CN112714934A - 细胞选择的多变量方法 - Google Patents
细胞选择的多变量方法 Download PDFInfo
- Publication number
- CN112714934A CN112714934A CN201980061150.4A CN201980061150A CN112714934A CN 112714934 A CN112714934 A CN 112714934A CN 201980061150 A CN201980061150 A CN 201980061150A CN 112714934 A CN112714934 A CN 112714934A
- Authority
- CN
- China
- Prior art keywords
- data
- candidate
- cells
- target
- multivariate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract description 383
- 230000008569 process Effects 0.000 claims abstract description 311
- 238000012913 prioritisation Methods 0.000 claims abstract description 76
- 238000011156 evaluation Methods 0.000 claims abstract description 46
- 238000004886 process control Methods 0.000 claims abstract description 32
- 238000004590 computer program Methods 0.000 claims abstract description 8
- 150000004676 glycans Chemical class 0.000 claims description 25
- 230000003321 amplification Effects 0.000 claims description 22
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 22
- 239000012530 fluid Substances 0.000 claims description 21
- 230000007246 mechanism Effects 0.000 claims description 11
- 230000007717 exclusion Effects 0.000 claims description 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 7
- 229910052760 oxygen Inorganic materials 0.000 claims description 7
- 239000001301 oxygen Substances 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 238000010238 partial least squares regression Methods 0.000 claims description 6
- 230000002503 metabolic effect Effects 0.000 claims description 3
- 238000011161 development Methods 0.000 claims description 2
- 239000007789 gas Substances 0.000 claims description 2
- 230000001502 supplementing effect Effects 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000006870 function Effects 0.000 description 72
- 238000005259 measurement Methods 0.000 description 38
- 239000000047 product Substances 0.000 description 27
- 230000000875 corresponding effect Effects 0.000 description 20
- 238000004458 analytical method Methods 0.000 description 17
- 230000003833 cell viability Effects 0.000 description 12
- 238000010946 mechanistic model Methods 0.000 description 11
- 238000000513 principal component analysis Methods 0.000 description 11
- 230000002596 correlated effect Effects 0.000 description 10
- 230000035899 viability Effects 0.000 description 10
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 8
- 239000008103 glucose Substances 0.000 description 8
- 238000009499 grossing Methods 0.000 description 8
- 239000013598 vector Substances 0.000 description 8
- 238000004364 calculation method Methods 0.000 description 7
- 238000007796 conventional method Methods 0.000 description 7
- 230000012010 growth Effects 0.000 description 7
- 238000012545 processing Methods 0.000 description 7
- 230000003595 spectral effect Effects 0.000 description 7
- 239000000523 sample Substances 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 5
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 5
- 239000012467 final product Substances 0.000 description 5
- 238000012544 monitoring process Methods 0.000 description 5
- 230000010261 cell growth Effects 0.000 description 4
- 238000012258 culturing Methods 0.000 description 4
- 238000011049 filling Methods 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 239000002207 metabolite Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 230000006399 behavior Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000011065 in-situ storage Methods 0.000 description 3
- 238000012886 linear function Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 238000007619 statistical method Methods 0.000 description 3
- 238000003026 viability measurement method Methods 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 229960000074 biopharmaceutical Drugs 0.000 description 2
- 238000010367 cloning Methods 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 238000010219 correlation analysis Methods 0.000 description 2
- 238000013079 data visualisation Methods 0.000 description 2
- 238000001739 density measurement Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000011066 ex-situ storage Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 238000000491 multivariate analysis Methods 0.000 description 2
- 230000001151 other effect Effects 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 238000004513 sizing Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 239000002028 Biomass Substances 0.000 description 1
- 238000003070 Statistical process control Methods 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004931 aggregating effect Effects 0.000 description 1
- 238000012098 association analyses Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000003181 biological factor Substances 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000009529 body temperature measurement Methods 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000012930 cell culture fluid Substances 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000013377 clone selection method Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 238000003066 decision tree Methods 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 231100000584 environmental toxicity Toxicity 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000012625 in-situ measurement Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000013627 low molecular weight specie Substances 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000012887 quadratic function Methods 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000004704 ultra performance liquid chromatography Methods 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B13/00—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion
- G05B13/02—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
- G05B13/04—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators
- G05B13/048—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators using a predictor
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Evolutionary Computation (AREA)
- Artificial Intelligence (AREA)
- Software Systems (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Biophysics (AREA)
- Evolutionary Biology (AREA)
- Databases & Information Systems (AREA)
- Data Mining & Analysis (AREA)
- Public Health (AREA)
- Bioethics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Automation & Control Theory (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
Abstract
Description
Claims (16)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18200386.3 | 2018-10-15 | ||
EP18200386.3A EP3640946A1 (en) | 2018-10-15 | 2018-10-15 | Multivariate approach for biological cell selection |
PCT/EP2019/077040 WO2020078747A1 (en) | 2018-10-15 | 2019-10-07 | Multivariate approach for cell selection |
Publications (2)
Publication Number | Publication Date |
---|---|
CN112714934A true CN112714934A (zh) | 2021-04-27 |
CN112714934B CN112714934B (zh) | 2024-05-10 |
Family
ID=64082855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201980061150.4A Active CN112714934B (zh) | 2018-10-15 | 2019-10-07 | 细胞选择的多变量方法 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20210383893A1 (zh) |
EP (1) | EP3640946A1 (zh) |
CN (1) | CN112714934B (zh) |
WO (1) | WO2020078747A1 (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3111046A1 (fr) * | 2020-05-29 | 2021-12-03 | Orange | Regroupement de trajectoires dans le domaine chiffré |
MX2023003352A (es) * | 2020-09-24 | 2023-03-29 | Amgen Inc | Metodos y sistemas para determinar un numero minimo de clones de lineas celulares necesarios para producir un producto que tenga un conjunto de atributos del producto diana. |
US11754536B2 (en) | 2021-11-01 | 2023-09-12 | Matterworks Inc | Methods and compositions for analyte quantification |
US20240112750A1 (en) * | 2022-10-04 | 2024-04-04 | BioCurie Inc. | Data-driven process development and manufacturing of biopharmaceuticals |
Citations (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030109998A1 (en) * | 2001-08-03 | 2003-06-12 | Lorenz Alexander D. | Automatic process for sample selection during multivariate calibration |
AU2003220998A1 (en) * | 2002-04-04 | 2003-10-20 | Ishihara Sangyo Kaisha, Ltd. | Apparatus and method for analyzing data |
US6673532B2 (en) * | 2000-08-14 | 2004-01-06 | University Of Maryland, Baltimore County | Bioreactor and bioprocessing technique |
US20040153249A1 (en) * | 2002-08-06 | 2004-08-05 | The Johns Hopkins University | System, software and methods for biomarker identification |
US6973389B1 (en) * | 1999-09-03 | 2005-12-06 | Mountassir M Hammed | Method of optimizing parameter values in a process of producing a product |
WO2007018868A1 (en) * | 2005-07-25 | 2007-02-15 | Biogen Idec Ma Inc. | System and method for bioprocess control |
US20070100475A1 (en) * | 2005-10-25 | 2007-05-03 | Korchinski William J | Method and apparatus for applying reduced nonlinear models to optimization of an operation |
US20080133044A1 (en) * | 2004-08-23 | 2008-06-05 | Herbert Grieb | Method and Arrangement For the Online Regulation of a Batch Process in a Bioreactor |
US20100191361A1 (en) * | 2009-01-23 | 2010-07-29 | Mks Instruments, Inc. | Controlling a Manufacturing Process with a Multivariate Model |
EP2270129A2 (en) * | 2009-07-01 | 2011-01-05 | The Automation Partnership (Cambridge) Limited | Bioreactor systems and associated methods of processing bioreactor vessels |
US8065089B1 (en) * | 2004-03-30 | 2011-11-22 | University Of North Carolina At Charlotte | Methods and systems for analysis of dynamic biological pathways |
CN102509243A (zh) * | 2011-09-20 | 2012-06-20 | 河北中烟工业有限责任公司 | 卷烟制造过程质量评价方法及其系统 |
CN103189744A (zh) * | 2010-10-27 | 2013-07-03 | 英国龙沙生物医药股份有限公司 | 用于靶向细胞(系)选择的快速方法 |
US20130268238A1 (en) * | 2012-04-06 | 2013-10-10 | Mks Instruments, Inc. | Multivariate Monitoring of a Batch Manufacturing Process |
US20140136146A1 (en) * | 2012-04-06 | 2014-05-15 | Mks Instruments, Inc. | Multivariate prediction of a batch manufacturing process |
CN104598774A (zh) * | 2015-02-04 | 2015-05-06 | 河南师范大学 | 基于logistic与相关信息熵的特征基因选择方法 |
US20150286778A1 (en) * | 2012-12-20 | 2015-10-08 | Roche Diabetes Care, Inc. | Methods of Evaluating Medical Measurement Curves, as Well as Computer Programs and Devices Therefor |
CN105407819A (zh) * | 2013-02-28 | 2016-03-16 | 普罗吉涅股份有限公司 | 用于自动化非侵入细胞活性追踪的设备、方法和系统 |
CN105765586A (zh) * | 2013-09-27 | 2016-07-13 | 瓦里安医疗系统国际股份公司 | 用于选择治疗计划的决定支持工具 |
CN106471508A (zh) * | 2014-06-20 | 2017-03-01 | 康涅狄格儿童医疗中心 | 自动化细胞培养系统及对应的方法 |
CN107111874A (zh) * | 2014-12-30 | 2017-08-29 | 文塔纳医疗系统公司 | 用于免疫分数计算中的共表达分析的系统和方法 |
WO2017174580A1 (en) * | 2016-04-04 | 2017-10-12 | Boehringer Ingelheim Rcv Gmbh & Co Kg | Real time monitoring of product purification |
CN107430588A (zh) * | 2015-01-22 | 2017-12-01 | 斯坦福大学托管董事会 | 用于确定不同细胞亚群的比例的方法和系统 |
US20170355947A9 (en) * | 2014-07-02 | 2017-12-14 | Biogen Ma Inc. | Cross-scale modeling of bioreactor cultures using raman spectroscopy |
CN107636141A (zh) * | 2015-07-06 | 2018-01-26 | 赛多利斯司特蒂姆生物工艺公司 | 用于测量包含在容器中的流体的多个状态参数的方法 |
US10013654B1 (en) * | 2017-11-29 | 2018-07-03 | OJO Labs, Inc. | Cooperatively operating a network of supervised learning processors to concurrently distribute supervised learning processor training and provide predictive responses to input data |
CN108490782A (zh) * | 2018-04-08 | 2018-09-04 | 中南大学 | 一种基于选择性双层集成学习适用于复杂工业过程产品质量指标缺失数据补全的方法及系统 |
-
2018
- 2018-10-15 EP EP18200386.3A patent/EP3640946A1/en active Pending
-
2019
- 2019-10-07 US US17/285,459 patent/US20210383893A1/en active Pending
- 2019-10-07 WO PCT/EP2019/077040 patent/WO2020078747A1/en active Application Filing
- 2019-10-07 CN CN201980061150.4A patent/CN112714934B/zh active Active
Patent Citations (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6973389B1 (en) * | 1999-09-03 | 2005-12-06 | Mountassir M Hammed | Method of optimizing parameter values in a process of producing a product |
US6673532B2 (en) * | 2000-08-14 | 2004-01-06 | University Of Maryland, Baltimore County | Bioreactor and bioprocessing technique |
US20030109998A1 (en) * | 2001-08-03 | 2003-06-12 | Lorenz Alexander D. | Automatic process for sample selection during multivariate calibration |
AU2003220998A1 (en) * | 2002-04-04 | 2003-10-20 | Ishihara Sangyo Kaisha, Ltd. | Apparatus and method for analyzing data |
US20040153249A1 (en) * | 2002-08-06 | 2004-08-05 | The Johns Hopkins University | System, software and methods for biomarker identification |
US8065089B1 (en) * | 2004-03-30 | 2011-11-22 | University Of North Carolina At Charlotte | Methods and systems for analysis of dynamic biological pathways |
US20080133044A1 (en) * | 2004-08-23 | 2008-06-05 | Herbert Grieb | Method and Arrangement For the Online Regulation of a Batch Process in a Bioreactor |
WO2007018868A1 (en) * | 2005-07-25 | 2007-02-15 | Biogen Idec Ma Inc. | System and method for bioprocess control |
US20070100475A1 (en) * | 2005-10-25 | 2007-05-03 | Korchinski William J | Method and apparatus for applying reduced nonlinear models to optimization of an operation |
US20100191361A1 (en) * | 2009-01-23 | 2010-07-29 | Mks Instruments, Inc. | Controlling a Manufacturing Process with a Multivariate Model |
EP2270129A2 (en) * | 2009-07-01 | 2011-01-05 | The Automation Partnership (Cambridge) Limited | Bioreactor systems and associated methods of processing bioreactor vessels |
CN103189744A (zh) * | 2010-10-27 | 2013-07-03 | 英国龙沙生物医药股份有限公司 | 用于靶向细胞(系)选择的快速方法 |
CN102509243A (zh) * | 2011-09-20 | 2012-06-20 | 河北中烟工业有限责任公司 | 卷烟制造过程质量评价方法及其系统 |
US20130268238A1 (en) * | 2012-04-06 | 2013-10-10 | Mks Instruments, Inc. | Multivariate Monitoring of a Batch Manufacturing Process |
US20140136146A1 (en) * | 2012-04-06 | 2014-05-15 | Mks Instruments, Inc. | Multivariate prediction of a batch manufacturing process |
US20150286778A1 (en) * | 2012-12-20 | 2015-10-08 | Roche Diabetes Care, Inc. | Methods of Evaluating Medical Measurement Curves, as Well as Computer Programs and Devices Therefor |
CN105407819A (zh) * | 2013-02-28 | 2016-03-16 | 普罗吉涅股份有限公司 | 用于自动化非侵入细胞活性追踪的设备、方法和系统 |
CN105765586A (zh) * | 2013-09-27 | 2016-07-13 | 瓦里安医疗系统国际股份公司 | 用于选择治疗计划的决定支持工具 |
CN106471508A (zh) * | 2014-06-20 | 2017-03-01 | 康涅狄格儿童医疗中心 | 自动化细胞培养系统及对应的方法 |
US20170355947A9 (en) * | 2014-07-02 | 2017-12-14 | Biogen Ma Inc. | Cross-scale modeling of bioreactor cultures using raman spectroscopy |
CN107111874A (zh) * | 2014-12-30 | 2017-08-29 | 文塔纳医疗系统公司 | 用于免疫分数计算中的共表达分析的系统和方法 |
CN107430588A (zh) * | 2015-01-22 | 2017-12-01 | 斯坦福大学托管董事会 | 用于确定不同细胞亚群的比例的方法和系统 |
CN104598774A (zh) * | 2015-02-04 | 2015-05-06 | 河南师范大学 | 基于logistic与相关信息熵的特征基因选择方法 |
CN107636141A (zh) * | 2015-07-06 | 2018-01-26 | 赛多利斯司特蒂姆生物工艺公司 | 用于测量包含在容器中的流体的多个状态参数的方法 |
WO2017174580A1 (en) * | 2016-04-04 | 2017-10-12 | Boehringer Ingelheim Rcv Gmbh & Co Kg | Real time monitoring of product purification |
US10013654B1 (en) * | 2017-11-29 | 2018-07-03 | OJO Labs, Inc. | Cooperatively operating a network of supervised learning processors to concurrently distribute supervised learning processor training and provide predictive responses to input data |
CN108490782A (zh) * | 2018-04-08 | 2018-09-04 | 中南大学 | 一种基于选择性双层集成学习适用于复杂工业过程产品质量指标缺失数据补全的方法及系统 |
Non-Patent Citations (1)
Title |
---|
武海滨;张涛;赵发林;李康;: "基于偏最小二乘线性判别分析的遗传算法在代谢组学特征筛选中的应用", 中国卫生统计, vol. 30, no. 04, pages 517 - 520 * |
Also Published As
Publication number | Publication date |
---|---|
US20210383893A1 (en) | 2021-12-09 |
EP3640946A1 (en) | 2020-04-22 |
CN112714934B (zh) | 2024-05-10 |
WO2020078747A1 (en) | 2020-04-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN112714934B (zh) | 细胞选择的多变量方法 | |
JP7092879B2 (ja) | 細胞培養物の代謝状態の予測 | |
US20220228102A1 (en) | Data-driven predictive modeling for cell line selection in biopharmaceutical production | |
US20200202051A1 (en) | Method for Predicting Outcome of an Modelling of a Process in a Bioreactor | |
US11542564B2 (en) | Computer-implemented method, computer program product and hybrid system for cell metabolism state observer | |
EP3291038B1 (en) | Controlling and monitoring a process to produce a chemical, pharmaceutical or biotechnological product | |
Wechselberger et al. | PAT method to gather bioprocess parameters in real-time using simple input variables and first principle relationships | |
CN111201434A (zh) | 用于控制细胞培养物中的过程变量的原位拉曼光谱系统和方法 | |
CN111615674B (zh) | 缩放工具 | |
AU2020330701B2 (en) | Method for determining process variables in cell cultivation processes | |
US20220146987A1 (en) | Multivariate process chart to control a process to produce a chemical, pharmaceutical, biopharmaceutical and/or biological product | |
WO2023167802A1 (en) | Hybrid predictive modeling for control of cell culture | |
US20220137579A1 (en) | Optimized process control | |
JP7153131B2 (ja) | 培養装置の性能を検証する方法 | |
Fernandes et al. | Extended and Unscented Kalman Filter design for hybridoma cell fed-batch and continuous cultures. | |
US20230002708A1 (en) | Adapting control of a cell culture in a production scale vessel with regard to a starting medium | |
US11977090B2 (en) | Walk-away time visualization methods and systems | |
Herold | Automatic generation of process models for fed-batch fermentations based on the detection of biological phenomena | |
Munack | Measurement, modelling and control problems for biotechnical processes |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: New leaf. Yu rose Inventor after: Ernst Coney westrand Inventor after: Nils Eric Stefan lanar Inventor after: Christopher zehe Inventor after: Eric Axel Johnson Inventor after: Christopher Peter mcrandy Inventor before: Yu rose. Xinye Inventor before: Ernst Coney westrand Inventor before: Nils Eric Stefan lanar Inventor before: Christopher zehe Inventor before: Eric Axel Johnson Inventor before: Christopher Peter mcrandy |
|
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |