CN112704640A - Multifunctional traditional Chinese medicine oral liquid refining combination system - Google Patents
Multifunctional traditional Chinese medicine oral liquid refining combination system Download PDFInfo
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Images
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
- B01D35/02—Filters adapted for location in special places, e.g. pipe-lines, pumps, stop-cocks
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/80—After-treatment of the mixture
- B01F23/808—Filtering the mixture
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
- B01F33/811—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles in two or more consecutive, i.e. successive, mixing receptacles or being consecutively arranged
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/181—Preventing generation of dust or dirt; Sieves; Filters
- B01F35/187—Preventing generation of dust or dirt; Sieves; Filters using filters in mixers, e.g. during venting
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/90—Heating or cooling systems
- B01F35/92—Heating or cooling systems for heating the outside of the receptacle, e.g. heated jackets or burners
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D11/00—Self-contained movable devices, e.g. domestic refrigerators
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D23/00—General constructional features
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D23/00—General constructional features
- F25D23/006—General constructional features for mounting refrigerating machinery components
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2200/00—General characteristics or adaptations
- A61J2200/40—Heating or cooling means; Combinations thereof
- A61J2200/42—Heating means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2200/00—General characteristics or adaptations
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- A—HUMAN NECESSITIES
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- A61J2200/00—General characteristics or adaptations
- A61J2200/70—Device provided with specific sensor or indicating means
- A61J2200/72—Device provided with specific sensor or indicating means for temperature
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B—PERFORMING OPERATIONS; TRANSPORTING
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Abstract
The invention relates to a multifunctional traditional Chinese medicine oral liquid refining combination system, which is suitable for traditional Chinese medicine oral liquid refining and preparation forming and belongs to the field of traditional Chinese medicine pharmaceutical equipment. Mainly by medicine boiling tank (1), filter (2), cold-stored jar (3) are constituteed, and its characterized in that, medicine boiling tank (1) keeps dismantling through first conveying pipeline (4) and filter (2) and is connected, and simultaneously, cold-stored jar (3) keep dismantling through second conveying pipeline (5) and filter (2) and be connected, and the three forms medicine boiling tank-filter-cold-stored jar combined system. The invention has novel design, reasonable structure, convenient operation and accurate control, can continuously operate the whole processes of medicine boiling, filtering and cold storage, reduces the loss of liquid medicine, reduces energy consumption, saves time and has high efficiency, can prevent the loss and the change of photosensitive components, thermosensitive components and volatile components, and improves the stability and the controllability of the preparation.
Description
Technical Field
The invention relates to a multifunctional traditional Chinese medicine oral liquid refining combination system, which is suitable for a traditional Chinese medicine oral liquid preparation forming and refining process and belongs to the field of traditional Chinese medicine pharmaceutical equipment.
Background
The traditional Chinese medicine oral liquid preparation has complex components, and most of the traditional Chinese medicine oral liquid preparation has the problem of precipitation after long-term storage. Research shows that most of the precipitated precipitates are polysaccharide, protein and tannin components, and may also be alkaloids and glycosides with poor water solubility. The general method for solving the above problems is: boiling the prepared solution, refrigerating for a certain time, filtering, preparing the obtained filtrate, filling, and sterilizing to obtain the final product of oral liquid.
The purpose of decocting the oral liquid extract is to dissolve or form colloid of macromolecular substances with poor water solubility in the liquid medicine as much as possible through thermal reaction, so that the macromolecular substances exist in the liquid medicine in a more stable state. And then the components which are still insoluble in the liquid medicine under the condition form precipitates by prolonging the refrigeration time, and then the precipitates are removed in a filtering way, thereby achieving the purposes of stable properties of the liquid medicine and no precipitation after long-term storage. However, different Chinese medicine varieties require different medicine boiling process parameters, such as medicine boiling temperature, liquid medicine volume, filtering mode, cold storage temperature, whether an adsorbent is added or not, whether hot filtration is required or not, and the like. The precipitation states in the prepared solution are different, the sediment with high viscosity is easy to block the filter plate, the filtering difficulty is increased, and the sediment which is too fine is easy to pass through the filter holes, so that the filtering efficiency is reduced. Aiming at the common technical problems of different oral liquid varieties, a targeted technical scheme is required to meet the requirement of large-scale production.
According to the prior art, the equipment used by traditional Chinese medicine manufacturers is generally a medicine boiling tank, a refrigeration tank and a plate-and-frame filter. The medicine boiling pot is a pressure device with a fixed volume and is provided with an interlayer which can be heated by steam; the storage tank is heat preservation equipment with a fixed volume and an interlayer which can be communicated with a refrigerant; the plate frame filter is a filter device which can be matched with fast filter paper or slow filter paper. The three devices are usually connected by a hose or a stainless steel pipe when in use, and the connection effect depends on the experience and the concentration of an operator. In the process of forming or refining the traditional Chinese medicine liquid oral liquid preparation, the operation of the traditional Chinese medicine liquid oral liquid preparation needs more than two persons to complete in a matching way, the equipment has no protective measures, and when an accident happens in the operation process, if the liquid medicine is sprayed due to blockage, an operator cannot obtain effective protection. Under the condition of the existing equipment, the operations of medicine boiling, filtering and refrigeration are inconvenient, the labor intensity is high, the field dirt is more, the secondary pollution of the production environment is easily caused, and the requirements of cGMP production of the existing medicines are not met.
In addition, some traditional Chinese medicine varieties contain photosensitive components, thermosensitive components or volatile components, the loss of the thermosensitive components and the volatile components can be caused when the traditional medicine boiling pot is used for heating, so that the medicine quality is influenced, and the risk of component oxidation or decomposition caused by the fact that liquid medicine contacts air or light exists when the traditional plate-and-frame filter is used.
Disclosure of Invention
Aiming at the common technical problems that the existing medicine boiling, filtering or refrigerating process is easy to cause the volatilization and loss of components containing light sensitivity, heat sensitivity or easy volatilization and easy oxidation, and the forming process of the traditional Chinese medicine oral liquid preparation has inconvenient operation, high labor intensity, more field dirt, easy secondary pollution to the production environment, no compliance with the requirements of the existing medicine production cGMP and the like, the invention aims to provide a multifunctional traditional Chinese medicine oral liquid refining combination system.
The inventor keeps detachably connecting the medicine boiling tank, the cold storage tank and the filter through the conveying pipeline on the basis of the traditional medicine boiling tank, the filter and the cold storage tank, the medicine boiling tank, the filter and the cold storage tank form a combined system of the medicine boiling tank, the filter and the cold storage tank, the continuous operation of operations such as medicine boiling, filtering, cold storage and the like is realized, the loss of liquid medicine is reduced, the energy consumption is reduced, the time and the efficiency are saved, the loss and the change of photosensitive components, thermosensitive components and volatile components can be prevented, and the stability and the controllability of the preparation are improved. In addition, the inventor realizes the interchange and the replacement of the cold storage tank and the medicine boiling tank by technically transforming the interlayer of the medicine boiling tank and the cold storage tank, and greatly increases the capacity of the traditional Chinese medicine oral liquid refining system under the condition of not increasing the investment of equipment.
The technical problem solved by the invention is realized by the following technical scheme:
a multifunctional traditional Chinese medicine oral liquid refining combination system mainly comprises a medicine boiling tank 1, a filter 2 and a refrigerating tank 3, and is characterized in that: medicine boiling tank 1 keeps dismantling through first conveying pipeline 4 and filter 2 and is connected, and simultaneously, cold-stored jar 3 keeps dismantling to be connected through second conveying pipeline 5 and filter 2, and the three forms medicine boiling tank-filter-cold-stored jar combined system.
The utility model discloses a boiling pot, including boiling pot 1, jar body top middle part is provided with first condenser 6, and jar body top left side is equipped with first compressed nitrogen gas air inlet 7, and jar body top right side is equipped with first feed inlet 8, and jar body intermediate layer is equipped with first steam heating valve 9 and first refrigerant cooling valve 10 simultaneously, and jar internal side wall has first temperature detector 11, and jar internal bottom has first stirring rake 12, and first conveying pipeline 4 is by valve control.
The central authorities of the top of the tank body of the cold storage tank 3 are provided with a second condenser 13, the left side of the top of the tank body is provided with a second compressed nitrogen inlet 15, the right side of the top of the tank body is provided with a second feed inlet 14, the interlayer of the tank body is simultaneously provided with a second steam heating valve 16 and a second refrigerant cooling valve 17, the inner side wall of the tank body is provided with a second temperature detector 18, the bottom in the tank body is provided with a second stirring paddle 19, and a second feed delivery pipe 5 is controlled by a valve.
In the invention, two ends of a filter 2 are provided with first detachable stainless steel sealing partition plates 20, and a first detachable stainless steel filtering clamping groove 21 is arranged inside the filter; the first detachable stainless steel sealing partition plate 20 of the filter 2 is a stainless steel circular plate with the thickness of 3-5cm, and the first detachable stainless steel filtering clamping groove 21 is a stainless steel circular ring with the thickness of 3-5 cm.
The right side of the bottom of the tank body of the refrigerating tank 3 is provided with a discharging device 22 with a filtering function, the two ends of the discharging device are provided with a second detachable stainless steel sealing partition plate 23, the inside of the discharging device is provided with a second detachable stainless steel filtering clamping groove 24, and the second detachable stainless steel filtering clamping groove 24 is connected with an electric pump 25.
In the invention, the interiors of the first condenser 6 and the second condenser 13 are formed by surrounding hollow cylindrical pipelines by spiral coils, the top ends of the first condenser 6 and the second condenser 13 are respectively provided with an exhaust port, and cooling water with the temperature of 4-15 ℃ is introduced into the spiral coils; the optimum temperature of the cooling water is 4 ℃.
The first compressed nitrogen inlet 7 is composed of an opening with a downward opening end and a 90-degree included angle with the medicine boiling pot 1, and the second compressed nitrogen inlet 15 is composed of an opening with a downward opening end and a 90-degree included angle with the medicine boiling pot 3.
A steam inlet of the first steam heating valve 9 is positioned at the lower end of the left side of the medicine boiling pot 1, and a steam outlet of the first steam heating valve 9 is positioned at the upper end of the right side of the medicine boiling pot 1; the steam inlet of the second steam heating valve 16 is positioned at the lower left end of the refrigerating tank 3, and the steam outlet of the second steam heating valve 16 is positioned at the upper right end of the refrigerating tank 3.
A refrigerant inlet of the first refrigerant cooling valve 10 is positioned at the lower end of the right side of the medicine boiling tank 1, and a refrigerant outlet of the first refrigerant cooling valve 10 is positioned at the upper end of the left side of the tank body 1; the refrigerant inlet of the second refrigerant cooling valve 16 is located at the lower end of the right side of the tank 3, and the refrigerant outlet is located at the upper end of the left side of the tank 3.
In the design and improvement process of the multifunctional traditional Chinese medicine oral liquid refining combination system, the inventor notices that certain liquid medicine contains volatile components, and when the traditional Chinese medicine decocting pot is used for decocting, the volatile components are volatilized due to the rise of temperature, so that the loss of the volatile components is caused, and the quality of a final product is further influenced. Therefore, the first condenser 6 and the second condenser 13 are respectively arranged above the medicine boiling tank 1 and the refrigerating tank 3, in the heating process of the liquid medicine, water can be evaporated and rise to the upper part of the tank body, volatile components in the liquid medicine can rise along with water vapor, the water vapor containing the volatile components can be condensed again when meeting the condenser in the rising process and fall back to the liquid medicine in the tank, and the purpose of protecting the volatile components in the liquid medicine from being lost due to heating is achieved.
Some traditional Chinese medicine liquid contains heat-sensitive components, and the heat-sensitive components can be decomposed or converted into other substances when the heating temperature is too high. Therefore, the first temperature detector 11 and the second temperature detector 18 are arranged in the third part of the distance between the bottoms of the medicine boiling tank 1 and the refrigerating tank 3 so as to detect the temperature of the liquid medicine in time, and when the liquid medicine in the tanks reaches the set temperature, an alarm can be given out to prompt so as to realize accurate temperature control, avoid the loss of the liquid medicine caused by the damage of partial heat-sensitive components due to overhigh heating temperature and avoid the problem that the ideal medicine boiling effect cannot be achieved due to overlow heating temperature.
The invention also designs a filtering system taking compressed nitrogen as power aiming at the medicine containing photosensitive components and easily-oxidized components, so that the liquid medicine does not contact air and natural light in the whole process of medicine boiling, cold storage and filtering, and related components in the liquid medicine are protected from being damaged.
In addition, different medical liquids have different fluidity and permeability due to different components, the medical liquid with high viscosity is relatively difficult to filter, the medical liquid with low viscosity has relatively high filtering speed, and the filtering medium has great influence on the filtering speed. Through research, the inventor innovatively designs the filter 2 into a cylindrical structure with first detachable stainless steel sealing partition plates 20 at two ends and 5-10 layers of first detachable stainless steel filtering clamping grooves 21 in the middle, can select the quantity of the clamping grooves according to filtering requirements, and can close the filtering partition plates at any time in the filtering process to replace filtering media. Specifically, the first detachable stainless steel sealing partition plate 20 is a stainless steel circular plate with the thickness of 3-5cm, and the first detachable stainless steel filtering clamping groove 21 is a stainless steel circular ring with the thickness of 3-5 cm. The filter screen can be inlayed according to the filtration demand to the inboard, does to cut filter paper to corresponding size, and it is fixed to filter the buckle on the draw-in groove 21 through first detachable stainless steel. When the liquid medicine needs to be filtered, two ends of the filter 2 are respectively connected with the first conveying pipe 4 and the second conveying pipe 5, then a required filter screen or filter paper is installed in the first detachable stainless steel filtering clamping groove 21, after the connection is confirmed to be correct and the connection is sealed perfectly, the valve connecting the first conveying pipe 4 and the second conveying pipe 5 is opened, the valve of the first compressed nitrogen gas inlet 7 at the top end of the medicine boiling tank 1 is opened, and the liquid medicine can be filtered from the medicine boiling tank 1 to the cold storage tank 3; when the liquid medicine does not need to be filtered, the filter 2 can be used as a communication pipe without installing a filter medium.
Specifically, during the drug boiling, filtering and refrigerating operations, the valves of the first delivery pipe 4 and the second delivery pipe 5 are firstly ensured to be closed, then the drug liquid is continuously introduced into the drug boiling tank 1 from the first feed port 8, and the first steam heating valve 9, the first condenser 6 at the top of the tank body and the first stirring paddle 12 are opened for stirring and heating. After the liquid medicine heats to the uniform temperature and keeps warm for a period of time, put required filtering material into the first stainless steel filter slot 21 of dismantling of filter 2, and with the draw-in groove installation fixed, after guaranteeing that the system is sealed, open the valve of first conveying pipeline 4 and second conveying pipeline 2, and open the first stainless steel seal baffle 20 of dismantling at filter 2 both ends, open the valve of the first compression nitrogen gas inlet 7 at boiling pot 1 top simultaneously, make the liquid medicine filter through filter 2 with the help of the pressure difference of boiling pot 1 and cold-stored jar 3, and go into cold-stored jar 3 and refrigerate.
After the liquid medicine in the medicine boiling tank 1 completely enters the refrigerating tank 3, the first detachable stainless steel sealing partition plate 20 of the filter 2 is closed, the valves of the first conveying pipe 4 and the second conveying pipe 5 are closed, the second refrigerant cooling valve 17 of the refrigerating tank 3 is opened, the liquid medicine is cooled to a certain temperature, and the liquid medicine is refrigerated in a sealed mode. After the liquid medicine is cold-stored to the regulation time, open the discharging device 22 on 3 jar body bottoms of cold-stored jar on right side, install the second and can dismantle stainless steel seal partition 23, and put into filtering material that the second can be dismantled in stainless steel filter slot 24, open the second compression nitrogen gas inlet 15 valve at 3 tops of cold-stored jar, let in nitrogen gas, open electric pump 25 simultaneously, import the liquid medicine from cold-stored jar 3 to liquid medicine filling line, realize filtering, the isolated of liquid medicine and air in the cold-stored process, easy oxidation composition is not destroyed in the protection liquid medicine.
Another application scenario of the present invention is as follows. If the capacity of the medicine boiling tank 1 is not enough to contain all the medicine liquid and the medicine liquid does not need to be filtered, the medicine boiling tank 1 and the cold storage tank 3 can be used for medicine boiling and cold storage operation at the same time, and the method specifically comprises the following steps: the first detachable stainless steel seal partition plates 20 at both ends of the filter 2 are detached, and the filter 2 is used as a communication pipe. And (3) opening valves of a first material conveying pipe 4 and a second material conveying pipe 5, keeping the medicine boiling tank 1 and the refrigerating tank 3 communicated, continuously introducing the liquid medicine into the medicine boiling tank 1 and the refrigerating tank 3 through a first feeding hole 8 and a second feeding hole 15, respectively opening a first steam heating valve 9 and a second steam heating valve 16, starting a first condenser 6 and a second condenser 13, and starting to boil the medicine. When the liquid medicine is heated to reach the specified temperature and the heat preservation is finished, the first steam heating valve 9 and the second steam heating valve 16 are closed, the first refrigerant cooling valve 10 and the second refrigerant cooling valve 17 are opened, and the refrigeration is started. After the liquid medicine is cold-stored to the regulation time, discharge device 22 that has filtering capability with the liquid medicine by 3 jar body bottoms in cold-stored jar is emitted, filter material is put into in the stainless steel filter card groove 24 can be dismantled to the second, open the valve of first compressed nitrogen gas air inlet 7 and second compressed nitrogen gas air inlet 15, let in nitrogen gas, open electric pump 25 simultaneously and prepare the production line with the corresponding liquid medicine of liquid medicine suction from decocting jar 1 and cold-stored jar 3, realize filtering, the isolated of liquid medicine and air in the cold-stored process, easily oxidation composition is not destroyed in the protection liquid medicine.
The multifunctional traditional Chinese medicine refining combined system keeps the medicine boiling tank, the cold storage tank and the filter in detachable connection through the conveying pipe, and the medicine boiling tank, the filter and the cold storage tank form the medicine boiling tank-filter-cold storage tank combined system, so that the continuity of operations such as medicine boiling, filtering, cold storage and the like is realized, the liquid medicine loss is reduced, the energy consumption is reduced, the time and the efficiency are saved, the loss and the change of photosensitive components, thermosensitive components and volatile components can be prevented, and the quality and the stability of a preparation are improved.
The invention has novel design, reasonable structure, convenient operation, accurate control, continuous operation in the whole process of medicine boiling, filtration and refrigeration, obvious technical effect and the following substantive characteristics and progresses compared with the prior conventional medicine boiling and refrigeration equipment:
1. the multifunctional traditional Chinese medicine oral liquid refining combined system utilizes the conveying pipe to carry out closed type communication transformation on the medicine boiling tank, the filter and the refrigerating tank, can realize four-in-one continuous operation of medicine boiling, filtering, refrigerating and conveying, reduces the loss of liquid medicine, and is time-saving, labor-saving, energy-saving and efficient.
2. The improved medicine boiling pot has the advantages that loss and change of photosensitive components, thermosensitive components and volatile components are greatly reduced through the nitrogen pressurizing device, the condensing device and the temperature control system, the medicine boiling pot has the advantages of being accurate in temperature control, safe and environment-friendly, and the inherent quality stability of a preparation is improved.
3. According to the invention, the conventional medicine boiling tank and the interlayer of the refrigerating tank are technically improved, so that the refrigerating tank and the medicine boiling tank are exchanged and replaced, the capacity of a traditional Chinese medicine oral liquid refining system is greatly increased under the condition of not increasing the equipment investment, the equipment utilization rate is improved, the system floor area is saved, and the equipment investment and the construction cost are reduced.
4. The combined system can realize continuous feeding, medicine boiling, filtering and refrigerating operation under the condition of full-speed operation, overcomes the defects of high labor intensity, more field dirt, easy secondary pollution of production environment and the like, reduces the production cost, is beneficial to realizing automatic production, can reduce the potential safety hazard of operators by using the closed filtering system, realizes the aim of safe and efficient production, and has wide popularization and application prospects.
Drawings
In order to facilitate understanding and mastering of the technical solution of the present invention, the drawings will be briefly described below. It should be understood that the following drawings are not to be considered limiting of the described scope of the technical solution, and that other relevant drawings can be derived from the following drawings without inventive effort for a person skilled in the art.
FIG. 1 is a structural schematic diagram of a multifunctional Chinese medicinal oral liquid refining combination system
The scores in the figures are as follows: 1-medicine boiling pot; 2-a filter; 3-a refrigeration tank; 4-a first delivery pipe; 5-a second conveying pipeline; 6-a first condenser; 7-first compressed nitrogen inlet; 8-a first feed port; 9-a first steam heating valve; 10-a first refrigerant cooling valve; 11-a first temperature probe; 12-a first paddle; 13-a second condenser; 14-a second feed port; 15-a second compressed nitrogen inlet; 16-a second steam heating valve; 17-a second refrigerant cooling valve; 18-a second temperature probe; 19-a second paddle; 20-a first removable stainless steel seal separator; 21-a first detachable stainless steel filter card slot; 22-a discharge device; 23-a second removable stainless steel seal separator; 24-a second detachable stainless steel filter card slot; 25-electric pump.
Detailed Description
The following describes in further detail embodiments of the present invention with reference to the accompanying drawings.
In order to make the objects, technical solutions and advantages of the present application clearer and clearer, the technical solutions in the embodiments will be described in detail and fully with reference to the accompanying drawings. It should be apparent that the following examples are part, but not all, of the examples of the present application. In general, the components and connections shown and described in the drawings and this embodiment may be arranged and configured in other ways, not to mention here, due to space limitations.
Therefore, the following detailed description of the embodiments does not limit the scope of the claims of the present application, and equivalents and modifications made by those skilled in the art without inventive faculty are intended to be included in the scope of the present invention.
Example 1 Structure and operation of multifunctional Chinese medicinal oral liquid refining combination System
As shown in the attached figure 1, the high-efficiency extraction centrifugal device mainly comprises a medicine boiling tank 1, a filter 2 and a cold storage tank 3, wherein the medicine boiling tank 1 is detachably connected with the filter 2 through a first material conveying pipe 4, and the cold storage tank 3 is detachably connected with the filter 2 through a second material conveying pipe 5 to form a medicine boiling tank-filter-cold storage tank combined system.
The utility model discloses a boiling pot, including boiling pot 1, jar body top middle part is provided with first condenser 6, and jar body top left side is equipped with first compressed nitrogen gas air inlet 7, and jar body top right side is equipped with first feed inlet 8, and jar body intermediate layer is equipped with first steam heating valve 9 and first refrigerant cooling valve 10 simultaneously, and jar internal side wall has first temperature detector 11, and jar internal bottom has first stirring rake 12, and first conveying pipeline 4 is by valve control.
The central authorities of the top of the tank body of the cold storage tank 3 are provided with a second condenser 13, the left side of the top of the tank body is provided with a second compressed nitrogen inlet 15, the right side of the top of the tank body is provided with a second feed inlet 14, the interlayer of the tank body is simultaneously provided with a second steam heating valve 16 and a second refrigerant cooling valve 17, the inner side wall of the tank body is provided with a second temperature detector 18, the bottom in the tank body is provided with a second stirring paddle 19, and a second feed delivery pipe 5 is controlled by a valve.
During the operations of decoction, filtration and refrigeration, the valves of the first material conveying pipe 4 and the second material conveying pipe 5 are firstly ensured to be closed, then the liquid medicine is continuously introduced into the medicine boiling tank 1 from the first material inlet 8, and the first steam heating valve 9, the first condenser 6 at the top of the tank body and the first stirring paddle 12 are opened for stirring and heating. After the liquid medicine heats to the uniform temperature and keeps warm for a period of time, put required filtering material into the first stainless steel filter slot 21 of dismantling of filter 2, and with the draw-in groove installation fixed, after guaranteeing that the system is sealed, open the valve of first conveying pipeline 4 and second conveying pipeline 2, and open the first stainless steel seal baffle 20 of dismantling at filter 2 both ends, open the valve of the first compression nitrogen gas inlet 7 at boiling pot 1 top simultaneously, make the liquid medicine filter through filter 2 with the help of the pressure difference of boiling pot 1 and cold-stored jar 3, and go into cold-stored jar 3 and refrigerate.
After the liquid medicine in the medicine boiling tank 1 completely enters the refrigerating tank 3, the first detachable stainless steel sealing partition plate 20 of the filter 2 is closed, the valves of the first conveying pipe 4 and the second conveying pipe 5 are closed, the second refrigerant cooling valve 17 of the refrigerating tank 3 is opened, the liquid medicine is cooled to a certain temperature, and the liquid medicine is refrigerated in a sealed mode. After the liquid medicine is cold-stored to the regulation time, open the discharging device 22 on 3 jar body bottoms of cold-stored jar on right side, install the second and can dismantle stainless steel seal partition 23, and put into filtering material that the second can be dismantled in stainless steel filter slot 24, open the second compression nitrogen gas inlet 15 valve at 3 tops of cold-stored jar, let in nitrogen gas, open electric pump 25 simultaneously, import the liquid medicine from cold-stored jar 3 to liquid medicine filling line, realize filtering, the isolated of liquid medicine and air in the cold-stored process, easy oxidation composition is not destroyed in the protection liquid medicine.
Example 2 mode of operation of a multifunctional Chinese medicinal oral liquid refining combination System alone as a decocting tank
Another application scenario of the invention is to use the medicine boiling tank 1 and the cold storage tank 3 to carry out medicine boiling and cold storage operations at the same time, which specifically comprises the following steps: the first detachable stainless steel seal partition plates 20 at both ends of the filter 2 are detached, and the filter 2 is used as a communicating pipe. And (3) opening valves of a first material conveying pipe 4 and a second material conveying pipe 5, keeping the medicine boiling tank 1 and the refrigerating tank 3 communicated, continuously introducing the liquid medicine into the medicine boiling tank 1 and the refrigerating tank 3 through a first feeding hole 8 and a second feeding hole 15, respectively opening a first steam heating valve 9 and a second steam heating valve 16, starting a first condenser 6 and a second condenser 13, and starting to boil the medicine. When the liquid medicine is heated to reach the specified temperature and the heat preservation is finished, the first steam heating valve 9 and the second steam heating valve 16 are closed, the first refrigerant cooling valve 10 and the second refrigerant cooling valve 17 are opened, and the refrigeration is started. After the liquid medicine is cold-stored to the regulation time, discharge device 22 that has filtering capability with the liquid medicine by 3 jar body bottoms in cold-stored jar is emitted, filter material is put into in the stainless steel filter card groove 24 can be dismantled to the second, open the valve of first compressed nitrogen gas air inlet 7 and second compressed nitrogen gas air inlet 15, let in nitrogen gas, open electric pump 25 simultaneously and prepare the production line with the corresponding liquid medicine of liquid medicine suction from decocting jar 1 and cold-stored jar 3, realize filtering, the isolated of liquid medicine and air in the cold-stored process, easily oxidation composition is not destroyed in the protection liquid medicine.
Example 3 preparation of Xintong oral liquid, decoction, filtration and refrigeration
The 'Xintong oral liquid' supply and preparation liquid of the Lunan Thick pharmaceutical Co Ltd is taken as a research object, and the influence of the parameter settings of the condenser and the temperature detector on the protection effect of the medicine components is investigated. The prescription of the 'Xintong oral liquid' is complex, the types of active ingredients are various, the Xintong oral liquid contains photosensitive ingredients, volatile ingredients and thermosensitive ingredients, and the Xintong oral liquid has good representativeness when used for medicine boiling, refrigeration and filtration investigation tests. The test method and results are as follows:
173.3kg of astragalus, 93.3kg of codonopsis pilosula, 66.7kg of radix ophiopogonis, 53.3kg of polygonum multiflorum, 53.3kg of epimedium, 146.7kg of radix puerariae, 53.3kg of angelica, 100kg of salvia miltiorrhiza, 53.3kg of spina gleditsiae, 93.3kg of seaweed, 93.3kg of kelp, 93.3kg of oyster and 26.7kg of immature bitter orange are taken, the thirteen medicinal materials, the radix puerariae and the salvia miltiorrhiza are heated and refluxed with 70 percent ethanol twice for 1 hour each time, and the ethanol extract is merged for standby; decocting the medicine residues and eleven ingredients such as astragalus mongholicus and the like with water twice, the first time lasts for 2 hours, the second time lasts for 1.5 hours, filtering is carried out, the filtrate is concentrated to the relative density of 1.15-1.25(70 ℃), the filtrate is combined with ethanol extract, a proper amount of ethanol is added to ensure that the ethanol content reaches 65%, cooling water is introduced for standing and precipitating for 24-48 hours, filtering is carried out, the ethanol is recovered from the filtrate, the filtrate is concentrated to the relative density of 1.20-1.25 (70 ℃), a proper amount of purified water is added, refrigerating and filtering are carried out, a proper amount of medicinal carbon is added, the medicine is boiled by using a medicine boiling pot 1 of the multifunctional Chinese medicine oral liquid refining combination system, filtering is carried out by using a filter 2, then heating is carried out by using a refrigerating pot 3, heat preservation and filtering are carried out, then cold precipitation is carried out for 24 hours.
TABLE 1 Effect of condensing and temperature control systems on target ingredients in Xintong oral liquids
The oral liquid for cardiac administration produced by conventional equipment and process has ferulic acid content of 0.294-0.319mg/ml, is not sensitive to light, is easy to oxidize and is easy to decompose by heating; the content of stilbene glucoside in the XINTONG oral liquid is 0.5708-0.5800 mg/mL.
As can be seen from Table 1, the contents of ferulic acid, stilbene glucoside and ligustilide in the oral liquid medicine for relieving angina pectoris gradually decrease with the increase of heating temperature, and the decrease of the cooling amplitude can be reduced by opening the condenser. Ligustilide is volatile component, and can be condensed into oil drops by condenser in volatilization process to reduce component loss. Ferulic acid and stilbene glucoside are easily decomposed and converted under heat, the component loss can be reduced by accurately controlling the temperature, and the quality of the liquid medicine before and after the medicine boiling operation is ensured to be stable.
TABLE 2 influence of the amount of compressed nitrogen introduced on the target ingredients in the Xintong oral liquid
As can be seen from Table 2, the higher content of compressed nitrogen during the filtration process maintained the ferulic acid content at a higher level and the ligustilide in a more stable state.
According to the test results, the temperature of the refrigerant introduced into the condenser is determined to be 4-15 ℃ in consideration of the actual conditions of large-scale production in a workshop and the requirements of energy conservation, consumption reduction and the like in the production process; preferably, the temperature of the introduced refrigerant is 4 ℃.
The foregoing has described the general principles and features of the present invention, as well as its advantages. It will be appreciated by persons skilled in the art that the above described embodiments are not to be considered limiting, and that any modifications and variations made based on the principles of the invention are intended to be within the scope of the invention as claimed.
Claims (10)
1. A multifunctional traditional Chinese medicine oral liquid refining combination system mainly comprises a medicine boiling tank (1), a filter (2) and a refrigerating tank (3), and is characterized in that:
medicine boiling tank (1) keeps dismantling through first conveying pipeline (4) and filter (2) and is connected, and simultaneously, cold-stored jar (3) keeps dismantling through second conveying pipeline (5) and filter (2) and is connected, and the three forms medicine boiling tank-filter-cold-stored jar combined system.
2. The multifunctional Chinese medicinal oral liquid refining combination system according to claim 1, wherein the medicine boiling tank (1) is provided with a first condenser (6) at the center of the top, a first compressed nitrogen inlet (7) at the left side of the top, a first feed inlet (8) at the right side of the top, a first steam heating valve (9) and a first refrigerant cooling valve (10) at the same time in the interlayer, a first temperature detector (11) at the inner side wall of the tank, a first stirring paddle (12) at the bottom inside the tank, and a first feed delivery pipe (4) controlled by a valve.
3. The multifunctional traditional Chinese medicine oral liquid refining combination system as claimed in claim 1, wherein a second condenser (13) is disposed at the center of the top of the refrigerating tank (3), a second compressed nitrogen inlet (15) is disposed at the left side of the top of the refrigerating tank, a second inlet (14) is disposed at the right side of the top of the refrigerating tank, a second steam heating valve (16) and a second refrigerant cooling valve (17) are disposed in the interlayer of the refrigerating tank, a second temperature detector (18) is disposed on the inner side wall of the refrigerating tank, a second stirring paddle (19) is disposed at the bottom of the refrigerating tank, and the second conveying pipe (5) is controlled by a valve.
4. The multifunctional traditional Chinese medicine oral liquid refining combination system according to any one of claims 1 to 3, wherein a first detachable stainless steel sealing partition plate (20) is arranged at two ends of the filter (2), and a first detachable stainless steel filtering clamping groove (21) is arranged inside the filter.
5. The multifunctional traditional Chinese medicine oral liquid refining combination system as claimed in claim 4, wherein the first detachable stainless steel sealing partition plate (20) of the filter (2) is a stainless steel circular plate with a thickness of 3-5cm, and the first detachable stainless steel filtering clamping groove (21) is a stainless steel circular ring with a thickness of 3-5 cm.
6. The multifunctional traditional Chinese medicine oral liquid refining combination system according to any one of claims 1 to 3, wherein a discharging device (22) with a filtering function is arranged on the right side of the bottom of the refrigerating tank (3), second detachable stainless steel sealing partition plates (23) are arranged at two ends of the refrigerating tank, a second detachable stainless steel filtering clamping groove (24) is arranged inside the refrigerating tank, and the second detachable stainless steel filtering clamping groove (24) is connected with an electric pump (25).
7. The multifunctional traditional Chinese medicine oral liquid refining combination system as claimed in claims 1 to 3, wherein the first condenser (6) and the second condenser (13) are internally composed of a hollow cylindrical pipeline surrounded by a spiral coil, the top ends of the first condenser (6) and the second condenser (13) are respectively provided with an exhaust port, and cooling water with the temperature of 4 ℃ to 15 ℃ is introduced into the spiral coil.
8. The multifunctional traditional Chinese medicine oral liquid refining combination system according to claim 7, wherein the temperature of cooling water introduced from the spiral coil pipe inside the first condenser (6) and the second condenser (13) is 4 ℃.
9. The multifunctional traditional Chinese medicine oral liquid refining combination system according to any one of claims 1 to 3, wherein the first compressed nitrogen inlet (7) is composed of an opening with an open end facing downward and forming an angle of 90 ° with the medicine boiling tank (1), and the second compressed nitrogen inlet (15) is composed of an opening with an open end facing downward and forming an angle of 90 ° with the refrigerating tank (3).
10. The multifunctional traditional Chinese medicine oral liquid refining combination system according to any one of claims 1 to 3, wherein a steam inlet of the first steam heating valve (9) is positioned at the lower left end of the medicine boiling tank (1), and a steam outlet of the first steam heating valve (9) is positioned at the upper right end of the medicine boiling tank (1); a steam inlet of the second steam heating valve (16) is positioned at the lower end of the left side of the refrigerating tank (3), and a steam outlet of the second steam heating valve (16) is positioned at the upper end of the right side of the refrigerating tank (3); preferably, a refrigerant inlet of the first refrigerant cooling valve (10) is positioned at the lower end of the right side of the medicine boiling tank (1), and a refrigerant outlet of the first refrigerant cooling valve (10) is positioned at the upper end of the left side of the medicine boiling tank (1); the refrigerant inlet of the second refrigerant cooling valve (16) is positioned at the lower end of the right side of the refrigeration tank (3), and the refrigerant outlet is positioned at the upper end of the left side of the refrigeration tank (3).
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107470039A (en) * | 2017-08-01 | 2017-12-15 | 鲁南制药集团股份有限公司 | A kind of Alcohol-settling tank, horizontal screw centrifuge combined system |
| CN108434200A (en) * | 2018-05-10 | 2018-08-24 | 湖南康尔佳制药股份有限公司 | A kind of preparation method and device of oral pulse-invigorating liquid |
| CN208406296U (en) * | 2018-01-29 | 2019-01-22 | 山东中顺新材料有限公司 | Pipeline filter device |
| CN208493315U (en) * | 2018-05-24 | 2019-02-15 | 广东生命一号药业股份有限公司 | A kind of extraction device for formulating of oral solution production |
| CN208925157U (en) * | 2018-06-15 | 2019-06-04 | 和平县维康食品有限公司 | A kind of fruit juice keeps in fresh-keeping oxidation |
| CN209204724U (en) * | 2018-11-29 | 2019-08-06 | 乐研新生物科技（成都）有限公司 | Medicinal refining and concentrating device in one kind |
| CN215022396U (en) * | 2020-12-18 | 2021-12-07 | 鲁南制药集团股份有限公司 | Multifunctional traditional Chinese medicine oral liquid refining combination system |
-
2020
- 2020-12-18 CN CN202011505523.3A patent/CN112704640A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107470039A (en) * | 2017-08-01 | 2017-12-15 | 鲁南制药集团股份有限公司 | A kind of Alcohol-settling tank, horizontal screw centrifuge combined system |
| CN208406296U (en) * | 2018-01-29 | 2019-01-22 | 山东中顺新材料有限公司 | Pipeline filter device |
| CN108434200A (en) * | 2018-05-10 | 2018-08-24 | 湖南康尔佳制药股份有限公司 | A kind of preparation method and device of oral pulse-invigorating liquid |
| CN208493315U (en) * | 2018-05-24 | 2019-02-15 | 广东生命一号药业股份有限公司 | A kind of extraction device for formulating of oral solution production |
| CN208925157U (en) * | 2018-06-15 | 2019-06-04 | 和平县维康食品有限公司 | A kind of fruit juice keeps in fresh-keeping oxidation |
| CN209204724U (en) * | 2018-11-29 | 2019-08-06 | 乐研新生物科技（成都）有限公司 | Medicinal refining and concentrating device in one kind |
| CN215022396U (en) * | 2020-12-18 | 2021-12-07 | 鲁南制药集团股份有限公司 | Multifunctional traditional Chinese medicine oral liquid refining combination system |
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