg Gly Ile Thr Gly
915 920 925
Lys Pro Gly Pro Lys Gly Asn Ser Gly Gly Asp Gly Pro Ala Gly Pro
930 935 940
Pro Gly Glu Arg Gly Pro Asn Gly Pro Gln Gly Pro Thr Gly Phe Pro
945 950 955 960
Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly
965 970 975
His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro
980 985 990
Pro Gly Pro Pro Gly Val Val Gly Pro Gln Gly Pro Thr Gly Glu Thr
995 1000 1005
Gly Pro Met Gly Glu Arg Gly His Pro Gly Pro Pro Gly Pro Pro
1010 1015 1020
Gly Glu Gln Gly Leu Pro Gly Leu Ala Gly Lys Glu Gly Thr Lys
1025 1030 1035
Gly Asp Pro Gly Pro Ala Gly Leu Pro Gly Lys Asp Gly Pro Pro
1040 1045 1050
Gly Leu Arg Gly Phe Pro Gly Asp Arg Gly Leu Pro Gly Pro Val
1055 1060 1065
Gly Ala Leu Gly Leu Lys Gly Asn Glu Gly Pro Pro Gly Pro Pro
1070 1075 1080
Gly Pro Ala Gly Ser Pro Gly Glu Arg Gly Pro Ala Gly Ala Ala
1085 1090 1095
Gly Pro Ile Gly Ile Pro Gly Arg Pro Gly Pro Gln Gly Pro Pro
1100 1105 1110
Gly Pro Ala Gly Glu Lys Gly Ala Pro Gly Glu Lys Gly Pro Gln
1115 1120 1125
Gly Pro Ala Gly Arg Asp Gly Leu Gln Gly Pro Val Gly Leu Pro
1130 1135 1140
Gly Pro Ala Gly Pro Val Gly Pro Pro Gly Glu Asp Gly Asp Lys
1145 1150 1155
Gly Glu Ile Gly Glu Pro Gly Gln Lys Gly Ser Lys Gly Asp Lys
1160 1165 1170
Gly Glu Gln Gly Pro Pro Gly Pro Thr Gly Pro Gln Gly Pro Ile
1175 1180 1185
Gly Gln Pro Gly Pro Ser Gly Ala Asp Gly Glu Pro Gly Pro Arg
1190 1195 1200
Gly Gln Gln Gly Leu Phe Gly Gln Lys Gly Asp Glu Gly Pro Arg
1205 1210 1215
Gly Phe Pro Gly Pro Pro Gly Pro Val Gly Leu Gln Gly Leu Pro
1220 1225 1230
Gly Pro Pro Gly Glu Lys Gly Glu Thr Gly Asp Val Gly Gln Met
1235 1240 1245
Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Ser Gly Ala Pro
1250 1255 1260
Gly Ala Asp Gly Pro Gln Gly Pro Pro Gly Gly Ile Gly Asn Pro
1265 1270 1275
Gly Ala Val Gly Glu Lys Gly Glu Pro Gly Glu Ala Gly Glu Pro
1280 1285 1290
Gly Leu Pro Gly Glu Gly Gly Pro Pro Gly Pro Lys Gly Glu Arg
1295 1300 1305
Gly Glu Lys Gly Glu Ser Gly Pro Ser Gly Ala Ala Gly Pro Pro
1310 1315 1320
Gly Pro Lys Gly Pro Pro Gly Asp Asp Gly Pro Lys Gly Ser Pro
1325 1330 1335
Gly Pro Val Gly Phe Pro Gly Asp Pro Gly Pro Pro Gly Glu Pro
1340 1345 1350
Gly Pro Ala Gly Gln Asp Gly Pro Pro Gly Asp Lys Gly Asp Asp
1355 1360 1365
Gly Glu Pro Gly Gln Thr Gly Ser Pro Gly Pro Thr Gly Glu Pro
1370 1375 1380
Gly Pro Ser Gly Pro Pro Gly Lys Arg Gly Pro Pro Gly Pro Ala
1385 1390 1395
Gly Pro Glu Gly Arg Gln Gly Glu Lys Gly Ala Lys Gly Glu Ala
1400 1405 1410
Gly Leu Glu Gly Pro Pro Gly Lys Thr Gly Pro Ile Gly Pro Gln
1415 1420 1425
Gly Ala Pro Gly Lys Pro Gly Pro Asp Gly Leu Arg Gly Ile Pro
1430 1435 1440
Gly Pro Val Gly Glu Gln Gly Leu Pro Gly Ser Pro Gly Pro Asp
1445 1450 1455
Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Leu Pro Gly Leu Lys
1460 1465 1470
Gly Asp Ser Gly Pro Lys Gly Glu Lys Gly His Pro Gly Leu Ile
1475 1480 1485
Gly Leu Ile Gly Pro Pro Gly Glu Gln Gly Glu Lys Gly Asp Arg
1490 1495 1500
Gly Leu Pro Gly Pro Gln Gly Ser Ser Gly Pro Lys Gly Glu Gln
1505 1510 1515
Gly Ile Thr Gly Pro Ser Gly Pro Ile Gly Pro Pro Gly Pro Pro
1520 1525 1530
Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Ala Lys Gly Ser Ser
1535 1540 1545
Gly Pro Thr Gly Pro Lys Gly Glu Ala Gly His Pro Gly Pro Pro
1550 1555 1560
Gly Pro Pro Gly Pro Pro Gly Glu Val Ile Gln Pro Leu Pro Ile
1565 1570 1575
Gln Ala Ser Arg Thr Arg Arg Asn Ile Asp Ala Ser Gln Leu Leu
1580 1585 1590
Asp Asp Gly Asn Gly Glu Asn Tyr Val Asp Tyr Ala Asp Gly Met
1595 1600 1605
Glu Glu Ile Phe Gly Ser Leu Asn Ser Leu Lys Leu Glu Ile Glu
1610 1615 1620
Gln Met Lys Arg Pro Leu Gly Thr Gln Gln Asn Pro Ala Arg Thr
1625 1630 1635
Cys Lys Asp Leu Gln Leu Cys His Pro Asp Phe Pro Asp Gly Glu
1640 1645 1650
Tyr Trp Val Asp Pro Asn Gln Gly Cys Ser Arg Asp Ser Phe Lys
1655 1660 1665
Val Tyr Cys Asn Phe Thr Ala Gly Gly Ser Thr Cys Val Phe Pro
1670 1675 1680
Asp Lys Lys Ser Glu Gly Ala Arg Ile Thr Ser Trp Pro Lys Glu
1685 1690 1695
Asn Pro Gly Ser Trp Phe Ser Glu Phe Lys Arg Gly Lys Leu Leu
1700 1705 1710
Ser Tyr Val Asp Ala Glu Gly Asn Pro Val Gly Val Val Gln Met
1715 1720 1725
Thr Phe Leu Arg Leu Leu Ser Ala Ser Ala His Gln Asn Val Thr
1730 1735 1740
Tyr His Cys Tyr Gln Ser Val Ala Trp Gln Asp Ala Ala Thr Gly
1745 1750 1755
Ser Tyr Asp Lys Ala Leu Arg Phe Leu Gly Ser Asn Asp Glu Glu
1760 1765 1770
Met Ser Tyr Asp Asn Asn Pro Tyr Ile Arg Ala Leu Val Asp Gly
1775 1780 1785
Cys Ala Thr Lys Lys Gly Tyr Gln Lys Thr Val Leu Glu Ile Asp
1790 1795 1800
Thr Pro Lys Val Glu Gln Val Pro Ile Val Asp Ile Met Phe Asn
1805 1810 1815
Asp Phe Gly Glu Ala Ser Gln Lys Phe Gly Phe Glu Val Gly Pro
1820 1825 1830
Ala Cys Phe Met Gly
1835
<210> 12
<211> 323
<212> PRT
<213> 智人(Homo sapiens)
<400> 12
Met Gln Ala Ala Trp Leu Leu Gly Ala Leu Val Val Pro Gln Leu Leu
1 5 10 15
Gly Phe Gly His Gly Ala Arg Gly Ala Glu Arg Glu Trp Glu Gly Gly
20 25 30
Trp Gly Gly Ala Gln Glu Glu Glu Arg Glu Arg Glu Ala Leu Met Leu
35 40 45
Lys His Leu Gln Glu Ala Leu Gly Leu Pro Ala Gly Arg Gly Asp Glu
50 55 60
Asn Pro Ala Gly Thr Val Glu Gly Lys Glu Asp Trp Glu Met Glu Glu
65 70 75 80
Asp Gln Gly Glu Glu Glu Glu Glu Glu Ala Thr Pro Thr Pro Ser Ser
85 90 95
Gly Pro Ser Pro Ser Pro Thr Pro Glu Asp Ile Val Thr Tyr Ile Leu
100 105 110
Gly Arg Leu Ala Gly Leu Asp Ala Gly Leu His Gln Leu His Val Arg
115 120 125
Leu His Ala Leu Asp Thr Arg Val Val Glu Leu Thr Gln Gly Leu Arg
130 135 140
Gln Leu Arg Asn Ala Ala Gly Asp Thr Arg Asp Ala Val Gln Ala Leu
145 150 155 160
Gln Glu Ala Gln Gly Arg Ala Glu Arg Glu His Gly Arg Leu Glu Gly
165 170 175
Cys Leu Lys Gly Leu Arg Leu Gly His Lys Cys Phe Leu Leu Ser Arg
180 185 190
Asp Phe Glu Ala Gln Ala Ala Ala Gln Ala Arg Cys Thr Ala Arg Gly
195 200 205
Gly Ser Leu Ala Gln Pro Ala Asp Arg Gln Gln Met Glu Ala Leu Thr
210 215 220
Arg Tyr Leu Arg Ala Ala Leu Ala Pro Tyr Asn Trp Pro Val Trp Leu
225 230 235 240
Gly Val His Asp Arg Arg Ala Glu Gly Leu Tyr Leu Phe Glu Asn Gly
245 250 255
Gln Arg Val Ser Phe Phe Ala Trp His Arg Ser Pro Arg Pro Glu Leu
260 265 270
Gly Ala Gln Pro Ser Ala Ser Pro His Pro Leu Ser Pro Asp Gln Pro
275 280 285
Asn Gly Gly Thr Leu Glu Asn Cys Val Ala Gln Ala Ser Asp Asp Gly
290 295 300
Ser Trp Trp Asp His Asp Cys Gln Arg Arg Leu Tyr Tyr Val Cys Glu
305 310 315 320
Phe Pro Phe
<210> 13
<211> 2468
<212> PRT
<213> 智人(Homo sapiens)
<400> 13
Met Ala Thr Val Val Val Glu Ala Thr Glu Pro Glu Pro Ser Gly Ser
1 5 10 15
Ile Ala Asn Pro Ala Ala Ser Thr Ser Pro Ser Leu Ser His Arg Phe
20 25 30
Leu Asp Ser Lys Phe Tyr Leu Leu Val Val Val Gly Glu Ile Val Thr
35 40 45
Glu Glu His Leu Arg Arg Ala Ile Gly Asn Ile Glu Leu Gly Ile Arg
50 55 60
Ser Trp Asp Thr Asn Leu Ile Glu Cys Asn Leu Asp Gln Glu Leu Lys
65 70 75 80
Leu Phe Val Ser Arg His Ser Ala Arg Phe Ser Pro Glu Val Pro Gly
85 90 95
Gln Lys Ile Leu His His Arg Ser Asp Val Leu Glu Thr Val Val Leu
100 105 110
Ile Asn Pro Ser Asp Glu Ala Val Ser Thr Glu Val Arg Leu Met Ile
115 120 125
Thr Asp Ala Ala Arg His Lys Leu Leu Val Leu Thr Gly Gln Cys Phe
130 135 140
Glu Asn Thr Gly Glu Leu Ile Leu Gln Ser Gly Ser Phe Ser Phe Gln
145 150 155 160
Asn Phe Ile Glu Ile Phe Thr Asp Gln Glu Ile Gly Glu Leu Leu Ser
165 170 175
Thr Thr His Pro Ala Asn Lys Ala Ser Leu Thr Leu Phe Cys Pro Glu
180 185 190
Glu Gly Asp Trp Lys Asn Ser Asn Leu Asp Arg His Asn Leu Gln Asp
195 200 205
Phe Ile Asn Ile Lys Leu Asn Ser Ala Ser Ile Leu Pro Glu Met Glu
210 215 220
Gly Leu Ser Glu Phe Thr Glu Tyr Leu Ser Glu Ser Val Glu Val Pro
225 230 235 240
Ser Pro Phe Asp Ile Leu Glu Pro Pro Thr Ser Gly Gly Phe Leu Lys
245 250 255
Leu Ser Lys Pro Cys Cys Tyr Ile Phe Pro Gly Gly Arg Gly Asp Ser
260 265 270
Ala Leu Phe Ala Val Asn Gly Phe Asn Met Leu Ile Asn Gly Gly Ser
275 280 285
Glu Arg Lys Ser Cys Phe Trp Lys Leu Ile Arg His Leu Asp Arg Val
290 295 300
Asp Ser Ile Leu Leu Thr His Ile Gly Asp Asp Asn Leu Pro Gly Ile
305 310 315 320
Asn Ser Met Leu Gln Arg Lys Ile Ala Glu Leu Glu Glu Glu Gln Ser
325 330 335
Gln Gly Ser Thr Thr Asn Ser Asp Trp Met Lys Asn Leu Ile Ser Pro
340 345 350
Asp Leu Gly Val Val Phe Leu Asn Val Pro Glu Asn Leu Lys Asn Pro
355 360 365
Glu Pro Asn Ile Lys Met Lys Arg Ser Ile Glu Glu Ala Cys Phe Thr
370 375 380
Leu Gln Tyr Leu Asn Lys Leu Ser Met Lys Pro Glu Pro Leu Phe Arg
385 390 395 400
Ser Val Gly Asn Thr Ile Asp Pro Val Ile Leu Phe Gln Lys Met Gly
405 410 415
Val Gly Lys Leu Glu Met Tyr Val Leu Asn Pro Val Lys Ser Ser Lys
420 425 430
Glu Met Gln Tyr Phe Met Gln Gln Trp Thr Gly Thr Asn Lys Asp Lys
435 440 445
Ala Glu Phe Ile Leu Pro Asn Gly Gln Glu Val Asp Leu Pro Ile Ser
450 455 460
Tyr Leu Thr Ser Val Ser Ser Leu Ile Val Trp His Pro Ala Asn Pro
465 470 475 480
Ala Glu Lys Ile Ile Arg Val Leu Phe Pro Gly Asn Ser Thr Gln Tyr
485 490 495
Asn Ile Leu Glu Gly Leu Glu Lys Leu Lys His Leu Asp Phe Leu Lys
500 505 510
Gln Pro Leu Ala Thr Gln Lys Asp Leu Thr Gly Gln Val Pro Thr Pro
515 520 525
Val Val Lys Gln Thr Lys Leu Lys Gln Arg Ala Asp Ser Arg Glu Ser
530 535 540
Leu Lys Pro Ala Ala Lys Pro Leu Pro Ser Lys Ser Val Arg Lys Glu
545 550 555 560
Ser Lys Glu Glu Thr Pro Glu Val Thr Lys Val Asn His Val Glu Lys
565 570 575
Pro Pro Lys Val Glu Ser Lys Glu Lys Val Met Val Lys Lys Asp Lys
580 585 590
Pro Ile Lys Thr Glu Thr Lys Pro Ser Val Thr Glu Lys Glu Val Pro
595 600 605
Ser Lys Glu Glu Pro Ser Pro Val Lys Ala Glu Val Ala Glu Lys Gln
610 615 620
Ala Thr Asp Val Lys Pro Lys Ala Ala Lys Glu Lys Thr Val Lys Lys
625 630 635 640
Glu Thr Lys Val Lys Pro Glu Asp Lys Lys Glu Glu Lys Glu Lys Pro
645 650 655
Lys Lys Glu Val Ala Lys Lys Glu Asp Lys Thr Pro Ile Lys Lys Glu
660 665 670
Glu Lys Pro Lys Lys Glu Glu Val Lys Lys Glu Val Lys Lys Glu Ile
675 680 685
Lys Lys Glu Glu Lys Lys Glu Pro Lys Lys Glu Val Lys Lys Glu Thr
690 695 700
Pro Pro Lys Glu Val Lys Lys Glu Val Lys Lys Glu Glu Lys Lys Glu
705 710 715 720
Val Lys Lys Glu Glu Lys Glu Pro Lys Lys Glu Ile Lys Lys Leu Pro
725 730 735
Lys Asp Ala Lys Lys Ser Ser Thr Pro Leu Ser Glu Ala Lys Lys Pro
740 745 750
Ala Ala Leu Lys Pro Lys Val Pro Lys Lys Glu Glu Ser Val Lys Lys
755 760 765
Asp Ser Val Ala Ala Gly Lys Pro Lys Glu Lys Gly Lys Ile Lys Val
770 775 780
Ile Lys Lys Glu Gly Lys Ala Ala Glu Ala Val Ala Ala Ala Val Gly
785 790 795 800
Thr Gly Ala Thr Thr Ala Ala Val Met Ala Ala Ala Gly Ile Ala Ala
805 810 815
Ile Gly Pro Ala Lys Glu Leu Glu Ala Glu Arg Ser Leu Met Ser Ser
820 825 830
Pro Glu Asp Leu Thr Lys Asp Phe Glu Glu Leu Lys Ala Glu Glu Val
835 840 845
Asp Val Thr Lys Asp Ile Lys Pro Gln Leu Glu Leu Ile Glu Asp Glu
850 855 860
Glu Lys Leu Lys Glu Thr Glu Pro Val Glu Ala Tyr Val Ile Gln Lys
865 870 875 880
Glu Arg Glu Val Thr Lys Gly Pro Ala Glu Ser Pro Asp Glu Gly Ile
885 890 895
Thr Thr Thr Glu Gly Glu Gly Glu Cys Glu Gln Thr Pro Glu Glu Leu
900 905 910
Glu Pro Val Glu Lys Gln Gly Val Asp Asp Ile Glu Lys Phe Glu Asp
915 920 925
Glu Gly Ala Gly Phe Glu Glu Ser Ser Glu Thr Gly Asp Tyr Glu Glu
930 935 940
Lys Ala Glu Thr Glu Glu Ala Glu Glu Pro Glu Glu Asp Gly Glu Glu
945 950 955 960
His Val Cys Val Ser Ala Ser Lys His Ser Pro Thr Glu Asp Glu Glu
965 970 975
Ser Ala Lys Ala Glu Ala Asp Ala Tyr Ile Arg Glu Lys Arg Glu Ser
980 985 990
Val Ala Ser Gly Asp Asp Arg Ala Glu Glu Asp Met Asp Glu Ala Ile
995 1000 1005
Glu Lys Gly Glu Ala Glu Gln Ser Glu Glu Glu Ala Asp Glu Glu
1010 1015 1020
Asp Lys Ala Glu Asp Ala Arg Glu Glu Glu Tyr Glu Pro Glu Lys
1025 1030 1035
Met Glu Ala Glu Asp Tyr Val Met Ala Val Val Asp Lys Ala Ala
1040 1045 1050
Glu Ala Gly Gly Ala Glu Glu Gln Tyr Gly Phe Leu Thr Thr Pro
1055 1060 1065
Thr Lys Gln Leu Gly Ala Gln Ser Pro Gly Arg Glu Pro Ala Ser
1070 1075 1080
Ser Ile His Asp Glu Thr Leu Pro Gly Gly Ser Glu Ser Glu Ala
1085 1090 1095
Thr Ala Ser Asp Glu Glu Asn Arg Glu Asp Gln Pro Glu Glu Phe
1100 1105 1110
Thr Ala Thr Ser Gly Tyr Thr Gln Ser Thr Ile Glu Ile Ser Ser
1115 1120 1125
Glu Pro Thr Pro Met Asp Glu Met Ser Thr Pro Arg Asp Val Met
1130 1135 1140
Ser Asp Glu Thr Asn Asn Glu Glu Thr Glu Ser Pro Ser Gln Glu
1145 1150 1155
Phe Val Asn Ile Thr Lys Tyr Glu Ser Ser Leu Tyr Ser Gln Glu
1160 1165 1170
Tyr Ser Lys Pro Ala Asp Val Thr Pro Leu Asn Gly Phe Ser Glu
1175 1180 1185
Gly Ser Lys Thr Asp Ala Thr Asp Gly Lys Asp Tyr Asn Ala Ser
1190 1195 1200
Ala Ser Thr Ile Ser Pro Pro Ser Ser Met Glu Glu Asp Lys Phe
1205 1210 1215
Ser Arg Ser Ala Leu Arg Asp Ala Tyr Cys Ser Glu Val Lys Ala
1220 1225 1230
Ser Thr Thr Leu Asp Ile Lys Asp Ser Ile Ser Ala Val Ser Ser
1235 1240 1245
Glu Lys Val Ser Pro Ser Lys Ser Pro Ser Leu Ser Pro Ser Pro
1250 1255 1260
Pro Ser Pro Leu Glu Lys Thr Pro Leu Gly Glu Arg Ser Val Asn
1265 1270 1275
Phe Ser Leu Thr Pro Asn Glu Ile Lys Val Ser Ala Glu Ala Glu
1280 1285 1290
Val Ala Pro Val Ser Pro Glu Val Thr Gln Glu Val Val Glu Glu
1295 1300 1305
His Cys Ala Ser Pro Glu Asp Lys Thr Leu Glu Val Val Ser Pro
1310 1315 1320
Ser Gln Ser Val Thr Gly Ser Ala Gly His Thr Pro Tyr Tyr Gln
1325 1330 1335
Ser Pro Thr Asp Glu Lys Ser Ser His Leu Pro Thr Glu Val Ile
1340 1345 1350
Glu Lys Pro Pro Ala Val Pro Val Ser Phe Glu Phe Ser Asp Ala
1355 1360 1365
Lys Asp Glu Asn Glu Arg Ala Ser Val Ser Pro Met Asp Glu Pro
1370 1375 1380
Val Pro Asp Ser Glu Ser Pro Ile Glu Lys Val Leu Ser Pro Leu
1385 1390 1395
Arg Ser Pro Pro Leu Ile Gly Ser Glu Ser Ala Tyr Glu Ser Phe
1400 1405 1410
Leu Ser Ala Asp Asp Lys Ala Ser Gly Arg Gly Ala Glu Ser Pro
1415 1420 1425
Phe Glu Glu Lys Ser Gly Lys Gln Gly Ser Pro Asp Gln Val Ser
1430 1435 1440
Pro Val Ser Glu Met Thr Ser Thr Ser Leu Tyr Gln Asp Lys Gln
1445 1450 1455
Glu Gly Lys Ser Thr Asp Phe Ala Pro Ile Lys Glu Asp Phe Gly
1460 1465 1470
Gln Glu Lys Lys Thr Asp Asp Val Glu Ala Met Ser Ser Gln Pro
1475 1480 1485
Ala Leu Ala Leu Asp Glu Arg Lys Leu Gly Asp Val Ser Pro Thr
1490 1495 1500
Gln Ile Asp Val Ser Gln Phe Gly Ser Phe Lys Glu Asp Thr Lys
1505 1510 1515
Met Ser Ile Ser Glu Gly Thr Val Ser Asp Lys Ser Ala Thr Pro
1520 1525 1530
Val Asp Glu Gly Val Ala Glu Asp Thr Tyr Ser His Met Glu Gly
1535 1540 1545
Val Ala Ser Val Ser Thr Ala Ser Val Ala Thr Ser Ser Phe Pro
1550 1555 1560
Glu Pro Thr Thr Asp Asp Val Ser Pro Ser Leu His Ala Glu Val
1565 1570 1575
Gly Ser Pro His Ser Thr Glu Val Asp Asp Ser Leu Ser Val Ser
1580 1585 1590
Val Val Gln Thr Pro Thr Thr Phe Gln Glu Thr Glu Met Ser Pro
1595 1600 1605
Ser Lys Glu Glu Cys Pro Arg Pro Met Ser Ile Ser Pro Pro Asp
1610 1615 1620
Phe Ser Pro Lys Thr Ala Lys Ser Arg Thr Pro Val Gln Asp His
1625 1630 1635
Arg Ser Glu Gln Ser Ser Met Ser Ile Glu Phe Gly Gln Glu Ser
1640 1645 1650
Pro Glu Gln Ser Leu Ala Met Asp Phe Ser Arg Gln Ser Pro Asp
1655 1660 1665
His Pro Thr Val Gly Ala Gly Val Leu His Ile Thr Glu Asn Gly
1670 1675 1680
Pro Thr Glu Val Asp Tyr Ser Pro Ser Asp Met Gln Asp Ser Ser
1685 1690 1695
Leu Ser His Lys Ile Pro Pro Met Glu Glu Pro Ser Tyr Thr Gln
1700 1705 1710
Asp Asn Asp Leu Ser Glu Leu Ile Ser Val Ser Gln Val Glu Ala
1715 1720 1725
Ser Pro Ser Thr Ser Ser Ala His Thr Pro Ser Gln Ile Ala Ser
1730 1735 1740
Pro Leu Gln Glu Asp Thr Leu Ser Asp Val Ala Pro Pro Arg Asp
1745 1750 1755
Met Ser Leu Tyr Ala Ser Leu Thr Ser Glu Lys Val Gln Ser Leu
1760 1765 1770
Glu Gly Glu Lys Leu Ser Pro Lys Ser Asp Ile Ser Pro Leu Thr
1775 1780 1785
Pro Arg Glu Ser Ser Pro Leu Tyr Ser Pro Thr Phe Ser Asp Ser
1790 1795 1800
Thr Ser Ala Val Lys Glu Lys Thr Ala Thr Cys His Ser Ser Ser
1805 1810 1815
Ser Pro Pro Ile Asp Ala Ala Ser Ala Glu Pro Tyr Gly Phe Arg
1820 1825 1830
Ala Ser Val Leu Phe Asp Thr Met Gln His His Leu Ala Leu Asn
1835 1840 1845
Arg Asp Leu Ser Thr Pro Gly Leu Glu Lys Asp Ser Gly Gly Lys
1850 1855 1860
Thr Pro Gly Asp Phe Ser Tyr Ala Tyr Gln Lys Pro Glu Glu Thr
1865 1870 1875
Thr Arg Ser Pro Asp Glu Glu Asp Tyr Asp Tyr Glu Ser Tyr Glu
1880 1885 1890
Lys Thr Thr Arg Thr Ser Asp Val Gly Gly Tyr Tyr Tyr Glu Lys
1895 1900 1905
Ile Glu Arg Thr Thr Lys Ser Pro Ser Asp Ser Gly Tyr Ser Tyr
1910 1915 1920
Glu Thr Ile Gly Lys Thr Thr Lys Thr Pro Glu Asp Gly Asp Tyr
1925 1930 1935
Ser Tyr Glu Ile Ile Glu Lys Thr Thr Arg Thr Pro Glu Glu Gly
1940 1945 1950
Gly Tyr Ser Tyr Asp Ile Ser Glu Lys Thr Thr Ser Pro Pro Glu
1955 1960 1965
Val Ser Gly Tyr Ser Tyr Glu Lys Thr Glu Arg Ser Arg Arg Leu
1970 1975 1980
Leu Asp Asp Ile Ser Asn Gly Tyr Asp Asp Ser Glu Asp Gly Gly
1985 1990 1995
His Thr Leu Gly Asp Pro Ser Tyr Ser Tyr Glu Thr Thr Glu Lys
2000 2005 2010
Ile Thr Ser Phe Pro Glu Ser Glu Gly Tyr Ser Tyr Glu Thr Ser
2015 2020 2025
Thr Lys Thr Thr Arg Thr Pro Asp Thr Ser Thr Tyr Cys Tyr Glu
2030 2035 2040
Thr Ala Glu Lys Ile Thr Arg Thr Pro Gln Ala Ser Thr Tyr Ser
2045 2050 2055
Tyr Glu Thr Ser Asp Leu Cys Tyr Thr Ala Glu Lys Lys Ser Pro
2060 2065 2070
Ser Glu Ala Arg Gln Asp Val Asp Leu Cys Leu Val Ser Ser Cys
2075 2080 2085
Glu Tyr Lys His Pro Lys Thr Glu Leu Ser Pro Ser Phe Ile Asn
2090 2095 2100
Pro Asn Pro Leu Glu Trp Phe Ala Ser Glu Glu Pro Thr Glu Glu
2105 2110 2115
Ser Glu Lys Pro Leu Thr Gln Ser Gly Gly Ala Pro Pro Pro Pro
2120 2125 2130
Gly Gly Lys Gln Gln Gly Arg Gln Cys Asp Glu Thr Pro Pro Thr
2135 2140 2145
Ser Val Ser Glu Ser Ala Pro Ser Gln Thr Asp Ser Asp Val Pro
2150 2155 2160
Pro Glu Thr Glu Glu Cys Pro Ser Ile Thr Ala Asp Ala Asn Ile
2165 2170 2175
Asp Ser Glu Asp Glu Ser Glu Thr Ile Pro Thr Asp Lys Thr Val
2180 2185 2190
Thr Tyr Lys His Met Asp Pro Pro Pro Ala Pro Val Gln Asp Arg
2195 2200 2205
Ser Pro Ser Pro Arg His Pro Asp Val Ser Met Val Asp Pro Glu
2210 2215 2220
Ala Leu Ala Ile Glu Gln Asn Leu Gly Lys Ala Leu Lys Lys Asp
2225 2230 2235
Leu Lys Glu Lys Thr Lys Thr Lys Lys Pro Gly Thr Lys Thr Lys
2240 2245 2250
Ser Ser Ser Pro Val Lys Lys Ser Asp Gly Lys Ser Lys Pro Leu
2255 2260 2265
Ala Ala Ser Pro Lys Pro Ala Gly Leu Lys Glu Ser Ser Asp Lys
2270 2275 2280
Val Ser Arg Val Ala Ser Pro Lys Lys Lys Glu Ser Val Glu Lys
2285 2290 2295
Ala Ala Lys Pro Thr Thr Thr Pro Glu Val Lys Ala Ala Arg Gly
2300 2305 2310
Glu Glu Lys Asp Lys Glu Thr Lys Asn Ala Ala Asn Ala Ser Ala
2315 2320 2325
Ser Lys Ser Ala Lys Thr Ala Thr Ala Gly Pro Gly Thr Thr Lys
2330 2335 2340
Thr Thr Lys Ser Ser Ala Val Pro Pro Gly Leu Pro Val Tyr Leu
2345 2350 2355
Asp Leu Cys Tyr Ile Pro Asn His Ser Asn Ser Lys Asn Val Asp
2360 2365 2370
Val Glu Phe Phe Lys Arg Val Arg Ser Ser Tyr Tyr Val Val Ser
2375 2380 2385
Gly Asn Asp Pro Ala Ala Glu Glu Pro Ser Arg Ala Val Leu Asp
2390 2395 2400
Ala Leu Leu Glu Gly Lys Ala Gln Trp Gly Ser Asn Met Gln Val
2405 2410 2415
Thr Leu Ile Pro Thr His Asp Ser Glu Val Met Arg Glu Trp Tyr
2420 2425 2430
Gln Glu Thr His Glu Lys Gln Gln Asp Leu Asn Ile Met Val Leu
2435 2440 2445
Ala Ser Ser Ser Thr Val Val Met Gln Asp Glu Ser Phe Pro Ala
2450 2455 2460
Cys Lys Ile Glu Leu
2465
<210> 14
<211> 215
<212> PRT
<213> 智人(Homo sapiens)
<400> 14
Met Pro Gly Glu Ala Thr Glu Thr Val Pro Ala Thr Glu Gln Glu Leu
1 5 10 15
Pro Gln Pro Gln Ala Glu Thr Gly Ser Gly Thr Glu Ser Asp Ser Asp
20 25 30
Glu Ser Val Pro Glu Leu Glu Glu Gln Asp Ser Thr Gln Ala Thr Thr
35 40 45
Gln Gln Ala Gln Leu Ala Ala Ala Ala Glu Ile Asp Glu Glu Pro Val
50 55 60
Ser Lys Ala Lys Gln Ser Arg Ser Glu Lys Lys Ala Arg Lys Ala Met
65 70 75 80
Ser Lys Leu Gly Leu Arg Gln Val Thr Gly Val Thr Arg Val Thr Ile
85 90 95
Arg Lys Ser Lys Asn Ile Leu Phe Val Ile Thr Lys Pro Asp Val Tyr
100 105 110
Lys Ser Pro Ala Ser Asp Thr Tyr Ile Val Phe Gly Glu Ala Lys Ile
115 120 125
Glu Asp Leu Ser Gln Gln Ala Gln Leu Ala Ala Ala Glu Lys Phe Lys
130 135 140
Val Gln Gly Glu Ala Val Ser Asn Ile Gln Glu Asn Thr Gln Thr Pro
145 150 155 160
Thr Val Gln Glu Glu Ser Glu Glu Glu Glu Val Asp Glu Thr Gly Val
165 170 175
Glu Val Lys Asp Ile Glu Leu Val Met Ser Gln Ala Asn Val Ser Arg
180 185 190
Ala Lys Ala Val Arg Ala Leu Lys Asn Asn Ser Asn Asp Ile Val Asn
195 200 205
Ala Ile Met Glu Leu Thr Met
210 215
<210> 15
<211> 234
<212> PRT
<213> 智人(Homo sapiens)
<400> 15
Met Ala Glu Arg Gly Tyr Ser Phe Ser Leu Thr Thr Phe Ser Pro Ser
1 5 10 15
Gly Lys Leu Val Gln Ile Glu Tyr Ala Leu Ala Ala Val Ala Gly Gly
20 25 30
Ala Pro Ser Val Gly Ile Lys Ala Ala Asn Gly Val Val Leu Ala Thr
35 40 45
Glu Lys Lys Gln Lys Ser Ile Leu Tyr Asp Glu Arg Ser Val His Lys
50 55 60
Val Glu Pro Ile Thr Lys His Ile Gly Leu Val Tyr Ser Gly Met Gly
65 70 75 80
Pro Asp Tyr Arg Val Leu Val His Arg Ala Arg Lys Leu Ala Gln Gln
85 90 95
Tyr Tyr Leu Val Tyr Gln Glu Pro Ile Pro Thr Ala Gln Leu Val Gln
100 105 110
Arg Val Ala Ser Val Met Gln Glu Tyr Thr Gln Ser Gly Gly Val Arg
115 120 125
Pro Phe Gly Val Ser Leu Leu Ile Cys Gly Trp Asn Glu Gly Arg Pro
130 135 140
Tyr Leu Phe Gln Ser Asp Pro Ser Gly Ala Tyr Phe Ala Trp Lys Ala
145 150 155 160
Thr Ala Met Gly Lys Asn Tyr Val Asn Gly Lys Thr Phe Leu Glu Lys
165 170 175
Arg Tyr Asn Glu Asp Leu Glu Leu Glu Asp Ala Ile His Thr Ala Ile
180 185 190
Leu Thr Leu Lys Glu Ser Phe Glu Gly Gln Met Thr Glu Asp Asn Ile
195 200 205
Glu Val Gly Ile Cys Asn Glu Ala Gly Phe Arg Arg Leu Thr Pro Thr
210 215 220
Glu Val Lys Asp Tyr Leu Ala Ala Ile Ala
225 230
<210> 16
<211> 297
<212> PRT
<213> 智人(Homo sapiens)
<400> 16
Met Gly Phe Val Lys Val Val Lys Asn Lys Ala Tyr Phe Lys Arg Tyr
1 5 10 15
Gln Val Lys Phe Arg Arg Arg Arg Glu Gly Lys Thr Asp Tyr Tyr Ala
20 25 30
Arg Lys Arg Leu Val Ile Gln Asp Lys Asn Lys Tyr Asn Thr Pro Lys
35 40 45
Tyr Arg Met Ile Val Arg Val Thr Asn Arg Asp Ile Ile Cys Gln Ile
50 55 60
Ala Tyr Ala Arg Ile Glu Gly Asp Met Ile Val Cys Ala Ala Tyr Ala
65 70 75 80
His Glu Leu Pro Lys Tyr Gly Val Lys Val Gly Leu Thr Asn Tyr Ala
85 90 95
Ala Ala Tyr Cys Thr Gly Leu Leu Leu Ala Arg Arg Leu Leu Asn Arg
100 105 110
Phe Gly Met Asp Lys Ile Tyr Glu Gly Gln Val Glu Val Thr Gly Asp
115 120 125
Glu Tyr Asn Val Glu Ser Ile Asp Gly Gln Pro Gly Ala Phe Thr Cys
130 135 140
Tyr Leu Asp Ala Gly Leu Ala Arg Thr Thr Thr Gly Asn Lys Val Phe
145 150 155 160
Gly Ala Leu Lys Gly Ala Val Asp Gly Gly Leu Ser Ile Pro His Ser
165 170 175
Thr Lys Arg Phe Pro Gly Tyr Asp Ser Glu Ser Lys Glu Phe Asn Ala
180 185 190
Glu Val His Arg Lys His Ile Met Gly Gln Asn Val Ala Asp Tyr Met
195 200 205
Arg Tyr Leu Met Glu Glu Asp Glu Asp Ala Tyr Lys Lys Gln Phe Ser
210 215 220
Gln Tyr Ile Lys Asn Ser Val Thr Pro Asp Met Met Glu Glu Met Tyr
225 230 235 240
Lys Lys Ala His Ala Ala Ile Arg Glu Asn Pro Val Tyr Glu Lys Lys
245 250 255
Pro Lys Lys Glu Val Lys Lys Lys Arg Trp Asn Arg Pro Lys Met Ser
260 265 270
Leu Ala Gln Lys Lys Asp Arg Val Ala Gln Lys Lys Ala Ser Phe Leu
275 280 285
Arg Ala Gln Glu Arg Ala Ala Glu Ser
290 295
<210> 17
<211> 151
<212> PRT
<213> 智人(Homo sapiens)
<400> 17
Met Cys Asp Phe Thr Glu Asp Gln Thr Ala Glu Phe Lys Glu Ala Phe
1 5 10 15
Gln Leu Phe Asp Arg Thr Gly Asp Gly Lys Ile Leu Tyr Ser Gln Cys
20 25 30
Gly Asp Val Met Arg Ala Leu Gly Gln Asn Pro Thr Asn Ala Glu Val
35 40 45
Leu Lys Val Leu Gly Asn Pro Lys Ser Asp Glu Met Asn Val Lys Val
50 55 60
Leu Asp Phe Glu His Phe Leu Pro Met Leu Gln Thr Val Ala Lys Asn
65 70 75 80
Lys Asp Gln Gly Thr Tyr Glu Asp Tyr Val Glu Gly Leu Arg Val Phe
85 90 95
Asp Lys Glu Gly Asn Gly Thr Val Met Gly Ala Glu Ile Arg His Val
100 105 110
Leu Val Thr Leu Gly Glu Lys Met Thr Glu Glu Glu Val Glu Met Leu
115 120 125
Val Ala Gly His Glu Asp Ser Asn Gly Cys Ile Asn Tyr Glu Ala Phe
130 135 140
Val Arg His Ile Leu Ser Gly
145 150
<210> 18
<211> 339
<212> PRT
<213> 智人(Homo sapiens)
<400> 18
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn
1 5 10 15
Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn
20 25 30
Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr
35 40 45
Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly
50 55 60
Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu
65 70 75 80
Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile
85 90 95
Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly
100 105 110
Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His
115 120 125
Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser
130 135 140
Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn
145 150 155 160
Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His
165 170 175
Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn
180 185 190
Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser
195 200 205
Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His
210 215 220
Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met
225 230 235 240
Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr
245 250 255
Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly
260 265 270
Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu
275 280 285
Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp
290 295 300
Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly
305 310 315 320
Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp
325 330 335
Glu Lys Ile
<210> 19
<211> 573
<212> PRT
<213> 智人(Homo sapiens)
<400> 19
Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg
1 5 10 15
Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe
20 25 30
Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala
35 40 45
Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile
50 55 60
Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val
65 70 75 80
Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys
85 90 95
Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly
100 105 110
Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe
115 120 125
Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val
130 135 140
Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys
145 150 155 160
Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala
165 170 175
Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys
180 185 190
Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn
195 200 205
Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile
210 215 220
Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln
225 230 235 240
Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser
245 250 255
Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val
260 265 270
Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu
275 280 285
Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly
290 295 300
Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr
305 310 315 320
Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp
325 330 335
Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys
340 345 350
Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu
355 360 365
Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu
370 375 380
Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly
385 390 395 400
Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu
405 410 415
Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val
420 425 430
Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile
435 440 445
Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly
450 455 460
Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala
465 470 475 480
Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln
485 490 495
Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn
500 505 510
Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala
515 520 525
Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val
530 535 540
Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala
545 550 555 560
Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe
565 570
<210> 20
<211> 390
<212> PRT
<213> 智人(Homo sapiens)
<400> 20
Met Glu Asp Pro Thr Leu Tyr Ile Val Glu Arg Pro Leu Pro Gly Tyr
1 5 10 15
Pro Asp Ala Glu Ala Pro Glu Pro Ser Ser Ala Gly Ala Gln Ala Ala
20 25 30
Glu Glu Pro Ser Gly Ala Gly Ser Glu Glu Leu Ile Lys Ser Asp Gln
35 40 45
Val Asn Gly Val Leu Val Leu Ser Leu Leu Asp Lys Ile Ile Gly Ala
50 55 60
Val Asp Gln Ile Gln Leu Thr Gln Ala Gln Leu Glu Glu Arg Gln Ala
65 70 75 80
Glu Met Glu Gly Ala Val Gln Ser Ile Gln Gly Glu Leu Ser Lys Leu
85 90 95
Gly Lys Ala His Ala Thr Thr Ser Asn Thr Val Ser Lys Leu Leu Glu
100 105 110
Lys Val Arg Lys Val Ser Val Asn Val Lys Thr Val Arg Gly Ser Leu
115 120 125
Glu Arg Gln Ala Gly Gln Ile Lys Lys Leu Glu Val Asn Glu Ala Glu
130 135 140
Leu Leu Arg Arg Arg Asn Phe Lys Val Met Ile Tyr Gln Asp Glu Val
145 150 155 160
Lys Leu Pro Ala Lys Leu Ser Ile Ser Lys Ser Leu Lys Glu Ser Glu
165 170 175
Ala Leu Pro Glu Lys Glu Gly Glu Glu Leu Gly Glu Gly Glu Arg Pro
180 185 190
Glu Glu Asp Ala Ala Ala Leu Glu Leu Ser Ser Asp Glu Ala Val Glu
195 200 205
Val Glu Glu Val Ile Glu Glu Ser Arg Ala Glu Arg Ile Lys Arg Ser
210 215 220
Gly Leu Arg Arg Val Asp Asp Phe Lys Lys Ala Phe Ser Lys Glu Lys
225 230 235 240
Met Glu Lys Thr Lys Val Arg Thr Arg Glu Asn Leu Glu Lys Thr Arg
245 250 255
Leu Lys Thr Lys Glu Asn Leu Glu Lys Thr Arg His Thr Leu Glu Lys
260 265 270
Arg Met Asn Lys Leu Gly Thr Arg Leu Val Pro Ala Glu Arg Arg Glu
275 280 285
Lys Leu Lys Thr Ser Arg Asp Lys Leu Arg Lys Ser Phe Thr Pro Asp
290 295 300
His Val Val Tyr Ala Arg Ser Lys Thr Ala Val Tyr Lys Val Pro Pro
305 310 315 320
Phe Thr Phe His Val Lys Lys Ile Arg Glu Gly Gln Val Glu Val Leu
325 330 335
Lys Ala Thr Glu Met Val Glu Val Gly Ala Asp Asp Asp Glu Gly Gly
340 345 350
Ala Glu Arg Gly Glu Ala Gly Asp Leu Arg Arg Gly Ser Ser Pro Asp
355 360 365
Val His Ala Leu Leu Glu Ile Thr Glu Glu Ser Asp Ala Val Leu Val
370 375 380
Asp Lys Ser Asp Ser Asp
385 390
<210> 21
<211> 461
<212> PRT
<213> 智人(Homo sapiens)
<400> 21
Met Pro Pro Ser Gly Pro Arg Gly Thr Leu Leu Leu Leu Pro Leu Leu
1 5 10 15
Leu Leu Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly
20 25 30
Ala Pro Asn Lys Glu Glu Thr Pro Ala Thr Glu Ser Pro Asp Thr Gly
35 40 45
Leu Tyr Tyr His Arg Tyr Leu Gln Glu Val Ile Asp Val Leu Glu Thr
50 55 60
Asp Gly His Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile
65 70 75 80
Lys Ser Gly Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val
85 90 95
Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Ser Arg Leu Arg
100 105 110
Met Leu Leu Lys Ala Lys Met Asp Ala Glu Gln Asp Pro Asn Val Gln
115 120 125
Val Asp His Leu Asn Leu Leu Lys Gln Phe Glu His Leu Asp Pro Gln
130 135 140
Asn Gln His Thr Phe Glu Ala Arg Asp Leu Glu Leu Leu Ile Gln Thr
145 150 155 160
Ala Thr Arg Asp Leu Ala Gln Tyr Asp Ala Ala His His Glu Glu Phe
165 170 175
Lys Arg Tyr Glu Met Leu Lys Glu His Glu Arg Arg Arg Tyr Leu Glu
180 185 190
Ser Leu Gly Glu Glu Gln Arg Lys Glu Ala Glu Arg Lys Leu Glu Glu
195 200 205
Gln Gln Arg Arg His Arg Glu His Pro Lys Val Asn Val Pro Gly Ser
210 215 220
Gln Ala Gln Leu Lys Glu Val Trp Glu Glu Leu Asp Gly Leu Asp Pro
225 230 235 240
Asn Arg Phe Asn Pro Lys Thr Phe Phe Ile Leu His Asp Ile Asn Ser
245 250 255
Asp Gly Val Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys Glu
260 265 270
Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Arg Glu
275 280 285
Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Lys Asn Val
290 295 300
Asp Thr Asn Gln Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Ala Ser
305 310 315 320
Thr Gln Arg Lys Glu Phe Gly Asp Thr Gly Glu Gly Trp Glu Thr Val
325 330 335
Glu Met His Pro Ala Tyr Thr Glu Glu Glu Leu Arg Arg Phe Glu Glu
340 345 350
Glu Leu Ala Ala Arg Glu Ala Glu Leu Asn Ala Lys Ala Gln Arg Leu
355 360 365
Ser Gln Glu Thr Glu Ala Leu Gly Arg Ser Gln Gly Arg Leu Glu Ala
370 375 380
Gln Lys Arg Glu Leu Gln Gln Ala Val Leu His Met Glu Gln Arg Lys
385 390 395 400
Gln Gln Gln Gln Gln Gln Gln Gly His Lys Ala Pro Ala Ala His Pro
405 410 415
Glu Gly Gln Leu Lys Phe His Pro Asp Thr Asp Asp Val Pro Val Pro
420 425 430
Ala Pro Ala Gly Asp Gln Lys Glu Val Asp Thr Ser Glu Lys Lys Leu
435 440 445
Leu Glu Arg Leu Pro Glu Val Glu Val Pro Gln His Leu
450 455 460
<210> 22
<211> 645
<212> PRT
<213> 智人(Homo sapiens)
<400> 22
Met Arg Pro Arg Lys Ala Phe Leu Leu Leu Leu Leu Leu Gly Leu Val
1 5 10 15
Gln Leu Leu Ala Val Ala Gly Ala Glu Gly Pro Asp Glu Asp Ser Ser
20 25 30
Asn Arg Glu Asn Ala Ile Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp
35 40 45
Asp Asp Glu Glu Glu Asp Asp Leu Glu Val Lys Glu Glu Asn Gly Val
50 55 60
Leu Val Leu Asn Asp Ala Asn Phe Asp Asn Phe Val Ala Asp Lys Asp
65 70 75 80
Thr Val Leu Leu Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln
85 90 95
Phe Ala Pro Glu Tyr Glu Lys Ile Ala Asn Ile Leu Lys Asp Lys Asp
100 105 110
Pro Pro Ile Pro Val Ala Lys Ile Asp Ala Thr Ser Ala Ser Val Leu
115 120 125
Ala Ser Arg Phe Asp Val Ser Gly Tyr Pro Thr Ile Lys Ile Leu Lys
130 135 140
Lys Gly Gln Ala Val Asp Tyr Glu Gly Ser Arg Thr Gln Glu Glu Ile
145 150 155 160
Val Ala Lys Val Arg Glu Val Ser Gln Pro Asp Trp Thr Pro Pro Pro
165 170 175
Glu Val Thr Leu Val Leu Thr Lys Glu Asn Phe Asp Glu Val Val Asn
180 185 190
Asp Ala Asp Ile Ile Leu Val Glu Phe Tyr Ala Pro Trp Cys Gly His
195 200 205
Cys Lys Lys Leu Ala Pro Glu Tyr Glu Lys Ala Ala Lys Glu Leu Ser
210 215 220
Lys Arg Ser Pro Pro Ile Pro Leu Ala Lys Val Asp Ala Thr Ala Glu
225 230 235 240
Thr Asp Leu Ala Lys Arg Phe Asp Val Ser Gly Tyr Pro Thr Leu Lys
245 250 255
Ile Phe Arg Lys Gly Arg Pro Tyr Asp Tyr Asn Gly Pro Arg Glu Lys
260 265 270
Tyr Gly Ile Val Asp Tyr Met Ile Glu Gln Ser Gly Pro Pro Ser Lys
275 280 285
Glu Ile Leu Thr Leu Lys Gln Val Gln Glu Phe Leu Lys Asp Gly Asp
290 295 300
Asp Val Ile Ile Ile Gly Val Phe Lys Gly Glu Ser Asp Pro Ala Tyr
305 310 315 320
Gln Gln Tyr Gln Asp Ala Ala Asn Asn Leu Arg Glu Asp Tyr Lys Phe
325 330 335
His His Thr Phe Ser Thr Glu Ile Ala Lys Phe Leu Lys Val Ser Gln
340 345 350
Gly Gln Leu Val Val Met Gln Pro Glu Lys Phe Gln Ser Lys Tyr Glu
355 360 365
Pro Arg Ser His Met Met Asp Val Gln Gly Ser Thr Gln Asp Ser Ala
370 375 380
Ile Lys Asp Phe Val Leu Lys Tyr Ala Leu Pro Leu Val Gly His Arg
385 390 395 400
Lys Val Ser Asn Asp Ala Lys Arg Tyr Thr Arg Arg Pro Leu Val Val
405 410 415
Val Tyr Tyr Ser Val Asp Phe Ser Phe Asp Tyr Arg Ala Ala Thr Gln
420 425 430
Phe Trp Arg Ser Lys Val Leu Glu Val Ala Lys Asp Phe Pro Glu Tyr
435 440 445
Thr Phe Ala Ile Ala Asp Glu Glu Asp Tyr Ala Gly Glu Val Lys Asp
450 455 460
Leu Gly Leu Ser Glu Ser Gly Glu Asp Val Asn Ala Ala Ile Leu Asp
465 470 475 480
Glu Ser Gly Lys Lys Phe Ala Met Glu Pro Glu Glu Phe Asp Ser Asp
485 490 495
Thr Leu Arg Glu Phe Val Thr Ala Phe Lys Lys Gly Lys Leu Lys Pro
500 505 510
Val Ile Lys Ser Gln Pro Val Pro Lys Asn Asn Lys Gly Pro Val Lys
515 520 525
Val Val Val Gly Lys Thr Phe Asp Ser Ile Val Met Asp Pro Lys Lys
530 535 540
Asp Val Leu Ile Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln
545 550 555 560
Leu Glu Pro Val Tyr Asn Ser Leu Ala Lys Lys Tyr Lys Gly Gln Lys
565 570 575
Gly Leu Val Ile Ala Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser
580 585 590
Asp Arg Tyr Lys Val Glu Gly Phe Pro Thr Ile Tyr Phe Ala Pro Ser
595 600 605
Gly Asp Lys Lys Asn Pro Val Lys Phe Glu Gly Gly Asp Arg Asp Leu
610 615 620
Glu His Leu Ser Lys Phe Ile Glu Glu His Ala Thr Lys Leu Ser Arg
625 630 635 640
Thr Lys Glu Glu Leu
645
<210> 23
<211> 508
<212> PRT
<213> 智人(Homo sapiens)
<400> 23
Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg
1 5 10 15
Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser
20 25 30
Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe
35 40 45
Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala
50 55 60
Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala
65 70 75 80
Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val
85 90 95
Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser
100 105 110
Pro Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp
115 120 125
Leu Lys Lys Arg Thr Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala
130 135 140
Ala Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe
145 150 155 160
Phe Lys Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala
165 170 175
Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val
180 185 190
Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe Lys Lys
195 200 205
Phe Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn
210 215 220
Leu Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe
225 230 235 240
Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His
245 250 255
Ile Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu
260 265 270
Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile Leu Phe
275 280 285
Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe
290 295 300
Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg Leu Ile Thr Leu
305 310 315 320
Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala
325 330 335
Glu Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys
340 345 350
Pro His Leu Met Ser Gln Glu Leu Pro Glu Asp Trp Asp Lys Gln Pro
355 360 365
Val Lys Val Leu Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu
370 375 380
Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys
385 390 395 400
Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp
405 410 415
His Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val
420 425 430
Glu Ala Val Lys Val His Ser Phe Pro Thr Leu Lys Phe Phe Pro Ala
435 440 445
Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp
450 455 460
Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala Gly Asp
465 470 475 480
Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu
485 490 495
Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu Leu
500 505
<210> 24
<211> 911
<212> PRT
<213> 智人(Homo sapiens)
<400> 24
Met Val Asp Tyr His Ala Ala Asn Gln Ser Tyr Gln Tyr Gly Pro Ser
1 5 10 15
Ser Ala Gly Asn Gly Ala Gly Gly Gly Gly Ser Met Gly Asp Tyr Met
20 25 30
Ala Gln Glu Asp Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp
35 40 45
Glu Lys Gln Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu
50 55 60
Arg Lys Ala Gly Thr Gln Ile Glu Asn Ile Asp Glu Asp Phe Arg Asp
65 70 75 80
Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu
85 90 95
Pro Lys Pro Glu Arg Gly Lys Met Arg Val His Lys Ile Asn Asn Val
100 105 110
Asn Lys Ala Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser
115 120 125
Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Ala Lys Met Thr Leu Gly
130 135 140
Met Ile Trp Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val
145 150 155 160
Glu Glu Thr Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys
165 170 175
Thr Ala Pro Tyr Lys Asn Val Asn Val Gln Asn Phe His Ile Ser Trp
180 185 190
Lys Asp Gly Leu Ala Phe Asn Ala Leu Ile His Arg His Arg Pro Glu
195 200 205
Leu Ile Glu Tyr Asp Lys Leu Arg Lys Asp Asp Pro Val Thr Asn Leu
210 215 220
Asn Asn Ala Phe Glu Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met
225 230 235 240
Leu Asp Ala Glu Asp Ile Val Asn Thr Ala Arg Pro Asp Glu Lys Ala
245 250 255
Ile Met Thr Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln
260 265 270
Lys Ala Glu Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn
275 280 285
Gln Glu Asn Glu His Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp
290 295 300
Leu Leu Glu Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asp Arg Val
305 310 315 320
Pro Gln Lys Thr Ile Gln Glu Met Gln Gln Lys Leu Glu Asp Phe Arg
325 330 335
Asp Tyr Arg Arg Val His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln
340 345 350
Leu Glu Ile Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn
355 360 365
Arg Pro Ala Phe Met Pro Ser Glu Gly Lys Met Val Ser Asp Ile Asn
370 375 380
Asn Gly Trp Gln His Leu Glu Gln Ala Glu Lys Gly Tyr Glu Glu Trp
385 390 395 400
Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu Asp His Leu Ala Glu
405 410 415
Lys Phe Arg Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys
420 425 430
Glu Ala Met Leu Lys His Arg Asp Tyr Glu Thr Ala Thr Leu Ser Asp
435 440 445
Ile Lys Ala Leu Ile Arg Lys His Glu Ala Phe Glu Ser Asp Leu Ala
450 455 460
Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu
465 470 475 480
Asn Glu Leu Asp Tyr Tyr Asp Ser His Asn Val Asn Thr Arg Cys Gln
485 490 495
Lys Ile Cys Asp Gln Trp Asp Ala Leu Gly Ser Leu Thr His Ser Arg
500 505 510
Arg Glu Ala Leu Glu Lys Thr Glu Lys Gln Leu Glu Ala Ile Asp Gln
515 520 525
Leu His Leu Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met
530 535 540
Glu Ser Ala Met Glu Asp Leu Gln Asp Met Phe Ile Val His Thr Ile
545 550 555 560
Glu Glu Ile Glu Gly Leu Ile Ser Ala His Asp Gln Phe Lys Ser Thr
565 570 575
Leu Pro Asp Ala Asp Arg Glu Arg Glu Ala Ile Leu Ala Ile His Lys
580 585 590
Glu Ala Gln Arg Ile Ala Glu Ser Asn His Ile Lys Leu Ser Gly Ser
595 600 605
Asn Pro Tyr Thr Thr Val Thr Pro Gln Ile Ile Asn Ser Lys Trp Glu
610 615 620
Lys Val Gln Gln Leu Val Pro Lys Arg Asp His Ala Leu Leu Glu Glu
625 630 635 640
Gln Ser Lys Gln Gln Ser Asn Glu His Leu Arg Arg Gln Phe Ala Ser
645 650 655
Gln Ala Asn Val Val Gly Pro Trp Ile Gln Thr Lys Met Glu Glu Ile
660 665 670
Gly Arg Ile Ser Ile Glu Met Asn Gly Thr Leu Glu Asp Gln Leu Ser
675 680 685
His Leu Lys Gln Tyr Glu Arg Ser Ile Val Asp Tyr Lys Pro Asn Leu
690 695 700
Asp Leu Leu Glu Gln Gln His Gln Leu Ile Gln Glu Ala Leu Ile Phe
705 710 715 720
Asp Asn Lys His Thr Asn Tyr Thr Met Glu His Ile Arg Val Gly Trp
725 730 735
Glu Gln Leu Leu Thr Thr Ile Ala Arg Thr Ile Asn Glu Val Glu Asn
740 745 750
Gln Ile Leu Thr Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Gln
755 760 765
Glu Phe Arg Ala Ser Phe Asn His Phe Asp Lys Asp His Gly Gly Ala
770 775 780
Leu Gly Pro Glu Glu Phe Lys Ala Cys Leu Ile Ser Leu Gly Tyr Asp
785 790 795 800
Val Glu Asn Asp Arg Gln Gly Glu Ala Glu Phe Asn Arg Ile Met Ser
805 810 815
Leu Val Asp Pro Asn His Ser Gly Leu Val Thr Phe Gln Ala Phe Ile
820 825 830
Asp Phe Met Ser Arg Glu Thr Thr Asp Thr Asp Thr Ala Asp Gln Val
835 840 845
Ile Ala Ser Phe Lys Val Leu Ala Gly Asp Lys Asn Phe Ile Thr Ala
850 855 860
Glu Glu Leu Arg Arg Glu Leu Pro Pro Asp Gln Ala Glu Tyr Cys Ile
865 870 875 880
Ala Arg Met Ala Pro Tyr Gln Gly Pro Asp Ala Val Pro Gly Ala Leu
885 890 895
Asp Tyr Lys Ser Phe Ser Thr Ala Leu Tyr Gly Glu Ser Asp Leu
900 905 910
<210> 25
<211> 281
<212> PRT
<213> 智人(Homo sapiens)
<400> 25
Met Ala Thr Asn Phe Leu Ala His Glu Lys Ile Trp Phe Asp Lys Phe
1 5 10 15
Lys Tyr Asp Asp Ala Glu Arg Arg Phe Tyr Glu Gln Met Asn Gly Pro
20 25 30
Val Ala Gly Ala Ser Arg Gln Glu Asn Gly Ala Ser Val Ile Leu Arg
35 40 45
Asp Ile Ala Arg Ala Arg Glu Asn Ile Gln Lys Ser Leu Ala Gly Ser
50 55 60
Ser Gly Pro Gly Ala Ser Ser Gly Thr Ser Gly Asp His Gly Glu Leu
65 70 75 80
Val Val Arg Ile Ala Ser Leu Glu Val Glu Asn Gln Ser Leu Arg Gly
85 90 95
Val Val Gln Glu Leu Gln Gln Ala Ile Ser Lys Leu Glu Ala Arg Leu
100 105 110
Asn Val Leu Glu Lys Ser Ser Pro Gly His Arg Ala Thr Ala Pro Gln
115 120 125
Thr Gln His Val Ser Pro Met Arg Gln Val Glu Pro Pro Ala Lys Lys
130 135 140
Pro Ala Thr Pro Ala Glu Asp Asp Glu Asp Asp Asp Ile Asp Leu Phe
145 150 155 160
Gly Ser Asp Asn Glu Glu Glu Asp Lys Glu Ala Ala Gln Leu Arg Glu
165 170 175
Glu Arg Leu Arg Gln Tyr Ala Glu Lys Lys Ala Lys Lys Pro Ala Leu
180 185 190
Val Ala Lys Ser Ser Ile Leu Leu Asp Val Lys Pro Trp Asp Asp Glu
195 200 205
Thr Asp Met Ala Gln Leu Glu Ala Cys Val Arg Ser Ile Gln Leu Asp
210 215 220
Gly Leu Val Trp Gly Ala Ser Lys Leu Val Pro Val Gly Tyr Gly Ile
225 230 235 240
Arg Lys Leu Gln Ile Gln Cys Val Val Glu Asp Asp Lys Val Gly Thr
245 250 255
Asp Leu Leu Glu Glu Glu Ile Thr Lys Phe Glu Glu His Val Gln Ser
260 265 270
Val Asp Ile Ala Ala Phe Asn Lys Ile
275 280
<210> 26
<211> 286
<212> PRT
<213> 智人(Homo sapiens)
<400> 26
Met Ala Glu Asp Gly Glu Glu Ala Glu Phe His Phe Ala Ala Leu Tyr
1 5 10 15
Ile Ser Gly Gln Trp Pro Arg Leu Arg Ala Asp Thr Asp Leu Gln Arg
20 25 30
Leu Gly Ser Ser Ala Met Ala Pro Ser Arg Lys Phe Phe Val Gly Gly
35 40 45
Asn Trp Lys Met Asn Gly Arg Lys Gln Ser Leu Gly Glu Leu Ile Gly
50 55 60
Thr Leu Asn Ala Ala Lys Val Pro Ala Asp Thr Glu Val Val Cys Ala
65 70 75 80
Pro Pro Thr Ala Tyr Ile Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys
85 90 95
Ile Ala Val Ala Ala Gln Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe
100 105 110
Thr Gly Glu Ile Ser Pro Gly Met Ile Lys Asp Cys Gly Ala Thr Trp
115 120 125
Val Val Leu Gly His Ser Glu Arg Arg His Val Phe Gly Glu Ser Asp
130 135 140
Glu Leu Ile Gly Gln Lys Val Ala His Ala Leu Ala Glu Gly Leu Gly
145 150 155 160
Val Ile Ala Cys Ile Gly Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile
165 170 175
Thr Glu Lys Val Val Phe Glu Gln Thr Lys Val Ile Ala Asp Asn Val
180 185 190
Lys Asp Trp Ser Lys Val Val Leu Ala Tyr Glu Pro Val Trp Ala Ile
195 200 205
Gly Thr Gly Lys Thr Ala Thr Pro Gln Gln Ala Gln Glu Val His Glu
210 215 220
Lys Leu Arg Gly Trp Leu Lys Ser Asn Val Ser Asp Ala Val Ala Gln
225 230 235 240
Ser Thr Arg Ile Ile Tyr Gly Gly Ser Val Thr Gly Ala Thr Cys Lys
245 250 255
Glu Leu Ala Ser Gln Pro Asp Val Asp Gly Phe Leu Val Gly Gly Ala
260 265 270
Ser Leu Lys Pro Glu Phe Val Asp Ile Ile Asn Ala Lys Gln
275 280 285
<210> 27
<211> 148
<212> PRT
<213> 智人(Homo sapiens)
<400> 27
Met Phe Arg Arg Pro Val Leu Gln Val Leu Arg Gln Phe Val Arg His
1 5 10 15
Glu Ser Glu Thr Thr Thr Ser Leu Val Leu Glu Arg Ser Leu Asn Arg
20 25 30
Val His Leu Leu Gly Arg Val Gly Gln Asp Pro Val Leu Arg Gln Val
35 40 45
Glu Gly Lys Asn Pro Val Thr Ile Phe Ser Leu Ala Thr Asn Glu Met
50 55 60
Trp Arg Ser Gly Asp Ser Glu Val Tyr Gln Leu Gly Asp Val Ser Gln
65 70 75 80
Lys Thr Thr Trp His Arg Ile Ser Val Phe Arg Pro Gly Leu Arg Asp
85 90 95
Val Ala Tyr Gln Tyr Val Lys Lys Gly Ser Arg Ile Tyr Leu Glu Gly
100 105 110
Lys Ile Asp Tyr Gly Glu Tyr Met Asp Lys Asn Asn Val Arg Arg Gln
115 120 125
Ala Thr Thr Ile Ile Ala Asp Asn Ile Ile Phe Leu Ser Asp Gln Thr
130 135 140
Lys Glu Lys Glu
145
<210> 28
<211> 276
<212> PRT
<213> 智人(Homo sapiens)
<400> 28
Met Ala Leu Leu Asp Val Cys Gly Ala Pro Arg Gly Gln Arg Pro Glu
1 5 10 15
Ser Ala Leu Pro Val Ala Gly Ser Gly Arg Arg Ser Asp Pro Gly His
20 25 30
Tyr Ser Phe Ser Met Arg Ser Pro Glu Leu Ala Leu Pro Arg Gly Met
35 40 45
Gln Pro Thr Glu Phe Phe Gln Ser Leu Gly Gly Asp Gly Glu Arg Asn
50 55 60
Val Gln Ile Glu Met Ala His Gly Thr Thr Thr Leu Ala Phe Lys Phe
65 70 75 80
Gln His Gly Val Ile Ala Ala Val Asp Ser Arg Ala Ser Ala Gly Ser
85 90 95
Tyr Ile Ser Ala Leu Arg Val Asn Lys Val Ile Glu Ile Asn Pro Tyr
100 105 110
Leu Leu Gly Thr Met Ser Gly Cys Ala Ala Asp Cys Gln Tyr Trp Glu
115 120 125
Arg Leu Leu Ala Lys Glu Cys Arg Leu Tyr Tyr Leu Arg Asn Gly Glu
130 135 140
Arg Ile Ser Val Ser Ala Ala Ser Lys Leu Leu Ser Asn Met Met Cys
145 150 155 160
Gln Tyr Arg Gly Met Gly Leu Ser Met Gly Ser Met Ile Cys Gly Trp
165 170 175
Asp Lys Lys Gly Pro Gly Leu Tyr Tyr Val Asp Glu His Gly Thr Arg
180 185 190
Leu Ser Gly Asn Met Phe Ser Thr Gly Ser Gly Asn Thr Tyr Ala Tyr
195 200 205
Gly Val Met Asp Ser Gly Tyr Arg Pro Asn Leu Ser Pro Glu Glu Ala
210 215 220
Tyr Asp Leu Gly Arg Arg Ala Ile Ala Tyr Ala Thr His Arg Asp Ser
225 230 235 240
Tyr Ser Gly Gly Val Val Asn Met Tyr His Met Lys Glu Asp Gly Trp
245 250 255
Val Lys Val Glu Ser Thr Asp Val Ser Asp Leu Leu His Gln Tyr Arg
260 265 270
Glu Ala Asn Gln
275
<210> 29
<211> 524
<212> PRT
<213> 智人(Homo sapiens)
<400> 29
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
1 5 10 15
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
20 25 30
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
35 40 45
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
50 55 60
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65 70 75 80
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
85 90 95
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
100 105 110
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
115 120 125
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
130 135 140
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145 150 155 160
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
165 170 175
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
180 185 190
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
195 200 205
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
210 215 220
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225 230 235 240
Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
245 250 255
Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp
260 265 270
Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala
275 280 285
Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys
290 295 300
His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe
305 310 315 320
Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys
325 330 335
Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser
340 345 350
Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile
355 360 365
Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met
370 375 380
Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val
385 390 395 400
Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val
405 410 415
Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile
420 425 430
Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln
435 440 445
Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu
450 455 460
Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly
465 470 475 480
Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile
485 490 495
Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys
500 505 510
Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
515 520
<210> 30
<211> 277
<212> PRT
<213> 智人(Homo sapiens)
<400> 30
Met Ala Ala Val Ser Val Tyr Ala Pro Pro Val Gly Gly Phe Ser Phe
1 5 10 15
Asp Asn Cys Arg Arg Asn Ala Val Leu Glu Ala Asp Phe Ala Lys Arg
20 25 30
Gly Tyr Lys Leu Pro Lys Val Arg Lys Thr Gly Thr Thr Ile Ala Gly
35 40 45
Val Val Tyr Lys Asp Gly Ile Val Leu Gly Ala Asp Thr Arg Ala Thr
50 55 60
Glu Gly Met Val Val Ala Asp Lys Asn Cys Ser Lys Ile His Phe Ile
65 70 75 80
Ser Pro Asn Ile Tyr Cys Cys Gly Ala Gly Thr Ala Ala Asp Thr Asp
85 90 95
Met Thr Thr Gln Leu Ile Ser Ser Asn Leu Glu Leu His Ser Leu Ser
100 105 110
Thr Gly Arg Leu Pro Arg Val Val Thr Ala Asn Arg Met Leu Lys Gln
115 120 125
Met Leu Phe Arg Tyr Gln Gly Tyr Ile Gly Ala Ala Leu Val Leu Gly
130 135 140
Gly Val Asp Val Thr Gly Pro His Leu Tyr Ser Ile Tyr Pro His Gly
145 150 155 160
Ser Thr Asp Lys Leu Pro Tyr Val Thr Met Gly Ser Gly Ser Leu Ala
165 170 175
Ala Met Ala Val Phe Glu Asp Lys Phe Arg Pro Asp Met Glu Glu Glu
180 185 190
Glu Ala Lys Asn Leu Val Ser Glu Ala Ile Ala Ala Gly Ile Phe Asn
195 200 205
Asp Leu Gly Ser Gly Ser Asn Ile Asp Leu Cys Val Ile Ser Lys Asn
210 215 220
Lys Leu Asp Phe Leu Arg Pro Tyr Thr Val Pro Asn Lys Lys Gly Thr
225 230 235 240
Arg Leu Gly Arg Tyr Arg Cys Glu Lys Gly Thr Thr Ala Val Leu Thr
245 250 255
Glu Lys Ile Thr Pro Leu Glu Ile Glu Val Leu Glu Glu Thr Val Gln
260 265 270
Thr Met Asp Thr Ser
275
<210> 31
<211> 286
<212> PRT
<213> 智人(Homo sapiens)
<400> 31
Met Ala Asp Phe Asp Asp Arg Val Ser Asp Glu Glu Lys Val Arg Ile
1 5 10 15
Ala Ala Lys Phe Ile Thr His Ala Pro Pro Gly Glu Phe Asn Glu Val
20 25 30
Phe Asn Asp Val Arg Leu Leu Leu Asn Asn Asp Asn Leu Leu Arg Glu
35 40 45
Gly Ala Ala His Ala Phe Ala Gln Tyr Asn Met Asp Gln Phe Thr Pro
50 55 60
Val Lys Ile Glu Gly Tyr Glu Asp Gln Val Leu Ile Thr Glu His Gly
65 70 75 80
Asp Leu Gly Asn Ser Arg Phe Leu Asp Pro Arg Asn Lys Ile Ser Phe
85 90 95
Lys Phe Asp His Leu Arg Lys Glu Ala Ser Asp Pro Gln Pro Glu Glu
100 105 110
Ala Asp Gly Gly Leu Lys Ser Trp Arg Glu Ser Cys Asp Ser Ala Leu
115 120 125
Arg Ala Tyr Val Lys Asp His Tyr Ser Asn Gly Phe Cys Thr Val Tyr
130 135 140
Ala Lys Thr Ile Asp Gly Gln Gln Thr Ile Ile Ala Cys Ile Glu Ser
145 150 155 160
His Gln Phe Gln Pro Lys Asn Phe Trp Asn Gly Arg Trp Arg Ser Glu
165 170 175
Trp Lys Phe Thr Ile Thr Pro Pro Thr Ala Gln Val Val Gly Val Leu
180 185 190
Lys Ile Gln Val His Tyr Tyr Glu Asp Gly Asn Val Gln Leu Val Ser
195 200 205
His Lys Asp Val Gln Asp Ser Leu Thr Val Ser Asn Glu Ala Gln Thr
210 215 220
Ala Lys Glu Phe Ile Lys Ile Ile Glu Asn Ala Glu Asn Glu Tyr Gln
225 230 235 240
Thr Ala Ile Ser Glu Asn Tyr Gln Thr Met Ser Asp Thr Thr Phe Lys
245 250 255
Ala Leu Arg Arg Gln Leu Pro Val Thr Arg Thr Lys Ile Asp Trp Asn
260 265 270
Lys Ile Leu Ser Tyr Lys Ile Gly Lys Glu Met Gln Asn Ala
275 280 285
<210> 32
<211> 199
<212> PRT
<213> 智人(Homo sapiens)
<400> 32
Met Ser Ser Gly Asn Ala Lys Ile Gly His Pro Ala Pro Asn Phe Lys
1 5 10 15
Ala Thr Ala Val Met Pro Asp Gly Gln Phe Lys Asp Ile Ser Leu Ser
20 25 30
Asp Tyr Lys Gly Lys Tyr Val Val Phe Phe Phe Tyr Pro Leu Asp Phe
35 40 45
Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Ala Glu
50 55 60
Glu Phe Lys Lys Leu Asn Cys Gln Val Ile Gly Ala Ser Val Asp Ser
65 70 75 80
His Phe Cys His Leu Ala Trp Val Asn Thr Pro Lys Lys Gln Gly Gly
85 90 95
Leu Gly Pro Met Asn Ile Pro Leu Val Ser Asp Pro Lys Arg Thr Ile
100 105 110
Ala Gln Asp Tyr Gly Val Leu Lys Ala Asp Glu Gly Ile Ser Phe Arg
115 120 125
Gly Leu Phe Ile Ile Asp Asp Lys Gly Ile Leu Arg Gln Ile Thr Val
130 135 140
Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Thr Leu Arg Leu Val
145 150 155 160
Gln Ala Phe Gln Phe Thr Asp Lys His Gly Glu Val Cys Pro Ala Gly
165 170 175
Trp Lys Pro Gly Ser Asp Thr Ile Lys Pro Asp Val Gln Lys Ser Lys
180 185 190
Glu Tyr Phe Ser Lys Gln Lys
195
<210> 33
<211> 613
<212> PRT
<213> 智人(Homo sapiens)
<400> 33
Met Ala Gln Ser Arg Val Leu Leu Leu Leu Leu Leu Leu Pro Pro Gln
1 5 10 15
Leu His Leu Gly Pro Val Leu Ala Val Arg Ala Pro Gly Phe Gly Arg
20 25 30
Ser Gly Gly His Ser Leu Ser Pro Glu Glu Asn Glu Phe Ala Glu Glu
35 40 45
Glu Pro Val Leu Val Leu Ser Pro Glu Glu Pro Gly Pro Gly Pro Ala
50 55 60
Ala Val Ser Cys Pro Arg Asp Cys Ala Cys Ser Gln Glu Gly Val Val
65 70 75 80
Asp Cys Gly Gly Ile Asp Leu Arg Glu Phe Pro Gly Asp Leu Pro Glu
85 90 95
His Thr Asn His Leu Ser Leu Gln Asn Asn Gln Leu Glu Lys Ile Tyr
100 105 110
Pro Glu Glu Leu Ser Arg Leu His Arg Leu Glu Thr Leu Asn Leu Gln
115 120 125
Asn Asn Arg Leu Thr Ser Arg Gly Leu Pro Glu Lys Ala Phe Glu His
130 135 140
Leu Thr Asn Leu Asn Tyr Leu Tyr Leu Ala Asn Asn Lys Leu Thr Leu
145 150 155 160
Ala Pro Arg Phe Leu Pro Asn Ala Leu Ile Ser Val Asp Phe Ala Ala
165 170 175
Asn Tyr Leu Thr Lys Ile Tyr Gly Leu Thr Phe Gly Gln Lys Pro Asn
180 185 190
Leu Arg Ser Val Tyr Leu His Asn Asn Lys Leu Ala Asp Ala Gly Leu
195 200 205
Pro Asp Asn Met Phe Asn Gly Ser Ser Asn Val Glu Val Leu Ile Leu
210 215 220
Ser Ser Asn Phe Leu Arg His Val Pro Lys His Leu Pro Pro Ala Leu
225 230 235 240
Tyr Lys Leu His Leu Lys Asn Asn Lys Leu Glu Lys Ile Pro Pro Gly
245 250 255
Ala Phe Ser Glu Leu Ser Ser Leu Arg Glu Leu Tyr Leu Gln Asn Asn
260 265 270
Tyr Leu Thr Asp Glu Gly Leu Asp Asn Glu Thr Phe Trp Lys Leu Ser
275 280 285
Ser Leu Glu Tyr Leu Asp Leu Ser Ser Asn Asn Leu Ser Arg Val Pro
290 295 300
Ala Gly Leu Pro Arg Ser Leu Val Leu Leu His Leu Glu Lys Asn Ala
305 310 315 320
Ile Arg Ser Val Asp Ala Asn Val Leu Thr Pro Ile Arg Ser Leu Glu
325 330 335
Tyr Leu Leu Leu His Ser Asn Gln Leu Arg Glu Gln Gly Ile His Pro
340 345 350
Leu Ala Phe Gln Gly Leu Lys Arg Leu His Thr Val His Leu Tyr Asn
355 360 365
Asn Ala Leu Glu Arg Val Pro Ser Gly Leu Pro Arg Arg Val Arg Thr
370 375 380
Leu Met Ile Leu His Asn Gln Ile Thr Gly Ile Gly Arg Glu Asp Phe
385 390 395 400
Ala Thr Thr Tyr Phe Leu Glu Glu Leu Asn Leu Ser Tyr Asn Arg Ile
405 410 415
Thr Ser Pro Gln Val His Arg Asp Ala Phe Arg Lys Leu Arg Leu Leu
420 425 430
Arg Ser Leu Asp Leu Ser Gly Asn Arg Leu His Thr Leu Pro Pro Gly
435 440 445
Leu Pro Arg Asn Val His Val Leu Lys Val Lys Arg Asn Glu Leu Ala
450 455 460
Ala Leu Ala Arg Gly Ala Leu Val Gly Met Ala Gln Leu Arg Glu Leu
465 470 475 480
Tyr Leu Thr Ser Asn Arg Leu Arg Ser Arg Ala Leu Gly Pro Arg Ala
485 490 495
Trp Val Asp Leu Ala His Leu Gln Leu Leu Asp Ile Ala Gly Asn Gln
500 505 510
Leu Thr Glu Ile Pro Glu Gly Leu Pro Glu Ser Leu Glu Tyr Leu Tyr
515 520 525
Leu Gln Asn Asn Lys Ile Ser Ala Val Pro Ala Asn Ala Phe Asp Ser
530 535 540
Thr Pro Asn Leu Lys Gly Ile Phe Leu Arg Phe Asn Lys Leu Ala Val
545 550 555 560
Gly Ser Val Val Asp Ser Ala Phe Arg Arg Leu Lys His Leu Gln Val
565 570 575
Leu Asp Ile Glu Gly Asn Leu Glu Phe Gly Asp Ile Ser Lys Asp Arg
580 585 590
Gly Arg Leu Gly Lys Glu Lys Glu Glu Glu Glu Glu Glu Glu Glu Glu
595 600 605
Glu Glu Glu Thr Arg
610
<210> 34
<211> 469
<212> PRT
<213> 智人(Homo sapiens)
<400> 34
Met His Ser Phe Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly Val Val
1 5 10 15
Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp
20 25 30
Leu Val Gln Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly
35 40 45
Arg Gln Val Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu
50 55 60
Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp
65 70 75 80
Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp
85 90 95
Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr
100 105 110
His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala
115 120 125
Asp Val Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val
130 135 140
Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met
145 150 155 160
Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly
165 170 175
Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly
180 185 190
Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg
195 200 205
Glu Tyr Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu
210 215 220
Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr
225 230 235 240
Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile
245 250 255
Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro
260 265 270
Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr
275 280 285
Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg
290 295 300
Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe
305 310 315 320
Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp
325 330 335
Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln
340 345 350
Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe
355 360 365
Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu
370 375 380
Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr
385 390 395 400
Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala
405 410 415
His Asp Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys
420 425 430
Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp
435 440 445
Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe
450 455 460
Asn Cys Arg Lys Asn
465
<210> 35
<211> 420
<212> PRT
<213> 智人(Homo sapiens)
<400> 35
Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr
1 5 10 15
Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr
20 25 30
Lys Val Gln Asn Ile His Pro Val Glu Ser Ala Lys Ile Glu Pro Pro
35 40 45
Asp Thr Gly Leu Tyr Tyr Asp Glu Tyr Leu Lys Gln Val Ile Asp Val
50 55 60
Leu Glu Thr Asp Lys His Phe Arg Glu Lys Leu Gln Lys Ala Asp Ile
65 70 75 80
Glu Glu Ile Lys Ser Gly Arg Leu Ser Lys Glu Leu Asp Leu Val Ser
85 90 95
His His Val Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Gly
100 105 110
Arg Leu Arg Met Leu Ile Lys Ala Lys Leu Asp Ser Leu Gln Asp Ile
115 120 125
Gly Met Asp His Gln Ala Leu Leu Lys Gln Phe Asp His Leu Asn His
130 135 140
Leu Asn Pro Asp Lys Phe Glu Ser Thr Asp Leu Asp Met Leu Ile Lys
145 150 155 160
Ala Ala Thr Ser Asp Leu Glu His Tyr Asp Lys Thr Arg His Glu Glu
165 170 175
Phe Lys Lys Tyr Glu Met Met Lys Glu His Glu Arg Arg Glu Tyr Leu
180 185 190
Lys Thr Leu Asn Glu Glu Lys Arg Lys Glu Glu Glu Ser Lys Phe Glu
195 200 205
Glu Met Lys Lys Lys His Glu Asn His Pro Lys Val Asn His Pro Gly
210 215 220
Ser Lys Asp Gln Leu Lys Glu Val Trp Glu Glu Thr Asp Gly Leu Asp
225 230 235 240
Pro Asn Asp Phe Asp Pro Lys Thr Phe Phe Lys Leu His Asp Val Asn
245 250 255
Ser Asp Gly Phe Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys
260 265 270
Glu Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Val
275 280 285
Glu Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Ser Glu
290 295 300
Val Asp Thr Asn Lys Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Lys
305 310 315 320
Ala Thr Glu Lys Lys Glu Phe Leu Glu Pro Asp Ser Trp Glu Thr Leu
325 330 335
Asp Gln Gln Gln Phe Phe Thr Glu Glu Glu Leu Lys Glu Tyr Glu Asn
340 345 350
Ile Ile Ala Leu Gln Glu Asn Glu Leu Lys Lys Lys Ala Asp Glu Leu
355 360 365
Gln Lys Gln Lys Glu Glu Leu Gln Arg Gln His Asp Gln Leu Glu Ala
370 375 380
Gln Lys Leu Glu Tyr His Gln Val Ile Gln Gln Met Glu Gln Lys Lys
385 390 395 400
Leu Gln Gln Gly Ile Pro Pro Ser Gly Pro Ala Gly Glu Leu Lys Phe
405 410 415
Glu Pro His Ile
420
<210> 36
<211> 215
<212> PRT
<213> 智人(Homo sapiens)
<400> 36
Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr
1 5 10 15
Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro
20 25 30
Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg
35 40 45
Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala
50 55 60
Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro
65 70 75 80
Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys
85 90 95
Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys
100 105 110
Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys
115 120 125
Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr
130 135 140
Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala
145 150 155 160
Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val
165 170 175
Lys Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu
180 185 190
Asp Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu
195 200 205
Glu Glu Asp Asp Asp Asp Glu
210 215
<210> 37
<211> 5890
<212> PRT
<213> 智人(Homo sapiens)
<400> 37
Met Glu Lys Glu Glu Thr Thr Arg Glu Leu Leu Leu Pro Asn Trp Gln
1 5 10 15
Gly Ser Gly Ser His Gly Leu Thr Ile Ala Gln Arg Asp Asp Gly Val
20 25 30
Phe Val Gln Glu Val Thr Gln Asn Ser Pro Ala Ala Arg Thr Gly Val
35 40 45
Val Lys Glu Gly Asp Gln Ile Val Gly Ala Thr Ile Tyr Phe Asp Asn
50 55 60
Leu Gln Ser Gly Glu Val Thr Gln Leu Leu Asn Thr Met Gly His His
65 70 75 80
Thr Val Gly Leu Lys Leu His Arg Lys Gly Asp Arg Ser Pro Glu Pro
85 90 95
Gly Gln Thr Trp Thr Arg Glu Val Phe Ser Ser Cys Ser Ser Glu Val
100 105 110
Val Leu Ser Gly Asp Asp Glu Glu Tyr Gln Arg Ile Tyr Thr Thr Lys
115 120 125
Ile Lys Pro Arg Leu Lys Ser Glu Asp Gly Val Glu Gly Asp Leu Gly
130 135 140
Glu Thr Gln Ser Arg Thr Ile Thr Val Thr Arg Arg Val Thr Ala Tyr
145 150 155 160
Thr Val Asp Val Thr Gly Arg Glu Gly Ala Lys Asp Ile Asp Ile Ser
165 170 175
Ser Pro Glu Phe Lys Ile Lys Ile Pro Arg His Glu Leu Thr Glu Ile
180 185 190
Ser Asn Val Asp Val Glu Thr Gln Ser Gly Lys Thr Val Ile Arg Leu
195 200 205
Pro Ser Gly Ser Gly Ala Ala Ser Pro Thr Gly Ser Ala Val Asp Ile
210 215 220
Arg Ala Gly Ala Ile Ser Ala Ser Gly Pro Glu Leu Gln Gly Ala Gly
225 230 235 240
His Ser Lys Leu Gln Val Thr Met Pro Gly Ile Lys Val Gly Gly Ser
245 250 255
Gly Val Asn Val Asn Ala Lys Gly Leu Asp Leu Gly Gly Arg Gly Gly
260 265 270
Val Gln Val Pro Ala Val Asp Ile Ser Ser Ser Leu Gly Gly Arg Ala
275 280 285
Val Glu Val Gln Gly Pro Ser Leu Glu Ser Gly Asp His Gly Lys Ile
290 295 300
Lys Phe Pro Thr Met Lys Val Pro Lys Phe Gly Val Ser Thr Gly Arg
305 310 315 320
Glu Gly Gln Thr Pro Lys Ala Gly Leu Arg Val Ser Ala Pro Glu Val
325 330 335
Ser Val Gly His Lys Gly Gly Lys Pro Gly Leu Thr Ile Gln Ala Pro
340 345 350
Gln Leu Glu Val Ser Val Pro Ser Ala Asn Ile Glu Gly Leu Glu Gly
355 360 365
Lys Leu Lys Gly Pro Gln Ile Thr Gly Pro Ser Leu Glu Gly Asp Leu
370 375 380
Gly Leu Lys Gly Ala Lys Pro Gln Gly His Ile Gly Val Asp Ala Ser
385 390 395 400
Ala Pro Gln Ile Gly Gly Ser Ile Thr Gly Pro Ser Val Glu Val Gln
405 410 415
Ala Pro Asp Ile Asp Val Gln Gly Pro Gly Ser Lys Leu Asn Val Pro
420 425 430
Lys Met Lys Val Pro Lys Phe Ser Val Ser Gly Ala Lys Gly Glu Glu
435 440 445
Thr Gly Ile Asp Val Thr Leu Pro Thr Gly Glu Val Thr Val Pro Gly
450 455 460
Val Ser Gly Asp Val Ser Leu Pro Glu Ile Ala Thr Gly Gly Leu Glu
465 470 475 480
Gly Lys Met Lys Gly Thr Lys Val Lys Thr Pro Glu Met Ile Ile Gln
485 490 495
Lys Pro Lys Ile Ser Met Gln Asp Val Asp Leu Ser Leu Gly Ser Pro
500 505 510
Lys Leu Lys Gly Asp Ile Lys Val Ser Ala Pro Gly Val Gln Gly Asp
515 520 525
Val Lys Gly Pro Gln Val Ala Leu Lys Gly Ser Arg Val Asp Ile Glu
530 535 540
Thr Pro Asn Leu Glu Gly Thr Leu Thr Gly Pro Arg Leu Gly Ser Pro
545 550 555 560
Ser Gly Lys Thr Gly Thr Cys Arg Ile Ser Met Ser Glu Val Asp Leu
565 570 575
Asn Val Ala Ala Pro Lys Val Lys Gly Gly Val Asp Val Thr Leu Pro
580 585 590
Arg Val Glu Gly Lys Val Lys Val Pro Glu Val Asp Val Arg Gly Pro
595 600 605
Lys Val Asp Val Ser Ala Pro Asp Val Glu Ala His Gly Pro Glu Trp
610 615 620
Asn Leu Lys Met Pro Lys Met Lys Met Pro Thr Phe Ser Thr Pro Gly
625 630 635 640
Ala Lys Gly Glu Gly Pro Asp Val His Met Thr Leu Pro Lys Gly Asp
645 650 655
Ile Ser Ile Ser Gly Pro Lys Val Asn Val Glu Ala Pro Asp Val Asn
660 665 670
Leu Glu Gly Leu Gly Gly Lys Leu Lys Gly Pro Asp Val Lys Leu Pro
675 680 685
Asp Met Ser Val Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu
690 695 700
His Val Lys Gly Thr Lys Val Lys Gly Glu Tyr Asp Val Thr Val Pro
705 710 715 720
Lys Leu Glu Gly Glu Leu Lys Gly Pro Lys Val Asp Ile Asp Ala Pro
725 730 735
Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro Lys Met
740 745 750
Lys Met Pro Lys Phe Ser Val Pro Gly Phe Lys Ala Glu Gly Pro Glu
755 760 765
Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys
770 775 780
Ile Asp Val Thr Ala Pro Asp Val Ser Ile Glu Glu Pro Glu Gly Lys
785 790 795 800
Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Val Pro
805 810 815
Lys Ile Ser Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Asn Val
820 825 830
Lys Gly Glu Tyr Asp Val Thr Met Pro Lys Val Glu Ser Glu Ile Lys
835 840 845
Val Pro Asp Val Glu Leu Lys Ser Ala Lys Met Asp Ile Asp Val Pro
850 855 860
Asp Val Glu Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Met
865 870 875 880
Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Ala Glu Gly Pro Glu
885 890 895
Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys
900 905 910
Val Gly Val Glu Val Pro Asp Val Asn Ile Glu Gly Pro Glu Gly Lys
915 920 925
Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro
930 935 940
Lys Ile Ser Met Pro Asp Val Asp Leu His Met Lys Gly Pro Lys Val
945 950 955 960
Lys Gly Glu Tyr Asp Met Thr Val Pro Lys Leu Glu Gly Asp Leu Lys
965 970 975
Gly Pro Lys Val Asp Val Ser Ala Pro Asp Val Glu Met Gln Gly Pro
980 985 990
Asp Trp Asn Leu Lys Met Pro Lys Ile Lys Met Pro Lys Phe Ser Met
995 1000 1005
Pro Ser Leu Lys Gly Glu Gly Pro Glu Phe Asp Val Asn Leu Ser
1010 1015 1020
Lys Ala Asn Val Asp Ile Ser Ala Pro Lys Val Asp Thr Asn Ala
1025 1030 1035
Pro Asp Leu Ser Leu Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro
1040 1045 1050
Lys Phe Lys Met Pro Glu Met His Phe Arg Ala Pro Lys Met Ser
1055 1060 1065
Leu Pro Asp Val Asp Leu Asp Leu Lys Gly Pro Lys Met Lys Gly
1070 1075 1080
Asn Val Asp Ile Ser Ala Pro Lys Ile Glu Gly Glu Met Gln Val
1085 1090 1095
Pro Asp Val Asp Ile Arg Gly Pro Lys Val Asp Ile Lys Ala Pro
1100 1105 1110
Asp Val Glu Gly Gln Gly Leu Asp Trp Ser Leu Lys Ile Pro Lys
1115 1120 1125
Met Lys Met Pro Lys Phe Ser Met Pro Ser Leu Lys Gly Glu Gly
1130 1135 1140
Pro Glu Val Asp Val Asn Leu Pro Lys Ala Asp Val Val Val Ser
1145 1150 1155
Gly Pro Lys Val Asp Ile Glu Ala Pro Asp Val Ser Leu Glu Gly
1160 1165 1170
Pro Glu Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met
1175 1180 1185
His Phe Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu His
1190 1195 1200
Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val Ser Val Pro
1205 1210 1215
Lys Val Glu Gly Glu Met Lys Val Pro Asp Val Glu Ile Lys Gly
1220 1225 1230
Pro Lys Met Asp Ile Asp Ala Pro Asp Val Glu Val Gln Gly Pro
1235 1240 1245
Asp Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser
1250 1255 1260
Met Pro Gly Phe Lys Gly Glu Gly Arg Glu Val Asp Val Asn Leu
1265 1270 1275
Pro Lys Ala Asp Ile Asp Val Ser Gly Pro Lys Val Asp Val Glu
1280 1285 1290
Val Pro Asp Val Ser Leu Glu Gly Pro Glu Gly Lys Leu Lys Gly
1295 1300 1305
Pro Lys Phe Lys Met Pro Glu Met His Phe Lys Ala Pro Lys Ile
1310 1315 1320
Ser Met Pro Asp Val Asp Leu Asn Leu Lys Gly Pro Lys Leu Lys
1325 1330 1335
Gly Asp Val Asp Val Ser Leu Pro Glu Val Glu Gly Glu Met Lys
1340 1345 1350
Val Pro Asp Val Asp Ile Lys Gly Pro Lys Val Asp Ile Ser Ala
1355 1360 1365
Pro Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro
1370 1375 1380
Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu
1385 1390 1395
Gly Pro Glu Val Asp Val Lys Leu Pro Lys Ala Asp Val Asp Val
1400 1405 1410
Ser Gly Pro Lys Met Asp Ala Glu Val Pro Asp Val Asn Ile Glu
1415 1420 1425
Gly Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu
1430 1435 1440
Met Ser Ile Lys Pro Gln Lys Ile Ser Ile Pro Asp Val Gly Leu
1445 1450 1455
His Leu Lys Gly Pro Lys Met Lys Gly Asp Tyr Asp Val Thr Val
1460 1465 1470
Pro Lys Val Glu Gly Glu Ile Lys Ala Pro Asp Val Asp Ile Lys
1475 1480 1485
Gly Pro Lys Val Asp Ile Asn Ala Pro Asp Val Glu Val His Gly
1490 1495 1500
Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro Lys Phe
1505 1510 1515
Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Glu Val Asp Met Asn
1520 1525 1530
Leu Pro Lys Ala Asp Leu Gly Val Ser Gly Pro Lys Val Asp Ile
1535 1540 1545
Asp Val Pro Asp Val Asn Leu Glu Ala Pro Glu Gly Lys Leu Lys
1550 1555 1560
Gly Pro Lys Phe Lys Met Pro Ser Met Asn Ile Gln Thr His Lys
1565 1570 1575
Ile Ser Met Pro Asp Val Gly Leu Asn Leu Lys Ala Pro Lys Leu
1580 1585 1590
Lys Thr Asp Val Asp Val Ser Leu Pro Lys Val Glu Gly Asp Leu
1595 1600 1605
Lys Gly Pro Glu Ile Asp Val Lys Ala Pro Lys Met Asp Val Asn
1610 1615 1620
Val Gly Asp Ile Asp Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly
1625 1630 1635
Pro Lys Phe Lys Met Pro Glu Met His Phe Lys Ala Pro Lys Ile
1640 1645 1650
Ser Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Lys Val Lys
1655 1660 1665
Gly Asp Met Asp Val Ser Val Pro Lys Val Glu Gly Glu Met Lys
1670 1675 1680
Val Pro Asp Val Asp Ile Lys Gly Pro Lys Val Asp Ile Asp Ala
1685 1690 1695
Pro Asp Val Glu Val His Asp Pro Asp Trp His Leu Lys Met Pro
1700 1705 1710
Lys Met Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Ala Glu
1715 1720 1725
Gly Pro Glu Val Asp Val Asn Leu Pro Lys Ala Asp Ile Asp Val
1730 1735 1740
Ser Gly Pro Ser Val Asp Thr Asp Ala Pro Asp Leu Asp Ile Glu
1745 1750 1755
Gly Pro Glu Gly Lys Leu Lys Gly Ser Lys Phe Lys Met Pro Lys
1760 1765 1770
Leu Asn Ile Lys Ala Pro Lys Val Ser Met Pro Asp Val Asp Leu
1775 1780 1785
Asn Leu Lys Gly Pro Lys Leu Lys Gly Glu Ile Asp Ala Ser Val
1790 1795 1800
Pro Glu Leu Glu Gly Asp Leu Arg Gly Pro Gln Val Asp Val Lys
1805 1810 1815
Gly Pro Phe Val Glu Ala Glu Val Pro Asp Val Asp Leu Glu Cys
1820 1825 1830
Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met
1835 1840 1845
His Phe Lys Ala Pro Lys Ile Ser Met Pro Asp Val Asp Leu His
1850 1855 1860
Leu Lys Gly Pro Lys Val Lys Gly Asp Ala Asp Val Ser Val Pro
1865 1870 1875
Lys Leu Glu Gly Asp Leu Thr Gly Pro Ser Val Gly Val Glu Val
1880 1885 1890
Pro Asp Val Glu Leu Glu Cys Pro Asp Ala Lys Leu Lys Gly Pro
1895 1900 1905
Lys Phe Lys Met Pro Asp Met His Phe Lys Ala Pro Lys Ile Ser
1910 1915 1920
Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Lys Val Lys Gly
1925 1930 1935
Asp Val Asp Val Ser Val Pro Lys Leu Glu Gly Asp Leu Thr Gly
1940 1945 1950
Pro Ser Val Gly Val Glu Val Pro Asp Val Glu Leu Glu Cys Pro
1955 1960 1965
Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His
1970 1975 1980
Phe Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu His Leu
1985 1990 1995
Lys Gly Pro Lys Val Lys Gly Asp Met Asp Val Ser Val Pro Lys
2000 2005 2010
Val Glu Gly Glu Met Lys Val Pro Asp Val Asp Ile Lys Gly Pro
2015 2020 2025
Lys Met Asp Ile Asp Ala Pro Asp Val Asp Val His Gly Pro Asp
2030 2035 2040
Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser Met
2045 2050 2055
Pro Gly Phe Lys Ala Glu Gly Pro Glu Val Asp Val Asn Leu Pro
2060 2065 2070
Lys Ala Asp Val Val Val Ser Gly Pro Lys Val Asp Val Glu Val
2075 2080 2085
Pro Asp Val Ser Leu Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro
2090 2095 2100
Lys Leu Lys Met Pro Glu Met His Phe Lys Ala Pro Lys Ile Ser
2105 2110 2115
Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Lys Val Lys Gly
2120 2125 2130
Asp Val Asp Val Ser Leu Pro Lys Leu Glu Gly Asp Leu Thr Gly
2135 2140 2145
Pro Ser Val Asp Val Glu Val Pro Asp Val Glu Leu Glu Cys Pro
2150 2155 2160
Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His
2165 2170 2175
Phe Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asn Leu Asn Leu
2180 2185 2190
Lys Gly Pro Lys Val Lys Gly Asp Met Asp Val Ser Val Pro Lys
2195 2200 2205
Val Glu Gly Glu Met Lys Val Pro Asp Val Asp Ile Arg Gly Pro
2210 2215 2220
Lys Val Asp Ile Asp Ala Pro Asp Val Asp Val His Gly Pro Asp
2225 2230 2235
Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser Met
2240 2245 2250
Pro Gly Phe Lys Gly Glu Gly Pro Glu Val Asp Val Asn Leu Pro
2255 2260 2265
Lys Ala Asp Val Asp Val Ser Gly Pro Lys Val Asp Val Glu Val
2270 2275 2280
Pro Asp Val Ser Leu Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro
2285 2290 2295
Lys Phe Lys Met Pro Glu Met His Phe Lys Thr Pro Lys Ile Ser
2300 2305 2310
Met Pro Asp Val Asp Phe Asn Leu Lys Gly Pro Lys Ile Lys Gly
2315 2320 2325
Asp Val Asp Val Ser Ala Pro Lys Leu Glu Gly Glu Leu Lys Gly
2330 2335 2340
Pro Glu Leu Asp Val Lys Gly Pro Lys Leu Asp Ala Asp Met Pro
2345 2350 2355
Glu Val Ala Val Glu Gly Pro Asn Gly Lys Trp Lys Thr Pro Lys
2360 2365 2370
Phe Lys Met Pro Asp Met His Phe Lys Ala Pro Lys Ile Ser Met
2375 2380 2385
Pro Asp Leu Asp Leu His Leu Lys Ser Pro Lys Ala Lys Gly Glu
2390 2395 2400
Val Asp Val Asp Val Pro Lys Leu Glu Gly Asp Leu Lys Gly Pro
2405 2410 2415
His Val Asp Val Ser Gly Pro Asp Ile Asp Ile Glu Gly Pro Glu
2420 2425 2430
Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Asp Met His Phe
2435 2440 2445
Lys Ala Pro Asn Ile Ser Met Pro Asp Val Asp Leu Asn Leu Lys
2450 2455 2460
Gly Pro Lys Ile Lys Gly Asp Val Asp Val Ser Val Pro Glu Val
2465 2470 2475
Glu Gly Lys Leu Glu Val Pro Asp Met Asn Ile Arg Gly Pro Lys
2480 2485 2490
Val Asp Val Asn Ala Pro Asp Val Gln Ala Pro Asp Trp His Leu
2495 2500 2505
Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser Met Pro Gly Phe
2510 2515 2520
Lys Ala Glu Gly Pro Glu Val Asp Val Asn Leu Pro Lys Ala Asp
2525 2530 2535
Val Asp Ile Ser Gly Pro Lys Val Asp Ile Glu Gly Pro Asp Val
2540 2545 2550
Asn Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro Lys Leu Lys
2555 2560 2565
Met Pro Glu Met Asn Ile Lys Ala Pro Lys Ile Ser Met Pro Asp
2570 2575 2580
Phe Asp Leu His Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp
2585 2590 2595
Val Ser Leu Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu Val
2600 2605 2610
Asp Ile Lys Gly Pro Lys Val Asp Ile Asn Ala Pro Asp Val Gly
2615 2620 2625
Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met
2630 2635 2640
Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Gly
2645 2650 2655
Asp Val Lys Leu Pro Lys Ala Asp Ile Asp Val Ser Gly Pro Lys
2660 2665 2670
Val Asp Ile Glu Gly Pro Asp Val Asn Ile Glu Gly Pro Glu Gly
2675 2680 2685
Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys
2690 2695 2700
Ala Pro Lys Ile Ser Met Pro Asp Ile Asp Leu Asn Leu Lys Gly
2705 2710 2715
Pro Lys Val Lys Gly Asp Val Asp Val Ser Leu Pro Lys Val Glu
2720 2725 2730
Gly Asp Leu Lys Gly Pro Glu Val Asp Ile Lys Gly Pro Lys Val
2735 2740 2745
Asp Ile Asp Ala Pro Asp Val Asp Val His Gly Pro Asp Trp His
2750 2755 2760
Leu Lys Met Pro Lys Ile Lys Met Pro Lys Ile Ser Met Pro Gly
2765 2770 2775
Phe Lys Gly Glu Gly Pro Asp Val Asp Val Asn Leu Pro Lys Ala
2780 2785 2790
Asp Ile Asp Val Ser Gly Pro Lys Val Asp Val Glu Cys Pro Asp
2795 2800 2805
Val Asn Ile Glu Gly Pro Glu Gly Lys Trp Lys Ser Pro Lys Phe
2810 2815 2820
Lys Met Pro Glu Met His Phe Lys Thr Pro Lys Ile Ser Met Pro
2825 2830 2835
Asp Ile Asp Leu Asn Leu Thr Gly Pro Lys Ile Lys Gly Asp Val
2840 2845 2850
Asp Val Thr Gly Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu
2855 2860 2865
Val Asp Leu Lys Gly Pro Lys Val Asp Ile Asp Val Pro Asp Val
2870 2875 2880
Asn Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Met Lys
2885 2890 2895
Met Pro Lys Phe Ser Met Pro Gly Phe Lys Ala Glu Gly Pro Glu
2900 2905 2910
Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Val Ser Gly Pro
2915 2920 2925
Lys Val Asp Val Glu Gly Pro Asp Val Asn Ile Glu Gly Pro Glu
2930 2935 2940
Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile
2945 2950 2955
Lys Ala Pro Lys Ile Pro Met Pro Asp Phe Asp Leu His Leu Lys
2960 2965 2970
Gly Pro Lys Val Lys Gly Asp Val Asp Ile Ser Leu Pro Lys Val
2975 2980 2985
Glu Gly Asp Leu Lys Gly Pro Glu Val Asp Ile Arg Gly Pro Gln
2990 2995 3000
Val Asp Ile Asp Val Pro Asp Val Gly Val Gln Gly Pro Asp Trp
3005 3010 3015
His Leu Lys Met Pro Lys Val Lys Met Pro Lys Phe Ser Met Pro
3020 3025 3030
Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val Asn Leu Pro Lys
3035 3040 3045
Ala Asp Leu Asp Val Ser Gly Pro Lys Val Asp Ile Asp Val Pro
3050 3055 3060
Asp Val Asn Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro Lys
3065 3070 3075
Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro Lys Ile Ser Met
3080 3085 3090
Pro Asp Ile Asp Leu Asn Leu Lys Gly Pro Lys Val Lys Gly Asp
3095 3100 3105
Met Asp Val Ser Leu Pro Lys Val Glu Gly Asp Met Lys Val Pro
3110 3115 3120
Asp Val Asp Ile Lys Gly Pro Lys Val Asp Ile Asn Ala Pro Asp
3125 3130 3135
Val Asp Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Ile
3140 3145 3150
Lys Met Pro Lys Ile Ser Met Pro Gly Phe Lys Gly Glu Gly Pro
3155 3160 3165
Glu Val Asp Val Asn Leu Pro Lys Ala Asp Leu Asp Val Ser Gly
3170 3175 3180
Pro Lys Val Asp Val Asp Val Pro Asp Val Asn Ile Glu Gly Pro
3185 3190 3195
Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn
3200 3205 3210
Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Leu Asp Leu Asn Leu
3215 3220 3225
Lys Gly Pro Lys Met Lys Gly Glu Val Asp Val Ser Leu Ala Asn
3230 3235 3240
Val Glu Gly Asp Leu Lys Gly Pro Ala Leu Asp Ile Lys Gly Pro
3245 3250 3255
Lys Ile Asp Val Asp Ala Pro Asp Ile Asp Ile His Gly Pro Asp
3260 3265 3270
Ala Lys Leu Lys Gly Pro Lys Leu Lys Met Pro Asp Met His Val
3275 3280 3285
Asn Met Pro Lys Ile Ser Met Pro Glu Ile Asp Leu Asn Leu Lys
3290 3295 3300
Gly Ser Lys Leu Lys Gly Asp Val Asp Val Ser Gly Pro Lys Leu
3305 3310 3315
Glu Gly Asp Ile Lys Ala Pro Ser Leu Asp Ile Lys Gly Pro Glu
3320 3325 3330
Val Asp Val Ser Gly Pro Lys Leu Asn Ile Glu Gly Lys Ser Lys
3335 3340 3345
Lys Ser Arg Phe Lys Leu Pro Lys Phe Asn Phe Ser Gly Ser Lys
3350 3355 3360
Val Gln Thr Pro Glu Val Asp Val Lys Gly Lys Lys Pro Asp Ile
3365 3370 3375
Asp Ile Thr Gly Pro Lys Val Asp Ile Asn Ala Pro Asp Val Glu
3380 3385 3390
Val Gln Gly Lys Val Lys Gly Ser Lys Phe Lys Met Pro Phe Leu
3395 3400 3405
Ser Ile Ser Ser Pro Lys Val Ser Met Pro Asp Val Glu Leu Asn
3410 3415 3420
Leu Lys Ser Pro Lys Val Lys Gly Asp Leu Asp Ile Ala Gly Pro
3425 3430 3435
Asn Leu Glu Gly Asp Phe Lys Gly Pro Lys Val Asp Ile Lys Ala
3440 3445 3450
Pro Glu Val Asn Leu Asn Ala Pro Asp Val Asp Val His Gly Pro
3455 3460 3465
Asp Trp Asn Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser
3470 3475 3480
Val Ser Gly Leu Lys Ala Glu Gly Pro Asp Val Ala Val Asp Leu
3485 3490 3495
Pro Lys Gly Asp Ile Asn Ile Glu Gly Pro Ser Met Asn Ile Glu
3500 3505 3510
Gly Pro Asp Leu Asn Val Glu Gly Pro Glu Gly Gly Leu Lys Gly
3515 3520 3525
Pro Lys Phe Lys Met Pro Asp Met Asn Ile Lys Ala Pro Lys Ile
3530 3535 3540
Ser Met Pro Asp Ile Asp Leu Asn Leu Lys Gly Pro Lys Val Lys
3545 3550 3555
Gly Asp Val Asp Ile Ser Leu Pro Lys Leu Glu Gly Asp Leu Lys
3560 3565 3570
Gly Pro Glu Val Asp Ile Lys Gly Pro Lys Val Asp Ile Asn Ala
3575 3580 3585
Pro Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro
3590 3595 3600
Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu
3605 3610 3615
Gly Pro Glu Val Asp Val Thr Leu Pro Lys Ala Asp Ile Asp Ile
3620 3625 3630
Ser Gly Pro Asn Val Asp Val Asp Val Pro Asp Val Asn Ile Glu
3635 3640 3645
Gly Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu
3650 3655 3660
Met Asn Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Phe Asp Leu
3665 3670 3675
Asn Leu Lys Gly Pro Lys Met Lys Gly Asp Val Val Val Ser Leu
3680 3685 3690
Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu Val Asp Ile Lys
3695 3700 3705
Gly Pro Lys Val Asp Ile Asp Thr Pro Asp Ile Asn Ile Glu Gly
3710 3715 3720
Ser Glu Gly Lys Phe Lys Gly Pro Lys Phe Lys Ile Pro Glu Met
3725 3730 3735
His Leu Lys Ala Pro Lys Ile Ser Met Pro Asp Ile Asp Leu Asn
3740 3745 3750
Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val Ser Leu Pro
3755 3760 3765
Lys Met Glu Gly Asp Leu Lys Gly Pro Glu Val Asp Ile Lys Gly
3770 3775 3780
Pro Lys Val Asp Ile Asn Ala Pro Asp Val Asp Val Gln Gly Pro
3785 3790 3795
Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro Lys Phe Ser
3800 3805 3810
Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val Asn Leu
3815 3820 3825
Pro Lys Ala Asp Leu Asp Val Ser Gly Pro Lys Val Asp Ile Asp
3830 3835 3840
Val Pro Asp Val Asn Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly
3845 3850 3855
Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro Lys Ile
3860 3865 3870
Ser Met Pro Asp Ile Asp Leu Asn Leu Lys Gly Pro Lys Val Lys
3875 3880 3885
Gly Asp Met Asp Val Ser Leu Pro Lys Val Glu Gly Asp Met Gln
3890 3895 3900
Val Pro Asp Leu Asp Ile Lys Gly Pro Lys Val Asp Ile Asn Ala
3905 3910 3915
Pro Asp Val Asp Val Arg Gly Pro Asp Trp His Leu Lys Met Pro
3920 3925 3930
Lys Ile Lys Met Pro Lys Ile Ser Met Pro Gly Phe Lys Gly Glu
3935 3940 3945
Gly Pro Glu Val Asp Val Asn Leu Pro Lys Ala Asp Leu Asp Val
3950 3955 3960
Ser Gly Pro Lys Val Asp Val Asp Val Pro Asp Val Asn Ile Glu
3965 3970 3975
Gly Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu
3980 3985 3990
Met Asn Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Phe Asp Leu
3995 4000 4005
His Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val Ser Leu
4010 4015 4020
Pro Lys Met Glu Gly Asp Leu Lys Ala Pro Glu Val Asp Ile Lys
4025 4030 4035
Gly Pro Lys Val Asp Ile Asp Ala Pro Asp Val Asp Val His Gly
4040 4045 4050
Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro Lys Phe
4055 4060 4065
Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Glu Val Asp Val Asn
4070 4075 4080
Leu Pro Lys Ala Asp Ile Asp Val Ser Gly Pro Lys Val Asp Ile
4085 4090 4095
Asp Thr Pro Asp Ile Asp Ile His Gly Pro Glu Gly Lys Leu Lys
4100 4105 4110
Gly Pro Lys Phe Lys Met Pro Asp Leu His Leu Lys Ala Pro Lys
4115 4120 4125
Ile Ser Met Pro Glu Val Asp Leu Asn Leu Lys Gly Pro Lys Met
4130 4135 4140
Lys Gly Asp Val Asp Val Ser Leu Pro Lys Val Glu Gly Asp Leu
4145 4150 4155
Lys Gly Pro Glu Val Asp Ile Lys Gly Pro Lys Val Asp Ile Asp
4160 4165 4170
Val Pro Asp Val Asp Val Gln Gly Pro Asp Trp His Leu Lys Met
4175 4180 4185
Pro Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly
4190 4195 4200
Glu Gly Pro Asp Val Asp Val Asn Leu Pro Lys Ala Asp Leu Asp
4205 4210 4215
Val Ser Gly Pro Lys Val Asp Ile Asp Val Pro Asp Val Asn Ile
4220 4225 4230
Glu Gly Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro
4235 4240 4245
Glu Met Asn Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Phe Asp
4250 4255 4260
Leu His Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val Ser
4265 4270 4275
Leu Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu Val Asp Ile
4280 4285 4290
Lys Gly Pro Lys Val Asp Ile Asp Ala Pro Asp Val Asp Val His
4295 4300 4305
Gly Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro Lys
4310 4315 4320
Phe Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val
4325 4330 4335
Thr Leu Pro Lys Ala Asp Ile Glu Ile Ser Gly Pro Lys Val Asp
4340 4345 4350
Ile Asp Ala Pro Asp Val Ser Ile Glu Gly Pro Asp Ala Lys Leu
4355 4360 4365
Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro
4370 4375 4380
Lys Ile Ser Met Pro Asp Ile Asp Phe Asn Leu Lys Gly Pro Lys
4385 4390 4395
Val Lys Gly Asp Val Asp Val Ser Leu Pro Lys Val Glu Gly Asp
4400 4405 4410
Leu Lys Gly Pro Glu Ile Asp Ile Lys Gly Pro Ser Leu Asp Ile
4415 4420 4425
Asp Thr Pro Asp Val Asn Ile Glu Gly Pro Glu Gly Lys Leu Lys
4430 4435 4440
Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro Lys
4445 4450 4455
Ile Ser Met Pro Asp Phe Asp Leu His Leu Lys Gly Pro Lys Val
4460 4465 4470
Lys Gly Asp Val Asp Val Ser Leu Pro Lys Val Glu Ser Asp Leu
4475 4480 4485
Lys Gly Pro Glu Val Asp Ile Glu Gly Pro Glu Gly Lys Leu Lys
4490 4495 4500
Gly Pro Lys Phe Lys Met Pro Asp Val His Phe Lys Ser Pro Gln
4505 4510 4515
Ile Ser Met Ser Asp Ile Asp Leu Asn Leu Lys Gly Pro Lys Ile
4520 4525 4530
Lys Gly Asp Met Asp Ile Ser Val Pro Lys Leu Glu Gly Asp Leu
4535 4540 4545
Lys Gly Pro Lys Val Asp Val Lys Gly Pro Lys Val Gly Ile Asp
4550 4555 4560
Thr Pro Asp Ile Asp Ile His Gly Pro Glu Gly Lys Leu Lys Gly
4565 4570 4575
Pro Lys Phe Lys Met Pro Asp Leu His Leu Lys Ala Pro Lys Ile
4580 4585 4590
Ser Met Pro Glu Val Asp Leu Asn Leu Lys Gly Pro Lys Val Lys
4595 4600 4605
Gly Asp Met Asp Ile Ser Leu Pro Lys Val Glu Gly Asp Leu Lys
4610 4615 4620
Gly Pro Glu Val Asp Ile Arg Asp Pro Lys Val Asp Ile Asp Val
4625 4630 4635
Pro Asp Val Asp Val Gln Gly Pro Asp Trp His Leu Lys Met Pro
4640 4645 4650
Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu
4655 4660 4665
Gly Pro Asp Val Asp Val Asn Leu Pro Lys Ala Asp Ile Asp Val
4670 4675 4680
Ser Gly Pro Lys Val Asp Val Asp Val Pro Asp Val Asn Ile Glu
4685 4690 4695
Gly Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu
4700 4705 4710
Met Ser Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Ile Asp Leu
4715 4720 4725
Asn Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val Thr Leu
4730 4735 4740
Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu Ala Asp Ile Lys
4745 4750 4755
Gly Pro Lys Val Asp Ile Asn Thr Pro Asp Val Asp Val His Gly
4760 4765 4770
Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro Lys Phe
4775 4780 4785
Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val Ser
4790 4795 4800
Leu Pro Lys Ala Asp Ile Asp Val Ser Gly Pro Lys Val Asp Val
4805 4810 4815
Asp Ile Pro Asp Val Asn Ile Glu Gly Pro Asp Ala Lys Leu Lys
4820 4825 4830
Gly Pro Lys Phe Lys Met Pro Glu Ile Asn Ile Lys Ala Pro Lys
4835 4840 4845
Ile Ser Ile Pro Asp Val Asp Leu Asp Leu Lys Gly Pro Lys Val
4850 4855 4860
Lys Gly Asp Phe Asp Val Ser Val Pro Lys Val Glu Gly Thr Leu
4865 4870 4875
Lys Gly Pro Glu Val Asp Leu Lys Gly Pro Arg Leu Asp Phe Glu
4880 4885 4890
Gly Pro Asp Ala Lys Leu Ser Gly Pro Ser Leu Lys Met Pro Ser
4895 4900 4905
Leu Glu Ile Ser Ala Pro Lys Val Thr Ala Pro Asp Val Asp Leu
4910 4915 4920
His Leu Lys Ala Pro Lys Ile Gly Phe Ser Gly Pro Lys Leu Glu
4925 4930 4935
Gly Gly Glu Val Asp Leu Lys Gly Pro Lys Val Glu Ala Pro Ser
4940 4945 4950
Leu Asp Val His Met Asp Ser Pro Asp Ile Asn Ile Glu Gly Pro
4955 4960 4965
Asp Val Lys Ile Pro Lys Phe Lys Lys Pro Lys Phe Gly Phe Gly
4970 4975 4980
Ala Lys Ser Pro Lys Ala Asp Ile Lys Ser Pro Ser Leu Asp Val
4985 4990 4995
Thr Val Pro Glu Ala Glu Leu Asn Leu Glu Thr Pro Glu Ile Ser
5000 5005 5010
Val Gly Gly Lys Gly Lys Lys Ser Lys Phe Lys Met Pro Lys Ile
5015 5020 5025
His Met Ser Gly Pro Lys Ile Lys Ala Lys Lys Gln Gly Phe Asp
5030 5035 5040
Leu Asn Val Pro Gly Gly Glu Ile Asp Ala Ser Leu Lys Ala Pro
5045 5050 5055
Asp Val Asp Val Asn Ile Ala Gly Pro Asp Ala Ala Leu Lys Val
5060 5065 5070
Asp Val Lys Ser Pro Lys Thr Lys Lys Thr Met Phe Gly Lys Met
5075 5080 5085
Tyr Phe Pro Asp Val Glu Phe Asp Ile Lys Ser Pro Lys Phe Lys
5090 5095 5100
Ala Glu Ala Pro Leu Pro Ser Pro Lys Leu Glu Gly Glu Leu Gln
5105 5110 5115
Ala Pro Asp Leu Glu Leu Ser Leu Pro Ala Ile His Val Glu Gly
5120 5125 5130
Leu Asp Ile Lys Ala Lys Ala Pro Lys Val Lys Met Pro Asp Val
5135 5140 5145
Asp Ile Ser Val Pro Lys Ile Glu Gly Asp Leu Lys Gly Pro Lys
5150 5155 5160
Val Gln Ala Asn Leu Gly Ala Pro Asp Ile Asn Ile Glu Gly Leu
5165 5170 5175
Asp Ala Lys Val Lys Thr Pro Ser Phe Gly Ile Ser Ala Pro Gln
5180 5185 5190
Val Ser Ile Pro Asp Val Asn Val Asn Leu Lys Gly Pro Lys Ile
5195 5200 5205
Lys Gly Asp Val Pro Ser Val Gly Leu Glu Gly Pro Asp Val Asp
5210 5215 5220
Leu Gln Gly Pro Glu Ala Lys Ile Lys Phe Pro Lys Phe Ser Met
5225 5230 5235
Pro Lys Ile Gly Ile Pro Gly Val Lys Met Glu Gly Gly Gly Ala
5240 5245 5250
Glu Val His Ala Gln Leu Pro Ser Leu Glu Gly Asp Leu Arg Gly
5255 5260 5265
Pro Asp Val Lys Leu Glu Gly Pro Asp Val Ser Leu Lys Gly Pro
5270 5275 5280
Gly Val Asp Leu Pro Ser Val Asn Leu Ser Met Pro Lys Val Ser
5285 5290 5295
Gly Pro Asp Leu Asp Leu Asn Leu Lys Gly Pro Ser Leu Lys Gly
5300 5305 5310
Asp Leu Asp Ala Ser Val Pro Ser Met Lys Val His Ala Pro Gly
5315 5320 5325
Leu Asn Leu Ser Gly Val Gly Gly Lys Met Gln Val Gly Gly Asp
5330 5335 5340
Gly Val Lys Val Pro Gly Ile Asp Ala Thr Thr Lys Leu Asn Val
5345 5350 5355
Gly Ala Pro Asp Val Thr Leu Arg Gly Pro Ser Leu Gln Gly Asp
5360 5365 5370
Leu Ala Val Ser Gly Asp Ile Lys Cys Pro Lys Val Ser Val Gly
5375 5380 5385
Ala Pro Asp Leu Ser Leu Glu Ala Ser Glu Gly Ser Ile Lys Leu
5390 5395 5400
Pro Lys Met Lys Leu Pro Gln Phe Gly Ile Ser Thr Pro Gly Ser
5405 5410 5415
Asp Leu His Val Asn Ala Lys Gly Pro Gln Val Ser Gly Glu Leu
5420 5425 5430
Lys Gly Pro Gly Val Asp Val Asn Leu Lys Gly Pro Arg Ile Ser
5435 5440 5445
Ala Pro Asn Val Asp Phe Asn Leu Glu Gly Pro Lys Val Lys Gly
5450 5455 5460
Ser Leu Gly Ala Thr Gly Glu Ile Lys Gly Pro Thr Val Gly Gly
5465 5470 5475
Gly Leu Pro Gly Ile Gly Val Gln Gly Leu Glu Gly Asn Leu Gln
5480 5485 5490
Met Pro Gly Ile Lys Ser Ser Gly Cys Asp Val Asn Leu Pro Gly
5495 5500 5505
Val Asn Val Lys Leu Pro Thr Gly Gln Ile Ser Gly Pro Glu Ile
5510 5515 5520
Lys Gly Gly Leu Lys Gly Ser Glu Val Gly Phe His Gly Ala Ala
5525 5530 5535
Pro Asp Ile Ser Val Lys Gly Pro Ala Phe Asn Met Ala Ser Pro
5540 5545 5550
Glu Ser Asp Phe Gly Ile Asn Leu Lys Gly Pro Lys Ile Lys Gly
5555 5560 5565
Gly Ala Asp Val Ser Gly Gly Val Ser Ala Pro Asp Ile Ser Leu
5570 5575 5580
Gly Glu Gly His Leu Ser Val Lys Gly Ser Gly Gly Glu Trp Lys
5585 5590 5595
Gly Pro Gln Val Ser Ser Ala Leu Asn Leu Asp Thr Ser Lys Phe
5600 5605 5610
Ala Gly Gly Leu His Phe Ser Gly Pro Lys Val Glu Gly Gly Val
5615 5620 5625
Lys Gly Gly Gln Ile Gly Leu Gln Ala Pro Gly Leu Ser Val Ser
5630 5635 5640
Gly Pro Gln Gly His Leu Glu Ser Gly Ser Gly Lys Val Thr Phe
5645 5650 5655
Pro Lys Met Lys Ile Pro Lys Phe Thr Phe Ser Gly Arg Glu Leu
5660 5665 5670
Val Gly Arg Glu Met Gly Val Asp Val His Phe Pro Lys Ala Glu
5675 5680 5685
Ala Ser Ile Gln Ala Gly Ala Gly Asp Gly Glu Trp Glu Glu Ser
5690 5695 5700
Glu Val Lys Leu Lys Lys Ser Lys Ile Lys Met Pro Lys Phe Asn
5705 5710 5715
Phe Ser Lys Pro Lys Gly Lys Gly Gly Val Thr Gly Ser Pro Glu
5720 5725 5730
Ala Ser Ile Ser Gly Ser Lys Gly Asp Leu Lys Ser Ser Lys Ala
5735 5740 5745
Ser Leu Gly Ser Leu Glu Gly Glu Ala Glu Ala Glu Ala Ser Ser
5750 5755 5760
Pro Lys Gly Lys Phe Ser Leu Phe Lys Ser Lys Lys Pro Arg His
5765 5770 5775
Arg Ser Asn Ser Phe Ser Asp Glu Arg Glu Phe Ser Gly Pro Ser
5780 5785 5790
Thr Pro Thr Gly Thr Leu Glu Phe Glu Gly Gly Glu Val Ser Leu
5795 5800 5805
Glu Gly Gly Lys Val Lys Gly Lys His Gly Lys Leu Lys Phe Gly
5810 5815 5820
Thr Phe Gly Gly Leu Gly Ser Lys Ser Lys Gly His Tyr Glu Val
5825 5830 5835
Thr Gly Ser Asp Asp Glu Thr Gly Lys Leu Gln Gly Ser Gly Val
5840 5845 5850
Ser Leu Ala Ser Lys Lys Ser Arg Leu Ser Ser Ser Ser Ser Asn
5855 5860 5865
Asp Ser Gly Asn Lys Val Gly Ile Gln Leu Pro Glu Val Glu Leu
5870 5875 5880
Ser Val Ser Thr Lys Lys Glu
5885 5890
<210> 38
<211> 1894
<212> PRT
<213> 智人(Homo sapiens)
<400> 38
Met Ala Pro Glu Ala Gly Ala Thr Leu Arg Ala Pro Arg Arg Leu Ser
1 5 10 15
Trp Ala Ala Leu Leu Leu Leu Ala Ala Leu Leu Pro Val Ala Ser Ser
20 25 30
Ala Ala Ala Ser Val Asp His Pro Leu Lys Pro Arg His Val Lys Leu
35 40 45
Leu Ser Thr Lys Met Gly Leu Lys Val Thr Trp Asp Pro Pro Lys Asp
50 55 60
Ala Thr Ser Arg Pro Val Glu His Tyr Asn Ile Ala Tyr Gly Lys Ser
65 70 75 80
Leu Lys Ser Leu Lys Tyr Ile Lys Val Asn Ala Glu Thr Tyr Ser Phe
85 90 95
Leu Ile Glu Asp Val Glu Pro Gly Val Val Tyr Phe Val Leu Leu Thr
100 105 110
Ala Glu Asn His Ser Gly Val Ser Arg Pro Val Tyr Arg Ala Glu Ser
115 120 125
Pro Pro Gly Gly Glu Trp Ile Glu Ile Asp Gly Phe Pro Ile Lys Gly
130 135 140
Pro Gly Pro Phe Asn Glu Thr Val Thr Glu Lys Glu Val Pro Asn Lys
145 150 155 160
Pro Leu Arg Val Arg Val Arg Ser Ser Asp Asp Arg Leu Ser Val Ala
165 170 175
Trp Lys Ala Pro Arg Leu Ser Gly Ala Lys Ser Pro Arg Arg Ser Arg
180 185 190
Gly Phe Leu Leu Gly Tyr Gly Glu Ser Gly Arg Lys Met Asn Tyr Val
195 200 205
Pro Leu Thr Arg Asp Glu Arg Thr His Glu Ile Lys Lys Leu Ala Ser
210 215 220
Glu Ser Val Tyr Val Val Ser Leu Gln Ser Met Asn Ser Gln Gly Arg
225 230 235 240
Ser Gln Pro Val Tyr Arg Ala Ala Leu Thr Lys Arg Lys Ile Ser Glu
245 250 255
Glu Asp Glu Leu Asp Val Pro Asp Asp Ile Ser Val Arg Val Met Ser
260 265 270
Ser Gln Ser Val Leu Val Ser Trp Val Asp Pro Val Leu Glu Lys Gln
275 280 285
Lys Lys Val Val Ala Ser Arg Gln Tyr Thr Val Arg Tyr Arg Glu Lys
290 295 300
Gly Glu Leu Ala Arg Trp Asp Tyr Lys Gln Ile Ala Asn Arg Arg Val
305 310 315 320
Leu Ile Glu Asn Leu Ile Pro Asp Thr Val Tyr Glu Phe Ala Val Arg
325 330 335
Ile Ser Gln Gly Glu Arg Asp Gly Lys Trp Ser Thr Ser Val Phe Gln
340 345 350
Arg Thr Pro Glu Ser Ala Pro Thr Thr Ala Pro Glu Asn Leu Asn Val
355 360 365
Trp Pro Val Asn Gly Lys Pro Thr Val Val Ala Ala Ser Trp Asp Ala
370 375 380
Leu Pro Glu Thr Glu Gly Lys Val Lys Glu Tyr Ile Leu Ser Tyr Ala
385 390 395 400
Pro Ala Leu Lys Pro Phe Gly Ala Lys Ser Leu Thr Tyr Pro Gly Asp
405 410 415
Thr Thr Ser Ala Leu Val Asp Gly Leu Gln Pro Gly Glu Arg Tyr Leu
420 425 430
Phe Lys Ile Arg Ala Thr Asn Arg Arg Gly Leu Gly Pro His Ser Lys
435 440 445
Ala Phe Ile Val Ala Met Pro Thr Thr Ser Lys Ala Asp Val Glu Gln
450 455 460
Asn Thr Glu Asp Asn Gly Lys Pro Glu Lys Pro Glu Pro Ser Ser Pro
465 470 475 480
Ser Pro Arg Ala Pro Ala Ser Ser Gln His Pro Ser Val Pro Ala Ser
485 490 495
Pro Gln Gly Arg Asn Ala Lys Asp Leu Leu Leu Asp Leu Lys Asn Lys
500 505 510
Ile Leu Ala Asn Gly Gly Ala Pro Arg Lys Pro Gln Leu Arg Ala Lys
515 520 525
Lys Ala Glu Glu Leu Asp Leu Gln Ser Thr Glu Ile Thr Gly Glu Glu
530 535 540
Glu Leu Gly Ser Arg Glu Asp Ser Pro Met Ser Pro Ser Asp Thr Gln
545 550 555 560
Asp Gln Lys Arg Thr Leu Arg Pro Pro Ser Arg His Gly His Ser Val
565 570 575
Val Ala Pro Gly Arg Thr Ala Val Arg Ala Arg Met Pro Ala Leu Pro
580 585 590
Arg Arg Glu Gly Val Asp Lys Pro Gly Phe Ser Leu Ala Thr Gln Pro
595 600 605
Arg Pro Gly Ala Pro Pro Ser Ala Ser Ala Ser Pro Ala His His Ala
610 615 620
Ser Thr Gln Gly Thr Ser His Arg Pro Ser Leu Pro Ala Ser Leu Asn
625 630 635 640
Asp Asn Asp Leu Val Asp Ser Asp Glu Asp Glu Arg Ala Val Gly Ser
645 650 655
Leu His Pro Lys Gly Ala Phe Ala Gln Pro Arg Pro Ala Leu Ser Pro
660 665 670
Ser Arg Gln Ser Pro Ser Ser Val Leu Arg Asp Arg Ser Ser Val His
675 680 685
Pro Gly Ala Lys Pro Ala Ser Pro Ala Arg Arg Thr Pro His Ser Gly
690 695 700
Ala Ala Glu Glu Asp Ser Ser Ala Ser Ala Pro Pro Ser Arg Leu Ser
705 710 715 720
Pro Pro His Gly Gly Ser Ser Arg Leu Leu Pro Thr Gln Pro His Leu
725 730 735
Ser Ser Pro Leu Ser Lys Gly Gly Lys Asp Gly Glu Asp Ala Pro Ala
740 745 750
Thr Asn Ser Asn Ala Pro Ser Arg Ser Thr Met Ser Ser Ser Val Ser
755 760 765
Ser His Leu Ser Ser Arg Thr Gln Val Ser Glu Gly Ala Glu Ala Ser
770 775 780
Asp Gly Glu Ser His Gly Asp Gly Asp Arg Glu Asp Gly Gly Arg Gln
785 790 795 800
Ala Glu Ala Thr Ala Gln Thr Leu Arg Ala Arg Pro Ala Ser Gly His
805 810 815
Phe His Leu Leu Arg His Lys Pro Phe Ala Ala Asn Gly Arg Ser Pro
820 825 830
Ser Arg Phe Ser Ile Gly Arg Gly Pro Arg Leu Gln Pro Ser Ser Ser
835 840 845
Pro Gln Ser Thr Val Pro Ser Arg Ala His Pro Arg Val Pro Ser His
850 855 860
Ser Asp Ser His Pro Lys Leu Ser Ser Gly Ile His Gly Asp Glu Glu
865 870 875 880
Asp Glu Lys Pro Leu Pro Ala Thr Val Val Asn Asp His Val Pro Ser
885 890 895
Ser Ser Arg Gln Pro Ile Ser Arg Gly Trp Glu Asp Leu Arg Arg Ser
900 905 910
Pro Gln Arg Gly Ala Ser Leu His Arg Lys Glu Pro Ile Pro Glu Asn
915 920 925
Pro Lys Ser Thr Gly Ala Asp Thr His Pro Gln Gly Lys Tyr Ser Ser
930 935 940
Leu Ala Ser Lys Ala Gln Asp Val Gln Gln Ser Thr Asp Ala Asp Thr
945 950 955 960
Glu Gly His Ser Pro Lys Ala Gln Pro Gly Ser Thr Asp Arg His Ala
965 970 975
Ser Pro Ala Arg Pro Pro Ala Ala Arg Ser Gln Gln His Pro Ser Val
980 985 990
Pro Arg Arg Met Thr Pro Gly Arg Ala Pro Gln Gln Gln Pro Pro Pro
995 1000 1005
Pro Val Ala Thr Ser Gln His His Pro Gly Pro Gln Ser Arg Asp
1010 1015 1020
Ala Gly Arg Ser Pro Ser Gln Pro Arg Leu Ser Leu Thr Gln Ala
1025 1030 1035
Gly Arg Pro Arg Pro Thr Ser Gln Gly Arg Ser His Ser Ser Ser
1040 1045 1050
Asp Pro Tyr Thr Ala Ser Ser Arg Gly Met Leu Pro Thr Ala Leu
1055 1060 1065
Gln Asn Gln Asp Glu Asp Ala Gln Gly Ser Tyr Asp Asp Asp Ser
1070 1075 1080
Thr Glu Val Glu Ala Gln Asp Val Arg Ala Pro Ala His Ala Ala
1085 1090 1095
Arg Ala Lys Glu Ala Ala Ala Ser Leu Pro Lys His Gln Gln Val
1100 1105 1110
Glu Ser Pro Thr Gly Ala Gly Ala Gly Gly Asp His Arg Ser Gln
1115 1120 1125
Arg Gly His Ala Ala Ser Pro Ala Arg Pro Ser Arg Pro Gly Gly
1130 1135 1140
Pro Gln Ser Arg Ala Arg Val Pro Ser Arg Ala Ala Pro Gly Lys
1145 1150 1155
Ser Glu Pro Pro Ser Lys Arg Pro Leu Ser Ser Lys Ser Gln Gln
1160 1165 1170
Ser Val Ser Ala Glu Asp Asp Glu Glu Glu Asp Ala Gly Phe Phe
1175 1180 1185
Lys Gly Gly Lys Glu Asp Leu Leu Ser Ser Ser Val Pro Lys Trp
1190 1195 1200
Pro Ser Ser Ser Thr Pro Arg Gly Gly Lys Asp Ala Asp Gly Ser
1205 1210 1215
Leu Ala Lys Glu Glu Arg Glu Pro Ala Ile Ala Leu Ala Pro Arg
1220 1225 1230
Gly Gly Ser Leu Ala Pro Val Lys Arg Pro Leu Pro Pro Pro Pro
1235 1240 1245
Gly Ser Ser Pro Arg Ala Ser His Val Pro Ser Arg Leu Pro Pro
1250 1255 1260
Arg Ser Ala Ala Thr Val Ser Pro Val Ala Gly Thr His Pro Trp
1265 1270 1275
Pro Gln Tyr Thr Thr Arg Ala Pro Pro Gly His Phe Ser Thr Thr
1280 1285 1290
Pro Met Leu Ser Leu Arg Gln Arg Met Met His Ala Arg Phe Arg
1295 1300 1305
Asn Pro Leu Ser Arg Gln Pro Ala Arg Pro Ser Tyr Arg Gln Gly
1310 1315 1320
Tyr Asn Gly Arg Pro Asn Val Glu Gly Lys Val Leu Pro Gly Ser
1325 1330 1335
Asn Gly Lys Pro Asn Gly Gln Arg Ile Ile Asn Gly Pro Gln Gly
1340 1345 1350
Thr Lys Trp Val Val Asp Leu Asp Arg Gly Leu Val Leu Asn Ala
1355 1360 1365
Glu Gly Arg Tyr Leu Gln Asp Ser His Gly Asn Pro Leu Arg Ile
1370 1375 1380
Lys Leu Gly Gly Asp Gly Arg Thr Ile Val Asp Leu Glu Gly Thr
1385 1390 1395
Pro Val Val Ser Pro Asp Gly Leu Pro Leu Phe Gly Gln Gly Arg
1400 1405 1410
His Gly Thr Pro Leu Ala Asn Ala Gln Asp Lys Pro Ile Leu Ser
1415 1420 1425
Leu Gly Gly Lys Pro Leu Val Gly Leu Glu Val Ile Lys Lys Thr
1430 1435 1440
Thr His Pro Pro Thr Thr Thr Met Gln Pro Thr Thr Thr Thr Thr
1445 1450 1455
Pro Leu Pro Thr Thr Thr Thr Pro Arg Pro Thr Thr Ala Thr Thr
1460 1465 1470
Arg Arg Thr Thr Thr Thr Arg Arg Thr Thr Thr Arg Arg Pro Thr
1475 1480 1485
Thr Thr Val Arg Thr Thr Thr Arg Thr Thr Thr Thr Thr Thr Pro
1490 1495 1500
Thr Pro Thr Thr Pro Ile Pro Thr Cys Pro Pro Gly Thr Leu Glu
1505 1510 1515
Arg His Asp Asp Asp Gly Asn Leu Ile Met Ser Ser Asn Gly Ile
1520 1525 1530
Pro Glu Cys Tyr Ala Glu Glu Asp Glu Phe Ser Gly Leu Glu Thr
1535 1540 1545
Asp Thr Ala Val Pro Thr Glu Glu Ala Tyr Val Ile Tyr Asp Glu
1550 1555 1560
Asp Tyr Glu Phe Glu Thr Ser Arg Pro Pro Thr Thr Thr Glu Pro
1565 1570 1575
Ser Thr Thr Ala Thr Thr Pro Arg Val Ile Pro Glu Glu Gly Ala
1580 1585 1590
Ile Ser Ser Phe Pro Glu Glu Glu Phe Asp Leu Ala Gly Arg Lys
1595 1600 1605
Arg Phe Val Ala Pro Tyr Val Thr Tyr Leu Asn Lys Asp Pro Ser
1610 1615 1620
Ala Pro Cys Ser Leu Thr Asp Ala Leu Asp His Phe Gln Val Asp
1625 1630 1635
Ser Leu Asp Glu Ile Ile Pro Asn Asp Leu Lys Lys Ser Asp Leu
1640 1645 1650
Pro Pro Gln His Ala Pro Arg Asn Ile Thr Val Val Ala Val Glu
1655 1660 1665
Gly Cys His Ser Phe Val Ile Val Asp Trp Asp Lys Ala Thr Pro
1670 1675 1680
Gly Asp Val Val Thr Gly Tyr Leu Val Tyr Ser Ala Ser Tyr Glu
1685 1690 1695
Asp Phe Ile Arg Asn Lys Trp Ser Thr Gln Ala Ser Ser Val Thr
1700 1705 1710
His Leu Pro Ile Glu Asn Leu Lys Pro Asn Thr Arg Tyr Tyr Phe
1715 1720 1725
Lys Val Gln Ala Gln Asn Pro His Gly Tyr Gly Pro Ile Ser Pro
1730 1735 1740
Ser Val Ser Phe Val Thr Glu Ser Asp Asn Pro Leu Leu Val Val
1745 1750 1755
Arg Pro Pro Gly Gly Glu Pro Ile Trp Ile Pro Phe Ala Phe Lys
1760 1765 1770
His Asp Pro Ser Tyr Thr Asp Cys His Gly Arg Gln Tyr Val Lys
1775 1780 1785
Arg Thr Trp Tyr Arg Lys Phe Val Gly Val Val Leu Cys Asn Ser
1790 1795 1800
Leu Arg Tyr Lys Ile Tyr Leu Ser Asp Asn Leu Lys Asp Thr Phe
1805 1810 1815
Tyr Ser Ile Gly Asp Ser Trp Gly Arg Gly Glu Asp His Cys Gln
1820 1825 1830
Phe Val Asp Ser His Leu Asp Gly Arg Thr Gly Pro Gln Ser Tyr
1835 1840 1845
Val Glu Ala Leu Pro Thr Ile Gln Gly Tyr Tyr Arg Gln Tyr Arg
1850 1855 1860
Gln Glu Pro Val Arg Phe Gly Asn Ile Gly Phe Gly Thr Pro Tyr
1865 1870 1875
Tyr Tyr Val Gly Trp Tyr Glu Cys Gly Val Ser Ile Pro Gly Lys
1880 1885 1890
Trp
<210> 39
<211> 198
<212> PRT
<213> 智人(Homo sapiens)
<400> 39
Met Ala Ala Asp Ile Ser Glu Ser Ser Gly Ala Asp Cys Lys Gly Asp
1 5 10 15
Pro Arg Asn Ser Ala Lys Leu Asp Ala Asp Tyr Pro Leu Arg Val Leu
20 25 30
Tyr Cys Gly Val Cys Ser Leu Pro Thr Glu Tyr Cys Glu Tyr Met Pro
35 40 45
Asp Val Ala Lys Cys Arg Gln Trp Leu Glu Lys Asn Phe Pro Asn Glu
50 55 60
Phe Ala Lys Leu Thr Val Glu Asn Ser Pro Lys Gln Glu Ala Gly Ile
65 70 75 80
Ser Glu Gly Gln Gly Thr Ala Gly Glu Glu Glu Glu Lys Lys Lys Gln
85 90 95
Lys Arg Gly Gly Arg Gly Gln Ile Lys Gln Lys Lys Lys Thr Val Pro
100 105 110
Gln Lys Val Thr Ile Ala Lys Ile Pro Arg Ala Lys Lys Lys Tyr Val
115 120 125
Thr Arg Val Cys Gly Leu Ala Thr Phe Glu Ile Asp Leu Lys Glu Ala
130 135 140
Gln Arg Phe Phe Ala Gln Lys Phe Ser Cys Gly Ala Ser Val Thr Gly
145 150 155 160
Glu Asp Glu Ile Ile Ile Gln Gly Asp Phe Thr Asp Asp Ile Ile Asp
165 170 175
Val Ile Gln Glu Lys Trp Pro Glu Val Asp Asp Asp Ser Ile Glu Asp
180 185 190
Leu Gly Glu Val Lys Lys
195
<210> 40
<211> 267
<212> PRT
<213> 智人(Homo sapiens)
<400> 40
Met Ala Arg Phe Leu Thr Leu Cys Thr Trp Leu Leu Leu Leu Gly Pro
1 5 10 15
Gly Leu Leu Ala Thr Val Arg Ala Glu Cys Ser Gln Asp Cys Ala Thr
20 25 30
Cys Ser Tyr Arg Leu Val Arg Pro Ala Asp Ile Asn Phe Leu Ala Cys
35 40 45
Val Met Glu Cys Glu Gly Lys Leu Pro Ser Leu Lys Ile Trp Glu Thr
50 55 60
Cys Lys Glu Leu Leu Gln Leu Ser Lys Pro Glu Leu Pro Gln Asp Gly
65 70 75 80
Thr Ser Thr Leu Arg Glu Asn Ser Lys Pro Glu Glu Ser His Leu Leu
85 90 95
Ala Lys Arg Tyr Gly Gly Phe Met Lys Arg Tyr Gly Gly Phe Met Lys
100 105 110
Lys Met Asp Glu Leu Tyr Pro Met Glu Pro Glu Glu Glu Ala Asn Gly
115 120 125
Ser Glu Ile Leu Ala Lys Arg Tyr Gly Gly Phe Met Lys Lys Asp Ala
130 135 140
Glu Glu Asp Asp Ser Leu Ala Asn Ser Ser Asp Leu Leu Lys Glu Leu
145 150 155 160
Leu Glu Thr Gly Asp Asn Arg Glu Arg Ser His His Gln Asp Gly Ser
165 170 175
Asp Asn Glu Glu Glu Val Ser Lys Arg Tyr Gly Gly Phe Met Arg Gly
180 185 190
Leu Lys Arg Ser Pro Gln Leu Glu Asp Glu Ala Lys Glu Leu Gln Lys
195 200 205
Arg Tyr Gly Gly Phe Met Arg Arg Val Gly Arg Pro Glu Trp Trp Met
210 215 220
Asp Tyr Gln Lys Arg Tyr Gly Gly Phe Leu Lys Arg Phe Ala Glu Ala
225 230 235 240
Leu Pro Ser Asp Glu Glu Gly Glu Ser Tyr Ser Lys Glu Val Pro Glu
245 250 255
Met Glu Lys Arg Tyr Gly Gly Phe Met Arg Phe
260 265
<210> 41
<211> 105
<212> PRT
<213> 智人(Homo sapiens)
<400> 41
Met Ala Lys Ile Ser Ser Pro Thr Glu Thr Glu Arg Cys Ile Glu Ser
1 5 10 15
Leu Ile Ala Val Phe Gln Lys Tyr Ala Gly Lys Asp Gly Tyr Asn Tyr
20 25 30
Thr Leu Ser Lys Thr Glu Phe Leu Ser Phe Met Asn Thr Glu Leu Ala
35 40 45
Ala Phe Thr Lys Asn Gln Lys Asp Pro Gly Val Leu Asp Arg Met Met
50 55 60
Lys Lys Leu Asp Thr Asn Ser Asp Gly Gln Leu Asp Phe Ser Glu Phe
65 70 75 80
Leu Asn Leu Ile Gly Gly Leu Ala Met Ala Cys His Asp Ser Phe Leu
85 90 95
Lys Ala Val Pro Ser Gln Lys Arg Thr
100 105
<210> 42
<211> 159
<212> PRT
<213> 智人(Homo sapiens)
<400> 42
Met Ala Lys Ser Lys Asn His Thr Thr His Asn Gln Ser Arg Lys Trp
1 5 10 15
His Arg Asn Gly Ile Lys Lys Pro Arg Ser Gln Arg Tyr Glu Ser Leu
20 25 30
Lys Gly Val Asp Pro Lys Phe Leu Arg Asn Met Arg Phe Ala Lys Lys
35 40 45
His Asn Lys Lys Gly Leu Lys Lys Met Gln Ala Asn Asn Ala Lys Ala
50 55 60
Met Ser Ala Arg Ala Glu Ala Ile Lys Ala Leu Val Lys Pro Lys Glu
65 70 75 80
Val Lys Pro Lys Ile Pro Lys Gly Val Ser Arg Lys Leu Asp Arg Leu
85 90 95
Ala Tyr Ile Ala His Pro Lys Leu Gly Lys Arg Ala Arg Ala Arg Ile
100 105 110
Ala Lys Gly Leu Arg Leu Cys Arg Pro Lys Ala Lys Ala Lys Ala Lys
115 120 125
Ala Lys Asp Gln Thr Lys Ala Gln Ala Ala Ala Pro Ala Ser Val Pro
130 135 140
Ala Gln Ala Pro Lys Arg Thr Gln Ala Pro Thr Lys Ala Ser Glu
145 150 155
<210> 43
<211> 136
<212> PRT
<213> 智人(Homo sapiens)
<400> 43
Met Gly Lys Phe Met Lys Pro Gly Lys Val Val Leu Val Leu Ala Gly
1 5 10 15
Arg Tyr Ser Gly Arg Lys Ala Val Ile Val Lys Asn Ile Asp Asp Gly
20 25 30
Thr Ser Asp Arg Pro Tyr Ser His Ala Leu Val Ala Gly Ile Asp Arg
35 40 45
Tyr Pro Arg Lys Val Thr Ala Ala Met Gly Lys Lys Lys Ile Ala Lys
50 55 60
Arg Ser Lys Ile Lys Ser Phe Val Lys Val Tyr Asn Tyr Asn His Leu
65 70 75 80
Met Pro Thr Arg Tyr Ser Val Asp Ile Pro Leu Asp Lys Thr Val Val
85 90 95
Asn Lys Asp Val Phe Arg Asp Pro Ala Leu Lys Arg Lys Ala Arg Arg
100 105 110
Glu Ala Lys Val Lys Phe Glu Glu Arg Tyr Lys Thr Gly Lys Asn Lys
115 120 125
Trp Phe Phe Gln Lys Leu Arg Phe
130 135
<210> 44
<211> 257
<212> PRT
<213> 智人(Homo sapiens)
<400> 44
Met Gly Arg Val Ile Arg Gly Gln Arg Lys Gly Ala Gly Ser Val Phe
1 5 10 15
Arg Ala His Val Lys His Arg Lys Gly Ala Ala Arg Leu Arg Ala Val
20 25 30
Asp Phe Ala Glu Arg His Gly Tyr Ile Lys Gly Ile Val Lys Asp Ile
35 40 45
Ile His Asp Pro Gly Arg Gly Ala Pro Leu Ala Lys Val Val Phe Arg
50 55 60
Asp Pro Tyr Arg Phe Lys Lys Arg Thr Glu Leu Phe Ile Ala Ala Glu
65 70 75 80
Gly Ile His Thr Gly Gln Phe Val Tyr Cys Gly Lys Lys Ala Gln Leu
85 90 95
Asn Ile Gly Asn Val Leu Pro Val Gly Thr Met Pro Glu Gly Thr Ile
100 105 110
Val Cys Cys Leu Glu Glu Lys Pro Gly Asp Arg Gly Lys Leu Ala Arg
115 120 125
Ala Ser Gly Asn Tyr Ala Thr Val Ile Ser His Asn Pro Glu Thr Lys
130 135 140
Lys Thr Arg Val Lys Leu Pro Ser Gly Ser Lys Lys Val Ile Ser Ser
145 150 155 160
Ala Asn Arg Ala Val Val Gly Val Val Ala Gly Gly Gly Arg Ile Asp
165 170 175
Lys Pro Ile Leu Lys Ala Gly Arg Ala Tyr His Lys Tyr Lys Ala Lys
180 185 190
Arg Asn Cys Trp Pro Arg Val Arg Gly Val Ala Met Asn Pro Val Glu
195 200 205
His Pro Phe Gly Gly Gly Asn His Gln His Ile Gly Lys Pro Ser Thr
210 215 220
Ile Arg Arg Asp Ala Pro Ala Gly Arg Lys Val Gly Leu Ile Ala Ala
225 230 235 240
Arg Arg Thr Gly Arg Leu Arg Gly Thr Lys Thr Val Gln Glu Lys Glu
245 250 255
Asn
<210> 45
<211> 221
<212> PRT
<213> 智人(Homo sapiens)
<400> 45
Met Ser Tyr Gly Arg Pro Pro Pro Asp Val Glu Gly Met Thr Ser Leu
1 5 10 15
Lys Val Asp Asn Leu Thr Tyr Arg Thr Ser Pro Asp Thr Leu Arg Arg
20 25 30
Val Phe Glu Lys Tyr Gly Arg Val Gly Asp Val Tyr Ile Pro Arg Asp
35 40 45
Arg Tyr Thr Lys Glu Ser Arg Gly Phe Ala Phe Val Arg Phe His Asp
50 55 60
Lys Arg Asp Ala Glu Asp Ala Met Asp Ala Met Asp Gly Ala Val Leu
65 70 75 80
Asp Gly Arg Glu Leu Arg Val Gln Met Ala Arg Tyr Gly Arg Pro Pro
85 90 95
Asp Ser His His Ser Arg Arg Gly Pro Pro Pro Arg Arg Tyr Gly Gly
100 105 110
Gly Gly Tyr Gly Arg Arg Ser Arg Ser Pro Arg Arg Arg Arg Arg Ser
115 120 125
Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Tyr
130 135 140
Ser Arg Ser Lys Ser Arg Ser Arg Thr Arg Ser Arg Ser Arg Ser Thr
145 150 155 160
Ser Lys Ser Arg Ser Ala Arg Arg Ser Lys Ser Lys Ser Ser Ser Val
165 170 175
Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Pro
180 185 190
Pro Pro Val Ser Lys Arg Glu Ser Lys Ser Arg Ser Arg Ser Lys Ser
195 200 205
Pro Pro Lys Ser Pro Glu Glu Glu Gly Ala Val Ser Ser
210 215 220
<210> 46
<211> 424
<212> PRT
<213> 智人(Homo sapiens)
<400> 46
Met Ala Ala Gly Pro Ile Ser Glu Arg Asn Gln Asp Ala Thr Val Tyr
1 5 10 15
Val Gly Gly Leu Asp Glu Lys Val Ser Glu Pro Leu Leu Trp Glu Leu
20 25 30
Phe Leu Gln Ala Gly Pro Val Val Asn Thr His Met Pro Lys Asp Arg
35 40 45
Val Thr Gly Gln His Gln Gly Tyr Gly Phe Val Glu Phe Leu Ser Glu
50 55 60
Glu Asp Ala Asp Tyr Ala Ile Lys Ile Met Asn Met Ile Lys Leu Tyr
65 70 75 80
Gly Lys Pro Ile Arg Val Asn Lys Ala Ser Ala His Asn Lys Asn Leu
85 90 95
Asp Val Gly Ala Asn Ile Phe Ile Gly Asn Leu Asp Pro Glu Ile Asp
100 105 110
Glu Lys Leu Leu Tyr Asp Thr Phe Ser Ala Phe Gly Val Ile Leu Gln
115 120 125
Thr Pro Lys Ile Met Arg Asp Pro Asp Thr Gly Asn Ser Lys Gly Tyr
130 135 140
Ala Phe Ile Asn Phe Ala Ser Phe Asp Ala Ser Asp Ala Ala Ile Glu
145 150 155 160
Ala Met Asn Gly Gln Tyr Leu Cys Asn Arg Pro Ile Thr Val Ser Tyr
165 170 175
Ala Phe Lys Lys Asp Ser Lys Gly Glu Arg His Gly Ser Ala Ala Glu
180 185 190
Arg Leu Leu Ala Ala Gln Asn Pro Leu Ser Gln Ala Asp Arg Pro His
195 200 205
Gln Leu Phe Ala Asp Ala Pro Pro Pro Pro Ser Ala Pro Asn Pro Val
210 215 220
Val Ser Ser Leu Gly Ser Gly Leu Pro Pro Pro Gly Met Pro Pro Pro
225 230 235 240
Gly Ser Phe Pro Pro Pro Val Pro Pro Pro Gly Ala Leu Pro Pro Gly
245 250 255
Ile Pro Pro Ala Met Pro Pro Pro Pro Met Pro Pro Gly Ala Ala Gly
260 265 270
His Gly Pro Pro Ser Ala Gly Thr Pro Gly Ala Gly His Pro Gly His
275 280 285
Gly His Ser His Pro His Pro Phe Pro Pro Gly Gly Met Pro His Pro
290 295 300
Gly Met Ser Gln Met Gln Leu Ala His His Gly Pro His Gly Leu Gly
305 310 315 320
His Pro His Ala Gly Pro Pro Gly Ser Gly Gly Gln Pro Pro Pro Arg
325 330 335
Pro Pro Pro Gly Met Pro His Pro Gly Pro Pro Pro Met Gly Met Pro
340 345 350
Pro Arg Gly Pro Pro Phe Gly Ser Pro Met Gly His Pro Gly Pro Met
355 360 365
Pro Pro His Gly Met Arg Gly Pro Pro Pro Leu Met Pro Pro His Gly
370 375 380
Tyr Thr Gly Pro Pro Arg Pro Pro Pro Tyr Gly Tyr Gln Arg Gly Pro
385 390 395 400
Leu Pro Pro Pro Arg Pro Thr Pro Arg Pro Pro Val Pro Pro Arg Gly
405 410 415
Pro Leu Arg Gly Pro Leu Pro Gln
420
<210> 47
<211> 590
<212> PRT
<213> 智人(Homo sapiens)
<400> 47
Met His Leu Ala Arg Leu Val Gly Ser Cys Ser Leu Leu Leu Leu Leu
1 5 10 15
Gly Ala Leu Ser Gly Trp Ala Ala Ser Asp Asp Pro Ile Glu Lys Val
20 25 30
Ile Glu Gly Ile Asn Arg Gly Leu Ser Asn Ala Glu Arg Glu Val Gly
35 40 45
Lys Ala Leu Asp Gly Ile Asn Ser Gly Ile Thr His Ala Gly Arg Glu
50 55 60
Val Glu Lys Val Phe Asn Gly Leu Ser Asn Met Gly Ser His Thr Gly
65 70 75 80
Lys Glu Leu Asp Lys Gly Val Gln Gly Leu Asn His Gly Met Asp Lys
85 90 95
Val Ala His Glu Ile Asn His Gly Ile Gly Gln Ala Gly Lys Glu Ala
100 105 110
Glu Lys Leu Gly His Gly Val Asn Asn Ala Ala Gly Gln Val Gly Lys
115 120 125
Glu Ala Asp Lys Leu Ile His His Gly Val His His Gly Ala Asn Gln
130 135 140
Ala Gly Ser Glu Ala Gly Lys Phe Gly Gln Gly Val Asp Asn Ala Ala
145 150 155 160
Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln Gly Val His His
165 170 175
Ala Ala Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln Gly Val
180 185 190
His His Ala Ala Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln
195 200 205
Gly Ala His His Gly Leu Ser Glu Gly Trp Lys Glu Thr Glu Lys Phe
210 215 220
Gly Gln Gly Ile His His Ala Ala Gly Gln Val Gly Lys Glu Ala Glu
225 230 235 240
Lys Phe Gly Gln Gly Ala His His Ala Ala Gly Gln Ala Gly Asn Glu
245 250 255
Ala Gly Arg Phe Gly Gln Gly Val His His Gly Leu Ser Glu Gly Trp
260 265 270
Lys Glu Thr Glu Lys Phe Gly Gln Gly Val His His Thr Ala Gly Gln
275 280 285
Val Gly Lys Glu Ala Glu Lys Phe Gly Gln Gly Ala His His Ala Ala
290 295 300
Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln Gly Ala His His
305 310 315 320
Ala Ala Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln Gly Val
325 330 335
His His Gly Leu Ser Glu Gly Trp Lys Glu Thr Glu Lys Phe Gly Gln
340 345 350
Gly Val His His Ala Ala Ser Gln Phe Gly Lys Glu Thr Glu Lys Leu
355 360 365
Gly His Gly Val His His Gly Val Asn Glu Ala Trp Lys Glu Ala Glu
370 375 380
Lys Phe Gly Gln Gly Val His His Ala Ala Ser Gln Val Gly Lys Glu
385 390 395 400
Glu Asp Arg Val Val Gln Gly Leu His His Gly Val Ser Gln Ala Gly
405 410 415
Arg Glu Ala Gly Gln Phe Gly His Asp Ile His His Thr Ala Gly Gln
420 425 430
Ala Gly Lys Glu Gly Asp Ile Ala Val His Gly Val Gln Pro Gly Val
435 440 445
His Glu Ala Gly Lys Glu Ala Gly Gln Phe Gly Gln Gly Val His His
450 455 460
Thr Leu Glu Gln Ala Gly Lys Glu Ala Asp Lys Ala Val Gln Gly Phe
465 470 475 480
His Thr Gly Val His Gln Ala Gly Lys Glu Ala Glu Lys Leu Gly Gln
485 490 495
Gly Val Asn His Ala Ala Asp Gln Ala Gly Lys Glu Val Glu Lys Leu
500 505 510
Gly Gln Gly Ala His His Ala Ala Gly Gln Ala Gly Lys Glu Leu Gln
515 520 525
Asn Ala His Asn Gly Val Asn Gln Ala Ser Lys Glu Ala Asn Gln Leu
530 535 540
Leu Asn Gly Asn His Gln Ser Gly Ser Ser Ser His Gln Gly Gly Ala
545 550 555 560
Thr Thr Thr Pro Leu Ala Ser Gly Ala Ser Val Asn Thr Pro Phe Ile
565 570 575
Asn Leu Pro Ala Leu Trp Arg Ser Val Ala Asn Ile Met Pro
580 585 590
<210> 48
<211> 379
<212> PRT
<213> 智人(Homo sapiens)
<400> 48
Met Val Phe Phe Thr Cys Asn Ala Cys Gly Glu Ser Val Lys Lys Ile
1 5 10 15
Gln Val Glu Lys His Val Ser Val Cys Arg Asn Cys Glu Cys Leu Ser
20 25 30
Cys Ile Asp Cys Gly Lys Asp Phe Trp Gly Asp Asp Tyr Lys Asn His
35 40 45
Val Lys Cys Ile Ser Glu Asp Gln Lys Tyr Gly Gly Lys Gly Tyr Glu
50 55 60
Gly Lys Thr His Lys Gly Asp Ile Lys Gln Gln Ala Trp Ile Gln Lys
65 70 75 80
Ile Ser Glu Leu Ile Lys Arg Pro Asn Val Ser Pro Lys Val Arg Glu
85 90 95
Leu Leu Glu Gln Ile Ser Ala Phe Asp Asn Val Pro Arg Lys Lys Ala
100 105 110
Lys Phe Gln Asn Trp Met Lys Asn Ser Leu Lys Val His Asn Glu Ser
115 120 125
Ile Leu Asp Gln Val Trp Asn Ile Phe Ser Glu Ala Ser Asn Ser Glu
130 135 140
Pro Val Asn Lys Glu Gln Asp Gln Arg Pro Leu His Pro Val Ala Asn
145 150 155 160
Pro His Ala Glu Ile Ser Thr Lys Val Pro Ala Ser Lys Val Lys Asp
165 170 175
Ala Val Glu Gln Gln Gly Glu Val Lys Lys Asn Lys Arg Glu Arg Lys
180 185 190
Glu Glu Arg Gln Lys Lys Arg Lys Arg Glu Lys Lys Glu Leu Lys Leu
195 200 205
Glu Asn His Gln Glu Asn Ser Arg Asn Gln Lys Pro Lys Lys Arg Lys
210 215 220
Lys Gly Gln Glu Ala Asp Leu Glu Ala Gly Gly Glu Glu Val Pro Glu
225 230 235 240
Ala Asn Gly Ser Ala Gly Lys Arg Ser Lys Lys Lys Lys Gln Arg Lys
245 250 255
Asp Ser Ala Ser Glu Glu Glu Ala His Val Gly Ala Gly Lys Arg Lys
260 265 270
Arg Arg His Ser Glu Val Glu Thr Asp Ser Lys Lys Lys Lys Met Lys
275 280 285
Leu Pro Glu His Pro Glu Gly Gly Glu Pro Glu Asp Asp Glu Ala Pro
290 295 300
Ala Lys Gly Lys Phe Asn Trp Lys Gly Thr Ile Lys Ala Ile Leu Lys
305 310 315 320
Gln Ala Pro Asp Asn Glu Ile Thr Ile Lys Lys Leu Arg Lys Lys Val
325 330 335
Leu Ala Gln Tyr Tyr Thr Val Thr Asp Glu His His Arg Ser Glu Glu
340 345 350
Glu Leu Leu Val Ile Phe Asn Lys Lys Ile Ser Lys Asn Pro Thr Phe
355 360 365
Lys Leu Leu Lys Asp Lys Val Lys Leu Val Lys
370 375
<210> 49
<211> 331
<212> PRT
<213> 智人(Homo sapiens)
<400> 49
Met Gly Gly Glu Gln Glu Glu Glu Arg Phe Asp Gly Met Leu Leu Ala
1 5 10 15
Met Ala Gln Gln His Glu Gly Gly Val Gln Glu Leu Val Asn Thr Phe
20 25 30
Phe Ser Phe Leu Arg Arg Lys Thr Asp Phe Phe Ile Gly Gly Glu Glu
35 40 45
Gly Met Ala Glu Lys Leu Ile Thr Gln Thr Phe Ser His His Asn Gln
50 55 60
Leu Ala Gln Lys Thr Arg Arg Glu Lys Arg Ala Arg Gln Glu Ala Glu
65 70 75 80
Arg Arg Glu Lys Ala Glu Arg Ala Ala Arg Leu Ala Lys Glu Ala Lys
85 90 95
Ser Glu Thr Ser Gly Pro Gln Ile Lys Glu Leu Thr Asp Glu Glu Ala
100 105 110
Glu Arg Leu Gln Leu Glu Ile Asp Gln Lys Lys Asp Ala Glu Asn His
115 120 125
Glu Ala Gln Leu Lys Asn Gly Ser Leu Asp Ser Pro Gly Lys Gln Asp
130 135 140
Thr Glu Glu Asp Glu Glu Glu Asp Glu Lys Asp Lys Gly Lys Leu Lys
145 150 155 160
Pro Asn Leu Gly Asn Gly Ala Asp Leu Pro Asn Tyr Arg Trp Thr Gln
165 170 175
Thr Leu Ser Glu Leu Asp Leu Ala Val Pro Phe Cys Val Asn Phe Arg
180 185 190
Leu Lys Gly Lys Asp Met Val Val Asp Ile Gln Arg Arg His Leu Arg
195 200 205
Val Gly Leu Lys Gly Gln Pro Ala Ile Ile Asp Gly Glu Leu Tyr Asn
210 215 220
Glu Val Lys Val Glu Glu Ser Ser Trp Leu Ile Glu Asp Gly Lys Val
225 230 235 240
Val Thr Val His Leu Glu Lys Ile Asn Lys Met Glu Trp Trp Ser Arg
245 250 255
Leu Val Ser Ser Asp Pro Glu Ile Asn Thr Lys Lys Ile Asn Pro Glu
260 265 270
Asn Ser Lys Leu Ser Asp Leu Asp Ser Glu Thr Arg Ser Met Val Glu
275 280 285
Lys Met Met Tyr Asp Gln Arg Gln Lys Ser Met Gly Leu Pro Thr Ser
290 295 300
Asp Glu Gln Lys Lys Gln Glu Ile Leu Lys Lys Phe Met Asp Gln His
305 310 315 320
Pro Glu Met Asp Phe Ser Lys Ala Lys Phe Asn
325 330
<210> 50
<211> 422
<212> PRT
<213> 智人(Homo sapiens)
<400> 50
Met Pro Ala Gly Arg Arg Gly Pro Ala Ala Gln Ser Ala Arg Arg Pro
1 5 10 15
Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu Cys Val Leu Gly Ala Pro
20 25 30
Arg Ala Gly Ser Gly Ala His Thr Ala Val Ile Ser Pro Gln Asp Pro
35 40 45
Thr Leu Leu Ile Gly Ser Ser Leu Leu Ala Thr Cys Ser Val His Gly
50 55 60
Asp Pro Pro Gly Ala Thr Ala Glu Gly Leu Tyr Trp Thr Leu Asn Gly
65 70 75 80
Arg Arg Leu Pro Pro Glu Leu Ser Arg Val Leu Asn Ala Ser Thr Leu
85 90 95
Ala Leu Ala Leu Ala Asn Leu Asn Gly Ser Arg Gln Arg Ser Gly Asp
100 105 110
Asn Leu Val Cys His Ala Arg Asp Gly Ser Ile Leu Ala Gly Ser Cys
115 120 125
Leu Tyr Val Gly Leu Pro Pro Glu Lys Pro Val Asn Ile Ser Cys Trp
130 135 140
Ser Lys Asn Met Lys Asp Leu Thr Cys Arg Trp Thr Pro Gly Ala His
145 150 155 160
Gly Glu Thr Phe Leu His Thr Asn Tyr Ser Leu Lys Tyr Lys Leu Arg
165 170 175
Trp Tyr Gly Gln Asp Asn Thr Cys Glu Glu Tyr His Thr Val Gly Pro
180 185 190
His Ser Cys His Ile Pro Lys Asp Leu Ala Leu Phe Thr Pro Tyr Glu
195 200 205
Ile Trp Val Glu Ala Thr Asn Arg Leu Gly Ser Ala Arg Ser Asp Val
210 215 220
Leu Thr Leu Asp Ile Leu Asp Val Val Thr Thr Asp Pro Pro Pro Asp
225 230 235 240
Val His Val Ser Arg Val Gly Gly Leu Glu Asp Gln Leu Ser Val Arg
245 250 255
Trp Val Ser Pro Pro Ala Leu Lys Asp Phe Leu Phe Gln Ala Lys Tyr
260 265 270
Gln Ile Arg Tyr Arg Val Glu Asp Ser Val Asp Trp Lys Val Val Asp
275 280 285
Asp Val Ser Asn Gln Thr Ser Cys Arg Leu Ala Gly Leu Lys Pro Gly
290 295 300
Thr Val Tyr Phe Val Gln Val Arg Cys Asn Pro Phe Gly Ile Tyr Gly
305 310 315 320
Ser Lys Lys Ala Gly Ile Trp Ser Glu Trp Ser His Pro Thr Ala Ala
325 330 335
Ser Thr Pro Arg Ser Glu Arg Pro Gly Pro Gly Gly Gly Ala Cys Glu
340 345 350
Pro Arg Gly Gly Glu Pro Ser Ser Gly Pro Val Arg Arg Glu Leu Lys
355 360 365
Gln Phe Leu Gly Trp Leu Lys Lys His Ala Tyr Cys Ser Asn Leu Ser
370 375 380
Phe Arg Leu Tyr Asp Gln Trp Arg Ala Trp Met Gln Lys Ser His Lys
385 390 395 400
Thr Arg Asn Gln Asp Glu Gly Ile Leu Pro Ser Gly Arg Arg Gly Thr
405 410 415
Ala Arg Gly Pro Ala Arg
420
<210> 51
<211> 390
<212> PRT
<213> 智人(Homo sapiens)
<400> 51
Met Pro Pro Ser Gly Leu Arg Leu Leu Leu Leu Leu Leu Pro Leu Leu
1 5 10 15
Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr
20 25 30
Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala
35 40 45
Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser
50 55 60
Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu
65 70 75 80
Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu
85 90 95
Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu
100 105 110
Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr
115 120 125
His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val
130 135 140
Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu
145 150 155 160
Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn
165 170 175
Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser
180 185 190
Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu
195 200 205
Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser
210 215 220
Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr
225 230 235 240
Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro
245 250 255
Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln
260 265 270
Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser
275 280 285
Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys
290 295 300
Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn
305 310 315 320
Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr
325 330 335
Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala
340 345 350
Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr
355 360 365
Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val
370 375 380
Arg Ser Cys Lys Cys Ser
385 390
<210> 52
<211> 527
<212> PRT
<213> 智人(Homo sapiens)
<400> 52
Met Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Gln His Trp Lys
1 5 10 15
Glu Gln Arg Ala Ala Gln Lys Ala Asp Val Leu Thr Thr Gly Ala Gly
20 25 30
Asn Pro Val Gly Asp Lys Leu Asn Val Ile Thr Val Gly Pro Arg Gly
35 40 45
Pro Leu Leu Val Gln Asp Val Val Phe Thr Asp Glu Met Ala His Phe
50 55 60
Asp Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly
65 70 75 80
Ala Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Lys Tyr Ser Lys
85 90 95
Ala Lys Val Phe Glu His Ile Gly Lys Lys Thr Pro Ile Ala Val Arg
100 105 110
Phe Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp
115 120 125
Pro Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp
130 135 140
Leu Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Pro Ile Leu
145 150 155 160
Phe Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu
165 170 175
Lys Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Arg Pro Glu Ser
180 185 190
Leu His Gln Val Ser Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly
195 200 205
His Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn
210 215 220
Ala Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Asp Gln
225 230 235 240
Gly Ile Lys Asn Leu Ser Val Glu Asp Ala Ala Arg Leu Ser Gln Glu
245 250 255
Asp Pro Asp Tyr Gly Ile Arg Asp Leu Phe Asn Ala Ile Ala Thr Gly
260 265 270
Lys Tyr Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Asn Gln
275 280 285
Ala Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Lys Val Trp Pro
290 295 300
His Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg
305 310 315 320
Asn Pro Val Asn Tyr Phe Ala Glu Val Glu Gln Ile Ala Phe Asp Pro
325 330 335
Ser Asn Met Pro Pro Gly Ile Glu Ala Ser Pro Asp Lys Met Leu Gln
340 345 350
Gly Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro
355 360 365
Asn Tyr Leu His Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala
370 375 380
Asn Tyr Gln Arg Asp Gly Pro Met Cys Met Gln Asp Asn Gln Gly Gly
385 390 395 400
Ala Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln Gln Pro
405 410 415
Ser Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg Arg Phe
420 425 430
Asn Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala Phe Tyr Val
435 440 445
Asn Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn Ile Ala
450 455 460
Gly His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala Val Lys
465 470 475 480
Asn Phe Thr Glu Val His Pro Asp Tyr Gly Ser His Ile Gln Ala Leu
485 490 495
Leu Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His Thr Phe
500 505 510
Val Gln Ser Gly Ser His Leu Ala Ala Arg Glu Lys Ala Asn Leu
515 520 525
<210> 53
<211> 412
<212> PRT
<213> 智人(Homo sapiens)
<400> 53
Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala
1 5 10 15
Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile
20 25 30
Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala
35 40 45
Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu
50 55 60
Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr
65 70 75 80
Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe
85 90 95
Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu
100 105 110
Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser
115 120 125
Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser
130 135 140
Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys
145 150 155 160
Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg
165 170 175
Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala
180 185 190
Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val
195 200 205
Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val
210 215 220
Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln
225 230 235 240
Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys
245 250 255
Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val
260 265 270
His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu
275 280 285
Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro
290 295 300
Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu
305 310 315 320
Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro
325 330 335
Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu
340 345 350
Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser
355 360 365
Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile
370 375 380
Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp
385 390 395 400
Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu
405 410
<210> 54
<211> 509
<212> PRT
<213> 智人(Homo sapiens)
<400> 54
Met Gln Ser Trp Ser Arg Val Tyr Cys Ser Leu Ala Lys Arg Gly His
1 5 10 15
Phe Asn Arg Ile Ser His Gly Leu Gln Gly Leu Ser Ala Val Pro Leu
20 25 30
Arg Thr Tyr Ala Asp Gln Pro Ile Asp Ala Asp Val Thr Val Ile Gly
35 40 45
Ser Gly Pro Gly Gly Tyr Val Ala Ala Ile Lys Ala Ala Gln Leu Gly
50 55 60
Phe Lys Thr Val Cys Ile Glu Lys Asn Glu Thr Leu Gly Gly Thr Cys
65 70 75 80
Leu Asn Val Gly Cys Ile Pro Ser Lys Ala Leu Leu Asn Asn Ser His
85 90 95
Tyr Tyr His Met Ala His Gly Lys Asp Phe Ala Ser Arg Gly Ile Glu
100 105 110
Met Ser Glu Val Arg Leu Asn Leu Asp Lys Met Met Glu Gln Lys Ser
115 120 125
Thr Ala Val Lys Ala Leu Thr Gly Gly Ile Ala His Leu Phe Lys Gln
130 135 140
Asn Lys Val Val His Val Asn Gly Tyr Gly Lys Ile Thr Gly Lys Asn
145 150 155 160
Gln Val Thr Ala Thr Lys Ala Asp Gly Gly Thr Gln Val Ile Asp Thr
165 170 175
Lys Asn Ile Leu Ile Ala Thr Gly Ser Glu Val Thr Pro Phe Pro Gly
180 185 190
Ile Thr Ile Asp Glu Asp Thr Ile Val Ser Ser Thr Gly Ala Leu Ser
195 200 205
Leu Lys Lys Val Pro Glu Lys Met Val Val Ile Gly Ala Gly Val Ile
210 215 220
Gly Val Glu Leu Gly Ser Val Trp Gln Arg Leu Gly Ala Asp Val Thr
225 230 235 240
Ala Val Glu Phe Leu Gly His Val Gly Gly Val Gly Ile Asp Met Glu
245 250 255
Ile Ser Lys Asn Phe Gln Arg Ile Leu Gln Lys Gln Gly Phe Lys Phe
260 265 270
Lys Leu Asn Thr Lys Val Thr Gly Ala Thr Lys Lys Ser Asp Gly Lys
275 280 285
Ile Asp Val Ser Ile Glu Ala Ala Ser Gly Gly Lys Ala Glu Val Ile
290 295 300
Thr Cys Asp Val Leu Leu Val Cys Ile Gly Arg Arg Pro Phe Thr Lys
305 310 315 320
Asn Leu Gly Leu Glu Glu Leu Gly Ile Glu Leu Asp Pro Arg Gly Arg
325 330 335
Ile Pro Val Asn Thr Arg Phe Gln Thr Lys Ile Pro Asn Ile Tyr Ala
340 345 350
Ile Gly Asp Val Val Ala Gly Pro Met Leu Ala His Lys Ala Glu Asp
355 360 365
Glu Gly Ile Ile Cys Val Glu Gly Met Ala Gly Gly Ala Val His Ile
370 375 380
Asp Tyr Asn Cys Val Pro Ser Val Ile Tyr Thr His Pro Glu Val Ala
385 390 395 400
Trp Val Gly Lys Ser Glu Glu Gln Leu Lys Glu Glu Gly Ile Glu Tyr
405 410 415
Lys Val Gly Lys Phe Pro Phe Ala Ala Asn Ser Arg Ala Lys Thr Asn
420 425 430
Ala Asp Thr Asp Gly Met Val Lys Ile Leu Gly Gln Lys Ser Thr Asp
435 440 445
Arg Val Leu Gly Ala His Ile Leu Gly Pro Gly Ala Gly Glu Met Val
450 455 460
Asn Glu Ala Ala Leu Ala Leu Glu Tyr Gly Ala Ser Cys Glu Asp Ile
465 470 475 480
Ala Arg Val Cys His Ala His Pro Thr Leu Ser Glu Ala Phe Arg Glu
485 490 495
Ala Asn Leu Ala Ala Ser Phe Gly Lys Ser Ile Asn Phe
500 505
<210> 55
<211> 1005
<212> PRT
<213> 智人(Homo sapiens)
<400> 55
Met Thr Thr Glu Val Gly Ser Val Ser Glu Val Lys Lys Asp Ser Ser
1 5 10 15
Gln Leu Gly Thr Asp Ala Thr Lys Glu Lys Pro Lys Glu Val Ala Glu
20 25 30
Asn Gln Gln Asn Gln Ser Ser Asp Pro Glu Glu Glu Lys Gly Ser Gln
35 40 45
Pro Pro Pro Ala Ala Glu Ser Gln Ser Ser Leu Arg Arg Gln Lys Arg
50 55 60
Glu Lys Glu Thr Ser Glu Ser Arg Gly Ile Ser Arg Phe Ile Pro Pro
65 70 75 80
Trp Leu Lys Lys Gln Lys Ser Tyr Thr Leu Val Val Ala Lys Asp Gly
85 90 95
Gly Asp Lys Lys Glu Pro Thr Gln Ala Val Val Glu Glu Gln Val Leu
100 105 110
Asp Lys Glu Glu Pro Leu Pro Glu Glu Gln Arg Gln Ala Lys Gly Asp
115 120 125
Ala Glu Glu Met Ala Gln Lys Lys Gln Glu Ile Lys Val Glu Val Lys
130 135 140
Glu Glu Lys Pro Ser Val Ser Lys Glu Glu Lys Pro Ser Val Ser Lys
145 150 155 160
Val Glu Met Gln Pro Thr Glu Leu Val Ser Lys Glu Arg Glu Glu Lys
165 170 175
Val Lys Glu Thr Gln Glu Asp Lys Leu Glu Gly Gly Ala Ala Lys Arg
180 185 190
Glu Thr Lys Glu Val Gln Thr Asn Glu Leu Lys Ala Glu Lys Ala Ser
195 200 205
Gln Lys Val Thr Lys Lys Thr Lys Thr Val Gln Cys Lys Val Thr Leu
210 215 220
Leu Asp Gly Thr Glu Tyr Ser Cys Asp Leu Glu Lys His Ala Lys Gly
225 230 235 240
Gln Val Leu Phe Asp Lys Val Cys Glu His Leu Asn Leu Leu Glu Lys
245 250 255
Asp Tyr Phe Gly Leu Leu Phe Gln Glu Ser Pro Glu Gln Lys Asn Trp
260 265 270
Leu Asp Pro Ala Lys Glu Ile Lys Arg Gln Leu Arg Asn Leu Pro Trp
275 280 285
Leu Phe Thr Phe Asn Val Lys Phe Tyr Pro Pro Asp Pro Ser Gln Leu
290 295 300
Thr Glu Asp Ile Thr Arg Tyr Phe Leu Cys Leu Gln Leu Arg Gln Asp
305 310 315 320
Ile Ala Ser Gly Arg Leu Pro Cys Ser Phe Val Thr His Ala Leu Leu
325 330 335
Gly Ser Tyr Thr Leu Gln Ala Glu Leu Gly Asp Tyr Asp Pro Glu Glu
340 345 350
His Gly Ser Ile Asp Leu Ser Glu Phe Gln Phe Ala Pro Thr Gln Thr
355 360 365
Lys Glu Leu Glu Glu Lys Val Ala Glu Leu His Lys Thr His Arg Gly
370 375 380
Leu Ser Pro Ala Gln Ala Asp Ser Gln Phe Leu Glu Asn Ala Lys Arg
385 390 395 400
Leu Ser Met Tyr Gly Val Asp Leu His His Ala Lys Asp Ser Glu Gly
405 410 415
Val Asp Ile Lys Leu Gly Val Cys Ala Asn Gly Leu Leu Ile Tyr Lys
420 425 430
Asp Arg Leu Arg Ile Asn Arg Phe Ala Trp Pro Lys Ile Leu Lys Ile
435 440 445
Ser Tyr Lys Arg Ser Asn Phe Tyr Ile Lys Val Arg Pro Ala Glu Leu
450 455 460
Glu Gln Phe Glu Ser Thr Ile Gly Phe Lys Leu Pro Asn His Arg Ala
465 470 475 480
Ala Lys Arg Leu Trp Lys Val Cys Val Glu His His Thr Phe Tyr Arg
485 490 495
Leu Val Ser Pro Glu Gln Pro Pro Lys Ala Lys Phe Leu Thr Leu Gly
500 505 510
Ser Lys Phe Arg Tyr Ser Gly Arg Thr Gln Ala Gln Thr Arg Gln Ala
515 520 525
Ser Thr Leu Ile Asp Arg Pro Ala Pro His Phe Glu Arg Thr Ser Ser
530 535 540
Lys Arg Val Ser Arg Ser Leu Asp Gly Ala Pro Ile Gly Val Met Asp
545 550 555 560
Gln Ser Leu Met Lys Asp Phe Pro Gly Ala Ala Gly Glu Ile Ser Ala
565 570 575
Tyr Gly Pro Gly Leu Val Ser Ile Ala Val Val Gln Asp Gly Asp Gly
580 585 590
Arg Arg Glu Val Arg Ser Pro Thr Lys Ala Pro His Leu Gln Leu Ile
595 600 605
Glu Gly Lys Lys Asn Ser Leu Arg Val Glu Gly Asp Asn Ile Tyr Val
610 615 620
Arg His Ser Asn Leu Met Leu Glu Glu Leu Asp Lys Ala Gln Glu Asp
625 630 635 640
Ile Leu Lys His Gln Ala Ser Ile Ser Glu Leu Lys Arg Asn Phe Met
645 650 655
Glu Ser Thr Pro Glu Pro Arg Pro Asn Glu Trp Glu Lys Arg Arg Ile
660 665 670
Thr Pro Leu Ser Leu Gln Thr Gln Gly Ser Ser His Glu Thr Leu Asn
675 680 685
Ile Val Glu Glu Lys Lys Arg Ala Glu Val Gly Lys Asp Glu Arg Val
690 695 700
Ile Thr Glu Glu Met Asn Gly Lys Glu Ile Ser Pro Gly Ser Gly Pro
705 710 715 720
Gly Glu Ile Arg Lys Val Glu Pro Val Thr Gln Lys Asp Ser Thr Ser
725 730 735
Leu Ser Ser Glu Ser Ser Ser Ser Ser Ser Glu Ser Glu Glu Glu Asp
740 745 750
Val Gly Glu Tyr Arg Pro His His Arg Val Thr Glu Gly Thr Ile Arg
755 760 765
Glu Glu Gln Glu Tyr Glu Glu Glu Val Glu Glu Glu Pro Arg Pro Ala
770 775 780
Ala Lys Val Val Glu Arg Glu Glu Ala Val Pro Glu Ala Ser Pro Val
785 790 795 800
Thr Gln Ala Gly Ala Ser Val Ile Thr Val Glu Thr Val Ile Gln Glu
805 810 815
Asn Val Gly Ala Gln Lys Ile Pro Gly Glu Lys Ser Val His Glu Gly
820 825 830
Ala Leu Lys Gln Asp Met Gly Glu Glu Ala Glu Glu Glu Pro Gln Lys
835 840 845
Val Asn Gly Glu Val Ser His Val Asp Ile Asp Val Leu Pro Gln Ile
850 855 860
Ile Cys Cys Ser Glu Pro Pro Val Val Lys Thr Glu Met Val Thr Ile
865 870 875 880
Ser Asp Ala Ser Gln Arg Thr Glu Ile Ser Thr Lys Glu Val Pro Ile
885 890 895
Val Gln Thr Glu Thr Lys Thr Ile Thr Tyr Glu Ser Pro Gln Ile Asp
900 905 910
Gly Gly Ala Gly Gly Asp Ser Gly Thr Leu Leu Thr Ala Gln Thr Ile
915 920 925
Thr Ser Glu Ser Val Ser Thr Thr Thr Thr Thr His Ile Thr Lys Thr
930 935 940
Val Lys Gly Gly Ile Ser Glu Thr Arg Ile Glu Lys Arg Ile Val Ile
945 950 955 960
Thr Gly Asp Gly Asp Ile Asp His Asp Gln Ala Leu Ala Gln Ala Ile
965 970 975
Arg Glu Ala Arg Glu Gln His Pro Asp Met Ser Val Thr Arg Val Val
980 985 990
Val His Lys Glu Thr Glu Leu Ala Glu Glu Gly Glu Asp
995 1000 1005
<210> 56
<211> 219
<212> PRT
<213> 智人(Homo sapiens)
<400> 56
Met Leu Arg Ala Gly Ala Pro Thr Gly Asp Leu Pro Arg Ala Gly Glu
1 5 10 15
Val His Thr Gly Thr Thr Ile Met Ala Val Glu Phe Asp Gly Gly Val
20 25 30
Val Met Gly Ser Asp Ser Arg Val Ser Ala Gly Glu Ala Val Val Asn
35 40 45
Arg Val Phe Asp Lys Leu Ser Pro Leu His Glu Arg Ile Tyr Cys Ala
50 55 60
Leu Ser Gly Ser Ala Ala Asp Ala Gln Ala Val Ala Asp Met Ala Ala
65 70 75 80
Tyr Gln Leu Glu Leu His Gly Ile Glu Leu Glu Glu Pro Pro Leu Val
85 90 95
Leu Ala Ala Ala Asn Val Val Arg Asn Ile Ser Tyr Lys Tyr Arg Glu
100 105 110
Asp Leu Ser Ala His Leu Met Val Ala Gly Trp Asp Gln Arg Glu Gly
115 120 125
Gly Gln Val Tyr Gly Thr Leu Gly Gly Met Leu Thr Arg Gln Pro Phe
130 135 140
Ala Ile Gly Gly Ser Gly Ser Thr Phe Ile Tyr Gly Tyr Val Asp Ala
145 150 155 160
Ala Tyr Lys Pro Gly Met Ser Pro Glu Glu Cys Arg Arg Phe Thr Thr
165 170 175
Asp Ala Ile Ala Leu Ala Met Ser Arg Asp Gly Ser Ser Gly Gly Val
180 185 190
Ile Tyr Leu Val Thr Ile Thr Ala Ala Gly Val Asp His Arg Val Ile
195 200 205
Leu Gly Asn Glu Leu Pro Lys Phe Tyr Asp Glu
210 215
<210> 57
<211> 151
<212> PRT
<213> 智人(Homo sapiens)
<400> 57
Met Ala Pro Arg Lys Gly Lys Glu Lys Lys Glu Glu Gln Val Ile Ser
1 5 10 15
Leu Gly Pro Gln Val Ala Glu Gly Glu Asn Val Phe Gly Val Cys His
20 25 30
Ile Phe Ala Ser Phe Asn Asp Thr Phe Val His Val Thr Asp Leu Ser
35 40 45
Gly Lys Glu Thr Ile Cys Arg Val Thr Gly Gly Met Lys Val Lys Ala
50 55 60
Asp Arg Asp Glu Ser Ser Pro Tyr Ala Ala Met Leu Ala Ala Gln Asp
65 70 75 80
Val Ala Gln Arg Cys Lys Glu Leu Gly Ile Thr Ala Leu His Ile Lys
85 90 95
Leu Arg Ala Thr Gly Gly Asn Arg Thr Lys Thr Pro Gly Pro Gly Ala
100 105 110
Gln Ser Ala Leu Arg Ala Leu Ala Arg Ser Gly Met Lys Ile Gly Arg
115 120 125
Ile Glu Asp Val Thr Pro Ile Pro Ser Asp Ser Thr Arg Arg Lys Gly
130 135 140
Gly Arg Arg Gly Arg Arg Leu
145 150
<210> 58
<211> 266
<212> PRT
<213> 智人(Homo sapiens)
<400> 58
Met Pro Lys Gly Lys Lys Ala Lys Gly Lys Lys Val Ala Pro Ala Pro
1 5 10 15
Ala Val Val Lys Lys Gln Glu Ala Lys Lys Val Val Asn Pro Leu Phe
20 25 30
Glu Lys Arg Pro Lys Asn Phe Gly Ile Gly Gln Asp Ile Gln Pro Lys
35 40 45
Arg Asp Leu Thr Arg Phe Val Lys Trp Pro Arg Tyr Ile Arg Leu Gln
50 55 60
Arg Gln Arg Ala Ile Leu Tyr Lys Arg Leu Lys Val Pro Pro Ala Ile
65 70 75 80
Asn Gln Phe Thr Gln Ala Leu Asp Arg Gln Thr Ala Thr Gln Leu Leu
85 90 95
Lys Leu Ala His Lys Tyr Arg Pro Glu Thr Lys Gln Glu Lys Lys Gln
100 105 110
Arg Leu Leu Ala Arg Ala Glu Lys Lys Ala Ala Gly Lys Gly Asp Val
115 120 125
Pro Thr Lys Arg Pro Pro Val Leu Arg Ala Gly Val Asn Thr Val Thr
130 135 140
Thr Leu Val Glu Asn Lys Lys Ala Gln Leu Val Val Ile Ala His Asp
145 150 155 160
Val Asp Pro Ile Glu Leu Val Val Phe Leu Pro Ala Leu Cys Arg Lys
165 170 175
Met Gly Val Pro Tyr Cys Ile Ile Lys Gly Lys Ala Arg Leu Gly Arg
180 185 190
Leu Val His Arg Lys Thr Cys Thr Thr Val Ala Phe Thr Gln Val Asn
195 200 205
Ser Glu Asp Lys Gly Ala Leu Ala Lys Leu Val Glu Ala Ile Arg Thr
210 215 220
Asn Tyr Asn Asp Arg Tyr Asp Glu Ile Arg Arg His Trp Gly Gly Asn
225 230 235 240
Val Leu Gly Pro Lys Ser Val Ala Arg Ile Ala Lys Leu Glu Lys Ala
245 250 255
Lys Ala Lys Glu Leu Ala Thr Lys Leu Gly
260 265
<210> 59
<211> 742
<212> PRT
<213> 智人(Homo sapiens)
<400> 59
Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr
1 5 10 15
Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn
20 25 30
Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala
35 40 45
Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys
50 55 60
Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp
65 70 75 80
Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln
85 90 95
Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg
100 105 110
Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys
115 120 125
Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp
130 135 140
Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn
145 150 155 160
Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly
165 170 175
Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu
180 185 190
Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn
195 200 205
Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln
210 215 220
Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp
225 230 235 240
Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp
245 250 255
Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn
260 265 270
Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser
275 280 285
Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser
290 295 300
Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp
305 310 315 320
Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe
325 330 335
Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr
340 345 350
Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg
355 360 365
Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser
370 375 380
Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg
385 390 395 400
Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn
405 410 415
Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly
420 425 430
Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg
435 440 445
Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly
450 455 460
Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro
465 470 475 480
Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg
485 490 495
Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly
500 505 510
Ser Pro Gly Lys Pro Gly Pro Gln Gly Ser Ser Gly Asp Pro Gly Pro
515 520 525
Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro
530 535 540
Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly
545 550 555 560
Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro
565 570 575
Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu
580 585 590
Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro
595 600 605
Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu
610 615 620
Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser
625 630 635 640
His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys
645 650 655
Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu
660 665 670
Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys
675 680 685
Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro
690 695 700
Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe
705 710 715 720
Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr
725 730 735
Val Leu Ser Ser Ala Leu
740
<210> 60
<211> 1214
<212> PRT
<213> 智人(Homo sapiens)
<400> 60
Met Ala Val Arg Lys Lys Asp Gly Gly Pro Asn Val Lys Tyr Tyr Glu
1 5 10 15
Ala Ala Asp Thr Val Thr Gln Phe Asp Asn Val Arg Leu Trp Leu Gly
20 25 30
Lys Asn Tyr Lys Lys Tyr Ile Gln Ala Glu Pro Pro Thr Asn Lys Ser
35 40 45
Leu Ser Ser Leu Val Val Gln Leu Leu Gln Phe Gln Glu Glu Val Phe
50 55 60
Gly Lys His Val Ser Asn Ala Pro Leu Thr Lys Leu Pro Ile Lys Cys
65 70 75 80
Phe Leu Asp Phe Lys Ala Gly Gly Ser Leu Cys His Ile Leu Ala Ala
85 90 95
Ala Tyr Lys Phe Lys Ser Asp Gln Gly Trp Arg Arg Tyr Asp Phe Gln
100 105 110
Asn Pro Ser Arg Met Asp Arg Asn Val Glu Met Phe Met Thr Ile Glu
115 120 125
Lys Ser Leu Val Gln Asn Asn Cys Leu Ser Arg Pro Asn Ile Phe Leu
130 135 140
Cys Pro Glu Ile Glu Pro Lys Leu Leu Gly Lys Leu Lys Asp Ile Ile
145 150 155 160
Lys Arg His Gln Gly Thr Val Thr Glu Asp Lys Asn Asn Ala Ser His
165 170 175
Val Val Tyr Pro Val Pro Gly Asn Leu Glu Glu Glu Glu Trp Val Arg
180 185 190
Pro Val Met Lys Arg Asp Lys Gln Val Leu Leu His Trp Gly Tyr Tyr
195 200 205
Pro Asp Ser Tyr Asp Thr Trp Ile Pro Ala Ser Glu Ile Glu Ala Ser
210 215 220
Val Glu Asp Ala Pro Thr Pro Glu Lys Pro Arg Lys Val His Ala Lys
225 230 235 240
Trp Ile Leu Asp Thr Asp Thr Phe Asn Glu Trp Met Asn Glu Glu Asp
245 250 255
Tyr Glu Val Asn Asp Asp Lys Asn Pro Val Ser Arg Arg Lys Lys Ile
260 265 270
Ser Ala Lys Thr Leu Thr Asp Glu Val Asn Ser Pro Asp Ser Asp Arg
275 280 285
Arg Asp Lys Lys Gly Gly Asn Tyr Lys Lys Arg Lys Arg Ser Pro Ser
290 295 300
Pro Ser Pro Thr Pro Glu Ala Lys Lys Lys Asn Ala Lys Lys Gly Pro
305 310 315 320
Ser Thr Pro Tyr Thr Lys Ser Lys Arg Gly His Arg Glu Glu Glu Gln
325 330 335
Glu Asp Leu Thr Lys Asp Met Asp Glu Pro Ser Pro Val Pro Asn Val
340 345 350
Glu Glu Val Thr Leu Pro Lys Thr Val Asn Thr Lys Lys Asp Ser Glu
355 360 365
Ser Ala Pro Val Lys Gly Gly Thr Met Thr Asp Leu Asp Glu Gln Glu
370 375 380
Asp Glu Ser Met Glu Thr Thr Gly Lys Asp Glu Asp Glu Asn Ser Thr
385 390 395 400
Gly Asn Lys Gly Glu Gln Thr Lys Asn Pro Asp Leu His Glu Asp Asn
405 410 415
Val Thr Glu Gln Thr His His Ile Ile Ile Pro Ser Tyr Ala Ala Trp
420 425 430
Phe Asp Tyr Asn Ser Val His Ala Ile Glu Arg Arg Ala Leu Pro Glu
435 440 445
Phe Phe Asn Gly Lys Asn Lys Ser Lys Thr Pro Glu Ile Tyr Leu Ala
450 455 460
Tyr Arg Asn Phe Met Ile Asp Thr Tyr Arg Leu Asn Pro Gln Glu Tyr
465 470 475 480
Leu Thr Ser Thr Ala Cys Arg Arg Asn Leu Ala Gly Asp Val Cys Ala
485 490 495
Ile Met Arg Val His Ala Phe Leu Glu Gln Trp Gly Leu Ile Asn Tyr
500 505 510
Gln Val Asp Ala Glu Ser Arg Pro Thr Pro Met Gly Pro Pro Pro Thr
515 520 525
Ser His Phe His Val Leu Ala Asp Thr Pro Ser Gly Leu Val Pro Leu
530 535 540
Gln Pro Lys Thr Pro Gln Gln Thr Ser Ala Ser Gln Gln Met Leu Asn
545 550 555 560
Phe Pro Asp Lys Gly Lys Glu Lys Pro Thr Asp Met Gln Asn Phe Gly
565 570 575
Leu Arg Thr Asp Met Tyr Thr Lys Lys Asn Val Pro Ser Lys Ser Lys
580 585 590
Ala Ala Ala Ser Ala Thr Arg Glu Trp Thr Glu Gln Glu Thr Leu Leu
595 600 605
Leu Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp Trp Asn Lys Val Ser
610 615 620
Glu His Val Gly Ser Arg Thr Gln Asp Glu Cys Ile Leu His Phe Leu
625 630 635 640
Arg Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asp Ser Glu Ala Ser Leu
645 650 655
Gly Pro Leu Ala Tyr Gln Pro Ile Pro Phe Ser Gln Ser Gly Asn Pro
660 665 670
Val Met Ser Thr Val Ala Phe Leu Ala Ser Val Val Asp Pro Arg Val
675 680 685
Ala Ser Ala Ala Ala Lys Ser Ala Leu Glu Glu Phe Ser Lys Met Lys
690 695 700
Glu Glu Val Pro Thr Ala Leu Val Glu Ala His Val Arg Lys Val Glu
705 710 715 720
Glu Ala Ala Lys Val Thr Gly Lys Ala Asp Pro Ala Phe Gly Leu Glu
725 730 735
Ser Ser Gly Ile Ala Gly Thr Thr Ser Asp Glu Pro Glu Arg Ile Glu
740 745 750
Glu Ser Gly Asn Asp Glu Ala Arg Val Glu Gly Gln Ala Thr Asp Glu
755 760 765
Lys Lys Glu Pro Lys Glu Pro Arg Glu Gly Gly Gly Ala Ile Glu Glu
770 775 780
Glu Ala Lys Glu Lys Thr Ser Glu Ala Pro Lys Lys Asp Glu Glu Lys
785 790 795 800
Gly Lys Glu Gly Asp Ser Glu Lys Glu Ser Glu Lys Ser Asp Gly Asp
805 810 815
Pro Ile Val Asp Pro Glu Lys Glu Lys Glu Pro Lys Glu Gly Gln Glu
820 825 830
Glu Val Leu Lys Glu Val Val Glu Ser Glu Gly Glu Arg Lys Thr Lys
835 840 845
Val Glu Arg Asp Ile Gly Glu Gly Asn Leu Ser Thr Ala Ala Ala Ala
850 855 860
Ala Leu Ala Ala Ala Ala Val Lys Ala Lys His Leu Ala Ala Val Glu
865 870 875 880
Glu Arg Lys Ile Lys Ser Leu Val Ala Leu Leu Val Glu Thr Gln Met
885 890 895
Lys Lys Leu Glu Ile Lys Leu Arg His Phe Glu Glu Leu Glu Thr Ile
900 905 910
Met Asp Arg Glu Arg Glu Ala Leu Glu Tyr Gln Arg Gln Gln Leu Leu
915 920 925
Ala Asp Arg Gln Ala Phe His Met Glu Gln Leu Lys Tyr Ala Glu Met
930 935 940
Arg Ala Arg Gln Gln His Phe Gln Gln Met His Gln Gln Gln Gln Gln
945 950 955 960
Pro Pro Pro Ala Leu Pro Pro Gly Ser Gln Pro Ile Pro Pro Thr Gly
965 970 975
Ala Ala Gly Pro Pro Ala Val His Gly Leu Ala Val Ala Pro Ala Ser
980 985 990
Val Val Pro Ala Pro Ala Gly Ser Gly Ala Pro Pro Gly Ser Leu Gly
995 1000 1005
Pro Ser Glu Gln Ile Gly Gln Ala Gly Ser Thr Ala Gly Pro Gln
1010 1015 1020
Gln Gln Gln Pro Ala Gly Ala Pro Gln Pro Gly Ala Val Pro Pro
1025 1030 1035
Gly Val Pro Pro Pro Gly Pro His Gly Pro Ser Pro Phe Pro Asn
1040 1045 1050
Gln Gln Thr Pro Pro Ser Met Met Pro Gly Ala Val Pro Gly Ser
1055 1060 1065
Gly His Pro Gly Val Ala Gly Asn Ala Pro Leu Gly Leu Pro Phe
1070 1075 1080
Gly Met Pro Pro Pro Pro Pro Pro Pro Ala Pro Ser Ile Ile Pro
1085 1090 1095
Phe Gly Ser Leu Ala Asp Ser Ile Ser Ile Asn Leu Pro Ala Pro
1100 1105 1110
Pro Asn Leu His Gly His His His His Leu Pro Phe Ala Pro Gly
1115 1120 1125
Thr Leu Pro Pro Pro Asn Leu Pro Val Ser Met Ala Asn Pro Leu
1130 1135 1140
His Pro Asn Leu Pro Ala Thr Thr Thr Met Pro Ser Ser Leu Pro
1145 1150 1155
Leu Gly Pro Gly Leu Gly Ser Ala Ala Ala Gln Ser Pro Ala Ile
1160 1165 1170
Val Ala Ala Val Gln Gly Asn Leu Leu Pro Ser Ala Ser Pro Leu
1175 1180 1185
Pro Asp Pro Gly Thr Pro Leu Pro Pro Asp Pro Thr Ala Pro Ser
1190 1195 1200
Pro Gly Thr Val Thr Pro Val Pro Pro Pro Gln
1205 1210
<210> 61
<211> 199
<212> PRT
<213> 智人(Homo sapiens)
<400> 61
Met Ala Asn Arg Gly Pro Ala Tyr Gly Leu Ser Arg Glu Val Gln Gln
1 5 10 15
Lys Ile Glu Lys Gln Tyr Asp Ala Asp Leu Glu Gln Ile Leu Ile Gln
20 25 30
Trp Ile Thr Thr Gln Cys Arg Lys Asp Val Gly Arg Pro Gln Pro Gly
35 40 45
Arg Glu Asn Phe Gln Asn Trp Leu Lys Asp Gly Thr Val Leu Cys Glu
50 55 60
Leu Ile Asn Ala Leu Tyr Pro Glu Gly Gln Ala Pro Val Lys Lys Ile
65 70 75 80
Gln Ala Ser Thr Met Ala Phe Lys Gln Met Glu Gln Ile Ser Gln Phe
85 90 95
Leu Gln Ala Ala Glu Arg Tyr Gly Ile Asn Thr Thr Asp Ile Phe Gln
100 105 110
Thr Val Asp Leu Trp Glu Gly Lys Asn Met Ala Cys Val Gln Arg Thr
115 120 125
Leu Met Asn Leu Gly Gly Leu Ala Val Ala Arg Asp Asp Gly Leu Phe
130 135 140
Ser Gly Asp Pro Asn Trp Phe Pro Lys Lys Ser Lys Glu Asn Pro Arg
145 150 155 160
Asn Phe Ser Asp Asn Gln Leu Gln Glu Gly Lys Asn Val Ile Gly Leu
165 170 175
Gln Met Gly Thr Asn Arg Gly Ala Ser Gln Ala Gly Met Thr Gly Tyr
180 185 190
Gly Met Pro Arg Gln Ile Leu
195
<210> 62
<211> 539
<212> PRT
<213> 智人(Homo sapiens)
<400> 62
Met Pro Glu Asn Val Ala Pro Arg Ser Gly Ala Thr Ala Gly Ala Ala
1 5 10 15
Gly Gly Arg Gly Lys Gly Ala Tyr Gln Asp Arg Asp Lys Pro Ala Gln
20 25 30
Ile Arg Phe Ser Asn Ile Ser Ala Ala Lys Ala Val Ala Asp Ala Ile
35 40 45
Arg Thr Ser Leu Gly Pro Lys Gly Met Asp Lys Met Ile Gln Asp Gly
50 55 60
Lys Gly Asp Val Thr Ile Thr Asn Asp Gly Ala Thr Ile Leu Lys Gln
65 70 75 80
Met Gln Val Leu His Pro Ala Ala Arg Met Leu Val Glu Leu Ser Lys
85 90 95
Ala Gln Asp Ile Glu Ala Gly Asp Gly Thr Thr Ser Val Val Ile Ile
100 105 110
Ala Gly Ser Leu Leu Asp Ser Cys Thr Lys Leu Leu Gln Lys Gly Ile
115 120 125
His Pro Thr Ile Ile Ser Glu Ser Phe Gln Lys Ala Leu Glu Lys Gly
130 135 140
Ile Glu Ile Leu Thr Asp Met Ser Arg Pro Val Glu Leu Ser Asp Arg
145 150 155 160
Glu Thr Leu Leu Asn Ser Ala Thr Thr Ser Leu Asn Ser Lys Val Val
165 170 175
Ser Gln Tyr Ser Ser Leu Leu Ser Pro Met Ser Val Asn Ala Val Met
180 185 190
Lys Val Ile Asp Pro Ala Thr Ala Thr Ser Val Asp Leu Arg Asp Ile
195 200 205
Lys Ile Val Lys Lys Leu Gly Gly Thr Ile Asp Asp Cys Glu Leu Val
210 215 220
Glu Gly Leu Val Leu Thr Gln Lys Val Ser Asn Ser Gly Ile Thr Arg
225 230 235 240
Val Glu Lys Ala Lys Ile Gly Leu Ile Gln Phe Cys Leu Ser Ala Pro
245 250 255
Lys Thr Asp Met Asp Asn Gln Ile Val Val Ser Asp Tyr Ala Gln Met
260 265 270
Asp Arg Val Leu Arg Glu Glu Arg Ala Tyr Ile Leu Asn Leu Val Lys
275 280 285
Gln Ile Lys Lys Thr Gly Cys Asn Val Leu Leu Ile Gln Lys Ser Ile
290 295 300
Leu Arg Asp Ala Leu Ser Asp Leu Ala Leu His Phe Leu Asn Lys Met
305 310 315 320
Lys Ile Met Val Ile Lys Asp Ile Glu Arg Glu Asp Ile Glu Phe Ile
325 330 335
Cys Lys Thr Ile Gly Thr Lys Pro Val Ala His Ile Asp Gln Phe Thr
340 345 350
Ala Asp Met Leu Gly Ser Ala Glu Leu Ala Glu Glu Val Asn Leu Asn
355 360 365
Gly Ser Gly Lys Leu Leu Lys Ile Thr Gly Cys Ala Ser Pro Gly Lys
370 375 380
Thr Val Thr Ile Val Val Arg Gly Ser Asn Lys Leu Val Ile Glu Glu
385 390 395 400
Ala Glu Arg Ser Ile His Asp Ala Leu Cys Val Ile Arg Cys Leu Val
405 410 415
Lys Lys Arg Ala Leu Ile Ala Gly Gly Gly Ala Pro Glu Ile Glu Leu
420 425 430
Ala Leu Arg Leu Thr Glu Tyr Ser Arg Thr Leu Ser Gly Met Glu Ser
435 440 445
Tyr Cys Val Arg Ala Phe Ala Asp Ala Met Glu Val Ile Pro Ser Thr
450 455 460
Leu Ala Glu Asn Ala Gly Leu Asn Pro Ile Ser Thr Val Thr Glu Leu
465 470 475 480
Arg Asn Arg His Ala Gln Gly Glu Lys Thr Ala Gly Ile Asn Val Arg
485 490 495
Lys Gly Gly Ile Ser Asn Ile Leu Glu Glu Leu Val Val Gln Pro Leu
500 505 510
Leu Val Ser Val Ser Ala Leu Thr Leu Ala Thr Glu Thr Val Arg Ser
515 520 525
Ile Leu Lys Ile Asp Asp Val Val Asn Thr Arg
530 535
<210> 63
<211> 758
<212> PRT
<213> 智人(Homo sapiens)
<400> 63
Met Ala Gln Arg Lys Asn Ala Lys Ser Ser Gly Asn Ser Ser Ser Ser
1 5 10 15
Gly Ser Gly Ser Gly Ser Thr Ser Ala Gly Ser Ser Ser Pro Gly Ala
20 25 30
Arg Arg Glu Thr Lys His Gly Gly His Lys Asn Gly Arg Lys Gly Gly
35 40 45
Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile Ala Leu Leu
50 55 60
Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu Val Asp Tyr
65 70 75 80
Glu Glu Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly Asp Gly
85 90 95
Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Lys Glu Arg
100 105 110
Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu Pro His Thr
115 120 125
Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln Asn Ile Glu
130 135 140
Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met Val His
145 150 155 160
Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp Gly Pro Thr
165 170 175
Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala Thr Asp Val
180 185 190
Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His Glu Glu Thr
195 200 205
Glu His Ser Tyr His Val Glu Glu Thr Val Ser Gln Asp Cys Asn Gln
210 215 220
Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn Pro Asp Ser Ser Glu
225 230 235 240
Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp Asp Val Thr
245 250 255
Tyr Gln Val Tyr Glu Glu Gln Ala Val Tyr Glu Pro Leu Glu Asn Glu
260 265 270
Gly Ile Glu Ile Thr Glu Val Thr Ala Pro Pro Glu Asp Asn Pro Val
275 280 285
Glu Asp Ser Gln Val Ile Val Glu Glu Val Ser Ile Phe Pro Val Glu
290 295 300
Glu Gln Gln Glu Val Pro Pro Glu Thr Asn Arg Lys Thr Asp Asp Pro
305 310 315 320
Glu Gln Lys Ala Lys Val Lys Lys Lys Lys Pro Lys Leu Leu Asn Lys
325 330 335
Phe Asp Lys Thr Ile Lys Ala Glu Leu Asp Ala Ala Glu Lys Leu Arg
340 345 350
Lys Arg Gly Lys Ile Glu Glu Ala Val Asn Ala Phe Lys Glu Leu Val
355 360 365
Arg Lys Tyr Pro Gln Ser Pro Arg Ala Arg Tyr Gly Lys Ala Gln Cys
370 375 380
Glu Asp Asp Leu Ala Glu Lys Arg Arg Ser Asn Glu Val Leu Arg Gly
385 390 395 400
Ala Ile Glu Thr Tyr Gln Glu Val Ala Ser Leu Pro Asp Val Pro Ala
405 410 415
Asp Leu Leu Lys Leu Ser Leu Lys Arg Arg Ser Asp Arg Gln Gln Phe
420 425 430
Leu Gly His Met Arg Gly Ser Leu Leu Thr Leu Gln Arg Leu Val Gln
435 440 445
Leu Phe Pro Asn Asp Thr Ser Leu Lys Asn Asp Leu Gly Val Gly Tyr
450 455 460
Leu Leu Ile Gly Asp Asn Asp Asn Ala Lys Lys Val Tyr Glu Glu Val
465 470 475 480
Leu Ser Val Thr Pro Asn Asp Gly Phe Ala Lys Val His Tyr Gly Phe
485 490 495
Ile Leu Lys Ala Gln Asn Lys Ile Ala Glu Ser Ile Pro Tyr Leu Lys
500 505 510
Glu Gly Ile Glu Ser Gly Asp Pro Gly Thr Asp Asp Gly Arg Phe Tyr
515 520 525
Phe His Leu Gly Asp Ala Met Gln Arg Val Gly Asn Lys Glu Ala Tyr
530 535 540
Lys Trp Tyr Glu Leu Gly His Lys Arg Gly His Phe Ala Ser Val Trp
545 550 555 560
Gln Arg Ser Leu Tyr Asn Val Asn Gly Leu Lys Ala Gln Pro Trp Trp
565 570 575
Thr Pro Lys Glu Thr Gly Tyr Thr Glu Leu Val Lys Ser Leu Glu Arg
580 585 590
Asn Trp Lys Leu Ile Arg Asp Glu Gly Leu Ala Val Met Asp Lys Ala
595 600 605
Lys Gly Leu Phe Leu Pro Glu Asp Glu Asn Leu Arg Glu Lys Gly Asp
610 615 620
Trp Ser Gln Phe Thr Leu Trp Gln Gln Gly Arg Arg Asn Glu Asn Ala
625 630 635 640
Cys Lys Gly Ala Pro Lys Thr Cys Thr Leu Leu Glu Lys Phe Pro Glu
645 650 655
Thr Thr Gly Cys Arg Arg Gly Gln Ile Lys Tyr Ser Ile Met His Pro
660 665 670
Gly Thr His Val Trp Pro His Thr Gly Pro Thr Asn Cys Arg Leu Arg
675 680 685
Met His Leu Gly Leu Val Ile Pro Lys Glu Gly Cys Lys Ile Arg Cys
690 695 700
Ala Asn Glu Thr Lys Thr Trp Glu Glu Gly Lys Val Leu Ile Phe Asp
705 710 715 720
Asp Ser Phe Glu His Glu Val Trp Gln Asp Ala Ser Ser Phe Arg Leu
725 730 735
Ile Phe Ile Val Asp Val Trp His Pro Glu Leu Thr Pro Gln Gln Arg
740 745 750
Arg Ser Leu Pro Ala Ile
755
<210> 64
<211> 491
<212> PRT
<213> 智人(Homo sapiens)
<400> 64
Met Pro Leu Pro Val Gln Val Phe Asn Leu Gln Gly Ala Val Glu Pro
1 5 10 15
Met Gln Ile Asp Val Asp Pro Gln Glu Asp Pro Gln Asn Ala Pro Asp
20 25 30
Val Asn Tyr Val Val Glu Asn Pro Ser Leu Asp Leu Glu Gln Tyr Ala
35 40 45
Ala Ser Tyr Ser Gly Leu Met Arg Ile Glu Arg Leu Gln Phe Ile Ala
50 55 60
Asp His Cys Pro Thr Leu Arg Val Glu Ala Leu Lys Met Ala Leu Ser
65 70 75 80
Phe Val Gln Arg Thr Phe Asn Val Asp Met Tyr Glu Glu Ile His Arg
85 90 95
Lys Leu Ser Glu Ala Thr Arg Ser Ser Leu Arg Glu Leu Gln Asn Ala
100 105 110
Pro Asp Ala Ile Pro Glu Ser Gly Val Glu Pro Pro Ala Leu Asp Thr
115 120 125
Ala Trp Val Glu Ala Thr Arg Lys Lys Ala Leu Leu Lys Leu Glu Lys
130 135 140
Leu Asp Thr Asp Leu Lys Asn Tyr Lys Gly Asn Ser Ile Lys Glu Ser
145 150 155 160
Ile Arg Arg Gly His Asp Asp Leu Gly Asp His Tyr Leu Asp Cys Gly
165 170 175
Asp Leu Ser Asn Ala Leu Lys Cys Tyr Ser Arg Ala Arg Asp Tyr Cys
180 185 190
Thr Ser Ala Lys His Val Ile Asn Met Cys Leu Asn Val Ile Lys Val
195 200 205
Ser Val Tyr Leu Gln Asn Trp Ser His Val Leu Ser Tyr Val Ser Lys
210 215 220
Ala Glu Ser Thr Pro Glu Ile Ala Glu Gln Arg Gly Glu Arg Asp Ser
225 230 235 240
Gln Thr Gln Ala Ile Leu Thr Lys Leu Lys Cys Ala Ala Gly Leu Ala
245 250 255
Glu Leu Ala Ala Arg Lys Tyr Lys Gln Ala Ala Lys Cys Leu Leu Leu
260 265 270
Ala Ser Phe Asp His Cys Asp Phe Pro Glu Leu Leu Ser Pro Ser Asn
275 280 285
Val Ala Ile Tyr Gly Gly Leu Cys Ala Leu Ala Thr Phe Asp Arg Gln
290 295 300
Glu Leu Gln Arg Asn Val Ile Ser Ser Ser Ser Phe Lys Leu Phe Leu
305 310 315 320
Glu Leu Glu Pro Gln Val Arg Asp Ile Ile Phe Lys Phe Tyr Glu Ser
325 330 335
Lys Tyr Ala Ser Cys Leu Lys Met Leu Asp Glu Met Lys Asp Asn Leu
340 345 350
Leu Leu Asp Met Tyr Leu Ala Pro His Val Arg Thr Leu Tyr Thr Gln
355 360 365
Ile Arg Asn Arg Ala Leu Ile Gln Tyr Phe Ser Pro Tyr Val Ser Ala
370 375 380
Asp Met His Arg Met Ala Ala Ala Phe Asn Thr Thr Val Ala Ala Leu
385 390 395 400
Glu Asp Glu Leu Thr Gln Leu Ile Leu Glu Gly Leu Ile Ser Ala Arg
405 410 415
Val Asp Ser His Ser Lys Ile Leu Tyr Ala Arg Asp Val Asp Gln Arg
420 425 430
Ser Thr Thr Phe Glu Lys Ser Leu Leu Met Gly Lys Glu Phe Gln Arg
435 440 445
Arg Ala Lys Ala Met Met Leu Arg Ala Ala Val Leu Arg Asn Gln Ile
450 455 460
His Val Lys Ser Pro Pro Arg Glu Gly Ser Gln Gly Glu Leu Thr Pro
465 470 475 480
Ala Asn Ser Gln Ser Arg Met Ser Thr Asn Met
485 490
<210> 65
<211> 1512
<212> PRT
<213> 智人(Homo sapiens)
<400> 65
Met Pro Ser Ser Ser Asp Thr Ala Leu Gly Gly Gly Gly Gly Leu Ser
1 5 10 15
Trp Ala Glu Lys Lys Leu Glu Glu Arg Arg Lys Arg Arg Arg Phe Leu
20 25 30
Ser Pro Gln Gln Pro Pro Leu Leu Leu Pro Leu Leu Gln Pro Gln Leu
35 40 45
Leu Gln Pro Pro Pro Pro Pro Pro Pro Leu Leu Phe Leu Ala Ala Pro
50 55 60
Gly Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser Ser Cys
65 70 75 80
Phe Ser Pro Gly Pro Pro Leu Glu Val Lys Arg Leu Ala Arg Gly Lys
85 90 95
Arg Arg Ala Gly Gly Arg Gln Lys Arg Arg Arg Gly Pro Arg Ala Gly
100 105 110
Gln Glu Ala Glu Lys Arg Arg Val Phe Ser Leu Pro Gln Pro Gln Gln
115 120 125
Asp Gly Gly Gly Gly Ala Ser Ser Gly Gly Gly Val Thr Pro Leu Val
130 135 140
Glu Tyr Glu Asp Val Ser Ser Gln Ser Glu Gln Gly Leu Leu Leu Gly
145 150 155 160
Gly Ala Ser Ala Ala Thr Ala Ala Thr Ala Ala Gly Gly Thr Gly Gly
165 170 175
Ser Gly Gly Ser Pro Ala Ser Ser Ser Gly Thr Gln Arg Arg Gly Glu
180 185 190
Gly Ser Glu Arg Arg Pro Arg Arg Asp Arg Arg Ser Ser Ser Gly Arg
195 200 205
Ser Lys Glu Arg His Arg Glu His Arg Arg Arg Asp Gly Gln Arg Gly
210 215 220
Gly Ser Glu Ala Ser Lys Ser Arg Ser Arg His Ser His Ser Gly Glu
225 230 235 240
Glu Arg Ala Glu Val Ala Lys Ser Gly Ser Ser Ser Ser Ser Gly Gly
245 250 255
Arg Arg Lys Ser Ala Ser Ala Thr Ser Ser Ser Ser Ser Ser Arg Lys
260 265 270
Asp Arg Asp Ser Lys Ala His Arg Ser Arg Thr Lys Ser Ser Lys Glu
275 280 285
Pro Pro Ser Ala Tyr Lys Glu Pro Pro Lys Ala Tyr Arg Glu Asp Lys
290 295 300
Thr Glu Pro Lys Ala Tyr Arg Arg Arg Arg Ser Leu Ser Pro Leu Gly
305 310 315 320
Gly Arg Asp Asp Ser Pro Val Ser His Arg Ala Ser Gln Ser Leu Arg
325 330 335
Ser Arg Lys Ser Pro Ser Pro Ala Gly Gly Gly Ser Ser Pro Tyr Ser
340 345 350
Arg Arg Leu Pro Arg Ser Pro Ser Pro Tyr Ser Arg Arg Arg Ser Pro
355 360 365
Ser Tyr Ser Arg His Ser Ser Tyr Glu Arg Gly Gly Asp Val Ser Pro
370 375 380
Ser Pro Tyr Ser Ser Ser Ser Trp Arg Arg Ser Arg Ser Pro Tyr Ser
385 390 395 400
Pro Val Leu Arg Arg Ser Gly Lys Ser Arg Ser Arg Ser Pro Tyr Ser
405 410 415
Ser Arg His Ser Arg Ser Arg Ser Arg His Arg Leu Ser Arg Ser Arg
420 425 430
Ser Arg His Ser Ser Ile Ser Pro Ser Thr Leu Thr Leu Lys Ser Ser
435 440 445
Leu Ala Ala Glu Leu Asn Lys Asn Lys Lys Ala Arg Ala Ala Glu Ala
450 455 460
Ala Arg Ala Ala Glu Ala Ala Lys Ala Ala Glu Ala Thr Lys Ala Ala
465 470 475 480
Glu Ala Ala Ala Lys Ala Ala Lys Ala Ser Asn Thr Ser Thr Pro Thr
485 490 495
Lys Gly Asn Thr Glu Thr Ser Ala Ser Ala Ser Gln Thr Asn His Val
500 505 510
Lys Asp Val Lys Lys Ile Lys Ile Glu His Ala Pro Ser Pro Ser Ser
515 520 525
Gly Gly Thr Leu Lys Asn Asp Lys Ala Lys Thr Lys Pro Pro Leu Gln
530 535 540
Val Thr Lys Val Glu Asn Asn Leu Ile Val Asp Lys Ala Thr Lys Lys
545 550 555 560
Ala Val Ile Val Gly Lys Glu Ser Lys Ser Ala Ala Thr Lys Glu Glu
565 570 575
Ser Val Ser Leu Lys Glu Lys Thr Lys Pro Leu Thr Pro Ser Ile Gly
580 585 590
Ala Lys Glu Lys Glu Gln His Val Ala Leu Val Thr Ser Thr Leu Pro
595 600 605
Pro Leu Pro Leu Pro Pro Met Leu Pro Glu Asp Lys Glu Ala Asp Ser
610 615 620
Leu Arg Gly Asn Ile Ser Val Lys Ala Val Lys Lys Glu Val Glu Lys
625 630 635 640
Lys Leu Arg Cys Leu Leu Ala Asp Leu Pro Leu Pro Pro Glu Leu Pro
645 650 655
Gly Gly Asp Asp Leu Ser Lys Ser Pro Glu Glu Lys Lys Thr Ala Thr
660 665 670
Gln Leu His Ser Lys Arg Arg Pro Lys Ile Cys Gly Pro Arg Tyr Gly
675 680 685
Glu Thr Lys Glu Lys Asp Ile Asp Trp Gly Lys Arg Cys Val Asp Lys
690 695 700
Phe Asp Ile Ile Gly Ile Ile Gly Glu Gly Thr Tyr Gly Gln Val Tyr
705 710 715 720
Lys Ala Arg Asp Lys Asp Thr Gly Glu Met Val Ala Leu Lys Lys Val
725 730 735
Arg Leu Asp Asn Glu Lys Glu Gly Phe Pro Ile Thr Ala Ile Arg Glu
740 745 750
Ile Lys Ile Leu Arg Gln Leu Thr His Gln Ser Ile Ile Asn Met Lys
755 760 765
Glu Ile Val Thr Asp Lys Glu Asp Ala Leu Asp Phe Lys Lys Asp Lys
770 775 780
Gly Ala Phe Tyr Leu Val Phe Glu Tyr Met Asp His Asp Leu Met Gly
785 790 795 800
Leu Leu Glu Ser Gly Leu Val His Phe Asn Glu Asn His Ile Lys Ser
805 810 815
Phe Met Arg Gln Leu Met Glu Gly Leu Asp Tyr Cys His Lys Lys Asn
820 825 830
Phe Leu His Arg Asp Ile Lys Cys Ser Asn Ile Leu Leu Asn Asn Arg
835 840 845
Gly Gln Ile Lys Leu Ala Asp Phe Gly Leu Ala Arg Leu Tyr Ser Ser
850 855 860
Glu Glu Ser Arg Pro Tyr Thr Asn Lys Val Ile Thr Leu Trp Tyr Arg
865 870 875 880
Pro Pro Glu Leu Leu Leu Gly Glu Glu Arg Tyr Thr Pro Ala Ile Asp
885 890 895
Val Trp Ser Cys Gly Cys Ile Leu Gly Glu Leu Phe Thr Lys Lys Pro
900 905 910
Ile Phe Gln Ala Asn Gln Glu Leu Ala Gln Leu Glu Leu Ile Ser Arg
915 920 925
Ile Cys Gly Ser Pro Cys Pro Ala Val Trp Pro Asp Val Ile Lys Leu
930 935 940
Pro Tyr Phe Asn Thr Met Lys Pro Lys Lys Gln Tyr Arg Arg Lys Leu
945 950 955 960
Arg Glu Glu Phe Val Phe Ile Pro Ala Ala Ala Leu Asp Leu Phe Asp
965 970 975
Tyr Met Leu Ala Leu Asp Pro Ser Lys Arg Cys Thr Ala Glu Gln Ala
980 985 990
Leu Gln Cys Glu Phe Leu Arg Asp Val Glu Pro Ser Lys Met Pro Pro
995 1000 1005
Pro Asp Leu Pro Leu Trp Gln Asp Cys His Glu Leu Trp Ser Lys
1010 1015 1020
Lys Arg Arg Arg Gln Lys Gln Met Gly Met Thr Asp Asp Val Ser
1025 1030 1035
Thr Ile Lys Ala Pro Arg Lys Asp Leu Ser Leu Gly Leu Asp Asp
1040 1045 1050
Ser Arg Thr Asn Thr Pro Gln Gly Val Leu Pro Ser Ser Gln Leu
1055 1060 1065
Lys Ser Gln Gly Ser Ser Asn Val Ala Pro Val Lys Thr Gly Pro
1070 1075 1080
Gly Gln His Leu Asn His Ser Glu Leu Ala Ile Leu Leu Asn Leu
1085 1090 1095
Leu Gln Ser Lys Thr Ser Val Asn Met Ala Asp Phe Val Gln Val
1100 1105 1110
Leu Asn Ile Lys Val Asn Ser Glu Thr Gln Gln Gln Leu Asn Lys
1115 1120 1125
Ile Asn Leu Pro Ala Gly Ile Leu Ala Thr Gly Glu Lys Gln Thr
1130 1135 1140
Asp Pro Ser Thr Pro Gln Gln Glu Ser Ser Lys Pro Leu Gly Gly
1145 1150 1155
Ile Gln Pro Ser Ser Gln Thr Ile Gln Pro Lys Val Glu Thr Asp
1160 1165 1170
Ala Ala Gln Ala Ala Val Gln Ser Ala Phe Ala Val Leu Leu Thr
1175 1180 1185
Gln Leu Ile Lys Ala Gln Gln Ser Lys Gln Lys Asp Val Leu Leu
1190 1195 1200
Glu Glu Arg Glu Asn Gly Ser Gly His Glu Ala Ser Leu Gln Leu
1205 1210 1215
Arg Pro Pro Pro Glu Pro Ser Thr Pro Val Ser Gly Gln Asp Asp
1220 1225 1230
Leu Ile Gln His Gln Asp Met Arg Ile Leu Glu Leu Thr Pro Glu
1235 1240 1245
Pro Asp Arg Pro Arg Ile Leu Pro Pro Asp Gln Arg Pro Pro Glu
1250 1255 1260
Pro Pro Glu Pro Pro Pro Val Thr Glu Glu Asp Leu Asp Tyr Arg
1265 1270 1275
Thr Glu Asn Gln His Val Pro Thr Thr Ser Ser Ser Leu Thr Asp
1280 1285 1290
Pro His Ala Gly Val Lys Ala Ala Leu Leu Gln Leu Leu Ala Gln
1295 1300 1305
His Gln Pro Gln Asp Asp Pro Lys Arg Glu Gly Gly Ile Asp Tyr
1310 1315 1320
Gln Ala Gly Asp Thr Tyr Val Ser Thr Ser Asp Tyr Lys Asp Asn
1325 1330 1335
Phe Gly Ser Ser Ser Phe Ser Ser Ala Pro Tyr Val Ser Asn Asp
1340 1345 1350
Gly Leu Gly Ser Ser Ser Ala Pro Pro Leu Glu Arg Arg Ser Phe
1355 1360 1365
Ile Gly Asn Ser Asp Ile Gln Ser Leu Asp Asn Tyr Ser Thr Ala
1370 1375 1380
Ser Ser His Ser Gly Gly Pro Pro Gln Pro Ser Ala Phe Ser Glu
1385 1390 1395
Ser Phe Pro Ser Ser Val Ala Gly Tyr Gly Asp Ile Tyr Leu Asn
1400 1405 1410
Ala Gly Pro Met Leu Phe Ser Gly Asp Lys Asp His Arg Phe Glu
1415 1420 1425
Tyr Ser His Gly Pro Ile Ala Val Leu Ala Asn Ser Ser Asp Pro
1430 1435 1440
Ser Thr Gly Pro Glu Ser Thr His Pro Leu Pro Ala Lys Met His
1445 1450 1455
Asn Tyr Asn Tyr Gly Gly Asn Leu Gln Glu Asn Pro Ser Gly Pro
1460 1465 1470
Ser Leu Met His Gly Gln Thr Trp Thr Ser Pro Ala Gln Gly Pro
1475 1480 1485
Gly Tyr Ser Gln Gly Tyr Arg Gly His Ile Ser Thr Ser Thr Gly
1490 1495 1500
Arg Gly Arg Gly Arg Gly Leu Pro Tyr
1505 1510
<210> 66
<211> 352
<212> PRT
<213> 智人(Homo sapiens)
<400> 66
Met Ser Val Ala Gly Leu Lys Lys Gln Phe His Lys Ala Thr Gln Lys
1 5 10 15
Val Ser Glu Lys Val Gly Gly Ala Glu Gly Thr Lys Leu Asp Asp Asp
20 25 30
Phe Lys Glu Met Glu Arg Lys Val Asp Val Thr Ser Arg Ala Val Met
35 40 45
Glu Ile Met Thr Lys Thr Ile Glu Tyr Leu Gln Pro Asn Pro Ala Ser
50 55 60
Arg Ala Lys Leu Ser Met Ile Asn Thr Met Ser Lys Ile Arg Gly Gln
65 70 75 80
Glu Lys Gly Pro Gly Tyr Pro Gln Ala Glu Ala Leu Leu Ala Glu Ala
85 90 95
Met Leu Lys Phe Gly Arg Glu Leu Gly Asp Asp Cys Asn Phe Gly Pro
100 105 110
Ala Leu Gly Glu Val Gly Glu Ala Met Arg Glu Leu Ser Glu Val Lys
115 120 125
Asp Ser Leu Asp Ile Glu Val Lys Gln Asn Phe Ile Asp Pro Leu Gln
130 135 140
Asn Leu His Asp Lys Asp Leu Arg Glu Ile Gln His His Leu Lys Lys
145 150 155 160
Leu Glu Gly Arg Arg Leu Asp Phe Asp Tyr Lys Lys Lys Arg Gln Gly
165 170 175
Lys Ile Pro Asp Glu Glu Leu Arg Gln Ala Leu Glu Lys Phe Asp Glu
180 185 190
Ser Lys Glu Ile Ala Glu Ser Ser Met Phe Asn Leu Leu Glu Met Asp
195 200 205
Ile Glu Gln Val Ser Gln Leu Ser Ala Leu Val Gln Ala Gln Leu Glu
210 215 220
Tyr His Lys Gln Ala Val Gln Ile Leu Gln Gln Val Thr Val Arg Leu
225 230 235 240
Glu Glu Arg Ile Arg Gln Ala Ser Ser Gln Pro Arg Arg Glu Tyr Gln
245 250 255
Pro Lys Pro Arg Met Ser Leu Glu Phe Pro Thr Gly Asp Ser Thr Gln
260 265 270
Pro Asn Gly Gly Leu Ser His Thr Gly Thr Pro Lys Pro Ser Gly Val
275 280 285
Gln Met Asp Gln Pro Cys Cys Arg Ala Leu Tyr Asp Phe Glu Pro Glu
290 295 300
Asn Glu Gly Glu Leu Gly Phe Lys Glu Gly Asp Ile Ile Thr Leu Thr
305 310 315 320
Asn Gln Ile Asp Glu Asn Trp Tyr Glu Gly Met Leu His Gly His Ser
325 330 335
Gly Phe Phe Pro Ile Asn Tyr Val Glu Ile Leu Val Ala Leu Pro His
340 345 350
<210> 67
<211> 142
<212> PRT
<213> 智人(Homo sapiens)
<400> 67
Met Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly
1 5 10 15
Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg
20 25 30
Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp
35 40 45
Leu Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala
50 55 60
Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn Ala
65 70 75 80
Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro
85 90 95
Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala
100 105 110
His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys
115 120 125
Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg
130 135 140
<210> 68
<211> 318
<212> PRT
<213> 智人(Homo sapiens)
<400> 68
Met Pro Lys Arg Gly Lys Lys Gly Ala Val Ala Glu Asp Gly Asp Glu
1 5 10 15
Leu Arg Thr Glu Pro Glu Ala Lys Lys Ser Lys Thr Ala Ala Lys Lys
20 25 30
Asn Asp Lys Glu Ala Ala Gly Glu Gly Pro Ala Leu Tyr Glu Asp Pro
35 40 45
Pro Asp Gln Lys Thr Ser Pro Ser Gly Lys Pro Ala Thr Leu Lys Ile
50 55 60
Cys Ser Trp Asn Val Asp Gly Leu Arg Ala Trp Ile Lys Lys Lys Gly
65 70 75 80
Leu Asp Trp Val Lys Glu Glu Ala Pro Asp Ile Leu Cys Leu Gln Glu
85 90 95
Thr Lys Cys Ser Glu Asn Lys Leu Pro Ala Glu Leu Gln Glu Leu Pro
100 105 110
Gly Leu Ser His Gln Tyr Trp Ser Ala Pro Ser Asp Lys Glu Gly Tyr
115 120 125
Ser Gly Val Gly Leu Leu Ser Arg Gln Cys Pro Leu Lys Val Ser Tyr
130 135 140
Gly Ile Gly Asp Glu Glu His Asp Gln Glu Gly Arg Val Ile Val Ala
145 150 155 160
Glu Phe Asp Ser Phe Val Leu Val Thr Ala Tyr Val Pro Asn Ala Gly
165 170 175
Arg Gly Leu Val Arg Leu Glu Tyr Arg Gln Arg Trp Asp Glu Ala Phe
180 185 190
Arg Lys Phe Leu Lys Gly Leu Ala Ser Arg Lys Pro Leu Val Leu Cys
195 200 205
Gly Asp Leu Asn Val Ala His Glu Glu Ile Asp Leu Arg Asn Pro Lys
210 215 220
Gly Asn Lys Lys Asn Ala Gly Phe Thr Pro Gln Glu Arg Gln Gly Phe
225 230 235 240
Gly Glu Leu Leu Gln Ala Val Pro Leu Ala Asp Ser Phe Arg His Leu
245 250 255
Tyr Pro Asn Thr Pro Tyr Ala Tyr Thr Phe Trp Thr Tyr Met Met Asn
260 265 270
Ala Arg Ser Lys Asn Val Gly Trp Arg Leu Asp Tyr Phe Leu Leu Ser
275 280 285
His Ser Leu Leu Pro Ala Leu Cys Asp Ser Lys Ile Arg Ser Lys Ala
290 295 300
Leu Gly Ser Asp His Cys Pro Ile Thr Leu Tyr Leu Ala Leu
305 310 315
<210> 69
<211> 263
<212> PRT
<213> 智人(Homo sapiens)
<400> 69
Met Ala Leu Ala Ser Val Leu Glu Arg Pro Leu Pro Val Asn Gln Arg
1 5 10 15
Gly Phe Phe Gly Leu Gly Gly Arg Ala Asp Leu Leu Asp Leu Gly Pro
20 25 30
Gly Ser Leu Ser Asp Gly Leu Ser Leu Ala Ala Pro Gly Trp Gly Val
35 40 45
Pro Glu Glu Pro Gly Ile Glu Met Leu His Gly Thr Thr Thr Leu Ala
50 55 60
Phe Lys Phe Arg His Gly Val Ile Val Ala Ala Asp Ser Arg Ala Thr
65 70 75 80
Ala Gly Ala Tyr Ile Ala Ser Gln Thr Val Lys Lys Val Ile Glu Ile
85 90 95
Asn Pro Tyr Leu Leu Gly Thr Met Ala Gly Gly Ala Ala Asp Cys Ser
100 105 110
Phe Trp Glu Arg Leu Leu Ala Arg Gln Cys Arg Ile Tyr Glu Leu Arg
115 120 125
Asn Lys Glu Arg Ile Ser Val Ala Ala Ala Ser Lys Leu Leu Ala Asn
130 135 140
Met Val Tyr Gln Tyr Lys Gly Met Gly Leu Ser Met Gly Thr Met Ile
145 150 155 160
Cys Gly Trp Asp Lys Arg Gly Pro Gly Leu Tyr Tyr Val Asp Ser Glu
165 170 175
Gly Asn Arg Ile Ser Gly Ala Thr Phe Ser Val Gly Ser Gly Ser Val
180 185 190
Tyr Ala Tyr Gly Val Met Asp Arg Gly Tyr Ser Tyr Asp Leu Glu Val
195 200 205
Glu Gln Ala Tyr Asp Leu Ala Arg Arg Ala Ile Tyr Gln Ala Thr Tyr
210 215 220
Arg Asp Ala Tyr Ser Gly Gly Ala Val Asn Leu Tyr His Val Arg Glu
225 230 235 240
Asp Gly Trp Ile Arg Val Ser Ser Asp Asn Val Ala Asp Leu His Glu
245 250 255
Lys Tyr Ser Gly Ser Thr Pro
260
<210> 70
<211> 105
<212> PRT
<213> 智人(Homo sapiens)
<400> 70
Met Val Lys Gln Ile Glu Ser Lys Thr Ala Phe Gln Glu Ala Leu Asp
1 5 10 15
Ala Ala Gly Asp Lys Leu Val Val Val Asp Phe Ser Ala Thr Trp Cys
20 25 30
Gly Pro Cys Lys Met Ile Lys Pro Phe Phe His Ser Leu Ser Glu Lys
35 40 45
Tyr Ser Asn Val Ile Phe Leu Glu Val Asp Val Asp Asp Cys Gln Asp
50 55 60
Val Ala Ser Glu Cys Glu Val Lys Cys Met Pro Thr Phe Gln Phe Phe
65 70 75 80
Lys Lys Gly Gln Lys Val Gly Glu Phe Ser Gly Ala Asn Lys Glu Lys
85 90 95
Leu Glu Ala Thr Ile Asn Glu Leu Val
100 105
<210> 71
<211> 894
<212> PRT
<213> 智人(Homo sapiens)
<400> 71
Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys
1 5 10 15
Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala
20 25 30
Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg
35 40 45
Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro
50 55 60
Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp
65 70 75 80
Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp
85 90 95
Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr
100 105 110
Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser
115 120 125
Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu
130 135 140
Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys
145 150 155 160
Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp
165 170 175
Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu
180 185 190
His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His
195 200 205
Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu
210 215 220
Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu
225 230 235 240
Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr
245 250 255
His Cys Thr Leu Gln Ala Val Leu Ser Asn Asp Gly Met Gly Ile Gln
260 265 270
Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser
275 280 285
Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro
290 295 300
Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp
305 310 315 320
Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro
325 330 335
Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His
340 345 350
Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg
355 360 365
Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly
370 375 380
Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser
385 390 395 400
Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro
405 410 415
Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln
420 425 430
Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp
435 440 445
Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val
450 455 460
Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg
465 470 475 480
Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val
485 490 495
Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr
500 505 510
Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp
515 520 525
Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu
530 535 540
Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser
545 550 555 560
Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg
565 570 575
Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe
580 585 590
Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser
595 600 605
Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys
610 615 620
His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln
625 630 635 640
Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile
645 650 655
Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp
660 665 670
Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val
675 680 685
Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg
690 695 700
Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser
705 710 715 720
Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly
725 730 735
Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly
740 745 750
Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu
755 760 765
Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg
770 775 780
Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg
785 790 795 800
Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro
805 810 815
Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu
820 825 830
Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro
835 840 845
Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly
850 855 860
Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala
865 870 875 880
Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala
885 890
<210> 72
<211> 208
<212> PRT
<213> 智人(Homo sapiens)
<400> 72
Met Gly Ile Ser Arg Asp Asn Trp His Lys Arg Arg Lys Thr Gly Gly
1 5 10 15
Lys Arg Lys Pro Tyr His Lys Lys Arg Lys Tyr Glu Leu Gly Arg Pro
20 25 30
Ala Ala Asn Thr Lys Ile Gly Pro Arg Arg Ile His Thr Val Arg Val
35 40 45
Arg Gly Gly Asn Lys Lys Tyr Arg Ala Leu Arg Leu Asp Val Gly Asn
50 55 60
Phe Ser Trp Gly Ser Glu Cys Cys Thr Arg Lys Thr Arg Ile Ile Asp
65 70 75 80
Val Val Tyr Asn Ala Ser Asn Asn Glu Leu Val Arg Thr Lys Thr Leu
85 90 95
Val Lys Asn Cys Ile Val Leu Ile Asp Ser Thr Pro Tyr Arg Gln Trp
100 105 110
Tyr Glu Ser His Tyr Ala Leu Pro Leu Gly Arg Lys Lys Gly Ala Lys
115 120 125
Leu Thr Pro Glu Glu Glu Glu Ile Leu Asn Lys Lys Arg Ser Lys Lys
130 135 140
Ile Gln Lys Lys Tyr Asp Glu Arg Lys Lys Asn Ala Lys Ile Ser Ser
145 150 155 160
Leu Leu Glu Glu Gln Phe Gln Gln Gly Lys Leu Leu Ala Cys Ile Ala
165 170 175
Ser Arg Pro Gly Gln Cys Gly Arg Ala Asp Gly Tyr Val Leu Glu Gly
180 185 190
Lys Glu Leu Glu Phe Tyr Leu Arg Lys Ile Lys Ala Arg Lys Gly Lys
195 200 205
<210> 73
<211> 290
<212> PRT
<213> 智人(Homo sapiens)
<400> 73
Met Ala Pro Lys Arg Gln Ser Pro Leu Pro Pro Gln Lys Lys Lys Pro
1 5 10 15
Arg Pro Pro Pro Ala Leu Gly Pro Glu Glu Thr Ser Ala Ser Ala Gly
20 25 30
Leu Pro Lys Lys Gly Glu Lys Glu Gln Gln Glu Ala Ile Glu His Ile
35 40 45
Asp Glu Val Gln Asn Glu Ile Asp Arg Leu Asn Glu Gln Ala Ser Glu
50 55 60
Glu Ile Leu Lys Val Glu Gln Lys Tyr Asn Lys Leu Arg Gln Pro Phe
65 70 75 80
Phe Gln Lys Arg Ser Glu Leu Ile Ala Lys Ile Pro Asn Phe Trp Val
85 90 95
Thr Thr Phe Val Asn His Pro Gln Val Ser Ala Leu Leu Gly Glu Glu
100 105 110
Asp Glu Glu Ala Leu His Tyr Leu Thr Arg Val Glu Val Thr Glu Phe
115 120 125
Glu Asp Ile Lys Ser Gly Tyr Arg Ile Asp Phe Tyr Phe Asp Glu Asn
130 135 140
Pro Tyr Phe Glu Asn Lys Val Leu Ser Lys Glu Phe His Leu Asn Glu
145 150 155 160
Ser Gly Asp Pro Ser Ser Lys Ser Thr Glu Ile Lys Trp Lys Ser Gly
165 170 175
Lys Asp Leu Thr Lys Arg Ser Ser Gln Thr Gln Asn Lys Ala Ser Arg
180 185 190
Lys Arg Gln His Glu Glu Pro Glu Ser Phe Phe Thr Trp Phe Thr Asp
195 200 205
His Ser Asp Ala Gly Ala Asp Glu Leu Gly Glu Val Ile Lys Asp Asp
210 215 220
Ile Trp Pro Asn Pro Leu Gln Tyr Tyr Leu Val Pro Asp Met Asp Asp
225 230 235 240
Glu Glu Gly Glu Gly Glu Glu Asp Asp Asp Asp Asp Glu Glu Glu Glu
245 250 255
Gly Leu Glu Asp Ile Asp Glu Glu Gly Asp Glu Asp Glu Gly Glu Glu
260 265 270
Asp Glu Asp Asp Asp Glu Gly Glu Glu Gly Glu Glu Asp Glu Gly Glu
275 280 285
Asp Asp
290
<210> 74
<211> 152
<212> PRT
<213> 智人(Homo sapiens)
<400> 74
Met Ser Leu Val Ile Pro Glu Lys Phe Gln His Ile Leu Arg Val Leu
1 5 10 15
Asn Thr Asn Ile Asp Gly Arg Arg Lys Ile Ala Phe Ala Ile Thr Ala
20 25 30
Ile Lys Gly Val Gly Arg Arg Tyr Ala His Val Val Leu Arg Lys Ala
35 40 45
Asp Ile Asp Leu Thr Lys Arg Ala Gly Glu Leu Thr Glu Asp Glu Val
50 55 60
Glu Arg Val Ile Thr Ile Met Gln Asn Pro Arg Gln Tyr Lys Ile Pro
65 70 75 80
Asp Trp Phe Leu Asn Arg Gln Lys Asp Val Lys Asp Gly Lys Tyr Ser
85 90 95
Gln Val Leu Ala Asn Gly Leu Asp Asn Lys Leu Arg Glu Asp Leu Glu
100 105 110
Arg Leu Lys Lys Ile Arg Ala His Arg Gly Leu Arg His Phe Trp Gly
115 120 125
Leu Arg Val Arg Gly Gln His Thr Lys Thr Thr Gly Arg Arg Gly Arg
130 135 140
Thr Val Gly Val Ser Lys Lys Lys
145 150
<210> 75
<211> 166
<212> PRT
<213> 智人(Homo sapiens)
<400> 75
Met Ala Ser Gly Val Ala Val Ser Asp Gly Val Ile Lys Val Phe Asn
1 5 10 15
Asp Met Lys Val Arg Lys Ser Ser Thr Pro Glu Glu Val Lys Lys Arg
20 25 30
Lys Lys Ala Val Leu Phe Cys Leu Ser Glu Asp Lys Lys Asn Ile Ile
35 40 45
Leu Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Gln Thr Val
50 55 60
Asp Asp Pro Tyr Ala Thr Phe Val Lys Met Leu Pro Asp Lys Asp Cys
65 70 75 80
Arg Tyr Ala Leu Tyr Asp Ala Thr Tyr Glu Thr Lys Glu Ser Lys Lys
85 90 95
Glu Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys
100 105 110
Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Leu
115 120 125
Thr Gly Ile Lys His Glu Leu Gln Ala Asn Cys Tyr Glu Glu Val Lys
130 135 140
Asp Arg Cys Thr Leu Ala Glu Lys Leu Gly Gly Ser Ala Val Ile Ser
145 150 155 160
Leu Glu Gly Lys Pro Leu
165
<210> 76
<211> 476
<212> PRT
<213> 智人(Homo sapiens)
<400> 76
Met Lys Phe Gln Gly Pro Leu Ala Cys Leu Leu Leu Ala Leu Cys Leu
1 5 10 15
Gly Ser Gly Glu Ala Gly Pro Leu Gln Ser Gly Glu Glu Ser Thr Gly
20 25 30
Thr Asn Ile Gly Glu Ala Leu Gly His Gly Leu Gly Asp Ala Leu Ser
35 40 45
Glu Gly Val Gly Lys Ala Ile Gly Lys Glu Ala Gly Gly Ala Ala Gly
50 55 60
Ser Lys Val Ser Glu Ala Leu Gly Gln Gly Thr Arg Glu Ala Val Gly
65 70 75 80
Thr Gly Val Arg Gln Val Pro Gly Phe Gly Val Ala Asp Ala Leu Gly
85 90 95
Asn Arg Val Gly Glu Ala Ala His Ala Leu Gly Asn Thr Gly His Glu
100 105 110
Ile Gly Arg Gln Ala Glu Asp Val Ile Arg His Gly Ala Asp Ala Val
115 120 125
Arg Gly Ser Trp Gln Gly Val Pro Gly His Asn Gly Ala Trp Glu Thr
130 135 140
Ser Gly Gly His Gly Ile Phe Gly Ser Gln Gly Gly Leu Gly Gly Gln
145 150 155 160
Gly Gln Gly Asn Pro Gly Gly Leu Gly Thr Pro Trp Val His Gly Tyr
165 170 175
Pro Gly Asn Ser Ala Gly Ser Phe Gly Met Asn Pro Gln Gly Ala Pro
180 185 190
Trp Gly Gln Gly Gly Asn Gly Gly Pro Pro Asn Phe Gly Thr Asn Thr
195 200 205
Gln Gly Ala Val Ala Gln Pro Gly Tyr Gly Ser Val Arg Ala Ser Asn
210 215 220
Gln Asn Glu Gly Cys Thr Asn Pro Pro Pro Ser Gly Ser Gly Gly Gly
225 230 235 240
Ser Ser Asn Ser Gly Gly Gly Ser Gly Ser Gln Ser Gly Ser Ser Gly
245 250 255
Ser Gly Ser Asn Gly Asp Asn Asn Asn Gly Ser Ser Ser Gly Gly Ser
260 265 270
Ser Ser Gly Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly
275 280 285
Ser Ser Gly Asn Ser Gly Gly Ser Arg Gly Asp Ser Gly Ser Glu Ser
290 295 300
Ser Trp Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly Ser
305 310 315 320
Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn Glu
325 330 335
Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Asn Ser Glu Thr Ser Pro
340 345 350
Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu
355 360 365
Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro Pro
370 375 380
Ser Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe Lys
385 390 395 400
Gln Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala Asp
405 410 415
Ala Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Asn Tyr Asn
420 425 430
Tyr Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val
435 440 445
Lys Thr Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg
450 455 460
Val Gln Pro Gly Leu Leu Gln Trp Val Lys Phe Trp
465 470 475
<210> 77
<211> 128
<212> PRT
<213> 智人(Homo sapiens)
<400> 77
Met Ala Pro Val Lys Lys Leu Val Val Lys Gly Gly Lys Lys Lys Lys
1 5 10 15
Gln Val Leu Lys Phe Thr Leu Asp Cys Thr His Pro Val Glu Asp Gly
20 25 30
Ile Met Asp Ala Ala Asn Phe Glu Gln Phe Leu Gln Glu Arg Ile Lys
35 40 45
Val Asn Gly Lys Ala Gly Asn Leu Gly Gly Gly Val Val Thr Ile Glu
50 55 60
Arg Ser Lys Ser Lys Ile Thr Val Thr Ser Glu Val Pro Phe Ser Lys
65 70 75 80
Arg Tyr Leu Lys Tyr Leu Thr Lys Lys Tyr Leu Lys Lys Asn Asn Leu
85 90 95
Arg Asp Trp Leu Arg Val Val Ala Asn Ser Lys Glu Ser Tyr Glu Leu
100 105 110
Arg Tyr Phe Gln Ile Asn Gln Asp Glu Glu Glu Glu Glu Asp Glu Asp
115 120 125
<210> 78
<211> 288
<212> PRT
<213> 智人(Homo sapiens)
<400> 78
Met Ala Gly Glu Lys Val Glu Lys Pro Asp Thr Lys Glu Lys Lys Pro
1 5 10 15
Glu Ala Lys Lys Val Asp Ala Gly Gly Lys Val Lys Lys Gly Asn Leu
20 25 30
Lys Ala Lys Lys Pro Lys Lys Gly Lys Pro His Cys Ser Arg Asn Pro
35 40 45
Val Leu Val Arg Gly Ile Gly Arg Tyr Ser Arg Ser Ala Met Tyr Ser
50 55 60
Arg Lys Ala Met Tyr Lys Arg Lys Tyr Ser Ala Ala Lys Ser Lys Val
65 70 75 80
Glu Lys Lys Lys Lys Glu Lys Val Leu Ala Thr Val Thr Lys Pro Val
85 90 95
Gly Gly Asp Lys Asn Gly Gly Thr Arg Val Val Lys Leu Arg Lys Met
100 105 110
Pro Arg Tyr Tyr Pro Thr Glu Asp Val Pro Arg Lys Leu Leu Ser His
115 120 125
Gly Lys Lys Pro Phe Ser Gln His Val Arg Lys Leu Arg Ala Ser Ile
130 135 140
Thr Pro Gly Thr Ile Leu Ile Ile Leu Thr Gly Arg His Arg Gly Lys
145 150 155 160
Arg Val Val Phe Leu Lys Gln Leu Ala Ser Gly Leu Leu Leu Val Thr
165 170 175
Gly Pro Leu Val Leu Asn Arg Val Pro Leu Arg Arg Thr His Gln Lys
180 185 190
Phe Val Ile Ala Thr Ser Thr Lys Ile Asp Ile Ser Asn Val Lys Ile
195 200 205
Pro Lys His Leu Thr Asp Ala Tyr Phe Lys Lys Lys Lys Leu Arg Lys
210 215 220
Pro Arg His Gln Glu Gly Glu Ile Phe Asp Thr Glu Lys Glu Lys Tyr
225 230 235 240
Glu Ile Thr Glu Gln Arg Lys Ile Asp Gln Lys Ala Val Asp Ser Gln
245 250 255
Ile Leu Pro Lys Ile Lys Ala Ile Pro Gln Leu Gln Gly Tyr Leu Arg
260 265 270
Ser Val Phe Ala Leu Thr Asn Gly Ile Tyr Pro His Lys Leu Val Phe
275 280 285
<210> 79
<211> 582
<212> PRT
<213> 智人(Homo sapiens)
<400> 79
Met Phe Pro Ala Gly Pro Pro Ser His Ser Leu Leu Arg Leu Pro Leu
1 5 10 15
Leu Gln Leu Leu Leu Leu Val Val Gln Ala Val Gly Arg Gly Leu Gly
20 25 30
Arg Ala Ser Pro Ala Gly Gly Pro Leu Glu Asp Val Val Ile Glu Arg
35 40 45
Tyr His Ile Pro Arg Ala Cys Pro Arg Glu Val Gln Met Gly Asp Phe
50 55 60
Val Arg Tyr His Tyr Asn Gly Thr Phe Glu Asp Gly Lys Lys Phe Asp
65 70 75 80
Ser Ser Tyr Asp Arg Asn Thr Leu Val Ala Ile Val Val Gly Val Gly
85 90 95
Arg Leu Ile Thr Gly Met Asp Arg Gly Leu Met Gly Met Cys Val Asn
100 105 110
Glu Arg Arg Arg Leu Ile Val Pro Pro His Leu Gly Tyr Gly Ser Ile
115 120 125
Gly Leu Ala Gly Leu Ile Pro Pro Asp Ala Thr Leu Tyr Phe Asp Val
130 135 140
Val Leu Leu Asp Val Trp Asn Lys Glu Asp Thr Val Gln Val Ser Thr
145 150 155 160
Leu Leu Arg Pro Pro His Cys Pro Arg Met Val Gln Asp Gly Asp Phe
165 170 175
Val Arg Tyr His Tyr Asn Gly Thr Leu Leu Asp Gly Thr Ser Phe Asp
180 185 190
Thr Ser Tyr Ser Lys Gly Gly Thr Tyr Asp Thr Tyr Val Gly Ser Gly
195 200 205
Trp Leu Ile Lys Gly Met Asp Gln Gly Leu Leu Gly Met Cys Pro Gly
210 215 220
Glu Arg Arg Lys Ile Ile Ile Pro Pro Phe Leu Ala Tyr Gly Glu Lys
225 230 235 240
Gly Tyr Gly Thr Val Ile Pro Pro Gln Ala Ser Leu Val Phe His Val
245 250 255
Leu Leu Ile Asp Val His Asn Pro Lys Asp Ala Val Gln Leu Glu Thr
260 265 270
Leu Glu Leu Pro Pro Gly Cys Val Arg Arg Ala Gly Ala Gly Asp Phe
275 280 285
Met Arg Tyr His Tyr Asn Gly Ser Leu Met Asp Gly Thr Leu Phe Asp
290 295 300
Ser Ser Tyr Ser Arg Asn His Thr Tyr Asn Thr Tyr Ile Gly Gln Gly
305 310 315 320
Tyr Ile Ile Pro Gly Met Asp Gln Gly Leu Gln Gly Ala Cys Met Gly
325 330 335
Glu Arg Arg Arg Ile Thr Ile Pro Pro His Leu Ala Tyr Gly Glu Asn
340 345 350
Gly Thr Gly Asp Lys Ile Pro Gly Ser Ala Val Leu Ile Phe Asn Val
355 360 365
His Val Ile Asp Phe His Asn Pro Ala Asp Val Val Glu Ile Arg Thr
370 375 380
Leu Ser Arg Pro Ser Glu Thr Cys Asn Glu Thr Thr Lys Leu Gly Asp
385 390 395 400
Phe Val Arg Tyr His Tyr Asn Cys Ser Leu Leu Asp Gly Thr Gln Leu
405 410 415
Phe Thr Ser His Asp Tyr Gly Ala Pro Gln Glu Ala Thr Leu Gly Ala
420 425 430
Asn Lys Val Ile Glu Gly Leu Asp Thr Gly Leu Gln Gly Met Cys Val
435 440 445
Gly Glu Arg Arg Gln Leu Ile Val Pro Pro His Leu Ala His Gly Glu
450 455 460
Ser Gly Ala Arg Gly Val Pro Gly Ser Ala Val Leu Leu Phe Glu Val
465 470 475 480
Glu Leu Val Ser Arg Glu Asp Gly Leu Pro Thr Gly Tyr Leu Phe Val
485 490 495
Trp His Lys Asp Pro Pro Ala Asn Leu Phe Glu Asp Met Asp Leu Asn
500 505 510
Lys Asp Gly Glu Val Pro Pro Glu Glu Phe Ser Thr Phe Ile Lys Ala
515 520 525
Gln Val Ser Glu Gly Lys Gly Arg Leu Met Pro Gly Gln Asp Pro Glu
530 535 540
Lys Thr Ile Gly Asp Met Phe Gln Asn Gln Asp Arg Asn Gln Asp Gly
545 550 555 560
Lys Ile Thr Val Asp Glu Leu Lys Leu Lys Ser Asp Glu Asp Glu Glu
565 570 575
Arg Val His Glu Glu Leu
580
<210> 80
<211> 410
<212> PRT
<213> 智人(Homo sapiens)
<400> 80
Met Val Leu Ser Gln Arg Gln Arg Asp Glu Leu Asn Arg Ala Ile Ala
1 5 10 15
Asp Tyr Leu Arg Ser Asn Gly Tyr Glu Glu Ala Tyr Ser Val Phe Lys
20 25 30
Lys Glu Ala Glu Leu Asp Val Asn Glu Glu Leu Asp Lys Lys Tyr Ala
35 40 45
Gly Leu Leu Glu Lys Lys Trp Thr Ser Val Ile Arg Leu Gln Lys Lys
50 55 60
Val Met Glu Leu Glu Ser Lys Leu Asn Glu Ala Lys Glu Glu Phe Thr
65 70 75 80
Ser Gly Gly Pro Leu Gly Gln Lys Arg Asp Pro Lys Glu Trp Ile Pro
85 90 95
Arg Pro Pro Glu Lys Tyr Ala Leu Ser Gly His Arg Ser Pro Val Thr
100 105 110
Arg Val Ile Phe His Pro Val Phe Ser Val Met Val Ser Ala Ser Glu
115 120 125
Asp Ala Thr Ile Lys Val Trp Asp Tyr Glu Thr Gly Asp Phe Glu Arg
130 135 140
Thr Leu Lys Gly His Thr Asp Ser Val Gln Asp Ile Ser Phe Asp His
145 150 155 160
Ser Gly Lys Leu Leu Ala Ser Cys Ser Ala Asp Met Thr Ile Lys Leu
165 170 175
Trp Asp Phe Gln Gly Phe Glu Cys Ile Arg Thr Met His Gly His Asp
180 185 190
His Asn Val Ser Ser Val Ala Ile Met Pro Asn Gly Asp His Ile Val
195 200 205
Ser Ala Ser Arg Asp Lys Thr Ile Lys Met Trp Glu Val Gln Thr Gly
210 215 220
Tyr Cys Val Lys Thr Phe Thr Gly His Arg Glu Trp Val Arg Met Val
225 230 235 240
Arg Pro Asn Gln Asp Gly Thr Leu Ile Ala Ser Cys Ser Asn Asp Gln
245 250 255
Thr Val Arg Val Trp Val Val Ala Thr Lys Glu Cys Lys Ala Glu Leu
260 265 270
Arg Glu His Glu His Val Val Glu Cys Ile Ser Trp Ala Pro Glu Ser
275 280 285
Ser Tyr Ser Ser Ile Ser Glu Ala Thr Gly Ser Glu Thr Lys Lys Ser
290 295 300
Gly Lys Pro Gly Pro Phe Leu Leu Ser Gly Ser Arg Asp Lys Thr Ile
305 310 315 320
Lys Met Trp Asp Val Ser Thr Gly Met Cys Leu Met Thr Leu Val Gly
325 330 335
His Asp Asn Trp Val Arg Gly Val Leu Phe His Ser Gly Gly Lys Phe
340 345 350
Ile Leu Ser Cys Ala Asp Asp Lys Thr Leu Arg Val Trp Asp Tyr Lys
355 360 365
Asn Lys Arg Cys Met Lys Thr Leu Asn Ala His Glu His Phe Val Thr
370 375 380
Ser Leu Asp Phe His Lys Thr Ala Pro Tyr Val Val Thr Gly Ser Val
385 390 395 400
Asp Gln Thr Val Lys Val Trp Glu Cys Arg
405 410
<210> 81
<211> 98
<212> PRT
<213> 智人(Homo sapiens)
<400> 81
Met Ala Ala Glu Pro Leu Thr Glu Leu Glu Glu Ser Ile Glu Thr Val
1 5 10 15
Val Thr Thr Phe Phe Thr Phe Ala Arg Gln Glu Gly Arg Lys Asp Ser
20 25 30
Leu Ser Val Asn Glu Phe Lys Glu Leu Val Thr Gln Gln Leu Pro His
35 40 45
Leu Leu Lys Asp Val Gly Ser Leu Asp Glu Lys Met Lys Ser Leu Asp
50 55 60
Val Asn Gln Asp Ser Glu Leu Lys Phe Asn Glu Tyr Trp Arg Leu Ile
65 70 75 80
Gly Glu Leu Ala Lys Glu Ile Arg Lys Lys Lys Asp Leu Lys Ile Arg
85 90 95
Lys Lys
<210> 82
<211> 246
<212> PRT
<213> 智人(Homo sapiens)
<400> 82
Met Ser Arg Gly Ser Ser Ala Gly Phe Asp Arg His Ile Thr Ile Phe
1 5 10 15
Ser Pro Glu Gly Arg Leu Tyr Gln Val Glu Tyr Ala Phe Lys Ala Ile
20 25 30
Asn Gln Gly Gly Leu Thr Ser Val Ala Val Arg Gly Lys Asp Cys Ala
35 40 45
Val Ile Val Thr Gln Lys Lys Val Pro Asp Lys Leu Leu Asp Ser Ser
50 55 60
Thr Val Thr His Leu Phe Lys Ile Thr Glu Asn Ile Gly Cys Val Met
65 70 75 80
Thr Gly Met Thr Ala Asp Ser Arg Ser Gln Val Gln Arg Ala Arg Tyr
85 90 95
Glu Ala Ala Asn Trp Lys Tyr Lys Tyr Gly Tyr Glu Ile Pro Val Asp
100 105 110
Met Leu Cys Lys Arg Ile Ala Asp Ile Ser Gln Val Tyr Thr Gln Asn
115 120 125
Ala Glu Met Arg Pro Leu Gly Cys Cys Met Ile Leu Ile Gly Ile Asp
130 135 140
Glu Glu Gln Gly Pro Gln Val Tyr Lys Cys Asp Pro Ala Gly Tyr Tyr
145 150 155 160
Cys Gly Phe Lys Ala Thr Ala Ala Gly Val Lys Gln Thr Glu Ser Thr
165 170 175
Ser Phe Leu Glu Lys Lys Val Lys Lys Lys Phe Asp Trp Thr Phe Glu
180 185 190
Gln Thr Val Glu Thr Ala Ile Thr Cys Leu Ser Thr Val Leu Ser Ile
195 200 205
Asp Phe Lys Pro Ser Glu Ile Glu Val Gly Val Val Thr Val Glu Asn
210 215 220
Pro Lys Phe Arg Ile Leu Thr Glu Ala Glu Ile Asp Ala His Leu Val
225 230 235 240
Ala Leu Ala Glu Arg Asp
245
<210> 83
<211> 402
<212> PRT
<213> 智人(Homo sapiens)
<400> 83
Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu
1 5 10 15
Val Phe Gly Glu Gly Ser Ala Val His His Pro Pro Ser Tyr Val Ala
20 25 30
His Leu Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln
35 40 45
Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser
50 55 60
Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln
65 70 75 80
Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro
85 90 95
Ala Leu Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp
100 105 110
Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu
115 120 125
Val Gln Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val
130 135 140
Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn
145 150 155 160
Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu Gly
165 170 175
Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu
180 185 190
Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His
195 200 205
Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met
210 215 220
Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp
225 230 235 240
Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu
245 250 255
Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala
260 265 270
Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn
275 280 285
Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu
290 295 300
Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp
305 310 315 320
Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu
325 330 335
Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn
340 345 350
Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala
355 360 365
Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val
370 375 380
Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met
385 390 395 400
Glu Pro
<210> 84
<211> 709
<212> PRT
<213> 智人(Homo sapiens)
<400> 84
Met Pro Ser Ala Thr Ser His Ser Gly Ser Gly Ser Lys Ser Ser Gly
1 5 10 15
Pro Pro Pro Pro Ser Gly Ser Ser Gly Ser Glu Ala Ala Ala Gly Ala
20 25 30
Gly Ala Ala Ala Pro Ala Ser Gln His Pro Ala Thr Gly Thr Gly Ala
35 40 45
Val Gln Thr Glu Ala Met Lys Gln Ile Leu Gly Val Ile Asp Lys Lys
50 55 60
Leu Arg Asn Leu Glu Lys Lys Lys Gly Lys Leu Asp Asp Tyr Gln Glu
65 70 75 80
Arg Met Asn Lys Gly Glu Arg Leu Asn Gln Asp Gln Leu Asp Ala Val
85 90 95
Ser Lys Tyr Gln Glu Val Thr Asn Asn Leu Glu Phe Ala Lys Glu Leu
100 105 110
Gln Arg Ser Phe Met Ala Leu Ser Gln Asp Ile Gln Lys Thr Ile Lys
115 120 125
Lys Thr Ala Arg Arg Glu Gln Leu Met Arg Glu Glu Ala Glu Gln Lys
130 135 140
Arg Leu Lys Thr Val Leu Glu Leu Gln Tyr Val Leu Asp Lys Leu Gly
145 150 155 160
Asp Asp Glu Val Arg Thr Asp Leu Lys Gln Gly Leu Asn Gly Val Pro
165 170 175
Ile Leu Ser Glu Glu Glu Leu Ser Leu Leu Asp Glu Phe Tyr Lys Leu
180 185 190
Val Asp Pro Glu Arg Asp Met Ser Leu Arg Leu Asn Glu Gln Tyr Glu
195 200 205
His Ala Ser Ile His Leu Trp Asp Leu Leu Glu Gly Lys Glu Lys Pro
210 215 220
Val Cys Gly Thr Thr Tyr Lys Val Leu Lys Glu Ile Val Glu Arg Val
225 230 235 240
Phe Gln Ser Asn Tyr Phe Asp Ser Thr His Asn His Gln Asn Gly Leu
245 250 255
Cys Glu Glu Glu Glu Ala Ala Ser Ala Pro Ala Val Glu Asp Gln Val
260 265 270
Pro Glu Ala Glu Pro Glu Pro Ala Glu Glu Tyr Thr Glu Gln Ser Glu
275 280 285
Val Glu Ser Thr Glu Tyr Val Asn Arg Gln Phe Met Ala Glu Thr Gln
290 295 300
Phe Thr Ser Gly Glu Lys Glu Gln Val Asp Glu Trp Thr Val Glu Thr
305 310 315 320
Val Glu Val Val Asn Ser Leu Gln Gln Gln Pro Gln Ala Ala Ser Pro
325 330 335
Ser Val Pro Glu Pro His Ser Leu Thr Pro Val Ala Gln Ala Asp Pro
340 345 350
Leu Val Arg Arg Gln Arg Val Gln Asp Leu Met Ala Gln Met Gln Gly
355 360 365
Pro Tyr Asn Phe Ile Gln Asp Ser Met Leu Asp Phe Glu Asn Gln Thr
370 375 380
Leu Asp Pro Ala Ile Val Ser Ala Gln Pro Met Asn Pro Thr Gln Asn
385 390 395 400
Met Asp Met Pro Gln Leu Val Cys Pro Pro Val His Ser Glu Ser Arg
405 410 415
Leu Ala Gln Pro Asn Gln Val Pro Val Gln Pro Glu Ala Thr Gln Val
420 425 430
Pro Leu Val Ser Ser Thr Ser Glu Gly Tyr Thr Ala Ser Gln Pro Leu
435 440 445
Tyr Gln Pro Ser His Ala Thr Glu Gln Arg Pro Gln Lys Glu Pro Ile
450 455 460
Asp Gln Ile Gln Ala Thr Ile Ser Leu Asn Thr Asp Gln Thr Thr Ala
465 470 475 480
Ser Ser Ser Leu Pro Ala Ala Ser Gln Pro Gln Val Phe Gln Ala Gly
485 490 495
Thr Ser Lys Pro Leu His Ser Ser Gly Ile Asn Val Asn Ala Ala Pro
500 505 510
Phe Gln Ser Met Gln Thr Val Phe Asn Met Asn Ala Pro Val Pro Pro
515 520 525
Val Asn Glu Pro Glu Thr Leu Lys Gln Gln Asn Gln Tyr Gln Ala Ser
530 535 540
Tyr Asn Gln Ser Phe Ser Ser Gln Pro His Gln Val Glu Gln Thr Glu
545 550 555 560
Leu Gln Gln Glu Gln Leu Gln Thr Val Val Gly Thr Tyr His Gly Ser
565 570 575
Pro Asp Gln Ser His Gln Val Thr Gly Asn His Gln Gln Pro Pro Gln
580 585 590
Gln Asn Thr Gly Phe Pro Arg Ser Asn Gln Pro Tyr Tyr Asn Ser Arg
595 600 605
Gly Val Ser Arg Gly Gly Ser Arg Gly Ala Arg Gly Leu Met Asn Gly
610 615 620
Tyr Arg Gly Pro Ala Asn Gly Phe Arg Gly Gly Tyr Asp Gly Tyr Arg
625 630 635 640
Pro Ser Phe Ser Asn Thr Pro Asn Ser Gly Tyr Thr Gln Ser Gln Phe
645 650 655
Ser Ala Pro Arg Asp Tyr Ser Gly Tyr Gln Arg Asp Gly Tyr Gln Gln
660 665 670
Asn Phe Lys Arg Gly Ser Gly Gln Ser Gly Pro Arg Gly Ala Pro Arg
675 680 685
Gly Arg Gly Gly Pro Pro Arg Pro Asn Arg Gly Met Pro Gln Met Asn
690 695 700
Thr Gln Gln Val Asn
705
<210> 85
<211> 437
<212> PRT
<213> 智人(Homo sapiens)
<400> 85
Met Ser Val Ser Ala Arg Ser Ala Ala Ala Glu Glu Arg Ser Val Asn
1 5 10 15
Ser Ser Thr Met Val Ala Gln Gln Lys Asn Leu Glu Gly Tyr Val Gly
20 25 30
Phe Ala Asn Leu Pro Asn Gln Val Tyr Arg Lys Ser Val Lys Arg Gly
35 40 45
Phe Glu Phe Thr Leu Met Val Val Gly Glu Ser Gly Leu Gly Lys Ser
50 55 60
Thr Leu Ile Asn Ser Leu Phe Leu Thr Asp Leu Tyr Ser Pro Glu Tyr
65 70 75 80
Pro Gly Pro Ser His Arg Ile Lys Lys Thr Val Gln Val Glu Gln Ser
85 90 95
Lys Val Leu Ile Lys Glu Gly Gly Val Gln Leu Leu Leu Thr Ile Val
100 105 110
Asp Thr Pro Gly Phe Gly Asp Ala Val Asp Asn Ser Asn Cys Trp Gln
115 120 125
Pro Val Ile Asp Tyr Ile Asp Ser Lys Phe Glu Asp Tyr Leu Asn Ala
130 135 140
Glu Ser Arg Val Asn Arg Arg Gln Met Pro Asp Asn Arg Val Gln Cys
145 150 155 160
Cys Leu Tyr Phe Ile Ala Pro Ser Gly His Gly Leu Lys Pro Leu Asp
165 170 175
Ile Glu Phe Met Lys Arg Leu His Glu Lys Val Asn Ile Ile Pro Leu
180 185 190
Ile Ala Lys Ala Asp Thr Leu Thr Pro Glu Glu Cys Gln Gln Phe Lys
195 200 205
Lys Gln Ile Met Lys Glu Ile Gln Glu His Lys Ile Lys Ile Tyr Glu
210 215 220
Phe Pro Glu Thr Asp Asp Glu Glu Glu Asn Lys Leu Val Lys Lys Ile
225 230 235 240
Lys Asp Arg Leu Pro Leu Ala Val Val Gly Ser Asn Thr Ile Ile Glu
245 250 255
Val Asn Gly Lys Arg Val Arg Gly Arg Gln Tyr Pro Trp Gly Val Ala
260 265 270
Glu Val Glu Asn Gly Glu His Cys Asp Phe Thr Ile Leu Arg Asn Met
275 280 285
Leu Ile Arg Thr His Met Gln Asp Leu Lys Asp Val Thr Asn Asn Val
290 295 300
His Tyr Glu Asn Tyr Arg Ser Arg Lys Leu Ala Ala Val Thr Tyr Asn
305 310 315 320
Gly Val Asp Asn Asn Lys Asn Lys Gly Gln Leu Thr Lys Ser Pro Leu
325 330 335
Ala Gln Met Glu Glu Glu Arg Arg Glu His Val Ala Lys Met Lys Lys
340 345 350
Met Glu Met Glu Met Glu Gln Val Phe Glu Met Lys Val Lys Glu Lys
355 360 365
Val Gln Lys Leu Lys Asp Ser Glu Ala Glu Leu Gln Arg Arg His Glu
370 375 380
Gln Met Lys Lys Asn Leu Glu Ala Gln His Lys Glu Leu Glu Glu Lys
385 390 395 400
Arg Arg Gln Phe Glu Asp Glu Lys Ala Asn Trp Glu Ala Gln Gln Arg
405 410 415
Ile Leu Glu Gln Gln Asn Ser Ser Arg Thr Leu Glu Lys Asn Lys Lys
420 425 430
Lys Gly Lys Ile Phe
435
<210> 86
<211> 478
<212> PRT
<213> 智人(Homo sapiens)
<400> 86
Met Ala Pro Leu Arg Pro Leu Leu Ile Leu Ala Leu Leu Ala Trp Val
1 5 10 15
Ala Leu Ala Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe
20 25 30
Asn Val Asp Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln
35 40 45
Ser Cys Cys Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Arg
50 55 60
Gly Asp Val Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp
65 70 75 80
Gly Glu Glu Lys Asn Asn Ala Thr Val His Glu Gln Val Gly Gly Pro
85 90 95
Ser Leu Thr Ser Asp Leu Gln Ala Gln Ser Lys Gly Asn Pro Glu Gln
100 105 110
Thr Pro Val Leu Lys Pro Glu Glu Glu Ala Pro Ala Pro Glu Val Gly
115 120 125
Ala Ser Lys Pro Glu Gly Ile Asp Ser Arg Pro Glu Thr Leu His Pro
130 135 140
Gly Arg Pro Gln Pro Pro Ala Glu Glu Glu Leu Cys Ser Gly Lys Pro
145 150 155 160
Phe Asp Ala Phe Thr Asp Leu Lys Asn Gly Ser Leu Phe Ala Phe Arg
165 170 175
Gly Gln Tyr Cys Tyr Glu Leu Asp Glu Lys Ala Val Arg Pro Gly Tyr
180 185 190
Pro Lys Leu Ile Arg Asp Val Trp Gly Ile Glu Gly Pro Ile Asp Ala
195 200 205
Ala Phe Thr Arg Ile Asn Cys Gln Gly Lys Thr Tyr Leu Phe Lys Gly
210 215 220
Ser Gln Tyr Trp Arg Phe Glu Asp Gly Val Leu Asp Pro Asp Tyr Pro
225 230 235 240
Arg Asn Ile Ser Asp Gly Phe Asp Gly Ile Pro Asp Asn Val Asp Ala
245 250 255
Ala Leu Ala Leu Pro Ala His Ser Tyr Ser Gly Arg Glu Arg Val Tyr
260 265 270
Phe Phe Lys Gly Lys Gln Tyr Trp Glu Tyr Gln Phe Gln His Gln Pro
275 280 285
Ser Gln Glu Glu Cys Glu Gly Ser Ser Leu Ser Ala Val Phe Glu His
290 295 300
Phe Ala Met Met Gln Arg Asp Ser Trp Glu Asp Ile Phe Glu Leu Leu
305 310 315 320
Phe Trp Gly Arg Thr Ser Ala Gly Thr Arg Gln Pro Gln Phe Ile Ser
325 330 335
Arg Asp Trp His Gly Val Pro Gly Gln Val Asp Ala Ala Met Ala Gly
340 345 350
Arg Ile Tyr Ile Ser Gly Met Ala Pro Arg Pro Ser Leu Ala Lys Lys
355 360 365
Gln Arg Phe Arg His Arg Asn Arg Lys Gly Tyr Arg Ser Gln Arg Gly
370 375 380
His Ser Arg Gly Arg Asn Gln Asn Ser Arg Arg Pro Ser Arg Ala Thr
385 390 395 400
Trp Leu Ser Leu Phe Ser Ser Glu Glu Ser Asn Leu Gly Ala Asn Asn
405 410 415
Tyr Asp Asp Tyr Arg Met Asp Trp Leu Val Pro Ala Thr Cys Glu Pro
420 425 430
Ile Gln Ser Val Phe Phe Phe Ser Gly Asp Lys Tyr Tyr Arg Val Asn
435 440 445
Leu Arg Thr Arg Arg Val Asp Thr Val Asp Pro Pro Tyr Pro Arg Ser
450 455 460
Ile Ala Gln Tyr Trp Leu Gly Cys Pro Ala Pro Gly His Leu
465 470 475
<210> 87
<211> 863
<212> PRT
<213> 智人(Homo sapiens)
<400> 87
Met Ala Arg Arg Ser Ser Phe Gln Ser Cys Gln Ile Ile Ser Leu Phe
1 5 10 15
Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala His Arg
20 25 30
Ile Lys Arg Ala Glu Gly Trp Glu Glu Gly Pro Pro Thr Val Leu Ser
35 40 45
Asp Ser Pro Trp Thr Asn Ile Ser Gly Ser Cys Lys Gly Arg Cys Phe
50 55 60
Glu Leu Gln Glu Ala Gly Pro Pro Asp Cys Arg Cys Asp Asn Leu Cys
65 70 75 80
Lys Ser Tyr Thr Ser Cys Cys His Asp Phe Asp Glu Leu Cys Leu Lys
85 90 95
Thr Ala Arg Gly Trp Glu Cys Thr Lys Asp Arg Cys Gly Glu Val Arg
100 105 110
Asn Glu Glu Asn Ala Cys His Cys Ser Glu Asp Cys Leu Ala Arg Gly
115 120 125
Asp Cys Cys Thr Asn Tyr Gln Val Val Cys Lys Gly Glu Ser His Trp
130 135 140
Val Asp Asp Asp Cys Glu Glu Ile Lys Ala Ala Glu Cys Pro Ala Gly
145 150 155 160
Phe Val Arg Pro Pro Leu Ile Ile Phe Ser Val Asp Gly Phe Arg Ala
165 170 175
Ser Tyr Met Lys Lys Gly Ser Lys Val Met Pro Asn Ile Glu Lys Leu
180 185 190
Arg Ser Cys Gly Thr His Ser Pro Tyr Met Arg Pro Val Tyr Pro Thr
195 200 205
Lys Thr Phe Pro Asn Leu Tyr Thr Leu Ala Thr Gly Leu Tyr Pro Glu
210 215 220
Ser His Gly Ile Val Gly Asn Ser Met Tyr Asp Pro Val Phe Asp Ala
225 230 235 240
Thr Phe His Leu Arg Gly Arg Glu Lys Phe Asn His Arg Trp Trp Gly
245 250 255
Gly Gln Pro Leu Trp Ile Thr Ala Thr Lys Gln Gly Val Lys Ala Gly
260 265 270
Thr Phe Phe Trp Ser Val Val Ile Pro His Glu Arg Arg Ile Leu Thr
275 280 285
Ile Leu Gln Trp Leu Thr Leu Pro Asp His Glu Arg Pro Ser Val Tyr
290 295 300
Ala Phe Tyr Ser Glu Gln Pro Asp Phe Ser Gly His Lys Tyr Gly Pro
305 310 315 320
Phe Gly Pro Glu Met Thr Asn Pro Leu Arg Glu Ile Asp Lys Ile Val
325 330 335
Gly Gln Leu Met Asp Gly Leu Lys Gln Leu Lys Leu His Arg Cys Val
340 345 350
Asn Val Ile Phe Val Gly Asp His Gly Met Glu Asp Val Thr Cys Asp
355 360 365
Arg Thr Glu Phe Leu Ser Asn Tyr Leu Thr Asn Val Asp Asp Ile Thr
370 375 380
Leu Val Pro Gly Thr Leu Gly Arg Ile Arg Ser Lys Phe Ser Asn Asn
385 390 395 400
Ala Lys Tyr Asp Pro Lys Ala Ile Ile Ala Asn Leu Thr Cys Lys Lys
405 410 415
Pro Asp Gln His Phe Lys Pro Tyr Leu Lys Gln His Leu Pro Lys Arg
420 425 430
Leu His Tyr Ala Asn Asn Arg Arg Ile Glu Asp Ile His Leu Leu Val
435 440 445
Glu Arg Arg Trp His Val Ala Arg Lys Pro Leu Asp Val Tyr Lys Lys
450 455 460
Pro Ser Gly Lys Cys Phe Phe Gln Gly Asp His Gly Phe Asp Asn Lys
465 470 475 480
Val Asn Ser Met Gln Thr Val Phe Val Gly Tyr Gly Ser Thr Phe Lys
485 490 495
Tyr Lys Thr Lys Val Pro Pro Phe Glu Asn Ile Glu Leu Tyr Asn Val
500 505 510
Met Cys Asp Leu Leu Gly Leu Lys Pro Ala Pro Asn Asn Gly Thr His
515 520 525
Gly Ser Leu Asn His Leu Leu Arg Thr Asn Thr Phe Arg Pro Thr Met
530 535 540
Pro Glu Glu Val Thr Arg Pro Asn Tyr Pro Gly Ile Met Tyr Leu Gln
545 550 555 560
Ser Asp Phe Asp Leu Gly Cys Thr Cys Asp Asp Lys Val Glu Pro Lys
565 570 575
Asn Lys Leu Asp Glu Leu Asn Lys Arg Leu His Thr Lys Gly Ser Thr
580 585 590
Glu Glu Arg His Leu Leu Tyr Gly Arg Pro Ala Val Leu Tyr Arg Thr
595 600 605
Arg Tyr Asp Ile Leu Tyr His Thr Asp Phe Glu Ser Gly Tyr Ser Glu
610 615 620
Ile Phe Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Ser Lys Gln Ala
625 630 635 640
Glu Val Ser Ser Val Pro Asp His Leu Thr Ser Cys Val Arg Pro Asp
645 650 655
Val Arg Val Ser Pro Ser Phe Ser Gln Asn Cys Leu Ala Tyr Lys Asn
660 665 670
Asp Lys Gln Met Ser Tyr Gly Phe Leu Phe Pro Pro Tyr Leu Ser Ser
675 680 685
Ser Pro Glu Ala Lys Tyr Asp Ala Phe Leu Val Thr Asn Met Val Pro
690 695 700
Met Tyr Pro Ala Phe Lys Arg Val Trp Asn Tyr Phe Gln Arg Val Leu
705 710 715 720
Val Lys Lys Tyr Ala Ser Glu Arg Asn Gly Val Asn Val Ile Ser Gly
725 730 735
Pro Ile Phe Asp Tyr Asp Tyr Asp Gly Leu His Asp Thr Glu Asp Lys
740 745 750
Ile Lys Gln Tyr Val Glu Gly Ser Ser Ile Pro Val Pro Thr His Tyr
755 760 765
Tyr Ser Ile Ile Thr Ser Cys Leu Asp Phe Thr Gln Pro Ala Asp Lys
770 775 780
Cys Asp Gly Pro Leu Ser Val Ser Ser Phe Ile Leu Pro His Arg Pro
785 790 795 800
Asp Asn Glu Glu Ser Cys Asn Ser Ser Glu Asp Glu Ser Lys Trp Val
805 810 815
Glu Glu Leu Met Lys Met His Thr Ala Arg Val Arg Asp Ile Glu His
820 825 830
Leu Thr Ser Leu Asp Phe Phe Arg Lys Thr Ser Arg Ser Tyr Pro Glu
835 840 845
Ile Leu Thr Leu Lys Thr Tyr Leu His Thr Tyr Glu Ser Glu Ile
850 855 860
<210> 88
<211> 1461
<212> PRT
<213> 智人(Homo sapiens)
<400> 88
Met Ala Ala Glu Arg Gly Ala Arg Arg Leu Leu Ser Thr Pro Ser Phe
1 5 10 15
Trp Leu Tyr Cys Leu Leu Leu Leu Gly Arg Arg Ala Pro Gly Ala Ala
20 25 30
Ala Ala Arg Ser Gly Ser Ala Pro Gln Ser Pro Gly Ala Ser Ile Arg
35 40 45
Thr Phe Thr Pro Phe Tyr Phe Leu Val Glu Pro Val Asp Thr Leu Ser
50 55 60
Val Arg Gly Ser Ser Val Ile Leu Asn Cys Ser Ala Tyr Ser Glu Pro
65 70 75 80
Ser Pro Lys Ile Glu Trp Lys Lys Asp Gly Thr Phe Leu Asn Leu Val
85 90 95
Ser Asp Asp Arg Arg Gln Leu Leu Pro Asp Gly Ser Leu Phe Ile Ser
100 105 110
Asn Val Val His Ser Lys His Asn Lys Pro Asp Glu Gly Tyr Tyr Gln
115 120 125
Cys Val Ala Thr Val Glu Ser Leu Gly Thr Ile Ile Ser Arg Thr Ala
130 135 140
Lys Leu Ile Val Ala Gly Leu Pro Arg Phe Thr Ser Gln Pro Glu Pro
145 150 155 160
Ser Ser Val Tyr Ala Gly Asn Asn Ala Ile Leu Asn Cys Glu Val Asn
165 170 175
Ala Asp Leu Val Pro Phe Val Arg Trp Glu Gln Asn Arg Gln Pro Leu
180 185 190
Leu Leu Asp Asp Arg Val Ile Lys Leu Pro Ser Gly Met Leu Val Ile
195 200 205
Ser Asn Ala Thr Glu Gly Asp Gly Gly Leu Tyr Arg Cys Val Val Glu
210 215 220
Ser Gly Gly Pro Pro Lys Tyr Ser Asp Glu Val Glu Leu Lys Val Leu
225 230 235 240
Pro Asp Pro Glu Val Ile Ser Asp Leu Val Phe Leu Lys Gln Pro Ser
245 250 255
Pro Leu Val Arg Val Ile Gly Gln Asp Val Val Leu Pro Cys Val Ala
260 265 270
Ser Gly Leu Pro Thr Pro Thr Ile Lys Trp Met Lys Asn Glu Glu Ala
275 280 285
Leu Asp Thr Glu Ser Ser Glu Arg Leu Val Leu Leu Ala Gly Gly Ser
290 295 300
Leu Glu Ile Ser Asp Val Thr Glu Asp Asp Ala Gly Thr Tyr Phe Cys
305 310 315 320
Ile Ala Asp Asn Gly Asn Glu Thr Ile Glu Ala Gln Ala Glu Leu Thr
325 330 335
Val Gln Ala Gln Pro Glu Phe Leu Lys Gln Pro Thr Asn Ile Tyr Ala
340 345 350
His Glu Ser Met Asp Ile Val Phe Glu Cys Glu Val Thr Gly Lys Pro
355 360 365
Thr Pro Thr Val Lys Trp Val Lys Asn Gly Asp Met Val Ile Pro Ser
370 375 380
Asp Tyr Phe Lys Ile Val Lys Glu His Asn Leu Gln Val Leu Gly Leu
385 390 395 400
Val Lys Ser Asp Glu Gly Phe Tyr Gln Cys Ile Ala Glu Asn Asp Val
405 410 415
Gly Asn Ala Gln Ala Gly Ala Gln Leu Ile Ile Leu Glu His Ala Pro
420 425 430
Ala Thr Thr Gly Pro Leu Pro Ser Ala Pro Arg Asp Val Val Ala Ser
435 440 445
Leu Val Ser Thr Arg Phe Ile Lys Leu Thr Trp Arg Thr Pro Ala Ser
450 455 460
Asp Pro His Gly Asp Asn Leu Thr Tyr Ser Val Phe Tyr Thr Lys Glu
465 470 475 480
Gly Ile Ala Arg Glu Arg Val Glu Asn Thr Ser His Pro Gly Glu Met
485 490 495
Gln Val Thr Ile Gln Asn Leu Met Pro Ala Thr Val Tyr Ile Phe Arg
500 505 510
Val Met Ala Gln Asn Lys His Gly Ser Gly Glu Ser Ser Ala Pro Leu
515 520 525
Arg Val Glu Thr Gln Pro Glu Val Gln Leu Pro Gly Pro Ala Pro Asn
530 535 540
Leu Arg Ala Tyr Ala Ala Ser Pro Thr Ser Ile Thr Val Thr Trp Glu
545 550 555 560
Thr Pro Val Ser Gly Asn Gly Glu Ile Gln Asn Tyr Lys Leu Tyr Tyr
565 570 575
Met Glu Lys Gly Thr Asp Lys Glu Gln Asp Val Asp Val Ser Ser His
580 585 590
Ser Tyr Thr Ile Asn Gly Leu Lys Lys Tyr Thr Glu Tyr Ser Phe Arg
595 600 605
Val Val Ala Tyr Asn Lys His Gly Pro Gly Val Ser Thr Pro Asp Val
610 615 620
Ala Val Arg Thr Leu Ser Asp Val Pro Ser Ala Ala Pro Gln Asn Leu
625 630 635 640
Ser Leu Glu Val Arg Asn Ser Lys Ser Ile Met Ile His Trp Gln Pro
645 650 655
Pro Ala Pro Ala Thr Gln Asn Gly Gln Ile Thr Gly Tyr Lys Ile Arg
660 665 670
Tyr Arg Lys Ala Ser Arg Lys Ser Asp Val Thr Glu Thr Leu Val Ser
675 680 685
Gly Thr Gln Leu Ser Gln Leu Ile Glu Gly Leu Asp Arg Gly Thr Glu
690 695 700
Tyr Asn Phe Arg Val Ala Ala Leu Thr Ile Asn Gly Thr Gly Pro Ala
705 710 715 720
Thr Asp Trp Leu Ser Ala Glu Thr Phe Glu Ser Asp Leu Asp Glu Thr
725 730 735
Arg Val Pro Glu Val Pro Ser Ser Leu His Val Arg Pro Leu Val Thr
740 745 750
Ser Ile Val Val Ser Trp Thr Pro Pro Glu Asn Gln Asn Ile Val Val
755 760 765
Arg Gly Tyr Ala Ile Gly Tyr Gly Ile Gly Ser Pro His Ala Gln Thr
770 775 780
Ile Lys Val Asp Tyr Lys Gln Arg Tyr Tyr Thr Ile Glu Asn Leu Asp
785 790 795 800
Pro Ser Ser His Tyr Val Ile Thr Leu Lys Ala Phe Asn Asn Val Gly
805 810 815
Glu Gly Ile Pro Leu Tyr Glu Ser Ala Val Thr Arg Pro His Thr Asp
820 825 830
Thr Ser Glu Val Asp Leu Phe Val Ile Asn Ala Pro Tyr Thr Pro Val
835 840 845
Pro Asp Pro Thr Pro Met Met Pro Pro Val Gly Val Gln Ala Ser Ile
850 855 860
Leu Ser His Asp Thr Ile Arg Ile Thr Trp Ala Asp Asn Ser Leu Pro
865 870 875 880
Lys His Gln Lys Ile Thr Asp Ser Arg Tyr Tyr Thr Val Arg Trp Lys
885 890 895
Thr Asn Ile Pro Ala Asn Thr Lys Tyr Lys Asn Ala Asn Ala Thr Thr
900 905 910
Leu Ser Tyr Leu Val Thr Gly Leu Lys Pro Asn Thr Leu Tyr Glu Phe
915 920 925
Ser Val Met Val Thr Lys Gly Arg Arg Ser Ser Thr Trp Ser Met Thr
930 935 940
Ala His Gly Thr Thr Phe Glu Leu Val Pro Thr Ser Pro Pro Lys Asp
945 950 955 960
Val Thr Val Val Ser Lys Glu Gly Lys Pro Lys Thr Ile Ile Val Asn
965 970 975
Trp Gln Pro Pro Ser Glu Ala Asn Gly Lys Ile Thr Gly Tyr Ile Ile
980 985 990
Tyr Tyr Ser Thr Asp Val Asn Ala Glu Ile His Asp Trp Val Ile Glu
995 1000 1005
Pro Val Val Gly Asn Arg Leu Thr His Gln Ile Gln Glu Leu Thr
1010 1015 1020
Leu Asp Thr Pro Tyr Tyr Phe Lys Ile Gln Ala Arg Asn Ser Lys
1025 1030 1035
Gly Met Gly Pro Met Ser Glu Ala Val Gln Phe Arg Thr Pro Lys
1040 1045 1050
Ala Asp Ser Ser Asp Lys Met Pro Asn Asp Gln Ala Ser Gly Ser
1055 1060 1065
Gly Gly Lys Gly Ser Arg Leu Pro Asp Leu Gly Ser Asp Tyr Lys
1070 1075 1080
Pro Pro Met Ser Gly Ser Asn Ser Pro His Gly Ser Pro Thr Ser
1085 1090 1095
Pro Leu Asp Ser Asn Met Leu Leu Val Ile Ile Val Ser Val Gly
1100 1105 1110
Val Ile Thr Ile Val Val Val Val Ile Ile Ala Val Phe Cys Thr
1115 1120 1125
Arg Arg Thr Thr Ser His Gln Lys Lys Lys Arg Ala Ala Cys Lys
1130 1135 1140
Ser Val Asn Gly Ser His Lys Tyr Lys Gly Asn Ser Lys Asp Val
1145 1150 1155
Lys Pro Pro Asp Leu Trp Ile His His Glu Arg Leu Glu Leu Lys
1160 1165 1170
Pro Ile Asp Lys Ser Pro Asp Pro Asn Pro Ile Met Thr Asp Thr
1175 1180 1185
Pro Ile Pro Arg Asn Ser Gln Asp Ile Thr Pro Val Asp Asn Ser
1190 1195 1200
Met Asp Ser Asn Ile His Gln Arg Arg Asn Ser Tyr Arg Gly His
1205 1210 1215
Glu Ser Glu Asp Ser Met Ser Thr Leu Ala Gly Arg Arg Gly Met
1220 1225 1230
Arg Pro Lys Met Met Met Pro Phe Asp Ser Gln Pro Pro Gln Pro
1235 1240 1245
Val Ile Ser Ala His Pro Ile His Ser Leu Asp Asn Pro His His
1250 1255 1260
His Phe His Ser Ser Ser Leu Ala Ser Pro Ala Arg Ser His Leu
1265 1270 1275
Tyr His Pro Gly Ser Pro Trp Pro Ile Gly Thr Ser Met Ser Leu
1280 1285 1290
Ser Asp Arg Ala Asn Ser Thr Glu Ser Val Arg Asn Thr Pro Ser
1295 1300 1305
Thr Asp Thr Met Pro Ala Ser Ser Ser Gln Thr Cys Cys Thr Asp
1310 1315 1320
His Gln Asp Pro Glu Gly Ala Thr Ser Ser Ser Tyr Leu Ala Ser
1325 1330 1335
Ser Gln Glu Glu Asp Ser Gly Gln Ser Leu Pro Thr Ala His Val
1340 1345 1350
Arg Pro Ser His Pro Leu Lys Ser Phe Ala Val Pro Ala Ile Pro
1355 1360 1365
Pro Pro Gly Pro Pro Thr Tyr Asp Pro Ala Leu Pro Ser Thr Pro
1370 1375 1380
Leu Leu Ser Gln Gln Ala Leu Asn His His Ile His Ser Val Lys
1385 1390 1395
Thr Ala Ser Ile Gly Thr Leu Gly Arg Ser Arg Pro Pro Met Pro
1400 1405 1410
Val Val Val Pro Ser Ala Pro Glu Val Gln Glu Thr Thr Arg Met
1415 1420 1425
Leu Glu Asp Ser Glu Ser Ser Tyr Glu Pro Asp Glu Leu Thr Lys
1430 1435 1440
Glu Met Ala His Leu Glu Gly Leu Met Lys Asp Leu Asn Ala Ile
1445 1450 1455
Thr Thr Ala
1460
<210> 89
<211> 514
<212> PRT
<213> 智人(Homo sapiens)
<400> 89
Met Ala Asp Ala Glu Val Ile Ile Leu Pro Lys Lys His Lys Lys Lys
1 5 10 15
Lys Glu Arg Lys Ser Leu Pro Glu Glu Asp Val Ala Glu Ile Gln His
20 25 30
Ala Glu Glu Phe Leu Ile Lys Pro Glu Ser Lys Val Ala Lys Leu Asp
35 40 45
Thr Ser Gln Trp Pro Leu Leu Leu Lys Asn Phe Asp Lys Leu Asn Val
50 55 60
Arg Thr Thr His Tyr Thr Pro Leu Ala Cys Gly Ser Asn Pro Leu Lys
65 70 75 80
Arg Glu Ile Gly Asp Tyr Ile Arg Thr Gly Phe Ile Asn Leu Asp Lys
85 90 95
Pro Ser Asn Pro Ser Ser His Glu Val Val Ala Trp Ile Arg Arg Ile
100 105 110
Leu Arg Val Glu Lys Thr Gly His Ser Gly Thr Leu Asp Pro Lys Val
115 120 125
Thr Gly Cys Leu Ile Val Cys Ile Glu Arg Ala Thr Arg Leu Val Lys
130 135 140
Ser Gln Gln Ser Ala Gly Lys Glu Tyr Val Gly Ile Val Arg Leu His
145 150 155 160
Asn Ala Ile Glu Gly Gly Thr Gln Leu Ser Arg Ala Leu Glu Thr Leu
165 170 175
Thr Gly Ala Leu Phe Gln Arg Pro Pro Leu Ile Ala Ala Val Lys Arg
180 185 190
Gln Leu Arg Val Arg Thr Ile Tyr Glu Ser Lys Met Ile Glu Tyr Asp
195 200 205
Pro Glu Arg Arg Leu Gly Ile Phe Trp Val Ser Cys Glu Ala Gly Thr
210 215 220
Tyr Ile Arg Thr Leu Cys Val His Leu Gly Leu Leu Leu Gly Val Gly
225 230 235 240
Gly Gln Met Gln Glu Leu Arg Arg Val Arg Ser Gly Val Met Ser Glu
245 250 255
Lys Asp His Met Val Thr Met His Asp Val Leu Asp Ala Gln Trp Leu
260 265 270
Tyr Asp Asn His Lys Asp Glu Ser Tyr Leu Arg Arg Val Val Tyr Pro
275 280 285
Leu Glu Lys Leu Leu Thr Ser His Lys Arg Leu Val Met Lys Asp Ser
290 295 300
Ala Val Asn Ala Ile Cys Tyr Gly Ala Lys Ile Met Leu Pro Gly Val
305 310 315 320
Leu Arg Tyr Glu Asp Gly Ile Glu Val Asn Gln Glu Ile Val Val Ile
325 330 335
Thr Thr Lys Gly Glu Ala Ile Cys Met Ala Ile Ala Leu Met Thr Thr
340 345 350
Ala Val Ile Ser Thr Cys Asp His Gly Ile Val Ala Lys Ile Lys Arg
355 360 365
Val Ile Met Glu Arg Asp Thr Tyr Pro Arg Lys Trp Gly Leu Gly Pro
370 375 380
Lys Ala Ser Gln Lys Lys Leu Met Ile Lys Gln Gly Leu Leu Asp Lys
385 390 395 400
His Gly Lys Pro Thr Asp Ser Thr Pro Ala Thr Trp Lys Gln Glu Tyr
405 410 415
Val Asp Tyr Ser Glu Ser Ala Lys Lys Glu Val Val Ala Glu Val Val
420 425 430
Lys Ala Pro Gln Val Val Ala Glu Ala Ala Lys Thr Ala Lys Arg Lys
435 440 445
Arg Glu Ser Glu Ser Glu Ser Asp Glu Thr Pro Pro Ala Ala Pro Gln
450 455 460
Leu Ile Lys Lys Glu Lys Lys Lys Ser Lys Lys Asp Lys Lys Ala Lys
465 470 475 480
Ala Gly Leu Glu Ser Gly Ala Glu Pro Gly Asp Gly Asp Ser Asp Thr
485 490 495
Thr Lys Lys Lys Lys Lys Lys Lys Lys Ala Lys Glu Val Glu Leu Val
500 505 510
Ser Glu
<210> 90
<211> 383
<212> PRT
<213> 智人(Homo sapiens)
<400> 90
Met Gly Val Lys Ala Ser Gln Thr Gly Phe Val Val Leu Val Leu Leu
1 5 10 15
Gln Cys Cys Ser Ala Tyr Lys Leu Val Cys Tyr Tyr Thr Ser Trp Ser
20 25 30
Gln Tyr Arg Glu Gly Asp Gly Ser Cys Phe Pro Asp Ala Leu Asp Arg
35 40 45
Phe Leu Cys Thr His Ile Ile Tyr Ser Phe Ala Asn Ile Ser Asn Asp
50 55 60
His Ile Asp Thr Trp Glu Trp Asn Asp Val Thr Leu Tyr Gly Met Leu
65 70 75 80
Asn Thr Leu Lys Asn Arg Asn Pro Asn Leu Lys Thr Leu Leu Ser Val
85 90 95
Gly Gly Trp Asn Phe Gly Ser Gln Arg Phe Ser Lys Ile Ala Ser Asn
100 105 110
Thr Gln Ser Arg Arg Thr Phe Ile Lys Ser Val Pro Pro Phe Leu Arg
115 120 125
Thr His Gly Phe Asp Gly Leu Asp Leu Ala Trp Leu Tyr Pro Gly Arg
130 135 140
Arg Asp Lys Gln His Phe Thr Thr Leu Ile Lys Glu Met Lys Ala Glu
145 150 155 160
Phe Ile Lys Glu Ala Gln Pro Gly Lys Lys Gln Leu Leu Leu Ser Ala
165 170 175
Ala Leu Ser Ala Gly Lys Val Thr Ile Asp Ser Ser Tyr Asp Ile Ala
180 185 190
Lys Ile Ser Gln His Leu Asp Phe Ile Ser Ile Met Thr Tyr Asp Phe
195 200 205
His Gly Ala Trp Arg Gly Thr Thr Gly His His Ser Pro Leu Phe Arg
210 215 220
Gly Gln Glu Asp Ala Ser Pro Asp Arg Phe Ser Asn Thr Asp Tyr Ala
225 230 235 240
Val Gly Tyr Met Leu Arg Leu Gly Ala Pro Ala Ser Lys Leu Val Met
245 250 255
Gly Ile Pro Thr Phe Gly Arg Ser Phe Thr Leu Ala Ser Ser Glu Thr
260 265 270
Gly Val Gly Ala Pro Ile Ser Gly Pro Gly Ile Pro Gly Arg Phe Thr
275 280 285
Lys Glu Ala Gly Thr Leu Ala Tyr Tyr Glu Ile Cys Asp Phe Leu Arg
290 295 300
Gly Ala Thr Val His Arg Ile Leu Gly Gln Gln Val Pro Tyr Ala Thr
305 310 315 320
Lys Gly Asn Gln Trp Val Gly Tyr Asp Asp Gln Glu Ser Val Lys Ser
325 330 335
Lys Val Gln Tyr Leu Lys Asp Arg Gln Leu Ala Gly Ala Met Val Trp
340 345 350
Ala Leu Asp Leu Asp Asp Phe Gln Gly Ser Phe Cys Gly Gln Asp Leu
355 360 365
Arg Phe Pro Leu Thr Asn Ala Ile Lys Asp Ala Leu Ala Ala Thr
370 375 380
<210> 91
<211> 965
<212> PRT
<213> 智人(Homo sapiens)
<400> 91
Met Ala Leu Leu Cys Gly Leu Gly Gln Val Thr Leu Arg Ile Trp Val
1 5 10 15
Ser Leu Pro Ser Gln Ser Glu Asn Gly Ile Gly Phe Leu Ala Ala Arg
20 25 30
Ala Phe Leu Arg Ser Gly Gly Met Glu Ala Leu Thr Thr Gln Leu Gly
35 40 45
Pro Gly Arg Glu Gly Ser Ser Ser Pro Asn Ser Lys Gln Glu Leu Gln
50 55 60
Pro Tyr Ser Gly Ser Ser Ala Leu Lys Pro Asn Gln Val Gly Glu Thr
65 70 75 80
Ser Leu Tyr Gly Val Pro Ile Val Ser Leu Val Ile Asp Gly Gln Glu
85 90 95
Arg Leu Cys Leu Ala Gln Ile Ser Asn Thr Leu Leu Lys Asn Tyr Ser
100 105 110
Tyr Asn Glu Ile His Asn Arg Arg Val Ala Leu Gly Ile Thr Cys Val
115 120 125
Gln Cys Thr Pro Val Gln Leu Glu Ile Leu Arg Arg Ala Gly Ala Met
130 135 140
Pro Ile Ser Ser Arg Arg Cys Gly Met Ile Thr Lys Arg Glu Ala Glu
145 150 155 160
Arg Leu Cys Lys Ser Phe Leu Gly Glu His Lys Pro Pro Lys Leu Pro
165 170 175
Glu Asn Phe Ala Phe Asp Val Val His Glu Cys Ala Trp Gly Ser Arg
180 185 190
Gly Ser Phe Ile Pro Ala Arg Tyr Asn Ser Ser Arg Ala Lys Cys Ile
195 200 205
Lys Cys Gly Tyr Cys Ser Met Tyr Phe Ser Pro Asn Lys Phe Ile Phe
210 215 220
His Ser His Arg Thr Pro Asp Ala Lys Tyr Thr Gln Pro Asp Ala Ala
225 230 235 240
Asn Phe Asn Ser Trp Arg Arg His Leu Lys Leu Ser Asp Lys Ser Ala
245 250 255
Thr Asp Glu Leu Ser His Ala Trp Glu Asp Val Lys Ala Met Phe Asn
260 265 270
Gly Gly Thr Arg Lys Arg Thr Phe Ser Leu Gln Gly Gly Gly Gly Gly
275 280 285
Gly Ala Asn Gly Gly Ser Gly Gly Gln Gly Lys Gly Gly Ala Gly Gly
290 295 300
Gly Gly Gly Gly Gly Pro Gly Cys Gly Ala Glu Met Ala Pro Gly Pro
305 310 315 320
Pro Pro His Lys Ser Leu Arg Cys Gly Glu Asp Glu Ala Ala Gly Pro
325 330 335
Pro Gly Pro Pro Pro Pro His Pro Gln Arg Gly Leu Gly Leu Ala Thr
340 345 350
Gly Ala Ser Gly Pro Ala Gly Pro Gly Gly Pro Gly Gly Gly Ala Gly
355 360 365
Val Arg Ser Tyr Pro Val Ile Pro Val Pro Ser Lys Gly Phe Gly Leu
370 375 380
Leu Gln Lys Leu Pro Pro Pro Leu Phe Pro His Pro Tyr Gly Phe Pro
385 390 395 400
Thr Ala Phe Gly Leu Cys Pro Lys Lys Asp Asp Pro Val Leu Gly Ala
405 410 415
Gly Glu Pro Lys Gly Gly Pro Gly Thr Gly Ser Gly Gly Gly Gly Ala
420 425 430
Gly Thr Gly Gly Gly Ala Gly Gly Pro Gly Ala Ser His Leu Pro Pro
435 440 445
Gly Ala Gly Ala Gly Pro Gly Gly Gly Ala Met Phe Trp Gly His Gln
450 455 460
Pro Ser Gly Ala Ala Lys Asp Ala Ala Ala Val Ala Ala Ala Ala Ala
465 470 475 480
Ala Ala Thr Val Tyr Pro Thr Phe Pro Met Phe Trp Pro Ala Ala Gly
485 490 495
Ser Leu Pro Val Pro Ser Tyr Pro Ala Ala Gln Ser Gln Ala Lys Ala
500 505 510
Val Ala Ala Ala Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala
515 520 525
Gly Ser Gly Ala Pro Glu Pro Leu Asp Gly Ala Glu Pro Ala Lys Glu
530 535 540
Ser Gly Leu Gly Ala Glu Glu Arg Cys Pro Ser Ala Leu Ser Arg Gly
545 550 555 560
Pro Leu Asp Glu Asp Gly Thr Asp Glu Ala Leu Pro Pro Pro Leu Ala
565 570 575
Pro Leu Pro Pro Pro Pro Pro Pro Pro Ala Arg Lys Gly Ser Tyr Val
580 585 590
Ser Ala Phe Arg Pro Val Val Lys Asp Thr Glu Ser Ile Ala Lys Leu
595 600 605
Tyr Gly Ser Ala Arg Glu Ala Tyr Gly Ala Gly Pro Ala Arg Gly Pro
610 615 620
Gly Pro Gly Ala Gly Ser Gly Gly Tyr Val Ser Pro Asp Phe Leu Ser
625 630 635 640
Glu Gly Ser Ser Ser Tyr Asn Ser Ala Ser Pro Asp Val Asp Thr Ala
645 650 655
Asp Glu Pro Glu Val Asp Val Glu Ser Asn Arg Phe Pro Asp Asp Glu
660 665 670
Asp Ala Gln Glu Glu Thr Glu Pro Ser Ala Pro Ser Ala Gly Gly Gly
675 680 685
Pro Asp Gly Glu Gln Pro Thr Gly Pro Pro Ser Ala Thr Ser Ser Gly
690 695 700
Ala Asp Gly Pro Ala Asn Ser Pro Asp Gly Gly Ser Pro Arg Pro Arg
705 710 715 720
Arg Arg Leu Gly Pro Pro Pro Ala Gly Arg Pro Ala Phe Gly Asp Leu
725 730 735
Ala Ala Glu Asp Leu Val Arg Arg Pro Glu Arg Ser Pro Pro Ser Gly
740 745 750
Gly Gly Gly Tyr Glu Leu Arg Glu Pro Cys Gly Pro Leu Gly Gly Pro
755 760 765
Ala Pro Ala Lys Val Phe Ala Pro Glu Arg Asp Glu His Val Lys Ser
770 775 780
Ala Ala Val Ala Leu Gly Pro Ala Ala Ser Tyr Val Cys Thr Pro Glu
785 790 795 800
Ala His Glu Pro Asp Lys Glu Asp Asn His Ser Pro Ala Asp Asp Leu
805 810 815
Glu Thr Arg Lys Ser Tyr Pro Asp Gln Arg Ser Ile Ser Gln Pro Ser
820 825 830
Pro Ala Asn Thr Asp Arg Gly Glu Asp Gly Leu Thr Leu Asp Val Thr
835 840 845
Gly Thr His Leu Val Glu Lys Asp Ile Glu Asn Leu Ala Arg Glu Glu
850 855 860
Leu Gln Lys Leu Leu Leu Glu Gln Met Glu Leu Arg Lys Lys Leu Glu
865 870 875 880
Arg Glu Phe Gln Ser Leu Lys Asp Asn Phe Gln Asp Gln Met Lys Arg
885 890 895
Glu Leu Ala Tyr Arg Glu Glu Met Val Gln Gln Leu Gln Ile Val Arg
900 905 910
Asp Thr Leu Cys Asn Glu Leu Asp Gln Glu Arg Lys Ala Arg Tyr Ala
915 920 925
Ile Gln Gln Lys Leu Lys Glu Ala His Asp Ala Leu His His Phe Ser
930 935 940
Cys Lys Met Leu Thr Pro Arg His Cys Thr Gly Asn Cys Ser Phe Lys
945 950 955 960
Pro Pro Leu Leu Pro
965
<210> 92
<211> 709
<212> PRT
<213> 智人(Homo sapiens)
<400> 92
Met Ala Glu Thr Leu Glu Phe Asn Asp Val Tyr Gln Glu Val Lys Gly
1 5 10 15
Ser Met Asn Asp Gly Arg Leu Arg Leu Ser Arg Gln Gly Ile Ile Phe
20 25 30
Lys Asn Ser Lys Thr Gly Lys Val Asp Asn Ile Gln Ala Gly Glu Leu
35 40 45
Thr Glu Gly Ile Trp Arg Arg Val Ala Leu Gly His Gly Leu Lys Leu
50 55 60
Leu Thr Lys Asn Gly His Val Tyr Lys Tyr Asp Gly Phe Arg Glu Ser
65 70 75 80
Glu Phe Glu Lys Leu Ser Asp Phe Phe Lys Thr His Tyr Arg Leu Glu
85 90 95
Leu Met Glu Lys Asp Leu Cys Val Lys Gly Trp Asn Trp Gly Thr Val
100 105 110
Lys Phe Gly Gly Gln Leu Leu Ser Phe Asp Ile Gly Asp Gln Pro Val
115 120 125
Phe Glu Ile Pro Leu Ser Asn Val Ser Gln Cys Thr Thr Gly Lys Asn
130 135 140
Glu Val Thr Leu Glu Phe His Gln Asn Asp Asp Ala Glu Val Ser Leu
145 150 155 160
Met Glu Val Arg Phe Tyr Val Pro Pro Thr Gln Glu Asp Gly Val Asp
165 170 175
Pro Val Glu Ala Phe Ala Gln Asn Val Leu Ser Lys Ala Asp Val Ile
180 185 190
Gln Ala Thr Gly Asp Ala Ile Cys Ile Phe Arg Glu Leu Gln Cys Leu
195 200 205
Thr Pro Arg Gly Arg Tyr Asp Ile Arg Ile Tyr Pro Thr Phe Leu His
210 215 220
Leu His Gly Lys Thr Phe Asp Tyr Lys Ile Pro Tyr Thr Thr Val Leu
225 230 235 240
Arg Leu Phe Leu Leu Pro His Lys Asp Gln Arg Gln Met Phe Phe Val
245 250 255
Ile Ser Leu Asp Pro Pro Ile Lys Gln Gly Gln Thr Arg Tyr His Phe
260 265 270
Leu Ile Leu Leu Phe Ser Lys Asp Glu Asp Ile Ser Leu Thr Leu Asn
275 280 285
Met Asn Glu Glu Glu Val Glu Lys Arg Phe Glu Gly Arg Leu Thr Lys
290 295 300
Asn Met Ser Gly Ser Leu Tyr Glu Met Val Ser Arg Val Met Lys Ala
305 310 315 320
Leu Val Asn Arg Lys Ile Thr Val Pro Gly Asn Phe Gln Gly His Ser
325 330 335
Gly Ala Gln Cys Ile Thr Cys Ser Tyr Lys Ala Ser Ser Gly Leu Leu
340 345 350
Tyr Pro Leu Glu Arg Gly Phe Ile Tyr Val His Lys Pro Pro Val His
355 360 365
Ile Arg Phe Asp Glu Ile Ser Phe Val Asn Phe Ala Arg Gly Thr Thr
370 375 380
Thr Thr Arg Ser Phe Asp Phe Glu Ile Glu Thr Lys Gln Gly Thr Gln
385 390 395 400
Tyr Thr Phe Ser Ser Ile Glu Arg Glu Glu Tyr Gly Lys Leu Phe Asp
405 410 415
Phe Val Asn Ala Lys Lys Leu Asn Ile Lys Asn Arg Gly Leu Lys Glu
420 425 430
Gly Met Asn Pro Ser Tyr Asp Glu Tyr Ala Asp Ser Asp Glu Asp Gln
435 440 445
His Asp Ala Tyr Leu Glu Arg Met Lys Glu Glu Gly Lys Ile Arg Glu
450 455 460
Glu Asn Ala Asn Asp Ser Ser Asp Asp Ser Gly Glu Glu Thr Asp Glu
465 470 475 480
Ser Phe Asn Pro Gly Glu Glu Glu Glu Asp Val Ala Glu Glu Phe Asp
485 490 495
Ser Asn Ala Ser Ala Ser Ser Ser Ser Asn Glu Gly Asp Ser Asp Arg
500 505 510
Asp Glu Lys Lys Arg Lys Gln Leu Lys Lys Ala Lys Met Ala Lys Asp
515 520 525
Arg Lys Ser Arg Lys Lys Pro Val Glu Val Lys Lys Gly Lys Asp Pro
530 535 540
Asn Ala Pro Lys Arg Pro Met Ser Ala Tyr Met Leu Trp Leu Asn Ala
545 550 555 560
Ser Arg Glu Lys Ile Lys Ser Asp His Pro Gly Ile Ser Ile Thr Asp
565 570 575
Leu Ser Lys Lys Ala Gly Glu Ile Trp Lys Gly Met Ser Lys Glu Lys
580 585 590
Lys Glu Glu Trp Asp Arg Lys Ala Glu Asp Ala Arg Arg Asp Tyr Glu
595 600 605
Lys Ala Met Lys Glu Tyr Glu Gly Gly Arg Gly Glu Ser Ser Lys Arg
610 615 620
Asp Lys Ser Lys Lys Lys Lys Lys Val Lys Val Lys Met Glu Lys Lys
625 630 635 640
Ser Thr Pro Ser Arg Gly Ser Ser Ser Lys Ser Ser Ser Arg Gln Leu
645 650 655
Ser Glu Ser Phe Lys Ser Lys Glu Phe Val Ser Ser Asp Glu Ser Ser
660 665 670
Ser Gly Glu Asn Lys Ser Lys Lys Lys Arg Arg Arg Ser Glu Asp Ser
675 680 685
Glu Glu Glu Glu Leu Ala Ser Thr Pro Pro Ser Ser Glu Asp Ser Ala
690 695 700
Ser Gly Ser Asp Glu
705
<210> 93
<211> 1712
<212> PRT
<213> 智人(Homo sapiens)
<400> 93
Met Gly Arg Asp Gln Arg Ala Val Ala Gly Pro Ala Leu Arg Arg Trp
1 5 10 15
Leu Leu Leu Gly Thr Val Thr Val Gly Phe Leu Ala Gln Ser Val Leu
20 25 30
Ala Gly Val Lys Lys Phe Asp Val Pro Cys Gly Gly Arg Asp Cys Ser
35 40 45
Gly Gly Cys Gln Cys Tyr Pro Glu Lys Gly Gly Arg Gly Gln Pro Gly
50 55 60
Pro Val Gly Pro Gln Gly Tyr Asn Gly Pro Pro Gly Leu Gln Gly Phe
65 70 75 80
Pro Gly Leu Gln Gly Arg Lys Gly Asp Lys Gly Glu Arg Gly Ala Pro
85 90 95
Gly Val Thr Gly Pro Lys Gly Asp Val Gly Ala Arg Gly Val Ser Gly
100 105 110
Phe Pro Gly Ala Asp Gly Ile Pro Gly His Pro Gly Gln Gly Gly Pro
115 120 125
Arg Gly Arg Pro Gly Tyr Asp Gly Cys Asn Gly Thr Gln Gly Asp Ser
130 135 140
Gly Pro Gln Gly Pro Pro Gly Ser Glu Gly Phe Thr Gly Pro Pro Gly
145 150 155 160
Pro Gln Gly Pro Lys Gly Gln Lys Gly Glu Pro Tyr Ala Leu Pro Lys
165 170 175
Glu Glu Arg Asp Arg Tyr Arg Gly Glu Pro Gly Glu Pro Gly Leu Val
180 185 190
Gly Phe Gln Gly Pro Pro Gly Arg Pro Gly His Val Gly Gln Met Gly
195 200 205
Pro Val Gly Ala Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro
210 215 220
Lys Gly Gln Gln Gly Asn Arg Gly Leu Gly Phe Tyr Gly Val Lys Gly
225 230 235 240
Glu Lys Gly Asp Val Gly Gln Pro Gly Pro Asn Gly Ile Pro Ser Asp
245 250 255
Thr Leu His Pro Ile Ile Ala Pro Thr Gly Val Thr Phe His Pro Asp
260 265 270
Gln Tyr Lys Gly Glu Lys Gly Ser Glu Gly Glu Pro Gly Ile Arg Gly
275 280 285
Ile Ser Leu Lys Gly Glu Glu Gly Ile Met Gly Phe Pro Gly Leu Arg
290 295 300
Gly Tyr Pro Gly Leu Ser Gly Glu Lys Gly Ser Pro Gly Gln Lys Gly
305 310 315 320
Ser Arg Gly Leu Asp Gly Tyr Gln Gly Pro Asp Gly Pro Arg Gly Pro
325 330 335
Lys Gly Glu Ala Gly Asp Pro Gly Pro Pro Gly Leu Pro Ala Tyr Ser
340 345 350
Pro His Pro Ser Leu Ala Lys Gly Ala Arg Gly Asp Pro Gly Phe Pro
355 360 365
Gly Ala Gln Gly Glu Pro Gly Ser Gln Gly Glu Pro Gly Asp Pro Gly
370 375 380
Leu Pro Gly Pro Pro Gly Leu Ser Ile Gly Asp Gly Asp Gln Arg Arg
385 390 395 400
Gly Leu Pro Gly Glu Met Gly Pro Lys Gly Phe Ile Gly Asp Pro Gly
405 410 415
Ile Pro Ala Leu Tyr Gly Gly Pro Pro Gly Pro Asp Gly Lys Arg Gly
420 425 430
Pro Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Asp Gly Phe
435 440 445
Leu Phe Gly Leu Lys Gly Ala Lys Gly Arg Ala Gly Phe Pro Gly Leu
450 455 460
Pro Gly Ser Pro Gly Ala Arg Gly Pro Lys Gly Trp Lys Gly Asp Ala
465 470 475 480
Gly Glu Cys Arg Cys Thr Glu Gly Asp Glu Ala Ile Lys Gly Leu Pro
485 490 495
Gly Leu Pro Gly Pro Lys Gly Phe Ala Gly Ile Asn Gly Glu Pro Gly
500 505 510
Arg Lys Gly Asp Arg Gly Asp Pro Gly Gln His Gly Leu Pro Gly Phe
515 520 525
Pro Gly Leu Lys Gly Val Pro Gly Asn Ile Gly Ala Pro Gly Pro Lys
530 535 540
Gly Ala Lys Gly Asp Ser Arg Thr Ile Thr Thr Lys Gly Glu Arg Gly
545 550 555 560
Gln Pro Gly Val Pro Gly Val Pro Gly Met Lys Gly Asp Asp Gly Ser
565 570 575
Pro Gly Arg Asp Gly Leu Asp Gly Phe Pro Gly Leu Pro Gly Pro Pro
580 585 590
Gly Asp Gly Ile Lys Gly Pro Pro Gly Asp Pro Gly Tyr Pro Gly Ile
595 600 605
Pro Gly Thr Lys Gly Thr Pro Gly Glu Met Gly Pro Pro Gly Leu Gly
610 615 620
Leu Pro Gly Leu Lys Gly Gln Arg Gly Phe Pro Gly Asp Ala Gly Leu
625 630 635 640
Pro Gly Pro Pro Gly Phe Leu Gly Pro Pro Gly Pro Ala Gly Thr Pro
645 650 655
Gly Gln Ile Asp Cys Asp Thr Asp Val Lys Arg Ala Val Gly Gly Asp
660 665 670
Arg Gln Glu Ala Ile Gln Pro Gly Cys Ile Gly Gly Pro Lys Gly Leu
675 680 685
Pro Gly Leu Pro Gly Pro Pro Gly Pro Thr Gly Ala Lys Gly Leu Arg
690 695 700
Gly Ile Pro Gly Phe Ala Gly Ala Asp Gly Gly Pro Gly Pro Arg Gly
705 710 715 720
Leu Pro Gly Asp Ala Gly Arg Glu Gly Phe Pro Gly Pro Pro Gly Phe
725 730 735
Ile Gly Pro Arg Gly Ser Lys Gly Ala Val Gly Leu Pro Gly Pro Asp
740 745 750
Gly Ser Pro Gly Pro Ile Gly Leu Pro Gly Pro Asp Gly Pro Pro Gly
755 760 765
Glu Arg Gly Leu Pro Gly Glu Val Leu Gly Ala Gln Pro Gly Pro Arg
770 775 780
Gly Asp Ala Gly Val Pro Gly Gln Pro Gly Leu Lys Gly Leu Pro Gly
785 790 795 800
Asp Arg Gly Pro Pro Gly Phe Arg Gly Ser Gln Gly Met Pro Gly Met
805 810 815
Pro Gly Leu Lys Gly Gln Pro Gly Leu Pro Gly Pro Ser Gly Gln Pro
820 825 830
Gly Leu Tyr Gly Pro Pro Gly Leu His Gly Phe Pro Gly Ala Pro Gly
835 840 845
Gln Glu Gly Pro Leu Gly Leu Pro Gly Ile Pro Gly Arg Glu Gly Leu
850 855 860
Pro Gly Asp Arg Gly Asp Pro Gly Asp Thr Gly Ala Pro Gly Pro Val
865 870 875 880
Gly Met Lys Gly Leu Ser Gly Asp Arg Gly Asp Ala Gly Phe Thr Gly
885 890 895
Glu Gln Gly His Pro Gly Ser Pro Gly Phe Lys Gly Ile Asp Gly Met
900 905 910
Pro Gly Thr Pro Gly Leu Lys Gly Asp Arg Gly Ser Pro Gly Met Asp
915 920 925
Gly Phe Gln Gly Met Pro Gly Leu Lys Gly Arg Pro Gly Phe Pro Gly
930 935 940
Ser Lys Gly Glu Ala Gly Phe Phe Gly Ile Pro Gly Leu Lys Gly Leu
945 950 955 960
Ala Gly Glu Pro Gly Phe Lys Gly Ser Arg Gly Asp Pro Gly Pro Pro
965 970 975
Gly Pro Pro Pro Val Ile Leu Pro Gly Met Lys Asp Ile Lys Gly Glu
980 985 990
Lys Gly Asp Glu Gly Pro Met Gly Leu Lys Gly Tyr Leu Gly Ala Lys
995 1000 1005
Gly Ile Gln Gly Met Pro Gly Ile Pro Gly Leu Ser Gly Ile Pro
1010 1015 1020
Gly Leu Pro Gly Arg Pro Gly His Ile Lys Gly Val Lys Gly Asp
1025 1030 1035
Ile Gly Val Pro Gly Ile Pro Gly Leu Pro Gly Phe Pro Gly Val
1040 1045 1050
Ala Gly Pro Pro Gly Ile Thr Gly Phe Pro Gly Phe Ile Gly Ser
1055 1060 1065
Arg Gly Asp Lys Gly Ala Pro Gly Arg Ala Gly Leu Tyr Gly Glu
1070 1075 1080
Ile Gly Ala Thr Gly Asp Phe Gly Asp Ile Gly Asp Thr Ile Asn
1085 1090 1095
Leu Pro Gly Arg Pro Gly Leu Lys Gly Glu Arg Gly Thr Thr Gly
1100 1105 1110
Ile Pro Gly Leu Lys Gly Phe Phe Gly Glu Lys Gly Thr Glu Gly
1115 1120 1125
Asp Ile Gly Phe Pro Gly Ile Thr Gly Val Thr Gly Val Gln Gly
1130 1135 1140
Pro Pro Gly Leu Lys Gly Gln Thr Gly Phe Pro Gly Leu Thr Gly
1145 1150 1155
Pro Pro Gly Ser Gln Gly Glu Leu Gly Arg Ile Gly Leu Pro Gly
1160 1165 1170
Gly Lys Gly Asp Asp Gly Trp Pro Gly Ala Pro Gly Leu Pro Gly
1175 1180 1185
Phe Pro Gly Leu Arg Gly Ile Arg Gly Leu His Gly Leu Pro Gly
1190 1195 1200
Thr Lys Gly Phe Pro Gly Ser Pro Gly Ser Asp Ile His Gly Asp
1205 1210 1215
Pro Gly Phe Pro Gly Pro Pro Gly Glu Arg Gly Asp Pro Gly Glu
1220 1225 1230
Ala Asn Thr Leu Pro Gly Pro Val Gly Val Pro Gly Gln Lys Gly
1235 1240 1245
Asp Gln Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Ser Pro Gly
1250 1255 1260
Leu Gln Gly Phe Pro Gly Ile Thr Pro Pro Ser Asn Ile Ser Gly
1265 1270 1275
Ala Pro Gly Asp Lys Gly Ala Pro Gly Ile Phe Gly Leu Lys Gly
1280 1285 1290
Tyr Arg Gly Pro Pro Gly Pro Pro Gly Ser Ala Ala Leu Pro Gly
1295 1300 1305
Ser Lys Gly Asp Thr Gly Asn Pro Gly Ala Pro Gly Thr Pro Gly
1310 1315 1320
Thr Lys Gly Trp Ala Gly Asp Ser Gly Pro Gln Gly Arg Pro Gly
1325 1330 1335
Val Phe Gly Leu Pro Gly Glu Lys Gly Pro Arg Gly Glu Gln Gly
1340 1345 1350
Phe Met Gly Asn Thr Gly Pro Thr Gly Ala Val Gly Asp Arg Gly
1355 1360 1365
Pro Lys Gly Pro Lys Gly Asp Pro Gly Phe Pro Gly Ala Pro Gly
1370 1375 1380
Thr Val Gly Ala Pro Gly Ile Ala Gly Ile Pro Gln Lys Ile Ala
1385 1390 1395
Val Gln Pro Gly Thr Val Gly Pro Gln Gly Arg Arg Gly Pro Pro
1400 1405 1410
Gly Ala Pro Gly Glu Met Gly Pro Gln Gly Pro Pro Gly Glu Pro
1415 1420 1425
Gly Phe Arg Gly Ala Pro Gly Lys Ala Gly Pro Gln Gly Arg Gly
1430 1435 1440
Gly Val Ser Ala Val Pro Gly Phe Arg Gly Asp Glu Gly Pro Ile
1445 1450 1455
Gly His Gln Gly Pro Ile Gly Gln Glu Gly Ala Pro Gly Arg Pro
1460 1465 1470
Gly Ser Pro Gly Leu Pro Gly Met Pro Gly Arg Ser Val Ser Ile
1475 1480 1485
Gly Tyr Leu Leu Val Lys His Ser Gln Thr Asp Gln Glu Pro Met
1490 1495 1500
Cys Pro Val Gly Met Asn Lys Leu Trp Ser Gly Tyr Ser Leu Leu
1505 1510 1515
Tyr Phe Glu Gly Gln Glu Lys Ala His Asn Gln Asp Leu Gly Leu
1520 1525 1530
Ala Gly Ser Cys Leu Ala Arg Phe Ser Thr Met Pro Phe Leu Tyr
1535 1540 1545
Cys Asn Pro Gly Asp Val Cys Tyr Tyr Ala Ser Arg Asn Asp Lys
1550 1555 1560
Ser Tyr Trp Leu Ser Thr Thr Ala Pro Leu Pro Met Met Pro Val
1565 1570 1575
Ala Glu Asp Glu Ile Lys Pro Tyr Ile Ser Arg Cys Ser Val Cys
1580 1585 1590
Glu Ala Pro Ala Ile Ala Ile Ala Val His Ser Gln Asp Val Ser
1595 1600 1605
Ile Pro His Cys Pro Ala Gly Trp Arg Ser Leu Trp Ile Gly Tyr
1610 1615 1620
Ser Phe Leu Met His Thr Ala Ala Gly Asp Glu Gly Gly Gly Gln
1625 1630 1635
Ser Leu Val Ser Pro Gly Ser Cys Leu Glu Asp Phe Arg Ala Thr
1640 1645 1650
Pro Phe Ile Glu Cys Asn Gly Gly Arg Gly Thr Cys His Tyr Tyr
1655 1660 1665
Ala Asn Lys Tyr Ser Phe Trp Leu Thr Thr Ile Pro Glu Gln Ser
1670 1675 1680
Phe Gln Gly Ser Pro Ser Ala Asp Thr Leu Lys Ala Gly Leu Ile
1685 1690 1695
Arg Thr His Ile Ser Arg Cys Gln Val Cys Met Lys Asn Leu
1700 1705 1710
<210> 94
<211> 152
<212> PRT
<213> 智人(Homo sapiens)
<400> 94
Met Ala Asn Cys Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val
1 5 10 15
Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly
20 25 30
Phe Arg Leu Val Gly Leu Lys Phe Met Gln Ala Ser Glu Asp Leu Leu
35 40 45
Lys Glu His Tyr Val Asp Leu Lys Asp Arg Pro Phe Phe Ala Gly Leu
50 55 60
Val Lys Tyr Met His Ser Gly Pro Val Val Ala Met Val Trp Glu Gly
65 70 75 80
Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro
85 90 95
Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val
100 105 110
Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Glu Ser Ala Glu Lys
115 120 125
Glu Ile Gly Leu Trp Phe His Pro Glu Glu Leu Val Asp Tyr Thr Ser
130 135 140
Cys Ala Gln Asn Trp Ile Tyr Glu
145 150
<210> 95
<211> 764
<212> PRT
<213> 智人(Homo sapiens)
<400> 95
Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu
1 5 10 15
Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg
20 25 30
Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser
35 40 45
Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser
50 55 60
Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly
65 70 75 80
Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala
85 90 95
Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly
100 105 110
Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser
115 120 125
Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr
130 135 140
Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn
145 150 155 160
Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys
165 170 175
Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser
180 185 190
Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly
195 200 205
Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr
210 215 220
Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu
225 230 235 240
Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln
245 250 255
Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr
260 265 270
Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly
275 280 285
Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly
290 295 300
Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile
305 310 315 320
Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr
325 330 335
Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly
340 345 350
Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp
355 360 365
Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile
370 375 380
Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr
385 390 395 400
Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys
405 410 415
Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro
420 425 430
Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn
435 440 445
Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val
450 455 460
Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met
465 470 475 480
Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln
485 490 495
Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met
500 505 510
Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe
515 520 525
Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu
530 535 540
Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn
545 550 555 560
Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp
565 570 575
Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile
580 585 590
Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg
595 600 605
Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro
610 615 620
Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu
625 630 635 640
Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys
645 650 655
Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile
660 665 670
Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro
675 680 685
Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile
690 695 700
Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly
705 710 715 720
Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala
725 730 735
His Ala Arg Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu
740 745 750
Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu
755 760
<210> 96
<211> 472
<212> PRT
<213> 智人(Homo sapiens)
<400> 96
Met Ala Gly Gly Glu Ala Gly Val Thr Leu Gly Gln Pro His Leu Ser
1 5 10 15
Arg Gln Asp Leu Thr Thr Leu Asp Val Thr Lys Leu Thr Pro Leu Ser
20 25 30
His Glu Val Ile Ser Arg Gln Ala Thr Ile Asn Ile Gly Thr Ile Gly
35 40 45
His Val Ala His Gly Lys Ser Thr Val Val Lys Ala Ile Ser Gly Val
50 55 60
His Thr Val Arg Phe Lys Asn Glu Leu Glu Arg Asn Ile Thr Ile Lys
65 70 75 80
Leu Gly Tyr Ala Asn Ala Lys Ile Tyr Lys Leu Asp Asp Pro Ser Cys
85 90 95
Pro Arg Pro Glu Cys Tyr Arg Ser Cys Gly Ser Ser Thr Pro Asp Glu
100 105 110
Phe Pro Thr Asp Ile Pro Gly Thr Lys Gly Asn Phe Lys Leu Val Arg
115 120 125
His Val Ser Phe Val Asp Cys Pro Gly His Asp Ile Leu Met Ala Thr
130 135 140
Met Leu Asn Gly Ala Ala Val Met Asp Ala Ala Leu Leu Leu Ile Ala
145 150 155 160
Gly Asn Glu Ser Cys Pro Gln Pro Gln Thr Ser Glu His Leu Ala Ala
165 170 175
Ile Glu Ile Met Lys Leu Lys His Ile Leu Ile Leu Gln Asn Lys Ile
180 185 190
Asp Leu Val Lys Glu Ser Gln Ala Lys Glu Gln Tyr Glu Gln Ile Leu
195 200 205
Ala Phe Val Gln Gly Thr Val Ala Glu Gly Ala Pro Ile Ile Pro Ile
210 215 220
Ser Ala Gln Leu Lys Tyr Asn Ile Glu Val Val Cys Glu Tyr Ile Val
225 230 235 240
Lys Lys Ile Pro Val Pro Pro Arg Asp Phe Thr Ser Glu Pro Arg Leu
245 250 255
Ile Val Ile Arg Ser Phe Asp Val Asn Lys Pro Gly Cys Glu Val Asp
260 265 270
Asp Leu Lys Gly Gly Val Ala Gly Gly Ser Ile Leu Lys Gly Val Leu
275 280 285
Lys Val Gly Gln Glu Ile Glu Val Arg Pro Gly Ile Val Ser Lys Asp
290 295 300
Ser Glu Gly Lys Leu Met Cys Lys Pro Ile Phe Ser Lys Ile Val Ser
305 310 315 320
Leu Phe Ala Glu His Asn Asp Leu Gln Tyr Ala Ala Pro Gly Gly Leu
325 330 335
Ile Gly Val Gly Thr Lys Ile Asp Pro Thr Leu Cys Arg Ala Asp Arg
340 345 350
Met Val Gly Gln Val Leu Gly Ala Val Gly Ala Leu Pro Glu Ile Phe
355 360 365
Thr Glu Leu Glu Ile Ser Tyr Phe Leu Leu Arg Arg Leu Leu Gly Val
370 375 380
Arg Thr Glu Gly Asp Lys Lys Ala Ala Lys Val Gln Lys Leu Ser Lys
385 390 395 400
Asn Glu Val Leu Met Val Asn Ile Gly Ser Leu Ser Thr Gly Gly Arg
405 410 415
Val Ser Ala Val Lys Ala Asp Leu Gly Lys Ile Val Leu Thr Asn Pro
420 425 430
Val Cys Thr Glu Val Gly Glu Lys Ile Ala Leu Ser Arg Arg Val Glu
435 440 445
Lys His Trp Arg Leu Ile Gly Trp Gly Gln Ile Arg Arg Gly Val Thr
450 455 460
Ile Lys Pro Thr Val Asp Asp Asp
465 470
<210> 97
<211> 572
<212> PRT
<213> 智人(Homo sapiens)
<400> 97
Met Ser Tyr Gln Gly Lys Lys Asn Ile Pro Arg Ile Thr Ser Asp Arg
1 5 10 15
Leu Leu Ile Lys Gly Gly Lys Ile Val Asn Asp Asp Gln Ser Phe Tyr
20 25 30
Ala Asp Ile Tyr Met Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn
35 40 45
Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala His Ser Arg Met
50 55 60
Val Ile Pro Gly Gly Ile Asp Val His Thr Arg Phe Gln Met Pro Asp
65 70 75 80
Gln Gly Met Thr Ser Ala Asp Asp Phe Phe Gln Gly Thr Lys Ala Ala
85 90 95
Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro
100 105 110
Gly Thr Ser Leu Leu Ala Ala Phe Asp Gln Trp Arg Glu Trp Ala Asp
115 120 125
Ser Lys Ser Cys Cys Asp Tyr Ser Leu His Val Asp Ile Ser Glu Trp
130 135 140
His Lys Gly Ile Gln Glu Glu Met Glu Ala Leu Val Lys Asp His Gly
145 150 155 160
Val Asn Ser Phe Leu Val Tyr Met Ala Phe Lys Asp Arg Phe Gln Leu
165 170 175
Thr Asp Cys Gln Ile Tyr Glu Val Leu Ser Val Ile Arg Asp Ile Gly
180 185 190
Ala Ile Ala Gln Val His Ala Glu Asn Gly Asp Ile Ile Ala Glu Glu
195 200 205
Gln Gln Arg Ile Leu Asp Leu Gly Ile Thr Gly Pro Glu Gly His Val
210 215 220
Leu Ser Arg Pro Glu Glu Val Glu Ala Glu Ala Val Asn Arg Ala Ile
225 230 235 240
Thr Ile Ala Asn Gln Thr Asn Cys Pro Leu Tyr Ile Thr Lys Val Met
245 250 255
Ser Lys Ser Ser Ala Glu Val Ile Ala Gln Ala Arg Lys Lys Gly Thr
260 265 270
Val Val Tyr Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly Ser
275 280 285
His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser
290 295 300
Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Phe Leu Asn Ser Leu
305 310 315 320
Leu Ser Cys Gly Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr Phe
325 330 335
Asn Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile Pro
340 345 350
Glu Gly Thr Asn Gly Thr Glu Glu Arg Met Ser Val Ile Trp Asp Lys
355 360 365
Ala Val Val Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr
370 375 380
Ser Thr Asn Ala Ala Lys Val Phe Asn Leu Tyr Pro Arg Lys Gly Arg
385 390 395 400
Ile Ala Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asp Pro Asp Ser
405 410 415
Val Lys Thr Ile Ser Ala Lys Thr His Asn Ser Ser Leu Glu Tyr Asn
420 425 430
Ile Phe Glu Gly Met Glu Cys Arg Gly Ser Pro Leu Val Val Ile Ser
435 440 445
Gln Gly Lys Ile Val Leu Glu Asp Gly Thr Leu His Val Thr Glu Gly
450 455 460
Ser Gly Arg Tyr Ile Pro Arg Lys Pro Phe Pro Asp Phe Val Tyr Lys
465 470 475 480
Arg Ile Lys Ala Arg Ser Arg Leu Ala Glu Leu Arg Gly Val Pro Arg
485 490 495
Gly Leu Tyr Asp Gly Pro Val Cys Glu Val Ser Val Thr Pro Lys Thr
500 505 510
Val Thr Pro Ala Ser Ser Ala Lys Thr Ser Pro Ala Lys Gln Gln Ala
515 520 525
Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Ala
530 535 540
Gln Ile Asp Asp Asn Ile Pro Arg Arg Thr Thr Gln Arg Ile Val Ala
545 550 555 560
Pro Pro Gly Gly Arg Ala Asn Ile Thr Ser Leu Gly
565 570
<210> 98
<211> 2115
<212> PRT
<213> 智人(Homo sapiens)
<400> 98
Met Thr Leu His Ala Thr Arg Gly Ala Ala Leu Leu Ser Trp Val Asn
1 5 10 15
Ser Leu His Val Ala Asp Pro Val Glu Ala Val Leu Gln Leu Gln Asp
20 25 30
Cys Ser Ile Phe Ile Lys Ile Ile Asp Arg Ile His Gly Thr Glu Glu
35 40 45
Gly Gln Gln Ile Leu Lys Gln Pro Val Ser Glu Arg Leu Asp Phe Val
50 55 60
Cys Ser Phe Leu Gln Lys Asn Arg Lys His Pro Ser Ser Pro Glu Cys
65 70 75 80
Leu Val Ser Ala Gln Lys Val Leu Glu Gly Ser Glu Leu Glu Leu Ala
85 90 95
Lys Met Thr Met Leu Leu Leu Tyr His Ser Thr Met Ser Ser Lys Ser
100 105 110
Pro Arg Asp Trp Glu Gln Phe Glu Tyr Lys Ile Gln Ala Glu Leu Ala
115 120 125
Val Ile Leu Lys Phe Val Leu Asp His Glu Asp Gly Leu Asn Leu Asn
130 135 140
Glu Asp Leu Glu Asn Phe Leu Gln Lys Ala Pro Val Pro Ser Thr Cys
145 150 155 160
Ser Ser Thr Phe Pro Glu Glu Leu Ser Pro Pro Ser His Gln Ala Lys
165 170 175
Arg Glu Ile Arg Phe Leu Glu Leu Gln Lys Val Ala Ser Ser Ser Ser
180 185 190
Gly Asn Asn Phe Leu Ser Gly Ser Pro Ala Ser Pro Met Gly Asp Ile
195 200 205
Leu Gln Thr Pro Gln Phe Gln Met Arg Arg Leu Lys Lys Gln Leu Ala
210 215 220
Asp Glu Arg Ser Asn Arg Asp Glu Leu Glu Leu Glu Leu Ala Glu Asn
225 230 235 240
Arg Lys Leu Leu Thr Glu Lys Asp Ala Gln Ile Ala Met Met Gln Gln
245 250 255
Arg Ile Asp Arg Leu Ala Leu Leu Asn Glu Lys Gln Ala Ala Ser Pro
260 265 270
Leu Glu Pro Lys Glu Leu Glu Glu Leu Arg Asp Lys Asn Glu Ser Leu
275 280 285
Thr Met Arg Leu His Glu Thr Leu Lys Gln Cys Gln Asp Leu Lys Thr
290 295 300
Glu Lys Ser Gln Met Asp Arg Lys Ile Asn Gln Leu Ser Glu Glu Asn
305 310 315 320
Gly Asp Leu Ser Phe Lys Leu Arg Glu Phe Ala Ser His Leu Gln Gln
325 330 335
Leu Gln Asp Ala Leu Asn Glu Leu Thr Glu Glu His Ser Lys Ala Thr
340 345 350
Gln Glu Trp Leu Glu Lys Gln Ala Gln Leu Glu Lys Glu Leu Ser Ala
355 360 365
Ala Leu Gln Asp Lys Lys Cys Leu Glu Glu Lys Asn Glu Ile Leu Gln
370 375 380
Gly Lys Leu Ser Gln Leu Glu Glu His Leu Ser Gln Leu Gln Asp Asn
385 390 395 400
Pro Pro Gln Glu Lys Gly Glu Val Leu Gly Asp Val Leu Gln Leu Glu
405 410 415
Thr Leu Lys Gln Glu Ala Ala Thr Leu Ala Ala Asn Asn Thr Gln Leu
420 425 430
Gln Ala Arg Val Glu Met Leu Glu Thr Glu Arg Gly Gln Gln Glu Ala
435 440 445
Lys Leu Leu Ala Glu Arg Gly His Phe Glu Glu Glu Lys Gln Gln Leu
450 455 460
Ser Ser Leu Ile Thr Asp Leu Gln Ser Ser Ile Ser Asn Leu Ser Gln
465 470 475 480
Ala Lys Glu Glu Leu Glu Gln Ala Ser Gln Ala His Gly Ala Arg Leu
485 490 495
Thr Ala Gln Val Ala Ser Leu Thr Ser Glu Leu Thr Thr Leu Asn Ala
500 505 510
Thr Ile Gln Gln Gln Asp Gln Glu Leu Ala Gly Leu Lys Gln Gln Ala
515 520 525
Lys Glu Lys Gln Ala Gln Leu Ala Gln Thr Leu Gln Gln Gln Glu Gln
530 535 540
Ala Ser Gln Gly Leu Arg His Gln Val Glu Gln Leu Ser Ser Ser Leu
545 550 555 560
Lys Gln Lys Glu Gln Gln Leu Lys Glu Val Ala Glu Lys Gln Glu Ala
565 570 575
Thr Arg Gln Asp His Ala Gln Gln Leu Ala Thr Ala Ala Glu Glu Arg
580 585 590
Glu Ala Ser Leu Arg Glu Arg Asp Ala Ala Leu Lys Gln Leu Glu Ala
595 600 605
Leu Glu Lys Glu Lys Ala Ala Lys Leu Glu Ile Leu Gln Gln Gln Leu
610 615 620
Gln Val Ala Asn Glu Ala Arg Asp Ser Ala Gln Thr Ser Val Thr Gln
625 630 635 640
Ala Gln Arg Glu Lys Ala Glu Leu Ser Arg Lys Val Glu Glu Leu Gln
645 650 655
Ala Cys Val Glu Thr Ala Arg Gln Glu Gln His Glu Ala Gln Ala Gln
660 665 670
Val Ala Glu Leu Glu Leu Gln Leu Arg Ser Glu Gln Gln Lys Ala Thr
675 680 685
Glu Lys Glu Arg Val Ala Gln Glu Lys Asp Gln Leu Gln Glu Gln Leu
690 695 700
Gln Ala Leu Lys Glu Ser Leu Lys Val Thr Lys Gly Ser Leu Glu Glu
705 710 715 720
Glu Lys Arg Arg Ala Ala Asp Ala Leu Glu Glu Gln Gln Arg Cys Ile
725 730 735
Ser Glu Leu Lys Ala Glu Thr Arg Ser Leu Val Glu Gln His Lys Arg
740 745 750
Glu Arg Lys Glu Leu Glu Glu Glu Arg Ala Gly Arg Lys Gly Leu Glu
755 760 765
Ala Arg Leu Gln Gln Leu Gly Glu Ala His Gln Ala Glu Thr Glu Val
770 775 780
Leu Arg Arg Glu Leu Ala Glu Ala Met Ala Ala Gln His Thr Ala Glu
785 790 795 800
Ser Glu Cys Glu Gln Leu Val Lys Glu Val Ala Ala Trp Arg Glu Arg
805 810 815
Tyr Glu Asp Ser Gln Gln Glu Glu Ala Gln Tyr Gly Ala Met Phe Gln
820 825 830
Glu Gln Leu Met Thr Leu Lys Glu Glu Cys Glu Lys Ala Arg Gln Glu
835 840 845
Leu Gln Glu Ala Lys Glu Lys Val Ala Gly Ile Glu Ser His Ser Glu
850 855 860
Leu Gln Ile Ser Arg Gln Gln Asn Glu Leu Ala Glu Leu His Ala Asn
865 870 875 880
Leu Ala Arg Ala Leu Gln Gln Val Gln Glu Lys Glu Val Arg Ala Gln
885 890 895
Lys Leu Ala Asp Asp Leu Ser Thr Leu Gln Glu Lys Met Ala Ala Thr
900 905 910
Ser Lys Glu Val Ala Arg Leu Glu Thr Leu Val Arg Lys Ala Gly Glu
915 920 925
Gln Gln Glu Thr Ala Ser Arg Glu Leu Val Lys Glu Pro Ala Arg Ala
930 935 940
Gly Asp Arg Gln Pro Glu Trp Leu Glu Glu Gln Gln Gly Arg Gln Phe
945 950 955 960
Cys Ser Thr Gln Ala Ala Leu Gln Ala Met Glu Arg Glu Ala Glu Gln
965 970 975
Met Gly Asn Glu Leu Glu Arg Leu Arg Ala Ala Leu Met Glu Ser Gln
980 985 990
Gly Gln Gln Gln Glu Glu Arg Gly Gln Gln Glu Arg Glu Val Ala Arg
995 1000 1005
Leu Thr Gln Glu Arg Gly Arg Ala Gln Ala Asp Leu Ala Leu Glu
1010 1015 1020
Lys Ala Ala Arg Ala Glu Leu Glu Met Arg Leu Gln Asn Ala Leu
1025 1030 1035
Asn Glu Gln Arg Val Glu Phe Ala Thr Leu Gln Glu Ala Leu Ala
1040 1045 1050
His Ala Leu Thr Glu Lys Glu Gly Lys Asp Gln Glu Leu Ala Lys
1055 1060 1065
Leu Arg Gly Leu Glu Ala Ala Gln Ile Lys Glu Leu Glu Glu Leu
1070 1075 1080
Arg Gln Thr Val Lys Gln Leu Lys Glu Gln Leu Ala Lys Lys Glu
1085 1090 1095
Lys Glu His Ala Ser Gly Ser Gly Ala Gln Ser Glu Ala Ala Gly
1100 1105 1110
Arg Thr Glu Pro Thr Gly Pro Lys Leu Glu Ala Leu Arg Ala Glu
1115 1120 1125
Val Ser Lys Leu Glu Gln Gln Cys Gln Lys Gln Gln Glu Gln Ala
1130 1135 1140
Asp Ser Leu Glu Arg Ser Leu Glu Ala Glu Arg Ala Ser Arg Ala
1145 1150 1155
Glu Arg Asp Ser Ala Leu Glu Thr Leu Gln Gly Gln Leu Glu Glu
1160 1165 1170
Lys Ala Gln Glu Leu Gly His Ser Gln Ser Ala Leu Ala Ser Ala
1175 1180 1185
Gln Arg Glu Leu Ala Ala Phe Arg Thr Lys Val Gln Asp His Ser
1190 1195 1200
Lys Ala Glu Asp Glu Trp Lys Ala Gln Val Ala Arg Gly Arg Gln
1205 1210 1215
Glu Ala Glu Arg Lys Asn Ser Leu Ile Ser Ser Leu Glu Glu Glu
1220 1225 1230
Val Ser Ile Leu Asn Arg Gln Val Leu Glu Lys Glu Gly Glu Ser
1235 1240 1245
Lys Glu Leu Lys Arg Leu Val Met Ala Glu Ser Glu Lys Ser Gln
1250 1255 1260
Lys Leu Glu Glu Arg Leu Arg Leu Leu Gln Ala Glu Thr Ala Ser
1265 1270 1275
Asn Ser Ala Arg Ala Ala Glu Arg Ser Ser Ala Leu Arg Glu Glu
1280 1285 1290
Val Gln Ser Leu Arg Glu Glu Ala Glu Lys Gln Arg Val Ala Ser
1295 1300 1305
Glu Asn Leu Arg Gln Glu Leu Thr Ser Gln Ala Glu Arg Ala Glu
1310 1315 1320
Glu Leu Gly Gln Glu Leu Lys Ala Trp Gln Glu Lys Phe Phe Gln
1325 1330 1335
Lys Glu Gln Ala Leu Ser Thr Leu Gln Leu Glu His Thr Ser Thr
1340 1345 1350
Gln Ala Leu Val Ser Glu Leu Leu Pro Ala Lys His Leu Cys Gln
1355 1360 1365
Gln Leu Gln Ala Glu Gln Ala Ala Ala Glu Lys Arg His Arg Glu
1370 1375 1380
Glu Leu Glu Gln Ser Lys Gln Ala Ala Gly Gly Leu Arg Ala Glu
1385 1390 1395
Leu Leu Arg Ala Gln Arg Glu Leu Gly Glu Leu Ile Pro Leu Arg
1400 1405 1410
Gln Lys Val Ala Glu Gln Glu Arg Thr Ala Gln Gln Leu Arg Ala
1415 1420 1425
Glu Lys Ala Ser Tyr Ala Glu Gln Leu Ser Met Leu Lys Lys Ala
1430 1435 1440
His Gly Leu Leu Ala Glu Glu Asn Arg Gly Leu Gly Glu Arg Ala
1445 1450 1455
Asn Leu Gly Arg Gln Phe Leu Glu Val Glu Leu Asp Gln Ala Arg
1460 1465 1470
Glu Lys Tyr Val Gln Glu Leu Ala Ala Val Arg Ala Asp Ala Glu
1475 1480 1485
Thr Arg Leu Ala Glu Val Gln Arg Glu Ala Gln Ser Thr Ala Arg
1490 1495 1500
Glu Leu Glu Val Met Thr Ala Lys Tyr Glu Gly Ala Lys Val Lys
1505 1510 1515
Val Leu Glu Glu Arg Gln Arg Phe Gln Glu Glu Arg Gln Lys Leu
1520 1525 1530
Thr Ala Gln Val Glu Gln Leu Glu Val Phe Gln Arg Glu Gln Thr
1535 1540 1545
Lys Gln Val Glu Glu Leu Ser Lys Lys Leu Ala Asp Ser Asp Gln
1550 1555 1560
Ala Ser Lys Val Gln Gln Gln Lys Leu Lys Ala Val Gln Ala Gln
1565 1570 1575
Gly Gly Glu Ser Gln Gln Glu Ala Gln Arg Leu Gln Ala Gln Leu
1580 1585 1590
Asn Glu Leu Gln Ala Gln Leu Ser Gln Lys Glu Gln Ala Ala Glu
1595 1600 1605
His Tyr Lys Leu Gln Met Glu Lys Ala Lys Thr His Tyr Asp Ala
1610 1615 1620
Lys Lys Gln Gln Asn Gln Glu Leu Gln Glu Gln Leu Arg Ser Leu
1625 1630 1635
Glu Gln Leu Gln Lys Glu Asn Lys Glu Leu Arg Ala Glu Ala Glu
1640 1645 1650
Arg Leu Gly His Glu Leu Gln Gln Ala Gly Leu Lys Thr Lys Glu
1655 1660 1665
Ala Glu Gln Thr Cys Arg His Leu Thr Ala Gln Val Arg Ser Leu
1670 1675 1680
Glu Ala Gln Val Ala His Ala Asp Gln Gln Leu Arg Asp Leu Gly
1685 1690 1695
Lys Phe Gln Val Ala Thr Asp Ala Leu Lys Ser Arg Glu Pro Gln
1700 1705 1710
Ala Lys Pro Gln Leu Asp Leu Ser Ile Asp Ser Leu Asp Leu Ser
1715 1720 1725
Cys Glu Glu Gly Thr Pro Leu Ser Ile Thr Ser Lys Leu Pro Arg
1730 1735 1740
Thr Gln Pro Asp Gly Thr Ser Val Pro Gly Glu Pro Ala Ser Pro
1745 1750 1755
Ile Ser Gln Arg Leu Pro Pro Lys Val Glu Ser Leu Glu Ser Leu
1760 1765 1770
Tyr Phe Thr Pro Ile Pro Ala Arg Ser Gln Ala Pro Leu Glu Ser
1775 1780 1785
Ser Leu Asp Ser Leu Gly Asp Val Phe Leu Asp Ser Gly Arg Lys
1790 1795 1800
Thr Arg Ser Ala Arg Arg Arg Thr Thr Gln Ile Ile Asn Ile Thr
1805 1810 1815
Met Thr Lys Lys Leu Asp Val Glu Glu Pro Asp Ser Ala Asn Ser
1820 1825 1830
Ser Phe Tyr Ser Thr Arg Ser Ala Pro Ala Ser Gln Ala Ser Leu
1835 1840 1845
Arg Ala Thr Ser Ser Thr Gln Ser Leu Ala Arg Leu Gly Ser Pro
1850 1855 1860
Asp Tyr Gly Asn Ser Ala Leu Leu Ser Leu Pro Gly Tyr Arg Pro
1865 1870 1875
Thr Thr Arg Ser Ser Ala Arg Arg Ser Gln Ala Gly Val Ser Ser
1880 1885 1890
Gly Ala Pro Pro Gly Arg Asn Ser Phe Tyr Met Gly Thr Cys Gln
1895 1900 1905
Asp Glu Pro Glu Gln Leu Asp Asp Trp Asn Arg Ile Ala Glu Leu
1910 1915 1920
Gln Gln Arg Asn Arg Val Cys Pro Pro His Leu Lys Thr Cys Tyr
1925 1930 1935
Pro Leu Glu Ser Arg Pro Ser Leu Ser Leu Gly Thr Ile Thr Asp
1940 1945 1950
Glu Glu Met Lys Thr Gly Asp Pro Gln Glu Thr Leu Arg Arg Ala
1955 1960 1965
Ser Met Gln Pro Ile Gln Ile Ala Glu Gly Thr Gly Ile Thr Thr
1970 1975 1980
Arg Gln Gln Arg Lys Arg Val Ser Leu Glu Pro His Gln Gly Pro
1985 1990 1995
Gly Thr Pro Glu Ser Lys Lys Ala Thr Ser Cys Phe Pro Arg Pro
2000 2005 2010
Met Thr Pro Arg Asp Arg His Glu Gly Arg Lys Gln Ser Thr Thr
2015 2020 2025
Glu Ala Gln Lys Lys Ala Ala Pro Ala Ser Thr Lys Gln Ala Asp
2030 2035 2040
Arg Arg Gln Ser Met Ala Phe Ser Ile Leu Asn Thr Pro Lys Lys
2045 2050 2055
Leu Gly Asn Ser Leu Leu Arg Arg Gly Ala Ser Lys Lys Ala Leu
2060 2065 2070
Ser Lys Ala Ser Pro Asn Thr Arg Ser Gly Thr Arg Arg Ser Pro
2075 2080 2085
Arg Ile Ala Thr Thr Thr Ala Ser Ala Ala Thr Ala Ala Ala Ile
2090 2095 2100
Gly Ala Thr Pro Arg Ala Lys Gly Lys Ala Lys His
2105 2110 2115
<210> 99
<211> 1357
<212> PRT
<213> 智人(Homo sapiens)
<400> 99
Met Glu Phe Tyr Glu Ser Ala Tyr Phe Ile Val Leu Ile Pro Ser Ile
1 5 10 15
Val Ile Thr Val Ile Phe Leu Phe Phe Trp Leu Phe Met Lys Glu Thr
20 25 30
Leu Tyr Asp Glu Val Leu Ala Lys Gln Lys Arg Glu Gln Lys Leu Ile
35 40 45
Pro Thr Lys Thr Asp Lys Lys Lys Ala Glu Lys Lys Lys Asn Lys Lys
50 55 60
Lys Glu Ile Gln Asn Gly Asn Leu His Glu Ser Asp Ser Glu Ser Val
65 70 75 80
Pro Arg Asp Phe Lys Leu Ser Asp Ala Leu Ala Val Glu Asp Asp Gln
85 90 95
Val Ala Pro Val Pro Leu Asn Val Val Glu Thr Ser Ser Ser Val Arg
100 105 110
Glu Arg Lys Lys Lys Glu Lys Lys Gln Lys Pro Val Leu Glu Glu Gln
115 120 125
Val Ile Lys Glu Ser Asp Ala Ser Lys Ile Pro Gly Lys Lys Val Glu
130 135 140
Pro Val Pro Val Thr Lys Gln Pro Thr Pro Pro Ser Glu Ala Ala Ala
145 150 155 160
Ser Lys Lys Lys Pro Gly Gln Lys Lys Ser Lys Asn Gly Ser Asp Asp
165 170 175
Gln Asp Lys Lys Val Glu Thr Leu Met Val Pro Ser Lys Arg Gln Glu
180 185 190
Ala Leu Pro Leu His Gln Glu Thr Lys Gln Glu Ser Gly Ser Gly Lys
195 200 205
Lys Lys Ala Ser Ser Lys Lys Gln Lys Thr Glu Asn Val Phe Val Asp
210 215 220
Glu Pro Leu Ile His Ala Thr Thr Tyr Ile Pro Leu Met Asp Asn Ala
225 230 235 240
Asp Ser Ser Pro Val Val Asp Lys Arg Glu Val Ile Asp Leu Leu Lys
245 250 255
Pro Asp Gln Val Glu Gly Ile Gln Lys Ser Gly Thr Lys Lys Leu Lys
260 265 270
Thr Glu Thr Asp Lys Glu Asn Ala Glu Val Lys Phe Lys Asp Phe Leu
275 280 285
Leu Ser Leu Lys Thr Met Met Phe Ser Glu Asp Glu Ala Leu Cys Val
290 295 300
Val Asp Leu Leu Lys Glu Lys Ser Gly Val Ile Gln Asp Ala Leu Lys
305 310 315 320
Lys Ser Ser Lys Gly Glu Leu Thr Thr Leu Ile His Gln Leu Gln Glu
325 330 335
Lys Asp Lys Leu Leu Ala Ala Val Lys Glu Asp Ala Ala Ala Thr Lys
340 345 350
Asp Arg Cys Lys Gln Leu Thr Gln Glu Met Met Thr Glu Lys Glu Arg
355 360 365
Ser Asn Val Val Ile Thr Arg Met Lys Asp Arg Ile Gly Thr Leu Glu
370 375 380
Lys Glu His Asn Val Phe Gln Asn Lys Ile His Val Ser Tyr Gln Glu
385 390 395 400
Thr Gln Gln Met Gln Met Lys Phe Gln Gln Val Arg Glu Gln Met Glu
405 410 415
Ala Glu Ile Ala His Leu Lys Gln Glu Asn Gly Ile Leu Arg Asp Ala
420 425 430
Val Ser Asn Thr Thr Asn Gln Leu Glu Ser Lys Gln Ser Ala Glu Leu
435 440 445
Asn Lys Leu Arg Gln Asp Tyr Ala Arg Leu Val Asn Glu Leu Thr Glu
450 455 460
Lys Thr Gly Lys Leu Gln Gln Glu Glu Val Gln Lys Lys Asn Ala Glu
465 470 475 480
Gln Ala Ala Thr Gln Leu Lys Val Gln Leu Gln Glu Ala Glu Arg Arg
485 490 495
Trp Glu Glu Val Gln Ser Tyr Ile Arg Lys Arg Thr Ala Glu His Glu
500 505 510
Ala Ala Gln Gln Asp Leu Gln Ser Lys Phe Val Ala Lys Glu Asn Glu
515 520 525
Val Gln Ser Leu His Ser Lys Leu Thr Asp Thr Leu Val Ser Lys Gln
530 535 540
Gln Leu Glu Gln Arg Leu Met Gln Leu Met Glu Ser Glu Gln Lys Arg
545 550 555 560
Val Asn Lys Glu Glu Ser Leu Gln Met Gln Val Gln Asp Ile Leu Glu
565 570 575
Gln Asn Glu Ala Leu Lys Ala Gln Ile Gln Gln Phe His Ser Gln Ile
580 585 590
Ala Ala Gln Thr Ser Ala Ser Val Leu Ala Glu Glu Leu His Lys Val
595 600 605
Ile Ala Glu Lys Asp Lys Gln Ile Lys Gln Thr Glu Asp Ser Leu Ala
610 615 620
Ser Glu Arg Asp Arg Leu Thr Ser Lys Glu Glu Glu Leu Lys Asp Ile
625 630 635 640
Gln Asn Met Asn Phe Leu Leu Lys Ala Glu Val Gln Lys Leu Gln Ala
645 650 655
Leu Ala Asn Glu Gln Ala Ala Ala Ala His Glu Leu Glu Lys Met Gln
660 665 670
Gln Ser Val Tyr Val Lys Asp Asp Lys Ile Arg Leu Leu Glu Glu Gln
675 680 685
Leu Gln His Glu Ile Ser Asn Lys Met Glu Glu Phe Lys Ile Leu Asn
690 695 700
Asp Gln Asn Lys Ala Leu Lys Ser Glu Val Gln Lys Leu Gln Thr Leu
705 710 715 720
Val Ser Glu Gln Pro Asn Lys Asp Val Val Glu Gln Met Glu Lys Cys
725 730 735
Ile Gln Glu Lys Asp Glu Lys Leu Lys Thr Val Glu Glu Leu Leu Glu
740 745 750
Thr Gly Leu Ile Gln Val Ala Thr Lys Glu Glu Glu Leu Asn Ala Ile
755 760 765
Arg Thr Glu Asn Ser Ser Leu Thr Lys Glu Val Gln Asp Leu Lys Ala
770 775 780
Lys Gln Asn Asp Gln Val Ser Phe Ala Ser Leu Val Glu Glu Leu Lys
785 790 795 800
Lys Val Ile His Glu Lys Asp Gly Lys Ile Lys Ser Val Glu Glu Leu
805 810 815
Leu Glu Ala Glu Leu Leu Lys Val Ala Asn Lys Glu Lys Thr Val Gln
820 825 830
Asp Leu Lys Gln Glu Ile Lys Ala Leu Lys Glu Glu Ile Gly Asn Val
835 840 845
Gln Leu Glu Lys Ala Gln Gln Leu Ser Ile Thr Ser Lys Val Gln Glu
850 855 860
Leu Gln Asn Leu Leu Lys Gly Lys Glu Glu Gln Met Asn Thr Met Lys
865 870 875 880
Ala Val Leu Glu Glu Lys Glu Lys Asp Leu Ala Asn Thr Gly Lys Trp
885 890 895
Leu Gln Asp Leu Gln Glu Glu Asn Glu Ser Leu Lys Ala His Val Gln
900 905 910
Glu Val Ala Gln His Asn Leu Lys Glu Ala Ser Ser Ala Ser Gln Phe
915 920 925
Glu Glu Leu Glu Ile Val Leu Lys Glu Lys Glu Asn Glu Leu Lys Arg
930 935 940
Leu Glu Ala Met Leu Lys Glu Arg Glu Ser Asp Leu Ser Ser Lys Thr
945 950 955 960
Gln Leu Leu Gln Asp Val Gln Asp Glu Asn Lys Leu Phe Lys Ser Gln
965 970 975
Ile Glu Gln Leu Lys Gln Gln Asn Tyr Gln Gln Ala Ser Ser Phe Pro
980 985 990
Pro His Glu Glu Leu Leu Lys Val Ile Ser Glu Arg Glu Lys Glu Ile
995 1000 1005
Ser Gly Leu Trp Asn Glu Leu Asp Ser Leu Lys Asp Ala Val Glu
1010 1015 1020
His Gln Arg Lys Lys Asn Asn Asp Leu Arg Glu Lys Asn Trp Glu
1025 1030 1035
Ala Met Glu Ala Leu Ala Ser Thr Glu Lys Met Leu Gln Asp Lys
1040 1045 1050
Val Asn Lys Thr Ser Lys Glu Arg Gln Gln Gln Val Glu Ala Val
1055 1060 1065
Glu Leu Glu Ala Lys Glu Val Leu Lys Lys Leu Phe Pro Lys Val
1070 1075 1080
Ser Val Pro Ser Asn Leu Ser Tyr Gly Glu Trp Leu His Gly Phe
1085 1090 1095
Glu Lys Lys Ala Lys Glu Cys Met Ala Gly Thr Ser Gly Ser Glu
1100 1105 1110
Glu Val Lys Val Leu Glu His Lys Leu Lys Glu Ala Asp Glu Met
1115 1120 1125
His Thr Leu Leu Gln Leu Glu Cys Glu Lys Tyr Lys Ser Val Leu
1130 1135 1140
Ala Glu Thr Glu Gly Ile Leu Gln Lys Leu Gln Arg Ser Val Glu
1145 1150 1155
Gln Glu Glu Asn Lys Trp Lys Val Lys Val Asp Glu Ser His Lys
1160 1165 1170
Thr Ile Lys Gln Met Gln Ser Ser Phe Thr Ser Ser Glu Gln Glu
1175 1180 1185
Leu Glu Arg Leu Arg Ser Glu Asn Lys Asp Ile Glu Asn Leu Arg
1190 1195 1200
Arg Glu Arg Glu His Leu Glu Met Glu Leu Glu Lys Ala Glu Met
1205 1210 1215
Glu Arg Ser Thr Tyr Val Thr Glu Val Arg Glu Leu Lys Asp Leu
1220 1225 1230
Leu Thr Glu Leu Gln Lys Lys Leu Asp Asp Ser Tyr Ser Glu Ala
1235 1240 1245
Val Arg Gln Asn Glu Glu Leu Asn Leu Leu Lys Ala Gln Leu Asn
1250 1255 1260
Glu Thr Leu Thr Lys Leu Arg Thr Glu Gln Asn Glu Arg Gln Lys
1265 1270 1275
Val Ala Gly Asp Leu His Lys Ala Gln Gln Ser Leu Glu Leu Ile
1280 1285 1290
Gln Ser Lys Ile Val Lys Ala Ala Gly Asp Thr Thr Val Ile Glu
1295 1300 1305
Asn Ser Asp Val Ser Pro Glu Thr Glu Ser Ser Glu Lys Glu Thr
1310 1315 1320
Met Ser Val Ser Leu Asn Gln Thr Val Thr Gln Leu Gln Gln Leu
1325 1330 1335
Leu Gln Ala Val Asn Gln Gln Leu Thr Lys Glu Lys Glu His Tyr
1340 1345 1350
Gln Val Leu Glu
1355
<210> 100
<211> 393
<212> PRT
<213> 智人(Homo sapiens)
<400> 100
Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro
1 5 10 15
Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys Lys Ala Ala Ser Lys
20 25 30
Thr Leu Leu Glu Lys Ser Gln Phe Ser Asp Lys Pro Val Gln Asp Arg
35 40 45
Gly Leu Val Val Thr Asp Leu Lys Ala Glu Ser Val Val Leu Glu His
50 55 60
Arg Ser Tyr Cys Ser Ala Lys Ala Arg Asp Arg His Phe Ala Gly Asp
65 70 75 80
Val Leu Gly Tyr Val Thr Pro Trp Asn Ser His Gly Tyr Asp Val Thr
85 90 95
Lys Val Phe Gly Ser Lys Phe Thr Gln Ile Ser Pro Val Trp Leu Gln
100 105 110
Leu Lys Arg Arg Gly Arg Glu Met Phe Glu Val Thr Gly Leu His Asp
115 120 125
Val Asp Gln Gly Trp Met Arg Ala Val Arg Lys His Ala Lys Gly Leu
130 135 140
His Ile Val Pro Arg Leu Leu Phe Glu Asp Trp Thr Tyr Asp Asp Phe
145 150 155 160
Arg Asn Val Leu Asp Ser Glu Asp Glu Ile Glu Glu Leu Ser Lys Thr
165 170 175
Val Val Gln Val Ala Lys Asn Gln His Phe Asp Gly Phe Val Val Glu
180 185 190
Val Trp Asn Gln Leu Leu Ser Gln Lys Arg Val Gly Leu Ile His Met
195 200 205
Leu Thr His Leu Ala Glu Ala Leu His Gln Ala Arg Leu Leu Ala Leu
210 215 220
Leu Val Ile Pro Pro Ala Ile Thr Pro Gly Thr Asp Gln Leu Gly Met
225 230 235 240
Phe Thr His Lys Glu Phe Glu Gln Leu Ala Pro Val Leu Asp Gly Phe
245 250 255
Ser Leu Met Thr Tyr Asp Tyr Ser Thr Ala His Gln Pro Gly Pro Asn
260 265 270
Ala Pro Leu Ser Trp Val Arg Ala Cys Val Gln Val Leu Asp Pro Lys
275 280 285
Ser Lys Trp Arg Ser Lys Ile Leu Leu Gly Leu Asn Phe Tyr Gly Met
290 295 300
Asp Tyr Ala Thr Ser Lys Asp Ala Arg Glu Pro Val Val Gly Ala Arg
305 310 315 320
Tyr Ile Gln Thr Leu Lys Asp His Arg Pro Arg Met Val Trp Asp Ser
325 330 335
Gln Ala Ser Glu His Phe Phe Glu Tyr Lys Lys Ser Arg Ser Gly Arg
340 345 350
His Val Val Phe Tyr Pro Thr Leu Lys Ser Leu Gln Val Arg Leu Glu
355 360 365
Leu Ala Arg Glu Leu Gly Val Gly Val Ser Ile Trp Glu Leu Gly Gln
370 375 380
Gly Leu Asp Tyr Phe Tyr Asp Leu Leu
385 390
<210> 101
<211> 493
<212> PRT
<213> 智人(Homo sapiens)
<400> 101
Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys
1 5 10 15
Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly
20 25 30
Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys
35 40 45
Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His
50 55 60
Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn
65 70 75 80
Asn Glu Gln Pro Gln Gln Glu Thr Gln Pro Ala Glu Gly Thr Ser Gly
85 90 95
Ala Thr Thr Gly Val Val Ala Ala Ser Ser Met Ala Thr Ser Gly Val
100 105 110
Leu Pro Gly Gly Gly Phe Val Ala Ser Ala Ala Ala Val Ala Gly Pro
115 120 125
Glu Met Gln Thr Gly Arg Asn Asn Phe Val Ile Arg Arg Asn Pro Ala
130 135 140
Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala
145 150 155 160
Ala Gly Tyr Glu Gln Ser Glu His Asn Val Cys Gln Asp Ile Asp Glu
165 170 175
Cys Thr Ala Gly Thr His Asn Cys Arg Ala Asp Gln Val Cys Ile Asn
180 185 190
Leu Arg Gly Ser Phe Ala Cys Gln Cys Pro Pro Gly Tyr Gln Lys Arg
195 200 205
Gly Glu Gln Cys Val Asp Ile Asp Glu Cys Thr Ile Pro Pro Tyr Cys
210 215 220
His Gln Arg Cys Val Asn Thr Pro Gly Ser Phe Tyr Cys Gln Cys Ser
225 230 235 240
Pro Gly Phe Gln Leu Ala Ala Asn Asn Tyr Thr Cys Val Asp Ile Asn
245 250 255
Glu Cys Asp Ala Ser Asn Gln Cys Ala Gln Gln Cys Tyr Asn Ile Leu
260 265 270
Gly Ser Phe Ile Cys Gln Cys Asn Gln Gly Tyr Glu Leu Ser Ser Asp
275 280 285
Arg Leu Asn Cys Glu Asp Ile Asp Glu Cys Arg Thr Ser Ser Tyr Leu
290 295 300
Cys Gln Tyr Gln Cys Val Asn Glu Pro Gly Lys Phe Ser Cys Met Cys
305 310 315 320
Pro Gln Gly Tyr Gln Val Val Arg Ser Arg Thr Cys Gln Asp Ile Asn
325 330 335
Glu Cys Glu Thr Thr Asn Glu Cys Arg Glu Asp Glu Met Cys Trp Asn
340 345 350
Tyr His Gly Gly Phe Arg Cys Tyr Pro Arg Asn Pro Cys Gln Asp Pro
355 360 365
Tyr Ile Leu Thr Pro Glu Asn Arg Cys Val Cys Pro Val Ser Asn Ala
370 375 380
Met Cys Arg Glu Leu Pro Gln Ser Ile Val Tyr Lys Tyr Met Ser Ile
385 390 395 400
Arg Ser Asp Arg Ser Val Pro Ser Asp Ile Phe Gln Ile Gln Ala Thr
405 410 415
Thr Ile Tyr Ala Asn Thr Ile Asn Thr Phe Arg Ile Lys Ser Gly Asn
420 425 430
Glu Asn Gly Glu Phe Tyr Leu Arg Gln Thr Ser Pro Val Ser Ala Met
435 440 445
Leu Val Leu Val Lys Ser Leu Ser Gly Pro Arg Glu His Ile Val Asp
450 455 460
Leu Glu Met Leu Thr Val Ser Ser Ile Gly Thr Phe Arg Thr Ser Ser
465 470 475 480
Val Leu Arg Leu Thr Ile Ile Val Gly Pro Phe Ser Phe
485 490
<210> 102
<211> 245
<212> PRT
<213> 智人(Homo sapiens)
<400> 102
Met Asp Lys Asn Glu Leu Val Gln Lys Ala Lys Leu Ala Glu Gln Ala
1 5 10 15
Glu Arg Tyr Asp Asp Met Ala Ala Cys Met Lys Ser Val Thr Glu Gln
20 25 30
Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr
35 40 45
Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Val Ser Ser
50 55 60
Ile Glu Gln Lys Thr Glu Gly Ala Glu Lys Lys Gln Gln Met Ala Arg
65 70 75 80
Glu Tyr Arg Glu Lys Ile Glu Thr Glu Leu Arg Asp Ile Cys Asn Asp
85 90 95
Val Leu Ser Leu Leu Glu Lys Phe Leu Ile Pro Asn Ala Ser Gln Ala
100 105 110
Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr
115 120 125
Leu Ala Glu Val Ala Ala Gly Asp Asp Lys Lys Gly Ile Val Asp Gln
130 135 140
Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys Glu Met
145 150 155 160
Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val
165 170 175
Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser Leu Ala
180 185 190
Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Ser Glu
195 200 205
Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn
210 215 220
Leu Thr Leu Trp Thr Ser Asp Thr Gln Gly Asp Glu Ala Glu Ala Gly
225 230 235 240
Glu Gly Gly Glu Asn
245
<210> 103
<211> 334
<212> PRT
<213> 智人(Homo sapiens)
<400> 103
Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu
1 5 10 15
Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val
20 25 30
Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu
35 40 45
Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met
50 55 60
Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala
65 70 75 80
Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr
85 90 95
Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln
100 105 110
Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr
115 120 125
Ser Pro Asp Cys Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu
130 135 140
Thr Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile
145 150 155 160
Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala
165 170 175
Glu Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly
180 185 190
Glu His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala
195 200 205
Gly Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp
210 215 220
Ser Glu Asn Trp Lys Glu Val His Lys Met Val Val Glu Ser Ala Tyr
225 230 235 240
Glu Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser
245 250 255
Val Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His
260 265 270
Pro Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val
275 280 285
Phe Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val
290 295 300
Ile Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser
305 310 315 320
Ala Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu
325 330
<210> 104
<211> 298
<212> PRT
<213> 智人(Homo sapiens)
<400> 104
Met Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp Lys Val Ile
1 5 10 15
Gln Ala Gln Thr Ala Phe Ser Ala Asn Pro Ala Asn Pro Ala Ile Leu
20 25 30
Ser Glu Ala Ser Ala Pro Ile Pro His Asp Gly Asn Leu Tyr Pro Arg
35 40 45
Leu Tyr Pro Glu Leu Ser Gln Tyr Met Gly Leu Ser Leu Asn Glu Glu
50 55 60
Glu Ile Arg Ala Asn Val Ala Val Val Ser Gly Ala Pro Leu Gln Gly
65 70 75 80
Gln Leu Val Ala Arg Pro Ser Ser Ile Asn Tyr Met Val Ala Pro Val
85 90 95
Thr Gly Asn Asp Val Gly Ile Arg Arg Ala Glu Ile Lys Gln Gly Ile
100 105 110
Arg Glu Val Ile Leu Cys Lys Asp Gln Asp Gly Lys Ile Gly Leu Arg
115 120 125
Leu Lys Ser Ile Asp Asn Gly Ile Phe Val Gln Leu Val Gln Ala Asn
130 135 140
Ser Pro Ala Ser Leu Val Gly Leu Arg Phe Gly Asp Gln Val Leu Gln
145 150 155 160
Ile Asn Gly Glu Asn Cys Ala Gly Trp Ser Ser Asp Lys Ala His Lys
165 170 175
Val Leu Lys Gln Ala Phe Gly Glu Lys Ile Thr Met Thr Ile Arg Asp
180 185 190
Arg Pro Phe Glu Arg Thr Ile Thr Met His Lys Asp Ser Thr Gly His
195 200 205
Val Gly Phe Ile Phe Lys Asn Gly Lys Ile Thr Ser Ile Val Lys Asp
210 215 220
Ser Ser Ala Ala Arg Asn Gly Leu Leu Thr Glu His Asn Ile Cys Glu
225 230 235 240
Ile Asn Gly Gln Asn Val Ile Gly Leu Lys Asp Ser Gln Ile Ala Asp
245 250 255
Ile Leu Ser Thr Ser Gly Thr Val Val Thr Ile Thr Ile Met Pro Ala
260 265 270
Phe Ile Phe Glu His Ile Ile Lys Arg Met Ala Pro Ser Ile Met Lys
275 280 285
Ser Leu Met Asp His Thr Ile Pro Glu Val
290 295
<210> 105
<211> 2541
<212> PRT
<213> 智人(Homo sapiens)
<400> 105
Met Val Ala Leu Ser Leu Lys Ile Ser Ile Gly Asn Val Val Lys Thr
1 5 10 15
Met Gln Phe Glu Pro Ser Thr Met Val Tyr Asp Ala Cys Arg Ile Ile
20 25 30
Arg Glu Arg Ile Pro Glu Ala Pro Ala Gly Pro Pro Ser Asp Phe Gly
35 40 45
Leu Phe Leu Ser Asp Asp Asp Pro Lys Lys Gly Ile Trp Leu Glu Ala
50 55 60
Gly Lys Ala Leu Asp Tyr Tyr Met Leu Arg Asn Gly Asp Thr Met Glu
65 70 75 80
Tyr Arg Lys Lys Gln Arg Pro Leu Lys Ile Arg Met Leu Asp Gly Thr
85 90 95
Val Lys Thr Ile Met Val Asp Asp Ser Lys Thr Val Thr Asp Met Leu
100 105 110
Met Thr Ile Cys Ala Arg Ile Gly Ile Thr Asn His Asp Glu Tyr Ser
115 120 125
Leu Val Arg Glu Leu Met Glu Glu Lys Lys Glu Glu Ile Thr Gly Thr
130 135 140
Leu Arg Lys Asp Lys Thr Leu Leu Arg Asp Glu Lys Lys Met Glu Lys
145 150 155 160
Leu Lys Gln Lys Leu His Thr Asp Asp Glu Leu Asn Trp Leu Asp His
165 170 175
Gly Arg Thr Leu Arg Glu Gln Gly Val Glu Glu His Glu Thr Leu Leu
180 185 190
Leu Arg Arg Lys Phe Phe Tyr Ser Asp Gln Asn Val Asp Ser Arg Asp
195 200 205
Pro Val Gln Leu Asn Leu Leu Tyr Val Gln Ala Arg Asp Asp Ile Leu
210 215 220
Asn Gly Ser His Pro Val Ser Phe Asp Lys Ala Cys Glu Phe Ala Gly
225 230 235 240
Phe Gln Cys Gln Ile Gln Phe Gly Pro His Asn Glu Gln Lys His Lys
245 250 255
Ala Gly Phe Leu Asp Leu Lys Asp Phe Leu Pro Lys Glu Tyr Val Lys
260 265 270
Gln Lys Gly Glu Arg Lys Ile Phe Gln Ala His Lys Asn Cys Gly Gln
275 280 285
Met Ser Glu Ile Glu Ala Lys Val Arg Tyr Val Lys Leu Ala Arg Ser
290 295 300
Leu Lys Thr Tyr Gly Val Ser Phe Phe Leu Val Lys Glu Lys Met Lys
305 310 315 320
Gly Lys Asn Lys Leu Val Pro Arg Leu Leu Gly Ile Thr Lys Glu Cys
325 330 335
Val Met Arg Val Asp Glu Lys Thr Lys Glu Val Ile Gln Glu Trp Asn
340 345 350
Leu Thr Asn Ile Lys Arg Trp Ala Ala Ser Pro Lys Ser Phe Thr Leu
355 360 365
Asp Phe Gly Asp Tyr Gln Asp Gly Tyr Tyr Ser Val Gln Thr Thr Glu
370 375 380
Gly Glu Gln Ile Ala Gln Leu Ile Ala Gly Tyr Ile Asp Ile Ile Leu
385 390 395 400
Lys Lys Lys Lys Ser Lys Asp His Phe Gly Leu Glu Gly Asp Glu Glu
405 410 415
Ser Thr Met Leu Glu Asp Ser Val Ser Pro Lys Lys Ser Thr Val Leu
420 425 430
Gln Gln Gln Tyr Asn Arg Val Gly Lys Val Glu His Gly Ser Val Ala
435 440 445
Leu Pro Ala Ile Met Arg Ser Gly Ala Ser Gly Pro Glu Asn Phe Gln
450 455 460
Val Gly Ser Met Pro Pro Ala Gln Gln Gln Ile Thr Ser Gly Gln Met
465 470 475 480
His Arg Gly His Met Pro Pro Leu Thr Ser Ala Gln Gln Ala Leu Thr
485 490 495
Gly Thr Ile Asn Ser Ser Met Gln Ala Val Gln Ala Ala Gln Ala Thr
500 505 510
Leu Asp Asp Phe Asp Thr Leu Pro Pro Leu Gly Gln Asp Ala Ala Ser
515 520 525
Lys Ala Trp Arg Lys Asn Lys Met Asp Glu Ser Lys His Glu Ile His
530 535 540
Ser Gln Val Asp Ala Ile Thr Ala Gly Thr Ala Ser Val Val Asn Leu
545 550 555 560
Thr Ala Gly Asp Pro Ala Glu Thr Asp Tyr Thr Ala Val Gly Cys Ala
565 570 575
Val Thr Thr Ile Ser Ser Asn Leu Thr Glu Met Ser Arg Gly Val Lys
580 585 590
Leu Leu Ala Ala Leu Leu Glu Asp Glu Gly Gly Ser Gly Arg Pro Leu
595 600 605
Leu Gln Ala Ala Lys Gly Leu Ala Gly Ala Val Ser Glu Leu Leu Arg
610 615 620
Ser Ala Gln Pro Ala Ser Ala Glu Pro Arg Gln Asn Leu Leu Gln Ala
625 630 635 640
Ala Gly Asn Val Gly Gln Ala Ser Gly Glu Leu Leu Gln Gln Ile Gly
645 650 655
Glu Ser Asp Thr Asp Pro His Phe Gln Asp Ala Leu Met Gln Leu Ala
660 665 670
Lys Ala Val Ala Ser Ala Ala Ala Ala Leu Val Leu Lys Ala Lys Ser
675 680 685
Val Ala Gln Arg Thr Glu Asp Ser Gly Leu Gln Thr Gln Val Ile Ala
690 695 700
Ala Ala Thr Gln Cys Ala Leu Ser Thr Ser Gln Leu Val Ala Cys Thr
705 710 715 720
Lys Val Val Ala Pro Thr Ile Ser Ser Pro Val Cys Gln Glu Gln Leu
725 730 735
Val Glu Ala Gly Arg Leu Val Ala Lys Ala Val Glu Gly Cys Val Ser
740 745 750
Ala Ser Gln Ala Ala Thr Glu Asp Gly Gln Leu Leu Arg Gly Val Gly
755 760 765
Ala Ala Ala Thr Ala Val Thr Gln Ala Leu Asn Glu Leu Leu Gln His
770 775 780
Val Lys Ala His Ala Thr Gly Ala Gly Pro Ala Gly Arg Tyr Asp Gln
785 790 795 800
Ala Thr Asp Thr Ile Leu Thr Val Thr Glu Asn Ile Phe Ser Ser Met
805 810 815
Gly Asp Ala Gly Glu Met Val Arg Gln Ala Arg Ile Leu Ala Gln Ala
820 825 830
Thr Ser Asp Leu Val Asn Ala Ile Lys Ala Asp Ala Glu Gly Glu Ser
835 840 845
Asp Leu Glu Asn Ser Arg Lys Leu Leu Ser Ala Ala Lys Ile Leu Ala
850 855 860
Asp Ala Thr Ala Lys Met Val Glu Ala Ala Lys Gly Ala Ala Ala His
865 870 875 880
Pro Asp Ser Glu Glu Gln Gln Gln Arg Leu Arg Glu Ala Ala Glu Gly
885 890 895
Leu Arg Met Ala Thr Asn Ala Ala Ala Gln Asn Ala Ile Lys Lys Lys
900 905 910
Leu Val Gln Arg Leu Glu His Ala Ala Lys Gln Ala Ala Ala Ser Ala
915 920 925
Thr Gln Thr Ile Ala Ala Ala Gln His Ala Ala Ser Thr Pro Lys Ala
930 935 940
Ser Ala Gly Pro Gln Pro Leu Leu Val Gln Ser Cys Lys Ala Val Ala
945 950 955 960
Glu Gln Ile Pro Leu Leu Val Gln Gly Val Arg Gly Ser Gln Ala Gln
965 970 975
Pro Asp Ser Pro Ser Ala Gln Leu Ala Leu Ile Ala Ala Ser Gln Ser
980 985 990
Phe Leu Gln Pro Gly Gly Lys Met Val Ala Ala Ala Lys Ala Ser Val
995 1000 1005
Pro Thr Ile Gln Asp Gln Ala Ser Ala Met Gln Leu Ser Gln Cys
1010 1015 1020
Ala Lys Asn Leu Gly Thr Ala Leu Ala Glu Leu Arg Thr Ala Ala
1025 1030 1035
Gln Lys Ala Gln Glu Ala Cys Gly Pro Leu Glu Met Asp Ser Ala
1040 1045 1050
Leu Ser Val Val Gln Asn Leu Glu Lys Asp Leu Gln Glu Val Lys
1055 1060 1065
Ala Ala Ala Arg Asp Gly Lys Leu Lys Pro Leu Pro Gly Glu Thr
1070 1075 1080
Met Glu Lys Cys Thr Gln Asp Leu Gly Asn Ser Thr Lys Ala Val
1085 1090 1095
Ser Ser Ala Ile Ala Gln Leu Leu Gly Glu Val Ala Gln Gly Asn
1100 1105 1110
Glu Asn Tyr Ala Gly Ile Ala Ala Arg Asp Val Ala Gly Gly Leu
1115 1120 1125
Arg Ser Leu Ala Gln Ala Ala Arg Gly Val Ala Ala Leu Thr Ser
1130 1135 1140
Asp Pro Ala Val Gln Ala Ile Val Leu Asp Thr Ala Ser Asp Val
1145 1150 1155
Leu Asp Lys Ala Ser Ser Leu Ile Glu Glu Ala Lys Lys Ala Ala
1160 1165 1170
Gly His Pro Gly Asp Pro Glu Ser Gln Gln Arg Leu Ala Gln Val
1175 1180 1185
Ala Lys Ala Val Thr Gln Ala Leu Asn Arg Cys Val Ser Cys Leu
1190 1195 1200
Pro Gly Gln Arg Asp Val Asp Asn Ala Leu Arg Ala Val Gly Asp
1205 1210 1215
Ala Ser Lys Arg Leu Leu Ser Asp Ser Leu Pro Pro Ser Thr Gly
1220 1225 1230
Thr Phe Gln Glu Ala Gln Ser Arg Leu Asn Glu Ala Ala Ala Gly
1235 1240 1245
Leu Asn Gln Ala Ala Thr Glu Leu Val Gln Ala Ser Arg Gly Thr
1250 1255 1260
Pro Gln Asp Leu Ala Arg Ala Ser Gly Arg Phe Gly Gln Asp Phe
1265 1270 1275
Ser Thr Phe Leu Glu Ala Gly Val Glu Met Ala Gly Gln Ala Pro
1280 1285 1290
Ser Gln Glu Asp Arg Ala Gln Val Val Ser Asn Leu Lys Gly Ile
1295 1300 1305
Ser Met Ser Ser Ser Lys Leu Leu Leu Ala Ala Lys Ala Leu Ser
1310 1315 1320
Thr Asp Pro Ala Ala Pro Asn Leu Lys Ser Gln Leu Ala Ala Ala
1325 1330 1335
Ala Arg Ala Val Thr Asp Ser Ile Asn Gln Leu Ile Thr Met Cys
1340 1345 1350
Thr Gln Gln Ala Pro Gly Gln Lys Glu Cys Asp Asn Ala Leu Arg
1355 1360 1365
Glu Leu Glu Thr Val Arg Glu Leu Leu Glu Asn Pro Val Gln Pro
1370 1375 1380
Ile Asn Asp Met Ser Tyr Phe Gly Cys Leu Asp Ser Val Met Glu
1385 1390 1395
Asn Ser Lys Val Leu Gly Glu Ala Met Thr Gly Ile Ser Gln Asn
1400 1405 1410
Ala Lys Asn Gly Asn Leu Pro Glu Phe Gly Asp Ala Ile Ser Thr
1415 1420 1425
Ala Ser Lys Ala Leu Cys Gly Phe Thr Glu Ala Ala Ala Gln Ala
1430 1435 1440
Ala Tyr Leu Val Gly Val Ser Asp Pro Asn Ser Gln Ala Gly Gln
1445 1450 1455
Gln Gly Leu Val Glu Pro Thr Gln Phe Ala Arg Ala Asn Gln Ala
1460 1465 1470
Ile Gln Met Ala Cys Gln Ser Leu Gly Glu Pro Gly Cys Thr Gln
1475 1480 1485
Ala Gln Val Leu Ser Ala Ala Thr Ile Val Ala Lys His Thr Ser
1490 1495 1500
Ala Leu Cys Asn Ser Cys Arg Leu Ala Ser Ala Arg Thr Thr Asn
1505 1510 1515
Pro Thr Ala Lys Arg Gln Phe Val Gln Ser Ala Lys Glu Val Ala
1520 1525 1530
Asn Ser Thr Ala Asn Leu Val Lys Thr Ile Lys Ala Leu Asp Gly
1535 1540 1545
Ala Phe Thr Glu Glu Asn Arg Ala Gln Cys Arg Ala Ala Thr Ala
1550 1555 1560
Pro Leu Leu Glu Ala Val Asp Asn Leu Ser Ala Phe Ala Ser Asn
1565 1570 1575
Pro Glu Phe Ser Ser Ile Pro Ala Gln Ile Ser Pro Glu Gly Arg
1580 1585 1590
Ala Ala Met Glu Pro Ile Val Ile Ser Ala Lys Thr Met Leu Glu
1595 1600 1605
Ser Ala Gly Gly Leu Ile Gln Thr Ala Arg Ala Leu Ala Val Asn
1610 1615 1620
Pro Arg Asp Pro Pro Ser Trp Ser Val Leu Ala Gly His Ser Arg
1625 1630 1635
Thr Val Ser Asp Ser Ile Lys Lys Leu Ile Thr Ser Met Arg Asp
1640 1645 1650
Lys Ala Pro Gly Gln Leu Glu Cys Glu Thr Ala Ile Ala Ala Leu
1655 1660 1665
Asn Ser Cys Leu Arg Asp Leu Asp Gln Ala Ser Leu Ala Ala Val
1670 1675 1680
Ser Gln Gln Leu Ala Pro Arg Glu Gly Ile Ser Gln Glu Ala Leu
1685 1690 1695
His Thr Gln Met Leu Thr Ala Val Gln Glu Ile Ser His Leu Ile
1700 1705 1710
Glu Pro Leu Ala Asn Ala Ala Arg Ala Glu Ala Ser Gln Leu Gly
1715 1720 1725
His Lys Val Ser Gln Met Ala Gln Tyr Phe Glu Pro Leu Thr Leu
1730 1735 1740
Ala Ala Val Gly Ala Ala Ser Lys Thr Leu Ser His Pro Gln Gln
1745 1750 1755
Met Ala Leu Leu Asp Gln Thr Lys Thr Leu Ala Glu Ser Ala Leu
1760 1765 1770
Gln Leu Leu Tyr Thr Ala Lys Glu Ala Gly Gly Asn Pro Lys Gln
1775 1780 1785
Ala Ala His Thr Gln Glu Ala Leu Glu Glu Ala Val Gln Met Met
1790 1795 1800
Thr Glu Ala Val Glu Asp Leu Thr Thr Thr Leu Asn Glu Ala Ala
1805 1810 1815
Ser Ala Ala Gly Val Val Gly Gly Met Val Asp Ser Ile Thr Gln
1820 1825 1830
Ala Ile Asn Gln Leu Asp Glu Gly Pro Met Gly Glu Pro Glu Gly
1835 1840 1845
Ser Phe Val Asp Tyr Gln Thr Thr Met Val Arg Thr Ala Lys Ala
1850 1855 1860
Ile Ala Val Thr Val Gln Glu Met Val Thr Lys Ser Asn Thr Ser
1865 1870 1875
Pro Glu Glu Leu Gly Pro Leu Ala Asn Gln Leu Thr Ser Asp Tyr
1880 1885 1890
Gly Arg Leu Ala Ser Glu Ala Lys Pro Ala Ala Val Ala Ala Glu
1895 1900 1905
Asn Glu Glu Ile Gly Ser His Ile Lys His Arg Val Gln Glu Leu
1910 1915 1920
Gly His Gly Cys Ala Ala Leu Val Thr Lys Ala Gly Ala Leu Gln
1925 1930 1935
Cys Ser Pro Ser Asp Ala Tyr Thr Lys Lys Glu Leu Ile Glu Cys
1940 1945 1950
Ala Arg Arg Val Ser Glu Lys Val Ser His Val Leu Ala Ala Leu
1955 1960 1965
Gln Ala Gly Asn Arg Gly Thr Gln Ala Cys Ile Thr Ala Ala Ser
1970 1975 1980
Ala Val Ser Gly Ile Ile Ala Asp Leu Asp Thr Thr Ile Met Phe
1985 1990 1995
Ala Thr Ala Gly Thr Leu Asn Arg Glu Gly Thr Glu Thr Phe Ala
2000 2005 2010
Asp His Arg Glu Gly Ile Leu Lys Thr Ala Lys Val Leu Val Glu
2015 2020 2025
Asp Thr Lys Val Leu Val Gln Asn Ala Ala Gly Ser Gln Glu Lys
2030 2035 2040
Leu Ala Gln Ala Ala Gln Ser Ser Val Ala Thr Ile Thr Arg Leu
2045 2050 2055
Ala Asp Val Val Lys Leu Gly Ala Ala Ser Leu Gly Ala Glu Asp
2060 2065 2070
Pro Glu Thr Gln Val Val Leu Ile Asn Ala Val Lys Asp Val Ala
2075 2080 2085
Lys Ala Leu Gly Asp Leu Ile Ser Ala Thr Lys Ala Ala Ala Gly
2090 2095 2100
Lys Val Gly Asp Asp Pro Ala Val Trp Gln Leu Lys Asn Ser Ala
2105 2110 2115
Lys Val Met Val Thr Asn Val Thr Ser Leu Leu Lys Thr Val Lys
2120 2125 2130
Ala Val Glu Asp Glu Ala Thr Lys Gly Thr Arg Ala Leu Glu Ala
2135 2140 2145
Thr Thr Glu His Ile Arg Gln Glu Leu Ala Val Phe Cys Ser Pro
2150 2155 2160
Glu Pro Pro Ala Lys Thr Ser Thr Pro Glu Asp Phe Ile Arg Met
2165 2170 2175
Thr Lys Gly Ile Thr Met Ala Thr Ala Lys Ala Val Ala Ala Gly
2180 2185 2190
Asn Ser Cys Arg Gln Glu Asp Val Ile Ala Thr Ala Asn Leu Ser
2195 2200 2205
Arg Arg Ala Ile Ala Asp Met Leu Arg Ala Cys Lys Glu Ala Ala
2210 2215 2220
Tyr His Pro Glu Val Ala Pro Asp Val Arg Leu Arg Ala Leu His
2225 2230 2235
Tyr Gly Arg Glu Cys Ala Asn Gly Tyr Leu Glu Leu Leu Asp His
2240 2245 2250
Val Leu Leu Thr Leu Gln Lys Pro Ser Pro Glu Leu Lys Gln Gln
2255 2260 2265
Leu Thr Gly His Ser Lys Arg Val Ala Gly Ser Val Thr Glu Leu
2270 2275 2280
Ile Gln Ala Ala Glu Ala Met Lys Gly Thr Glu Trp Val Asp Pro
2285 2290 2295
Glu Asp Pro Thr Val Ile Ala Glu Asn Glu Leu Leu Gly Ala Ala
2300 2305 2310
Ala Ala Ile Glu Ala Ala Ala Lys Lys Leu Glu Gln Leu Lys Pro
2315 2320 2325
Arg Ala Lys Pro Lys Glu Ala Asp Glu Ser Leu Asn Phe Glu Glu
2330 2335 2340
Gln Ile Leu Glu Ala Ala Lys Ser Ile Ala Ala Ala Thr Ser Ala
2345 2350 2355
Leu Val Lys Ala Ala Ser Ala Ala Gln Arg Glu Leu Val Ala Gln
2360 2365 2370
Gly Lys Val Gly Ala Ile Pro Ala Asn Ala Leu Asp Asp Gly Gln
2375 2380 2385
Trp Ser Gln Gly Leu Ile Ser Ala Ala Arg Met Val Ala Ala Ala
2390 2395 2400
Thr Asn Asn Leu Cys Glu Ala Ala Asn Ala Ala Val Gln Gly His
2405 2410 2415
Ala Ser Gln Glu Lys Leu Ile Ser Ser Ala Lys Gln Val Ala Ala
2420 2425 2430
Ser Thr Ala Gln Leu Leu Val Ala Cys Lys Val Lys Ala Asp Gln
2435 2440 2445
Asp Ser Glu Ala Met Lys Arg Leu Gln Ala Ala Gly Asn Ala Val
2450 2455 2460
Lys Arg Ala Ser Asp Asn Leu Val Lys Ala Ala Gln Lys Ala Ala
2465 2470 2475
Ala Phe Glu Glu Gln Glu Asn Glu Thr Val Val Val Lys Glu Lys
2480 2485 2490
Met Val Gly Gly Ile Ala Gln Ile Ile Ala Ala Gln Glu Glu Met
2495 2500 2505
Leu Arg Lys Glu Arg Glu Leu Glu Glu Ala Arg Lys Lys Leu Ala
2510 2515 2520
Gln Ile Arg Gln Gln Gln Tyr Lys Phe Leu Pro Ser Glu Leu Arg
2525 2530 2535
Asp Glu His
2540
<210> 106
<211> 470
<212> PRT
<213> 智人(Homo sapiens)
<400> 106
Met Ser Gln Ala Tyr Ser Ser Ser Gln Arg Val Ser Ser Tyr Arg Arg
1 5 10 15
Thr Phe Gly Gly Ala Pro Gly Phe Pro Leu Gly Ser Pro Leu Ser Ser
20 25 30
Pro Val Phe Pro Arg Ala Gly Phe Gly Ser Lys Gly Ser Ser Ser Ser
35 40 45
Val Thr Ser Arg Val Tyr Gln Val Ser Arg Thr Ser Gly Gly Ala Gly
50 55 60
Gly Leu Gly Ser Leu Arg Ala Ser Arg Leu Gly Thr Thr Arg Thr Pro
65 70 75 80
Ser Ser Tyr Gly Ala Gly Glu Leu Leu Asp Phe Ser Leu Ala Asp Ala
85 90 95
Val Asn Gln Glu Phe Leu Thr Thr Arg Thr Asn Glu Lys Val Glu Leu
100 105 110
Gln Glu Leu Asn Asp Arg Phe Ala Asn Tyr Ile Glu Lys Val Arg Phe
115 120 125
Leu Glu Gln Gln Asn Ala Ala Leu Ala Ala Glu Val Asn Arg Leu Lys
130 135 140
Gly Arg Glu Pro Thr Arg Val Ala Glu Leu Tyr Glu Glu Glu Leu Arg
145 150 155 160
Glu Leu Arg Arg Gln Val Glu Val Leu Thr Asn Gln Arg Ala Arg Val
165 170 175
Asp Val Glu Arg Asp Asn Leu Leu Asp Asp Leu Gln Arg Leu Lys Ala
180 185 190
Lys Leu Gln Glu Glu Ile Gln Leu Lys Glu Glu Ala Glu Asn Asn Leu
195 200 205
Ala Ala Phe Arg Ala Asp Val Asp Ala Ala Thr Leu Ala Arg Ile Asp
210 215 220
Leu Glu Arg Arg Ile Glu Ser Leu Asn Glu Glu Ile Ala Phe Leu Lys
225 230 235 240
Lys Val His Glu Glu Glu Ile Arg Glu Leu Gln Ala Gln Leu Gln Glu
245 250 255
Gln Gln Val Gln Val Glu Met Asp Met Ser Lys Pro Asp Leu Thr Ala
260 265 270
Ala Leu Arg Asp Ile Arg Ala Gln Tyr Glu Thr Ile Ala Ala Lys Asn
275 280 285
Ile Ser Glu Ala Glu Glu Trp Tyr Lys Ser Lys Val Ser Asp Leu Thr
290 295 300
Gln Ala Ala Asn Lys Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu
305 310 315 320
Met Met Glu Tyr Arg His Gln Ile Gln Ser Tyr Thr Cys Glu Ile Asp
325 330 335
Ala Leu Lys Gly Thr Asn Asp Ser Leu Met Arg Gln Met Arg Glu Leu
340 345 350
Glu Asp Arg Phe Ala Ser Glu Ala Ser Gly Tyr Gln Asp Asn Ile Ala
355 360 365
Arg Leu Glu Glu Glu Ile Arg His Leu Lys Asp Glu Met Ala Arg His
370 375 380
Leu Arg Glu Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Val
385 390 395 400
Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile
405 410 415
Asn Leu Pro Ile Gln Thr Tyr Ser Ala Leu Asn Phe Arg Glu Thr Ser
420 425 430
Pro Glu Gln Arg Gly Ser Glu Val His Thr Lys Lys Thr Val Met Ile
435 440 445
Lys Thr Ile Glu Thr Arg Asp Gly Glu Val Val Ser Glu Ala Thr Gln
450 455 460
Gln Gln His Glu Val Leu
465 470
<210> 107
<211> 770
<212> PRT
<213> 智人(Homo sapiens)
<400> 107
Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg
1 5 10 15
Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro
20 25 30
Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln
35 40 45
Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp
50 55 60
Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu
65 70 75 80
Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn
85 90 95
Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val
100 105 110
Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu
115 120 125
Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys
130 135 140
Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu
145 150 155 160
Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile
165 170 175
Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu
180 185 190
Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val
195 200 205
Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys
210 215 220
Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu
225 230 235 240
Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu
245 250 255
Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile
260 265 270
Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg
275 280 285
Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile
290 295 300
Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe
305 310 315 320
Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr
325 330 335
Cys Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr
340 345 350
Thr Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala
355 360 365
Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp
370 375 380
Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala
385 390 395 400
Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala
405 410 415
Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile
420 425 430
Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn
435 440 445
Glu Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met
450 455 460
Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu
465 470 475 480
Gln Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys
485 490 495
Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe
500 505 510
Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser
515 520 525
Gln Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser
530 535 540
Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp
545 550 555 560
Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val
565 570 575
Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala
580 585 590
Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro
595 600 605
Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe
610 615 620
Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val
625 630 635 640
Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser
645 650 655
Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp
660 665 670
Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu
675 680 685
Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly
690 695 700
Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu
705 710 715 720
Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val
725 730 735
Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met
740 745 750
Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met
755 760 765
Gln Asn
770
<210> 108
<211> 895
<212> PRT
<213> 智人(Homo sapiens)
<400> 108
Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Ser Gly Arg
1 5 10 15
Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro
20 25 30
Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala
35 40 45
Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val
50 55 60
Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val
65 70 75 80
Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val
85 90 95
Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser
100 105 110
Gln Ser His Thr Leu Glu Gly Leu Pro Leu Asp Thr Asp Lys Gly Val
115 120 125
His Tyr Ile Ser Val Ser Ala Thr Arg Leu Gly Ala Asn Gly Ser His
130 135 140
Ile Pro Gln Thr Ser Ser Val Phe Ser Ile Glu Val Tyr Pro Glu Asp
145 150 155 160
His Ser Glu Leu Gln Ser Val Arg Thr Ala Ser Pro Asp Pro Gly Glu
165 170 175
Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro Val Thr Val Leu Thr
180 185 190
Val Ile Leu Asp Ala Asp Leu Thr Lys Met Thr Pro Lys Gln Arg Ile
195 200 205
Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu Val Glu Leu His Asn
210 215 220
Met Lys Leu Val Pro Val Val Asn Asn Arg Leu Phe Asp Met Ser Ala
225 230 235 240
Phe Met Ala Gly Pro Gly Asn Ala Lys Lys Val Val Glu Asn Gly Ala
245 250 255
Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn Gln Asn Ser Val Pro
260 265 270
Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu Gly Ala Met Ser Ala
275 280 285
Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile Ala Asn Lys Lys Pro
290 295 300
Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His Ala Thr Pro Thr Pro
305 310 315 320
Val Thr Ala Ile Gly Pro Pro Thr Thr Ala Ile Gln Glu Pro Pro Ser
325 330 335
Arg Ile Val Pro Thr Pro Thr Ser Pro Ala Ile Ala Pro Pro Thr Glu
340 345 350
Thr Met Ala Pro Pro Val Arg Asp Pro Val Pro Gly Lys Pro Thr Val
355 360 365
Thr Ile Arg Thr Arg Gly Ala Ile Ile Gln Thr Pro Thr Leu Gly Pro
370 375 380
Ile Gln Pro Thr Arg Val Ser Glu Ala Gly Thr Thr Val Pro Gly Gln
385 390 395 400
Ile Arg Pro Thr Met Thr Ile Pro Gly Tyr Val Glu Pro Thr Ala Val
405 410 415
Ala Thr Pro Pro Thr Thr Thr Thr Lys Lys Pro Arg Val Ser Thr Pro
420 425 430
Lys Pro Ala Thr Pro Ser Thr Asp Ser Thr Thr Thr Thr Thr Arg Arg
435 440 445
Pro Thr Lys Lys Pro Arg Thr Pro Arg Pro Val Pro Arg Val Thr Thr
450 455 460
Lys Val Ser Ile Thr Arg Leu Glu Thr Ala Ser Pro Pro Thr Arg Ile
465 470 475 480
Arg Thr Thr Thr Ser Gly Val Pro Arg Gly Gly Glu Pro Asn Gln Arg
485 490 495
Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp Ala Trp Val Gly Thr
500 505 510
Tyr Phe Glu Val Lys Ile Pro Ser Asp Thr Phe Tyr Asp His Glu Asp
515 520 525
Thr Thr Thr Asp Lys Leu Lys Leu Thr Leu Lys Leu Arg Glu Gln Gln
530 535 540
Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn Ser Asn Ser Gln Leu
545 550 555 560
Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly Lys His Glu Tyr Phe
565 570 575
Met His Ala Thr Asp Lys Gly Gly Leu Ser Ala Val Asp Ala Phe Glu
580 585 590
Ile His Val His Arg Arg Pro Gln Gly Asp Arg Ala Pro Ala Arg Phe
595 600 605
Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val Leu Asn Asp Ile His
610 615 620
Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe Ala Phe Gly Asp Arg
625 630 635 640
Asn Cys Ser Thr Ile Thr Leu Gln Asn Ile Thr Arg Gly Ser Ile Val
645 650 655
Val Glu Trp Thr Asn Asn Thr Leu Pro Leu Glu Pro Cys Pro Lys Glu
660 665 670
Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu Asp Asp Gly Lys Pro
675 680 685
Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp Phe Lys Ala Thr Ser
690 695 700
Ile Thr Val Thr Gly Ser Gly Ser Cys Arg His Leu Gln Phe Ile Pro
705 710 715 720
Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala Pro Pro Thr Glu Val
725 730 735
Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp Asp Val Tyr Leu His
740 745 750
Thr Val Ile Pro Ala Val Val Val Ala Ala Ile Leu Leu Ile Ala Gly
755 760 765
Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg Lys Gly Lys Leu Thr
770 775 780
Leu Glu Asp Gln Ala Thr Phe Ile Lys Lys Gly Val Pro Ile Ile Phe
785 790 795 800
Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro Ser Ser Ser Met Pro
805 810 815
Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro Pro Pro Glu Tyr Pro
820 825 830
Asn Gln Ser Val Pro Glu Thr Thr Pro Leu Asn Gln Asp Thr Met Gly
835 840 845
Glu Tyr Thr Pro Leu Arg Asp Glu Asp Pro Asn Ala Pro Pro Tyr Gln
850 855 860
Pro Pro Pro Pro Phe Thr Ala Pro Met Glu Gly Lys Gly Ser Arg Pro
865 870 875 880
Lys Asn Met Thr Pro Tyr Arg Ser Pro Pro Pro Tyr Val Pro Pro
885 890 895
<210> 109
<211> 23
<212> RNA
<213> 智人(Homo sapiens)
<400> 109
uguaaacauc cuacacucuc agc 23
<210> 110
<211> 104
<212> DNA
<213> 智人(Homo sapiens)
<400> 110
attcttctat agttcatgag catgatgatt gggtgttcat gacatgtgtg agatgtgcca 60
ccctctgaac cttgttccca catcggcaca ttatccatct aacc 104
<210> 111
<211> 20
<212> RNA
<213> 智人(Homo sapiens)
<400> 111
agcccccugg ccccaaaccc 20
<210> 112
<211> 22
<212> RNA
<213> 智人(Homo sapiens)
<400> 112
uuguacaugg uaggcuuuca uu 22
<210> 113
<211> 21
<212> RNA
<213> 智人(Homo sapiens)
<400> 113
ucgaggagcu cacagucuag u 21
<210> 114
<211> 22
<212> RNA
<213> 智人(Homo sapiens)
<400> 114
uguaaacauc cccgacugga ag 22
<210> 115
<211> 22
<212> RNA
<213> 智人(Homo sapiens)
<400> 115
gaaguuguuc gugguggauu cg 22
<210> 116
<211> 22
<212> RNA
<213> 智人(Homo sapiens)
<400> 116
cuuucagucg gauguuugca gc 22
<210> 117
<211> 22
<212> RNA
<213> 智人(Homo sapiens)
<400> 117
ugagguagua guuuguacag uu 22
<210> 118
<211> 22
<212> RNA
<213> 智人(Homo sapiens)
<400> 118
auauaauaca accugcuaag ug 22
<210> 119
<211> 22
<212> RNA
<213> 智人(Homo sapiens)
<400> 119
uagcuuauca gacugauguu ga 22
<210> 120
<211> 22
<212> RNA
<213> 智人(Homo sapiens)
<400> 120
ugagguagua gauuguauag uu 22
<210> 121
<211> 21
<212> RNA
<213> 智人(Homo sapiens)
<400> 121
gcuggucugc guggugcucg g 21
<210> 122
<211> 22
<212> RNA
<213> 智人(Homo sapiens)
<400> 122
uauguaacac gguccacuaa cc 22

Claims (15)

1.一种对受试者的神经病症进行诊断或预后的方法，所述方法包括以下步骤：
(a)确定来自所述受试者的生物样品中一种或多种生物标志物的定量或定性水平；以及
(b)基于所述生物样品中所述或每种生物标志物的所述定量或定性水平对所述受试者的所述神经病症进行诊断或预后；
其中所述或每种生物标志物选自：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；COL5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；CAPRIN1；DES；APP；以及DAG1。
2.根据权利要求1所述的方法，其中所述确定步骤(a)包括确定来自所述受试者的所述生物样品中的所有所述生物标志物的定量或定性水平。
3.根据权利要求1或2所述的方法，其中所述确定步骤(a)包括确定来自所述受试者的所述生物样品中的每种所述生物标志物的定量或定性水平。
4.根据权利要求1-3中任一项所述的方法，其中所述或每种生物标志物是基因。
5.根据权利要求4所述的方法，其中所述或每种生物标志物是选自以下的基因：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；DES；APP；以及DAG1。
6.根据权利要求1-3中任一项所述的方法，其中所述或每种生物标志物是由选自以下的基因编码的蛋白质：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；HSPA5；NCL；TPM1；TNC；IGFBP3；C0L5A1；CLEC11A；MAP1B；NACA；PSMA2；RPL5；MYL6；CTSB；HSPD1；PTRF；NUCB1；PDIA4；P4HB；ACTN4；CAPRIN1；DES；APP；以及DAG1。
7.根据权利要求6所述的方法，其中所述或每种生物标志物是由选自以下的基因编码的蛋白质：PDIA3；CCDC80；HSPA8；SERPINE2；PLEC；以及DAG1。
8.根据权利要求6所述的方法，其中所述或每种生物标志物是具有选自以下的UniProtKB/Swiss-Prot登录号的蛋白质：P30101；Q76M96；P11142；P07093；Q15149；P11021；P19338；P09493；P24821；P17936；P20908；Q9Y240；P46821；Q13765；P25787；P46777；P60660；P07858；P10809；Q6NZI2；Q02818；P13667；P07237；043707；Q14444；P17661；P05067；以及Q14118。
9.根据权利要求8所述的方法，其中所述或每种生物标志物是具有选自以下的UniProtKB/Swiss-Prot登录号的蛋白质：P30101；Q76M96；P11142；P07093；Q15149；P17661；P05067；以及Q14118。
10.根据权利要求1-9中任一项所述的方法，其中所述神经病症是神经变性病症。
11.根据权利要求10所述的方法，其中所述神经变性病症选自肌萎缩性侧索硬化(ALS；卢伽雷氏病；运动神经元病；MND)、遗传性痉挛性截瘫(HSP)、原发性侧索硬化(PLS)、进行性肌萎缩(PMA)、进行性延髓麻痹(PBP)、假性延髓麻痹、脊髓延髓肌萎缩(SBMA)以及脊髓性肌萎缩。
12.根据权利要求1-11中任一项所述的方法，其中所述诊断或预后步骤(b)包括将来自所述受试者的所述生物样品中的所述或每种生物标志物的所述定量或定性水平与正常样品中的所述或每种相应生物标志物的定量或定性水平相比较。
13.根据权利要求12所述的方法，其中来自所述受试者的所述生物样品中所述或每种生物标志物的定量或定性水平大于正常样品中的所述或每种相应生物标志物的定量或定性水平指示所述神经病症的定量或定性存在。
14.根据权利要求1-13中任一项所述的方法，其中所述生物样品选自全血、血清、血浆、尿液、间质液、腹膜液、宫颈拭子、泪液、唾液、颊面拭子、皮肤、脑组织和脑脊液。
15.根据权利要求1-14中任一项所述的方法，其中所述生物样品是全血。
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EP3788379B1 (en) 2022-06-22
WO2019211343A1 (en) 2019-11-07
JP2024009871A (ja) 2024-01-23
ES2928793T3 (es) 2022-11-22
EP3788379A1 (en) 2021-03-10
JP2021521876A (ja) 2021-08-30

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