CN112675212A - Scutellaria baicalensis ointment and preparation method and application thereof - Google Patents
Scutellaria baicalensis ointment and preparation method and application thereof Download PDFInfo
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- CN112675212A CN112675212A CN202110049077.8A CN202110049077A CN112675212A CN 112675212 A CN112675212 A CN 112675212A CN 202110049077 A CN202110049077 A CN 202110049077A CN 112675212 A CN112675212 A CN 112675212A
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Abstract
The invention discloses a scutellaria ointment which is mainly prepared from the following raw materials: scutellaria root, borneol, stearic acid, glyceryl monostearate, liquid paraffin, glycerine, triethanolamine, ethylparaben and distilled water, and its preparation method includes the following steps: (1) decocting Scutellariae radix tablet in water twice, mixing decoctions, heating and concentrating with direct fire, and freeze drying to obtain Scutellariae radix extract powder; (2) putting stearic acid, glyceryl monostearate, castor oil and ethylparaben in a beaker, heating in water bath for complete dissolution to obtain a mixture A; (3) putting the glycerol, the scutellaria baicalensis extract powder and the distilled water into another beaker, heating to 50-60 ℃, adding triethanolamine while stirring to completely dissolve the scutellaria baicalensis extract powder to obtain a mixture B; and (4) adding borneol into the mixture A to obtain a mixture C, and then gradually adding the mixture C into the mixture B while stirring uniformly to room temperature to obtain the borneol-. The radix scutellariae ointment has the advantages of high efficiency and no side effect.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparation, and in particular relates to a scutellaria baicalensis ointment and a preparation method thereof.
Background
The Scutellariae radix is dried root of Scutellaria baicalensis Georgi of Labiatae, has been used for thousands of years in China, and is safe and harmless. Baikal skullcap root is first recorded in the Chinese herbal medicine of Shennong Ben Cao Jing, and is recorded in the form of Baikal skullcap root, bitter and flat in taste, all kinds of fever, jaundice, intestine , diarrhea, water retention, bleeding obstruction, malignant boil, deep-rooted carbuncle and fire ulcer. The scutellaria has the functions of clearing away heat, purging fire, detoxicating, arresting bleeding, preventing abortion, etc. and has the functions of resisting oxidation, eliminating free radical, resisting inflammation, resisting tumor, preventing calcium channel, inhibiting aldose reductase, resisting virus, resisting allergy, etc. and protecting immunity, cardiac and cerebral blood vessel, digestive system, nerve system, etc.
The ointment prepared from scutellaria baicalensis is already available on the market for treating diseases, but the existing baicalein ointment has single component and long drug effect release time, and the scutellaria baicalensis mainly contains baicalin, baicalein and other components which have pharmacological effects of resisting bacteria, resisting tumors, resisting inflammation, resisting allergy, resisting oxidation and the like. After the extraction, the comprehensive components contained in the scutellaria baicalensis extract powder obtained by freeze drying have the effect which is more in line with the characteristics of traditional Chinese medicine pharmacy based on the traditional Chinese medicine theory.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides the baicalein ointment which has the advantages of reasonable formula, obvious curative effect, simple preparation method, no side effect, no drug residue and effective baicalein.
The raw materials of the invention are all from Chinese herbal medicines, and the scutellaria baicalensis ointment is scientifically prepared, and the medicine has the functions of antibiosis, tumor resistance, inflammation resistance, allergy resistance, oxidation resistance and the like.
In order to realize the purpose of the invention, the adopted technical scheme is as follows:
the scutellaria ointment is characterized by being mainly prepared from the following raw materials: scutellaria root, borneol, stearic acid, glyceryl monostearate, liquid paraffin, glycerine, triethanolamine, ethylparaben and distilled water.
Preferably, the ointment mainly comprises the following raw materials in parts by weight: 50-100 parts of scutellaria baicalensis, 0.5-1 part of borneol, 30-60 parts of stearic acid, 10-20 parts of glyceryl monostearate, 50-100 parts of liquid paraffin, 20-60 parts of glycerol, 0.5-1 part of triethanolamine, 0.25-0.5 part of ethylparaben and 100-200 parts of distilled water.
Preferably, the ointment mainly comprises the following raw materials in parts by weight: 50 parts of scutellaria baicalensis, 0.5 part of borneol, 30 parts of stearic acid, 10 parts of glycerin monostearate, 50 parts of liquid paraffin, 20 parts of glycerol, 0.5 part of triethanolamine, 0.25 part of ethylparaben and 100 parts of distilled water.
Preferably, the ointment mainly comprises the following raw materials in parts by weight: 100 parts of scutellaria baicalensis, 1 part of borneol, 60 parts of stearic acid, 20 parts of glycerin monostearate, 100 parts of liquid paraffin, 60 parts of glycerin, 1 part of triethanolamine, 0.5 part of ethylparaben and 200 parts of distilled water.
The invention also provides a preparation method of the scutellaria baicalensis ointment, which comprises the following steps:
(1) decocting Scutellariae radix slice with water twice, mixing decoctions, heating and concentrating with direct fire, and freeze drying to obtain Scutellariae radix extract powder;
(2) putting stearic acid, glyceryl monostearate, castor oil and ethylparaben in a beaker, heating in water bath for complete dissolution to obtain a mixture A;
(3) putting the glycerol, the scutellaria baicalensis extract powder and the distilled water into another beaker, heating to 50-60 ℃, adding triethanolamine while stirring to completely dissolve the scutellaria baicalensis extract powder to obtain a mixture B;
(4) adding Borneolum Syntheticum into mixture A to obtain mixture C, gradually adding mixture C into mixture B, stirring, and cooling to room temperature to obtain ointment.
Furthermore, the pharmaceutical composition is a preparation prepared from crude drug powder of the raw drug materials according to the weight ratio.
Further, each time of decoction is 1 h.
Further, in the step (2), heating the mixture in a water bath to 60-70 ℃.
Further, the radix scutellariae ointment is applied to antibiosis, tumor resistance, anti-inflammation, anti-allergy and antioxidation.
The invention has the advantages and beneficial effects that:
1. the radix scutellariae ointment has the advantages of safe use, high cure rate, good treatment effect and the like in the aspects of treatment of antibiosis, tumor resistance, inflammation resistance, allergy resistance, oxidation resistance and the like.
2. The clinical application result shows that the radix scutellariae ointment has quick effect and no side effect.
3. The radix scutellariae ointment has the characteristics of preparation of both principal and secondary aspects, simple preparation process, good treatment effect, no toxic or side effect, reliable curative effect, low price, convenient use, no side effect, no drug residue and difficulty in generating drug resistance, and is worthy of clinical popularization and use.
Detailed Description
The invention will now be described in further detail with reference to the following examples, which are given for the purpose of illustration only and are not intended to limit the scope of the invention. The experimental methods used in the following examples are all conventional methods unless otherwise specified, and materials, reagents and the like used in the following examples are commercially available unless otherwise specified.
The inventor has long-term research on the antibacterial effect of the traditional Chinese medicine and has deep understanding on the efficacy and compatibility rule of the traditional Chinese medicine commonly used for treating the diseases. Under the guidance of the theory of traditional Chinese medicine, the recipe is finally formulated through prescription screening and clinical experimental statistical observation. The scutellaria ointment of the invention comprises the following components:
baikal skullcap root is used as main ingredient. It is bitter and cold in taste, and has effects of clearing heat and eliminating dampness, purging pathogenic fire and removing toxic substance, stopping bleeding, preventing miscarriage, etc. It can be used for treating epidemic febrile disease, upper respiratory infection, cough due to lung heat, yellow gallbladder due to damp-heat, pneumonia, dysentery, hemoptysis, conjunctival congestion, threatened abortion, hypertension, carbuncle, furuncle, and sore. The clinical antibacterial property of scutellaria is better than that of coptis, and the scutellaria does not produce drug resistance.
Example 1
The scutellaria ointment mainly comprises the following raw materials in parts by weight: 50 parts of scutellaria baicalensis, 0.5 part of borneol, 30 parts of stearic acid, 10 parts of glycerin monostearate, 50 parts of liquid paraffin, 20 parts of glycerol, 0.5 part of triethanolamine, 0.25 part of ethylparaben and 100 parts of distilled water.
The preparation method comprises the following steps:
(1) decocting Scutellariae radix tablet in water twice, mixing decoctions, heating and concentrating with direct fire, and freeze drying to obtain Scutellariae radix extract powder;
(2) putting stearic acid, glyceryl monostearate, castor oil and ethylparaben in a beaker, heating in water bath for complete dissolution to obtain a mixture A;
(3) placing glycerin, scutellaria baicalensis extract powder and distilled water into another beaker, heating to 50-60 ℃, adding triethanolamine while stirring to completely dissolve baicalein to obtain a mixture B; and
(4) adding Borneolum Syntheticum into mixture A to obtain mixture C, gradually adding mixture C into mixture B, stirring, and cooling to room temperature to obtain ointment.
Example 2
The scutellaria ointment mainly comprises the following raw materials in parts by weight: 100 parts of scutellaria baicalensis, 1 part of borneol, 60 parts of stearic acid, 20 parts of glycerin monostearate, 100 parts of liquid paraffin, 60 parts of glycerin, 1 part of triethanolamine, 0.5 part of ethylparaben and 200 parts of distilled water.
The preparation method comprises the following steps:
(1) decocting Scutellariae radix tablet in water twice, mixing decoctions, heating and concentrating with direct fire, and freeze drying to obtain Scutellariae radix extract powder;
(2) putting stearic acid, glyceryl monostearate, castor oil and ethylparaben in a beaker, heating in water bath for complete dissolution to obtain a mixture A;
(3) putting the glycerol, the scutellaria baicalensis extract powder and the distilled water into another beaker, heating to 50-60 ℃, adding triethanolamine while stirring to completely dissolve the scutellaria baicalensis extract powder to obtain a mixture B; and
(4) adding Borneolum Syntheticum into mixture A to obtain mixture C, gradually adding mixture C into mixture B, stirring, and cooling to room temperature to obtain ointment.
Example 3
The scutellaria ointment mainly comprises the following raw materials in parts by weight: 70 parts of scutellaria baicalensis, 0.7 part of borneol, 55 parts of stearic acid, 15 parts of glycerin monostearate, 80 parts of liquid paraffin, 45 parts of glycerol, 0.7 part of triethanolamine, 0.75 part of ethylparaben and 150 parts of distilled water.
The preparation method comprises the following steps:
(1) decocting Scutellariae radix tablet in water twice, mixing decoctions, heating and concentrating with direct fire, and freeze drying to obtain Scutellariae radix extract powder;
(2) putting stearic acid, glyceryl monostearate, castor oil and ethylparaben in a beaker, heating in water bath for complete dissolution to obtain a mixture A;
(3) putting the glycerol, the scutellaria baicalensis extract powder and the distilled water into another beaker, heating to 50-60 ℃, adding triethanolamine while stirring to completely dissolve the scutellaria baicalensis extract powder to obtain a mixture B; and
(4) adding Borneolum Syntheticum into mixture A to obtain mixture C, gradually adding mixture C into mixture B, stirring, and cooling to room temperature to obtain ointment.
The efficacy of the present invention is demonstrated by the following experimental examples.
(1) Processing raw medicinal materials
1) Extracting Scutellariae radix with ethanol to obtain Scutellariae radix extract;
2) extracting with water and precipitating with ethanol to obtain Scutellariae radix extract;
3) extracting with water and precipitating with ethanol to obtain Scutellariae radix extract, and freeze drying to obtain Scutellariae radix dry extract fine powder;
4) baicalein ointment prepared in example 2 was used;
(2) preparation of agar base
Preparing a ringer's solution: 0.85g of sodium chloride, 0.03g of potassium chloride and 0.048g of calcium chloride are taken and added with water until 100ml is dissolved.
Adding 2g of agar into the ringer's solution, heating in a water bath to dissolve, cooling to 60 ℃, adding a plurality of drops of ferric trichloride test solution, uniformly mixing, immediately pouring into 8 same test tubes preheated in advance, marking the test tubes as No. 1, 2, 3, 4, 5, 6, 7 and 8 respectively, wherein the loading amount is about 2cm away from the mouth of the test tube, pouring along the tube wall when pouring, avoiding mixing bubbles, standing vertically and solidifying for later use;
(3) taking the different ointments prepared in the step (1), respectively filling the different ointments into test tubes with agar matrixes in the step (2), wherein the different ointments are filled in the same amount, namely 1-2 No. 1 is a water extraction and alcohol precipitation method to obtain a scutellaria baicalensis extract, 3-4 No. 3 is an alcohol extraction method to obtain a scutellaria baicalensis extract, 5-6 No. 5 is a baicalein ointment prepared in the example 2, 7-8 No. 7 is a water extraction and alcohol precipitation method to obtain a scutellaria baicalensis extract, freeze-drying the scutellaria baicalensis extract to obtain scutellaria baicalensis dry extract fine powder, and then placing the scutellaria baicalensis dry extract fine powder in a constant temperature box (37 ℃) for a certain time to measure the penetration distance (namely the length of. Filling the measured data into table 1;
TABLE 1
| 0.5h | 1h | 2h | 4h | 8h | 12h | 24h | 48h | |
| 1 | 0.4cm | 0.4cm | 0.6cm | 0.9-3cm | 1.2-3.2cm | 1.3-3cm | 1.7-3.2cm | 2.3cm-3.2cm |
| 2 | 0.5cm | 0.5cm | 0.7cm | 0.9-3.5cm | 1.3-3.6cm | 1.5-5.1cm | 2-5.1cm | 2.7cm-5.1cm |
| 3 | 0.2cm | 0.2cm | 0.4cm | 0.5cm | 0.8cm | 1cm | 1.3cm | 1.6cm |
| 4 | 0.4cm | 0.4cm | 0.5cm | 0.6cm | 0.8cm | 1cm | 1.5cm | 1.6cm |
| 5 | 0cm | 0.1cm | 0.3cm | 0.3cm | 0.2cm | 0.3cm | 0.3cm | 0.4cm |
| 6 | 0cm | 0cm | 0.2cm | 0.3cm | 0.2cm | 0.3cm | 0.3cm | 0.4cm |
| 7 | 0.4cm | 0.4cm | 0.5cm | 0.8cm | 1.1cm | 1.1cm | 1.6cm | 1.9cm |
| 8 | 0.5cm | 0.8cm | 0.8cm | 1.1cm | 1.4cm | 1.9cm | 2.1cm | 3cm |
As can be seen from table 1, the radix scutellariae ointment prepared by the embodiment has the advantages of good release, good effect, no side effect, no drug residue, low price and easy acquisition, and is worthy of clinical popularization and application.
The above description is only an embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that are not thought of through the inventive work should be included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope defined by the claims.
Claims (8)
1. The scutellaria ointment is characterized by being mainly prepared from the following raw materials: scutellaria root, borneol, stearic acid, glyceryl monostearate, liquid paraffin, glycerine, triethanolamine, ethylparaben and distilled water.
2. The scutellaria ointment of claim 1, which is prepared from the following raw materials in parts by weight: 50-100 parts of scutellaria baicalensis, 0.5-1 part of borneol, 30-60 parts of stearic acid, 10-20 parts of glyceryl monostearate, 50-100 parts of liquid paraffin, 20-60 parts of glycerol, 0.5-1 part of triethanolamine, 0.25-0.5 part of ethylparaben and 100-200 parts of distilled water.
3. The scutellaria ointment of claim 2, which is prepared from the following raw materials in parts by weight: 50 parts of scutellaria baicalensis, 0.5 part of borneol, 30 parts of stearic acid, 10 parts of glycerin monostearate, 50 parts of liquid paraffin, 20 parts of glycerol, 0.5 part of triethanolamine, 0.25 part of ethylparaben and 100 parts of distilled water.
4. The scutellaria ointment of claim 2, which is prepared from the following raw materials in parts by weight: 100 parts of scutellaria baicalensis, 1 part of borneol, 60 parts of stearic acid, 20 parts of glycerin monostearate, 100 parts of liquid paraffin, 60 parts of glycerin, 1 part of triethanolamine, 0.5 part of ethylparaben and 200 parts of distilled water.
5. The method for preparing the ointment of scutellaria baicalensis as claimed in any one of claims 1 to 4, which comprises the following steps:
(1) decocting Scutellariae radix tablet in water twice, mixing decoctions, heating and concentrating with direct fire, and freeze drying to obtain Scutellariae radix extract powder;
(2) putting stearic acid, glyceryl monostearate, castor oil and ethylparaben in a beaker, heating in water bath for complete dissolution to obtain a mixture A;
(3) placing glycerin, scutellaria baicalensis extract powder and distilled water into another beaker, heating to 50-60 ℃, adding triethanolamine while stirring to completely dissolve baicalein to obtain a mixture B; and
(4) adding Borneolum Syntheticum into mixture A to obtain mixture C, gradually adding mixture C into mixture B, stirring, and cooling to room temperature to obtain ointment.
6. The method for preparing ointment of Scutellariae radix of claim 5, wherein in step (1), decocting is carried out for 1h each time.
7. The method for preparing baicalein ointment as claimed in claim 5, wherein in the step (2), the ointment is heated to 60-70 ℃ in water bath.
8. Use of the scutellaria ointment of any one of claims 1-4 for antibacterial, anti-tumor, anti-inflammatory, anti-allergic, and anti-oxidant purposes.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116492358A (en) * | 2023-04-10 | 2023-07-28 | 陕西中医药大学 | Application of scutellarin monomer |
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- 2021-01-14 CN CN202110049077.8A patent/CN112675212A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 程敏: "《中药药剂学实验指导》", 31 July 2016, 东南出版社 * |
| 郝翠等: "正交试验法优选黄芩配方颗粒的水提工艺", 《中国民族民间医药》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116492358A (en) * | 2023-04-10 | 2023-07-28 | 陕西中医药大学 | Application of scutellarin monomer |
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