CN112641879A - Traditional Chinese medicine composition for relieving fatigue and preparation method thereof - Google Patents
Traditional Chinese medicine composition for relieving fatigue and preparation method thereof Download PDFInfo
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- CN112641879A CN112641879A CN202011500401.5A CN202011500401A CN112641879A CN 112641879 A CN112641879 A CN 112641879A CN 202011500401 A CN202011500401 A CN 202011500401A CN 112641879 A CN112641879 A CN 112641879A
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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Abstract
The invention discloses a traditional Chinese medicine composition for relieving fatigue and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30-50 parts of poria cocos, 20-40 parts of Chinese yam, 10-30 parts of wolfberry fruit, 10-30 parts of rhizoma polygonati, 10-30 parts of polygonatum odoratum and 5-20 parts of ginseng. Animal function experiments show that the traditional Chinese medicine composition can improve the weight swimming time of mice, the weight swimming time of the mice in each experimental group is longer than that of a control group, the blood lactic acid content and the serum urea nitrogen level of each experimental group are lower than those of the control group, and the traditional Chinese medicine composition has the effect of relieving physical fatigue.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparations, health products or foods, and particularly relates to a traditional Chinese medicine composition for relieving fatigue and a preparation method thereof.
Background
Fatigue refers to the decline of the activity after a certain period of time and to a certain extent, which is manifested as fatigue, muscular soreness or general weakness. The most physiological nature of fatigue is the effect on energy metabolism due to muscle activity. Traditional Chinese medicine has different names according to different situations of human body fatigue. Such as: fatigue, weakness, lassitude, exhaustion, Jiexian, five kinds of fatigue, seven kinds of exhaustion, etc. For different people and different conditions, fatigue can be manifested on different parts, including lassitude of the limbs, soreness and weakness of the waist and legs, lassitude, asthenopia, slow reaction, etc. Fatigue can not be completely recovered for a long time, such as frequent overstraining training, improper training requirement improvement and improper work and rest arrangement, the function of cerebral cortex is damaged, the nerve-body fluid regulation function is disordered, and the functional states of each organ and system are abnormally changed, so that the fatigue is transferred into the overstrained state, namely, the mental state is transferred into the pathological state. The symptoms mainly include attention deficit, hypomnesis, training performance decline, inappetence, weight loss, sleepiness and insomnia, dizziness, neurasthenia, high heart rate in quiet state, even heart enlargement, pathological noise and the like after long-term use.
The traditional Chinese medicine holds that the kidney stores essence, governs bone and produces marrow, is the innate foundation, is the prime motive power and the source of physical strength, and the spleen is the acquired foundation, produces qi and blood, governs muscles of limbs, and is vigorous in muscle and weak in spleen due to splenic abundance. The liver governs smoothing flow of qi and storing blood. Sufficient liver blood can strengthen muscles and bones, exercise flexibly, resist fatigue and relieve fatigue quickly. Liver blood deficiency, failure of the tendons and vessels to nourish leads to lassitude and hypodynamia, or fatigue easily after exercise, and the fatigue relieving speed is slow.
The prior art of medicines, health products or foods for relieving fatigue mainly has the following defects:
defect one: has great toxic and side effects and poor safety.
And defect two: the process is complicated and the cost is high.
And a third defect: the curative effect is poor.
At present, the western medicine has no effective treatment means for the fatigue of sub-health, and the traditional Chinese medicine has unique points for the recognition and the intervention of the fatigue from the perspective of 'treating diseases and preventing diseases'. The traditional Chinese medicine preparation, the health care product or the food have rich and various raw materials, have the characteristics and advantages of small side effect, high safety and prevention and treatment combination, can achieve the aim of treating both symptoms and root causes, and have been more and more accepted and regarded by many people. Moreover, the health-care food for relieving physical fatigue is suitable for a large number of people, has large market demand and good public base, and has wide market prospect.
For the above reasons, further research on medicines, health-care products or foods for relieving fatigue is needed to solve the problems of great toxic and side effects, poor safety, complex process, high cost and poor curative effect of common medicines, health-care products or foods for relieving fatigue.
Disclosure of Invention
The invention mainly aims to provide a traditional Chinese medicine composition for relieving fatigue and a preparation method thereof, and aims to solve the problems that common medicines, health-care products or foods for relieving fatigue in the prior art have large toxic and side effects, poor safety, complex process, high cost and poor curative effect.
In order to achieve the above object, according to one aspect of the present invention, there is provided a traditional Chinese medicine composition for relieving fatigue, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30-50 parts of poria cocos, 20-40 parts of Chinese yam, 10-30 parts of wolfberry fruit, 10-30 parts of rhizoma polygonati, 10-30 parts of polygonatum odoratum and 5-20 parts of ginseng.
Further, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 35-45 parts of poria cocos, 30-40 parts of Chinese yam, 20-30 parts of wolfberry fruit, 10-20 parts of rhizoma polygonati, 10-20 parts of polygonatum odoratum and 10-15 parts of ginseng.
Further, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 40 parts of poria cocos, 35 parts of Chinese yam, 25 parts of wolfberry fruits, 15 parts of rhizoma polygonati, 15 parts of polygonatum odoratum and 15 parts of ginseng.
According to another aspect of the invention, the application of the traditional Chinese medicine composition in preparing traditional Chinese medicine preparations, health products or foods for relieving fatigue is provided.
According to another aspect of the present invention, there is provided a Chinese medicinal preparation, health product or food comprising the above Chinese medicinal composition.
Further, the Chinese medicinal preparation, the health-care product or the food is a solid beverage.
According to another aspect of the present invention, there is provided a method for preparing the above-mentioned chinese medicinal preparation, health product or food, comprising the steps of:
(1) extraction: weighing appropriate amount of poria cocos, Chinese yam, wolfberry fruits, sealwort, polygonatum odoratum and ginseng, mixing according to a proportion, adding 10-20 times of water or 50-95% of alcohol for extraction for 0.5-2 h, wherein the extraction times are 1-3 times, filtering, combining extracting solutions, and concentrating under reduced pressure to obtain a concentrated solution;
(2) and (3) drying: adding a first auxiliary material into the concentrated solution, fully and uniformly stirring, drying and collecting dry powder;
(3) granulating; adding a second auxiliary material and a flavoring agent into the dry powder, uniformly mixing, granulating and sieving;
(4) packaging: and packaging the sieved granules to obtain the traditional Chinese medicine preparation, the health-care product or the food.
Further, the first and second excipients are the same or different.
Further, the first and second adjuvants are each selected from one or more of lactose, sugar powder, xylitol, dextrin, maltodextrin and sorbitol.
Further, the first excipient is maltodextrin.
Further, the second excipient is maltodextrin.
Furthermore, the adding amount of the first auxiliary material accounts for 13-18% of the weight of the concentrated solution.
Further, the flavoring agent is selected from one or more of a sweetener, an acidulant and a flavoring agent.
Further, the sweetener is selected from one or more of white granulated sugar, xylitol, sorbitol, erythritol, sucralose and stevioside.
Further, the sour agent is selected from one or more of citric acid, malic acid and vitamin C.
Further, the dry powder: the weight ratio of the second auxiliary material is 1 (0.5-2).
Further, the dry powder: the weight ratio of the sweetener is 1 (0.01-0.04).
Further, the dry powder: the weight ratio of the sour agent is 1 (0.035-0.055).
Further, the method of granulation is dry granulation.
Further, the drying manner is spray drying or freeze drying.
Further, the drying manner is spray drying.
By applying the technical scheme, the traditional Chinese medicine composition for relieving fatigue is prepared from the following raw materials in parts by weight: 30-50 parts of poria cocos, 20-40 parts of Chinese yam, 10-30 parts of wolfberry fruit, 10-30 parts of rhizoma polygonati, 10-30 parts of polygonatum odoratum and 5-20 parts of ginseng. The traditional Chinese medicine composition has the advantages of remarkably relieving physical fatigue and having no obvious toxic or side effect, thereby well solving the problems of large toxic or side effect, poor safety, complex process, higher cost and poor curative effect of common medicines, health care products or foods for relieving fatigue.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the embodiments of the present application, and it should be apparent that the described embodiments are some, but not all, embodiments of the present application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail with reference to examples.
The present invention is described in further detail below with reference to specific examples, which are not to be construed as limiting the scope of the invention as claimed herein.
As described in the background art, the existing medicines, health products or foods for relieving fatigue have the problems of large toxic and side effects, poor safety, complex process, high cost and poor curative effect. In order to solve the problems, the invention provides a traditional Chinese medicine composition for relieving fatigue, which is prepared from the following raw materials in parts by weight: 30-50 parts of poria cocos, 20-40 parts of Chinese yam, 10-30 parts of wolfberry fruit, 10-30 parts of rhizoma polygonati, 10-30 parts of polygonatum odoratum and 5-20 parts of ginseng.
In the invention, in the selection of raw materials, six medicinal and edible Chinese medicinal materials are selected according to screening, compounding and effect evaluation of more than dozens of Chinese medicinal herbs in literature research, so that the Chinese medicinal composition has good effect, can be taken for a long time and has no toxic or side effect.
Among the raw materials of the traditional Chinese medicine composition, the poria cocos has the effects of tonifying qi and spleen, and lightly permeating spleen and dampness, and can communicate heart and kidney, so that the spleen and the kidney are healthy; the Chinese yam has the effects of tonifying lung and spleen, reinforcing kidney and replenishing vital essence, can tonify deficiency of spleen qi, nourish yin essence of kidney, treat consumptive disease, relieve restlessness and fever, and tonify heart qi deficiency, is compatible with the tuckahoe, and the spleen is healthy and healthy to promote qi to grow, and can effectively help the source of acquired life; the medlar has the effects of nourishing yin and enriching blood, nourishing liver and kidney, and replenishing vital essence to improve eyesight; for those with spleen and stomach deficiency, there are liver and kidney deficiency syndrome, and for those with spleen and stomach deficiency, it is not tonifying when using only Gou Qi Zi, it is combined with shan Yao and Fu Ling, so there is no intestine-moistening disease; rhizoma Polygonati has effects of nourishing kidney yin, moistening lung dryness, invigorating spleen yin, and invigorating spleen qi, and is combined with fructus Lycii to tonify yin and yang, and has effects of replenishing essence; moreover, polygonatum sibiricum is mostly added into the spleen to supplement the acquired qi, and medlar is mostly added into the kidney to assist the innate qi, so the essence of both the innate qi and the acquired qi and blood and yin and yang is provided; yuzhu has effects of nourishing yin, moistening dryness, promoting fluid production to quench thirst, nourishing yin of lung and stomach, invigorating qi, replenishing blood, invigorating qi, generating yin, nourishing but not greasy, and can be used for treating deficiency of both qi and yin when being combined with rhizoma Polygonati; ginseng, radix Ginseng, being sweet and warm, has effects of invigorating qi, tonifying five internal organs, calming the mind, invigorating spleen, tonifying lung, invigorating qi, promoting fluid production, and invigorating primordial qi. The traditional Chinese medicine composition has the effects of nourishing yin, tonifying kidney, nourishing blood, controlling nocturnal emission and relieving physical fatigue by combining the medicines.
The beverage takes tuckahoe, yam, medlar, rhizoma polygonati, polygonatum odoratum and ginseng as main raw materials, and the tuckahoe, the yam, the medlar, the polygonatum odoratum and the ginseng are scientifically matched to play roles of tonifying qi and strengthening spleen and slightly permeating spleen dampness, so that the spleen and the kidney are strong, the yam, the kidney and the essence are strengthened, the medlar, the blood and the liver are nourished, the kidney and the sealwort, the qi, the yin, the spleen, the lung, the kidney, the polygonatum odoratum, the yin, the dryness and the body fluid are nourished, the. The medicines are combined to achieve the effects of nourishing yin and tonifying kidney, nourishing blood and controlling nocturnal emission and relieving physical fatigue. In addition, the health-care tea is processed by adopting a scientific and reasonable production process, is safe and reliable for long-term taking, has good taste and flavor and is convenient to drink and carry.
In order to further enhance the synergistic effect of the traditional Chinese medicine components in the traditional Chinese medicine composition, namely enhance the efficacy of the traditional Chinese medicine composition in relieving physical fatigue, in a preferred embodiment, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 35-45 parts of poria cocos, 30-40 parts of Chinese yam, 20-30 parts of wolfberry fruit, 10-20 parts of rhizoma polygonati, 10-20 parts of polygonatum odoratum and 10-15 parts of ginseng.
In order to further enhance the synergistic effect of the traditional Chinese medicine components in the traditional Chinese medicine composition, namely enhance the efficacy of the traditional Chinese medicine composition in relieving physical fatigue, in a preferred embodiment, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 40 parts of poria cocos, 35 parts of Chinese yam, 25 parts of wolfberry fruits, 15 parts of rhizoma polygonati, 15 parts of polygonatum odoratum and 15 parts of ginseng.
According to another aspect of the invention, the application of the traditional Chinese medicine composition in preparing traditional Chinese medicine preparations, health products or foods for relieving fatigue is provided.
According to another aspect of the present invention, there is provided a Chinese medicinal preparation, health product or food comprising the above Chinese medicinal composition.
In a preferred embodiment, the Chinese medicinal preparation, health product or food is a solid beverage.
The invention prepares the traditional Chinese medicine composition into the solid beverage, and overcomes the defects of time and labor waste, poor liquid medicine taste, inconvenient carrying and the like in the traditional Chinese medicine decoction process. It has the following advantages compared to liquid beverages: (a) the water content of the solid particles is low, microorganisms are not easy to reproduce, deterioration or putrefaction cannot be caused, and the solid particles are convenient to store and transport; (b) the weight is obviously reduced, the volume is obviously reduced, and the small bag is convenient to package and carry; (c) has good taste and flavor, good instant solubility and convenient drinking. Along with the economic development and the improvement of the living standard of people, people pay more and more attention to health, and functional solid beverages with health benefits are more and more popular. Therefore, many medicinal materials with homology of medicine and food need to be vigorously developed into instant solid beverages which not only have certain efficacy, but also have better taste and flavor, so as to meet the requirements of consumers, facilitate the carrying and long-term taking of people and promote the health of people.
According to another aspect of the present invention, there is provided a method for preparing the above-mentioned chinese medicinal preparation, health product or food, comprising the steps of:
(1) extraction: weighing appropriate amount of poria cocos, Chinese yam, wolfberry fruits, sealwort, polygonatum odoratum and ginseng, mixing according to a proportion, adding 10-20 times of water or 50-95% of alcohol for extraction for 0.5-2 h, wherein the extraction times are 1-3 times, filtering, combining extracting solutions, and concentrating under reduced pressure to obtain a concentrated solution;
(2) and (3) drying: adding a first auxiliary material into the concentrated solution, fully and uniformly stirring, drying and collecting dry powder;
(3) granulating; adding a second auxiliary material and a flavoring agent into the dry powder, uniformly mixing, granulating and sieving;
(4) packaging: and packaging the sieved granules to obtain the traditional Chinese medicine preparation, the health-care product or the food.
In the invention, in the processing technology, the raw materials are extracted by multiple water or alcohol extraction processes, so that a large amount of effective components in the raw materials can be dissolved out, and the effective components are enriched by a reduced pressure concentration process, thereby protecting the activity of the effective components of the product and improving the content and the biological absorption utilization rate of the effective components of the product.
In a preferred embodiment, the first and second excipients are the same or different.
In a preferred embodiment, the first and second excipients are each selected from one or more of lactose, sugar powder, xylitol, dextrin, maltodextrin and sorbitol.
In a preferred embodiment, the first excipient is maltodextrin.
In the invention, the maltodextrin has the best effect of improving the wall sticking property, can reduce the phenomenon of material wall sticking and obviously improves the collection rate of dry powder.
In a preferred embodiment, the second excipient is maltodextrin.
In the invention, the granules prepared by taking maltodextrin as the auxiliary material have good formability, uniform and consistent color, lower material granule hygroscopicity, prolonged storage time of products, relatively low price and easy purchase
In a preferred embodiment, the first excipient is added in an amount of 13-18% by weight of the concentrate.
In the present invention, when the amount of the first auxiliary material added is 13 to 18% by weight (based on the weight of the concentrate), preferably 15%, the spray drying can be normally performed, the powder collection rate is high, and the influence on the color, taste, aroma, etc. of the dry powder is small.
In a preferred embodiment, the flavoring agent is selected from one or more of a sweetener, an acidulant and a taste enhancer.
According to the invention, according to the characteristics of the raw material extract, the sweetening agent and the sour agent are preferably selected for flavoring, so that the plant solid beverage which has good taste and unique flavor, is not added with preservative and pigment and has the function of relieving physical fatigue is prepared.
In a preferred embodiment, the sweetener is selected from one or more of white granulated sugar, xylitol, sorbitol, erythritol, sucralose, and steviol glycosides.
In a preferred embodiment, the sweetener is a steviol glycoside.
In the invention, the stevioside serving as a sweetening agent has the advantages of low energy, high sweetness, pure sweet taste, high safety, capability of covering the bitter taste of a product, and good solubility and stability.
In a preferred embodiment, the acidulant is selected from one or more of citric acid, malic acid and vitamin C.
In a preferred embodiment, the acidulant is vitamin C.
In the invention, the product added with vitamin C has harmonious and soft flavor, can cover the bitter taste of the product, has proper acidity, prominent characteristic flavor, soft and harmonious mouthfeel, better taste and no influence on the properties of granules.
In the invention, the traditional Chinese medicine preparation, the health care product or the food selects tuckahoe, yam, medlar, sealwort, polygonatum and ginseng as raw materials, the raw materials are scientifically extracted, a certain amount of maltodextrin is added to dry the raw materials into powder, then a certain amount of maltodextrin, stevioside and vitamin C are added to be uniformly mixed, and the dry granulation is adopted to prepare the traditional Chinese medicine preparation, the health care product or the food, so that the traditional Chinese medicine preparation, the health care product or the food not only has the effects of nourishing yin and tonifying kidney, tonifying qi and strengthening spleen, and tonifying both qi and yin, but also selects the functional sweetener stevioside, has high sweetness, pure taste, no peculiar smell or bitter taste, and has a covering effect on unpleasant tastes such as astringent taste, bitter taste and the like, the safety is extremely; vitamin C not only provides sour taste which can be given to the product, but also can promote cell metabolism of human bodies, help cells to expel toxin, enable the cells to be always in an active functional state, maintain normal work, improve the immunity of the human bodies and the emergency capacity of the bodies, and ensure the normal functions of all organs.
In a preferred embodiment, the dry powder: the weight ratio of the second auxiliary material is 1 (0.5-2).
In a preferred embodiment, the dry powder: the weight ratio of the second auxiliary materials is 1:1.
In the invention, the ratio of the second auxiliary material to the dry powder is 1:1, and the prepared particles not only have better formability and uniform color, but also are not easy to absorb moisture and have good processing and storage effects.
In a preferred embodiment, the dry powder: the weight ratio of the sweetener is 1 (0.01-0.04).
In a preferred embodiment, the dry powder: the weight ratio of the sour agent is 1 (0.035-0.055).
In a preferred embodiment, the granulation process is dry granulation.
In the invention, the dry granulation process is adopted to prepare the granules, the operation is simple and convenient, the method is suitable for large-scale production, and the produced granules have good formability, uniform color, good solubility, easy packaging and are suitable for transportation and storage.
In a preferred embodiment, the drying is by spray drying or freeze drying.
In a preferred embodiment, the drying is by spray drying.
In the invention, the spray drying mode is adopted to prepare the dry paste powder, the water evaporation is rapid, the drying time is short, the efficiency is high, the loss of effective components is small, the product quality is good, and the powder is fine.
In addition, the inventor carries out experimental study on the technical scheme provided by the invention to prove the technical effect of the invention, and the following experiment is used for further explaining the technical effect of the invention, but does not limit the invention.
It should be noted that, if the specific conditions are not specified, the procedures are carried out according to the conventional conditions or the conditions recommended by the manufacturer, and the raw materials or auxiliary materials used, and the reagents or equipment used are not specified by the manufacturer, and are conventional products commercially available. All percentages, ratios, proportions, or parts are by weight unless otherwise specified.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. In addition, any methods and materials similar or equivalent to those described herein can be used in the practice of the present invention.
Examples
1. Spray drying adjuvant screening experiment
1.1 preparation of concentrated solution
4000g of poria cocos, 3500g of Chinese yam, 2500g of wolfberry fruit, 1500g of rhizoma polygonati, 1500g of polygonatum odoratum and 1500g of ginseng are mixed according to a proportion, 10 times of pure water is added for extraction, the extraction time is 1.0h, the extraction times are 2 times, the decoction is kept slightly boiling in the extraction process (the temperature of the decoction is controlled at 100 +/-5 ℃), and the two decoctions are combined to obtain a water extract; concentrating the water extraction liquid medicine by a rotary evaporator, controlling the concentration temperature to be 65 +/-5 ℃, controlling the vacuum degree to be-0.07 to-0.09 Mpa, and obtaining the relative density of the concentrated solution to be 1.05 to 1.10(60 ℃).
1.2 screening of auxiliary materials
Returning the concentrated solution to room temperature, and drying by a spray dryer: the air inlet temperature is set to be 170 ℃ (the fluctuation range is 170 +/-5 ℃) and the air outlet temperature is set to be 90-95 ℃, spray drying operation is carried out, the phenomenon that materials are stuck to the wall is very serious, the yield of collected dry powder is low, moisture absorption is easy to occur, and follow-up operation cannot be carried out.
The method is improved as follows: adding a certain amount of auxiliary materials into the concentrated solution, fully and uniformly stirring, and drying by a spray dryer: setting the air inlet temperature to be 170 ℃ (the fluctuation range is 170 +/-5 ℃), setting the air outlet temperature to be 90-95 ℃, and performing spray drying operation.
TABLE 1-1 Effect of different adjuvant types on powder Collection Rate
| Auxiliary materials | Addition amount (%) | Wall sticking phenomenon | Powder collecting Rate (%) |
| Lactose | 13 | Heavy weight | 36.5 |
| Dextrin | 13 | Heavy weight | 35.8 |
| Maltodextrin | 13 | Light and slight | 40.2 |
| Soluble starch | 13 | Severe severity of disease | 30.6 |
From the table 1-1, it can be known that different types of auxiliary materials have different influences on the powder collection rate, and under the condition of the same addition amount, the wall adhesion improving effects of the auxiliary materials are maltodextrin, lactose, dextrin and soluble starch in sequence, wherein the wall adhesion improving effect of the maltodextrin is the best, the wall adhesion phenomenon of materials can be reduced, and the powder collection rate of dry powder is obviously improved.
TABLE 1-2 Effect of different maltodextrin additions on the flour-collecting ratio
As can be seen from tables 1-2, different amounts of maltodextrin added have different effects on the wall sticking phenomenon and the powder collection rate of spray drying, with the powder collection rate being the highest with 18% maltodextrin. However, since a higher amount of maltodextrin added makes the color of the dry powder lighter, reduces the drug content, has a poor taste, and makes the intrinsic flavor lighter, it is necessary to reduce the amount of maltodextrin added by examining the wall sticking phenomenon and the powder collection rate to obtain an optimum amount of maltodextrin. From table 1, it is clear that when the amount of maltodextrin added is 13 to 18% by weight (based on the weight of the concentrate), and preferably 15%, the normal spray drying can be performed, the powder collection rate is high, and the influence on the color, taste, aroma, etc. of the dry powder is small.
2. Granulation auxiliary material screening and granulation method comparison experiment
The dry powder (maltodextrin addition amount is 15%) prepared by the spray drying auxiliary material screening experiment is uniformly mixed with different auxiliary materials, the wet granulation method and the dry granulation method are respectively adopted to prepare material granules, and the experimental results are shown in the following table.
TABLE 2-1 Effect of different adjuvants and granulation Process on the produced Material granules
The experimental results in table 2-1 show that the dry granulation method adopted in the granulation mode is significantly better than the wet granulation method, which not only can significantly shorten the granulation time, but also does not need a wetting agent and a drying process, thereby reducing the production cost and saving energy. The material particles prepared from different auxiliary materials are found to have good formability, uniform color, lower hygroscopicity of the material particles, prolonged storage time of products, relatively low price and easy purchase by comparing the material particles prepared from the maltodextrin, so that the maltodextrin is selected as the auxiliary material for granulation.
TABLE 2-2 Effect of different maltodextrin additions on the produced material particles
From table 2-2, it can be found that the granules prepared by the method have better formability and low hygroscopicity, but the higher addition amount of maltodextrin can lighten the color of the granules, reduce the drug content and lighten the peculiar smell of the granules. Therefore, the ratio of maltodextrin to dry powder is 1:1, and the prepared granules not only have better formability and uniform color, but also are not easy to absorb moisture and have good processing and storage effects.
3. Selection of sweetener and sour agent for solid beverage
3.1 preparation of solid beverages
Taking granulation auxiliary materials for screening and a granulation method, adopting dry granulation in a comparative experiment, uniformly mixing the auxiliary materials which are mixed powder of maltodextrin and dry powder in a ratio of 1:1 with sweetening agents and sour agents in different addition amounts, granulating by using a dry granulator, sieving the prepared granules by using a rotary sieve, and selecting the granules which can pass through a first sieve and the granules which can not pass through a fourth sieve to obtain qualified product granules.
3.2 organoleptic evaluation of solid beverages prepared with different sweeteners and acidulants
(1) Sensory evaluation
1.5g of each sample was taken, 200mL of purified water at about 90 ℃ was added thereto, the mixture was dissolved by stirring, and sensory evaluation was performed independently by 10 persons, and the average was taken as the sensory score.
TABLE 3-1 sensory evaluation criteria
(2) Sensory evaluation results
TABLE 3-2 sensory scores for granules prepared with different sweeteners
| Sweetening agent | Addition amount (%) | Sensory Scoring (score) |
| White granulated sugar | 10 | 86.8 |
| Xylitol, its preparation method and use | 10 | 85.6 |
| Sorbitol | 10 | 81.2 |
| Erythritol and its preparation method | 10 | 82.5 |
| Sucralose | 4 | 70.7 |
| Stevioside | 4 | 82.8 |
| Stevioside | 3 | 85.5 |
| Stevioside | 2 | 92.7 |
| Stevioside | 1 | 86.9 |
The experimental result shows that the sweetness is not obvious because the adding amount of the white granulated sugar, the xylitol, the sorbitol and the erythritol is less, but the excessive adding amount has influence on the hygroscopicity of the product. Therefore, sucralose with high sweetness and stevioside are selected as the sweetening agents, when the adding amount is 4%, the sweetness of the sucralose and the sweetness of the stevioside are both higher, and no obvious sweetness difference exists between the sucralose and the stevioside, but the stevioside has obvious sweet-returning feeling, and the bitter taste and other peculiar smell of the product are reduced, so the stevioside is preferably selected as the sweetening agent. When the stevioside with the addition of 2% is finally selected, the product has the advantages of highest sensory evaluation score, moderate sweetness, better mouthfeel, no bitter and astringent taste and other peculiar smells, and hardly provides heat. Stevioside is used as a sweetening agent, has low energy, high sweetness, pure sweetness and high safety, can cover the bitter taste of a product, and has good solubility and stability.
Table 3-3 sensory scores of granules prepared with different acidulants
| Sour agent | Addition amount (%) | Sensory Scoring (score) |
| Citric acid | 6 | 80.4 |
| Malic acid | 6 | 76.5 |
| Vitamin C | 6 | 82.8 |
| Vitamin C | 5.5 | 86.7 |
| Vitamin C | 5 | 88.2 |
| Vitamin C | 4.5 | 94.8 |
| Vitamin C | 4 | 90.7 |
| Vitamin C | 3.5 | 86.7 |
Experimental results show that the product acidity is higher due to the addition of 6% of citric acid, malic acid and vitamin C, wherein the product added with the citric acid has sour and astringent feeling and irritating feeling, the taste is not harmonious, the effect of covering the bitter taste of the product is small, and the odor of the malic acid covers the characteristic flavor of the product and cannot improve the bitter taste of the product. The product added with vitamin C has harmonious and soft flavor, can cover the bitter taste of the product, wherein the product added with 4.5 percent of vitamin C has proper acidity, prominent characteristic flavor, soft and harmonious taste, better taste and no influence on the properties of particles. Therefore, vitamin C is preferable as the acidulant, and the addition amount is preferably 4.5%.
According to the above results, the preferred sweetener is stevioside, and the preferred sour agent is vitamin C.
4. Preparation examples
4.1, preparation example 1
Taking 50 parts of poria cocos, 20 parts of Chinese yam, 20 parts of wolfberry fruit, 25 parts of rhizoma polygonati, 25 parts of polygonatum odoratum and 5 parts of ginseng, adding 15 times of water, extracting for 1 time, wherein the extraction time is 2.0 hours, concentrating an extracting solution at 65 +/-5 ℃ under reduced pressure until the specific gravity is 1.05 (measured at 60 ℃), adding 18% maltodextrin, fully and uniformly stirring, and performing spray drying, wherein the air inlet temperature is 170 ℃, and the outlet temperature is 90-95 ℃, so as to obtain dry paste. Crushing the dry paste, and sieving the crushed dry paste with a 80-mesh sieve to obtain dry paste powder. Uniformly mixing the dry paste powder, maltodextrin, stevioside and vitamin C according to the proportion of 1:1:0.015:0.40, granulating by a dry granulating machine, sieving the prepared granules by using a swing sieve, and selecting the granules which can pass through a first sieve and the granules which can not pass through a fourth sieve to obtain qualified product granules.
4.2, preparation example 2
Taking 30 parts of poria cocos, 40 parts of Chinese yam, 30 parts of wolfberry fruit, 20 parts of rhizoma polygonati, 15 parts of polygonatum odoratum and 10 parts of ginseng, adding 20 times of water, extracting for 3 times, 0.5 hour each time, combining extracting solutions, concentrating at 65 +/-5 ℃ under reduced pressure until the specific gravity is 1.05 (measured thermally at 60 ℃), adding 13% maltodextrin, fully and uniformly stirring, and performing spray drying at the inlet air temperature of 170 ℃ and the outlet temperature of 90-95 ℃ to obtain dry paste. Crushing the dry paste, and sieving the crushed dry paste with a 80-mesh sieve to obtain dry paste powder. Uniformly mixing the dry extract powder, maltodextrin, stevioside and vitamin C according to the proportion of 1:1.5:0.025:0.50, granulating by a dry granulating machine, sieving the prepared granules by using a swing sieve, and selecting the granules which can pass through a first sieve and the granules which can not pass through a fourth sieve to obtain qualified product granules.
4.3 preparation example 3
Taking 40 parts of poria cocos, 35 parts of Chinese yam, 25 parts of wolfberry fruit, 15 parts of rhizoma polygonati, 15 parts of polygonatum odoratum and 15 parts of ginseng, adding 10 times of water, extracting for 2 times, 1.0 hour each time, combining extracting solutions, concentrating at 65 +/-5 ℃ under reduced pressure until the specific gravity is 1.05 (measured at 60 ℃), adding 15% of maltodextrin, fully and uniformly stirring, and performing spray drying at the inlet air temperature of 170 ℃ and the outlet temperature of 90-95 ℃ to obtain dry paste. Crushing the dry paste, and sieving the crushed dry paste with a 80-mesh sieve to obtain dry paste powder. Uniformly mixing the dry extract powder, maltodextrin, stevioside and vitamin C according to the proportion of 1:1:0.02:0.45, granulating by a dry granulating machine, sieving the prepared granules by using a swing sieve, and selecting the granules which can pass through a first sieve and the granules which can not pass through a fourth sieve to obtain qualified product granules.
5. Fatigue resistance function test
5.1 Experimental animals
The clean male ICR mice, which weigh 18-22 g, are provided by Shanghai Si Laike laboratory animals, Limited liability company, and have the production license number: SCXK (Shanghai) 2007 & 0005. Environmental facility qualification number of SPF experimental animals: SYXK (Su) 2007-0020. All animals were given sterilized rat feed and sterilized water for free access.
5.2 animal grouping and sample administration
The number of animals in each group was 40 in the fatigue resistance test, with 1 negative control group. Preparation example 3 prepared samples 3g, 6g and 18g are respectively taken, purified water is added to 200mL to prepare experimental groups 1, 2 and 3, the animals of the corresponding dose groups are subjected to intragastric administration, the intragastric administration volume is 20mL/kg b.wt., and the negative control group is subjected to intragastric administration for 1 time every day for 30 days continuously.
5.3 Experimental methods
5.3.1 animal growth and organ/body weight ratio determination
At the end of the experiment, mice were sacrificed after weighing, thymus and spleen were removed, weighed on an electronic analytical balance, and the visceral/somatic ratio was calculated.
5.3.2 weight bearing swimming test
After 30min of the last oral gavage of the test object, the mice with 5% weight lead skin loaded on the tail roots are placed in a swimming box, the water depth is more than 30cm, the water temperature is 25 +/-1.0 ℃, and the time from swimming to death of the mice is recorded as the time of the mice bearing the weight for swimming.
5.3.3 determination of serum Urea Nitrogen (BUN) content
After the test substance is administered through oral gavage for 30min at the last time, the mice swim in water with the temperature of 30 ℃ for 90min, and blood is collected after the mice have a rest for 60min, and the separated serum is detected according to the requirements of related kits.
5.3.4 determination of hepatic glycogen content
The animals were sacrificed 30min after the last administration of the test substance, 100mg of liver was accurately weighed, homogenized according to the procedure, centrifuged, glycogen was precipitated with 95% ethanol, and liver glycogen content was determined by anthrone method.
5.3.5 determination of lactic acid content
After 30min of the last administration of the test substance, the blood lactate base value in the resting state is first determined by angular blood collection in the eye: swimming in water at 30 ℃ for 10min, taking out, wiping, immediately taking blood from the inner canthus of the eye for the second time, taking blood from the inner canthus of the eye for the third time after 20min of rest, and measuring the content of lactic acid by using a glucose-lactic acid analyzer.
5.4, Experimental results
5.4.1 Effect of samples on thymus/body weight ratio and spleen/body weight ratio
The effect of the samples on thymus/body weight ratio and spleen/body weight ratio is shown in Table 5-1. From the results, it can be seen that: the thymus ratio and the spleen/body weight ratio of the mice in each experimental group have no significant difference (P is more than 0.05) compared with the control group, which indicates that the sample has no obvious influence on the thymus ratio and the spleen/body weight ratio of the mice.
TABLE 5-1 Effect on organ/body weight ratio in mice: (
n＝10)
5.4.2 sample Effect on mouse body weight
The effect of the samples on weight gain in mice is shown in Table 5-2. From the results, it can be seen that: the mice in the experimental group had no statistically significant difference in weight gain (P > 0.05) compared to the control group, indicating that the sample had no significant effect on the weight gain of the mice.
TABLE 5-2 Effect on weight gain in mice: (
n＝10)
5.4.3 Effect of samples on mouse swimming time under weight, serum Urea Nitrogen level and liver glycogen storage
TABLE 5-3 Effect on mouse weight swimming time, serum Urea Nitrogen level and liver glycogen storage: (
n＝10)
Note: a represents P < 0.05 compared to control; b represents P < 0.01 as compared to the control group.
As can be seen from tables 5-3: the swimming time of the mice of each experimental group is increased, and the liver glycogen content of the mice has no significance (P is more than 0.05) compared with the liver glycogen content of a control group, which indicates that the sample can increase the glycogen reserve of the livers of the mice; after the mice in the experimental group 1 move, the serum urea nitrogen value is lower than that of the control group, the significant difference (P is less than 0.05) is analyzed through the formula difference, the experimental groups 2 and 3 have the significant difference (P is less than 0.01) compared with the control group, the sample can reduce the serum urea nitrogen generation of the fatigue mice, and the urea nitrogen experimental result is positive.
5.4.4 Effect of samples on blood lactate after mouse exercise
As can be seen from tables 5-4: the area under the blood lactic acid curve of each experimental group at three time points after the movement of the mouse is lower than that of the control group, wherein the experimental groups 1 and 2 have significant difference (P is less than 0.05) compared with the control group, the experimental group 3 has very significant difference (P is less than 0.01) compared with the control group, and the sample can reduce the area under the blood lactic acid curve of the mouse after the movement, which indicates that the experimental result is positive.
TABLE 5-4 Effect on blood lactate after exercise in mice
n＝10)
Note: area under the blood lactic acid curve is 5 × (blood lactic acid value before swimming +3 × blood lactic acid value 0min after swimming +2 × blood lactic acid value 20min after resting after swimming); a represents P < 0.05 compared with the control group, and b represents P < 0.01 compared with the control group.
5.5, conclusion
The weight-bearing swimming time of the mice of each experimental group is longer than that of the control group, the blood lactic acid content and the serum urea level of each experimental group are lower than those of the control group, and the blood lactic acid content and the serum urea level of the experimental group 3 are reduced most obviously, so that the sample has the function of relieving physical fatigue.
The above description is only an example of the present invention and common general knowledge in the art is not described here in more detail. It should be noted that, for those skilled in the art, without departing from the present invention, several changes and modifications can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.
The foregoing detailed description of the embodiments of the present application has been presented to illustrate the principles and implementations of the present application, and the description of the embodiments is only intended to facilitate the understanding of the methods and their core concepts of the present application. Meanwhile, a person skilled in the art should, according to the idea of the present application, change or modify the embodiments and applications of the present application based on the scope of the present application. In view of the above, the description should not be taken as limiting the application.
Claims (10)
1. The traditional Chinese medicine composition for relieving fatigue is characterized by being prepared from the following raw materials in parts by weight: 30-50 parts of poria cocos, 20-40 parts of Chinese yam, 10-30 parts of wolfberry fruit, 10-30 parts of rhizoma polygonati, 10-30 parts of polygonatum odoratum and 5-20 parts of ginseng.
2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 35-45 parts of poria cocos, 30-40 parts of Chinese yam, 20-30 parts of wolfberry fruit, 10-20 parts of rhizoma polygonati, 10-20 parts of polygonatum odoratum and 10-15 parts of ginseng.
3. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 40 parts of poria cocos, 35 parts of Chinese yam, 25 parts of wolfberry fruits, 15 parts of rhizoma polygonati, 15 parts of polygonatum odoratum and 15 parts of ginseng.
4. Use of the traditional Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a traditional Chinese medicine preparation, a health product or a food for relieving fatigue.
5. A herbal preparation, health product or food comprising the herbal composition of any one of claims 1 to 3.
6. The Chinese medicinal preparation, health-care product or food as claimed in claim 5, wherein the Chinese medicinal preparation, health-care product or food is a solid beverage.
7. A method for preparing the herbal preparation, nutraceutical, or food product of claim 5 or 6, comprising the steps of:
(1) extraction: weighing appropriate amount of poria cocos, Chinese yam, wolfberry fruits, sealwort, polygonatum odoratum and ginseng, mixing according to a proportion, adding 10-20 times of water or 50-95% of alcohol for extraction for 0.5-2 h, wherein the extraction times are 1-3 times, filtering, combining extracting solutions, and concentrating under reduced pressure to obtain a concentrated solution;
(2) and (3) drying: adding a first auxiliary material into the concentrated solution, fully and uniformly stirring, drying and collecting dry powder;
(3) granulating; adding a second auxiliary material and a flavoring agent into the dry powder, uniformly mixing, granulating and sieving;
(4) packaging: and packaging the sieved granules to obtain the traditional Chinese medicine preparation, the health-care product or the food.
8. The method according to claim 7, wherein the first auxiliary material and the second auxiliary material are the same or different; preferably, the first and second excipients are each selected from one or more of lactose, sugar powder, xylitol, dextrin, maltodextrin and sorbitol; more preferably, the first adjunct is maltodextrin; more preferably, the second adjunct is maltodextrin; particularly preferably, the adding amount of the first auxiliary material accounts for 13-18% of the weight of the concentrated solution.
9. The production method according to claim 7 or 8, wherein the flavoring agent is selected from one or more of a sweetener, an acidulant and a flavoring agent; preferably, the sweetener is selected from one or more of white granulated sugar, xylitol, sorbitol, erythritol, sucralose and stevioside; preferably, the acidulant is selected from one or more of citric acid, malic acid and vitamin C; more preferably, the dry powder: the weight ratio of the second auxiliary materials is 1 (0.5-2); more preferably, the dry powder: the weight ratio of the sweetening agent is 1 (0.01-0.04); more preferably, the dry powder: the weight ratio of the sour agent is 1 (0.035-0.055); particularly preferably, the method of granulation is dry granulation.
10. The method according to claim 7 or 8, wherein the drying is performed by spray drying or freeze drying; preferably, the drying is by spray drying.
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| CN115024490A (en) * | 2022-05-07 | 2022-09-09 | 宁夏医科大学 | Composition with effect of relieving physical fatigue and preparation method and application thereof |
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