CN112618120A - Completely degradable magnesium alloy cardiovascular stent - Google Patents
Completely degradable magnesium alloy cardiovascular stent Download PDFInfo
- Publication number
- CN112618120A CN112618120A CN202011641925.6A CN202011641925A CN112618120A CN 112618120 A CN112618120 A CN 112618120A CN 202011641925 A CN202011641925 A CN 202011641925A CN 112618120 A CN112618120 A CN 112618120A
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- stent
- magnesium alloy
- support
- degradable magnesium
- main body
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- 229910000861 Mg alloy Inorganic materials 0.000 title claims abstract description 35
- 230000002526 effect on cardiovascular system Effects 0.000 title claims abstract description 32
- 208000007536 Thrombosis Diseases 0.000 claims abstract description 30
- 238000006731 degradation reaction Methods 0.000 claims abstract description 30
- 230000015556 catabolic process Effects 0.000 claims abstract description 29
- 239000003814 drug Substances 0.000 claims abstract description 26
- 229940079593 drug Drugs 0.000 claims abstract description 11
- 239000000956 alloy Substances 0.000 claims description 3
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 claims description 2
- 102000002322 Egg Proteins Human genes 0.000 claims description 2
- 108010000912 Egg Proteins Proteins 0.000 claims description 2
- 235000014103 egg white Nutrition 0.000 claims description 2
- 210000000969 egg white Anatomy 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 5
- 238000000034 method Methods 0.000 description 6
- 210000004204 blood vessel Anatomy 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 230000009471 action Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 2
- 238000003491 array Methods 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 230000000593 degrading effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- WAIPAZQMEIHHTJ-UHFFFAOYSA-N [Cr].[Co] Chemical class [Cr].[Co] WAIPAZQMEIHHTJ-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229910001000 nickel titanium Inorganic materials 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011946 reduction process Methods 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22001—Angioplasty, e.g. PCTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0076—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
Abstract
The invention discloses a completely degradable magnesium alloy cardiovascular stent, which comprises a stent main body, wherein a drug layer is fixedly connected to the inner wall of the stent main body, a thrombus removing device is arranged inside the stent main body, an abutting device is fixedly connected to the outer surface of the stent main body, the thrombus removing device is composed of a rotating blade, a rotating shaft and a crushing block, and the abutting device is composed of an abutting spring and an abutting block. This complete degradable magnesium alloy cardiovascular support, setting through thrombus clearing device, having possessed and prevented that the thrombus from piling up the effect that influences the support degradation on support surface, reached and to have carried out complete degradation to the support, setting through butt device, support main part can take place to remove when having reached and preventing to degrade, the purpose that has improved the holding power, the setting on a plurality of through-holes and inside albumen layer is seted up through support main part's surface, area of contact has been increased, the purpose that has improved degradation efficiency has been reached.
Description
Technical Field
The invention relates to the technical field of intravascular stents, in particular to a completely degradable magnesium alloy cardiovascular stent.
Background
The heart stent is a medical instrument commonly used in heart interventional operations, has the function of dredging arterial blood vessels, and is mainly made of stainless steel, nickel-titanium alloy or cobalt-chromium alloy. The device appears in the 80 th 20 th century at the earliest, and is developed through metal brackets, film-coated brackets and soluble brackets, magnesium is a major element necessary for human bodies, has the characteristics of density, elastic modulus, high specific strength, good biocompatibility, degradability and the like which are similar to those of human bones, and has wide application prospect in biomedical fields such as orthopedic implants, cardiovascular brackets, bone tissue engineering brackets and the like.
The existing magnesium alloy cardiovascular stent can be degraded, but the following conditions easily occur during degradation, namely, the magnesium alloy stent can be gradually reduced in the degradation time, the fixing capacity on the surface of a blood vessel is weakened in the reduction process, the movement is easy to occur, adverse effects are caused, the degradation rate is slow, long-time degradation is needed, and thrombus is easily accumulated on the surface of the stent during degradation, the degradation rate and the degradation completion rate are further influenced, so that complete degradation is easy to fail or the degradation time is prolonged.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides a completely degradable magnesium alloy cardiovascular stent which has the advantages of strong fixing capacity, high degradation rate, thrombus accumulation prevention and the like, and solves the problems in the background art.
(II) technical scheme
In order to achieve the purposes of strong fixing capacity, high degradation rate and thrombus accumulation prevention, the invention provides the following technical scheme: the utility model provides a complete degradable magnesium alloy cardiovascular support, includes the support main part, the support main part comprises a plurality of small-size U-shaped framves, and is adjacent U type frame support fixedly connected with connecting rod, the inner wall fixedly connected with medicine layer of support main part, the inside of support main part is provided with thrombus clearing device, the fixed surface of support main part is connected with the butt device, thrombus clearing device comprises rotating vane, pivot and crushing piece, the butt device comprises butt spring and butt piece, the through-hole has been seted up to the surface of support main part.
Preferably, the medicine layer is arranged on the outer side of the thrombus removal device, a plurality of medicines are arranged in the medicine layer, and the abutting block is inserted in the medicine layer.
Preferably, the medicament layer is arranged inside the small U-shaped frame, and the length of the medicament layer is slightly smaller than that of the bracket main body.
Preferably, the through holes are uniformly distributed on the outer surfaces of the small U-shaped frame and the connecting rod, an egg white layer is arranged inside the through holes, and the diameter of each through hole is half of the width of the connecting rod.
Preferably, the butt spring is fixedly connected with one end of the outer surface of the support main body, the other end of the butt spring is fixedly connected with the butt block, and the butt block is in the shape of an arc sheet.
Preferably, the abutting devices are arranged on the outer surface of the bracket main body in multiple layers, five abutting devices are arranged on each layer, and the five abutting devices are distributed on the outer surface of the bracket main body in a circumferential array.
Preferably, the inside of support main part is provided with cylindrical recess, one side of recess is provided with the window, the centre of a circle department of diapire rotates with the pivot in the recess to be connected, the upper end fixedly connected with fixing base of pivot, the surface and the rotating blade fixed connection of fixing base.
Preferably, rotating vane is the circumference array distribution at the surface of fixing base, rotating vane's one end surpasss the recess, the outer wall and the crushing piece fixed connection of pivot bottom, the quantity of crushing piece is provided with a plurality ofly, and is evenly distributed at the surface of pivot.
Preferably, the stent main body, the thrombus removing device and the abutting device are all made of degradable magnesium alloy materials, the degradation rate of the thrombus removing device is slightly higher than that of the stent main body, and the degradation rate of the abutting device is lower than that of the stent main body.
(III) advantageous effects
Compared with the prior art, the invention provides a completely degradable magnesium alloy cardiovascular stent, which has the following beneficial effects:
1. this complete degradable magnesium alloy cardiovascular support, through thrombus clearing device's setting, when using, the swing of moving drive rotating vane through the flow of blood makes rotating vane drive the pivot and rotates, and the pivot drives the crushing piece of bottom and rotates, makes to smash and smashes thrombus near it soon, makes this complete degradable magnesium alloy cardiovascular support possess and has prevented that the thrombus from piling up the effect that influences the support degradation on support surface, has reached and can degrade completely to the support.
2. This complete degradable magnesium alloy cardiovascular support through the setting of butt device, through butt piece butt on vascular inner wall when using, prevents that the support main part from droing, and the support main part can the attenuation when degrading, leads to being difficult to move easily, supports and extrudees the support main part through the butt spring, and the support main part can take place to remove when having reached to prevent to degrade, has improved the purpose of fixity.
3. This complete degradable magnesium alloy cardiovascular support sets up the setting on a plurality of through-holes and inside albumen layer through the surface of support main part, because the albumen layer decomposes earlier when using, then degrades the support again, through the through-hole, has increased area of contact, has reached the purpose that improves degradation efficiency.
Drawings
FIG. 1 is a schematic structural diagram of a completely degradable magnesium alloy cardiovascular stent according to the present invention in front view;
FIG. 2 is an enlarged schematic view of part A of FIG. 1 of a completely degradable magnesium alloy cardiovascular stent according to the present invention;
FIG. 3 is a schematic cross-sectional enlarged view of part B in FIG. 1 of a completely degradable magnesium alloy cardiovascular stent according to the present invention;
fig. 4 is a schematic three-dimensional structure diagram of a completely degradable magnesium alloy cardiovascular stent thrombus removal device provided by the invention.
In the figure: 1. a stent body; 101. a small U-shaped frame; 102. a connecting rod; 2. a drug layer; 4. a rotor blade; 5. a rotating shaft; 6. crushing the blocks; 7. an abutment spring; 8. a butting block; 9. a through hole; 10. a protein layer; 11. a groove; 12. a fixed seat.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-4, a completely degradable magnesium alloy cardiovascular stent comprises a stent main body 1, the stent main body 1 is composed of a plurality of small U-shaped frames 101, the adjacent small U-shaped frames 101 are fixedly connected with connecting rods 102, the inner wall of the stent main body 1 is fixedly connected with a drug layer 2, the drug layer 2 is arranged at the outer side of a thrombus removing device, the drug layer 2 is internally provided with a plurality of drugs, abutting blocks 8 are inserted into the drug layer 2, the drug layer 2 is arranged inside the small U-shaped frames 101, the length of the drug layer 2 is slightly smaller than that of the stent main body 1, the stent main body 1 is internally provided with the thrombus removing device, the outer surface of the stent main body 1 is fixedly connected with the abutting devices, through holes 9 are uniformly distributed on the outer surfaces of the small U-shaped frames 101 and the connecting rods 102, the through holes 9 are internally provided with a protein layer 10, the diameter of the through, the support comprises a support main body 1, a butt spring 7, a rotary shaft 5, a crushing block 6, a rotary blade 7, a butt spring 8, a through hole 9, a plurality of layers of butt devices, five butt devices, a cylindrical groove 11, a window, a fixing seat 12, a rotating blade 4, a rotating block 8, a through hole 9, a plurality of layers of through holes, a plurality of layers of grooves, a plurality of circumferential arrays of the butt devices, the circumferential arrays of the through holes, the rotating blade 4, the, one end of rotating vane 4 surpasses recess 11, the outer wall and the crushing 6 fixed connection of piece of 5 bottoms in pivot, the quantity of crushing 6 is provided with a plurality ofly, and be evenly distributed at the surface of pivot 5, and support main part 1, thrombus clearing device and butt device all adopt degradable magnesium alloy material, and the degradation rate of thrombus clearing device is a little higher than the degradation rate of support main part 1, and the degradation rate of butt device is less than the degradation rate of support main part 1.
When in use, the stent main body 1 is firstly transported to a designated position through the air bag, the air bag is ventilated to the inside, the stent main body 1 is supported, the stent main body 1 is enabled to push the abutting spring 7, the abutting spring 7 is enabled to push the abutting block 8 to abut against the inner wall of the blood vessel, the abutting block 8 can be extruded on the inner wall of the blood vessel through the elasticity of the abutting spring 7 to finish fixation, the stent main body 1 is prevented from moving, the medicine layer 2 is firstly decomposed, the decomposed medicine treats a patient, when the medicine layer 2 is decomposed, the protein layer 10 in the through hole 9 is also decomposed, the through hole 9 is exposed after the decomposition, when the stent main body 1 is degraded, the rotating blade 4 is driven to rotate through the flow of blood, the rotating blade 4 drives the rotating shaft 5, the rotating shaft 5 drives the crushing block 6 to crush thrombus to be coagulated on the inner wall of the stent, in the degradation process, because the degradation rate at different positions is inequality, make thrombus clearing device accomplish the degradation at first, secondly for support subject 1, support subject 1 can make support subject 1 attenuation produce not hard up when degrading, carries out the butt through butt spring 7 to support subject 1's surface this moment, prevents that support subject 1 from droing, improves the fixity ability, support subject 1 degrades the completion back, the butt device also accomplishes the degradation in the time of short afterwards thereupon.
In conclusion, the completely degradable magnesium alloy cardiovascular stent is characterized in that the thrombus clearing device is arranged, when in use, the rotating blade 4 is driven to swing through the flow of blood, the rotating blade 4 drives the rotating shaft 5 to rotate, the rotating shaft 5 drives the crushing block 6 at the bottom to rotate, and the crushing block 6 crushes the thrombus nearby, so that the completely degradable magnesium alloy cardiovascular stent has the effect of preventing thrombus from accumulating on the surface of the stent and influencing the degradation of the stent, and the completely degradable magnesium alloy cardiovascular stent can be completely degraded, the abutting block 8 abuts against the inner wall of a blood vessel when in use through the abutting device to prevent the stent main body 1 from falling off, the stent main body 1 can become thin and is easy to loosen when being degraded, the stent main body 1 is supported and extruded through the abutting spring 7, and the aim of preventing the stent main body 1 from moving when being degraded is achieved, the purpose of fixing ability is improved, and the completely degradable magnesium alloy cardiovascular stent is characterized in that the outer surface of the stent main body 1 is provided with a plurality of through holes 9 and an internal protein layer 10, so that the protein layer 10 is firstly decomposed when in use, and then the stent is degraded, and the contact area is increased through the through holes 9, so that the purpose of improving the degradation efficiency is achieved.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, the use of the verb "comprise a" to define an element does not exclude the presence of another, same element in a process, method, article, or apparatus that comprises the element.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (9)
1. The completely degradable magnesium alloy cardiovascular stent comprises a stent main body and is characterized in that: the support main part comprises a plurality of small-size U-shaped framves, and is adjacent small-size U-shaped frame fixedly connected with connecting rod, the inner wall fixedly connected with medicine layer of support main part, the inside of support main part is provided with thrombus clearing device, the external fixed surface of support main part is connected with the butt device, thrombus clearing device comprises rotating vane, pivot and crushing piece, the butt device comprises butt spring and butt piece, the through-hole has been seted up to the surface of support main part.
2. The completely degradable magnesium alloy cardiovascular stent of claim 1, wherein: the medicine layer is arranged on the outer side of the thrombus removing device, a plurality of medicines are arranged in the medicine layer, and the abutting block is inserted in the medicine layer.
3. The completely degradable magnesium alloy cardiovascular stent of claim 1, wherein: the medicine layer is arranged inside the small U-shaped frame, and the length of the medicine layer is slightly smaller than that of the bracket main body.
4. The completely degradable magnesium alloy cardiovascular stent of claim 1, wherein: the through-hole is evenly distributed on the outer surfaces of the small U-shaped frame and the connecting rod, an egg white layer is arranged inside the through-hole, and the diameter of the through-hole is half of the width of the connecting rod.
5. The completely degradable magnesium alloy cardiovascular stent of claim 1, wherein: the support is characterized in that the butt spring is fixedly connected with the outer surface of the support main body at one end, the other end of the butt spring is fixedly connected with the butt block, and the butt block is arc-shaped.
6. The completely degradable magnesium alloy cardiovascular stent of claim 5, wherein: the support comprises a support body and is characterized in that multiple layers of abutting devices are arranged on the outer surface of the support body, five abutting devices are arranged on each layer, and the five abutting devices are distributed on the outer surface of the support body in a circumferential array mode.
7. The completely degradable magnesium alloy cardiovascular stent of claim 1, wherein: the inside of support main part is provided with cylindrical recess, one side of recess is provided with the window, the centre of a circle department of diapire rotates with the pivot in the recess to be connected, the upper end fixedly connected with fixing base of pivot, the surface and the rotating vane fixed connection of fixing base.
8. The completely degradable magnesium alloy cardiovascular stent of claim 7, wherein: the rotating blade is distributed for circumference array at the surface of fixing base, rotating blade's one end surpasss the recess, the outer wall and the crushing piece fixed connection of pivot bottom, the quantity of crushing piece is provided with a plurality ofly, and is evenly distributed at the surface of pivot.
9. The completely degradable magnesium alloy cardiovascular stent of claim 1, wherein: the stent main body, the thrombus removing device and the abutting device are all made of degradable magnesium alloy materials, the degradation rate of the thrombus removing device is slightly higher than that of the stent main body, and the degradation rate of the abutting device is lower than that of the stent main body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011641925.6A CN112618120A (en) | 2020-12-31 | 2020-12-31 | Completely degradable magnesium alloy cardiovascular stent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011641925.6A CN112618120A (en) | 2020-12-31 | 2020-12-31 | Completely degradable magnesium alloy cardiovascular stent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112618120A true CN112618120A (en) | 2021-04-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011641925.6A Pending CN112618120A (en) | 2020-12-31 | 2020-12-31 | Completely degradable magnesium alloy cardiovascular stent |
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| Country | Link |
|---|---|
| CN (1) | CN112618120A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW592677B (en) * | 2003-05-28 | 2004-06-21 | Univ Nat Taipei Technology | A process of manufacturing stent with therapeutic function in the human body |
| CN107280728A (en) * | 2017-08-04 | 2017-10-24 | 李莉 | A kind of thrombus remover for preventing blood vessel from damaging |
| CN108578023A (en) * | 2018-04-25 | 2018-09-28 | 广西中医药大学 | A kind of graphene oxide cardiovascular stents and preparation method thereof |
| CN108771573A (en) * | 2018-06-26 | 2018-11-09 | 柏为（武汉）医疗科技股份有限公司 | It is a kind of can degradable absorption bracket for eluting medicament and its application |
| CN111658249A (en) * | 2020-07-14 | 2020-09-15 | 李晨雪 | Opening support device for avoiding error caused by uneven support of opening wall |
-
2020
- 2020-12-31 CN CN202011641925.6A patent/CN112618120A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW592677B (en) * | 2003-05-28 | 2004-06-21 | Univ Nat Taipei Technology | A process of manufacturing stent with therapeutic function in the human body |
| CN107280728A (en) * | 2017-08-04 | 2017-10-24 | 李莉 | A kind of thrombus remover for preventing blood vessel from damaging |
| CN108578023A (en) * | 2018-04-25 | 2018-09-28 | 广西中医药大学 | A kind of graphene oxide cardiovascular stents and preparation method thereof |
| CN108771573A (en) * | 2018-06-26 | 2018-11-09 | 柏为（武汉）医疗科技股份有限公司 | It is a kind of can degradable absorption bracket for eluting medicament and its application |
| CN111658249A (en) * | 2020-07-14 | 2020-09-15 | 李晨雪 | Opening support device for avoiding error caused by uneven support of opening wall |
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Application publication date: 20210409 |