CN108771573A - It is a kind of can degradable absorption bracket for eluting medicament and its application - Google Patents
It is a kind of can degradable absorption bracket for eluting medicament and its application Download PDFInfo
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- CN108771573A CN108771573A CN201810669126.6A CN201810669126A CN108771573A CN 108771573 A CN108771573 A CN 108771573A CN 201810669126 A CN201810669126 A CN 201810669126A CN 108771573 A CN108771573 A CN 108771573A
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- stent
- eluting medicament
- inner stent
- degradable
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Surgery (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses it is a kind of can degradable absorption bracket for eluting medicament, which includes inner stent, outer stent and foldable shaft；The inner stent is connected with outer stent by foldable shaft；The inner stent surface coats anti-proliferative drug coating, and the outer stent surface coats anti-inflammation drugs coating；The mesh of inner stent and the mesh of outer stent are in be staggered.The support force of the holder increases, and can effectively prevent the restenosis of tube chamber；Drug on outer stent can play the role of anti-inflammatory, and with the degradation of outer stent, drug slow release, after waiting outer stents degradable, outer layer drug release is complete；After outer stent is degradable, internal stent automatic expansion and contacted with tube chamber, the drug in internal stent starts to be sustained, and prevents lumen organization's hyperplasia；Inner stent is contacted with outer stent with tube chamber different tissues, ensures the uniformity of drug release.
Description
Technical field
The present invention relates to the field of medical instrument technology, more particularly to it is a kind of can degradable absorption medicament elution branch
Frame.
Background technology
Eustachian tube connects tympanum and pharynx nasalis, and ostium tympanicum is opened on tubal wall, and pharynx mouth is opened on nasopharynx side wall, is
The unique path that middle ear are communicated with the external world, and an important factor for maintenance middle ear normal ventilation and auditory ossicular chain acoustic.Eustachian tube
Obstruction or blocking lead to negative middle ear pressure, and with the retraction (sucking) of ear-drum.In adult, this some usually adjoint ear is not
It is suitable, it swells or feeling of stress, and slight hearing impairment and head noise (tinnitus) can be caused.It may be asymptomatic in children.Such as
Fruit obstruction extends, then fluid can be extracted out from the mucous membrane of middle ear, generate the lesion of otitis media serosa.This and the infection of the upper respiratory tract
It is incorporated in the reason of children's intermediate frequency occurs and is hearing impairment relevant with the disease.
The incidence of Eustachian tube disfunction (Eustachian Tube Dysfunction, ETD) in adult exists
1%-5%, children ETD and tympanitis incidence are relative to adult's higher, and there are about 40% at least to live through 1 time by 10 years old or less children
Of short duration ETD.There are many reason of causing ETD, but all closely related with the unique anatomical structure of Eustachian tube.Cartilaginous part of auditory tube
Mucous membrane is inflamed, congested, loose or even ossified by excessive block of secretion, prevents Eustachian tube from actively opening, causes
Hydrotympanum causes the symptoms such as ear muffle, tinnitus, Hearing.ETD exacerbations may occur in which secretory otitis media, suppurative middle ear
The severe complications such as inflammation, cholesteatoma.
ETD treatments can be divided into drug therapy and operative treatment, and common drug has nose spray hormone, decongestant, antihistamine
Deng, but it is long, complicated for operation there are treatment time, function improves limited defect.Operative treatment ETD is frequently with pharyngotympanic tube catheterization
Method, floating catheter dilatation, eardrum cut tube placing operation etc., but operability, safety and efficacy etc. have much room for improvement, and are possible to
Tympanosclerosis, eardrum is caused permanently to be perforated, the complication such as otitis media suppurative or even cholesteatoma.Sacculus bougienage of eustachian tube
The advantages such as (Balloon Eustachian Tuboplasty, BET) is minimally invasive with its, easy to operate, therapeutic effect is good are clinically
It is applied, but its restenosis rate is higher.
Currently, holder grows up on the basis of balloon dilatation, effect is reliable, method is easy, it is traumatic it is small,
Interventional therapeutic technique easy for patients to accept.
Chinese Patent Application No. 201210507878.5 discloses a kind of degradable infant's magnesium alloy esophageal stent, institute
The Esophageal Stent stated includes：Cyclic monomer, by magnesium alloy wire with W-fold, connection forms cylindrical shape and has elastic force,
There is bending part at the both ends of cyclic monomer；Tie point, making the cyclic monomer, axial series connect each other；Protrusion, bottom
Portion is located at tie point, and top is located at the outside of Esophageal Stent, and oesophagus can be embedded in after magnesium alloy esophageal stent expansion release
Wall plays fixing bracket.
Chinese Patent Application No. 200710012808.1, disclose it is a kind of can degradable absorption medicine slow-release magnesium alloy
Holder and application are made up of magnesium alloy precision tube of laser cutting, and it is magnesium that rack surface, which has bi-layer coating structure, internal layer,
The temporary protective layer of alloy substrate, outer layer are the Degradable high polymer film for being mixed with drug.
Although magnesium alloy bracket plays certain effect in the narrow treatment of cavity, holder is led to by magnesium-alloy tube
It crosses and is laser-cut into netted holder, during cavity supports, there are discontinuity, support force are weaker, and drug
It is sustained the not strong defect of uneven, narrow positions specific aim.
Invention content
The invention solves first technical problem be to provide it is a kind of can degradable absorption bracket for eluting medicament；It should
Holder expands eustachian tube lumen after interventional procedure, restores the normal function of eustachian tube lumen, the last degradable absorption of holder；
Also, the holder can be to greatest extent so that drug uniform slow release on eustachian tube lumen inner wall.
The invention solves second technical problem be to provide it is a kind of it is above-mentioned can degradable absorption medicament elution branch
The application of frame.
In order to solve the first technical problem mentioned above, invention adopts the following technical scheme that：
The present invention it is a kind of can degradable absorption bracket for eluting medicament, which includes inner stent, outer
Layer holder and foldable shaft；The inner stent is connected with outer stent by foldable shaft；The inner stent surface
Anti-proliferative drug coating is coated, the outer stent surface coats anti-inflammation drugs coating；The mesh and outer stent of inner stent
Mesh in being staggered.
Further, the thickness 0.05-0.5mm, a diameter of 1.0-28mm, length 5-400mm of the inner stent.
Further, the thickness 0.02-0.3mm, a diameter of 2.0-30mm, length 5-400mm of the outer stent.
Further, the thickness of the inner stent is more than the thickness of outer stent；The diameter of the inner stent is less than
The diameter of outer stent；The inner stent is identical with the length of outer stent.
Further, the angle of foldable shaft is 10 ° -80 ° or 100 ° -170 °.
Further, the material of the inner stent is magnesium alloy, ferroalloy, kirsite or polylactic acid；The outer layer branch
The material of frame is magnesium alloy, kirsite, polylactic acid or ferroalloy；The material of the foldable shaft is magnesium alloy, ferroalloy, zinc
Alloy, polylactic acid, collagen or chitosan.
Further, the anti-proliferative drug coating include taxol, sirolimus, everolimus, Suo Taluomosi, bar
It is one or more in Li Mosi, Na Fumosi, Ma Limosi, mitomycin and Batroxobin；The anti-inflammation drugs coating packet
Include numb furan drop nose, Fexofenadine spit of fland, epinastine hydrochloride, dexamethasone, betamethasone, antibiotic, ephedrine, Naphazoline,
It is one or more in oxymetazoline hydrochloride.
Further, the anti-proliferative drug coating and anti-inflammation drugs coating using in dipping, spraying, coating one kind or
It is prepared by a variety of methods.
Further, using laser integral cutting, laser between the inner stent and outer stent and foldable shaft
Welding, sweat soldering are fixedly connected with the one or more of glue sticking.
The present invention can degradable absorption bracket for eluting medicament in coronary arteries blood vessel, peripheral blood vessel, oesophagus, tracheae, defeated
Application in urinary catheter, bile duct, enteron aisle and Eustachian tube lesion.
Any range recorded in the present invention includes any numerical value between end value and end value and end value or end value
Between the arbitrary subrange that is constituted of any number.
Unless otherwise specified, each raw material in the present invention can be obtained by commercially available purchase, equipment used in the present invention
The conventional equipment in fields can be used or carried out with reference to the prior art of fields.
Compared with prior art, the present invention has the advantages that：
1) support force of holder increases, and can effectively prevent the restenosis of tube chamber；
2) drug on outer stent can play the role of anti-inflammatory, and with the degradation of outer stent, and drug is slowly released
It puts, after waiting outer stents degradable, outer layer drug release is complete；
3) after outer stent is degradable, internal stent automatic expansion and contacted with tube chamber, the drug in internal stent is opened
Begin sustained release, prevents lumen organization's hyperplasia；
4) inner stent is contacted with outer stent with tube chamber different tissues, ensures the uniformity of drug release.
Description of the drawings
Specific embodiments of the present invention will be described in further detail below in conjunction with the accompanying drawings
Fig. 1 is the structural schematic diagram of the bracket for eluting medicament of the present invention；
Fig. 2 is the side schematic view of the bracket for eluting medicament of Fig. 1.
Specific implementation mode
In order to illustrate more clearly of the present invention, with reference to preferred embodiment, the present invention is described further.Ability
Field technique personnel should be appreciated that following specifically described content is illustrative and be not restrictive, this should not be limited with this
The protection domain of invention.
It should be noted that when element is referred to as " being fixed on " or " being set to " another element, it can be directly another
On one element or it is connected on another element.When an element is known as " being connected to " another element, it can
To be directly to another element or be indirectly connected on another element.
It is to be appreciated that term " length ", " width ", "upper", "lower", "front", "rear", "left", "right", "vertical",
The orientation or positional relationship of the instructions such as "horizontal", "top", "bottom" "inner", "outside" is that orientation based on ... shown in the drawings or position are closed
System, is merely for convenience of description of the present invention and simplification of the description, not indicating or implying the indicated device or element must have
Specific orientation, with specific azimuth configuration and operation, therefore be not considered as limiting the invention.
In addition, term " first ", " second " are used for description purposes only, it is not understood to indicate or imply relative importance
Or implicitly indicate the quantity of indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or
Implicitly include one or more this feature.In the description of the present invention, the meaning of " plurality " is two or more,
Unless otherwise specifically defined.
Shown in Fig. 1, Fig. 2, the present invention it is a kind of can degradable absorption bracket for eluting medicament, the bracket for eluting medicament
Including inner stent 10, outer stent 20 and foldable shaft 30；The inner stent 10 and outer stent 20 are by foldable
Shaft 30 connects；10 surface of the inner stent coats anti-proliferative drug coating (not shown), the outer stent surface
Coat anti-inflammation drugs coating (not shown)；The mesh of the mesh of inner stent 10 and outer stent 20 is in be staggered.
The inner stent 10 and outer stent 20 are connected by foldable shaft 30, and the support force of integral support can be made to increase
Add, the restenosis of tube chamber can be effectively prevent；Drug on outer stent 20 can play the role of anti-inflammatory, and with outer stent
Degradation, drug slow release, after waiting outer stents 20 degradable, outer layer drug release is complete；Outer stent 20 drops completely
Xie Hou, internal stent automatic expansion and contacted with tube chamber, the drug in internal stent starts to be sustained, and prevents lumen organization's hyperplasia,
Inner stent 10 is finally also degraded.The holder successively degraded can ensure the restenosis of eustachian tube lumen to greatest extent.
The mesh of the mesh of the inner stent 10 and outer stent 20 is in be staggered, in use, Eustachian tube
Parietal cell touches outer stent 20 first, and the fraction medicine touched can have an effect, and tubal wall part groups of cells
It knits and protruding portion is formed by 20 mesh of outer stent, these protruding portions can touch inner stent 10 so that the effect of drug is more
It is accurate and uniform to add.
In certain embodiments of the present invention, the thickness 0.05-0.5mm, a diameter of 1.0- of the inner stent 10
28mm, length 5-400mm.
In certain embodiments of the present invention, the thickness 0.02-0.3mm, a diameter of 2.0- of the outer stent 20
30mm, length 5-400mm.
In certain embodiments of the present invention, the thickness of the inner stent 10 is more than the thickness of outer stent 20；It is described
The diameter of inner stent 10 is less than the diameter of outer stent 20；The inner stent 10 is identical with the length of outer stent 20.Institute
The thickness for stating inner stent 10 may insure that outer stent 20 is first degraded completely more than the thickness of outer stent 20, and be unlikely to
Existing inner stent 10 is first degraded complete hollow out phenomenon.
In certain embodiments of the present invention, the angle of foldable shaft is 10 ° -80 ° or 100 ° -170 °.
In certain embodiments of the present invention, the material of the inner stent 10 is magnesium alloy, ferroalloy or polylactic acid；Institute
The material for stating outer stent is magnesium alloy, polylactic acid or ferroalloy；The material of the foldable shaft be magnesium alloy, ferroalloy,
Polylactic acid, collagen or chitosan.
In certain embodiments of the present invention, the anti-proliferative drug coating includes taxol, sirolimus, Yi Weimo
Department, Suo Taluomosi, Bali are not taken charge of, are in Na Fumosi and Ma Limosi one or more；The anti-inflammation drugs coating packet
Include numb furan drop nose, Fexofenadine spit of fland, epinastine hydrochloride, dexamethasone, betamethasone, antibiotic, ephedrine, Naphazoline,
It is one or more in oxymetazoline hydrochloride.
In certain embodiments of the present invention, the anti-proliferative drug coating and anti-inflammation drugs coating using dipping, spraying,
It is prepared by one or more methods in coating.
In certain embodiments of the present invention, it is adopted between the inner stent 10 and outer stent 20 and foldable shaft 30
One or more with laser welding, sweat soldering and glue sticking are fixedly connected.
Embodiment 1
It is a kind of can degradable absorption bracket for eluting medicament, which includes inner stent 10, outer layer branch
Frame 20 and foldable shaft 30；The inner stent 10 and outer stent 20 are connected by foldable shaft 30；The internal layer branch
10 surface of frame coats anti-proliferative drug coating (not shown), and the outer stent surface coats anti-inflammation drugs coating (in figure
It is not shown)；The mesh of the mesh of inner stent 10 and outer stent 20 is in be staggered.
The thickness 0.05mm, a diameter of 1.0mm, length 5mm of the inner stent 10；
The thickness 0.02mm, a diameter of 2.0mm, length 5mm of the outer stent 20；
The angle of the foldable shaft 30 is 10 °；
The material of the inner stent 10 is degradable magnesium alloy；The material of the outer stent is degradable magnesium alloy；
The material of the foldable shaft is degradable magnesium alloy；
The anti-proliferative drug coating includes taxol and sirolimus；The anti-inflammation drugs coating includes numb furan drop
Nose and Fexofenadine spit of fland；
The anti-proliferative drug coating and anti-inflammation drugs coating are prepared using dipping method；
It is fixed using laser welding between the inner stent 10 and outer stent 20 and foldable shaft 30.
Embodiment 2
It is a kind of can degradable absorption bracket for eluting medicament, which includes inner stent 10, outer layer branch
Frame 20 and foldable shaft 30；The inner stent 10 and outer stent 20 are connected by foldable shaft 30；The internal layer branch
10 surface of frame coats anti-proliferative drug coating (not shown), and the outer stent surface coats anti-inflammation drugs coating (in figure
It is not shown)；The mesh of the mesh of inner stent 10 and outer stent 20 is in be staggered；
The thickness 0.5mm, a diameter of 4.0mm, length 400mm of the inner stent 10；
The thickness 0.3mm, a diameter of 5.0mm, length 400mm of the outer stent 20；
The angle of the foldable shaft 30 is 80 °；
The material of the inner stent 10 is polylactic acid；The material of the outer stent is polylactic acid；The foldable axis
The material of bar is polylactic acid；
The anti-proliferative drug coating is not taken charge of comprising Bali；The anti-inflammation drugs coating includes epinastine hydrochloride；
The anti-proliferative drug coating and anti-inflammation drugs coating are prepared using spraying method；
It is fixed using glue sticking between the inner stent 10 and outer stent 20 and foldable shaft 30.
Embodiment 3
The present invention it is a kind of can degradable absorption bracket for eluting medicament, the bracket for eluting medicament include inner stent 10,
Outer stent 20 and foldable shaft 30；The inner stent 10 and outer stent 20 are connected by foldable shaft 30；It is described
10 surface of inner stent coats anti-proliferative drug coating (not shown), and the outer stent surface coats anti-inflammation drugs coating
(not shown)；The mesh of the mesh of inner stent 10 and outer stent 20 is in be staggered.
The thickness 0.2mm, a diameter of 2.5mm, length 50mm of the inner stent 10；
The thickness 0.1mm, a diameter of 3.5mm, length 50mm of the outer stent 20；
The angle of the foldable shaft is 50 °；
The material of the inner stent 10 is degradable ferroalloy；The material of the outer stent is degradable ferroalloy；
The material of the foldable shaft is degradable ferroalloy；
The anti-proliferative drug coating includes Na Fumosi and Ma Limosi；The anti-inflammation drugs coating includes hydrochloric acid hydroxyl first
Oxazoline；
The anti-proliferative drug coating and anti-inflammation drugs coating are prepared using painting method；
It is fixed using laser welding between the inner stent 10 and outer stent 20 and foldable shaft 30.
Embodiment 4
Can degradable absorption application of the bracket for eluting medicament in Eustachian tube lesion：
By embodiment 2 obtain can degradable absorption bracket for eluting medicament by operation be placed in Eustachian tube, pass through
Observation is crossed, outer stent was degraded completely at 60 days or so；Inner stent was degraded completely at 90 days or so.
Obviously, the above embodiment of the present invention be only to clearly illustrate example of the present invention, and not be pair
The restriction of embodiments of the present invention.For those of ordinary skill in the art, may be used also on the basis of the above description
To make other variations or changes in different ways.Here all embodiments can not be exhaustive.It is every to belong to this hair
Row of the obvious changes or variations that bright technical solution is extended out still in protection scope of the present invention.
Claims (10)
1. it is a kind of can degradable absorption bracket for eluting medicament, it is characterised in that：The bracket for eluting medicament include inner stent,
Outer stent and foldable shaft；The inner stent is connected with outer stent by foldable shaft；The inner stent table
Face coats anti-proliferative drug coating, and the outer stent surface coats anti-inflammation drugs coating；The mesh of inner stent and outer layer branch
The mesh of frame is in be staggered.
2. according to claim 1 can degradable absorption bracket for eluting medicament, it is characterised in that：The inner stent
Thickness 0.05-0.5mm, a diameter of 1.0-28mm, length 5-400mm.
3. according to claim 1 can degradable absorption bracket for eluting medicament, it is characterised in that：The outer stent
Thickness 0.02-0.3mm, a diameter of 2.0-30mm, length 5-400mm.
4. according to claim 1 can degradable absorption bracket for eluting medicament, it is characterised in that：The inner stent
Thickness is more than the thickness of outer stent；The diameter of the inner stent is less than the diameter of outer stent；The inner stent and outer
The length of layer holder is identical.
5. according to claim 1 can degradable absorption bracket for eluting medicament, it is characterised in that：The foldable shaft
Angle be 10 ° -80 ° or 100 ° -170 °.
6. according to claim 1 can degradable absorption bracket for eluting medicament, it is characterised in that：The inner stent
Material is magnesium alloy, ferroalloy, kirsite or polylactic acid；The material of the outer stent be magnesium alloy, kirsite, polylactic acid or
Ferroalloy；The material of the foldable shaft is magnesium alloy, kirsite, ferroalloy, polylactic acid, collagen or chitosan.
7. according to claim 1 can degradable absorption bracket for eluting medicament, it is characterised in that：The anti-proliferative drug
Coating include taxol, sirolimus, everolimus, Suo Taluomosi, Bali do not take charge of, Na Fumosi, Ma Limosi, mitogen it is mould
It is one or more in element and Batroxobin；The anti-inflammation drugs coating include numb furan drop nose, Fexofenadine spit of fland, hydrochloric acid according to
It is one or more in sting, dexamethasone, betamethasone, antibiotic, ephedrine, Naphazoline, oxymetazoline hydrochloride.
8. according to claim 1 can degradable absorption bracket for eluting medicament, it is characterised in that：The anti-proliferative drug
Coating and anti-inflammation drugs coating are prepared using one or more methods in dipping, spraying, coating.
9. according to claim 1 can degradable absorption bracket for eluting medicament, it is characterised in that：The inner stent and
Using laser integral cutting, laser welding, one kind or more of sweat soldering and glue sticking between outer stent and foldable shaft
Kind is fixedly connected.
10. as described in claim 1 can degradable absorption bracket for eluting medicament coronary arteries blood vessel, peripheral blood vessel, oesophagus,
Application in tracheae, ureter, bile duct, enteron aisle and Eustachian tube lesion.
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| CN201810669126.6A CN108771573B (en) | 2018-06-26 | 2018-06-26 | Completely degradable and absorbable drug eluting stent and application thereof |
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| CN201810669126.6A CN108771573B (en) | 2018-06-26 | 2018-06-26 | Completely degradable and absorbable drug eluting stent and application thereof |
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| CN108771573B CN108771573B (en) | 2020-10-13 |
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| CN112618120A (en) * | 2020-12-31 | 2021-04-09 | 郑州美港高科生物科技有限公司 | Completely degradable magnesium alloy cardiovascular stent |
| CN113101024A (en) * | 2021-04-08 | 2021-07-13 | 哈尔滨医科大学 | Pulmonary artery drug eluting stent and stent kit |
| CN113198089A (en) * | 2021-04-20 | 2021-08-03 | 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） | Central venous pipeline for preventing embolism and infection |
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