CN112675254A - Traditional Chinese medicine composition for treating Parkinson's disease gastrointestinal dysfunction and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating Parkinson's disease gastrointestinal dysfunction and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating Parkinson's disease gastrointestinal dysfunction and a preparation method thereof, wherein the traditional Chinese medicine composition is prepared from the following components, by weight, 10-20 parts of rhizoma atractylodis, 6-15 parts of mangnolia officinalis, 6-10 parts of pericarpium citri reticulatae, 10-15 parts of rhizoma anemarrhenae, 3-9 parts of coptis chinensis, 6-12 parts of elecampane and 10-30 parts of cistanche. Adding pharmaceutically acceptable carrier, and making into decoction, granule or oral preparation. The traditional Chinese medicine composition has wide raw material sources and low cost, can reduce the use of expensive medicines by promoting the medicine effect maintenance time of the existing PD medicines, has popularization and application values, has reasonable preparation formula components, has better curative effects on gastrointestinal dysfunction and motion symptoms proved by clinical cases, and is beneficial to realizing the prevention and control of PD chronic diseases.
Description
Technical Field
The invention belongs to the technical field of Parkinson disease treatment, and particularly relates to a traditional Chinese medicine composition for treating Parkinson disease gastrointestinal dysfunction.
Background
Parkinson's Disease (PD) is described by Parkinson first under the name paralysis agitans (paralysins) at 1817. PD is characterized by degeneration and loss of nigrostriatal Dopamine (DA) energy neurons and formation of lewy bodies, and is called as 'fibrillation disease, cerebral apoplexy, paralysis agitans' and the like in traditional Chinese medicine. PD is a common central nervous system degenerative disease of middle-aged and elderly people, and has a prevalence rate of about 1/100 in people over 55 years old and a total prevalence rate of 1700/10 ten thousand in people over 65 years old. PD is divided into two parts of motor symptoms and non-motor symptoms, gastrointestinal dysfunction in the non-motor symptoms is one of characteristics of Parkinson's disease throughout the whole process, disease motor disorders are aggravated from gastroparesis, constipation and SIBO to saliva and helicobacter pylori infection, and multiple retrospective studies show that PD of patients suffering from chronic inflammatory bowel disease is high in incidence rate, and intestinal leakage and intestinal glial cell activation caused by micro inflammation with increased intestinal permeability and endotoxin absorption play a crucial role in PD, however, a proper drug intervention method for treating PD gastrointestinal dysfunction is lacked at present. For example, 5-HT4 receptor agonists are withdrawn from gastroparesis due to cardiotoxicity; ghrelin, an Ghrelin agonist, improves gastrointestinal symptoms and has not yet been demonstrated to replicate the therapeutic effect in PD; multi-center clinical trials to evaluate parkinson's disease and chronic constipation are ongoing. There is a need to develop more effective treatments for PD gastrointestinal dysfunction.
The invention content is as follows:
in order to achieve the purpose, the invention provides a traditional Chinese medicine composition for preventing and treating gastrointestinal dysfunction of Parkinson disease and a preparation method thereof, which can improve non-motor symptoms of Parkinson disease patients.
In order to achieve the purpose, the traditional Chinese medicine composition for treating the gastrointestinal dysfunction of the Parkinson disease is prepared from the following components, by weight, 10-20 parts of rhizoma atractylodis, 6-15 parts of mangnolia officinalis, 6-10 parts of pericarpium citri reticulatae, 10-15 parts of rhizoma anemarrhenae, 3-9 parts of coptis chinensis, 6-12 parts of elecampane and 10-30 parts of cistanche.
The traditional Chinese medicine composition for treating the gastrointestinal dysfunction of the Parkinson disease also comprises a carrier accepted by a pharmacy department, and is prepared into decoction, granules, oral agents and the like known in the field.
The invention relates to a preparation method (decoction) of a traditional Chinese medicine composition for treating Parkinson disease gastrointestinal dysfunction, which comprises the following steps: soaking all the medicinal materials in parts by weight for 1-2 hours; boiling with strong fire, decocting with slow fire for 20-30 min, and controlling duration of fire to obtain thick and suitable medicinal liquid with deep and glossy color; filtering the residue, and collecting decoction. The method is suitable for early diagnosis of patients.
The invention relates to a preparation method (granules) of a traditional Chinese medicine composition for treating gastrointestinal dysfunction of Parkinson disease, which comprises the following steps: the preparation is carried out according to technical requirements for formulating quality control standards of traditional Chinese medicine formula granules, the medicinal materials are decocted and extracted by water according to a proportion, 8-12 times of water is added for extraction for 2-4 times, the extraction time is 1-2 h each time, lactose is selected as a granulating auxiliary material, and the proportion of the raw materials to the auxiliary material is 1: 1.2-1.8, and the drying temperature is 56-60 ℃. The method is used for patients carrying medicine or lack decocting condition.
The invention relates to a preparation method (ointment) of a traditional Chinese medicine composition for treating Parkinson's disease gastrointestinal dysfunction, which comprises the following steps: soaking and decocting the medicinal materials in proportion, taking the supernatant of the standing precipitate, heating and concentrating, adding 1-2 parts of ganoderma lucidum spore powder, 1-3 parts of broad bean fine powder and 5-10 parts of lotus seed and jujube paste auxiliary materials, and collecting the paste. The method is used in stable stage.
The invention discloses a formula of a Pingwei san-Xiang-Lian pill added with flavor, which is a main formula for clinically treating Parkinson's disease complicated with non-motor gastrointestinal symptoms such as SIBO, constipation, helicobacter pylori infection, gastroparesis and the like by an applicant team and consists of rhizoma atractylodis, mangnolia officinalis, dried orange peel, rhizoma anemarrhenae, coptis chinensis, elecampane and cistanche. The invention relates to Pingwei san Xianglian pills, belonging to the new application of old medicines. Stomach-calming is dispersed from the Song Dynasty's Taiping Huimin He Ji Ju Fang' which is a basic prescription for activating spleen and stomach to remove dampness and turbidity, Xianglian pills are from the 'administrative herbal medicine' which have remarkable effects of clearing heat and drying dampness, and according to the characteristics of old and weak body and kidney essence deficiency of patients, the added cistanche has the effects of tonifying kidney and replenishing essence and lubricating intestines. The pathogenesis of the traditional Chinese medicine of the disease generally belongs to deficiency and excess, and is the deficiency of qi, blood, yin and yang, wherein the deficiency of yin, fluid, essence and blood is the main reason; the wind, fire, phlegm and blood stasis are the symptoms. With the deep understanding and application of the theory of spleen and stomach in clinical evidence, it is believed that the generation of PD and the qi erosion of spleen and stomach, the qi movement up and down retardation and the transportation and transformation disorder of middle jiao are abnormal, the traditional Chinese medicine for PD is to recover the qi generated by spleen and stomach, and has the repeated effects of clearing heat and eliminating dampness, and the clinical practical application is usually combined with a treatment method of tonifying qi and activating blood, tonifying kidney and replenishing marrow, and calming liver and softening tendons according to the individual conditions of patients.
Compared with the existing medicine for treating the Parkinson disease, the invention has the following gain effects: (1) the raw materials have wide sources and low cost, can reduce the use of expensive medicaments by promoting the efficacy maintenance time of the existing PD medicaments, and has popularization and application values. (2) The preparation has reasonable formulation components, has better curative effect on gastrointestinal dysfunction and motion symptoms proved by clinical cases, and is beneficial to realizing the prevention and control of PD chronic diseases. (3) The protective intervention effect and the molecular mechanism of the medicine are demonstrated to PD gastrointestinal dysfunction, and a new treatment strategy and a feasible scheme are provided for PD modification protection treatment. (4) Tests and verifications on active ingredients, network pharmacology and the like lay a certain foundation for further developing a novel drug delivery system for treating the Parkinson disease by using the traditional Chinese medicine therapy.
Description of the drawings:
FIG. 1 is a graph showing the effect of Magnolol, a main active ingredient of the Chinese medicinal composition for treating Parkinson's disease gastrointestinal dysfunction in example 1, on the expression of PPAR γ in 3T3-L1 cells.
Fig. 2 is an electron microscope image of 6-OHDA-induced PC12 cells pretreated with magnol, which is the main active ingredient of the traditional Chinese medicine composition for treating parkinson's disease gastrointestinal dysfunction in example 1.
FIG. 3 shows the apoptosis of the major active ingredient Magnolol of the Chinese medicinal composition for treating Parkinson's disease gastrointestinal dysfunction in example 1 by flow cytometry.
FIG. 4 is a drawing of PD-Constipation-Chinese medicine Venn in example 1.
FIG. 5 shows the active ingredient-PD target regulation network and enrichment analysis in example 1.
The specific implementation mode is as follows:
the following further describes a specific embodiment of the present invention with reference to specific examples.
Example 1:
traditional Chinese medicine composition for treating Parkinson's disease gastrointestinal dysfunction
The invention relates to a traditional Chinese medicine composition for treating gastrointestinal dysfunction of Parkinson disease, which is prepared from the following components, by weight, 10-20 parts of rhizoma atractylodis, 6-15 parts of mangnolia officinalis, 6-10 parts of pericarpium citri reticulatae, 10-15 parts of rhizoma anemarrhenae, 3-9 parts of coptis chinensis, 6-12 parts of elecampane and 10-30 parts of cistanche.
The invention selects the formula according to the traditional Chinese medicine theory of treatment based on syndrome differentiation and the guidance of the brain-intestine-flora axis pathogenesis theory of the Parkinson's disease, creatively takes the treatment principles of strengthening and transporting spleen and stomach, clearing heat and drying dampness as the treatment principle, and adopts the method of flatting stomach and dispersing xianglian pills and adding cistanche to tonify kidney and replenish essence for old medicines. Clinical case studies show that the traditional Chinese medicine composition can effectively improve the gastrointestinal dysfunction of the Parkinson's disease, further relieve the motion symptoms, effectively prolong the action time of western medicines and adjust the common on-off phenomenon of PD; the experimental result shows that some active ingredients in the traditional Chinese medicine composition can obviously improve nerve injury induced by nerve agent 6-OHDA; based on the information research of a network database, the traditional Chinese medicine composition disclosed by the invention has an effective disease modification treatment protection effect on the Parkinson disease by regulating and controlling key target molecules and biological processes.
The invention aims to creatively develop a traditional Chinese medicine prescription for treating the Parkinson disease gastrointestinal dysfunction, and has the advantages that (1) the traditional Chinese medicine prescription has multiple stages: blocking from protective intervention at an early stage of the disease to the progressive stage of the disease; (2) multi-target property: from relieving chronic intestinal inflammation to regulating intestinal flora. On one hand, the microenvironment continuously provided for PD by the chronic inflammation of the intestinal tract is easy to generate DNA cumulative mutation and protein destruction to form abnormal functional protein; leading to the activation of microglia, and leading to the functional destruction of blood brain barrier tight junction protein caused by inflammatory cascade reaction, thereby causing the irreversible damage of neuron cells. On the other hand, the interaction between the gut flora and the host alters the risk of developing PD, as enterobacteriaceae is associated with abnormal posture and the severity of axial dyskinesia in gait disorders. In clinic, the applicant uses the traditional Chinese medicine formula to improve the gastrointestinal dysfunction of non-motor PD symptoms, and finds that the traditional Chinese medicine formula can effectively delay the whole disease process and prolong the medicine effect maintenance time of western medicines (MEDOA, SENFOLO and the like) through the evaluation of the curative effect of a case, thereby being finally beneficial to realizing the neuroprotective function in the management and control of PD chronic diseases.
It is proved that some active ingredients in the prescription can generate direct neuroprotective function.
One of the main active ingredients of the magnolia officinalis in the traditional Chinese medicine composition for treating the gastrointestinal dysfunction of the Parkinson disease is Magnolol. PPAR γ plays an important role in the pathogenesis of parkinson's disease. 3T3-L1 cells were differentiated in vitro into mature adipocytes under appropriate induction conditions, and we subcultured 3T3-L1 cells, as shown in FIG. 1, with the 6-OHDA group being 3T3-L1 cells treated with the nerve agent 6-OHDA induction, the Magnolol group being 3T3-L1 cells treated with Magnolol, and the control group being a blank control, and PPAR γ protein expression was detected by WB. From fig. 1, it can be observed that the expression of PPAR γ in the Magnolol group is enhanced, which proves that PPAR γ is activated by Magnolol, the expression of PPAR γ is obviously reduced after 6-OHDA acts on 3T3-L1 cells, and it can be presumed that the neurotoxic agent has the effect of inhibiting PPAR γ.
On the basis of the above, the choice was made to observe whether magnol could produce a direct neuroprotective effect in parkinson's disease. PC-12 cells, a rat adrenal medullary chromaffin tumor differentiated cell line, having general neuroendocrine properties, were subjected to in vitro PC12 cell experiments in which 6-OHDA group experiments induced PC12 cell damage with nerve agent 6-OHDA, Magnolo +6-OHDA group experiments added 50 μ M of Magnolo and nerve agent 6-OHDA sequentially to PC12 cells, 6-OHDA + Magnolo group experiments added nerve agent 6-OHDA and 50 μ M of Magnolo sequentially to PC12 cells, in the process of which PC12 control group without any treatment was set, and finally, survival of PC12 cells was observed by electron microscopy, showing that 6-OHDA group had a significantly reduced cell count compared to PC12 control group PC12 cell count, and Magnol +6-OHDA (50 μ M) group had an increased cell count compared to 6-OHDA group but less than PC12 group (FIG. 2). It was concluded that magnool was able to reduce apoptosis of 6-OHDA-induced PC12 cell damage. Different groups of apoptosis were seen using flow cytometry (figure 3): the 6-OHDA + Magnolol group showed less apoptosis than the 6-OHDA group. Therefore, it is inferred that after the nerve agent 6-OHDA induces the PC12 cell injury, the PC12 cell is exposed to Magnolol with increasing concentration, and under the specific concentration condition, the Magnolol has certain neuroprotective function by reducing cell death after the injury.
The network pharmacology technology is adopted to prove the action target point and mechanism approach of the medicine on PD gastrointestinal dysfunction
Firstly, the effective chemical components of the traditional Chinese medicine composition for treating the Parkinson disease gastrointestinal dysfunction are mined and screened from a public database, and the specific effects of the components are shown in Table 1. Further digging potential regulation targets of the active ingredients for the Parkinson disease gastrointestinal dysfunction. The method is used for treating Parkinson's disease and constipation and analyzing, a target-disease interaction Venn diagram (figure 4) is constructed, 124 common target genes are obtained, and therefore the key action target point for treating PD constipation is deduced. The interaction data of the target protein is led into Cytoscape _3.7.1 software to construct an active ingredient-action target-disease control network diagram (figure 4) of the traditional Chinese medicine composition for treating the Parkinson disease gastrointestinal dysfunction, and potential targets are found to be inflammatory factors IL1 beta, IL6, IL10R alpha, IL2, peroxisome proliferator-activated receptor PPAR gamma, hypoxia inducible factor HIF, dopamine metabolizing enzyme MAOB, apoptosis protein CASP3, solute carrier family SLC6A and the like. Further analysis, according to GO annotation results, shows that biological functions relate to bacteria-derived molecules, endotoxin, oxidative stress, anti-aging, iron metabolism, active oxygen metabolism and the like, and main functions are enriched in PI3K-Akt, TNF, IL-17, HIF-1 signal pathways and the like (figure 5).
In the embodiment, the effective chemical component of the traditional Chinese medicine composition for treating the Parkinson disease gastrointestinal dysfunction, namely the Parkinson disease gastrointestinal dysfunction target network topology analysis, is constructed, the protein interaction network is established, the core protein is obtained, GO analysis and KEGG analysis are carried out, and regulation evidence which is from a public database and supports the medicine to PD gastrointestinal dysfunction is obtained from the aspects of target molecules, biological functions and signal paths.
Example 2: typical cases of the medicine are listed in clinical application.
2020.9 Pengze, woman, age 55
The main complaints are: the bradykinesia is accompanied by involuntary shaking of limbs for more than 4 years.
With symptoms: patients have no obvious reason for hypokinesia in 2016, gradually progress the involuntary shaking of limbs, severe movement on the right side, poor fine movement, obvious breath, dry mouth, low emotion, stiff fingers in the morning, improvement after activity, hypodynamia, 1 time a day of defecation, light color and yellowish urine. 0.125g tid of Meiduo Ba is orally taken; senfuluo 0.25mg, Zhong0.125 mg, and evening 0.25 mg; 1mg of amban and tid', and the drug effect declines within 3-4 hours.
History of the past: history of chronic gastritis. Deny the history of drug and food allergy. Deny the history of hepatitis B and tuberculosis infection. Deny family history. Deny the contact history of toxic preparations such as pesticide.
Physical examination: shenqing, mental retardation, cranial nerve (-), muscle strength of four limbs V level, muscle tension increase of both lower limbs and right upper limb (+), fatigue test (+), resting tremor and sensory examination. The tongue is pale red, the coating is thin, white and greasy, and the pulse is thready and wiry.
Auxiliary inspection:
H-Y grading: grade 2.5
UPDRS scoring: 28 minutes
And (3) Western diagnosis: parkinson's disease
Traditional Chinese medicine diagnosis: tremor disease
Syndrome diagnosis: deficiency of both qi and blood
A prescription for diagnosis:
a main party: 10G of bran-fried rhizoma atractylodis, 10G of mangnolia officinalis, 10G of dried orange peel, 10G of rhizoma anemarrhenae, 3G of coptis chinensis, 10G of elecampane and 15G of cistanche
Adding and reducing drugs: 10G () of prepared rehmannia root, 10G of Chinese angelica, 10G of codonopsis pilosula, 10G of poria cocos, 10G of bran-fried bighead atractylodes rhizome, 15G of bran white paeony root, 15G of astragalus mongholicus, 20G of salvia miltiorrhiza, 15G of rhodiola rosea, 10G of fennel, 15G of turmeric, 6G of cassia twig, 10G of radix curcumae, 6G of honey polygala tenuifolia and 10G of scutellaria baicalensis.
Decocting 21 doses of water into 250ml of decoction, and taking one dose of the decoction every day in warm water
Square solution: decomposing the upper part, wherein the rhizoma atractylodis, the mangnolia officinalis and the dried orange peel in the main formula are used for strengthening the spleen and the stomach, the rhizoma coptidis, the rhizoma anemarrhenae and the elecampane are used for clearing heat and drying dampness, and belong to symptomatic experience medicines, the cistanche is used for replenishing essence and tonifying the kidney, and the rhizoma coptidis and the plus and minus formula are used for tonifying the kidney together with the middle-aged and mature parts to strengthen the body resistance, the codonopsis pilosula, the astragalus mongholicus, the rhizoma atractylodis macrocephalae and the poria; the cassia twig and the turmeric have pungent and warm natures and flavor, can help the stomach to clear yang and ascend, and can dredge orifices to ascend in a brain house; the scutellaria and the white paeony root have the functions of clearing heat and nourishing yin, and the whole formula combines with the viscera, meridians and collaterals and dialectics, and the main formula is used for experiential symptomatic application, thereby achieving good effect.
After 21 doses of the traditional Chinese medicine are taken, the emotion of a patient is improved, the breath and the dry mouth are relieved, and the traditional Chinese medicine is suitable for patients, 1-2 times a day, and the patients have dizziness, wake up for many times, dreaminess and content, the decline of the drug effect is delayed after the traditional Chinese medicine is taken, and the drug effect is maintained for more than 5 hours. A red tongue with a thin, white and greasy coating and a thready, wiry and diminished pulse.
Prescription II:
a main party: 10G of bran-fried rhizoma atractylodis, 10G of magnolia officinalis, 10G of dried orange peel, 10G of rhizoma anemarrhenae, 3G of coptis chinensis, 10G of elecampane and 15G of cistanche deserticola,
adding and reducing drugs: 10G of prepared rehmannia root, 10G of Chinese angelica, 10G of codonopsis pilosula, 10G of poria cocos, 10G of bran-fried bighead atractylodes rhizome, 15G of bran white paeony root, 15G of astragalus membranaceus, 20G of salvia miltiorrhiza, 15G of rhodiola rosea, 10G of fennel, 15G of turmeric, 6G of cassia twig, 10G of radix curcumae, 6G of honey polygala tenuifolia, 10G of scutellaria baicalensis and 15G of radix puerariae.
14 doses of the decoction are decocted in water for 250ml, and one dose is taken in two days at a low temperature
After 14 doses of the medicine are taken, the patient can exercise, and the patient can exercise about 5 hours after the medicine is taken as usual, the patient feels light and bitter in the mouth, the tongue coating is slightly yellow, and dizziness exists sometimes. In the formula, the rhodiola rosea has the functions of tonifying qi, activating blood and promoting blood circulation, the fennel has the function of warming the kidney and the spleen, and the kudzuvine root has the function of invigorating yang and promoting the production of body fluid.
Evaluation of the curative effect after administration:
H-Y grading: stage 2
UPDRS scoring: 20 minutes
The H-Y is graded and reduced, the reduction of the total score of UPDRS examination after treatment relative to the baseline is more than or equal to 30 percent, and the improvement of the curative effect is proved to be better.
Second medical record 2019.11 Sunzhi, Man, 79 years old
The main complaints are: the stiff limbs do not move for more than 2 years.
With symptoms: patients have no obvious inducement in 2017, and have the problems of inflexible movement of the two lower limbs, exertion after walking and difficulty in walking. Shaking the upper limbs. Accompanied by anorexia, short breath, palpitation, and dry stool 1 time every 2-3 days.
History of the past: physical examination. Deny the history of drug and food allergy. Deny the history of hepatitis B and tuberculosis infection. Deny family history. Deny the contact history of toxic preparations such as pesticide.
Physical examination: shenqing, mental retardation, cranial nerve (-), muscle strength of four limbs V level, muscle tension increase of both lower limbs and upper limbs (+), resting tremor and sensory examination. The tongue is red with thin coating, and the sublingual collaterals (++), the pulse is wiry and thready, short in the right cun and deep in both feet.
Auxiliary inspection:
H-Y grading: grade 3
UPDRS scoring: 36 points of
And (3) Western diagnosis: parkinson's disease
Traditional Chinese medicine diagnosis: tremor disease
Syndrome diagnosis: internal stirring of wind and yang due to marrow-sea deficiency
A prescription for diagnosis:
a main party: 10G of rhizoma atractylodis, 10G of mangnolia officinalis, 10G of dried orange peel, 10G of rhizoma anemarrhenae, 3G of coptis chinensis, 10G of elecampane and 15G of cistanche.
Adding and reducing drugs: 15g of concha haliotidis, 10g of uncaria, 15g of poria cocos, 10g of codonopsis pilosula, 10g of angelica sinensis, 10g of medicinal cyathula root, 10g of fructus aurantii, 15g of spina date seed, 10g of white paeony root, 10g of salvia miltiorrhiza, 15g of parasitic loranthus and 6g of liquorice.
7 doses of the decoction are decocted in water for 250ml, and one dose is taken in two days at a low temperature
Square solution: the rhizoma atractylodis, the magnolia officinalis and the dried orange peel in the main formula are used for strengthening the spleen and the stomach, the coptis chinensis, the rhizoma anemarrhenae and the elecampane are used for clearing heat and drying dampness according to the experience of symptoms, and the cistanche deserticola is used for replenishing essence and tonifying the kidney. The pathogenesis is marrow-sea deficiency, endogenous wind-yang movement, "fascia of the liver main body", the pathological nature is deficiency and excess, concha haliotidis, uncaria and fructus aurantii are added to calm the liver, calm the wind and promote the circulation of qi, white paeony root and liquorice are added to relax the muscles and tendons, codonopsis pilosula and poria cocos tonify qi and invigorate the spleen, salvia miltiorrhiza, parasitic loranthus, medicinal cyathula root, blood circulation promoting and kidney tonifying, spina date seed is used for soothing the nerves.
After the patient takes 7 doses of the medicine, the patient has difficulty in walking, the leg is lifted better than before, and the two upper limbs shake. Short breath, palpitation, hypomnesis, anorexia, irritability, and defecation for 2-3 days and 1 time. The tongue is red with thin coating, the sublingual collaterals (+), the pulse is wiry and thready, the right cun is short, and the deep areas of both feet are relieved.
Prescription II:
a main party: 10G of rhizoma atractylodis, 6G of mangnolia officinalis, 10G of dried orange peel, 10G of rhizoma anemarrhenae, 3G of coptis chinensis, 10G of elecampane and 20G of cistanche.
Adding and reducing drugs: 20g of astragalus membranaceus, 15g of poria cocos, 15g of codonopsis pilosula, 15g of caulis polygoni multiflori, 10g of scutellaria baicalensis, 15g of prepared rhizome of rehmannia, 10g of platycladi seed, 6g of scorpion, 12g of ligusticum wallichii, 15g of spina date seed, 10g of radix paeoniae alba, 20g of fructus alpiniae oxyphyllae, 6g of liquorice, 10g of cassia twig, 20g of salvia miltiorrhiza, 10g of rhizoma acori graminei, 15g of concha haliotidis, 10g of uncaria
Decocting with 12 doses of water to 250ml, and taking one dose every day at a warm time
After 12 doses of the medicine are taken, the patient can better lift the legs, and the two upper limbs shake. Improve appetite, relieve shortness of breath, poor control of urination, relieve irritability, and defecate for 1 time in 2 days. A red tongue with thin coating, wiry and thready pulse, short cun on the right, and deep and diminished ulnar. Radix rehmanniae Preparata can be added in the prescription for tonifying liver and kidney, nourishing yin, nourishing blood and moistening dryness; the astragalus and the tuckahoe invigorate the spleen and replenish qi, and generate qi and blood; the salvia miltiorrhiza, the platycladi seed and the multiflower knotweed stem have the functions of nourishing blood, tonifying heart and soothing nerves, the scorpion strengthens the functions of calming wind, activating collaterals and stopping tremor, the grassleaf sweelflag rhizome has the functions of inducing resuscitation and refreshing mind, the sharpleaf galangal fruit has the functions of warming kidney and reducing urination, and the baical skullcap root has the functions of clearing heat and drying dampness.
A main party: 10G of rhizoma atractylodis, 10G of mangnolia officinalis, 10G of dried orange peel, 10G of rhizoma anemarrhenae, 3G of coptis chinensis, 10G of elecampane and 15G of cistanche.
Adding and reducing drugs: 20g of astragalus membranaceus, 15g of poria cocos, 15g of codonopsis pilosula, 15g of caulis polygoni multiflori, 10g of scutellaria baicalensis, 6g of wine-processed rheum officinale, 15g of rhizoma alismatis, 6g of scorpio, 12g of ligusticum wallichii, 15g of spina date seeds, 10g of radix paeoniae alba, 20g of salvia miltiorrhiza, 15g of loranthus parasiticus, 15g of concha haliotidis, 10g of uncaria, 10g of peach kernels, 15g of herba lycopi, 15g of fructus rosae laevigat.
Decocting with 12 doses of water to 250ml, and taking one dose every day at a warm time
In the formula, the wine is prepared from rhubarb for clearing heat and toxic materials, peach kernel and herba lycopi for activating blood and dissolving stasis and inducing diuresis, the rhodiola rosea for tonifying qi and activating blood and invigorating pulse, and the cherokee rose fruit for reinforcing kidney and reducing urination. And (3) evaluating the curative effect after the medicine is taken:
H-Y grading: grade 3
UPDRS scoring: 27 minutes
The H-Y is graded and reduced, the reduction of the total score of UPDRS examination after treatment relative to the baseline is more than or equal to 20 percent, and the improvement of the curative effect is proved to be better. In the practical clinical application case, the medicines are added and decreased according to the syndrome differentiation and treatment traditional theory of the traditional Chinese medicine: (1) for syndrome of internal stirring of wind-yang (more frequent H-Y1-1.5), Tian Ma, Shi Jue Ming, Sheng Di, Gui ban, Tian Dong, etc. are commonly used. (2) For syndrome of wind-stirring due to phlegm-heat (more common in H-Y2-3 grades), ban Xia, Zhu Ru, Huang Qin, Fu Ling, Zhi Shi, Shi Chang Pu and Yu jin are commonly used. (3) For deficiency of both qi and blood (more common in H-Y2-4 level), Angelicae Gigantis radix, radix Codonopsis, Atractylodes rhizome, astragali radix, fructus Schisandrae, cortex et radix Polygalae, Zizyphi Spinosae semen, semen Platycladi, and Saviae Miltiorrhizae radix are commonly used. (4) For the syndrome of insufficient marrow sea (more common in H-Y3-4 grade), raw oyster, uncaria, medlar, prepared rhizome of rehmannia, white peony root, dwarf lilyturf tuber, etc. are commonly used. (5) For yang qi deficiency (more common in H-Y4-5 level), cinnamon, morinda officinalis, pulp of dogwood fruit, epimedium and rhodiola rosea are commonly used.
Claims (5)
1. A traditional Chinese medicine composition for treating Parkinson's disease gastrointestinal dysfunction is characterized by being prepared from the following components, by weight, 10-20 parts of rhizoma atractylodis, 6-15 parts of mangnolia officinalis, 6-10 parts of pericarpium citri reticulatae, 10-15 parts of rhizoma anemarrhenae, 3-9 parts of coptis chinensis, 6-12 parts of elecampane and 10-30 parts of cistanche.
2. The traditional Chinese medicine composition for treating Parkinson's disease gastrointestinal dysfunction according to claim 1, which is characterized by further comprising a pharmaceutically acceptable carrier, and the pharmaceutically acceptable carrier is prepared into decoction, granules or oral preparations known in the art.
3. A preparation method of the traditional Chinese medicine composition for treating the gastrointestinal dysfunction of the parkinson disease as claimed in claim 1, which is characterized in that all the medicinal materials in parts by weight are soaked for 1-2 hours; boiling with strong fire, decocting with slow fire for 20-30 min, and controlling duration of fire to obtain thick and suitable medicinal liquid with deep and glossy color; filtering the residue, and collecting decoction.
4. A preparation method of the traditional Chinese medicine composition for treating Parkinson disease gastrointestinal dysfunction, according to claim 1, is characterized in that the medicinal materials are decocted and extracted by water according to a certain proportion, 8-12 times of water is added for extraction for 2-4 times, the extraction time is 1h-2h each time, lactose is selected as a granulation auxiliary material, and the proportion of the raw materials to the auxiliary material is 1: 1.2-1.8, and the drying temperature is 56-60 ℃.
5. A preparation method of the traditional Chinese medicine composition for treating Parkinson disease gastrointestinal dysfunction, as claimed in claim 1, is characterized in that the medicinal materials are soaked and decocted according to a proportion, a supernatant fluid obtained after standing and precipitation is heated and concentrated, and 1-2 parts of ganoderma lucidum spore powder, 1-3 parts of broad bean fine powder and 5-10 parts of lotus seed and jujube paste-like auxiliary materials are added to obtain an ointment.
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| CN108837115A (en) * | 2018-09-29 | 2018-11-20 | 张广生 | It is a kind of to cure weakness of the spleen and the stomach cream taste and preparation method thereof |
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| CN108837115A (en) * | 2018-09-29 | 2018-11-20 | 张广生 | It is a kind of to cure weakness of the spleen and the stomach cream taste and preparation method thereof |
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| 周慎: "《全科医生方剂手册》", 31 August 2016 * |
| 宋永刚: "《临证本草讲读：一位二十年临床工作者的中药学讲稿》", 30 April 2014 * |
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