CN112674801A - Urine collector capable of storing DNA in urine - Google Patents
Urine collector capable of storing DNA in urine Download PDFInfo
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- CN112674801A CN112674801A CN202011413326.9A CN202011413326A CN112674801A CN 112674801 A CN112674801 A CN 112674801A CN 202011413326 A CN202011413326 A CN 202011413326A CN 112674801 A CN112674801 A CN 112674801A
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Abstract
The invention discloses a urine collector capable of storing DNA in urine, which comprises a urine cup and a storage tube, wherein the urine cup is provided with a storage tube; the urine cup comprises a urine cup body and a urine cup cover; the lower end of the urine cup body is provided with a sample outlet; the preservation tube comprises a preservation tube body and a preservation tube cover; urine preservation liquid is contained in the tube body of the preservation tube; the end surface of the sample outlet is coated with an aluminum foil; the preservation tube cover is provided with a cutting strip, and the cutting strip is used for cutting the aluminum foil so that urine flows out of the sample outlet into the preservation tube when the urine cup and the preservation tube are combined. According to the invention, the collection and storage of urine are simultaneously carried out through the structural design of the collector, the effect of storing urine DNA is achieved mainly by mixing the urine storage liquid and the urine sample, and the collector has the advantages of simple and compact structure and simplicity and convenience in use.
Description
Technical Field
The invention belongs to the field of medical instruments, and particularly relates to a urine collector capable of storing DNA in urine.
Background
Most of the end products of metabolism produced by the human body during metabolism are excreted out of the body through the urinary system in the form of urine. More than 96% of urine is water, and contains human metabolic end products such as inorganic salts, saccharides, proteins, uric acid, urea and the like. Small amounts of cellular components, such as leukocytes, erythrocytes, epithelial cells, phagocytes, etc., are found in urine, and one can detect DNA from urine samples.
Urothelial tumors (UC) have become the most common tumor in urological clinical work, with higher incidence. Because the expected life span of the urothelial cancer is long and the recurrence rate is high, how to conveniently and quickly diagnose the urothelial tumor has important significance for treating the urothelial tumor.
Currently, the main diagnostic methods for urothelial tumors are imaging, cystoscopy and pathological biopsy. Among them, cystoscopy has always been the gold standard for diagnosis of urothelial tumors due to its high sensitivity and specificity and feasible pathological biopsy. However, cystoscopy is an invasive examination, which can cause great psychological and physiological pain to the patient, and secondly cystoscopy cannot diagnose upper urinary tract urothelial tumors and urothelial tumors that cannot be identified by the naked eye. Thus by developing urine biomarkers for non-invasive urothelial cancer detection, the reliance on cystoscopy can be reduced, thereby improving the patient experience of the examination. And the identification of the biomarkers can better guide the postoperative management of the patients and improve the prognosis of the patients.
The traditional auxiliary examination means urine cytology examination has high specificity and economical efficiency, but has lower sensitivity and has certain requirements on the experience of pathologists, such as a small amount of soluble urine protein biomarkers (NMP22, BTA) or exfoliative cell tests based on protein (Immuno Cyt) or aneuploid (Uro Vysion); inexperienced pathologists may miss diagnosis because of the insignificant nuclear heterogeneity of their low-grade urothelial tumors.
Recently, liquid biopsy technology has attracted more and more attention, and liquid biopsy is a non-invasive detection method using body fluids such as blood, urine, saliva and the like as detection carriers. The principle is that the tumor is detected by detecting the substances released to body fluid by tumor cell necrosis. And a new generation of sequencing methods: the advent of Next Generation Sequencing (NGS) and digital PCR (dd PCR) technologies has made it possible to find minute amounts of tumor DNA (tulour DNA) in large amounts of non-tumor DNA. Researchers have published data on mutations in ddPCR methods for detecting common FGFR3 and PIK3CA in free dna (cf dna) and circulating tumor dna (ct dna) in urine. This study demonstrated that the level of cf DNA in the urine of non-basal invasive bladder cancer (NMIBC) patients was positively correlated with the staging, grade and size of the tumor. High initial levels of urine cf DNA are predictive of future levels of disease progression. Recent studies on the analysis of DNA copy number, methylation status and somatic mutation changes in urine cell pellets have shown the potential of liquid biopsy as an accurate non-invasive bladder cancer detection method.
There are some similar implementations, but the following disadvantages exist: 1. the urine is easy to spill 2 when collected, the common urine cup is thin, is not anti-skid and is easy to break or turn over 3, the common urine cup is not provided with a cover and is easy to have microbial contamination 4, the urine is easy to leak or turn over when poured into the storage tube from the urine cup, and the hands may touch the urine, so that the operation is inconvenient.
Therefore, a urine collector which has a simple structure and is easy and convenient to use and can store DNA in urine is needed.
Disclosure of Invention
The invention aims to provide a urine collector capable of storing DNA in urine, which can be applied to subsequent physical examination, in-vitro diagnosis and other examinations.
In order to achieve the purpose, the technical scheme of the invention is as follows:
in one aspect, the invention provides a urine collector capable of storing DNA in urine, which comprises a urine cup and a storage tube;
the urine cup comprises a urine cup body and a urine cup cover; the lower end of the urine cup body is provided with a sample outlet;
the preservation tube comprises a preservation tube body and a preservation tube cover; urine preservation liquid is contained in the tube body of the preservation tube and is used for protecting the stability of DNA, inhibiting bacteria and inhibiting the functions of DNA enzyme;
the end surface of the sample outlet is coated with an aluminum foil for preventing leakage when urine is collected;
the preservation tube cover is provided with a cutting strip which is used for cutting the aluminum foil when the urine cup and the preservation tube are combined so that urine can flow out of the sample outlet into the preservation tube.
As a further improvement of the embodiment of the invention, the urine cup body is provided with a splash-proof barrier strip, and the splash-proof barrier strip is arranged on the inner wall of the urine cup body and is arranged in the direction vertical to the circumferential section of the urine cup body and used for draining urine so as to prevent urine from splashing out.
As a further improvement of the embodiment of the invention, the outer side wall of the urine cup body is provided with a non-slip strip for increasing the friction force of holding the urine cup body by hand.
As a further improvement of the embodiment of the invention, the bottom of the urine cup body is provided with a first anti-falling skirt.
As a further improvement of the embodiment of the invention, a first external thread is arranged on the upper part of the outer surface of the urine cup body, and a first internal thread matched with the first external thread is arranged on the inner surface of the urine cup cover.
As a further improvement of the embodiment of the present invention, the outer peripheral wall of the sample outlet is provided with a second external thread, and the inner surface of the storage tube cap is provided with a second internal thread matching with the second external thread.
As a further improvement of the embodiment of the invention, the bottom of the tube body of the preservation tube is provided with a second anti-falling skirt.
As a further improvement of the embodiment of the invention, the cutting strip is arranged at the position where the aluminum foil can be cut for 2mm when the urine cup and the preservation tube are combined and configured.
In another aspect, the present invention provides a method for using a urine collector capable of storing DNA in urine, the method comprising the following steps:
s1, collecting about 20-50mL of urine sample by using a urine cup, and covering a lid of the urine cup after collection;
s2, combining and configuring the urine cup and the storage tube;
s3, after the urine sample in the urine cup completely flows into the preservation tube, the preservation tube is unscrewed clockwise, the preservation tube cover is covered, and the urine cup is discarded;
and S4, turning the storage tube upside down and mixing the mixture for 10 times, and finishing the collection of the urine sample.
As a further improvement of the embodiment of the present invention, the step of disposing the urine cup and the storage tube in combination in step S2 includes: opening the tube cover of the preservation tube, wherein the opening of the tube body of the preservation tube is propped against the sample outlet below the urine cup and is screwed anticlockwise by aiming at the thread; in the screwing process, the cutting strip in the storage tube can cut the aluminum foil at the sample outlet for about one circle, and the urine sample in the urine cup can flow into the storage tube below.
The invention has the following beneficial effects:
according to the invention, the collection and storage of urine are simultaneously carried out through the structural design of the collector, the effect of storing urine DNA is achieved mainly by mixing the urine storage liquid and the urine sample, and the collector has the advantages of simple and compact structure and simplicity and convenience in use.
Drawings
FIG. 1 is a schematic structural view of a urine cup according to an embodiment of the present invention;
FIG. 2 is a schematic structural diagram of a storage tube according to an embodiment of the present invention;
the examples in the figures are represented as:
a urine cup 1; a urine cup body 11; a sample outlet 111; a second external thread 1111; an aluminum foil 112; a splash barrier 113; cleats 114; a first anti-falling skirt 115; a first external thread 116; a urine cup cover 12; a first internal thread 121; a storage tube 2; a storage tube body 21; a second anti-falling skirt 212; a storage tube cap 22; a cutting bar 221; a second internal thread 222; urine preservative fluid 23.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Unless otherwise specified, the reagents used in the following examples are commercially available from normal sources.
Preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings.
In order to achieve the purpose, the technical scheme of the invention is as follows:
the invention provides a urine collector capable of storing DNA in urine, which comprises a urine cup 1 and a storage tube 2;
the urine cup 1 comprises a urine cup body 11 and a urine cup cover 12; the lower end of the urine cup body 11 is provided with a sample outlet 111;
the preservation tube 2 comprises a preservation tube body 21 and a preservation tube cover 22; urine preservative fluid 23 is contained in the preservation tube body 21 and is used for protecting the stability of DNA, inhibiting bacteria and inhibiting the functions of DNA enzyme;
the end surface of the sample outlet 111 is coated with an aluminum foil 112 for leakage prevention during urine collection;
the tube cover 22 of the storage tube is provided with a cutting strip 221 for cutting the aluminum foil 112 when the urine cup 1 and the storage tube 2 are combined so that urine can flow out of the sample outlet 111 into the storage tube 2.
Preferably, urine cup 11 is provided with splash proof barrier 113, and splash proof barrier 113 is arranged at the inner wall of urine cup 11, and sets up in the circumferential cross section direction of perpendicular to urine cup 11 for play the drainage effect to the urine and prevent the spill of urine.
Further, the outer side wall of the urine cup body 11 is provided with a slip-proof strip 114 for increasing the friction force for holding the urine cup body 11.
Further, the bottom of the urine cup body 11 is provided with a first anti-falling skirt 115.
Furthermore, a first external thread 116 is arranged on the upper part of the outer surface of the urine cup body 11, and a first internal thread 121 matched with the first external thread 116 is arranged on the inner surface of the urine cup lid 12.
Further, the outer peripheral wall of the sample outlet 111 is provided with a second external thread 1111, and the inner surface of the storage tube cover 22 is provided with a second internal thread 222 that engages with the second external thread 1111.
Wherein, the bottom of the tube body 21 is provided with a second anti-falling skirt 212.
The cutting strip 221 is provided at a position where the aluminum foil 112 can be cut by the remaining 2mm when the urine cup 1 is disposed in combination with the holding tube 2.
On the other hand, the invention provides a using method of the urine collector capable of preserving DNA in urine, which comprises the following steps:
s1, collecting about 20-50mL of urine sample by using a urine cup, and covering a lid of the urine cup after collection;
s2, combining and configuring the urine cup and the storage tube;
s3, after the urine sample in the urine cup completely flows into the preservation tube, the preservation tube is unscrewed clockwise, the preservation tube cover is covered, and the urine cup is discarded;
and S4, turning the storage tube upside down and mixing the mixture for 10 times, and finishing the collection of the urine sample.
Wherein the step of disposing the urine cup and the storage tube in combination in step S2 includes: opening the tube cover of the preservation tube, wherein the opening of the tube body of the preservation tube is propped against the sample outlet below the urine cup and is screwed anticlockwise by aiming at the thread; in the screwing process, the cutting strip in the storage tube can cut the aluminum foil at the sample outlet for about one circle, and the urine sample in the urine cup can flow into the storage tube below.
The invention has the following beneficial effects:
according to the invention, the collection and storage of urine are simultaneously carried out through the structural design of the collector, the effect of storing urine DNA is achieved mainly by mixing the urine storage liquid and the urine sample, and the collector has the advantages of simple and compact structure and simplicity and convenience in use.
The above is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, many variations and modifications can be made without departing from the inventive concept of the present invention, which falls into the protection scope of the present invention.
Claims (10)
1. A urine collector capable of storing DNA in urine is characterized by comprising a urine cup and a storage tube;
the urine cup comprises a urine cup body and a urine cup cover; the lower end of the urine cup body is provided with a sample outlet;
the preservation tube comprises a preservation tube body and a preservation tube cover; urine preservation liquid is contained in the tube body of the preservation tube and is used for protecting the stability of DNA, inhibiting bacteria and inhibiting the functions of DNA enzyme;
the end surface of the sample outlet is coated with an aluminum foil for preventing leakage when urine is collected;
the preservation tube cover is provided with a cutting strip which is used for cutting the aluminum foil when the urine cup and the preservation tube are combined so that urine can flow out of the sample outlet into the preservation tube.
2. The urine collector capable of storing DNA in urine as claimed in claim 1, wherein the urine cup body is provided with a splash-proof bar, the splash-proof bar is arranged on the inner wall of the urine cup body and is arranged in the direction perpendicular to the circumferential section of the urine cup body for draining urine to prevent urine from splashing out.
3. The urine collector capable of storing DNA in urine as claimed in claim 1, wherein the outer side wall of the urine cup body is provided with an anti-slip strip for increasing the friction force for holding the urine cup body by hand.
4. The urine collector capable of storing DNA in urine as claimed in claim 1, wherein the bottom of the cup body of the urine cup is provided with a first anti-falling skirt.
5. The urine collector capable of storing DNA in urine as claimed in claim 1, wherein the upper part of the outer surface of the urine cup body is provided with a first external thread, and the inner surface of the urine cup cover is provided with a first internal thread matched with the first external thread.
6. The urine collector capable of storing DNA in urine as claimed in claim 1, wherein the outer peripheral wall of the sample outlet is provided with a second external thread, and the inner surface of the tube cover of the storage tube is provided with a second internal thread matched with the second external thread.
7. The urine collector capable of storing DNA in urine as claimed in claim 1, wherein the bottom of the tube body of the storage tube is provided with a second anti-falling skirt.
8. The urine collector capable of storing DNA in urine as claimed in claim 1, wherein the cutting strip is disposed at a position where the aluminum foil can be cut by 2mm when the urine cup is assembled with the storage tube.
9. A use method of a urine collector capable of preserving DNA in urine is characterized by comprising the following steps:
s1, collecting about 20-50mL of urine sample by using a urine cup, and covering a lid of the urine cup after collection;
s2, combining and configuring the urine cup and the storage tube;
s3, after the urine sample in the urine cup completely flows into the preservation tube, the preservation tube is unscrewed clockwise, the preservation tube cover is covered, and the urine cup is discarded;
and S4, turning the storage tube upside down and mixing the mixture for 10 times, and finishing the collection of the urine sample.
10. The urine collector capable of storing DNA in urine according to claim 1, wherein the step of arranging the urine cup and the storage tube in combination in step S2 comprises: opening the tube cover of the preservation tube, wherein the opening of the tube body of the preservation tube is propped against the sample outlet below the urine cup and is screwed anticlockwise by aiming at the thread; in the screwing process, the cutting strip in the storage tube can cut the aluminum foil at the sample outlet for about one circle, and the urine sample in the urine cup can flow into the storage tube below.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011413326.9A CN112674801A (en) | 2020-12-02 | 2020-12-02 | Urine collector capable of storing DNA in urine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011413326.9A CN112674801A (en) | 2020-12-02 | 2020-12-02 | Urine collector capable of storing DNA in urine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112674801A true CN112674801A (en) | 2021-04-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011413326.9A Pending CN112674801A (en) | 2020-12-02 | 2020-12-02 | Urine collector capable of storing DNA in urine |
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| Country | Link |
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| CN (1) | CN112674801A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4203169A (en) * | 1977-09-14 | 1980-05-20 | Medeci Developments Limited | Urine collection device |
| JP3119434U (en) * | 2005-08-16 | 2006-03-02 | 有限会社 アザ | Mixing container |
| CN202837040U (en) * | 2012-10-10 | 2013-03-27 | 青岛市市立医院 | Urine collector |
| WO2018057938A1 (en) * | 2016-09-23 | 2018-03-29 | Trovagene, Inc. | Comprehensive system for collecting, processing, processing and analyzing cell free nucleic acids in urine |
-
2020
- 2020-12-02 CN CN202011413326.9A patent/CN112674801A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4203169A (en) * | 1977-09-14 | 1980-05-20 | Medeci Developments Limited | Urine collection device |
| JP3119434U (en) * | 2005-08-16 | 2006-03-02 | 有限会社 アザ | Mixing container |
| CN202837040U (en) * | 2012-10-10 | 2013-03-27 | 青岛市市立医院 | Urine collector |
| WO2018057938A1 (en) * | 2016-09-23 | 2018-03-29 | Trovagene, Inc. | Comprehensive system for collecting, processing, processing and analyzing cell free nucleic acids in urine |
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Application publication date: 20210420 |