CN112639470A - 淀粉样物质相关疾病的诊断方法 - Google Patents

淀粉样物质相关疾病的诊断方法 Download PDF

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Publication number
CN112639470A
CN112639470A CN201980035259.0A CN201980035259A CN112639470A CN 112639470 A CN112639470 A CN 112639470A CN 201980035259 A CN201980035259 A CN 201980035259A CN 112639470 A CN112639470 A CN 112639470A
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amyloid
sample
aggregates
individual
concentration
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Chinese (zh)
Inventor
V·弗克杰维奇
A·格拉斯伦德
J·扎威特
A·缇曼
R·里格勒尔
L·特雷纽斯
S·沃姆兰德
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Amilodia Sweden Ag
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Amilodia Sweden Ag
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Publication of CN112639470A publication Critical patent/CN112639470A/zh
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N2021/6417Spectrofluorimetric devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980035259.0A 2018-04-03 2019-04-01 淀粉样物质相关疾病的诊断方法 Pending CN112639470A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1805466.8 2018-04-03
GBGB1805466.8A GB201805466D0 (en) 2018-04-03 2018-04-03 Methods
PCT/EP2019/058206 WO2019192969A1 (en) 2018-04-03 2019-04-01 Method for the diagnosis of amyloid-associated diseases

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CN112639470A true CN112639470A (zh) 2021-04-09

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CN201980035259.0A Pending CN112639470A (zh) 2018-04-03 2019-04-01 淀粉样物质相关疾病的诊断方法

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US (1) US20220026446A1 (ja)
EP (1) EP3775884B1 (ja)
JP (1) JP7389049B2 (ja)
CN (1) CN112639470A (ja)
GB (1) GB201805466D0 (ja)
WO (1) WO2019192969A1 (ja)

Families Citing this family (2)

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Publication number Priority date Publication date Assignee Title
PL241595B1 (pl) * 2020-02-12 2022-10-31 Univ Warszawski Sposób, zestaw oraz zastosowanie tioflawiny T do wykrywania monomerów i agregatów białka, tioflawina T do zastosowania w diagnozowaniu choroby związanej z agregacją białek oraz sposób generacji wzmocnionej emisji spontanicznej tioflawiny T
CN113008850B (zh) * 2021-02-07 2022-02-25 首都医科大学宣武医院 诊断阿尔茨海默病的用途及诊断阿尔茨海默病的装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008030973A2 (en) * 2006-09-06 2008-03-13 The Board Of Regents Of The University Of Texas System Methods and compositions for the detection of protein folding disorders
CN102429906A (zh) * 2010-09-29 2012-05-02 国家纳米科学中心 氮杂环化合物在制备抑制淀粉样多肽毒性的药物中的用途
US20160077110A1 (en) * 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of Misfolded Amyloid Beta Protein

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4223681B2 (ja) * 1997-09-19 2009-02-12 エボテック・アーゲー 病原性タンパク質沈着の基礎構造の会合の測定方法
JP2009168500A (ja) * 2007-12-17 2009-07-30 Olympus Corp 分子の凝集検出方法及び凝集阻害剤のスクリーニング方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008030973A2 (en) * 2006-09-06 2008-03-13 The Board Of Regents Of The University Of Texas System Methods and compositions for the detection of protein folding disorders
CN102429906A (zh) * 2010-09-29 2012-05-02 国家纳米科学中心 氮杂环化合物在制备抑制淀粉样多肽毒性的药物中的用途
US20160077110A1 (en) * 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of Misfolded Amyloid Beta Protein

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANN TIIMAN ET.AL.: "《Heterogeneity and Turnover of Intermediates during Amyloid-β (Aβ) Peptide Aggregation Studied by Fluorescence Correlation Spectroscopy》", 《BIOCHEMISTRY》, vol. 54, no. 49, 16 November 2015 (2015-11-16), pages 7203 - 7211 *

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EP3775884C0 (en) 2024-05-08
WO2019192969A1 (en) 2019-10-10
JP2021519930A (ja) 2021-08-12
US20220026446A1 (en) 2022-01-27
GB201805466D0 (en) 2018-05-16
EP3775884B1 (en) 2024-05-08
EP3775884A1 (en) 2021-02-17
JP7389049B2 (ja) 2023-11-29

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