CN112714646A - 蛋白酪氨酸激酶6(ptk6)降解/破坏化合物和使用方法 - Google Patents

蛋白酪氨酸激酶6(ptk6)降解/破坏化合物和使用方法 Download PDF

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CN112714646A
CN112714646A CN201980058356.1A CN201980058356A CN112714646A CN 112714646 A CN112714646 A CN 112714646A CN 201980058356 A CN201980058356 A CN 201980058356A CN 112714646 A CN112714646 A CN 112714646A
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alkyl
membered
heterocyclyl
heteroaryl
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金剑
H·艾瑞斯
刘静
熊燕
J·拜尔里
S·托米塔
J·P·胡
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Icahn School of Medicine at Mount Sinai
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980058356.1A 2018-07-05 2019-07-03 蛋白酪氨酸激酶6(ptk6)降解/破坏化合物和使用方法 Pending CN112714646A (zh)

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US201862694118P 2018-07-05 2018-07-05
US62/694,118 2018-07-05
PCT/US2019/040507 WO2020010204A1 (en) 2018-07-05 2019-07-03 Protein tyrosine kinase 6 (ptk6) degradation / disruption compounds and methods of use

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EP (1) EP3817745A4 (enExample)
JP (1) JP2021529807A (enExample)
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CA (1) CA3105121A1 (enExample)
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Cited By (3)

* Cited by examiner, † Cited by third party
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CN113354619A (zh) * 2021-06-24 2021-09-07 皖南医学院 一种靶向泛素化降解酪氨酸酶的化合物及其制备方法和应用
CN113956233A (zh) * 2021-10-22 2022-01-21 南方医科大学 一种酰胺类化合物或其药学上可接受的盐及其制备方法和应用
CN121800878A (zh) * 2025-12-30 2026-04-07 上海核舟医药有限公司 Ptk7靶向药物及其制备方法和应用

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JP2021527666A (ja) 2018-06-21 2021-10-14 アイカーン スクール オブ メディスン アット マウント シナイ Ｗｄ４０反復ドメインタンパク質５（ｗｄｒ５）分解／破壊化合物および使用の方法
CN114423463B (zh) 2019-05-06 2025-09-26 西奈山伊坎医学院 作为hpk1的降解剂的异双功能化合物
US12103924B2 (en) 2020-06-01 2024-10-01 Icahn School Of Medicine At Mount Sinai Mitogen-activated protein kinase kinase (MEK) degradation compounds and methods of use
KR20240132352A (ko) * 2022-01-07 2024-09-03 다나-파버 캔서 인스티튜트 인크. Swi/snf 관련, 매트릭스 연관, 염색질의 액틴 의존성 조절 인자, 서브패밀리 a, 멤버 4(smarca4)의 표적화

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CN113354619A (zh) * 2021-06-24 2021-09-07 皖南医学院 一种靶向泛素化降解酪氨酸酶的化合物及其制备方法和应用
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CN121800878A (zh) * 2025-12-30 2026-04-07 上海核舟医药有限公司 Ptk7靶向药物及其制备方法和应用

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JP2021529807A (ja) 2021-11-04
CA3105121A1 (en) 2020-01-09
US12678507B2 (en) 2026-07-14
US20230070613A1 (en) 2023-03-09
EP3817745A1 (en) 2021-05-12
EP3817745A4 (en) 2022-04-06
WO2020010204A1 (en) 2020-01-09

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