CN112691160A - Traditional Chinese medicine preparation for treating sphagitis - Google Patents
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating sphagitis, which consists of figwort root, radix ophiopogonis, dried rehmannia root, raw liquorice, thunberg fritillary bulb and mint.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine preparation for treating sphagitis.
Background
Pharyngitis can be divided into acute pharyngitis and chronic pharyngitis. Acute pharyngitis is acute inflammation of pharyngeal mucosa and submucosal tissues. Pharyngeal lymphoid tissue is often involved. Early inflammation may be limited, and the disease usually involves the entire pharyngeal cavity as it progresses, which is common in autumn, winter and spring. Chronic pharyngitis is also known as chronic simple pharyngitis and is more common. The pathological changes are mainly in the mucous membrane layer and are manifested as chronic congestion of the mucous membrane of the pharynx. Proliferation of mucous membrane and sub-mucosal connective tissue. The mucous glands are enlarged, the secretion function is enhanced, and the secretion of mucous is increased. It is common in adults, and has long course of disease and easy recurrence. Acute and chronic pharyngitis are common in clinic, the acute pharyngitis is an acute pathological process, the disease is acute and serious, and the chronic pharyngitis attacks repeatedly, so that a great deal of inconvenience is brought to life and work of patients.
According to the theory of traditional Chinese medicine, the pharynx is the stomach, the larynx is the lung, the larynx is easily injured by exogenous pathogenic factors entering the lung, the pharynx is easily injured by improper diet entering the stomach, and the larynx is a place where the pathogenic toxin is well soaked for a long time. The etiology of pharyngolaryngitis is clinically divided into internal and external factors, the external factor is mostly caused by wind-cold pathogen, and the long-standing heat or wind-heat pathogen, so that the traditional Chinese medicine "Wenzhi Bing Bian" is characterized in that the warm pathogen is suffered at the top, the lung is attacked at the first time, the throat is at the top, and the warm pathogen is felt at the first time; internal factors are mostly caused by yin deficiency, and addiction to spicy and fried food, accumulation of phlegm-heat and burning of the throat or consuming yin of lung and kidney for a long time, which causes up-flaming of deficient fire, burning of body fluid to produce phlegm, and phlegm-heat disturbing the throat along the meridian, resulting in loss of interest in clearing the channels, just as the pathological symptoms of throat impediment in the book of Yi Zong jin Jian: the chronic deficiency of kidney-yin causes the flaring-up of fire, which can lead to the generation of lung-heat and failure of the clearing and descending.
At present, western medicines for treating pharyngolaryngitis are many, but most of the medicines have poor treatment effects, and the side effects of the medicines can cause subsequent symptoms of dry throat, pharyngalgia and the like of a patient, and even influence the health of the patient in severe cases.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a traditional Chinese medicine preparation for treating sphagitis.
In order to solve the technical problems, the invention provides a traditional Chinese medicine preparation for treating sphagitis, which comprises the following medicine components: figwort root, Sichuan radix ophiopogonis, rehmannia root, raw licorice, thunberg fritillary bulb and mint.
Further, the traditional Chinese medicine composition comprises the following medicines in parts by weight: 6-8 parts of radix scrophulariae, 6-8 parts of radix ophiopogonis, 2-5 parts of radix rehmanniae, 2-3 parts of raw liquorice, 2-3 parts of thunberg fritillary bulb and 0.05-2 parts of mint.
Further, the mint is peppermint oil.
The invention also provides a method for preparing the traditional Chinese medicine preparation, which comprises the following steps:
1) taking and cleaning the medicinal materials according to the weight parts, adding water into the medicinal materials except the mint until the medicinal materials are submerged, and soaking;
2) decocting the medicinal materials soaked in the step 1) for 2 hours, filtering, adding water into the residues, continuing decocting for 1 hour, and filtering;
3) merging the filtrates obtained by twice filtration in the step 2), and filtering by using 8 layers of gauze;
4) refining the filtrate obtained in the step 3), and adding purified water to a sufficient amount;
5) boiling the liquid obtained in the step 4) again, cooling, and adding peppermint oil to obtain the traditional Chinese medicine preparation.
Further, the refining method comprises a water extraction and alcohol precipitation method and natural sedimentation.
The raw materials of the medicine in the prescription are as follows: figwort root: sweet, bitter, salty and slightly cold in nature, and has effects in invigorating spleen, stomach and kidney channels, clearing heat and cooling blood, nourishing yin and lowering fire, removing toxic substance and resolving hard mass; radix ophiopogonis: sweet, slight, bitter and cold in nature, enters lung, stomach and heart channels, nourishes yin, promotes the production of body fluid, moistens lung and clears heart; radix rehmanniae: sweet taste and cold nature, and can enter heart, liver and kidney channels, clear heat and cool blood, nourish yin and promote the production of body fluid; raw licorice root: sweet taste and neutral nature, and has effects of invigorating qi, strengthening middle warmer, relieving pain, moistening lung, relieving cough, clearing pathogenic fire, removing toxic substance, and harmonizing the other drugs; thunberg fritillary bulb: is cold in nature and bitter in taste, enters lung channel and heart channel, clears heat and removes stasis, and resolves phlegm and stops cough.
Compared with the prior art, the invention has the advantages that: the medicament and the adopted Chinese herbal medicines are all pure natural Chinese herbal medicines, have no toxic or side effect and low cost, and the medicament takes the theory of traditional Chinese medicine as guidance, has reasonable compatibility of the raw materials, has the effects of clearing and nourishing throat, reducing phlegm and quenching thirst, reducing swelling and relieving pain and the like by combining the medicines, and has the characteristics of exact curative effect, quick response, high cure rate, no side effect and the like when used for treating the sphagitis.
Detailed Description
The present invention will be described in detail with reference to the following examples.
Example 1: a traditional Chinese medicine preparation for treating sphagitis consists of the following medicine components: 6-8 parts of radix scrophulariae, 6-8 parts of radix ophiopogonis, 2-5 parts of radix rehmanniae, 2-3 parts of raw liquorice, 2-3 parts of thunberg fritillary bulb and 0.05-2 parts of peppermint oil.
The preparation method of the traditional Chinese medicine preparation comprises the following steps:
1) taking and cleaning the medicinal materials according to the weight parts, adding water into the medicinal materials except the mint until the medicinal materials are submerged, and soaking;
2) decocting the medicinal materials soaked in the step 1) for 2 hours, filtering, adding water into the residues, continuing decocting for 1 hour, and filtering;
3) merging the filtrates obtained by twice filtration in the step 2), and filtering by using 8 layers of gauze;
4) refining the filtrate obtained in the step 3), and adding purified water to a sufficient amount;
5) boiling the liquid obtained in the step 4) again, cooling, and adding peppermint oil to obtain the traditional Chinese medicine preparation;
6) the Chinese medicinal preparation is subpackaged, and the packaging amount of each bottle is 90 ml.
The traditional Chinese medicine preparation is oral liquid, and the administration of the oral liquid is generally three times a day, and 30ml of the oral liquid is taken each time.
Example 2: toxicity testing of the inventive Agents
The test was conducted by observing the acute toxicity of animals given the drug of the present invention orally.
The test animal of this experiment was a mouse, which was placed in the test environment for 3 days prior to the experiment, providing normal feed and drinking water during the experiment, laboratory temperature: 18-22 ℃, relative humidity: 30-50 percent.
The test process comprises the following steps: the liquid obtained by decocting and soaking the tested medicine is orally administrated to the mice 3 times every day, each time is about 5ml, each time is 4 hours, the total dose is 15ml, and the poisoning manifestation, the weight, the food intake and the death condition of the mice within 14 days are observed.
As a result: the mice showed normal behavior after oral administration, no death occurred within 14 days, and after the observation period, the mice were sacrificed and subjected to autopsy, and no obvious abnormality was seen in each major organ.
And (4) conclusion: the drug is decocted and soaked in 15ml of drug oral liquid every day, no death occurs after 14 days, and simultaneously no obvious abnormality is seen in main organs, so the drug belongs to the nontoxic level.
Example 3: clinical experiment curative effect of the medicine
1. Patient data
The pharyngolaryngitis patients who come from 1 month to 6 months in 2003 are 105 patients in total, wherein 49 men and 59 women are 16-60 years old, and the average age is 35 years old.
1) The diagnosis criteria for 105 patients in this example were as follows:
(1) phlegm-obstructing blood stasis type: dry and uncomfortable throat pain, burning sensation, foreign body sensation, pharynx itch and dry cough, little and sticky phlegm, mild symptoms at dusk, and symptoms of hectic fever in the afternoon, dysphoria and insomnia, dry stool, soreness and weakness of waist and knees, etc., and the inspection of dark red and dry throat mucosa, red and little saliva of tongue, little coating or peeling, and thready and rapid pulse;
(2) spleen-kidney yang deficiency type: slight sore throat, choking discomfort, no red and no swelling or slight whitish color in the throat, low voice, lassitude, clear and long urine, no fragrance in the received grain, cold hands and feet, soreness of waist and legs, light tongue, white and smooth fur, and deep, thready and weak pulse;
(3) phlegm-fire accumulation type: foreign body sensation, sticky phlegm or slight pain in the pharynx, nausea and vomiting, sticky phlegm with yellow sputum, halitosis, dark red pharynx, pachynsis, increased filtration of pharyngeal posterior wall, and lump fusion, pachynsis of pharyngeal lateral cord, reddened tongue or petechia, yellow and thick tongue coating, and thready, slippery and rapid pulse.
According to the diagnosis standard, 42 patients of 109 patients in the group are pharyngolaryngitis due to phlegm stagnation and blood stasis, 35 patients are pharyngolaryngitis due to spleen-kidney yang deficiency, and 32 patients are pharyngolaryngitis due to phlegm-fire stagnation, and the medicines are taken according to the medicine taking mode of the embodiment 1 and are continuously taken for 2 months.
2) The criteria for determining the therapeutic effect are as follows:
the effect is shown: the symptoms are relieved within 2 weeks after the medicine is taken, the clinical symptoms and physical signs disappear within 2 months, and no relapse occurs for more than 1 year (if the patient is suffered from cold, the pharyngeal discomfort does not exceed 10 days);
the method has the following advantages: the symptoms are relieved within 2 weeks after the medicine is taken, and the clinical symptoms and partial physical signs disappear within 2 months;
and (4) invalidation: after the medicine is taken, the symptoms are slightly reduced or not reduced, and the physical signs are not obviously improved.
2. Patient treatment
109 patients in the group are treated according to the example 1, and after 2 months of treatment, the treatment effect judgment standard is adopted, wherein 92 patients with significant effect account for 84.4 percent; 12 effective patients account for 11.0 percent; 3 invalid patients account for 2.75 percent, the total effective rate is 65.4 percent, and the curative effect statistical table is shown in table 1.
Table 1: therapeutic effect statistical table
Example 4: 105 patients with pharyngolaryngitis confirmed diagnosis are selected, and the inclusion standard of the patients in the group is as follows: the clinical symptoms are dry and burning throat, angina, foreign body sensation and the like, and the clinical symptoms can be seen as congestion of pharyngeal mucosa and hyperplasia of lymph follicles in different degrees;
1) exclusion criteria: patients are prone to cancer; other throat diseases are also complicated; other medications are used for treatment within a week. Patients in this group were randomly divided into two groups, experimental and control groups, 55 in the experimental group and 50 in the control group.
The experimental group takes the traditional Chinese medicine preparation of the invention 3 times a day, 30ml each time. The control group takes herba Pileae Scriptae buccal tablet 1 tablet 3 times daily. It is administered for 3 treatment courses, each course being 7 days.
2) Efficacy comparison criteria for this example
Has obvious effects that pharyngeal symptoms disappear and pharyngeal lymph follicles are obviously reduced.
Has the effects of basically eliminating pharyngeal symptoms, relieving chronic congestion of pharyngeal mucous membrane and reducing pharyngeal lymph follicles.
No effect, no change in symptom before and after treatment.
3) The results of the treatment are shown in Table 2
Table 2: clinical efficacy trial and experiment comparison
Example 5: typical case
Case 1: some Du Yi, male, 36 years old, dry and uncomfortable pharynx with foreign body sensation, and checking the tongue pale with white coating and slight pale inside throat for 2 months. The medicine is used for treatment, 60ml is taken each time, twice in 1 day, after 2 months of taking, clinical symptoms and physical signs disappear, and no relapse occurs in follow-up 2 years.
Case 2: plum, female and 23 years old are fond of eating spicy food, the throat is felt to have foreign body sensation before three months, the nausea and vomiting are easy, the sputum is sticky and yellow, the color of the throat is dark red, the mucous membrane is thick, the tongue is reddish or has petechia and petechia, and the tongue coating is yellow and thick, the clinical symptoms and physical signs disappear after the medicine is used for treating the throat, 60ml is taken twice every day for 1 day, and after the medicine is taken for more than 2 months, the throat does not relapse after 3 years follow-up visit.
The medicament formula of the invention is a pure Chinese medicinal preparation, is established for patients with pharyngolaryngitis, has no toxic or side effect, is safe and reliable in clinical application, has reasonable compatibility of raw materials, has the effects of clearing and nourishing throat, reducing phlegm, quenching thirst, reducing swelling, relieving pain and the like by combining the medicines, and has the characteristics of exact curative effect, quick response, high cure rate, no side effect and the like when being used for treating the pharyngolaryngitis.
The invention and its embodiments have been described above, without this being limitative. In summary, those skilled in the art should appreciate that they can readily use the disclosed conception and specific embodiments as a basis for designing or modifying other structures for carrying out the same purposes of the present invention without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (5)
1. A traditional Chinese medicine preparation for treating sphagitis is characterized by comprising the following medicine components: figwort root, Sichuan radix ophiopogonis, rehmannia root, raw licorice, thunberg fritillary bulb and mint.
2. The traditional Chinese medicine preparation for treating sphagitis according to claim 1, which is characterized by comprising the following medicines in parts by weight: 6-8 parts of radix scrophulariae, 6-8 parts of radix ophiopogonis, 2-5 parts of radix rehmanniae, 2-3 parts of raw liquorice, 2-3 parts of thunberg fritillary bulb and 0.05-2 parts of mint.
3. The traditional Chinese medicine preparation for treating sphagitis according to claim 1 or 2, wherein the mint is peppermint oil.
4. A method for preparing the traditional Chinese medicine preparation for treating sphagitis according to claim 3, which is characterized by comprising the following steps:
1) taking and cleaning the medicinal materials according to the weight parts, adding water into the medicinal materials except the mint until the medicinal materials are submerged, and soaking;
2) decocting the medicinal materials soaked in the step 1) for 2 hours, filtering, adding water into the residues, continuing decocting for 1 hour, and filtering;
3) merging the filtrates obtained by twice filtration in the step 2), and filtering by using 8 layers of gauze;
4) refining the filtrate obtained in the step 3), and adding purified water to a sufficient amount;
5) boiling the liquid obtained in the step 4) again, cooling, and adding peppermint oil to obtain the traditional Chinese medicine preparation.
5. The method for preparing a Chinese medicinal preparation for treating pharyngolaryngitis according to claim 4, wherein: the refining method comprises a water extraction and alcohol precipitation method and natural sedimentation.
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严玲: ""利咽饮治疗慢性咽炎178例"", 《湖北中医杂志》 * |
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Application publication date: 20210423 |